CN112755164A - 一种强筋壮骨的中药组合物、其制剂及应用 - Google Patents
一种强筋壮骨的中药组合物、其制剂及应用 Download PDFInfo
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- CN112755164A CN112755164A CN202110168781.5A CN202110168781A CN112755164A CN 112755164 A CN112755164 A CN 112755164A CN 202110168781 A CN202110168781 A CN 202110168781A CN 112755164 A CN112755164 A CN 112755164A
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Abstract
本发明涉及一种强筋壮骨的中药组合物、其制剂及应用,所述强筋壮骨的中药组合物,通过采用独活、桑寄生、云苓等60味中药为原料并进行适合的重量配比,使得各种原料相互配合,彼此增益,从扶正固本、温经散寒、祛风胜湿、舒筋活络、止痛除痹等多个方面发挥作用,用于治疗风寒湿痹、筋骨疼痛、肢体麻木、关节屈伸不利、肩颈病、腰腿痛、骨质增生、腰椎间盆突出、诸症劳损等中医痹症效果显著,具有见效快,安全无毒副作用、成本低廉、易于工业化生产的特点。
Description
技术领域
本发明属于中药技术领域,具体涉及一种强筋壮骨的中药组合物、其制剂及应用。
背景技术
风寒湿三气痹着日久,邪气留连,痛久入深,或着于筋脉,或着于肌骨,荣卫凝涩不通,气血运行不畅,久而久之,肝肾失养,气血失荣,而成肝肾不足,气血两虚之证。
筋骨与肝肾脾关系最为密切,肝主筋,主运动,主藏血。肾主骨,主生髓为后天之本。脾主肌肉主运化,为后天之本,而人体两本最易透支又肝肾同源。肝肾脾的亏虚可表现出衰老状态,表现为筋的运动不灵活,因此肝血不足,血不养筋,即可出现手足拘挛,肢体麻木,屈伸不利等症,如颈椎病、腰椎间盘突出症等病的发生。骨是支持人体的支架,骨的健康依赖肾气的濡养和脾气荣华,肾精脾气肝血不足,则骨髓空虚,筋骨肌萎无力,即可出现腿足痿软不能行动,腰酸背痛活动不便等症。肝肾脾亏虚主要发生在久病之后或年老体弱未老先衰的患者,临床上对肝肾亏虚的筋伤患者,要注意调养肝肾脾。通过调养肝肾脾可以防止诸如颈肩腰腿痛和骨质疏松症等类疾病,正所谓“正气存内,邪不可干”。
现有的调理肝肾脾,进而达到强筋壮骨的中药较多,但治疗效果并不理想。
发明内容
本发明的目的在于提供一种强筋壮骨的中药组合物,所述中药组合物能够补益肝肾,调理气血以温养脏腑、培补正气,进而通利血脉、养筋骨,起到营养五脏强筋壮骨的作用。
为实现本发明的上述目的,本发明采用以下技术方案:
一种强筋壮骨的中药组合物,包括如下重量份的原料组分:
独活270-330重量份、桑寄生135-165重量份、云苓90-110重量份、川芎135-165重量份、肉桂36-44重量份、当归180-220重量份、白芍108-132重量份、熟地180-220重量份、人参180-220重量份、鹿茸180-220重量份、炙甘草135-165重量份、秦艽108-132重量份、防风135-165重量份、牛膝135-165重量份、细辛810-990重量份、杜仲144-176重量份、黄芪450-550重量份、麻黄45-55重量份、干姜450-550重量份、乳香去油135-165重量份、没药去油135-165重量份、苍术162-198重量份、白芷90-110重量份、天麻90-110重量份、木香81-99重量份、砂仁108-132重量份、石菖蒲135-165重量份、制吴茱萸81-99重量份、地龙135-165重量份、制元胡270-330重量份、杞子180-220重量份、补骨脂180-220重量份、淫羊藿108-132重量份、桂枝135-165重量份、制乌头900-1100重量份、海桐皮900-1100重量份、泽泻108-132重量份、淮山108-132重量份、山茱萸144-176重量份、夏天无270-330重量份、制南星144-176重量份、车前子144-176重量份、羌活252-308重量份、全虫720-880重量份、鸡血藤900-1100重量份、靳蛇900-1100重量份、巴戟天162-198重量份、菟丝子180-220重量份、三棱90-110重量份、莪术90-110重量份、白术81-99重量份、川木瓜162-198重量份、黄柏90-110重量份、威灵仙180-220重量份、防己180-220重量份、千年健162-198重量份、狗脊162-198重量份、陈皮54-66重量份、生薏米144-176重量份、大枣108-132重量份。
