CN113040949A - Orthodontic bracket adhesive mixed with zinc oxide quantum dots - Google Patents
Orthodontic bracket adhesive mixed with zinc oxide quantum dots Download PDFInfo
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- CN113040949A CN113040949A CN202110260120.5A CN202110260120A CN113040949A CN 113040949 A CN113040949 A CN 113040949A CN 202110260120 A CN202110260120 A CN 202110260120A CN 113040949 A CN113040949 A CN 113040949A
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- adhesive
- zinc oxide
- quantum dots
- oxide quantum
- orthodontic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C7/00—Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
- A61C7/12—Brackets; Arch wires; Combinations thereof; Accessories therefor
- A61C7/14—Brackets; Fixing brackets to teeth
- A61C7/16—Brackets; Fixing brackets to teeth specially adapted to be cemented to teeth
Abstract
The invention discloses an orthodontic bracket adhesive mixed with zinc oxide quantum dots, which relates to the technical field of medicines and is characterized in that the zinc oxide quantum dots are used as fluorescent components and antibacterial components and are added into the bracket adhesive used in orthodontic treatment. The fluorescence property can instruct an orthodontist to remove redundant adhesive in the bracket bonding process and instruct the orthodontist to remove the residual adhesive on the tooth surface when the bracket is dismantled; the antibacterial property of the product can kill cariogenic bacteria streptococcus mutans.
Description
Technical Field
The invention relates to the technical field of medicine technology, in particular to an orthodontic bracket adhesive mixed with zinc oxide quantum dots.
Background
Orthodontics is a subject for treating malocclusion, and the treatment method comprises a fixed correction technology and a bracket-free correction technology, wherein the fixed correction technology is developed, has better retention and higher treatment efficiency, and is the most common correction technology at present. The principle of the fixing and correcting technology is that a bracket is fixed to the surface of enamel by using an adhesive, and the force generated by deformation of an arch wire or the force from other sources is transmitted to teeth through the bracket, so that the teeth move to treat the malocclusion deformity. However, the presence of brackets and adhesives results in difficult tooth surface cleaning, plaque biofilm is prone to accumulate and produce acid which can lead to enamel demineralization, manifested as chalky spots and even caries, thereby affecting the aesthetics and health of the patient's teeth.
To address this problem, two strategies are currently used clinically to prevent or treat: (1) inhibiting the aggregation of plaque biofilm, reducing its acid production to reduce the appearance of enamel demineralization using an antibacterial formulation; (2) remineralizing preparations such as fluoride and CPP-ACP are used to remineralize demineralized enamel in time, thereby reducing the extent of enamel demineralization. The various reagents are mainly used for preventing and treating enamel demineralization in the forms of mouthwash, protective paint, toothpaste and the like, and the action modes depend on the subjective matching degree of patients or increase the chair-side operation time of treatment, so that good effects are difficult to obtain. In addition, multiple evidence-based medical studies find that remineralizing preparations such as fluoride, CPP-ACP and the like have limited enamel demineralization prevention effect and cannot prevent the occurrence of enamel demineralization. Therefore, the clinical problem of enamel demineralization still deserves attention and research of researchers.
Disclosure of Invention
Based on the defects of the prior art, the technical problem to be solved by the invention is to provide the orthodontic bracket adhesive mixed with the zinc oxide quantum dots, which has good enamel demineralization reducing effect, and the zinc oxide quantum dots are applied to the orthodontic bracket adhesive, so that the fluorescent property and the antibacterial property of the orthodontic adhesive are endowed. The research of the scheme of the invention is subsidized by national science fund (NO: 81901044).
In order to solve the technical problem, the invention provides an orthodontic bracket adhesive mixed with zinc oxide quantum dots, which comprises a bracket adhesive and the zinc oxide quantum dots.
Preferably, the orthodontic bracket adhesive mixed with the zinc oxide quantum dots further comprises part or all of the following technical characteristics:
as an improvement of the technical scheme, the zinc oxide quantum dots can emit yellow fluorescence under the excitation of ultraviolet rays, and can kill cariogenic bacteria streptococcus mutans.
