CN112806462A - 一种具有预防宿醉和解酒保肝的组合物及其制备方法 - Google Patents
一种具有预防宿醉和解酒保肝的组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种具有预防宿醉和解酒保肝的组合物及其制备方法,包括显齿蛇葡萄叶速溶粉、大豆肽粉、酵母抽提物、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉、维生素C、山梨糖醇DC、玉米淀粉、硬脂酸镁;本发明通过增强机体代谢能力,加快分解氧化酒精及其代谢产物,减少了乙醇、乙醛对肝细胞膜及线粒体膜损害,保护肝细胞,从而减轻饮酒后的各种长短期不适,如头晕、目眩、恶心呕吐等,很大程度上减少酒精对人体的伤害,本发明提供的解酒制剂不仅具有提高酒量的功效,同时对解酒护肝具有显著作用,本发明可以制备成多种剂型,如片剂、粉剂和饮品。
Description
技术领域
本发明涉及食品技术领域,具体涉及一种具有预防宿醉和解酒保肝的组合物及其制备方法。
背景技术
在交朋结友、商务应酬等社会活动中经常会进行饮酒,过量饮酒对饮用者的身体是有伤害的,酒的主要成分是酒精,化学名称为乙醇。
酒在人体内主要是通过口腔、食管、胃、十二指肠、空肠、回肠、大肠途径进行流通的。在流通的不同部位,酒精的吸收速度各不相同,一般说来,十二指肠>胃>大肠>回肠>口腔。进入血液的乙醛需要再次进入肝脏,经过醛基水解酶的分解,把乙醛变成醋酸,醋酸再分解为二氧化碳和水。肝脏分解酒精的功能是每小时7克,超过了这个量,解酒过程就要延长,这就是“宿醉”。醉酒的真正对象其实就是肝脏。当乙酰水解酶不足时,就会动用肝里面的细胞色素P450酶(CYP450),帮助分解酒精。生活中有些人反复大量饮用过量的酒,过量消耗细胞色素P450酶,CYP450本是肝脏中用来解毒、分解脂肪的,现在却用来解酒,大大浪费了CYP450,使其供不应求,造成脂肪无法分解,毒素无法分解,直接伤害肝脏。
乙醇的消除反应主要通过在肝脏的氧化,且主要受乙醇脱氢酶(ADH)及乙醛脱氢酶(ALDH)催化特性的调控。由胃肠道吸收的乙醇,经血循环进入肝脏,由肝细胞分泌的乙酰水解酶(ADH)把酒精变成乙醛,再进入血液。乙醛是一种毒性极强的物质,过量饮酒(醉酒),使乙酰水解酶不足,就会醉酒。所出现的头晕、头痛、恶心、呕吐,就是乙醛中毒的结果。长期饮酒还会引起肝,胃,病,脾等内脏器官的各种疾病。
因酗酒造成的脂肪肝等慢性肝病患者,免疫功能低下,胆汁分泌异常,常会引起“小肠污染综合征”,出现消化不良,营养不足。肝昏迷时常有大肠杆菌(坏细菌)大量增殖,且易移位到空肠,释放出尿素酶,过多分解尿素产生氨,使血氨升高,加重肝昏迷。如能调整肠道菌群,大量增殖体内有益菌,可以促进肝脏健康,维持肠道菌群平衡,抑制肠道中有害菌的生长,显著地提高免疫功能。
目前,研究和开发出一种解酒效果快、可以有效缓解醉酒后的副作用,且具有保肝护胃、提高人体免疫力的功能的解酒制剂是目前解酒产品中迫切解决的难题。
发明内容
有鉴于此,有必要针对现有技术中存在的问题,提供一种具有预防宿醉和解酒保肝的组合物及其制备方法。
一种具有预防宿醉和解酒保肝的组合物及其制备方法,包括以下成分:显齿蛇葡萄叶速溶粉、大豆肽粉、酵母抽提物、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉、维生素C、以及辅料,其中辅料包括以下成分:山梨糖醇DC、玉米淀粉、硬脂酸镁。
优选地,该种具有预防宿醉和解酒保肝的组合物及其制备方法按重量计包括0.5-10份大豆肽粉、0.5-50份酵母抽提物、0.5-20份显齿蛇葡萄叶速溶粉、0.1-20份小蓟粉、0.5-50份刺梨果粉、0.5-10份蒲公英粉、0.5-50份玉米须粉、0.5-10份辣木叶粉、10-48份山梨糖醇DC、5-40份玉米淀粉、0.5-5份维生素C、0.01-0.4份、0.5-1.5份硬脂酸镁。
优选地,酵母抽提物重量为成分总重的20-40%。
优选地,显齿蛇葡萄叶速溶粉重量为成分总重的20-30%。
优选地,玉米淀粉与玉米须粉的重量比为3:1。
