CN112933109A - Vagina pH regulator and preparation method and application thereof - Google Patents

Vagina pH regulator and preparation method and application thereof Download PDF

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CN112933109A
CN112933109A CN202110151375.8A CN202110151375A CN112933109A CN 112933109 A CN112933109 A CN 112933109A CN 202110151375 A CN202110151375 A CN 202110151375A CN 112933109 A CN112933109 A CN 112933109A
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vaginal
vagina
regulator
stirring
urea
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邓礼平
尹燕华
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Hunan Aolangte Medical Equipment Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Abstract

The invention relates to the technical field of medicines, and discloses a vagina pH regulator and a preparation method and application thereof. The pH regulator for vagina contains glucose, urea, potassium hydroxide, carbomer, glycerol, lactic acid, citric acid, tartaric acid, preservative and water. The pH regulator of the vagina can regulate the pH value of the vagina within a normal range of 3.5-4.5, resist and inhibit the growth of pathogenic bacteria, maintain the healthy environment of microorganisms in the vagina, and effectively regulate the pH value even in the presence of semen, thereby maintaining an acidic environment which is not suitable for the survival of sperms and virus and bacterial pathogens related to sexually transmitted infection but is essential for the survival of healthy bacteria in the vagina.

Description

Vagina pH regulator and preparation method and application thereof
Technical Field
The invention relates to the technical field of medicines, in particular to a vagina pH regulator and a preparation method and application thereof.
Background
Vaginal fluid consists of plasma exudate from the vaginal wall, glandular secretions, cervical mucus, endometrial and fallopian tubes fluid, as well as residual urine and exfoliated epithelial cells, the nature and composition of which largely determines the interaction between the microbiota and urogenital pathogens. The vaginal fluid contains water organic matters, inorganic salts, urea, carbohydrates, mucin, fatty acids, albumin, immunoglobulin and other macromolecules, the carbohydrates of the vaginal fluid contain a small amount of mannose and glucosamine besides main glucose, the organic acids also contain a small amount of ions such as formic acid, succinic acid, propionic acid, butyric acid, sodium, potassium, chlorine, calcium and the like besides main lactic acid and acetic acid, and the secretions cooperate with microbial flora to maintain vaginal environment balance. Lactic acid is a main substance for maintaining a weak acid environment with a pH value less than or equal to 4.5 in the vagina, and is beneficial to the growth and the propagation of probiotic lactobacillus vaginalis under the acidity, resists and inhibits the growth of pathogenic bacteria, and maintains the health of the microbial environment in the vagina.
Affected by age, pregnancy and external factors, the microbial community in the vagina of a woman is changed, the vaginal cleanliness and pH are changed, vaginal flora is imbalanced, and further vaginal inflammation is caused; or due to the fact that some factors cause the estrogen level to be reduced, the glycogen content in the epithelial cells is reduced, the generation of lactic acid is reduced, the pH value of the vagina is increased, when the pH value in the vagina is larger than 5.0, the growth and the reproduction of lactobacillus in the vagina are inhibited, and finally, pathogenic bacteria invade and reproduce, so that inflammation is caused; and after sexual life, in the presence of semen in the vagina (which generally raises the vaginal pH to 7.0-8.0), healthy bacteria lose their dominance, leading to the invasion of certain viral and bacterial pathogens associated with sexually transmitted infections, which in turn causes a range of diseases.
Therefore, it is necessary and urgent to develop a product for adjusting the pH of female vagina safely and effectively.
Disclosure of Invention
