CN113018499A - 一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法 - Google Patents

一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法 Download PDF

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CN113018499A
CN113018499A CN202110250789.6A CN202110250789A CN113018499A CN 113018499 A CN113018499 A CN 113018499A CN 202110250789 A CN202110250789 A CN 202110250789A CN 113018499 A CN113018499 A CN 113018499A
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李莉
张育宁
李忠平
秦瑶
郭书萍
崔红宙
帅慧荣
刘宏业
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First Hospital of Shanxi Medical University
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Abstract

本发明具体为一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，解决了现有皮肤创伤采用干性敷料进行治疗存在愈合速度慢且换药时会产生疼痛和二次损伤的问题。一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，采用如下步骤：a、在去离子水中加入聚乙烯醇，得到聚乙烯醇溶液；b、将氧化石墨烯溶液加入聚乙烯醇溶液中制得反应液；c、将反应液反复循环冷冻解冻后得到复合水凝胶；d、将复合水凝胶的背层喷涂硅酸凝胶，里层滴臭氧油，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。本发明形成的复合敷贴同时具有吸湿、杀菌、抗病毒和抗真菌的功效，具有高透气性和防水性。

Description

一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法
技术领域
本发明涉及医药技术领域，具体为一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法。
背景技术
皮肤是人体最大的器官，构成了人体与外界环境相互作用的第一道屏障，一旦出现烧伤、创伤、皮肤疾病等情况时，愈合过程的护理极其重要。
皮肤治疗过程中各种创面的愈合关键在于清洁和抗感染，所以如何能够对创面进行特殊的护理一直是研究的重要课题和领域。由于皮肤自我修复有一定的局限性，并可能伴有各种感染的发生。因而使用伤口敷料成为促进皮肤组织修复或愈合的有效辅助手段。
目前，临床上皮肤创伤治疗最主要的护理方式是通过表面给药(抗生素)和纱布固定的方式。传统干性敷料如纱布等虽然能够维持伤口区域干燥，吸收伤口渗出液，但不能为皮肤组织的修复与重建创造一个湿润的环境，而且使用的抗生素的抗菌作用受局限，对病毒和真菌的作用不明显，很容易造成耐药菌的产生，影响愈合速度，同时换药时会产生疼痛和二次损伤。
发明内容
本发明为了解决现有皮肤创伤采用干性敷料进行治疗存在愈合速度慢且换药时会产生疼痛和二次损伤的问题，提供了一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法。
本发明是采用如下技术方案实现的：一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，采用如下步骤：
a、在每百毫升去离子水中加入8-12g聚乙烯醇，搅拌2-5h后冷却至室温得到聚乙烯醇溶液，去离子水的温度为92-96℃；
b、将质量体积比为4mg/ml的氧化石墨烯溶液加入聚乙烯醇溶液中，室温搅拌12-24h制得反应液，聚乙烯醇溶液与氧化石墨烯溶液的体积比为1:0.5-2；
c、将反应液转移至玻璃容器中密封，并在零下15-20℃中冷冻，然后在室温下解冻，反复循环冷冻解冻后得到复合水凝胶；
d、将复合水凝胶的背层喷涂硅酸凝胶，并在60-70℃脱水老化3-5h；
e、将臭氧油滴在复合水凝胶的里层，复合水凝胶的背层负压处理后密闭静置，臭氧油与聚乙烯醇溶液的体积比为1:3-6，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。
水凝胶是一种亲水性聚合物，能够溶胀且保留大量的水并能维持三维(3D)网络结构，与传统疗法相比，可以加工成各种形状，从而与伤口更有效地接触；用水凝胶敷料敷贴在伤口上时，不但不会粘连伤口、破坏新生组织，而且可为伤口提供一个良好的湿润愈合环境，也可以包埋药物杀死各种细菌，改善创面微环境，避免伤口感染。
氧化石墨烯作为一种新型的典型二维材料，也是一种具有优越生物相容性的生物材料，能够促进人类及哺乳类动物细胞的生长，其优异的生物相容性使得氧化石墨烯材料能够广泛应用于组织工程、组织植入、伤口治疗以及药物释放等，而其易于功能化的特性使得氧化石墨烯基材料能够成为合成各种功能材料的理想的候选材料。在水凝胶的聚合物网络中引入二维氧化石墨烯，可使得整个水凝胶结构更趋于稳定，机械性能更强。
臭氧又称为三原子氧，是一种天然氧化剂，臭氧是目前已知的一种广谱、高效、快速、安全、无二次污染的杀菌气体，可杀灭细菌芽胞、病毒、真菌等各种病原体。臭氧油是利用臭氧固化技术将纯净臭氧气体与食用级植物油—山茶油反应生成的一种纯天然混合物，臭氧油具备广谱杀菌、穿透性强、安全性高、无耐药性等特点，已被临床广泛应用于皮肤、黏膜的抗菌、消炎、止痒、解毒等方面。