优选地,酵母抽提物的制备过程包括如下步骤:(1)取酵母菌菌浓为106-5×107个/L的发酵液2000-4000g离心20-30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为10-20%的菌悬液,然后反复冻融3-5次后2000-4000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶与甘露聚糖酶进行破壁,反应pH为5.5-6.5,反应温度为35-45℃,反应时间为2-4h,然后在2000-4000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2-2.5kGy,得酵母抽提物。本发明制备的酵母提取物步骤简单,活性物质提取率高,经过60Co-γ射线辐照成功保持各种酶活性,尤其是乙醛脱氢酶和乙醇脱氢酶的活性。
优选地,酵母抽提物的制备过程中葡聚糖酶与菌悬液比为5-10UI/g,甘露聚糖酶与菌悬液比为3-6UI/g。
优选地,大豆肽粉的制备过程包括如下步骤:(1)用纯水将脱脂大豆粉配制成固液重量比2-5%的大豆粉溶液,300-500目过筛;(2)然后用碱液将大豆粉溶液的pH调制8-8.5,按酶/脱脂大豆粉溶液中蛋白质质量比1:(100-200)加入碱性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;然后将pH调至7.0按酶/脱脂大豆粉溶液中蛋白质质量比1:(60-100)加入中性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;(3)然后在室温5000-10000g离心20-30min,收集上清液以及沉淀,其中上清液直接冷冻干燥得上清液冻干粉;(4)步骤(3)收集的沉淀用纯水洗涤2-3次后进行冷冻干燥,然后用纯水配制成固液重量比1-5%的溶液,然后将pH调至2.0按酶/溶液中蛋白质质量比1:(20-50)加入胃蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活,然后将pH调至7.5按酶/溶液中蛋白质质量比1:(20-50)加入胰蛋白酶,反应温度为35-37℃,反应1-2h后,100℃灭活,然后室温下5000-10000g离心10-20min,取上清液,然后进行冷冻干燥,将所得冻干粉与步骤(3)中所得的上清液冻干粉混合得大豆肽粉。
一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于包括以下步骤:
(1)将山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40-50目筛2-3次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%以下,过20-30目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
本发明与现有技术相比,具有以下优点:
本发明制备的一种具有预防宿醉和解酒保肝的组合物,加快酒精的代谢,能快速降低血液中的酒精浓度,从而减轻饮酒后的各种长短期不适,如头晕、目眩、恶心呕吐等,很大程度上减少酒精对人体的伤害,本发明提供的解酒制剂具有醒酒、养胃、护肝的作用,同时还可以有效缓解宿醉、缩短醒酒时间的优点,同时本发明制备的一种具有预防宿醉和解酒保肝的组合物口味香甜,风味佳,不如传统保健品或药品味苦、味涩,用户适应性良好。本发明的原料种类少工艺简单,可制备成食品和保健食品。
酒精代谢过程较为复杂,饮酒时摄入的酒精,首先会经口腔进入食道,再由食道进入胃液和肠液。酒精先通过乙醇脱氢酶/乙醇氧化酶/过氧化氢酶将乙醇氧化为乙醛,然后经过乙醛脱氢酶氧化层乙酸。乙酸随后进入三羧酸循环(TCA),彻底氧化分解为二氧化碳和水,经尿液排出体外,从而解除乙醛的毒副作用。酵母提取物中的活性成分能激活乙醛脱氢酶的活性,加快乙醛分解代谢;并且可与酒精的代谢产物乙醛结合,使其失活、加速排出体外,减少了乙醛对肝细胞膜及线粒体膜损害,保护肝细胞。显齿蛇葡萄叶速溶粉中的主要成分是二氢杨梅素,二氢杨梅素是较为特殊的一种黄酮类化合物,除具有黄酮类化合物的一般特性外,还具有解除醇中毒、预防酒精肝、脂肪肝、抑制肝细胞恶化、降低肝癌的发病率等作用,是保肝护肝,解酒醒酒的良品。蒲公英粉具有肝脏滋养的作用。刺梨果粉可以促进肠百胃健康,能够健脾消食,帮助缓解消化不良。小蓟粉对于由四氯化碳、半乳糖胺,醇类和其他肝毒素造成的肝损害具有保护作用。玉米须粉具有利尿,加速***的作用。辣木叶粉具有改善肠胃功能,有利于消化食物,加快代谢,对胃起到很好保护作用,特别是宿醉。
