CN112704234A - Nutritional composition containing composite peptide and probiotics and preparation method thereof - Google Patents
Nutritional composition containing composite peptide and probiotics and preparation method thereof Download PDFInfo
- Publication number
- CN112704234A CN112704234A CN202011473752.1A CN202011473752A CN112704234A CN 112704234 A CN112704234 A CN 112704234A CN 202011473752 A CN202011473752 A CN 202011473752A CN 112704234 A CN112704234 A CN 112704234A
- Authority
- CN
- China
- Prior art keywords
- parts
- peptide
- probiotics
- nutritional composition
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 166
- 239000006041 probiotic Substances 0.000 title claims abstract description 115
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 115
- 239000000203 mixture Substances 0.000 title claims abstract description 82
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 80
- 239000002131 composite material Substances 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 20
- 150000001875 compounds Chemical class 0.000 claims abstract description 43
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 35
- 239000002562 thickening agent Substances 0.000 claims abstract description 33
- 235000015203 fruit juice Nutrition 0.000 claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 27
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 27
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 24
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 24
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 24
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 24
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 24
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 24
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 24
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 24
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 24
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 24
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 24
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims abstract description 24
- 235000021283 resveratrol Nutrition 0.000 claims abstract description 24
- 229940016667 resveratrol Drugs 0.000 claims abstract description 24
- 239000011675 vitamin B5 Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000845 maltitol Substances 0.000 claims abstract description 21
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 4
- 238000003756 stirring Methods 0.000 claims description 30
- 239000011259 mixed solution Substances 0.000 claims description 27
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 20
- 235000010449 maltitol Nutrition 0.000 claims description 20
- 229940035436 maltitol Drugs 0.000 claims description 20
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 102000008186 Collagen Human genes 0.000 claims description 17
- 108010035532 Collagen Proteins 0.000 claims description 17
- 229920001436 collagen Polymers 0.000 claims description 17
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 229920001202 Inulin Polymers 0.000 claims description 16
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 16
- 229940029339 inulin Drugs 0.000 claims description 16
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims description 15
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 15
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims description 15
- 102000011632 Caseins Human genes 0.000 claims description 13
- 108010076119 Caseins Proteins 0.000 claims description 13
- 229920002907 Guar gum Polymers 0.000 claims description 13
- 235000004298 Tamarindus indica Nutrition 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 13
- 239000000665 guar gum Substances 0.000 claims description 13
- 235000010417 guar gum Nutrition 0.000 claims description 13
- 229960002154 guar gum Drugs 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 229920001282 polysaccharide Polymers 0.000 claims description 13
- 239000005017 polysaccharide Substances 0.000 claims description 13
- 229940080237 sodium caseinate Drugs 0.000 claims description 13
- 241000186000 Bifidobacterium Species 0.000 claims description 12
- 244000199866 Lactobacillus casei Species 0.000 claims description 12
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 12
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 12
- 229940017800 lactobacillus casei Drugs 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 230000000529 probiotic effect Effects 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 5
- 235000015197 apple juice Nutrition 0.000 claims description 5
- 235000015120 cherry juice Nutrition 0.000 claims description 5
- 238000011049 filling Methods 0.000 claims description 5
- 235000015201 grapefruit juice Nutrition 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 235000013525 pomegranate juice Nutrition 0.000 claims description 5
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 240000004584 Tamarindus indica Species 0.000 claims 1
- 230000036039 immunity Effects 0.000 abstract description 20
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 15
- 241000282414 Homo sapiens Species 0.000 abstract description 11
- 230000002708 enhancing effect Effects 0.000 abstract description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- 239000013589 supplement Substances 0.000 abstract description 5
- 230000004083 survival effect Effects 0.000 abstract description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 239000011573 trace mineral Substances 0.000 abstract description 4
- 235000013619 trace mineral Nutrition 0.000 abstract description 4
- 230000001580 bacterial effect Effects 0.000 abstract description 3
- 239000008369 fruit flavor Substances 0.000 abstract description 3
- 229910052742 iron Inorganic materials 0.000 abstract description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 2
- 229930003268 Vitamin C Natural products 0.000 abstract description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 2
- 239000011707 mineral Substances 0.000 abstract description 2
- 235000010755 mineral Nutrition 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 235000019605 sweet taste sensations Nutrition 0.000 abstract description 2
- 235000019154 vitamin C Nutrition 0.000 abstract description 2
- 239000011718 vitamin C Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 35
- 241001092040 Crataegus Species 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 12
