CN112741889A

CN112741889A - A Chinese medicinal preparation for treating syphilis and condyloma acuminatum, and its preparation method

Info

Publication number: CN112741889A
Application number: CN202110133567.6A
Authority: CN
Inventors: 明炳春
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-02-01
Filing date: 2021-02-01
Publication date: 2021-05-04

Abstract

The invention discloses a Chinese medicinal preparation for treating syphilis and condyloma acuminatum and a preparation method thereof, wherein the preparation comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 10 parts of oriental wormwood, 10 parts of poria cocos, 10 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 7 parts of spina gleditsiae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 7 parts of cortex dictamni, 8 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of zedo; the preparation method comprises the following steps: pulverizing the medicinal materials, adding refined honey, mixing, fermenting, making into pill, and sterilizing. The traditional Chinese medicine preparation can effectively solve the problems that the existing medicine has poor treatment effect on syphilis and condyloma acuminatum, side effect method and can not thoroughly cure diseases.

Description

A Chinese medicinal preparation for treating syphilis and condyloma acuminatum, and its preparation method

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum and a preparation method thereof.

Background

Syphilis is a chronic, classical sexually transmitted disease caused by Treponema Pallidum (TP), which can almost invade the organs of the body and produce a wide variety of symptoms and signs. Syphilis may also be asymptomatic and latent for many years. Syphilis is transmitted mainly through sexual intercourse, and also transmitted to the next generation through placenta to cause fetal syphilis.

Condyloma acuminata is a sexually transmitted disease caused by infection of Human Papilloma Virus (HPV), and most of the condyloma acuminatum occurs in the foreskin, glans penis, female pudendum or near anus. The lesions first appeared as reddish, soft papules, which thereafter gradually increased in number, increased in volume, and had a bumpy surface, usually without subjective symptoms.

At present, the conventional treatment methods aiming at syphilis and condyloma acuminatum are implemented by treatment through antibiotics, hormones, lasers, operations and the like, but the methods have the problems of temporary solution and permanent solution, poor treatment effect, difficulty in effectively removing pathogenic viruses and curing diseases, and replacement of economic and psychological dual pressure for patients. And the long-term use of a large amount of antibiotics and hormones can cause the flora imbalance of the gastrointestinal tract to be disordered, and other diseases are easily induced.

Disclosure of Invention

Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum and a preparation method thereof, and the traditional Chinese medicine preparation can effectively solve the problems of poor treatment effect, large side effect and incapability of completely curing diseases of the existing medicines in the aspect of treating syphilis and condyloma acuminatum.

In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problems is as follows:

a traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 10-20 parts of astragalus membranaceus, 5-15 parts of oriental wormwood, 5-15 parts of poria cocos, 5-15 parts of fructus forsythiae, 5-15 parts of honeysuckle, 5-15 parts of wild chrysanthemum flower, 2-8 parts of pangolin, 4-12 parts of herba patriniae, 4-12 parts of spina gleditsiae, 0.2-0.7 part of bear gall powder, 5-15 parts of scutellaria baicalensis, 2-8 parts of Hainan sediment, 2-8 parts of radix angelicae, 4-12 parts of radix paeoniae alba, 4-12 parts of cortex dictamni, 4-14 parts of penthorum chinense pursh, 4-12 parts of rehmannia glutinosa, 2-8 parts of sargentgloryvine stem, 5-15 parts of codonopsis pilosula, 4-12 parts of ligusticum wallichii, 4-12 parts of salvia miltiorrhiza, 2-8 parts of radix curcumae, 2-8 parts of rhizoma sparganii, 2-8 parts of zedoary, 2-8 parts.