优选的,所述的强筋壮骨的中药组合物包括如下重量份的原料组分:
独活300重量份、桑寄生150重量份、云苓100重量份、川芎150重量份、肉桂40重量份、当归200重量份、白芍120重量份、熟地200重量份、人参200重量份、鹿茸200重量份、炙甘草150重量份、秦艽120重量份、防风150重量份、牛膝150重量份、细辛900重量份、杜仲160重量份、黄芪500重量份、麻黄50重量份、干姜500重量份、乳香去油150重量份、没药去油150重量份、苍术180重量份、白芷100重量份、天麻100重量份、木香90重量份、砂仁120重量份、石菖蒲150重量份、制吴茱萸90重量份、地龙150重量份、制元胡300重量份、杞子200重量份、补骨脂200重量份、淫羊藿120重量份、桂枝150重量份、制乌头1000重量份、海桐皮1000重量份、泽泻120重量份、淮山120重量份、山茱萸160重量份、夏天无300重量份、制南星160重量份、车前子160重量份、羌活280重量份、全虫800重量份、鸡血藤1000重量份、靳蛇1000重量份、巴戟天180重量份、菟丝子200重量份、三棱100重量份、莪术100重量份、白术90重量份、川木瓜180重量份、黄柏100重量份、威灵仙200重量份、防己200重量份、千年健180重量份、狗脊180重量份、陈皮60重量份、生薏米160重量份、大枣120重量份。
本发明强筋壮骨的中药组合物,由独活、桑寄生、云苓等60味中药组成,方中选用人参、鹿茸、巴戟天、补骨脂、淫羊藿补肾阳、强筋骨,辅以黄芪益卫固表,补气升阳,牛膝、杜仲、菟丝子、山茱萸、杞子补肝肾,以加强补肾阳、强筋骨的作用;配以炙甘草、陈皮、生薏米、淮山、白术补脾和胃,益气复脉;肉桂、细辛、麻黄、干姜、白芷、制吴茱萸、桂枝散寒止痛,温通经脉,川芎、夏天无、三棱、莪术、木香、制元胡活血行气,当归、乳香、没药、鸡血藤活血止痛以佐助温经散寒之功效;又用独活、桑寄生、云苓、秦艽、防风、苍术、制乌头、海桐皮、制南星、羌活、靳蛇、威灵仙、防己、千年健、狗脊、砂仁、川木瓜、石菖蒲、天麻祛风除湿,通痹止痛、舒筋通络;以及白芍、熟地、大枣养血益气;泽泻、车前子、黄柏利水渗湿、清热除燥;最后以地龙、全虫走窜之性,引导诸药透皮达经,直达病灶。诸药合用,共奏扶正固本、温经散寒、祛风胜湿、舒筋活络、止痛除痹、强筋壮骨之功。
本发明为治疗风寒湿痹、筋骨疼痛、肢体麻木、关节屈伸不利、肩颈病、腰腿痛、骨质增生、腰椎间盆突出、诸症劳损等中医痹症而研发的内服中药。适用于气血两虚、风寒湿痹、筋骨疼痛、透支劳损、肢体麻木、陈旧性伤痛、肩颈病、腰腿痛、骨质增生、腰椎间盆突出、坐骨神经痛以及肝肾精血不足、筋骨无力、脾胃虚寒、脘腹胀痛、食欲不振、气短神疲、夜尿频多、视力衰退、耳鸣失聪、早生白发、未老先衰、免疫力下降、妇女宫寒、白带多等。
根据本发明所述的强筋壮骨的中药组合物,可按照常规的制剂学工艺制备成为药学上可接受的任何内服药物剂型,优选为酒剂、汤剂、丸剂、膏剂中的任意一种,更优选为酒剂,酒剂的制备方法包括如下步骤:
(1)取各中药组分,分别经净制、干燥后粉碎,优选的,粉碎至粒径为60-100目,得到各中药细粉;将所述各中药细粉混合均匀,得到混合药粉;
(2)向混合药粉中加入白酒或米酒,密封浸泡,之后过滤去渣,得到中药酒液;优选的,所述混合药粉和白酒/米酒之间的质量比为1:3.5-4.5,所述白酒为酒精度不低于42°的纯粮食酒,所述米酒为酒精度为40°的米酒;进一步优选的,先向混合药粉中加入60%的白酒或米酒,密封浸泡80-100天,优选为90天,过滤,然后向过滤之后的药渣中加入剩余的白酒或米酒,密封浸泡50-70天,优选为60天,过滤去渣,合并两次滤液,得到中药酒液;
(3)向中药酒液中加入冰糖,优选的,所述中药酒液的体积与冰糖的质量之比为500mL:30-40g,搅拌使溶解均匀,即得。
本发明的有益效果为:
本发明所述强筋壮骨的中药组合物,通过采用独活、桑寄生、云苓等60味中药为原料并进行适合的重量配比,使得各种原料相互配合,彼此增益,从扶正固本、温经散寒、祛风胜湿、舒筋活络、止痛除痹等多个方面发挥作用,用于治疗风寒湿痹、筋骨疼痛、肢体麻木、关节屈伸不利、肩颈病、腰腿痛、骨质增生、腰椎间盆突出、诸症劳损等中医痹症效果显著,具有见效快,安全无毒副作用、成本低廉、易于工业化生产的特点。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明的一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1
本实施例提供一种强身壮骨酒,由如下原料制备而成:
独活300g、桑寄生150g、云苓100g、川芎150g、肉桂40g、当归200g、白芍120g、熟地200g、人参200g、鹿茸200g、炙甘草150g、秦艽120g、防风150g、牛膝150g、细辛900g、杜仲160g、黄芪500g、麻黄50g、干姜500g、乳香去油150g、没药去油150g、苍术180g、白芷100g、天麻100g、木香90g、砂仁120g、石菖蒲150g、制吴茱萸90g、地龙150g、制元胡300g、杞子200g、补骨脂200g、淫羊藿120g、桂枝150g、制乌头1000g、海桐皮1000g、泽泻120g、淮山120g、山茱萸160g、夏天无300g、制南星160g、车前子160g、羌活280g、全虫800g、鸡血藤1000g、靳蛇1000g、巴戟天180g、菟丝子200g、三棱100g、莪术100g、白术90g、川木瓜180g、黄柏100g、威灵仙200g、防己200g、千年健180g、狗脊180g、陈皮60g、生薏米160g、大枣120g。
本实施例强身壮骨酒的制备方法包括如下步骤:
(1)取各中药组分,分别经净制、干燥后粉碎至粒径为80目,得到各中药细粉;将所述各中药细粉混合均匀,得到混合药粉;
(2)将混合药粉置于无纺布中药袋中,然后加入72斤42°白酒,密封浸泡90天,过滤,然后向过滤之后的药渣中加入48斤42°白酒,密封浸泡60天,过滤去渣,合并两次滤液,得到中药酒液;
(3)向中药酒液中加入冰糖(中药酒液:冰糖=500mL:35g),搅拌使溶解均匀,即得所述强身壮骨酒。
实施例2
本实施例提供一种强身壮骨酒,由如下原料制备而成:
独活270g、桑寄生165g、云苓90g、川芎165g、肉桂36g、当归220g、白芍108g、熟地220g、人参180g、鹿茸220g、炙甘草135g、秦艽132g、防风135g、牛膝165g、细辛810g、杜仲176g、黄芪450g、麻黄55g、干姜450g、乳香去油165g、没药去油135g、苍术198g、白芷90g、天麻110g、木香81g、砂仁132g、石菖蒲135g、制吴茱萸99g、地龙135g、制元胡330g、杞子180g、补骨脂220g、淫羊藿108g、桂枝165g、制乌头900g、海桐皮1100g、泽泻108g、淮山132g、山茱萸144g、夏天无330g、制南星144g、车前子176g、羌活252g、全虫880g、鸡血藤900g、靳蛇1100g、巴戟天162g、菟丝子220g、三棱90g、莪术110g、白术81g、川木瓜198g、黄柏90g、威灵仙220g、防己180g、千年健198g、狗脊162g、陈皮66g、生薏米144g、大枣132g。
本实施例强身壮骨酒的制备方法包括如下步骤:
(1)取各中药组分,分别经净制、干燥后粉碎至粒径为60目,得到各中药细粉;将所述各中药细粉混合均匀,得到混合药粉;
(2)将混合药粉置于无纺布中药袋中,然后加入62斤42°白酒,密封浸泡80天,过滤,然后向过滤之后的药渣中加入41斤42°白酒,密封浸泡70天,过滤去渣,合并两次滤液,得到中药酒液;
(3)向中药酒液中加入冰糖(中药酒液:冰糖=500mL:30g),搅拌使溶解均匀,即得所述强身壮骨酒。
实施例3
本实施例提供一种强身壮骨酒,由如下原料制备而成:
独活330g、桑寄生135g、云苓110g、川芎135g、肉桂44g、当归180g、白芍132g、熟地180g、人参220g、鹿茸180g、炙甘草165g、秦艽108g、防风165g、牛膝135g、细辛990g、杜仲144g、黄芪550g、麻黄45g、干姜550g、乳香去油135g、没药去油165g、苍术162g、白芷110g、天麻90g、木香99g、砂仁108g、石菖蒲165g、制吴茱萸81g、地龙165g、制元胡270g、杞子220g、补骨脂180g、淫羊藿132g、桂枝135g、制乌头1100g、海桐皮900g、泽泻132g、淮山108g、山茱萸176g、夏天无270g、制南星176g、车前子144g、羌活308g、全虫720g、鸡血藤1100g、靳蛇900g、巴戟天198g、菟丝子180g、三棱110g、莪术90g、白术99g、川木瓜162g、黄柏110g、威灵仙180g、防己220g、千年健162g、狗脊198g、陈皮54g、生薏米176g、大枣108g。
本实施例强身壮骨酒的制备方法包括如下步骤:
(1)取各中药组分,分别经净制、干燥后粉碎至粒径为100目,得到各中药细粉;将所述各中药细粉混合均匀,得到混合药粉;
(2)将混合药粉置于无纺布中药袋中,然后加入80斤40°米酒,密封浸泡100天,过滤,然后向过滤之后的药渣中加入53斤40°米酒,密封浸泡50天,过滤去渣,合并两次滤液,得到中药酒液;
(3)向中药酒液中加入冰糖(中药酒液:冰糖=500mL:40g),搅拌使溶解均匀,即得所述强身壮骨酒。
对比例1
与实施例1的区别仅在于黄芪和川芎的用量不同,本对比例中黄芪为400g,川芎为250g。
对比例2
与实施例1的区别仅在于去掉生薏米。
本发明对大鼠佐剂性关节炎的影响试验
取SD大鼠50只,体重180-220g,雄性,随机分为模型组、阳性对照组、实施例1以及对比例1、2药酒组共5组,每组10只。各组大鼠右后足趾皮内注射Freand's完全佐剂0.1ml/只致炎,之后立即灌胃给药,模型组给予生理盐水,阳性对照组给予醋酸***20mg/kg,实施例1以及对比例1、2组给药剂量为0.3mL/kg,各组每日给药1次,连续给药21天,第12天起每3天测量大鼠右后足的体积,计算足趾肿胀度,足趾肿胀度=致炎后的足趾容积-致炎前足趾容积。结果见表1。
表1各组对大鼠佐剂性关节炎的影响
与模型组比,*p<0.05,与阳性对照组比,#p<0.05。
结果表明,与模型组相比,各组足趾肿胀度随着时间的延长均有显著降低,与阳性对照组比,实施例1组各时间点的足趾肿胀度均有明显差异,而对比例1组、对比例2组无明显差异,说明本发明强身壮骨酒对大鼠佐剂性关节炎的继发性病变有明显的抑制作用,且实施例1明显优于对比例1和对比例2,提示本发明强身壮骨酒有较好的抗炎作用,在风寒湿痹等各种原因引起的关节炎性病变的治疗方面有较好的应用前景。
本发明治疗膝骨关节炎的总体治疗效果研究
1、一般资料:参考1995年美国风湿病协会修订的“膝骨关节炎”诊断标准,选取符合标准的膝骨关节炎患者92例,其中,治疗组60例:男28例,女32例,年龄40-64岁,病程3-10年;对照组32例:男15例,女17例,年龄42-68岁,病程2-10年。各组在性别、年龄分别、病程方面均无显著性差异,具有可比性。
2、治疗方法:治疗组给予口服实施例1强身壮骨酒,10mL/次,2次/日;对照组给予口服风湿寒痛片,6片/次,2次/日,各组连续服用3个月。
3、疗效标准:痊愈:临床症状完全消失,功能活动恢复正常;显效:关节疼痛明显减轻,关节功能基本恢复;有效:关节疼痛减轻,关节功能仍受限;无效:与治疗前相比无明显变化。
4、治疗结果:见表2。
表2各组总体治疗效果对比
结果表明,治疗组、对照组总有效率分别为95.00%、81.25%,可见本发明实施例1强身壮骨酒具有较好的治疗膝骨关节炎的效果,且治疗效果较现有技术具有明显的优越性。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种强筋壮骨的中药组合物,其特征在于,包括如下重量份的原料组分:
独活270-330重量份、桑寄生135-165重量份、云苓90-110重量份、川芎135-165重量份、肉桂36-44重量份、当归180-220重量份、白芍108-132重量份、熟地180-220重量份、人参180-220重量份、鹿茸180-220重量份、炙甘草135-165重量份、秦艽108-132重量份、防风135-165重量份、牛膝135-165重量份、细辛810-990重量份、杜仲144-176重量份、黄芪450-550重量份、麻黄45-55重量份、干姜450-550重量份、乳香去油135-165重量份、没药去油135-165重量份、苍术162-198重量份、白芷90-110