- 241000596504 Tamarindus Species 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 9
- 230000009286 beneficial effect Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 5
- 240000000851 Vaccinium corymbosum Species 0.000 description 5
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 5
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 5
- 235000021014 blueberries Nutrition 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 238000003304 gavage Methods 0.000 description 5
- 230000000968 intestinal effect Effects 0.000 description 5
- 230000035755 proliferation Effects 0.000 description 5
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 5
- 239000011669 selenium Substances 0.000 description 5
- 229910052711 selenium Inorganic materials 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- 235000019156 vitamin B Nutrition 0.000 description 5
- 239000011720 vitamin B Substances 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 4
- 229930003270 Vitamin B Natural products 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 108010062580 Concanavalin A Proteins 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 210000002249 digestive system Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000012163 sequencing technique Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229930003448 Vitamin K Natural products 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 210000001872 metatarsal bone Anatomy 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000000813 small intestine Anatomy 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000019158 vitamin B6 Nutrition 0.000 description 2
- 239000011712 vitamin K Substances 0.000 description 2
- 235000019168 vitamin K Nutrition 0.000 description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- 229940046010 vitamin k Drugs 0.000 description 2
- 108020004465 16S ribosomal RNA Proteins 0.000 description 1
- OCKGFTQIICXDQW-ZEQRLZLVSA-N 5-[(1r)-1-hydroxy-2-[4-[(2r)-2-hydroxy-2-(4-methyl-1-oxo-3h-2-benzofuran-5-yl)ethyl]piperazin-1-yl]ethyl]-4-methyl-3h-2-benzofuran-1-one Chemical compound C1=C2C(=O)OCC2=C(C)C([C@@H](O)CN2CCN(CC2)C[C@H](O)C2=CC=C3C(=O)OCC3=C2C)=C1 OCKGFTQIICXDQW-ZEQRLZLVSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000010359 Newcastle Disease Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003571 Vitamin B5 Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 244000000015 environmental pathogen Species 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- AYOOGWWGECJQPI-NSHDSACASA-N n-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-3-(3-propan-2-yloxy-1h-pyrazol-5-yl)imidazo[4,5-b]pyridin-5-amine Chemical compound N1C(OC(C)C)=CC(N2C3=NC(N[C@@H](C)C=4N=CC(F)=CN=4)=CC=C3N=C2)=N1 AYOOGWWGECJQPI-NSHDSACASA-N 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008621 organismal health Effects 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/125—Casei
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/249—Thermophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention belongs to the technical field of food processing, and particularly relates to a nutritional composition containing composite peptide and probiotics and a preparation method thereof. The nutritional composition containing the compound peptide and the probiotics provided by the invention comprises the compound peptide, the probiotics, fruit juice, hawthorn powder, prebiotics and vitamin B5Vitamin B6Maltitol, 13 parts of thickening agent, resveratrol and water. The peptide in the nutritional composition containing the composite peptide and the probiotics provided by the invention can be completely absorbed, the survival rate of the probiotics is high, the bacterial balance in intestinal tract can be adjusted, and the intestinal tract is improvedSub-health state, and enhancing immunity. Meanwhile, the nutritional composition containing the compound peptide and the probiotics provided by the invention can supplement vitamin B5Vitamin B6Essential mineral substances and trace elements of human bodies such as vitamin C and iron elements, rich fruit flavor, fragrant and sweet taste and good acceptability.
Description
Technical Field
The invention belongs to the technical field of food processing, and particularly relates to a nutritional composition containing composite peptide and probiotics and a preparation method thereof.
Background
Peptides are formed by the condensation of the amino group of one amino acid and the carboxyl group of another amino acid, are called peptide bonds in protein chemistry, are amphiphilic compounds, and are biologically active substances involved in various cellular functions in the organism. Macroscopically, peptides play a key role in the processes of growth and development, newcastle disease, aging and death of human beings, and if the human bodies lack the peptides, the skills of the human bodies are changed greatly, and the growth and development of the children become slow or even stop. Microscopically, the peptide can regulate the balance of water and electrolyte in vivo, produce antibodies for resisting bacteria and infection for an immune system, improve immunity, promote wound healing, repair cells, improve cell metabolism and prevent cell degeneration.
Probiotics is a kind of active microorganisms beneficial to a host, and is a general term for active beneficial microorganisms which are planted in the intestinal tract and the reproductive system of a human body and can generate definite health efficacy so as to improve the micro-ecological balance of the host and play beneficial roles. The probiotics have the functions of preventing constipation, improving intestinal functions, helping digestion and absorption of nutrient substances and producing a plurality of important nutrient substances including pantothenic acid, nicotinic acid, vitamin B1, vitamin B2, vitamin B6, vitamin K and the like.
In children and the elderly, due to the development of imperfect physiological structures and functions and the deterioration of functions, the children and the elderly are more susceptible to adverse effects caused by environmental pathogens and antibiotics, and the resistance to certain diseases needs to be improved by means of external immune preparations. Therefore, it is important to develop a micro-ecological food which is convenient to drink, rich in nutrition and capable of enhancing immunity.