Further, 13-17 parts of astragalus root, 8-12 parts of oriental wormwood, 8-12 parts of tuckahoe, 8-12 parts of forsythia, 8-12 parts of honeysuckle, 8-12 parts of wild chrysanthemum flower, 4-7 parts of pangolin, 5-9 parts of herba patriniae, 5-9 parts of spina gleditsiae, 0.3-0.6 part of bear gall powder, 8-12 parts of scutellaria root, 3-7 parts of Hainan sediment and 3-6 parts of angelica dahurica, 5-9 parts of white paeony root, 5-9 parts of cortex dictamni, 6-9 parts of penthorum chinense pursh, 5-9 parts of rehmannia root, 3-7 parts of sargentgloryvine stem, 7-10 parts of codonopsis pilosula, 5-9 parts of ligusticum wallichii, 5-9 parts of salvia miltiorrhiza, 3-6 parts of radix curcumae, 3-6 parts of rhizoma sparganii, 3-6 parts of zedoary, 3-6 parts of rhizoma dioscoreae bulbifer, 7-10 parts of lithospermum and 2-4 parts of liquorice.

Further, the paint comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 10 parts of oriental wormwood, 10 parts of poria cocos, 10 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 7 parts of spina gleditsiae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 7 parts of cortex dictamni, 8 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of zedo.

In the above scheme, the astragalus: sweet in nature and taste, slightly warm, entering spleen and lung meridians. Has effects in invigorating spleen, strengthening middle warmer, invigorating yang, lifting sink, invigorating defensive qi, consolidating superficial resistance, promoting urination, removing toxic materials, and promoting granulation. The astragalus can promote the metabolism of organisms, resist fatigue and promote the renewal of serum and liver proteins; can enhance and regulate organism immunity, promote interferon system, and improve disease resistance of organism; has slight inhibition effect on cytopathic effect caused by various viruses such as influenza virus and the like; has wide antibacterial effect.

Herba artemisiae scopariae: bitter in property, pungent and slightly cold in property, entering spleen, stomach, liver and gallbladder meridians. Has effects of clearing away damp-heat and eliminating jaundice. Herba Artemisiae Scopariae can promote bile secretion, and can be used for treating infectious icterohepatitis. The herba Artemisiae Scopariae has antibacterial effect on Staphylococcus aureus, has strong inhibitory effect on influenza virus (PR8 strain), and also has antifungal effect.

Tuckahoe, poria cocos: sweet, bland and neutral in nature and flavor, entering liver and stomach meridians. Has effects in removing toxic materials, eliminating dampness, and smoothing joint movement. Can be used for treating limb spasm and arthralgia and myalgia due to syphilis and mercury poisoning; poria cocos can enter collaterals to eliminate accumulated toxicity of damp-heat.

Fructus forsythiae: bitter in property and flavor and neutral in nature, entering liver and stomach meridians. Has hemostatic, menstruation regulating, blood stasis dispelling, analgesic, toxic materials clearing away, and repercussive effects. Fructus forsythiae has antiallergic, antibacterial, sialidase resisting, antiviral, antibacterial, and photosensitizing effects.

Honeysuckle flower: sweet and cold in nature and flavor, entering lung and stomach meridians. Has effects in clearing away heat and toxic materials, relieving inflammation, and relieving swelling. Has therapeutic effect on dysentery due to toxic heat and multiple infectious diseases. The flos Lonicerae has effects of resisting pathogenic microorganism, resisting virus, resisting inflammation, and promoting phagocytic function of inflammatory cell. Has obvious cytotoxic effect on sarcoma S180 and Ehrlich ascites carcinoma.

Wild chrysanthemum flower: bitter, pungent and slightly cold in nature, entering liver and heart meridians. Has the functions of clearing away heat and toxic material, purging fire and calming the liver. Can be used for treating furuncle, carbuncle, swelling, conjunctival congestion, swelling and pain, headache, and vertigo.

Herba Patriniae: cool in nature, pungent and bitter in flavor, and entering liver, stomach and large intestine meridians. Has the effects of clearing away heat and toxic materials, eliminating phlegm, and promoting pus discharge. Can be used for treating intestinal abscess, pulmonary abscess, dysentery, puerperal abdominal pain due to blood stasis, carbuncle, furuncle, etc.

