CN112881742A - Ultraviolet laser liquid self-driven platform - Google Patents

Ultraviolet laser liquid self-driven platform Download PDF

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Publication number
CN112881742A
CN112881742A CN202110136282.8A CN202110136282A CN112881742A CN 112881742 A CN112881742 A CN 112881742A CN 202110136282 A CN202110136282 A CN 202110136282A CN 112881742 A CN112881742 A CN 112881742A
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laser
substrate
module
liquid
pdms
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CN202110136282.8A
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邓宇
钟世裕
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Guangdong University of Technology
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Guangdong University of Technology
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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Abstract

The invention discloses an ultraviolet laser liquid self-driven platform which mainly comprises a laser, a computer, a control module, a reflector, a lens, a glass cover, a substrate and a moving module, wherein the computer is connected with the laser; the control module is connected with the laser; the computer is respectively connected with the control module and the mobile module; the substrate is arranged on the moving module; the glass cover is arranged on the movable module and covers and seals the substrate; filling ozone in the glass cover; the reflector and the lens are arranged above the moving module. The invention takes PDMS as a substrate, and utilizes the characteristic that the directly cured PDMS has hydrophobicity, and ozone is filled in the dropping liquid while ultraviolet laser is irradiated on one side of the dropping liquid. The hydrophilicity of the laser irradiated area is improved, the contact angle is reduced, and the liquid is pushed to roll by the contact angle difference between the front and the back of the liquid drop. The method can guide the liquid drop to move on the PDMS surface without a channel according to a certain path under the condition of no external driving force by changing the track of the laser on the irradiation area of the PDMS surface.