Patent publication No. CN105641209A discloses a probiotic composition for improving immunity, which comprises probiotic dry powder, radix astragali extract powder, fructus Lycii extract powder, and vitamin K and vitamin B12Pyridoxine, biotin, folic acid, nicotinic acid and thiamine, and is prepared from traditional Chinese medicines and probioticsThe bacteria are reasonably compatible and act synergistically, so that the immunity is remarkably improved, and the health of the organism is promoted. However, the traditional Chinese medicine components are complex, the components which inactivate probiotics are inevitably present to reduce the curative effect, and the traditional Chinese medicine is bitter in taste and generally unacceptable. Patent publication No. CN109123269A discloses a blueberry selenium peptide liquid and a preparation method thereof, wherein the formula components of the blueberry selenium peptide liquid comprise blueberry juice or blueberry fermentation product, protein peptide, maltitol, inulin, sucralose, organic selenium and the like, the peptide liquid can supplement peptide and selenium to a certain extent, but the formula components of the blueberry selenium peptide liquid do not contain substances for promoting absorption, and the peptide is not completely absorbed, so that the beneficial effect is not obvious.
In summary, the prior art generally has the technical defects of probiotic inactivation, incomplete peptide absorption, single taste, poor acceptability and the like.
Disclosure of Invention
In order to overcome the disadvantages of the prior art, the present invention aims to provide a nutritional composition containing a composite peptide and probiotics and a preparation method thereof. The peptide in the nutritional composition containing the composite peptide and the probiotics provided by the invention can be completely absorbed, the survival rate of the probiotics is high, the fruit flavor is rich, the taste is fragrant and sweet, the acceptability is good, and the immunity of the organism can be improved.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a nutritional composition containing composite peptide and probiotics comprises the following components in parts by weight:
20-30 parts of compound peptide, 10-16 parts of probiotics, 25-33 parts of fruit juice, 5-9 parts of hawthorn powder, 10-20 parts of prebiotics and vitamin B51-5 parts of vitamin B61-5 parts of maltitol, 10-20 parts of thickening agent, 5-8 parts of resveratrol and 40-50 parts of water.
Further, the nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
Furthermore, the composite peptide in the nutritional composition containing the composite peptide and the probiotics consists of marine protein peptide, marine collagen peptide and bone collagen peptide according to the weight ratio of 15-17:5-8: 9-11.
Furthermore, the probiotics in the nutritional composition containing the composite peptide and the probiotics consist of bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 16-19:13-15: 21-23.
Further, the fruit juice in the nutritional composition containing the composite peptide and the probiotics consists of apple juice, cherry juice, pomegranate juice and grapefruit juice according to the mass ratio of 9:11:7: 15.
Furthermore, the prebiotics in the nutritional composition containing the composite peptide and the probiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 13-15:2-7: 8-11.
Furthermore, the thickening agent in the nutritional composition containing the compound peptide and the probiotics consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 8-11:5-7: 3-5.
The invention also provides a preparation method of the nutritional composition containing the composite peptide and the probiotics, which comprises the following steps:
s1, mixing the compound peptide, the fruit juice and the hawthorn powder according to the formula ratio, and stirring for 10min at the rotation speed of 400-600rpm at 25 ℃ to obtain a mixed solution A;
s2, mixing the thickening agent with water according to the formula ratio, heating to 50-55 ℃, stirring for 15min under the condition of 500-600rpm, adding prebiotics and vitamin B5And vitamin B6Continuously stirring for 20min to obtain a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to 20 ℃, adding the mixed solution A prepared in the step S1, stirring for 10min under the conditions of 600-800rpm, adding maltitol and resveratrol, and continuously stirring for 10min to prepare a mixed solution C;
s4, performing high-temperature steam sterilization on the mixed solution C prepared in the step S3 at the sterilization temperature of 120-140 ℃ for 0.5h, then cooling to 20 ℃, adding probiotics according to the formula amount, stirring for 15min at the speed of 500-600rpm, and filling to obtain the product.
According to the formula, repeated research shows that the composite peptide consists of marine protein peptide, marine collagen peptide and ossein protein peptide according to a certain proportion, can rapidly pass through the oral cavity and the stomach of a human body, directly enters the small intestine, is absorbed by the small intestine, finally enters the blood circulation system, organs and cell tissues of the human body, and rapidly plays the physiological action and the biological function.