大豆肽粉是相对分子质量在5000以下肽的粉末状物质,含有多种生物活性肽,具有多种生理活性,包括抗氧化、降血压、降低胆固醇、降血脂、抗疲劳、增强免疫等。作为一种新型多功能营养配料,大豆肽粉可广泛地用于保健食品、婴幼儿食品、运动食品、发酵制品及临床营养制剂等。国内外的大豆肽粉的生产大多采用酶解,取上清的方式,但在大豆蛋白水解过程中,不可避免地会发生肽的聚集,不溶性多肽聚集体的丢弃降低了大豆肽的的生产效率,并且大多不溶性聚集体多肽仍具有很高的蛋白活性,本发明对水解过程中的不溶性物质进行了再利用,大大提高了大豆的利用率,提高了大豆粉的活性。目前国内外关于大豆多肽用于解酒的报导较少,其机理也尚未明确,本发明将大豆肽用于解酒的制作解酒压片糖果,得到了良好的效果。
具体实施方式
下面结合实施例对本发明做进一步的解释说明。
大豆肽粉的制备如下:(1)用纯水将脱脂大豆粉配制成固液重量比4%的大豆粉溶液,400目过筛;(2)然后用碱液将大豆粉溶液的pH调制8.5,按酶/脱脂大豆粉溶液中蛋白质质量比1:150加入碱性蛋白酶,反应温度为55℃,反应2h后,100℃灭活;然后将pH调至7.0按酶/脱脂大豆粉溶液中蛋白质质量比1:70加入中性蛋白酶,反应温度为55℃,反应2h后,100℃灭活;(3)然后在室温6000g离心30min,收集上清液以及沉淀,其中上清液直接冷冻干燥得上清液冻干粉;(4)步骤(3)收集的沉淀用纯水洗涤3次后进行冷冻干燥,然后用纯水配制成固液重量比3%的溶液,然后将pH调至2.0按酶/溶液中蛋白质质量比1:40加入胃蛋白酶,反应温度为55℃,反应2h后,100℃灭活,然后将pH调至7.5按酶/溶液中蛋白质质量比1:40加入胰蛋白酶,反应温度为37℃,反应2h后,100℃灭活,然后室温下10000g离心10min,取上清液,然后进行冷冻干燥,将所得冻干粉与步骤(3)中所得的上清液冻干粉混合得大豆肽粉。
实施例1
本发明的一种具有预防宿醉和解酒保肝的组合物及其制备方法,每1000片总量配方见下表1。
表1一种具有预防宿醉和解酒保肝的组合物
一种具有预防宿醉和解酒保肝的组合物及其制备方法的制备:
(1)将物料山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40目筛3次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%,过20目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
其中,酵母抽提物的制备:(1)取酵母菌菌浓为107个/L的发酵液2000g离心30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为20%的菌悬液,然后反复冻融3次后2000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶(5UI/g)与甘露聚糖酶(3UI/g)进行破壁,反应pH为6,反应温度为40℃,反应时间为4h,然后在2000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2.5kGy,得酵母抽提物。
实施例2
本发明的一种具有预防宿醉和解酒保肝的组合物及其制备方法,每1000片总量配方配方见下表2。
表2一种具有预防宿醉和解酒保肝的组合物
一种具有预防宿醉和解酒保肝的组合物及其制备方法的制备:
(1)将物料山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过50目筛2次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%,过20目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
其中,酵母抽提物的制备:(1)取酵母菌菌浓为107个/L的发酵液4000g离心30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为10%的菌悬液,然后反复冻融5次后2000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶(10UI/g)与甘露聚糖酶(6UI/g)进行破壁,反应pH为6,反应温度为40℃,反应时间为4h,然后在4000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2kGy,得酵母抽提物。
