CN115998721A - Cleaning antibacterial liquid and preparation method thereof - Google Patents
Cleaning antibacterial liquid and preparation method thereof Download PDFInfo
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- CN115998721A CN115998721A CN202310117426.4A CN202310117426A CN115998721A CN 115998721 A CN115998721 A CN 115998721A CN 202310117426 A CN202310117426 A CN 202310117426A CN 115998721 A CN115998721 A CN 115998721A
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- fatty alcohol
- polyoxyethylene ether
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- alcohol polyoxyethylene
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a cleaning antibacterial liquid and a preparation method thereof, wherein the cleaning antibacterial liquid comprises lactic acid, fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut diethanolamide, cocamidopropyl amine oxide, a humectant and purified water. The cleaning antibacterial liquid is viscous liquid, takes lactic acid as a main antibacterial component, takes fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut diethanolamide and cocoamidopropyl amine oxide as surfactants, is suitable for cleaning and antibacterial of human skin, and has the advantages of no pollution, no stimulation, fine foam and easy flushing. The preparation method is simple and easy to implement, the surfactants are crosslinked into viscous liquid during production, no viscous agent is required to be added, the production is easy, the product is stable, and the preparation method is suitable for industrial mass production.
Description
Technical Field
The invention belongs to the technical field of disinfection products, and relates to a cleaning liquid, in particular to a female cleaning antibacterial liquid and a preparation method thereof.
Background
Lactic acid, also called 2-hydroxy propionic acid, is an important organic acid, and can be used as raw material, additive, preservative, disinfectant, regulator, etc. and can be widely used in the fields of brewing, food, cosmetics, medicine, textile, environmental protection, etc. Currently, lactic acid is mainly prepared by fermentation, about 90% of commercially available lactic acid is prepared by microbial fermentation and is easily biodegradable in the environment. The research shows that the common pathogenic bacteria (such as escherichia coli, staphylococcus aureus, candida albicans and pseudomonas aeruginosa) in the lactic acid hospital have certain inhibition and killing effects, the action principle of the lactic acid hospital is to kill the pathogenic bacteria mainly by prolonging the generation time of the pathogenic bacteria and destroying the normal cell membrane points, and the lactic acid hospital is used for fumigation in an operating room of the hospital, and is a pollution-free sterilization raw material.
Gynecological diseases are common diseases of women, affect the health and safety of human bodies and bring inconvenience to normal work. The vaginal pH is one of the important indicators of female gynecopathy in hospital examinations. Normal flora in the vagina is distributed on the side wall of the vagina, the most main resident bacteria are lactobacillus which can generate hydrogen peroxide, and lactic acid is generated by degrading glycogen, so that certain acidity is kept in the vagina, the growth of anaerobic bacteria is inhibited, and the flora balance in the vagina is maintained. Related studies have shown that women of childbearing age with a normal menstrual cycle have a vaginal pH of 3.5 to 4.5 in the absence of vaginal infection. When pathogenic bacteria invade, the living space of the lactobacillus is extruded, so that the lactobacillus is reduced or glycogen is reduced, and the pH value of vagina is raised due to insufficient lactic acid secretion.
At present, the common female antibacterial cleaning agent on the market usually takes traditional Chinese medicine extracts as main components, the main components of the product usually comprise more than 4 different traditional Chinese medicine components, such as a herbal antibacterial liquid with patent publication No. CN102614440A, and the main components are extracted from 38 traditional Chinese medicine extracts; the medicines are of too many kinds, complex in components and undefined in active ingredients, and are easy to generate certain irritation to vaginal mucosa.
Patent publication No. CN101396507A discloses a traditional Chinese medicine antibacterial liquid, and a preparation method and application thereof. The antibacterial cleaning agent is also prepared from 20 traditional Chinese medicines through multiple ethanol extraction, the final alcohol concentration of the product is 35-45%, the ethanol with the concentration has a certain antibacterial effect, the antibacterial effect of the product cannot be judged to be obtained through the action of ethanol or a traditional Chinese medicine extract, and meanwhile, the antibacterial effect of the antibacterial cleaning agent for antibacterial females in actual use cannot be judged without related antibacterial experiments.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a product with two functions of cleaning and bacteriostasis, and the preparation method of the disinfectant has the advantages of stability, good bacteriostasis effect, easy flushing, safety, no pollution and suitability for industrial mass production.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a cleaning and bacteriostatic liquid, comprising: lactic acid, fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut diethanolamide, cocamidopropyl amine oxide, a humectant and purified water.