The fruit juice component and the hawthorn powder in the formula can adjust the taste of the nutritional composition, so that the nutritional composition has rich fruit taste, and the fruit juice contains rich dietary fibers, so that the intestinal tract movement can be promoted, harmful substances in the intestinal tract can be eliminated, and the absorption of the compound peptide is facilitated. The hawthorn powder can promote gastric secretion and increase enzyme in the stomach, thereby accelerating the absorption of the compound peptide. Apple polyphenol contained in apple juice also has the functions of resisting bacteria, protecting cardiovascular system and resisting decayed tooth, cherry juice has good iron supplementing effect, can improve anemia of children, and improve physical quality, pomegranate juice contains rich trace elements and amino acids, can achieve the functions of invigorating stomach, refreshing and enhancing appetite, and grapefruit juice can relieve dyspepsia, thereby being beneficial to full absorption of peptide.
Stachyose has obvious value-added effect on beneficial bacteria in intestinal tract, can quickly improve the internal environment of human digestive tract, regulate microecological bacteria balance, and the isomaltooligosaccharide has positive effect on the digestive system, immune system, metabolic circulation system and the like of human body, and has promotion effect on maintaining the functions of decomposition, transformation, absorption and the like of food in the digestive system, and inulin can promote the growth of beneficial bacteria in the intestinal tract, help to improve constipation and promote the absorption of trace elements. According to the invention, through researches, stachyose, isomaltooligosaccharide and inulin are mixed according to a certain proportion and then taken together with probiotics, so that the metabolism and proliferation of the probiotics can be promoted, the survival rate of the probiotics in the nutritional composition is ensured, the balance of bacteria in intestinal tracts is adjusted, and the sub-health state of the intestinal tracts is improved, thereby enhancing the immunity of organisms.
Vitamin B5And vitamin B6Is two water-soluble vitamins B, and has effects in promoting regeneration of body tissue, and producing antibodyPromoting the production of gastric acid in digestive system, maintaining potassium-sodium balance, etc. and can supplement vitamins and strengthen immunity. The thickening agent in the formula consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to a certain proportion, and has no mutual intersection effect or mutual elimination intersection effect, and has good emulsification stability.
Resveratrol is a natural plant antibody, has strong antioxidant capacity, can remove free radicals, and plays a role of a preservative in the formula of the invention. Meanwhile, due to the strong antioxidant capacity, the resveratrol also has the effects of improving immunity, resisting cancer, resisting virus, resisting aging and the like, and has positive synergistic effect by improving the immunity of a human body together with the compound peptide, the vitamin B5 and the vitamin B6.
Compared with the prior art, the nutritional composition containing the composite peptide and the probiotics and the preparation method thereof provided by the invention have the following technical advantages:
(1) the peptide in the nutritional composition containing the composite peptide and the probiotics provided by the invention can be completely absorbed, the survival rate of the probiotics is high, the bacterial balance in the intestinal tract is adjusted, and the sub-health state of the intestinal tract is improved, so that the immunity of the organism is enhanced;
(2) the nutritional composition containing the compound peptide and the probiotics provided by the invention can supplement vitamin B5Vitamin B6Essential mineral substances and trace elements of human bodies such as vitamin C and iron elements, has rich fruit flavor, fragrant and sweet taste and good acceptability, and can increase the immunity of the organism;
(3) the preparation method of the nutritional composition containing the composite peptide and the probiotics provided by the invention is simple and easy to operate, has controllable conditions and lower production cost, and is easy to realize industrial production.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. Various modifications can be made by those skilled in the art based on the basic idea of the invention, but it is within the scope of the invention as long as it does not depart from the basic idea of the invention.
In the embodiment, the fruit juice in the nutritional composition containing the composite peptide and the probiotics consists of apple juice, cherry juice, pomegranate juice and grapefruit juice according to the mass ratio of 9:11:7: 15.
Example 1A nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 20 parts of compound peptide, 10 parts of probiotics, 25 parts of fruit juice, 5 parts of hawthorn powder, 10 parts of prebiotics and vitamin B51 part of vitamin B61 part, 10 parts of maltitol, 9 parts of thickening agent, 5 parts of resveratrol and 50 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 15:8: 9; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 16:13: 21; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 13:2: 8; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 8:5: 3.
The preparation method of the nutritional composition containing the composite peptide and the probiotics comprises the following steps:
s1, mixing the compound peptide, the fruit juice and the hawthorn powder according to the formula ratio, and stirring for 10min at the rotation speed of 400rpm at 25 ℃ to obtain a mixed solution A;
s2, mixing the thickening agent with water according to the formula amount, heating to 50 ℃, stirring for 15min under the condition of 500rpm, and adding prebiotics and vitamin B5And vitamin B6Continuously stirring for 20min to obtain a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to 20 ℃, adding the mixed solution A prepared in the step S1, stirring for 10min at 600rpm, adding maltitol and resveratrol, and continuously stirring for 10min to prepare a mixed solution C;
s4, performing high-temperature steam sterilization on the mixed liquid C prepared in the step S3 at the sterilization temperature of 120 ℃ for 0.5h, cooling to 20 ℃, adding probiotics according to the formula amount, stirring for 15min at 500rpm, and filling to obtain the probiotic bacteria.