The invention aims to overcome the problem of lacking a product capable of safely and effectively adjusting the pH value of a female vagina in the prior art, and provides a vagina pH adjusting agent, a preparation method and application thereof, wherein the vagina pH adjusting agent can adjust the vagina pH value within a normal range of 3.5-4.5, and can effectively adjust the pH value even in the presence of semen, so that an acidic environment which is not suitable for sperms and certain virus and bacterial pathogens related to sexually transmitted infection but is essential for healthy bacterial survival in the vagina is maintained.
In order to achieve the above objects, according to one aspect of the present invention, there is provided a vaginal pH adjustor comprising glucose, urea, potassium hydroxide, carbomer, glycerin, lactic acid, citric acid, tartaric acid, a preservative and water.
Preferably, the vaginal pH regulator comprises 4-6 wt% of glucose, 2-3 wt% of urea, 2-5 wt% of potassium hydroxide, 34-42 wt% of carbomer, 2.5-6.5 wt% of glycerin, 2.5-4 wt% of lactic acid, 4-5.5 wt% of citric acid, 1.5-3 wt% of tartaric acid, 1.5-2.5 wt% of preservative and 30-40 wt% of water.
Further preferably, the vaginal pH regulator comprises 4.5-5 wt% of glucose, 2.5-2.75 wt% of urea, 2.5-4.5 wt% of potassium hydroxide, 35-41 wt% of carbomer, 3-6.25 wt% of glycerin, 2.75-3.8 wt% of lactic acid, 4.5-5.2 wt% of citric acid, 1.75-2.3 wt% of tartaric acid, 1.75-2.25 wt% of a preservative, and 31-39 wt% of water.
Preferably, the preservative is at least one of methylparaben, sodium propylparaben, imidazolidinyl urea and sodium lactate.
Preferably, the water is distilled water.
In a second aspect, the present invention provides a method for preparing the above-mentioned vaginal pH adjustor, comprising the steps of:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and a preservative into the mixed solution obtained in the step (2) and stirring to obtain the vaginal pH regulator.
Preferably, in step (1), the temperature of the stirring is 22 to 28 ℃.
Preferably, in step (1), the stirring time is 30-40 min.
Preferably, in step (1), the stirring speed is 55-65 rpm.
In a third aspect, the present invention provides the use of a vaginal pH modifier as hereinbefore described for modifying the pH of the vagina.
The pH regulator of the vagina can regulate the pH value of the vagina within a normal range of 3.5-4.5, resists and inhibits the growth of pathogenic bacteria, maintains the healthy environment of microorganisms in the vagina, is safe and effective, and can also effectively regulate the pH value even in the presence of semen, thereby maintaining an acidic environment which is not suitable for the existence of sperms and virus and bacterial pathogens related to sexually transmitted infection but is essential for the existence of healthy bacteria in the vagina.
Detailed Description
The following describes in detail specific embodiments of the present invention. It should be understood that the detailed description and specific examples, while indicating the present invention, are given by way of illustration and explanation only, not limitation.
The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.
The invention provides a vagina pH regulator, which contains glucose, urea, potassium hydroxide, carbomer, glycerol, lactic acid, citric acid, tartaric acid, a preservative and water.
Preferably, the vaginal pH regulator comprises 4-6 wt% glucose, 2-3 wt% urea, 2-5 wt% potassium hydroxide, 34-42 wt% carbomer, 2.5-6.5 wt% glycerol, 2.5-4 wt% lactic acid, 4-5.5 wt% citric acid, 1.5-3 wt% tartaric acid, 1.5-2.5 wt% preservative and 30-40 wt% water.
Further preferably, the vaginal pH regulator comprises 4.5-5 wt% of glucose, 2.5-2.75 wt% of urea, 2.5-4.5 wt% of potassium hydroxide, 35-41 wt% of carbomer, 3-6.25 wt% of glycerin, 2.75-3.8 wt% of lactic acid, 4.5-5.2 wt% of citric acid, 1.75-2.3 wt% of tartaric acid, 1.75-2.25 wt% of a preservative, and 31-39 wt% of water.
In the present invention, there is no particular requirement for the selection of the preservative, and it may be a routine choice in the art. In a preferred embodiment, the preservative is at least one of methylparaben, sodium propylparaben, imidazolidinyl urea and sodium lactate.
In the present invention, the water is distilled water.
In a second aspect, the present invention provides a method for preparing the above-mentioned vaginal pH adjustor, comprising the steps of:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and a preservative into the mixed solution obtained in the step (2) and stirring to obtain the vaginal pH regulator.