Spina gleditsiae: nature and taste: pungent in flavor and warm in nature, it enters liver and stomach meridians. Has the functions of eliminating swelling, expelling toxin, discharging pus and killing pests. Can be used for treating carbuncle, cellulitis, scabies, leprosy, and suppurative sore and tinea.

Bear gall powder is bitter and cold in nature and enters liver, gall, lung and large intestine meridians. Has the effects of clearing heat, moistening dryness, removing toxic substances, and relieving cough and asthma. Can be used for treating fever, thirst, conjunctival congestion, pharyngitis, jaundice, pertussis, asthma, diarrhea, dysentery, constipation, carbuncle, sore, and toxic swelling.

Baical skullcap root, radix Scutellariae, with bitter and cold properties, enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing toxic substance, stopping bleeding, and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Hainan is pungent, bitter and slightly warm in nature and enters spleen, stomach and kidney meridians. Has effects of activating qi-flowing, relieving pain, warming middle-jiao, relieving vomit, and absorbing qi and relieving asthma. Has the functions of guiding medicine downwards and guiding toxin downwards.

Bai Zhi has pungent and warm nature and flavor, and enters lung, spleen and stomach meridians. Has effects in relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, relieving swelling, promoting pus discharge, promoting granulation, relieving pain, dispelling pathogenic wind, and relieving itching.

Bai Shao is bitter and sour in property and slightly cold in property, entering liver and spleen meridians. Has effects in nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain, and suppressing liver yang. Can be used for treating blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache, and vertigo. It can also be used for treating hemorrhoid complicated by anal fistula, scabies, and pterygium.

And (3) preparing cortex dictamni: nature and taste: bitter and cold. It enters spleen, stomach and bladder meridians. Has the functions of clearing away heat, eliminating dampness, dispelling wind and removing toxic material. Damp-heat sore, yellow water dripping, eczema, rubella, scabies, sore, scabies, rheumatism and pyretic arthralgia. It can be used for treating scabies, tinea, red bayberry, sore, and toxic heat.

Penthorum chinense Pursh has sweet and warm nature and flavor, and enters liver and kidney meridians. Has effects of promoting diuresis, removing dampness, removing blood stasis and relieving pain. Has the effect of relieving liver injury. The penthorum chinense Pursh contains multiple effective components, has liver protecting effect, and can reduce damage of alcohol and medicine to liver.

Rehmannia root, radix rehmanniae is sweet in flavor and taste, cold in nature, and enters heart, liver and kidney meridians. Can be used for treating heat entering nutrient-blood, epidemic heat with macula, hematemesis, epistaxis, impairment of yin by heat disease, crimson polydipsia, constipation due to body fluid consumption, and sore throat.

The property of the sargentgloryvine stem is bitter and cold, and enters the large intestine channel. Has the effects of clearing away heat and toxic materials and relieving swelling. Can be used for treating appendicitis, mastitis, parotitis, pulmonary tuberculosis, and hemoptysis.

Codonopsis pilosula is sweet in nature and neutral in flavor, and enters spleen and lung meridians. Has effects of invigorating spleen, invigorating qi, and promoting fluid production. Can be used for treating weakness of spleen and stomach, deficiency of both qi and blood, asthenia, anorexia, thirst, chronic diarrhea, proctoptosis, and unhealed skin and external diseases.

Chuan Xiong is pungent in flavor and warm in nature, entering liver and gallbladder meridians. Has effects of activating qi-flowing, resolving stagnation, dispelling wind-dryness and dampness, promoting blood circulation and relieving pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Chuan Xiong can ascend to the vertex and enter the blood system and descend to the blood sea, so it is used to regulate the pulse of the people, break the symptoms and stagnation of blood, nourish new blood, promote granulation, nose flood, hematemesis and drowning, hemorrhoids and fistula, cerebral carbuncle and back, scrofula and gall, sores and scabies, and discharge pus and remove blood stasis.