As a preferable scheme of the invention, the cleaning antibacterial liquid comprises, by weight, 0.1-3.0 parts of lactic acid, 1.0-8.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 1.0-7.0 parts of fatty alcohol polyoxyethylene ether glucoside, 0.5-8.0 parts of coconut diethanolamide, 0.1-0.8 parts of cocoamidopropyl amine oxide, 0.1-1.0 parts of humectant and 80.0-98 parts of purified water.
As a preferable scheme of the invention, the cleaning antibacterial liquid comprises, by weight, 0.3-1.5 parts of lactic acid, 2.0-6.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 2.0-5.0 parts of fatty alcohol polyoxyethylene ether glucoside, 1.0-6.0 parts of coconut diethanolamide, 0.2-0.6 parts of cocoamidopropyl amine oxide, 0.1-0.8 parts of humectant and 84.0-95 parts of purified water.
As a preferable scheme of the invention, the cleaning antibacterial liquid comprises, by weight, 0.3-1.0 part of lactic acid, 2.0-5.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 2.0-4.0 parts of fatty alcohol polyoxyethylene ether glucoside, 2.0-5.0 parts of coconut diethanolamide, 0.2-0.5 parts of cocoamidopropyl amine oxide, 0.1-0.5 part of humectant and 84.0-93.4 parts of purified water.
As a preferable scheme of the invention, the humectant is one or a mixture of a plurality of glycerin, propylene glycol and polyethylene glycol.
The invention also provides a preparation method of the cleaning antibacterial liquid, which comprises the following steps:
1) Adding purified water into a container, adding fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside and coconut diethanolamide, and stirring until the components are completely dissolved;
2) Adding the humectant into the system in the step 1) while stirring, and uniformly stirring and dissolving;
3) Adding lactic acid into the system in the step 2) under stirring, and stirring for dissolution;
4) Adjusting the pH;
5) Adding cocamidopropyl amine oxide into the system in the step 4) under stirring, and stirring to dissolve to obtain the cleaning antibacterial liquid.
In a preferred embodiment of the present invention, in step 4), the pH is adjusted to 4.5 to 7.
As a preferred embodiment of the present invention, in the steps 1) to 5), the stirring speed is 200 to 400 rpm.
Compared with the prior art, the invention has the following beneficial effects:
(1) The cleaning antibacterial liquid has a strong antibacterial effect, and the antibacterial rate of the cleaning antibacterial liquid on common infectious bacteria (candida albicans, staphylococcus aureus and escherichia coli) in hospitals for 2 minutes is more than or equal to 99.9 percent.
(2) The cleaning antibacterial liquid disclosed by the invention is fine and smooth in foam and has a good cleaning effect.
(3) The cleaning antibacterial liquid disclosed by the invention is mild in formula, free of stimulation, good in stability, free of pollution to the environment, safe and environment-friendly, and suitable for industrial production.
(4) The invention takes lactic acid as a main antibacterial component, and the weak acid formula is more suitable for women.
Detailed Description
In order to facilitate understanding of the technical means, the creation characteristics, the achievement of the objects and the effects achieved by the present invention, the present invention is further described below with reference to specific examples, but the following examples are only preferred examples of the present invention, not all of which are described in detail below. Based on the examples in the embodiments, those skilled in the art can obtain other examples without making any inventive effort, which fall within the scope of the invention. The experimental methods in the following examples are conventional methods unless otherwise specified, and materials, reagents, etc. used in the following examples are commercially available unless otherwise specified.
Example 1:
the embodiment provides a cleaning antibacterial liquid, which comprises the following raw materials in percentage by mass: 0.5g of lactic acid, 2.5g of fatty alcohol polyoxyethylene ether ammonium sulfate, 3.0g of fatty alcohol polyoxyethylene ether glucoside, 2.0g of coconut diethanolamide, 0.2g of cocoamidopropyl amine oxide, 0.2g of humectant and 91.6g of purified water.