In the present invention, in the step (1), the temperature of the stirring is 22 to 28 ℃. Specifically, the temperature of the stirring may be 22 ℃, 23 ℃, 24 ℃, 25 ℃, 26 ℃, 27 ℃ or 28 ℃.
In the invention, in the step (1), the stirring time is 30-40 min. Specifically, the stirring time may be 30min, 31min, 32min, 33min, 34min, 35min, 36min, 37min, 38min, 39min, or 40 min.
In the present invention, in the step (1), the stirring speed is 55 to 65 rpm. Specifically, the stirring speed may be 55rpm, 56rpm, 57rpm, 58rpm, 59rpm, 60rpm, 61rpm, 62rpm, 63rpm, 64rpm, or 65 rpm.
In a third aspect, the present invention provides the use of a vaginal pH modifier as hereinbefore described for modifying the pH of the vagina.
The pH regulator of the vagina can regulate the pH value of the vagina within a normal range of 3.5-4.5, resists and inhibits the growth of pathogenic bacteria, maintains the healthy environment of microorganisms in the vagina, is safe and effective, and can also effectively regulate the pH value even in the presence of semen, thereby maintaining an acidic environment which is not suitable for the existence of sperms and virus and bacterial pathogens related to sexually transmitted infection but is essential for the existence of healthy bacteria in the vagina.
The present invention will be described in detail by way of examples, but the scope of the present invention is not limited thereto.
Example 1
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and antiseptic (methyl parahydroxybenzoate) into the mixed solution obtained in step (2), stirring (stirring temperature is 22 deg.C, stirring time is 40min, and stirring speed is 60rpm) to obtain vaginal pH regulator A1;
wherein the vaginal pH regulator A1 contains 4.89 wt% glucose, 2.6 wt% urea, 4 wt% potassium hydroxide, 40 wt% carbomer, 5 wt% glycerin, 3 wt% lactic acid, 5 wt% citric acid, 2 wt% tartaric acid, 1.81 wt% preservative, and 31.7 wt% water.
Example 2
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and preservative (sodium propyl p-hydroxybenzoate) into the mixed solution obtained in the step (2), and stirring (stirring temperature is 28 ℃, stirring time is 35min, and stirring speed is 55rpm) to obtain a vaginal pH regulator A2;
wherein the vaginal pH regulator A2 contains 4.89 wt% glucose, 2.66 wt% urea, 3.1 wt% potassium hydroxide, 37 wt% carbomer, 3.4 wt% glycerin, 2.75 wt% lactic acid, 5.2 wt% citric acid, 2 wt% tartaric acid, 2 wt% preservative and 37 wt% water.
Example 3
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and preservative (imidazolidinyl urea) into the mixed solution obtained in the step (2), and stirring (the stirring temperature is 25 ℃, the stirring time is 30min, and the stirring speed is 65rpm) to obtain a vaginal pH regulator A3;
wherein the vaginal pH regulator A3 comprises 4.89 wt% glucose, 2.54 wt% urea, 2.9 wt% potassium hydroxide, 35 wt% carbomer, 5.59 wt% glycerol, 3.8 wt% lactic acid, 4.5 wt% citric acid, 1.75 wt% tartaric acid, 2.01 wt% preservative and 37.02 wt% water.
Example 4
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and antiseptic (sodium lactate) into the mixed solution obtained in step (2), and stirring (stirring temperature is 24 deg.C, stirring time is 38min, and stirring speed is 57rpm) to obtain vaginal pH regulator A4;
wherein the vaginal pH regulator A4 contains 4.91 wt% glucose, 2.62 wt% urea, 3.7 wt% potassium hydroxide, 36 wt% carbomer, 4.77 wt% glycerin, 2.98 wt% lactic acid, 4.75 wt% citric acid, 2.3 wt% tartaric acid, 2.02 wt% preservative and 35.95 wt% water.
Example 5
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and antiseptic (sodium lactate) into the mixed solution obtained in step (2), and stirring (stirring temperature is 26 deg.C, stirring time is 33min, and stirring speed is 61rpm) to obtain vaginal pH regulator A5;
wherein the vaginal pH regulator A5 comprises glucose 4.54 wt%, urea 2.52 wt%, potassium hydroxide 4.02 wt%, carbomer 39 wt%, glycerol 6.08 wt%, lactic acid 3.59 wt%, citric acid 4.66 wt%, tartaric acid 2.01 wt%, preservative 2.19 wt% and water 31.39 wt%.
Comparative example 1
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding citric acid, tartaric acid and antiseptic (methyl p-hydroxybenzoate) into the mixed solution obtained in step (2), and stirring (stirring temperature is 22 deg.C, stirring time is 40min, and stirring speed is 60rpm) to obtain vaginal pH regulator D1;