Description

Ultraviolet laser liquid self-driven platform
Technical Field
The invention relates to the technical field of microfluidics, in particular to an ultraviolet laser liquid self-driven platform.
Background
Microfluidics is a scientific technology for manipulating fluids at the micrometer scale, and can shrink various laboratory functions of biology, chemistry, and the like onto a very small chip, so that the microfluidic chip is also called lab-on-a-chip. The microfluidic has the greatest advantages and characteristics that a plurality of technical units and processes can be connected through microchannels, flexible combination and large-scale integration are realized on a tiny platform, and biological and chemical indexes can be detected quickly, automatically, at high flux and at low cost, so that complex functions of a complete laboratory are realized. Because the size is tiny, the micro-fluidic chip only needs to process trace fluid, and the cost of expensive biochemical detection reagents can be greatly saved. Microfluidic systems are still under rapid development and are being applied in increasingly wider fields. First, detection of almost any analytical chemistry can be accomplished by microfluidic chips. Secondly, with the development and demand of the technology increasing, the development direction of the microfluidic chip in recent years gradually changes to the construction of different types of lab-on-a-chip, thereby being applied to different fields, such as environmental monitoring, medical diagnosis, cytomics and the like. The integrity and systematicness of the microfluidic chip have the potential capability which is difficult to estimate, so that the microfluidic chip has strong development activity and good application prospect.
The traditional manufacturing materials of the microfluidic chip mainly comprise silicon, glass, quartz and the like, but the processing time is long and the cost is high. Polydimethylsiloxane (PDMS) has the characteristics of stable chemical property, good light transmittance, excellent biocompatibility, low price and the like, and has become a preferred material for preparing microfluidic chips. The existing micro-fluidic chip technology is mainly divided into two parts, one is the preparation of the micro-fluidic chip, and the other is the driving of liquid. The chip is manufactured by taking PDMS as a substrate and preparing a micro-channel, a micro-pump and the like on the substrate. The fabrication methods of the micro-channel are various, and mainly include molding, hot pressing, soft lithography, laser ablation, injection molding, and the like. After the micro-channels are prepared, chip bonding can be performed by covering a substrate with micro-channels with a layer of material to form closed micro-channels.
After the microfluidic chip is prepared, power is also required to drive the fluid to flow in the microchannel to the designated reaction or analysis position. Common microfluidic driving technologies in microfluidic chips include differential pressure driving, electric driving, surface tension driving, fluid self-driving, and the like.
The existing microfluidic technology has the main defects of single realization function and small application range. In the above-mentioned techniques, the microstructure of the substrate surface is designed according to a single function, and a corresponding mold is processed according to the microstructure. Since the mold is designed according to a specific function, the adaptability is not strong. In addition, the manufacturing of the mold needs to go through a series of complicated steps, so that the manufacturing period of the microfluidic chip is longer. Secondly, the microfluidic technology can only realize the guide movement of a single liquid drop, and the efficiency is low. In addition, because the driving force is provided by pressure, electricity, light and magnetism at present, a micropump and the like are required to provide power for the outside, so that the workbench has a complex structure and high manufacturing cost. Accordingly, further improvements and improvements are needed in the art.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an ultraviolet laser liquid self-driven platform.
The purpose of the invention is realized by the following technical scheme:
an ultraviolet laser liquid self-driven platform mainly comprises a laser, a computer, a control module, a reflector, a lens, a glass cover, a substrate and a moving module. The control module is connected with the laser and used for controlling and adjusting the parameters of the laser emitted by the laser. And the computer is respectively connected with the control module and the mobile module, and respectively controls the laser emission parameters and sets the liquid self-driving path. The base is installed at the moving end of the moving module and is fixedly connected with the moving module. The glass cover is arranged on the moving module, and covers and seals the substrate. And ozone is filled in the glass cover. The reflector and the lens are arranged above the moving module and are positioned above the substrate.
As a preferable scheme of the invention, the substrate is made of polydimethylsiloxane material, and the surface of the substrate has hydrophobic property.
As a preferable embodiment of the present invention, the surface of the substrate is a plane, and it is not necessary to scribe a micro channel structure for flowing a liquid.
As a preferable scheme of the invention, the mobile module adopts a high-precision three-axis mobile platform.
As a preferable scheme of the invention, the laser can emit a plurality of laser beams, the number of the reflecting mirrors and the lenses is adjusted according to the number of the actual laser beams, and the self-driving of a plurality of liquid drops with different motion tracks guided at a time is realized.
The working process and principle of the invention are as follows: the invention relates to a micro-fluidic platform designed by taking PDMS as a substrate, which utilizes the characteristic that the directly cured PDMS has hydrophobicity, and uses ultraviolet laser to irradiate one side of a dropping liquid and simultaneously fills ozone. The hydrophilicity of the laser irradiated area is improved, the contact angle is reduced, and the liquid is pushed to roll by the contact angle difference between the front and the back of the liquid drop. The method can guide the liquid drop to move on the PDMS surface without a channel according to a certain path under the condition of no external driving force by changing the track of the laser on the irradiation area of the PDMS surface. The invention also has the advantages of simple structure, convenient operation and easy implementation.
Compared with the prior art, the invention also has the following advantages:
(1) the ultraviolet laser liquid self-driving platform provided by the invention does not need to provide driving force from the outside, and realizes liquid drop self-driving by the contact angle between the liquid drop and the surface of PDMS and the gradient difference of the contact angle existing in the liquid drop.
(2) The ultraviolet laser liquid self-driving platform provided by the invention realizes different path movements of liquid drops on the surface of PDMS by controlling the movement track of laser through a laser system, and has good flexibility and adaptability.
(3) The ultraviolet laser liquid self-driven platform provided by the invention does not need to prepare complicated structures such as micro-channels, micro-pumps and the like on PDMS, shortens the production period and reduces the production cost.
(4) The ultraviolet laser liquid self-driving platform provided by the invention can simultaneously drive a plurality of liquid drops to be guided and transported on one PDMS chip, thereby greatly improving the working efficiency.