Salvia miltiorrhiza, bitter in flavor and slightly cold, enters heart and liver meridians. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Yu jin is pungent, bitter and cold in flavor, and enters heart, lung and liver meridians. Has effects of promoting blood circulation, relieving pain, activating qi-flowing, resolving stagnation, clearing heart fire, cooling blood, promoting bile flow, and eliminating jaundice. Can be used for treating pricking pain in chest and hypochondrium, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, breast pain, coma due to fever, epilepsy, hematemesis, hemorrhage, jaundice, and dark urine.

San Leng is pungent, mild and bitter in flavor and enters liver and spleen meridians. Has the effects of breaking blood, promoting qi circulation, removing food retention and relieving pain. Can be used for treating abdominal mass, dysmenorrhea, amenorrhea due to blood stasis, thoracic obstruction, cardialgia, and food stagnation and distending pain.

E Zhu is pungent, bitter and warm in nature and enters liver and spleen meridians. Has effects of activating qi-flowing, removing blood stasis, resolving food stagnation and relieving pain. Can be used for treating blood qi and heart pain, food stagnation, abdominal distention and pain, amenorrhea due to blood stagnation, dysmenorrhea, abdominal mass, tumor, and traumatic injury. Has antibacterial, leukocyte increasing, liver protecting, and antiinflammatory effects.

Huang Si Jiang is pungent, bitter and warm in flavor, and enters spleen and liver meridians. Has effects of removing blood stasis, activating qi-flowing, dredging channels and relieving pain. Can be used for treating chest and hypochondrium stabbing pain, thoracic obstruction, cardialgia, dysmenorrhea, amenorrhea, abdominal mass, rheumatism, shoulder and arm pain, and traumatic injury with swelling and pain.

Zi Cao is sweet, salty and cold in nature and enters heart and liver meridians. Has effects of cooling blood, promoting blood circulation, removing toxic substance and promoting eruption. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, scald due to hot water and fire, malignant boil, and tinea.

Licorice root, radix Glycyrrhizae is sweet in nature and flavor, neutral in nature, and enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, and sore, and relieving drug toxicity and pungency.

The white honey can regulate and tonify spleen and stomach, and the sesame oil has the functions of moistening dryness, relaxing bowels, detoxifying and promoting granulation. It can be used for treating constipation due to intestinal dryness, ascariasis, abdominal pain due to dyspepsia, sore, ulcer, scabies, tinea, and chapped skin.

The medicine has scientific and reasonable matching, and the different medicines have mutual synergistic effect, play the roles of detoxifying and promoting tissue regeneration, breaking blood and detoxifying and guiding toxin downwards, and promote the toxin in the body of a patient to be discharged through excrement, so that the broken and ulcerated part of the condyloma is scabbed and falls off, and the skin tissue is recovered to be normal.

A preparation method of a traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following steps:

(1) breaking cell wall of the above materials, and pulverizing to obtain powder;

(2) heating the white honey until water drops to form beads, adding the white honey into the powder in the step (1), uniformly mixing, kneading into a dough, adding the sesame oil into the dough, and continuously kneading until the dough is cured;

(3) carrying out indoor sweating and fermentation on the medicinal mass in the step (2) for 18-30 days;

(4) dividing the medicinal mass obtained in the step (3) into a plurality of pills and sterilizing to obtain the traditional Chinese medicine composition.

Further, the mass ratio of the white honey to the powder in the step (2) is 1: 1-1.5.

Further, the mass ratio of the white honey to the powder in the step (2) is 1: 1.5.

Further, the mass ratio of the sesame oil to the medicinal mass in the step (2) is 1: 8-12.

Further, the mass ratio of the sesame oil to the medicinal mass in the step (2) is 1: 10.

Further, the humidity in the chamber in the step (3) is 40-60%, and the temperature is 33-37 ℃.

Further, the specific sweating fermentation process in the step (3) is as follows: fermenting the medicinal group indoors for 2-3 days, dividing the medicinal group into two parts, kneading into two parts, stacking, fermenting for 2-3 days, dividing the medicinal group into four parts, kneading into four parts, stacking, and fermenting for 25-30 days.