wherein the vaginal pH regulator D1 contains 4.89 wt% of glucose, 2.6 wt% of urea, 4 wt% of potassium hydroxide, 40 wt% of carbomer, 5 wt% of glycerol, 5 wt% of citric acid, 2 wt% of tartaric acid, 1.81 wt% of preservative and 34.7 wt% of water.
Comparative example 2
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, tartaric acid and antiseptic (methyl p-hydroxybenzoate) into the mixed solution obtained in step (2), and stirring (stirring temperature is 22 deg.C, stirring time is 40min, and stirring speed is 60rpm) to obtain vaginal pH regulator D2;
wherein the vaginal pH regulator D2 contains 4.89 wt% of glucose, 2.6 wt% of urea, 4 wt% of potassium hydroxide, 40 wt% of carbomer, 5 wt% of glycerol, 3 wt% of lactic acid, 2 wt% of tartaric acid, 1.81 wt% of preservative and 36.7 wt% of water.
Comparative example 3
The preparation method comprises the following steps:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into distilled water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid and preservative (methyl p-hydroxybenzoate) into the mixed solution obtained in the step (2), and stirring (stirring temperature is 22 ℃, stirring time is 40min, and stirring speed is 60rpm) to obtain a vaginal pH regulator D3;
wherein the vaginal pH regulator D3 contains 4.89 wt% of glucose, 2.6 wt% of urea, 4 wt% of potassium hydroxide, 40 wt% of carbomer, 5 wt% of glycerol, 3 wt% of lactic acid, 5 wt% of citric acid, 1.81 wt% of preservative and 33.7 wt% of water.
Test example 1
Skin irritation test
Test subjects: selecting 50 healthy adult rabbits, dividing into 5 groups of 10 rabbits, and shaving 4 parts of the back of each rabbit by 9cm2。
The test method comprises the following steps: the vaginal pH regulators prepared in examples 1 to 5 were applied to the shaved area of 10 rabbits every 8 hours, and the applied area was observed for 8 hours, 16 hours, 24 hours, 48 hours, and 72 hours.
And (3) test results: no local irritation reactions such as skin erythema, edema and the like appear in 50 tested rabbits, which shows that the vagina pH regulator prepared by the invention is safe and non-irritant and has no adverse reaction.
Test example 2
Test for pH-adjusting ability
100mL of the vaginal pH adjustor in each of examples 1 to 5 and comparative examples 1 to 3 was taken, the pH value thereof was measured, 5mL of a phosphate solution having a pH of 5.5 was added thereto each time several times, and the pH of the solution after each addition was measured each time.
TABLE 1
Figure BDA0002932034840000111
Figure BDA0002932034840000121
As can be seen from the results in Table 1, the pH regulator for vagina prepared in the examples can effectively maintain stable pH, which shows that the pH regulator for vagina of the invention can better maintain the pH within the normal physiological range.
Test example 3
Test for pH-adjusting ability
100mL of the vaginal pH adjustor in each of examples 1 to 5 and comparative examples 1 to 3 was taken, the pH value thereof was measured, 5mL of a phosphate solution having a pH of 6.5 was added thereto each time several times, and the pH of the solution after each addition was measured.
TABLE 2
Figure BDA0002932034840000122
Figure BDA0002932034840000131
As can be seen from the results in Table 2, the pH regulator for vagina prepared in the examples can effectively maintain the pH to be stable, which shows that the pH regulator for vagina of the invention can better maintain the pH to be in a normal physiological range even under the condition of weak pathological alkaline environment.
Test example 4
Test for pH-adjusting ability
100mL of the vaginal pH adjustor in each of examples 1 to 5 and comparative examples 1 to 3 was taken, the pH value thereof was measured, 5mL of a phosphate solution having a pH of 7.8 was added thereto each time several times, and the pH of the solution after each addition was measured.
TABLE 3
Figure BDA0002932034840000132
Figure BDA0002932034840000141
As can be seen from the results in Table 3, the pH regulator for vagina prepared in the examples can effectively maintain stable pH, which indicates that the pH regulator for vagina of the present invention can better maintain the pH within the normal physiological range.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.