反应液在玻璃容器中冷冻时长20h，解冻时长4h，通过冷冻交联方式反复冷冻解冻三次。
复合水凝胶背层负压处理时长为5s，密闭静置时长3h。
本发明具有如下有益效果：
1、首次将臭氧油与水凝胶复合，形成的复合敷贴同时具有吸湿和杀菌、抗病毒双重功能，对皮肤黏膜的刺激性小，使用方便，杀菌效果好，稳定性好，易于储存，无副作用，无残留物，无耐药性；
2、水凝胶选取氧化石墨烯和聚乙烯醇为主要成分，两者穿插交联形成稳定的网络结构，使水凝胶具有更好的韧性和机械强度；
3、将臭氧油通过吸附反应负载在氧化石墨烯和聚乙烯醇构成的水凝胶中，臭氧与氧化石墨烯和聚乙烯醇水凝胶协同作用，水凝胶复合敷贴的抗菌灭毒效果得到进一步的提升；
4、采用单纯的物理方法进行复合，安全性和可实施性得到有效的保证，具有高透气性和防水性。
具体实施方式
实施例1
一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，采用如下步骤：
a、在每百毫升去离子水中加入8聚乙烯醇，搅拌2h后冷却至室温得到聚乙烯醇溶液，去离子水的温度为92℃；
b、将质量体积比为4mg/ml的氧化石墨烯溶液加入聚乙烯醇溶液中，室温搅拌12h制得反应液，聚乙烯醇溶液与氧化石墨烯溶液的体积比为1:0.5；
c、将反应液转移至玻璃容器中密封，并在零下15℃中冷冻，然后在室温下解冻，反复循环冷冻解冻后得到复合水凝胶；
d、将复合水凝胶的背层喷涂硅酸凝胶，并在60℃脱水老化3h；
e、将臭氧油滴在复合水凝胶的里层，复合水凝胶的背层负压处理后密闭静置，臭氧油与聚乙烯醇溶液的体积比为1:3，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。
反应液在玻璃容器中冷冻时长20h，解冻时长4h，通过冷冻交联方式反复冷冻解冻三次。
复合水凝胶背层负压处理时长为5s，密闭静置时长3h。
实施例2
一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，采用如下步骤：
a、在每百毫升去离子水中加入12g聚乙烯醇，搅拌5h后冷却至室温得到聚乙烯醇溶液，去离子水的温度为96℃；
b、将质量体积比为4mg/ml的氧化石墨烯溶液加入聚乙烯醇溶液中，室温搅拌24h制得反应液，聚乙烯醇溶液与氧化石墨烯溶液的体积比为1:2；
c、将反应液转移至玻璃容器中密封，并在零下20℃中冷冻，然后在室温下解冻，反复循环冷冻解冻后得到复合水凝胶；
d、将复合水凝胶的背层喷涂硅酸凝胶，并在70℃脱水老化5h；
e、将臭氧油滴在复合水凝胶的里层，复合水凝胶的背层负压处理后密闭静置，臭氧油与聚乙烯醇溶液的体积比为1:6，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。
反应液在玻璃容器中冷冻时长20h，解冻时长4h，通过冷冻交联方式反复冷冻解冻三次。
复合水凝胶背层负压处理时长为5s，密闭静置时长3h。
实施例3
一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，采用如下步骤：
a、在每百毫升去离子水中加入9g聚乙烯醇，搅拌4h后冷却至室温得到聚乙烯醇溶液，去离子水的温度为95℃；
b、将质量体积比为4mg/ml的氧化石墨烯溶液加入聚乙烯醇溶液中，室温搅拌19h制得反应液，聚乙烯醇溶液与氧化石墨烯溶液的体积比为1:0.9；
c、将反应液转移至玻璃容器中密封，并在零下18℃中冷冻，然后在室温下解冻，反复循环冷冻解冻后得到复合水凝胶；
d、将复合水凝胶的背层喷涂硅酸凝胶，并在68℃脱水老化4h；
e、将臭氧油滴在复合水凝胶的里层，复合水凝胶的背层负压处理后密闭静置，臭氧油与聚乙烯醇溶液的体积比为1:4，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。
反应液在玻璃容器中冷冻时长20h，解冻时长4h，通过冷冻交联方式反复冷冻解冻三次。
复合水凝胶背层负压处理时长为5s，密闭静置时长3h。
具体实施过程中，臭氧油选用湖南海贽医疗科技有限公司生产的海贽臭氧抑菌油。
常见的病原菌依次为金黄色葡萄球菌、溶血性链球菌、凝固酶阴性葡萄球菌+耐甲氧西林葡萄球菌、铜绿假单胞菌+阴沟肠杆菌、草绿凝球菌+凝固酶阴性葡萄球菌、白假丝酵母菌、粪肠球菌，大肠杆菌等细菌感染。
创面细菌培养结果回报，臭氧油水凝胶复合敷贴51例、另一组水凝胶敷贴54例均为阳性，两组均依据药敏结果予静脉滴注抗生素治疗5天，5天后复查创面细菌培养，结果水凝胶负载臭氧油复合敷贴组中有45例培养结果转为阴性；水凝胶敷贴组中只有20例培养结果转为阴性(见表1)，细菌培养阳性患者仍需继续抗生素治疗；经治疗2周，两组创面愈合情况比较(见表2)；两种敷贴治疗前后疼痛评分比较(见表3)。
表1两组治疗前后创面分泌物细菌检测阳性率(％)
Figure BDA0002965978730000061
注：治疗前差异无统计学意义，P＞0.05；治疗后3d、5d、7d、10d差异均有统计学意义，P＜0.05。
表2两组创面愈合率比较
Figure BDA0002965978730000062
表3两种敷贴治疗前后疼痛评分比较(
Figure BDA0002965978730000063
分)
Figure BDA0002965978730000064
Figure BDA0002965978730000071
经不同时间点的独立样本t检验，发现治疗前水凝胶敷贴与臭氧油水凝胶复合敷贴无统计学差异，经治疗后3天、7天、2周均有统计学差异，且水凝胶敷贴的疼痛评分均高于臭氧油水凝胶复合敷贴。
Figure BDA0002965978730000072
经过重复测量的方差分析，不同时间的疼痛评分有统计学差异，不同组别的的疼痛评分有统计学差异，且不同时间与不同组别间存在交互作用。