Further, the specific sweating fermentation process in the step (3) is as follows: fermenting the medicinal group in room for 3 days, dividing the medicinal group into two parts, kneading into two parts, stacking, fermenting for 3 days, dividing the medicinal group into four parts, kneading into four parts, stacking, fermenting for 9 times for 27 days.

According to the scheme, the medicinal mass is fermented under the conditions of constant temperature and humidity, the medicinal property of the medicine can be changed by utilizing the action of microorganisms in the medicine, the medicinal effect is improved, the toxic and side effects of the medicine are reduced, and the treatment effect is further improved.

The beneficial effects produced by the invention are as follows:

in the theory of traditional Chinese medicine, treponema pallidum causing syphilis and human papilloma virus causing condyloma acuminatum both belong to liver endotoxin, the liver is an important organ of human metabolism, the liver stores blood mainly, and the gallbladder dredges and drains mainly, so that the treponema pallidum has the functions of storing and regulating blood. When the spleen is strengthened, the astragalus, the codonopsis pilosula, the white paeony root, the honeysuckle, the wild chrysanthemum flower, the lithospermum and the forsythia are mutually and synergistically acted to promote the functions of the spleen and the stomach, exert the effects of detoxification and granulation promotion, and simultaneously tonify the middle and enter the lung to prevent the body from being injured by excessive catharsis; the angelica dahurica, the spina gleditsiae, the radix curcumae and the rhizoma sparganii have mutual synergistic effect, enter the liver to break blood, promote qi circulation to expel toxin and discharge toxin in liver blood; hainan sink, rhizoma ligustici wallichii, salvia miltiorrhiza and poria cocos are mutually synergistic, so that blood is guided to descend, and toxin is guided to descend to large and small intestines, kidneys and bladder, and the excretion of toxins in blood is accelerated; penthorum chinense pursh, herba artemisiae scopariae and rhizoma dioscoreae nipponicae play roles of protecting the liver, promoting the functions of the liver and gallbladder and accelerating the blood metabolism in the liver; the rest medicines can promote the recovery of body functions, improve body resistance, promote the normal functions of skin striae and defecation by clearing away heat and toxic materials, resisting inflammation, resisting virus and the like, further excrete toxins and treat diseases.

Detailed Description

Example 1

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 7 parts of oriental wormwood, 8 parts of poria cocos, 10 parts of fructus forsythiae, 6 parts of honeysuckle, 7 parts of wild chrysanthemum flower, 6 parts of pangolin scales, 10 parts of patrinia, 6 parts of spina gleditsiae, 0.4 part of bear gall powder, 12 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 8 parts of radix paeoniae alba, 7 parts of cortex dictamni, 5 parts of penthorum chinense pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 5 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 5 parts of salvia miltiorrhiza, 5 parts of radix curcumae, 3 parts of rhizoma sparganii, 5 parts of curcuma.

(1) removing impurities from the above medicinal materials, breaking cell wall, and pulverizing to obtain powder;

(2) placing white honey into an enamel container, heating in a water-proof manner until water drops form beads, adding the white honey into the powder obtained in the step (1), uniformly mixing, kneading into a dough, wherein the mass ratio of the white honey to the powder is 1:1, adding sesame oil into the dough, and continuously kneading until the dough is cured, wherein the mass ratio of the sesame oil to the dough is 1: 8;

(3) fermenting the medicinal group indoors for 2 days, dividing the medicinal group into two parts, kneading into two parts, stacking, fermenting for 2 days, dividing the medicinal group into four parts, kneading into four parts, stacking, and fermenting for 18 days;

(4) and (4) dividing the medicinal mass obtained in the step (3) into a plurality of pills of 15 g/pill, and performing microwave sterilization for 15min to obtain the medicinal composition.