(5) The ultraviolet laser liquid self-driving platform provided by the invention changes the contact angle between the liquid drop in the laser irradiation area and the surface of the material by irradiating the surface of PDMS with ultraviolet, and guides the liquid drop to roll through the gradient difference existing in the contact angle between the liquid drop and the surface of the material, thereby realizing the self-driving of the liquid drop on the surface of PDMS. Meanwhile, the liquid drop can be guided to move according to a certain path only by adjusting the ultraviolet laser or the working platform, and a new micro-fluidic chip is not required to be designed according to different functions, so that the repeatability of the chip is good, and the cost is saved. Therefore, the technology has stronger applicability and wider application range. The technology does not need to prepare a complicated micro-channel on the surface of PDMS. The manufacture of the micro-channel needs to manufacture a mask plate, and the mask plate has complex manufacturing process and long time. The technology saves the manufacturing cost of the mask plate, shortens the production period and has better economy. The technology can drive different liquid drops in different paths on the same chip, and only needs to control a plurality of beams of laser.
Drawings
Fig. 1 is a schematic structural diagram of an ultraviolet laser liquid self-driven platform provided by the invention.
Fig. 2 is a schematic diagram of the change in contact angle of a liquid droplet before and after ultraviolet laser irradiation provided by the present invention.
The reference numerals in the above figures illustrate:
1-laser, 2-computer, 3-control module, 4-reflector, 5-laser beam, 6-lens, 7-glass cover, 8-substrate, 9-mobile module/workbench.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer and clearer, the present invention is further described below with reference to the accompanying drawings and examples.
Example 1:
as shown in fig. 1 to fig. 2, the present embodiment discloses an ultraviolet laser liquid self-driven platform, which mainly includes a laser 1, a computer 2, a control module 3, a reflector 4, a lens 6, a glass cover 7, a substrate 8, and a moving module 9. The control module 3 is connected with the laser 1 and controls and adjusts the parameters of the laser emitted by the laser 1. And the computer 2 is respectively connected with the control module 3 and the moving module 9, and respectively controls the laser emitting parameters and sets a liquid self-driving path. The base 8 is mounted at the moving end of the moving module 9 and is fixedly connected with the moving module 9. The glass cover 7 is disposed on the moving module 9, and covers and seals the substrate 8. The glass cover 7 is filled with ozone. The mirror 4 and lens 6 are mounted above the moving module 9, above the base 8.
In a preferred embodiment of the present invention, the substrate 8 is made of polydimethylsiloxane material, and the surface thereof has hydrophobic properties.
As a preferable embodiment of the present invention, the surface of the substrate 8 is a plane, and it is not necessary to scribe a micro channel structure for flowing liquid.
As a preferred embodiment of the present invention, the moving module 9 is a high-precision three-axis moving platform.
As a preferable scheme of the invention, the laser 1 can emit a plurality of laser beams, the number of the reflecting mirror 4 and the lens 6 is adjusted according to the number of the actual laser beams, and the self-driving of a plurality of liquid drops guiding different movement tracks at a time is realized.
The working process and principle of the invention are as follows: the invention takes PDMS as a micro-fluidic platform designed on a substrate 8, and utilizes the characteristic that the directly solidified PDMS has hydrophobicity, and ozone is filled in the micro-fluidic platform while ultraviolet laser is irradiated on one side of the dropping liquid. The hydrophilicity of the laser irradiated area is improved, the contact angle is reduced, and the liquid is pushed to roll by the contact angle difference between the front and the back of the liquid drop. The method can guide the liquid drop to move on the PDMS surface without a channel according to a certain path under the condition of no external driving force by changing the track of the laser on the irradiation area of the PDMS surface. The invention also has the advantages of simple structure, convenient operation and easy implementation.
Example 2:
as shown in fig. 1, the contact angle of the liquid drop on the hydrophobic PDMS surface is relatively large, and when no laser is irradiated on the material surface, the contact angle around the liquid drop is constant, and the liquid drop does not move in a steady state. When the ultraviolet laser is used for irradiating a micro area on one side of the edge of the liquid drop and ozone is filled in the micro area, hydrophilic modification is carried out on the irradiated area, and polar hydrophilic groups such as OH, COOH, CO, COO and the like are formed on the surface of the irradiated area. The PDMS surface irradiated with the laser is changed from hydrophobic to hydrophilic, and the contact angle of the droplet in the irradiated area is also reduced. The droplets spontaneously roll toward the direction of decreasing contact angle.
As shown in fig. 2, the laser 1 generates a laser beam 5, the power, energy, frequency, etc. of which can be adjusted. The laser light is reflected to a lens 6 by a mirror 4 in an optical path system, and then is focused to the surface of PDMS (substrate 8) by the lens 6. PDMS (substrate 8) is covered with a glass cover 7, and ozone is filled into the glass cover 7. The PDMS (substrate 8) is induced by high-energy ultraviolet laser, Si-C chemical bonds on the surface of the PDMS are broken to generate free radicals, and ozone reacts with the free radicals to generate hydrophilic groups such as carboxyl, hydroxyl and the like, so that the hydrophilicity of an irradiation area on the surface of the PDMS (substrate 8) is improved, and the contact angle is reduced. PDMS (substrate 8) is placed on a worktable 9, and the computer 2 and the control module 3 jointly control the accurate movement of the worktable 9. The stage 9 adjusts the distance between the material surface and the laser focus by movement in the Z-axis direction. The computer 2 operates the illumination system, determines the illumination position of the laser on the PDMS surface, moves the workbench 9 according to a certain route, guides the liquid drop to flow on the material surface according to a preset route, and realizes the self-driven directional transportation of the liquid drop on the surface. Meanwhile, the illumination system can emit a plurality of laser beams, and can realize self-driving of a plurality of liquid drops with different motion tracks guided on the surface of PDMS in a single time.
The invention has the advantages that: 1) ozone is filled in the PDMS irradiation area simultaneously through ultraviolet laser irradiation, the hydrophilicity of the PDMS irradiation area is improved, the contact angle is reduced, the gradient difference exists between the contact angle of the liquid drop and the surface of the material, and the liquid drop moves on the surface of the PDMS in a self-driven mode; 2) the shape or the irradiation position of the laser is changed, and the liquid drop is accurately guided to move on the surface of the material according to a certain path through the control workbench 9; 3) through multi-beam laser irradiation, multi-droplet guiding transportation can be realized on the PDMS surface.
In the existing microfluidic technology, a microchannel, a micropump and the like are prepared by taking PDMS as a substrate 8 according to required functions, and then bonding and packaging of a chip are performed. The fluid is driven to move in the channel by an external driving force. In the invention, the contact angle between the liquid drop and the surface of PDMS is reduced by hydrophilic modification through the irradiation of a micro area on one side of the liquid drop by laser, and the liquid drop is driven to move by utilizing the gradient difference of the contact angle of the liquid drop without applying a driving force.
The prior art needs to drive fluid in a closed micro-channel with a single form. In the invention, a microchannel is not required to be prepared, and the PDMS surface is continuously irradiated and modified by controlling the moving track of the laser, so that the liquid drop is guided to move along a certain path.
The existing micro-fluidic chip driving technology drives single fluid, and the efficiency is low. The invention can simultaneously control a plurality of laser beams to drive different liquid drops, thereby greatly improving the working efficiency of the chip.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (5)