As an improvement of the technical scheme, the mass of the zinc oxide quantum dots is 10-30% of that of the bracket adhesive.
As an improvement of the technical scheme, the zinc oxide quantum dots are zinc oxide particles with the particle size of less than 10 nm.
In an improvement of the above technical solution, the bracket adhesive is any one of a resin-based orthodontic adhesive, a glass ion-based orthodontic adhesive, a photo-curing glass ion-based orthodontic adhesive, or a resin-modified glass ion-based orthodontic adhesive.
The preparation method of the orthodontic bracket adhesive mixed with the zinc oxide quantum dots comprises the step of mixing the zinc oxide quantum dots serving as additives into the bracket adhesive.
The application of the orthodontic bracket adhesive mixed with the zinc oxide quantum dots is characterized in that the orthodontic bracket adhesive mixed with the zinc oxide quantum dots is used for bonding orthodontic brackets.
The zinc oxide quantum dots used in the invention have fluorescence property, can emit yellow fluorescence (about 550nm in wavelength) under the excitation of ultraviolet rays (about 350nm in wavelength), and also have bactericidal effect and can kill cariogenic bacteria streptococcus mutans. Therefore, the orthodontic bracket adhesive with antibacterial property and fluorescence property, which is synthesized by mixing the zinc oxide quantum dots into the orthodontic adhesive, is beneficial to an orthodontist to distinguish the adhesive and accurately remove the redundant adhesive, and can kill cariogenic bacteria streptococcus mutans in the orthodontic treatment process, thereby reducing the occurrence of enamel demineralization. The main advantages are represented by the following two points:
1: fluorescence is given to the adhesive, the position of the residual adhesive is indicated when the bracket is adhered and when the bracket is removed, and the orthodontic physician is guided to remove the residual adhesive.
When bonding brackets, excess adhesive may spill around the bracket base and, due to the color close to that of the tooth, may be difficult to remove completely. These residual adhesives can become sites for bacteria to easily accumulate during the subsequent orthodontic treatment, thereby causing demineralization of the enamel surrounding the brackets. The orthodontic bracket adhesive mixed with the zinc oxide quantum dots can emit yellow fluorescence (the wavelength is about 550 nm) under the irradiation of ultraviolet rays (the wavelength is about 350 nm). After the adhesive is applied, the bracket can be irradiated by ultraviolet rays after the bracket is bonded, and redundant adhesive around the bracket bottom plate can be quickly and thoroughly removed under the indication of yellow fluorescence, so that the accumulation of bacteria in the orthodontic treatment process is reduced.
When the bracket is removed, part of the adhesive is debonded from the bracket bottom plate and remains on the tooth surface. The adhesive is thin and has a color close to that of the teeth, and whether the adhesive is completely ground or not is difficult to judge in the process of grinding by using a slow mobile phone. If the abrasion is excessive, normal tooth tissues are easily damaged, while if the abrasion is insufficient, part of the adhesive is still remained on the tooth surface, and bacteria are easily gathered on the adhesive to cause enamel demineralization after the orthodontic treatment is finished. After the adhesive is applied, the tooth surface can be irradiated by ultraviolet rays after the bracket is removed, and the adhesive remained on the tooth surface can be rapidly and thoroughly removed under the indication of yellow fluorescence without damaging tooth tissues.
2: endows the adhesive with fluorescence performance, and kills cariogenic bacteria streptococcus mutans in the orthodontic treatment process, thereby reducing the appearance of enamel demineralization.
In the process of orthodontic treatment, bacteria are easy to accumulate in brackets bonded on the surfaces of teeth, cariogenic bacteria mainly comprising streptococcus mutans are accumulated around the brackets, and organic acid is secreted to cause enamel demineralization. The orthodontic adhesive mixed with the zinc oxide quantum dots has antibacterial performance and can kill the streptococcus mutans, so that the activity of the streptococcus mutans around the bracket is inhibited in the orthodontic treatment process, and enamel demineralization caused by adhesion and aggregation of cariogenic bacteria is avoided.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly understood, the present invention may be implemented in accordance with the contents of the description, and in order to make the above and other objects, features, and advantages of the present invention more clearly understood, the following detailed description is given in conjunction with the preferred embodiments.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings of the embodiments will be briefly described below.