Example 2

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 20 parts of astragalus membranaceus, 15 parts of oriental wormwood, 12 parts of poria cocos, 12 parts of fructus forsythiae, 14 parts of honeysuckle, 6 parts of wild chrysanthemum flower, 8 parts of pangolin scales, 12 parts of patrinia, 9 parts of spina gleditsiae, 0.7 part of bear gall powder, 12 parts of scutellaria baicalensis, 6 parts of Hainan sinension, 6 parts of radix angelicae, 12 parts of radix paeoniae alba, 10 parts of cortex dictamni, 12 parts of penthorum chinense Pursh, 13 parts of rehmannia glutinosa, 7 parts of sargentgloryvine stem, 12 parts of codonopsis pilosula, 11 parts of ligusticum wallichii, 11 parts of salvia miltiorrhiza, 7 parts of radix curcumae, 7 parts of rhizoma sparganii, 3.

(2) placing white honey into an enamel container, heating in a water-proof manner until water drops form beads, adding the white honey into the powder obtained in the step (1), uniformly mixing, kneading into a dough, adding sesame oil into the dough until the dough is cured, wherein the mass ratio of the sesame oil to the dough is 1: 1.5;

(3) fermenting the medicinal group indoors for 3 days, dividing the medicinal group into two parts, kneading into two parts, stacking, continuously sweating, fermenting for 3 days, dividing the medicinal group into four parts, continuously kneading into four parts, stacking, repeating the steps, and fermenting for 27 days;

Example 3

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 10 parts of oriental wormwood, 10 parts of poria cocos, 10 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 7 parts of spina gleditsiae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 7 parts of cortex dictamni, 8 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of zedo.

(2) placing white honey into an enamel container, heating in a water-proof manner until water drops form beads, adding the white honey into the powder obtained in the step (1), uniformly mixing, kneading into a dough, wherein the mass ratio of the white honey to the powder is 1:1.25, adding sesame oil into the dough, and continuously kneading until the dough is cured, wherein the mass ratio of the sesame oil to the dough is 1: 10;

Comparative example 1

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 10 parts of oriental wormwood, 10 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sinension, 5 parts of radix angelicae, 7 parts of cortex dictamni, 8 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of curcuma zedoary, 4.5 parts of rhizoma dioscoreae nipponic.

A Chinese medicinal preparation for treating syphilis and condyloma acuminatum is prepared as in example 3.

Comparative example 2

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 5 parts of astragalus membranaceus, 3 parts of oriental wormwood, 10 parts of poria cocos, 3 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 7 parts of spina gleditsiae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 3 parts of cortex dictamni, 3 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 1 part.

Comparative example 3

Comparative example 4

A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 10 parts of oriental wormwood, 10 parts of poria cocos, 10 parts of dandelion, 10 parts of Chinese violet, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of patrinia, 7 parts of spina gleditsiae, 0.5 part of bezoar, 10 parts of scutellaria baicalensis, 5 parts of achyranthes bidentata, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 7 parts of cortex dictamni, 8 parts of penthorum chinense pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of ginseng, 7 parts of ligusticum wallichii, 7 parts of folium isatidis, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of zedoary, 4.

Comparative example 5

A Chinese medicinal preparation for treating syphilis and condyloma acuminatum has the same specific formula as in example 3.

(2) placing white honey into an enamel container, heating in a water-proof manner until water drops form beads, adding the white honey into the powder obtained in the step (1), uniformly mixing, kneading into a dough, wherein the mass ratio of the white honey to the powder is 1:0.8, adding sesame oil into the dough, and continuously kneading until the dough is cured, wherein the mass ratio of the sesame oil to the dough is 1: 10;

(3) fermenting the medicated ball indoors for 10 days;

Test examples

One, searching 180 patients with condyloma acuminatum, wherein 90 men and 90 women have no significant difference between the men and the women, and have comparability, the men and the women are randomly divided into 6 groups, 15 men and 15 women in each group take the pills in example 3 and comparative examples 1-5 respectively, and the pills are taken continuously for 5 months and three times a day, one pill at a time, and the symptoms before taking, 1 week after taking, 2 weeks after taking, 4 weeks after taking, 8 weeks after taking and 12 weeks after taking are recorded, and the specific results are shown in tables 1-2.