Example 2A nutritional composition comprising Complex peptides and Probiotics and method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the composite peptide and the probiotics comprises the following steps:
s1, mixing the compound peptide, the fruit juice and the hawthorn powder according to the formula ratio, and stirring for 10min at the rotation speed of 500rpm at 25 ℃ to obtain a mixed solution A;
s2, mixing the thickening agent with water according to the formula amount, heating to 53 ℃, stirring for 15min at 550rpm, adding prebiotics and vitamin B5And vitamin B6Continuously stirring for 20min to obtain a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to 20 ℃, adding the mixed solution A prepared in the step S1, stirring for 10min at 700rpm, adding maltitol and resveratrol, and continuously stirring for 10min to prepare a mixed solution C;
s4, performing high-temperature steam sterilization on the mixed liquid C prepared in the step S3 at the sterilization temperature of 130 ℃ for 0.5h, then cooling to 20 ℃, adding probiotics according to the formula amount, stirring for 15min at 550rpm, and filling to obtain the probiotic bacteria.
Example 3A nutritional composition comprising Complex peptides and Probiotics and method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 30 parts of compound peptide, 16 parts of probiotics, 33 parts of fruit juice, 9 parts of hawthorn powder, 20 parts of prebiotics and vitamin B55 portions of vitamin B65 parts of maltitol, 20 parts of thickening agent, 8 parts of resveratrol and 40 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 17:5: 11; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 19:15: 23; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 15:7: 11; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 11:7: 5.
The preparation method of the nutritional composition containing the composite peptide and the probiotics comprises the following steps:
s1, mixing the compound peptide, the fruit juice and the hawthorn powder according to the formula ratio, and stirring for 10min at the rotation speed of 600rpm at 25 ℃ to obtain a mixed solution A;
s2, mixing the thickening agent with water according to the formula amount, heating to 55 ℃, stirring for 15min under the condition of 600rpm, and adding prebiotics and vitamin B5And vitamin B6Continuously stirring for 20min to obtain a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to 20 ℃, adding the mixed solution A prepared in the step S1, stirring for 10min at 800rpm, adding maltitol and resveratrol, and continuously stirring for 10min to prepare a mixed solution C;
s4, performing high-temperature steam sterilization on the mixed liquid C prepared in the step S3 at the sterilization temperature of 140 ℃ for 0.5h, then cooling to 20 ℃, adding probiotics according to the formula amount, stirring for 15min at 600rpm, and filling to obtain the product.
Comparative example 1, a nutritional composition comprising a complex peptide and a probiotic and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics and fruits28 parts of juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 1:1: 1; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: the composite peptide in the comparative example consists of marine protein peptide, marine collagen peptide and bone collagen peptide according to the weight ratio of 1:1: 1.
Comparative example 2, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: the fruit juice in the comparative example consists of apple juice, cherry juice, pomegranate juice and grapefruit juice according to the mass ratio of 1:1:1: 1.
Comparative example 3, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: no hawthorn powder was added in this comparative example.
Comparative example 4, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: resveratrol was not added in this comparative example.
Comparative example 5, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 1:1: 1; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: in the comparative example, the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 1:1: 1.
Comparative example 6, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: no vitamin B was added to this comparative example5。
Comparative example 7, a nutritional composition comprising a Complex peptide and Probiotics and a method for preparing the same
The nutritional composition containing the compound peptide and the probiotics comprises the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
The composite peptide consists of marine protein peptide, marine collagen peptide and ossein peptide according to the weight ratio of 16:7: 10; the probiotics comprise bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 17:14: 22; the prebiotics consist of stachyose, isomaltooligosaccharide and inulin according to the mass ratio of 14:5: 9; the thickening agent consists of tamarind polysaccharide gum, sodium caseinate and guar gum according to the mass ratio of 9:6: 4.
The preparation method of the nutritional composition containing the complex peptide and the probiotics is similar to that of example 2.
The comparative example differs from example 2 in that: no vitamin B was added to this comparative example6。
Test example one, test for modulating intestinal flora with nutritional composition
Test samples: examples 1 to 3, comparative example 5, the prepared nutritional composition containing the complex peptide and the probiotic bacteria;
the test method comprises the following steps: mice adopting salmonella to construct a diarrhea model are divided into 4 groups, the groups of examples 1-3 and comparative example 5 drink the nutrient composition containing the compound peptide and the probiotics prepared in the examples 1-3 and the comparative example 5 every day, and the blank group drinks elegant purified water every day; after feeding 4 groups of mice for 30 days, observing the diarrhea condition of the mice; one day before the experiment, feces were collected and stored at-80 ℃ for intestinal flora analysis. Carrying OUT 16S rDNA high-throughput gene sequencing on the excrement of each group of mice, wherein the sequencing region is a V3-V4 region, and obtaining the OUT number of each group through sequencing;
and (3) test results: the test results are shown in Table 1.