FIG. 1: the zinc oxide quantum dot fluorescence photograph related to embodiment 1 of the invention;
FIG. 2: a photograph of an adhesive containing zinc oxide quantum dots according to example 1 of the present invention;
FIG. 3: the photo of the bracket is removed after the adhesive related to the embodiment 1 of the invention is applied to the bracket;
FIG. 4: the adhesive mixed with the zinc oxide quantum dots in embodiment 1 of the invention has a bactericidal effect;
FIG. 5: the adhesive mixed with zinc oxide quantum dots according to example 1 of the present invention has biocompatibility.
Detailed Description
Other aspects, features and advantages of the present invention will become apparent from the following detailed description, which, when taken in conjunction with the drawings, illustrate by way of example the principles of the invention.
Example 1: an orthodontic bracket adhesive mixed with zinc oxide quantum dots is characterized in that the zinc oxide quantum dots are mixed into a resin orthodontic adhesive to be synthesized;
the resin adhesive is Transbond XT adhesive resin, and the mixing amount of the zinc oxide quantum dots is 20 percent of the mass of the adhesive resin;
taking a picture of zinc oxide quantum dot powder under ultraviolet irradiation, taking a picture of bonding resin mixed with zinc oxide quantum dots under ultraviolet irradiation, bonding a bracket to a tooth surface by using the bonding resin mixed with the zinc oxide quantum dots, and taking a picture of residual bonding resin on the tooth surface under ultraviolet irradiation after removing the bracket; evaluating the anti-streptococcus-deformation performance of the bonding resin by using an MTT method; the biocompatibility of the adhesive resin to gingival fibroblasts was evaluated by the CCK-8 method.
1. Photograph of zinc oxide quantum dot powder under ultraviolet irradiation (shown in FIG. 1)
The zinc oxide quantum dot powder emits yellow fluorescence under the irradiation of an ultraviolet light source (about 350 nm).
2. Photograph of adhesive resin mixed with zinc oxide quantum dots under ultraviolet irradiation (shown in FIG. 2)
After zinc oxide quantum dots were mixed in an adhesive resin at a ratio of 20%, the adhesive resin was cured using a photo-curing lamp, and the adhesive resin appeared white under a natural light source and emitted yellow fluorescence under irradiation of an ultraviolet light (about 350 nm) light source.
3. Photograph of the tooth surface after the bracket was removed, showing the adhesive resin under ultraviolet irradiation (shown in FIG. 3)
After the bracket is adhered by using the adhesive mixed with zinc oxide quantum dots, the bracket is detached, the residual adhesive on the surface of the tooth is observed under a natural light source and an ultraviolet (mixed with a small amount of purple visible light) light source respectively, under the natural light source, the color of the adhesive on the surface of the tooth is close to that of the tooth, and the adhesive is difficult to distinguish (figure 3A), and under the irradiation of ultraviolet, the adhesive on the surface of the tooth emits yellow fluorescence, and can be easily distinguished from the tooth tissue (figure 3B).
4. Streptococcus mutans resistance of adhesive resin mixed with zinc oxide quantum dots (see FIG. 4)
An adhesive resin (20% group) containing 20% of zinc oxide quantum dots and an adhesive resin (NC group) containing no zinc oxide quantum dots were prepared into a resin sheet having a diameter of 4mm and a thickness of 1mm, and then photo-cured. After ultraviolet sterilization, the resin sheet was immersed in a BHIS culture solution containing Streptococcus mutans and anaerobically cultured at 37 ℃. After 24 hours of culture, the culture solution was aspirated, the activity of Streptococcus mutans on the resin sheet surface was detected using MTT kit, and the activity of NC group was used as a control to calculate the relative survival of 20% of Streptococcus mutans on the resin sheet surface. The result shows that the bonding resin mixed with 20 percent of zinc oxide quantum dots has better anti-streptococcus mutans capability.