Claims (10)

1. A vaginal pH regulator is characterized by comprising glucose, urea, potassium hydroxide, carbomer, glycerol, lactic acid, citric acid, tartaric acid, a preservative and water.
2. The vaginal pH regulator according to claim 1, wherein the vaginal pH regulator comprises 4 to 6% by weight of glucose, 2 to 3% by weight of urea, 2 to 5% by weight of potassium hydroxide, 34 to 42% by weight of carbomer, 2.5 to 6.5% by weight of glycerin, 2.5 to 4% by weight of lactic acid, 4 to 5.5% by weight of citric acid, 1.5 to 3% by weight of tartaric acid, 1.5 to 2.5% by weight of a preservative, and 30 to 40% by weight of water.
3. The vaginal pH adjustor of claim 2, wherein the vaginal pH adjustor comprises 4.5-5 wt% of glucose, 2.5-2.75 wt% of urea, 2.5-4.5 wt% of potassium hydroxide, 35-41 wt% of carbomer, 3-6.25 wt% of glycerin, 2.75-3.8 wt% of lactic acid, 4.5-5.2 wt% of citric acid, 1.75-2.3 wt% of tartaric acid, 1.75-2.25 wt% of preservative, and 31-39 wt% of water.
4. The vaginal pH adjustor of claim 1, wherein the preservative is at least one of methylparaben, sodium propylparaben, imidazolidinyl urea and sodium lactate.
5. The vaginal pH adjustor of claim 1, wherein the water is distilled water.
6. A method for preparing the vaginal pH adjustor of any one of claims 1-5, wherein the method comprises the steps of:
(1) adding glucose, urea, potassium hydroxide, carbomer and glycerol into water, and stirring to obtain a mixed solution;
(2) adding lactic acid, citric acid, tartaric acid and a preservative into the mixed solution obtained in the step (2) and stirring to obtain the vaginal pH regulator.
7. The method according to claim 6, wherein in step (1), the temperature of the stirring is 22-28 ℃.
8. The method according to claim 6 or 7, wherein in step (1), the stirring time is 30-40 min.
9. The method according to claim 8, wherein in step (1), the stirring speed is 55-65 rpm.
10. Use of the vaginal pH modifier of any one of claims 1-5 for the adjustment of vaginal pH.
CN202110151375.8A 2021-02-03 2021-02-03 Vagina pH regulator and preparation method and application thereof Pending CN112933109A (en)

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CN114306108A (en) * 2022-01-17 2022-04-12 北京图灵微研生物科技有限公司 Nursing agent for balancing gynecological microecological flora structure

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Application publication date: 20210611