TABLE 1 nutritional compositions for modulating the effects of intestinal flora
Group of | Whether or not diarrhea is present | Number of OUT |
Example 1 | Whether or not | 275 |
Example 2 | Whether or not | 281 |
Example 3 | Whether or not | 273 |
Comparative example 5 | Is that | 234 |
Blank group | Is that | 215 |
As can be seen from table 1, the nutritional composition containing the composite peptide and the probiotics provided by the invention has good efficacy of regulating intestinal flora, and can effectively improve diarrhea, activate gastrointestinal functions and promote intestinal health. The mice in the group of the example 2 have the highest fecal OUT number of 281, and compared with the blank group, 66 is increased, and the increment is obvious, so the example 2 is the best example of the invention. Compared with the example 2, the comparative example 5 changes the dosage ratio of the prebiotics in the formula components, but the efficacy of the prepared nutritional composition containing the compound peptide and the probiotics for regulating the intestinal flora is reduced, which shows that the dosage ratio of the prebiotics in the formula of the invention is optimized, the metabolism and proliferation of the probiotics can be promoted under the condition of the dosage ratio, the survival rate of the probiotics in the intestinal tract after the nutritional composition is drunk is ensured, the bacterial balance in the intestinal tract is regulated, and the sub-health state of the intestinal tract is improved.
Test example two, test of immunomodulating Effect of nutritional composition
Test samples: the nutritional compositions containing the complex peptide and the probiotics prepared in examples 1 to 3, comparative examples 1 to 4, and comparative examples 6 to 7;
the test method comprises the following steps: selecting 100 ICR healthy magnetic mice of 6-8 weeks provided by the Experimental animals center of the department of medicine of Beijing university, randomly dividing the ICR healthy magnetic mice into 10 groups, each group comprises 10 ICR healthy magnetic mice, the nutritional compositions containing the compound peptide and the probiotics are prepared by respectively gavage the stomach of the embodiments 1-3, the comparative examples 1-4 and the comparative examples 6-7, the blank groups are gavage with elegant purified water, the stomach is gavage for 1 time every day, each gavage is 0.1mL/10g of the weight of the mice, the animals freely eat and drink water during the experiment period, and the mice are killed to measure various indexes after the mice are gavage for 4 weeks;
determination of proliferation capacity of Con A-induced splenic lymphocytes in mice: aseptically collecting spleen, grinding, filtering (200 mesh), washing, suspending, and making into cell with cell concentration of 5 × 106Spleen cell suspension, adding the spleen cell suspension into 24-well culture plate in 2-well, each well containing 1mL of 1. mu.l Con A in experimental well and no Con A in another well as control well, and adding 5% CO2After culturing at 37 ℃ for 72 hours, the A value was measured at a wavelength of 570nm by the MTT method, and the difference between the A values of the experimental wells and the control wells was used as the valueLymphocyte competence;
and (3) test results: the test results are shown in Table 2.
Table 2 nutritional composition immunomodulating test results
As can be seen from table 2, the nutritional composition containing the composite peptide and the probiotics provided by the present invention has a good effect of enhancing immunity, and the proliferation ability of mouse lymphocytes and the swelling degree of foot metatarsal swelling induced by ConA are significantly improved compared with the blank group, wherein the proliferation ability of mouse lymphocytes and the swelling degree of foot metatarsal swelling induced by ConA of the nutritional composition containing the composite peptide and the probiotics prepared in example 2 are the most improved, which is the best example of the present invention.
Compared with example 2, comparative example 1 changed the dosage ratio of the composite peptide, but the effect of enhancing immunity of the prepared nutritional composition was reduced, which indicates that the dosage and ratio of the composite peptide in the formulation of the present invention have reached the optimal values. Comparative examples 2 and 3 change the dosage ratio and dosage of the fruit juice and the hawthorn powder, but the prepared nutritional composition has reduced effect of enhancing immunity, which indicates that the fruit juice and the hawthorn powder can promote the full absorption of the compound peptide, thereby achieving the effect of enhancing the body immunity. Comparative example 4 where resveratrol was not added, but the resulting nutritional composition had a reduced effect on enhancing immunity, indicating that resveratrol, while acting as a preservative, may also act in combination with a complex peptide and vitamin B5Vitamin B6Has synergistic effect and can improve immunity. In comparative example 6 and comparative example 7, no vitamin B was added5Vitamin B6However, the resulting nutritional composition has a reduced effect on enhancing immunity, which indicates that vitamin B is present5Vitamin B6Can supplement vitamins and enhance immunity.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art will recognize that changes may be made to the embodiments described above without departing from the spirit and scope of the invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the technical spirit of the present invention are covered by the claims of the present invention.