The evaluation standard of the curative effect is as follows:

the method has the following advantages: the wart on the surface of the patient is increased and then reduced or disappeared;

and (4) invalidation: the wart on the surface of the patient has no obvious change.

Effective rate is 100% of effective number/total number

Table 1: statistics for treatment of condyloma acuminatum

Table 2: statistics for treatment rate of condyloma acuminatum

	Number of people (human)	Number of valid persons (human)	Invalid number of people (human)	Effective rate (%)
					Example 1	30	28	2	93.3％
Comparative example 1	30	15	15	50％
					Comparative example 2	30	14	16	46.7％
Comparative example 3	30	14	16	46.7％
					Comparative example 4	30	12	18	40％
Comparative example 5	30	21	9	70％

As can be seen from the data in tables 1 and 2, the pill in example 1 of the present application has a good treatment effect on condyloma acuminatum, after being taken for 12 weeks, pathogenic toxins in the body can be completely discharged, so that the skin is restored to a normal state, and the effective rate of the pill in example 1 on condyloma acuminatum reaches more than 90%. In the comparative examples 1-5, because the components, the proportion relationship, the components of the formula, the preparation method and the like in the formula are changed, the treatment effect in the comparative examples 1-5 is far worse than that in the example 1, and the traditional Chinese medicine composition and the preparation method thereof are proved to be scientific and reasonable.

After blood test and reexamination of the patients treated by the traditional Chinese medicine preparation in the example 1, the virus detection results in the patients are negative, and all indexes are recovered to be normal.

Secondly, searching 180 patients with primary syphilis, wherein 90 men and 90 women have no significant difference among the men and have comparability, the men and the women have no significant difference among the women and have comparability, the men and the women are randomly divided into 6 groups, 15 men and 15 women in each group take the pills in example 3 and comparative examples 1-5 respectively, the pills are taken for 5 months and three times a day, one pill is taken for each time, and symptoms before taking, 1 week after taking, 8 weeks after taking, 16 weeks after taking, 24 weeks after taking and 36 weeks after taking are recorded, and specific results are shown in tables 3-4.

The evaluation standard of the curative effect is as follows:

the method has the following advantages: the dull red macula and the hard chancroid on the body surface of the patient are reduced or disappeared after getting worse;

and (4) invalidation: the dark red macula and chancroid on the body surface of the patient have no obvious change.

Effective rate is 100% of effective number/total number

Table 3: statistics of treatment for stage one syphilis

Table 4: treatment rate statistics for stage one syphilis

As can be seen from the data in tables 3 and 4, the pill in example 1 of the present application has a very good therapeutic effect on dark red macule and chancroid caused by syphilis, and after taking the pill for 36 weeks, pathogenic toxins in the body can be completely excreted, so that the skin and lymph can be restored to a normal state, and the effective rate of the pill in example 1 on syphilis reaches more than 90%. For patients with syphilis in second and third stages, the treatment time needs to be prolonged or even doubled due to more toxin, the effect period after treatment can be prolonged or even doubled, and the patients can be cured after taking the drug. In the comparative examples 1-5, because the components, the proportion relationship, the components of the formula, the preparation method and the like in the formula are changed, the treatment effect in the comparative examples 1-5 is far worse than that in the example 1, and the traditional Chinese medicine composition and the preparation method thereof are proved to be scientific and reasonable.

Claims

1. A traditional Chinese medicine preparation for treating syphilis and condyloma acuminatum is characterized by comprising the following components in parts by weight: 10-20 parts of astragalus membranaceus, 5-15 parts of oriental wormwood, 5-15 parts of poria cocos, 5-15 parts of fructus forsythiae, 5-15 parts of honeysuckle, 5-15 parts of wild chrysanthemum flower, 2-8 parts of pangolin, 4-12 parts of herba patriniae, 4-12 parts of spina gleditsiae, 0.2-0.7 part of bear gall powder, 5-15 parts of scutellaria baicalensis, 2-8 parts of Hainan sediment, 2-8 parts of radix angelicae, 4-12 parts of radix paeoniae alba, 4-12 parts of cortex dictamni, 4-14 parts of penthorum chinense pursh, 4-12 parts of rehmannia glutinosa, 2-8 parts of sargentgloryvine stem, 5-15 parts of codonopsis pilosula, 4-12 parts of ligusticum wallichii, 4-12 parts of salvia miltiorrhiza, 2-8 parts of radix curcumae, 2-8 parts of rhizoma sparganii, 2-8 parts of zedoary, 2-8 parts.