实施例3
本发明的一种具有预防宿醉和解酒保肝的组合物及其制备方法,每1000片总量配方配方见下表3。
表3一种具有预防宿醉和解酒保肝的组合物
一种具有预防宿醉和解酒保肝的组合物及其制备方法的制备:
(1)将物料山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40目筛2次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%,过20目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
其中,酵母抽提物的制备:(1)取酵母菌菌浓为107个/L的发酵液4000g离心30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为10%的菌悬液,然后反复冻融5次后2000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶(10UI/g)与甘露聚糖酶(6UI/g)进行破壁,反应pH为6,反应温度为40℃,反应时间为4h,然后在4000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2kGy,得酵母抽提物。
实施例4
本发明的一种具有预防宿醉和解酒保肝的组合物及其制备方法,每1000片总量配方配方见下表4。
表4一种具有预防宿醉和解酒保肝的组合物
一种具有预防宿醉和解酒保肝的组合物及其制备方法的制备:
(1)将物料山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40目筛2次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%,过20目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
实施例5
本发明的一种具有预防宿醉和解酒保肝的组合物及其制备方法,每1000片总量配方配方见下表5。
表5一种具有预防宿醉和解酒保肝的组合物
一种具有预防宿醉和解酒保肝的组合物及其制备方法的制备:
(1)将物料山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40目筛2次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%,过20目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
其中,酵母抽提物的制备:(1)取酵母菌菌浓为107个/L的发酵液4000g离心30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为10%的菌悬液,然后反复冻融5次后2000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶(10UI/g)与甘露聚糖酶(6UI/g)进行破壁,反应pH为6,反应温度为40℃,反应时间为4h,然后在4000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2kGy,得酵母抽提物。
测试例
1、解酒效果评价
选择正常小鼠160只,分为8组,每组20只,其中7组分别灌胃以20mg/kg体重剂量的实施例1-5制备的一种具有预防宿醉和解酒保肝的组合物,和对照组1-2制备的一种具有预防宿醉和解酒保肝的组合物,空白对照组则不灌胃,30min后,给小鼠以12mL/kg体重灌胃白酒,然后立即将小鼠放在垂直的金属网上,观察小鼠活动情况并记录小鼠掉落下金属网为止的攀附时间。随后将小鼠分别单独翻转放置在各个铺有滤纸的平板上,观察记录其醉酒时间,即小鼠翻正反射消失到翻正反射恢复的时间,并收集滤纸重量,计算小鼠排尿量。其中,在给与白酒后0.5h、3h,每组取5只小鼠处死,取肝测定乙醇和乙醛浓度。具体实验数据见表7,数据均为均值。
对照例1为采用实施例5的制备方案,但是其中大豆肽粉为某品牌产品。