Claims (8)
1. The nutritional composition containing the composite peptide and the probiotics is characterized by comprising the following components in parts by weight:
20-30 parts of compound peptide, 10-16 parts of probiotics, 25-33 parts of fruit juice, 5-9 parts of hawthorn powder, 10-20 parts of prebiotics and vitamin B51-5 parts of vitamin B61-5 parts of maltitol, 10-20 parts of thickening agent, 5-8 parts of resveratrol and 40-50 parts of water.
2. The nutritional composition containing the composite peptide and the probiotics according to claim 1, which is characterized by comprising the following components in parts by weight: 26 parts of compound peptide, 14 parts of probiotics, 28 parts of fruit juice, 7 parts of hawthorn powder, 16 parts of prebiotics and vitamin B53 portions of vitamin B64 parts of maltitol, 15 parts of thickening agent, 6 parts of resveratrol and 48 parts of water.
3. The nutritional composition according to claim 1 or 2, wherein the complex peptide consists of marine protein peptide, marine collagen peptide and bone collagen peptide in a weight ratio of 15-17:5-8: 9-11.
4. The nutritional composition containing the complex peptide and the probiotics according to claim 1 or 2, wherein the probiotics consist of bifidobacterium ovorans, lactobacillus casei and streptococcus thermophilus according to the mass ratio of 16-19:13-15: 21-23.
5. The nutritional composition containing the complex peptides and the probiotics according to claim 1 or 2, wherein the fruit juice consists of apple juice, cherry juice, pomegranate juice and grapefruit juice in a mass ratio of 9:11:7: 15.
6. The nutritional composition containing the complex peptide and the probiotics as claimed in claim 1 or 2, wherein the prebiotics comprise stachyose, isomaltooligosaccharide and inulin at a mass ratio of 13-15:2-7: 8-11.
7. The nutritional composition containing the complex peptide and the probiotics as claimed in claim 1 or 2, wherein the thickener consists of tamarind polysaccharide gum, sodium caseinate and guar gum in a mass ratio of 8-11:5-7: 3-5.
8. A method for preparing a nutritional composition comprising a complex peptide and a probiotic according to any of claims 1 to 7, comprising the steps of:
s1, mixing the compound peptide, the fruit juice and the hawthorn powder according to the formula ratio, and stirring for 10min at the rotation speed of 400-600rpm at 25 ℃ to obtain a mixed solution A;
s2, mixing the thickening agent with water according to the formula ratio, heating to 50-55 ℃, stirring for 15min under the condition of 500-600rpm, adding prebiotics and vitamin B5And vitamin B6Continuously stirring for 20min to obtain a mixed solution B;
s3, cooling the mixed solution B prepared in the step S2 to 20 ℃, adding the mixed solution A prepared in the step S1, stirring for 10min under the conditions of 600-800rpm, adding maltitol and resveratrol, and continuously stirring for 10min to prepare a mixed solution C;
s4, performing high-temperature steam sterilization on the mixed solution C prepared in the step S3 at the sterilization temperature of 120-140 ℃ for 0.5h, then cooling to 20 ℃, adding probiotics according to the formula amount, stirring for 15min at the speed of 500-600rpm, and filling to obtain the product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011473752.1A CN112704234A (en) | 2020-12-15 | 2020-12-15 | Nutritional composition containing composite peptide and probiotics and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202011473752.1A CN112704234A (en) | 2020-12-15 | 2020-12-15 | Nutritional composition containing composite peptide and probiotics and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112704234A true CN112704234A (en) | 2021-04-27 |
Family
ID=75542027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202011473752.1A Pending CN112704234A (en) | 2020-12-15 | 2020-12-15 | Nutritional composition containing composite peptide and probiotics and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112704234A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115349634A (en) * | 2022-08-26 | 2022-11-18 | 海南华研胶原科技股份有限公司 | Probiotic composite powder containing walnut peptide and preparation method thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040161422A1 (en) * | 1999-04-30 | 2004-08-19 | Natarajan Ranganathan | Nutritional compositions comprising probiotics |
CN108142770A (en) * | 2017-12-18 | 2018-06-12 | 沈阳润东生物科技有限公司 | A kind of polynary probiotics solid beverage of breast peptide |
CN109287920A (en) * | 2018-09-14 | 2019-02-01 | 安吉艾格赛思生物科技有限公司 | A kind of solid beverage and preparation method thereof of multicomponent complex and multi-joint probiotics |