2. The Chinese medicinal preparation for treating syphilis and condyloma acuminatum according to claim 1, wherein the Chinese medicinal preparation comprises 13-17 parts of astragalus membranaceus, 8-12 parts of oriental wormwood, 8-12 parts of poria cocos, 8-12 parts of fructus forsythiae, 8-12 parts of honeysuckle, 8-12 parts of wild chrysanthemum flower, 4-7 parts of pangolin scales, 5-9 parts of herba patriniae, 5-9 parts of spina gleditsiae, 0.3-0.6 part of bear gall powder, 8-12 parts of scutellaria baicalensis, 3-7 parts of Hainan sediment, 3-6 parts of radix angelicae, 5-9 parts of radix paeoniae alba, 5-9 parts of cortex dictamni, 6-9 parts of penthorum chinense Pursh, 5-9 parts of rehmannia glutinosa, 3-7 parts of sargentgloryvine stem, 7-10 parts of codonopsis pilosula, 5-9 parts of ligusticum wallichii, 5-9 parts of salvia miltiorrhiza, 3-6 parts of, 3-6 parts of turmeric, 7-10 parts of lithospermum and 2-4 parts of liquorice.

3. The traditional Chinese medicine preparation for treating syphilis and condyloma acuminata according to claim 1 or 2, which comprises the following components in parts by weight: 15 parts of astragalus membranaceus, 10 parts of oriental wormwood, 10 parts of poria cocos, 10 parts of fructus forsythiae, 10 parts of honeysuckle, 10 parts of wild chrysanthemum flower, 5 parts of pangolin scales, 7 parts of herba patriniae, 7 parts of spina gleditsiae, 0.5 part of bear gall powder, 10 parts of scutellaria baicalensis, 5 parts of Hainan sediment, 5 parts of radix angelicae, 7 parts of radix paeoniae alba, 7 parts of cortex dictamni, 8 parts of penthorum chinense Pursh, 7 parts of rehmannia glutinosa, 5 parts of sargentgloryvine stem, 9 parts of codonopsis pilosula, 7 parts of ligusticum wallichii, 7 parts of salvia miltiorrhiza, 4.5 parts of radix curcumae, 4.5 parts of rhizoma sparganii, 4.5 parts of zedo.

4. A method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum as claimed in claims 1-3, which comprises the following steps:

5. The method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum as claimed in claim 4, wherein the mass ratio of the white honey to the powder in step (2) is 1: 1-1.5.

6. The method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum according to claim 4, wherein the mass ratio of the sesame oil to the medicinal mass in step (2) is 1: 8-12.

7. The method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum as claimed in claim 4, wherein the humidity in the chamber in step (3) is 40-60% and the temperature is 33-37 ℃.

8. The method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum according to claim 4, wherein the specific sweating and fermenting process in step (3) comprises the following steps: fermenting the medicinal group indoors for 2-3 days, dividing the medicinal group into two parts, kneading into two parts, stacking, fermenting for 2-3 days, dividing the medicinal group into four parts, kneading into four parts, stacking, and fermenting for 25-30 days.

9. The method for preparing a Chinese medicinal preparation for treating syphilis and condyloma acuminatum according to claim 8, wherein the specific sweating and fermenting process in step (3) comprises the following steps: fermenting the medicinal group in room for 3 days, dividing the medicinal group into two parts, kneading into two parts, stacking, fermenting for 3 days, dividing the medicinal group into four parts, kneading into four parts, stacking, fermenting for 9 times for 27 days.