5. Biocompatibility of adhesive resin incorporating Zinc oxide Quantum dots (shown in FIG. 5)
An adhesive resin (20% group) containing 20% of zinc oxide quantum dots and an adhesive resin (NC group) containing no zinc oxide quantum dots were prepared into a resin sheet having a diameter of 4mm and a thickness of 1mm, and then photo-cured. And after ultraviolet sterilization, soaking the resin sheet in a culture medium of gingival fibroblast to prepare a leaching solution. Culturing gingival fibroblast in leaching solution at 37 deg.C under 5% CO2. After 24 hours of culture, the leaching solution was aspirated, and the proliferation potency of gingival fibroblasts was measured by using a CCK-8 kit to evaluate the biocompatibility of the resin sheet. The results show that 20% zinc oxide quantum dots are mixedThe biocompatibility of the bonding resin is not different from that of the bonding resin without the zinc oxide quantum dots, namely, the biocompatibility of the bonding resin is not influenced by the zinc oxide quantum dots.
Example 2: an orthodontic bracket adhesive mixed with zinc oxide quantum dots is characterized in that the zinc oxide quantum dots are mixed into a glass ion type orthodontic adhesive to be synthesized;
the glass ionic adhesive is GC Fuji II glass ionic cement, and zinc oxide quantum dots are mixed into powder of the glass ionic cement in a mass fraction of 20%;
example 3: an orthodontic bracket adhesive mixed with zinc oxide quantum dots is characterized in that the zinc oxide quantum dots are mixed into a photocuring glass ion type orthodontic adhesive to be synthesized;
the light-cured glass ionic adhesive is Fuji II LC light-cured glass ionic cement, and zinc oxide quantum dots are mixed into powder of the Fuji II LC light-cured glass ionic cement in a mass fraction of 20%;
example 4: an orthodontic bracket adhesive mixed with zinc oxide quantum dots is characterized in that the zinc oxide quantum dots are mixed into a resin improved glass ion type orthodontic adhesive to be synthesized;
the resin modified glass ionic adhesive is a GC Fuji Ortho LC light-cured resin modified glass ionic orthodontic adhesive, and zinc oxide quantum dots are mixed into powder of the GC Fuji Ortho LC light-cured resin modified glass ionic orthodontic adhesive in a mass fraction of 20%.
The raw materials listed in the invention, the upper and lower limits and interval values of the raw materials of the invention, and the upper and lower limits and interval values of the process parameters (such as temperature, time and the like) can all realize the invention, and the examples are not listed.
While the foregoing is directed to the preferred embodiment of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow.
Claims (7)
1. The orthodontic bracket adhesive mixed with the zinc oxide quantum dots is characterized in that: the adhesive comprises bracket adhesive and zinc oxide quantum dots.
2. The adhesive for orthodontic brackets mixed with zinc oxide quantum dots as claimed in claim 1, wherein: the zinc oxide quantum dots can emit yellow fluorescence under the excitation of ultraviolet rays, and can kill cariogenic bacteria streptococcus mutans.
3. The adhesive for orthodontic brackets mixed with zinc oxide quantum dots as claimed in claim 1, wherein: the mass of the zinc oxide quantum dots is 10-30% of that of the bracket adhesive.
4. The adhesive for orthodontic brackets mixed with zinc oxide quantum dots as claimed in claim 1, wherein: the zinc oxide quantum dots are zinc oxide particles with the particle size of less than 10 nm.
5. The adhesive for orthodontic brackets mixed with zinc oxide quantum dots as claimed in claim 1, wherein: the bracket adhesive is any one of resin orthodontic adhesive, glass ion orthodontic adhesive, light-cured glass ion orthodontic adhesive or resin-modified glass ion orthodontic adhesive.
6. A method for preparing the orthodontic bracket adhesive mixed with the zinc oxide quantum dots as claimed in any one of claims 1 to 5, wherein the method comprises the following steps: zinc oxide quantum dots are mixed into the bracket adhesive as an additive.
