CN113020097A - Rotatable magnetic bead cleaning system - Google Patents
Rotatable magnetic bead cleaning system Download PDFInfo
- Publication number
- CN113020097A CN113020097A CN202110127326.0A CN202110127326A CN113020097A CN 113020097 A CN113020097 A CN 113020097A CN 202110127326 A CN202110127326 A CN 202110127326A CN 113020097 A CN113020097 A CN 113020097A
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- China
- Prior art keywords
- mounting plate
- magnetic bead
- cleaning
- magnet
- driving motor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
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- Cleaning By Liquid Or Steam (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a rotatable magnetic bead cleaning system which comprises a first mounting plate, a second mounting plate, a stepping screw rod motor, a driving motor, a belt wheel transmission assembly and a magnetic assembly. The first mounting plate and the second mounting plate are arranged oppositely, and are matched with the linear bearings through two guide shafts to realize relative sliding connection. The stepping screw motor is fixed on the first mounting plate, and the second mounting plate is fixed with a screw nut connected with the stepping screw motor. The magnetic assembly is connected to the second mounting plate and comprises four magnet units horizontally arranged at intervals. The driving motor and the belt wheel transmission assembly are arranged on the second mounting plate and are used for driving the two magnet units at the two ends to rotate. Compared with the prior art, the system is simple in structure, and the cleaning effect of magnetic bead cleaning is effectively improved.
Description
Technical Field
The invention relates to a reaction cup magnetic bead cleaning system for a chemiluminescence analyzer.
Background
When the chemiluminescence system is used for cleaning and separating magnetic beads, a magnetic field formed by a magnet is used for adsorbing the magnetic beads in the reaction cup, other unreacted substances are cleaned and separated, and other substances wrapped on the magnetic beads need to be separated, so that the magnetic beads are completely adsorbed when waste liquid needs to be pumped, and the magnetic beads need to be completely scattered when cleaning liquid is flushed.
Disclosure of Invention
The purpose of the invention is as follows: to the above prior art, a rotatable magnetic bead cleaning system is provided for improving the cleaning effect of the magnetic bead.
The technical scheme is as follows: the rotatable magnetic bead cleaning system comprises a first mounting plate, a second mounting plate, a stepping screw motor, a driving motor, a belt wheel transmission assembly and a magnetic assembly;
the first mounting plate and the second mounting plate are arranged oppositely, and the first mounting plate and the second mounting plate are in relative sliding connection through the matching of two guide shafts and linear bearings; the stepping screw motor is fixed on the first mounting plate, and a screw nut connected with the stepping screw motor is fixed on the second mounting plate;
the magnetic assembly is connected to the second mounting plate and comprises four magnet units which are horizontally arranged at intervals, and each magnet unit is of a circular structure consisting of a semicircular S-pole magnet and a semicircular N-pole magnet;
the driving motor and the belt wheel transmission assembly are arranged on the second mounting plate, and the driving motor is connected with the belt wheel transmission assembly and used for driving the two magnet units at the two ends to rotate.
Further, the belt wheel transmission assembly comprises a driving wheel, two synchronous belt wheels, an idler wheel and a synchronous belt; the two magnet units at the two ends are respectively connected with a pin shaft, the pin shaft penetrates through the second mounting plate and is connected with a bearing fixed on the second mounting plate, and the synchronous belt wheels are respectively and fixedly connected with the tail end of one pin shaft; the synchronous belt is tensioned on the driving wheel and the two synchronous belt wheels through the idle wheel.
Further, still including wasing needle and waste liquid needle, be equipped with the magnetic bead collection device on the pipeline that the waste liquid needle is connected, the magnetic bead collection device is the cell body that the bottom is fixed with the magnet.
Furthermore, the bottom of first mounting panel and second mounting panel is installed fluted type opto-coupler detector and opto-coupler baffle respectively.
The stepping screw rod motor is connected with a stepping screw rod motor through a screw rod, and the stepping screw rod motor is connected with a driving motor through a screw rod; and in the process of cleaning the magnetic beads in the reaction cup, controlling the driving motor to drive the two magnet units at the two ends to rotate periodically in a forward and reverse rotation mode all the time.