重量份、天麻90-110重量份、木香81-99重量份、砂仁108-132重量份、石菖蒲135-165重量份、制吴茱萸81-99重量份、地龙135-165重量份、制元胡270-330重量份、杞子180-220重量份、补骨脂180-220重量份、淫羊藿108-132重量份、桂枝135-165重量份、制乌头900-1100重量份、海桐皮900-1100重量份、泽泻108-132重量份、淮山108-132重量份、山茱萸144-176重量份、夏天无270-330重量份、制南星144-176重量份、车前子144-176重量份、羌活252-308重量份、全虫720-880重量份、鸡血藤900-1100重量份、靳蛇900-1100重量份、巴戟天162-198重量份、菟丝子180-220重量份、三棱90-110重量份、莪术90-110重量份、白术81-99重量份、川木瓜162-198重量份、黄柏90-110重量份、威灵仙180-220重量份、防己180-220重量份、千年健162-198重量份、狗脊162-198重量份、陈皮54-66重量份、生薏米144-176重量份、大枣108-132重量份。
2.根据权利要求1所述的强筋壮骨的中药组合物,其特征在于,包括如下重量份的原料组分:
独活300重量份、桑寄生150重量份、云苓100重量份、川芎150重量份、肉桂40重量份、当归200重量份、白芍120重量份、熟地200重量份、人参200重量份、鹿茸200重量份、炙甘草150重量份、秦艽120重量份、防风150重量份、牛膝150重量份、细辛900重量份、杜仲160重量份、黄芪500重量份、麻黄50重量份、干姜500重量份、乳香去油150重量份、没药去油150重量份、苍术180重量份、白芷100重量份、天麻100重量份、木香90重量份、砂仁120重量份、石菖蒲150重量份、制吴茱萸90重量份、地龙150重量份、制元胡300重量份、杞子200重量份、补骨脂200重量份、淫羊藿120重量份、桂枝150重量份、制乌头1000重量份、海桐皮1000重量份、泽泻120重量份、淮山120重量份、山茱萸160重量份、夏天无300重量份、制南星160重量份、车前子160重量份、羌活280重量份、全虫800重量份、鸡血藤1000重量份、靳蛇1000重量份、巴戟天180重量份、菟丝子200重量份、三棱100重量份、莪术100重量份、白术90重量份、川木瓜180重量份、黄柏100重量份、威灵仙200重量份、防己200重量份、千年健180重量份、狗脊180重量份、陈皮60重量份、生薏米160重量份、大枣120重量份。
3.根据权利要求1所述的强筋壮骨的中药组合物,其特征在于,所述中药组合物的剂型为酒剂、汤剂、丸剂、膏剂中的任何一种。
4.根据权利要求3所述的强筋壮骨的中药组合物,其特征在于,所述中药组合物的剂型为酒剂。
5.根据权利要求4所述的强筋壮骨的中药组合物,其特征在于,所述酒剂的制备方法包括如下步骤:
(1)取各中药组分,分别经净制、干燥后粉碎,得到各中药细粉;将所述各中药细粉混合均匀,得到混合药粉;
(2)向混合药粉中加入白酒或米酒,密封浸泡,之后过滤去渣,得到中药酒液;
(3)向中药酒液中加入冰糖,搅拌使溶解均匀,即得。
6.根据权利要求5所述的强筋壮骨的中药组合物,其特征在于,步骤(1)中,所述各中药细粉的粒径为60-100目。
7.根据权利要求5所述的强筋壮骨的中药组合物,其特征在于,步骤(2)中,所述混合药粉和白酒/米酒之间的质量比为1:3.5-4.5,所述白酒为酒精度不低于42°的纯粮食酒,所述米酒为酒精度为40°的米酒。
8.根据权利要求5所述的强筋壮骨的中药组合物,其特征在于,步骤(2)中,先向混合药粉中加入60%的白酒或米酒,密封浸泡80-100天,过滤,然后向过滤之后的药渣中加入剩余的白酒或米酒,密封浸泡50-70天,过滤去渣,合并两次滤液,得到中药酒液。
9.根据权利要求5所述的强筋壮骨的中药组合物,其特征在于,步骤(3)中,所述中药酒液的体积与冰糖的质量之比为500mL:30-40g。
10.权利要求1-4任一项所述的强筋壮骨的中药组合物在制备治疗骨关节炎、肢体麻木、食欲不振、气短神疲、夜尿频多、视力衰退、耳鸣失聪、早生白发、免疫力下降、妇女宫寒的药物中的应用。
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