The production method of the cleaning antibacterial liquid comprises the following specific steps:
(1) 91.6g of purified water, 2.5g of fatty alcohol-polyoxyethylene ether ammonium sulfate, 3.0g of fatty alcohol-polyoxyethylene ether glucoside and 2.0g of coconut diethanolamide are added into a container, and the mixture is stirred at a low speed until the mixture is completely dissolved.
(2) 0.2g of humectant is added while stirring, and the mixture is stirred and dissolved uniformly.
(3) While stirring, 0.5g of lactic acid was added thereto, and the mixture was dissolved by stirring.
(4) While stirring, 0.2g of cocamidopropyl amine oxide was added thereto and dissolved with stirring.
Example 2:
the embodiment provides a cleaning antibacterial liquid, which comprises the following raw materials in percentage by mass: 0.6g of lactic acid, 3.0g of fatty alcohol polyoxyethylene ether ammonium sulfate, 2.0g of fatty alcohol polyoxyethylene ether glucoside, 2.0g of coconut diethanolamide, 0.3g of cocoamidopropyl amine oxide, 0.3g of humectant and 91.8g of purified water.
The production method of the cleaning antibacterial liquid comprises the following specific steps:
(1) 91.8g of purified water was added to the vessel, 3.0g of ammonium polyoxyethylene fatty alcohol sulfate, 2.0g of polyoxyethylene fatty alcohol glucoside, and 2.0g of coconut diethanolamide were added, and the mixture was stirred at a low speed until the mixture was completely dissolved.
(2) 0.3g of humectant is added while stirring, and the mixture is stirred and dissolved uniformly.
(3) While stirring, 0.6g of lactic acid was added thereto, and the mixture was dissolved by stirring.
(4) While stirring, 0.3g of cocamidopropyl amine oxide was added thereto and dissolved with stirring.
Example 3:
the embodiment provides a cleaning antibacterial liquid, which comprises the following raw materials in percentage by mass: 0.7g of lactic acid, 3.0g of fatty alcohol polyoxyethylene ether ammonium sulfate, 3.0g of fatty alcohol polyoxyethylene ether glucoside, 1.5g of coconut diethanolamide, 0.3g of cocoamidopropyl amine oxide, 0.2g of humectant and 91.3g of purified water.
The production method of the cleaning antibacterial liquid comprises the following specific steps:
(1) 91.3g of purified water, 3.0g of fatty alcohol-polyoxyethylene ether ammonium sulfate, 3.0g of fatty alcohol-polyoxyethylene ether glucoside and 1.5g of coconut diethanolamide are added into a container, and the mixture is stirred at a low speed until the mixture is completely dissolved.
(2) 0.2g of humectant is added while stirring, and the mixture is stirred and dissolved uniformly.
(3) While stirring, 0.7g of lactic acid was added thereto, and the mixture was dissolved by stirring.
(4) While stirring, 0.3g of cocamidopropyl amine oxide was added thereto and dissolved with stirring.
Test example:
in order to verify the safety, no irritation and bacteriostasis of the product, the cleaning bacteriostasis liquid of the embodiment 1 is measured by a third-party authority detection mechanism and is used for testing the sterilization effect, and the disposable complete skin irritation test and the disposable vaginal mucosa irritation test are carried out.
The procedure and results of the test are as follows:
the detection method comprises the following steps: the action time is 2, 5, 10 and 20 minutes according to GB15979-2002 hygienic Standard for Disposable hygienic products.
(1) The test results are shown in Table 1 below:
TABLE 1 antibacterial effect of samples on test strains
Test conclusion: the test sample has strong antibacterial effect on candida albicans, staphylococcus aureus and escherichia coli for 2, 5, 10 and 20 minutes, and the antibacterial rate is more than 99.9 percent.
(2) The results of the one-time, full skin irritation test of the sample cleaning and bacteriostatic fluid are shown in Table 2 below.