对照例2采用实施例5的制备方案,但其中大豆肽粉的制备过程为(1)用纯水将脱脂大豆粉配制成固液重量比2-5%的大豆粉溶液,300-500目过筛;(2)然后用碱液将大豆粉溶液的pH调制8-8.5,按酶/脱脂大豆粉溶液中蛋白质质量比1:(100-200)加入碱性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;然后将pH调至7.0按酶/脱脂大豆粉溶液中蛋白质质量比1:(60-100)加入中性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;(3)然后在室温5000-10000g离心20-30min,收集上清液以及沉淀,其中上清液直接冷冻干燥得上清液冻干粉即为大豆肽粉。
表6解酒效果评价
根据表6可以看出,本发明制备的一种具有预防宿醉和解酒保肝的组合物可以有效降解乙醇,利于排尿,加速解酒。将实施例1与实施例2比较发现,适当增加酵母抽提物含量至10%,同时增加显齿蛇葡萄叶速溶粉的含量,两者合理配比具有协同作用有利于本发明的醒酒效果,将实施例2与实施例3比较,可以看出,当玉米淀粉与玉米须粉的比为3:1时,更利于排尿从而加速醒酒。将实施例5与实施例4比较可以发现,如果酵母提取物量过多,即使显齿蛇葡萄叶速溶粉含量增加,醒酒效果也会有所下降。实施例3效果最佳,其中显齿蛇葡萄叶速溶粉与酵母合理配比,玉米淀粉与玉米须粉合理配比使得醒酒效果突出。将实施例5与对照组1相比,可以看出本发明制备的大豆肽粉效果更佳。将实施例5与对照组2对比,可以看出,水解过程中不溶物中的确还有大量对于解酒有利的成分,对其进行再利用可以有效提高大豆肽的解酒作用。经上述实验可以看出,本发明制备的一种具有预防宿醉和解酒保肝的组合物是经过多次试验得出的,并不是简单的配方的堆砌,本发明使用的各种原料以及原料含量都是通过反复验证得出,具有显著的解酒功效。
2、保肝护肝效果评价
取小鼠50只,分为5组,分别为空白组、对照组1-3和实验组,实验组和对照组1-2小鼠每天灌喂实施例5以及测试例1中对照例1-2制备的一种具有预防宿醉和解酒保肝的组合物,给药30min后,灌喂白酒(12mL/kg体重),对照组3小鼠每天仅灌胃白酒,空白组以蒸馏水代替白酒,每天1次,连续7天,7天后检测小鼠肝组织丙氨酸氨基转移酶(ALT)以及天冬氨酸氨基转移酶(AST)含量。具体实验数据如下表7。
表7小鼠肝组织ALT、AST水平
组别 | ALT(U/L) | AST(U/L) |
对照组1 | 76.55 | 37.08 |
对照组2 | 74.61 | 40.38 |
对照组3 | 107.44 | 56.71 |
实验组 | 70.53 | 32.84 |
空白组 | 67.44 | 31.68 |
根据表7可以看出,服用本发明的小鼠体内ALT与AST指标没有明显上升,本发明制备的大豆肽粉在保肝护肝方面有的效果明显。说明在饮酒前服用本发明的一种具有预防宿醉和解酒保肝的组合物,可以有效保肝护肝,使ALT、AST保持较为正常水平。
3、宿醉效果评价
招募志愿者150名,随机分为5组,每组各30名,实验组饮酒前30分钟服用两片实施例5制备的一种具有预防宿醉和解酒保肝的组合物,然后饮用白酒300mL。对志愿者进行电话寻访,结果如表8。
表8宿醉效果评价结果
有效人数 | 头晕、头痛 | 乏力 | 呕吐 | 胃部灼烧感 |
第一组 | 30 | 27 | 28 | 30 |
第二组 | 30 | 25 | 30 | 30 |
第三组 | 29 | 29 | 29 | 29 |
第四组 | 28 | 27 | 26 | 27 |
第五组 | 30 | 25 | 26 | 25 |
平均值 | 29.2 | 26.6 | 27.8 | 28.2 |
从表8可以看出,以实施例5做的实验结果来看,对乏力的改善有效率88.67%,对呕吐的有效率为92.67%,对改善参与人员胃部灼烧感的有效率为94%,对头晕、头痛的有效缓解率高达98%,从实验结果来看本发明对酒后宿醉具有显著的功效。
本发明提供的一种具有预防宿醉和解酒保肝的组合物及其制备方法采用严格的企业标准制备,相关企业标准已在江苏省卫健委备案,备案号为322949S-2020。
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。
Claims (8)