1. An ultraviolet laser liquid self-driven platform is characterized by comprising a laser, a computer, a control module, a reflector, a lens, a glass cover, a substrate and a moving module; the control module is connected with the laser and is used for controlling and adjusting the parameters of the laser emitted by the laser; the computer is respectively connected with the control module and the mobile module, and respectively controls the laser emission parameters and sets a liquid self-driving path; the substrate is arranged at the moving end of the moving module and is fixedly connected with the moving module; the glass cover is arranged on the movable module and covers and seals the substrate; ozone is filled in the glass cover; the reflector and the lens are arranged above the moving module and are positioned above the substrate.
2. The UV laser liquid self-propelled platform of claim 1, wherein the substrate is made of polydimethylsiloxane material, and the surface of the substrate has hydrophobic properties.
3. The UV laser liquid self-driven platform as claimed in claim 1, wherein the surface of the substrate is planar without patterning a microchannel structure for liquid flow.
4. The UV laser liquid self-driven platform according to claim 1, wherein the moving module is a high-precision three-axis moving platform.
5. The UV laser liquid self-driven platform as claimed in claim 1, wherein the laser is capable of emitting multiple laser beams to achieve self-driving of multiple droplets for guiding different motion trajectories at a single time.
CN202110136282.8A 2021-02-01 2021-02-01 Ultraviolet laser liquid self-driven platform Pending CN112881742A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110136282.8A CN112881742A (en) 2021-02-01 2021-02-01 Ultraviolet laser liquid self-driven platform

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110136282.8A CN112881742A (en) 2021-02-01 2021-02-01 Ultraviolet laser liquid self-driven platform

Publications (1)

Publication Number Publication Date
CN112881742A true CN112881742A (en) 2021-06-01

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Country Status (1)

Country Link
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