TABLE 2 test subject one-time complete skin irritation response score for New Zealand rabbits
Test conclusion: the average stimulation index of the test rabbit is 0.00 in a plurality of skin stimulation tests, and the test rabbit has no stimulation to one-time complete skin stimulation.
(3) The results of the sample cleaning antibacterial liquid disposable vaginal mucosa irritation test are shown in the following table 3.
TABLE 3 results of test substance to Rabbit one-time vaginal mucosa irritation response scoring
Test conclusion: the reaction strength of the test object to the rabbit vaginal mucosa stimulation is as follows: and no.
While the invention has been described with respect to preferred embodiments thereof, it will be understood by those skilled in the art that various modifications and additions may be made without departing from the scope of the invention. Equivalent embodiments of the present invention will be apparent to those skilled in the art having the benefit of the teachings disclosed herein, when considered in the light of the foregoing disclosure, and without departing from the spirit and scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.
Claims (8)
1. The cleaning antibacterial liquid is characterized by comprising the following components in percentage by weight: lactic acid, fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut diethanolamide, cocamidopropyl amine oxide, a humectant and purified water.
2. The cleaning and bacteriostasis liquid according to claim 1, which is characterized by comprising, by weight, 0.1-3.0 parts of lactic acid, 1.0-8.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 1.0-7.0 parts of fatty alcohol polyoxyethylene ether glucoside, 0.5-8.0 parts of coconut diethanolamide, 0.1-0.8 parts of cocamidopropyl amine oxide, 0.1-1.0 parts of humectant and 80.0-98 parts of purified water.
3. The cleaning and bacteriostasis liquid according to claim 1, which is characterized by comprising, by weight, 0.3-1.5 parts of lactic acid, 2.0-6.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 2.0-5.0 parts of fatty alcohol polyoxyethylene ether glucoside, 1.0-6.0 parts of coconut diethanolamide, 0.2-0.6 parts of cocamidopropyl amine oxide, 0.1-0.8 parts of humectant and 84.0-95 parts of purified water.
4. The cleaning and bacteriostasis liquid according to claim 1, which is characterized by comprising, by weight, 0.3-1.0 part of lactic acid, 2.0-5.0 parts of fatty alcohol polyoxyethylene ether ammonium sulfate, 2.0-4.0 parts of fatty alcohol polyoxyethylene ether glucoside, 2.0-5.0 parts of coconut diethanolamide, 0.2-0.5 parts of cocamidopropyl amine oxide, 0.1-0.5 parts of humectant and 84.0-93.4 parts of purified water.
5. The cleaning and bacteriostasis liquid according to any one of claims 1 to 4, wherein the humectant is one or a mixture of several of glycerin, propylene glycol and polyethylene glycol.
6. A method of preparing a cleaning and bacteriostatic fluid according to any one of claims 1-5, comprising the steps of:
1) Adding purified water into a container, adding fatty alcohol polyoxyethylene ether ammonium sulfate, fatty alcohol polyoxyethylene ether glucoside and coconut diethanolamide, and stirring until the components are completely dissolved;
2) Adding the humectant into the system in the step 1) while stirring, and uniformly stirring and dissolving;
3) Adding lactic acid into the system in the step 2) under stirring, and stirring for dissolution;
4) Adjusting the pH;
5) Adding cocamidopropyl amine oxide into the system in the step 4) under stirring, and stirring to dissolve to obtain the cleaning antibacterial liquid.
7. The method for producing a cleansing antibacterial liquid according to claim 6, wherein in step 4), the pH is adjusted to 4.5 to 7.
8. The method for preparing a cleaning and bacteriostasis liquid according to claim 6, wherein in the steps 1) to 5), the stirring speed is 200 to 400 rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310117426.4A CN115998721A (en) | 2023-02-15 | 2023-02-15 | Cleaning antibacterial liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310117426.4A CN115998721A (en) | 2023-02-15 | 2023-02-15 | Cleaning antibacterial liquid and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN115998721A true CN115998721A (en) | 2023-04-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310117426.4A Pending CN115998721A (en) | 2023-02-15 | 2023-02-15 | Cleaning antibacterial liquid and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN115998721A (en) |
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2023
- 2023-02-15 CN CN202310117426.4A patent/CN115998721A/en active Pending
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