1.一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于包括以下成分:显齿蛇葡萄叶速溶粉(二氢杨梅素含量≥52%)、大豆肽粉、酵母抽提物、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉、维生素C、以及辅料,其中辅料包括以下成分:山梨糖醇DC、玉米淀粉、硬脂酸镁。
2.根据权利要求1所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于按重量计包括0.5-10份大豆肽粉、0.5-50份酵母抽提物、0.5-20份显齿蛇葡萄叶速溶粉、0.1-20份小蓟粉、0.5-50份刺梨果粉、0.5-10份蒲公英粉、0.5-50份玉米须粉、0.5-10份辣木叶粉、10-48份山梨糖醇DC、5-40份玉米淀粉、0.5-5份维生素C、0.01-0.4份0.5-1.5份硬脂酸镁。
3.根据权利要求1所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于所述酵母抽提物重量为成分总重的20-40%。
4.根据权利要求1所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于所述玉米淀粉与所述玉米须粉的重量比为3:1。
5.根据权利要求1所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于所述酵母抽提物的制备过程包括如下步骤:(1)取酵母菌菌浓为106-5×107个/L的发酵液2000-4000g离心20-30min,取细胞沉淀;(2)用纯水重悬细胞沉淀,配制成为固液重量比为10-20%的菌悬液,然后反复冻融3-5次后2000-4000g离心10min,取上清液;(3)将步骤(2)所得上清液中加入葡聚糖酶与甘露聚糖酶进行破壁,反应pH为5.5-6.5,反应温度为35-45℃,反应时间为2-4h,然后在2000-4000g离心10min,取酶解上清液;(4)将步骤(3)制备的酶解上清液喷雾干燥成粉,然后经60Co-γ射线辐照灭菌,辐照剂量为2-2.5kGy,得酵母抽提物。
6.根据权利要求5所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于所述酵母抽提物的制备过程中葡聚糖酶与菌悬液比为5-10UI/g,甘露聚糖酶与菌悬液比为3-6UI/g。
7.根据权利要求1所述的一种具有预防宿醉和解酒保肝的组合物及其制备方法,其特征在于所述大豆肽粉的制备过程包括如下步骤:(1)用纯水将脱脂大豆粉配制成固液重量比2-5%的大豆粉溶液,300-500目过筛;(2)然后用碱液将大豆粉溶液的pH调制8-8.5,按酶/脱脂大豆粉溶液中蛋白质质量比1:(100-200)加入碱性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;然后将pH调至7.0按酶/脱脂大豆粉溶液中蛋白质质量比1:(60-100)加入中性蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活;(3)然后在室温5000-10000g离心20-30min,收集上清液以及沉淀,其中上清液直接冷冻干燥得上清液冻干粉;(4)步骤(3)收集的沉淀用纯水洗涤2-3次后进行冷冻干燥,然后用纯水配制成固液重量比1-5%的溶液,然后将pH调至2.0按酶/溶液中蛋白质质量比1:(20-50)加入胃蛋白酶,反应温度为50-60℃,反应1-2h后,100℃灭活,然后将pH调至7.5按酶/溶液中蛋白质质量比1:(20-50)加入胰蛋白酶,反应温度为35-37℃,反应1-2h后,100℃灭活,然后室温下5000-10000g离心10-20min,取上清液,然后进行冷冻干燥,将所得冻干粉与步骤(3)中所得的上清液冻干粉混合得大豆肽粉。
8.一种具有预防宿醉和解酒保肝的组合物及其制备方法,用于制备权利要求1-7任意一项所述的具有预防宿醉和解酒保肝的组合物,其特征在于包括以下步骤:
(1)将山梨糖醇DC、玉米淀粉、酵母抽提物、显齿蛇葡萄叶速溶粉、小蓟粉、刺梨果粉、蒲公英粉、玉米须粉、辣木叶粉准确称量,过40-50目筛2-3次,得初步混合物;
(2)采用75%酒精制粒,烘干至含水量为5%以下,过20-30目筛网,取整粒;
(3)准确称量大豆肽粉、维生素C、硬脂酸镁,加入步骤(2)中,搅拌混匀3-5min,压片。
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