Further, the positive and negative rotation amplitude is 90 degrees.
Has the advantages that: compared with the existing reaction cup magnetic bead cleaning mechanism, the rotatable magnetic bead cleaning system disclosed by the invention has the advantage that the cleaning effect of magnetic bead cleaning is effectively improved by always periodically rotating the two magnet units at the two ends in a positive and negative rotation alternating manner.
Drawings
FIG. 1 is a schematic diagram of a front view of the system of the present invention;
FIG. 2 is a schematic diagram of the right view of the system of the present invention;
FIG. 3 is a schematic diagram of a rear view of the system of the present invention;
FIG. 4 is a schematic structural view of a rotating mechanism of the magnet units at both ends;
fig. 5 is a schematic diagram of the working state of the system of the present invention.
Detailed Description
The invention is further explained below with reference to the drawings.
As shown in fig. 1 to 4, a rotatable magnetic bead cleaning system includes a first mounting plate 1, a second mounting plate 2, a stepping screw motor 3, a driving motor 4, a pulley transmission assembly, and a magnetic assembly.
The magnetic assembly is connected to the second mounting plate 2 and includes four magnet units 16 horizontally arranged at intervals, and the magnet units 16 are circular structures formed by semicircular S-pole magnets and semicircular N-pole magnets.
The pulley transmission assembly comprises a drive pulley 17, two timing pulleys 6, an idler pulley 9 and a timing belt 5. The two magnet units 16 at the two ends are respectively connected with a pin shaft 7, the pin shaft 7 passes through the second mounting plate 2 and is connected with a bearing 20 fixed on the second mounting plate 2, and the synchronous belt wheels 6 are respectively and fixedly connected with the tail end of one pin shaft 7. The timing belt 5 is tensioned via an idler pulley 9 over a drive pulley 17 and two timing pulleys 6. The middle two magnet units 16 are fixed directly to the second mounting plate 2. The driving motor 4 is arranged on the second mounting plate 2, and the driving motor 4 is connected with the belt wheel transmission set and used for driving the two magnet units 16 at the two ends to rotate. The controller of the system is connected with a stepping screw rod motor 3 and a driving motor 4, and in the process of cleaning magnetic beads in the reaction cup, the driving motor 4 is controlled to drive two magnet units 16 at two ends to rotate periodically and alternately in forward and reverse directions all the time, and the forward and reverse rotation amplitude is 90 degrees.
As shown in fig. 5, a cleaning station bottom plate 11 is horizontally fixed on the outer side surface of the first mounting plate 1, a reaction cup rail 12 is arranged on the cleaning station bottom plate 11, and four magnet units 16 horizontally arranged at intervals are opposite to the reaction cup rail 12. Cleaning needle 14 and waste liquid needle 15 are located reaction cup track 12 top, are equipped with the magnetic bead collection device on the pipeline that waste liquid needle 15 is connected, and the magnetic bead collection device is the cell body that the bottom is fixed with the magnet for adsorb the intraductal residual magnetic bead of waste liquid of flowing through, can be used for detecting the magnetic bead losing rate in the cleaning process.
When the system cleans the magnetic beads of the reaction cup, when the first reaction cup moves to the position opposite to the first magnet unit 16 on the left side, the first reaction cup stays in the magnet unit 16 for a plurality of seconds, and in the time period, after the operation of continuously extracting the reaction liquid in the reaction cup for two times through the waste liquid needle 15, the cleaning liquid is injected into the reaction cup through the cleaning needle 14; then the first reaction cup is moved to the position opposite to the second magnet unit 6, at the moment, the second reaction cup is just moved to the position opposite to the first magnet unit 16 on the left side, and the cleaning operation of the second reaction cup is started; until the first reaction cup moves to the position opposite to the first four magnet units 16, waste liquid is extracted from the reaction cup through the waste liquid needle 15, and the cleaning operation of the first reaction cup is completed; then the waste liquid extraction operation of the subsequent reaction cups is completed in sequence.