Claims (3)

1.一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，其特征在于：采用如下步骤：
a、在每百毫升去离子水中加入8-12g聚乙烯醇，搅拌2-5h后冷却至室温得到聚乙烯醇溶液，去离子水的温度为92-96℃；
b、将质量体积比为4mg/ml的氧化石墨烯溶液加入聚乙烯醇溶液中，室温搅拌12-24h制得反应液，聚乙烯醇溶液与氧化石墨烯溶液的体积比为1:0.5-2；
c、将反应液转移至玻璃容器中密封，并在零下15-20℃中冷冻，然后在室温下解冻，反复循环冷冻解冻后得到复合水凝胶；
d、将复合水凝胶的背层喷涂硅酸凝胶，并在60-70℃脱水老化3-5h；
e、将臭氧油滴在复合水凝胶的里层，复合水凝胶的背层负压处理后密闭静置，臭氧油与聚乙烯醇溶液的体积比为1:3-6，完成杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备。
2.根据权利要求1所述的一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，其特征在于：反应液在玻璃容器中冷冻时长20h，解冻时长4h，通过冷冻交联方式反复冷冻解冻三次。
3.根据权利要求1或2所述的一种杀菌抗病毒吸湿的臭氧油水凝胶复合敷贴的制备方法，其特征在于：复合水凝胶背层负压处理时长为5s，密闭静置时长3h。
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