7. Use of the zinc oxide quantum dot mixed orthodontic bracket adhesive of any one of claims 1-5, wherein: the orthodontic bracket adhesive mixed with the zinc oxide quantum dots is used for bonding orthodontic brackets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110260120.5A CN113040949A (en) | 2021-03-10 | 2021-03-10 | Orthodontic bracket adhesive mixed with zinc oxide quantum dots |
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| CN202110260120.5A CN113040949A (en) | 2021-03-10 | 2021-03-10 | Orthodontic bracket adhesive mixed with zinc oxide quantum dots |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115120504A (en) * | 2022-07-20 | 2022-09-30 | 武汉大学 | Photochromic orthodontic bracket adhesive and preparation method and application thereof |
| CN115708782A (en) * | 2022-09-29 | 2023-02-24 | 邢台市琅泰本元医疗器械有限公司 | Preparation method of orthodontic bracket adhesive |
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| US4479782A (en) * | 1983-04-18 | 1984-10-30 | Scientific Pharmaceuticals, Inc. | Visible light-cured orthodontic adhesive |
| US5639239A (en) * | 1995-01-12 | 1997-06-17 | Earle; Jeffrey O. | Dental dentin bonding system |
| CN101587071A (en) * | 2009-07-01 | 2009-11-25 | 东南大学 | Fluorescence immunoassay method of using zinc oxide quantum dots to mark antibody |
| CN101674797A (en) * | 2007-05-31 | 2010-03-17 | 学校法人日本大学 | Adhesive for teeth-straightening members |
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| US20180000559A1 (en) * | 2014-12-22 | 2018-01-04 | Richard Titlebaum | System and method for introducing photosensitive dyes via an insert into a root canal in a tooth, method for producing said dye impregnated insert and method of using said dye-impregnated insert |
| US20200009020A1 (en) * | 2016-06-03 | 2020-01-09 | Den-Mat Holdings, Llc | Caries-Resistant Composite Resin |
| CN112390282A (en) * | 2020-11-16 | 2021-02-23 | 郑州大学 | Hydrophilic zinc oxide quantum dot and preparation method and application thereof |
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2021
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Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1049036A (en) * | 1964-07-28 | 1966-11-23 | Biorex Laboratories Ltd | Dental cements |
| US4479782A (en) * | 1983-04-18 | 1984-10-30 | Scientific Pharmaceuticals, Inc. | Visible light-cured orthodontic adhesive |
| US5639239A (en) * | 1995-01-12 | 1997-06-17 | Earle; Jeffrey O. | Dental dentin bonding system |
| CN101674797A (en) * | 2007-05-31 | 2010-03-17 | 学校法人日本大学 | Adhesive for teeth-straightening members |
| CN102223853A (en) * | 2008-10-01 | 2011-10-19 | 3M创新有限公司 | Dental appliance, process for producing a dental appliance and use thereof |
| CN101587071A (en) * | 2009-07-01 | 2009-11-25 | 东南大学 | Fluorescence immunoassay method of using zinc oxide quantum dots to mark antibody |
| US20180000559A1 (en) * | 2014-12-22 | 2018-01-04 | Richard Titlebaum | System and method for introducing photosensitive dyes via an insert into a root canal in a tooth, method for producing said dye impregnated insert and method of using said dye-impregnated insert |
| CN204765982U (en) * | 2015-07-09 | 2015-11-18 | 南方医科大学南方医院 | Just abnormal support groove and just abnormal buccal surface pipe with nano - zinc oxide coating |
| US20200009020A1 (en) * | 2016-06-03 | 2020-01-09 | Den-Mat Holdings, Llc | Caries-Resistant Composite Resin |
| CN106389133A (en) * | 2016-11-03 | 2017-02-15 | 张静 | Preparation method of glass ionomer cement for orthodontic bonding |
| CN112390282A (en) * | 2020-11-16 | 2021-02-23 | 郑州大学 | Hydrophilic zinc oxide quantum dot and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115120504A (en) * | 2022-07-20 | 2022-09-30 | 武汉大学 | Photochromic orthodontic bracket adhesive and preparation method and application thereof |
| CN115708782A (en) * | 2022-09-29 | 2023-02-24 | 邢台市琅泰本元医疗器械有限公司 | Preparation method of orthodontic bracket adhesive |
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Application publication date: 20210629 |
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