Wherein, the driving motor 4 is controlled to drive the two magnet units 16 at the two ends to rotate periodically in a positive and negative rotation mode all the time. When the waste liquid needle 15 continuously performs two operations of extracting the reaction liquid in the reaction cup, in order to reduce the magnetic loss, the magnetic component needs to be controlled to be close to one side of the reaction cup 13, that is, a stronger magnetic field is provided. When the cleaning liquid is injected, the magnetic assembly is controlled to be away from one side of the reaction cup 13, namely, the magnetic field is weakened, and in the process that the magnetic assembly is away from the reaction cup, the magnetic beads gathered together are driven to centrifugally scatter by the simultaneous rotating motion of the first magnet unit 6, and the magnetic beads are fully scattered under the impact of the cleaning liquid, so that the magnetic beads are fully ensured to be in effective contact with the cleaning liquid. When the position of the fourth magnet unit 16 is opposite, the magnet unit 16 needs to be controlled to be close to one side of the reaction cup 13 again when waste liquid is extracted, so that the magnetic loss is effectively reduced while the waste liquid is completely extracted. The reaction cup passes through the middle two magnet units 16 in sequence, the magnetic assembly is close to and far away from the reaction cup continuously and alternately, namely, the magnetic beads are enabled to carry out effective repeated movement in the cleaning liquid by controlling the strength of the magnetic field, and when the waste liquid is pumped out, the track stroke of the movement of the magnetic beads in the cleaning liquid is further increased by rotating the rotating magnetic field applied by the close fourth magnet unit 16, and the cleaning effect of the magnetic beads is further improved.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (6)
1. The rotatable magnetic bead cleaning system is characterized by comprising a first mounting plate (1), a second mounting plate (2), a stepping screw motor (3), a driving motor (4), a belt wheel transmission assembly and a magnetic assembly;
the first mounting plate (1) and the second mounting plate (2) are arranged oppositely, and the first mounting plate (1) and the second mounting plate (2) are in relative sliding connection through the matching of two guide shafts (8) and a linear bearing (10); the stepping screw motor (3) is fixed on the first mounting plate (1), and a screw nut (9) connected with the stepping screw motor (3) is fixed on the second mounting plate (2);
the magnetic assembly is connected to the second mounting plate (2) and comprises four magnet units (16) which are horizontally arranged at intervals, and each magnet unit (16) is of a circular structure consisting of a semicircular S-pole magnet and a semicircular N-pole magnet;
driving motor (4) and band pulley transmission assembly set up on second mounting panel (2), driving motor (4) are connected band pulley transmission group for it is rotatory to drive two magnet units (16) at both ends.
2. The rotatable bead washing system of claim 1, wherein the pulley drive assembly comprises a drive pulley (17), two synchronous pulleys (6), an idler pulley (9), and a synchronous belt (5); two magnet units (16) at two ends are respectively connected with a pin shaft (7), the pin shaft (7) penetrates through the second mounting plate (2) and is connected with a bearing (20) fixed on the second mounting plate (2), and the synchronous belt wheels (6) are respectively and fixedly connected with the tail end of one pin shaft (7); the synchronous belt (5) is tensioned on the driving wheel (17) and the two synchronous belt wheels (6) through the idle wheel (9).
3. The system for cleaning rotatable magnetic beads according to claim 1, further comprising a cleaning needle (14) and a waste liquid needle (15), wherein a magnetic bead collecting device is arranged on a pipeline connected with the waste liquid needle (15), and the magnetic bead collecting device is a groove body with a magnet fixed at the bottom.
4. A rotatable magnetic bead cleaning system according to claim 1, wherein the bottom of the first mounting plate (1) and the bottom of the second mounting plate (2) are respectively provided with a groove type optical coupling detector (18) and an optical coupling baffle (19).
5. A rotatable magnetic bead washing system according to any one of claims 1-4, further comprising a controller, wherein the controller is connected to the stepping screw motor (3) and the driving motor (4); in the process of cleaning the magnetic beads in the reaction cup, the driving motor (4) is controlled to drive the two magnet units (16) at the two ends to rotate periodically in a forward and reverse rotation mode all the time.