CN109288063A (en) * | 2018-09-14 | 2019-02-01 | 安吉艾格赛思生物科技有限公司 | A kind of multi-joint Cernevit-12 and preparation method thereof being proliferated beneficial bacteria of intestinal tract |
CN109907262A (en) * | 2019-03-28 | 2019-06-21 | 广东时代食品与生命健康研究有限公司 | A kind of probiotic composition |
CN111109492A (en) * | 2020-01-14 | 2020-05-08 | 上海昊岳食品科技有限公司 | Functional collagen peptide probiotic solid beverage and preparation method thereof |
-
2020
- 2020-12-15 CN CN202011473752.1A patent/CN112704234A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040161422A1 (en) * | 1999-04-30 | 2004-08-19 | Natarajan Ranganathan | Nutritional compositions comprising probiotics |
CN108142770A (en) * | 2017-12-18 | 2018-06-12 | 沈阳润东生物科技有限公司 | A kind of polynary probiotics solid beverage of breast peptide |
CN109287920A (en) * | 2018-09-14 | 2019-02-01 | 安吉艾格赛思生物科技有限公司 | A kind of solid beverage and preparation method thereof of multicomponent complex and multi-joint probiotics |
CN109288063A (en) * | 2018-09-14 | 2019-02-01 | 安吉艾格赛思生物科技有限公司 | A kind of multi-joint Cernevit-12 and preparation method thereof being proliferated beneficial bacteria of intestinal tract |
CN109907262A (en) * | 2019-03-28 | 2019-06-21 | 广东时代食品与生命健康研究有限公司 | A kind of probiotic composition |
CN111109492A (en) * | 2020-01-14 | 2020-05-08 | 上海昊岳食品科技有限公司 | Functional collagen peptide probiotic solid beverage and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
刘心宇: "《谁偷了你的健康》", 30 April 2008, 崇文书局 * |
马华强: "《常见中草药应用图册》", 31 January 2019, 福建科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115349634A (en) * | 2022-08-26 | 2022-11-18 | 海南华研胶原科技股份有限公司 | Probiotic composite powder containing walnut peptide and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105146614B (en) | A kind of functional calcium fruit ferment, enzyme beverage and its production method | |
CN108812909B (en) | Complementary food nutritional supplement for improving monophagia or anorexia and preparation method thereof | |
CN104758318B (en) | A kind of compound formulation and preparation method thereof reducing diarrhea of weaned piglets rate | |
CN110179121A (en) | It is a kind of to improve the 5-linked probiotic composition of enteron aisle, compound solid beverage and its preparation method and application | |
CN108783431A (en) | A kind of fruit ferment and preparation method thereof | |
CN108041169A (en) | A kind of children's solid beverage containing probiotics and prebiotics and preparation method thereof | |
CN108244252A (en) | Probiotics multielement protein powder and preparation method thereof | |
CN110338402A (en) | A kind of compound probiotic powder and preparation method thereof | |
CN106889414A (en) | Double bacterium solid hawthorn beverages | |
CN112056399A (en) | Probiotic composition for enhancing immunity and application thereof | |
CN102524539B (en) | Animal health preserver composition and preparation process for animal health preserver composition | |
CN108913639A (en) | A kind of Lactobacillus rhamnosus complexing agent and its preparation method and application | |
CN106343022A (en) | Health-care yoghurt with helicobacter pylori inhibiting effect and production method of health-care yoghurt | |
CN102742653B (en) | Brain-strengthening and nerve soothing probiotic goat milk tablet and preparation method of brain-strengthening and nerve soothing probiotic goat milk tablet | |
CN108669563A (en) | A kind of composition, its application and strengthen immunity, the product for improving allergy | |
CN108936628A (en) | A kind of specific full nutritional formulas and preparation method thereof that patients with cerebral apoplexy is edible | |
CN110200186B (en) | Probiotic solid beverage and preparation method thereof | |
CN105802876B (en) | A kind of composite probiotics ferment clover tender shoots powder preparation and its preparation method and application | |
CN108795823A (en) | It is a kind of improve women pregnant and lying-in women's intestinal flora probiotics cultural method and application | |
CN112704234A (en) | Nutritional composition containing composite peptide and probiotics and preparation method thereof | |
CN110313599A (en) | A kind of anti-trioxypurine jelly and preparation method thereof | |
CN1305383C (en) | Active bifidobacteria contained milk powder and its preparation method | |
CN104256656A (en) | Full-nutrition formulated food for fatty acid metabolic disorder | |
US20230227771A1 (en) | Pre-conditioning of l.reuteri | |
CN108782963A (en) | It is a kind of can antibacterial improve immunity probiotics and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210427 |