6. The rotatable magnetic bead washing system of claim 5, wherein the positive and negative rotation is of 90 degrees in amplitude.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110127326.0A CN113020097B (en) | 2021-01-29 | 2021-01-29 | Rotatable magnetic bead cleaning system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110127326.0A CN113020097B (en) | 2021-01-29 | 2021-01-29 | Rotatable magnetic bead cleaning system |
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| Publication Number | Publication Date |
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| CN113020097A true CN113020097A (en) | 2021-06-25 |
| CN113020097B CN113020097B (en) | 2023-09-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110127326.0A Active CN113020097B (en) | 2021-01-29 | 2021-01-29 | Rotatable magnetic bead cleaning system |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920675A (en) * | 2014-04-11 | 2014-07-16 | 中国科学院苏州生物医学工程技术研究所 | Magnetic microsphere cleaning device for full-automatic chemiluminescent immunoassay instrument |
| WO2016046402A1 (en) * | 2014-09-25 | 2016-03-31 | Altergon Italia S.R.L. | Apparatus for separation, washing and mixing of magnetic particles in a reaction cup, adapted to be used in an immunoanalyzer system |
| CN110153121A (en) * | 2019-06-21 | 2019-08-23 | 苏州长光华医生物医学工程有限公司 | It is a kind of for cleaning the magnetic particle adsorbent equipment and its cleaning equipment of reaction cup |
| CN110501513A (en) * | 2019-09-19 | 2019-11-26 | 南京迪格诺斯生物技术有限公司 | A kind of chemiluminescent analyzer |
| US20200080998A1 (en) * | 2018-09-11 | 2020-03-12 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Adsorption Mechanism, Cleaning Device, Chemiluminescence Detector and Cleaning Method |
| CN111841877A (en) * | 2019-10-08 | 2020-10-30 | 潍坊市康华生物技术有限公司 | Device for reducing magnetic bead loss in magnetic separation and use method |
| CN112198330A (en) * | 2020-09-27 | 2021-01-08 | 深圳市国赛生物技术有限公司 | Magnetic bead cleaning and separating device |
| WO2021007853A1 (en) * | 2019-07-18 | 2021-01-21 | 烟台艾德康生物科技有限公司 | Fully-automatic magnetic bead cleaning device |
-
2021
- 2021-01-29 CN CN202110127326.0A patent/CN113020097B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920675A (en) * | 2014-04-11 | 2014-07-16 | 中国科学院苏州生物医学工程技术研究所 | Magnetic microsphere cleaning device for full-automatic chemiluminescent immunoassay instrument |
| WO2016046402A1 (en) * | 2014-09-25 | 2016-03-31 | Altergon Italia S.R.L. | Apparatus for separation, washing and mixing of magnetic particles in a reaction cup, adapted to be used in an immunoanalyzer system |
| US20200080998A1 (en) * | 2018-09-11 | 2020-03-12 | Shenzhen New Industries Biomedical Engineering Co., Ltd. | Adsorption Mechanism, Cleaning Device, Chemiluminescence Detector and Cleaning Method |
| CN110153121A (en) * | 2019-06-21 | 2019-08-23 | 苏州长光华医生物医学工程有限公司 | It is a kind of for cleaning the magnetic particle adsorbent equipment and its cleaning equipment of reaction cup |
| WO2021007853A1 (en) * | 2019-07-18 | 2021-01-21 | 烟台艾德康生物科技有限公司 | Fully-automatic magnetic bead cleaning device |
| CN110501513A (en) * | 2019-09-19 | 2019-11-26 | 南京迪格诺斯生物技术有限公司 | A kind of chemiluminescent analyzer |
| CN111841877A (en) * | 2019-10-08 | 2020-10-30 | 潍坊市康华生物技术有限公司 | Device for reducing magnetic bead loss in magnetic separation and use method |
| CN112198330A (en) * | 2020-09-27 | 2021-01-08 | 深圳市国赛生物技术有限公司 | Magnetic bead cleaning and separating device |
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| Publication number | Publication date |
|---|---|
| CN113020097B (en) | 2023-09-08 |
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