CN112691130B

CN112691130B - Application of herba Aristolochiae rotundus and its extract in preparing medicine for treating gastrointestinal diseases and its pharmaceutical formulation

Info

Publication number: CN112691130B
Application number: CN202110172782.7A
Authority: CN
Inventors: 李文芳
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-02-08
Filing date: 2021-02-08
Publication date: 2022-06-17
Anticipated expiration: 2041-02-08
Also published as: CN112691130A

Abstract

The invention discloses application of cyclocarya paliurus and an extract thereof in preparing a medicine for treating gastrointestinal diseases and a medicine formula, wherein the medicine formula contains the cyclocarya paliurus or the extract thereof, and the medicine formula also contains Yunnan white-drug-one-mouth handleless cup; the traditional Chinese medicine composition has a special effect on diminishing inflammation and sterilizing helicobacter pylori, effectively inhibits bacterial infection, prevents helicobacter pylori from spreading in a human body, can quickly treat gastric diseases such as gastric ulcer, antral gastritis, chronic gastritis and gastrectasia, and has a special curative effect on constipation caused by ulcerative colitis.

Description

Application of herba Aristolochiae rotundus and its extract in preparing medicine for treating gastrointestinal diseases and its pharmaceutical formulation

Technical Field

The invention relates to the technical field of medicines, in particular to application of arthrobotrys rotundifolia and an extract thereof in preparing a medicine for treating helicobacter pylori and gastrointestinal diseases and a medicine formula thereof.

Background

The stomach is primarily the place where the body will help digest and grind food, including storing food. Gastrointestinal disorders refer to disorders of the stomach. In China, the proportion of patients with gastrointestinal diseases is very high, the main symptoms of the gastrointestinal diseases comprise abdominal stomach and wrist discomfort, pain, postprandial distention, eructation, acid regurgitation, nausea, vomiting and the like, and the clinically common gastrointestinal diseases comprise acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, gastroduodenal complex ulcer, gastric polyp, gastric calculus, benign and malignant tumors of stomach, prolapse of gastric mucosa, acute gastric dilatation, pyloric obstruction and the like. At present, more western medicines and medicines are used for treating gastrointestinal diseases, such as acid-resistant medicines, and are used for neutralizing and inhibiting gastric acid secretion, so that the gastric acidity is reduced, the activity of pepsin is inhibited, and the attack factor of the stomach is reduced. Such drugs as Weishuping, Weibizhi, Weidele, etc.; secondly, the gastric mucosa is protected to combine with pepsin to inhibit the protease from decomposing protein, and can be combined with the protein of the gastric mucosa to form a protective covering ulcer surface, which is beneficial to mucosa regeneration and promotes ulcer healing. Such drugs as gastrodin, sucralfate, colloidal bismuth, etc.; antibiotics for killing helicobacter pylori, promoting HP to turn negative and benefiting improvement of chronic gastritis, such as metronidazole, colloidal bismuth, tetracycline and the like. The Chinese patent medicine has the functions of diminishing inflammation, relieving pain, promoting qi circulation and invigorating stomach, and is prepared by the following raw materials: promoting digestion, relieving flatulence, promoting qi circulation, and relieving pain, such as radix aucklandiae pill, pill for relieving chest stuffiness and diaphragm, and WEIFU granule; warming middle-jiao and regulating stomach, promoting qi circulation and resolving stagnation, such as XIANGSHAYANGWEI pill, BUPIYICHANG pill, etc.; inhibiting acid, relieving pain, and promoting gastric mucosa regeneration such as WEIKANG Capsule; although the curative effect of the traditional Chinese medicine and western medicine at present has the effects of controlling the illness state and healing, the recurrence rate is high, the radical treatment effect is not obvious, but the western medicine generally has the defects of large side effect (rash, hypotension, nausea, vomit, dizziness, hypoglycemia and the like), high price and many contraindications; most of the medicines have complex compositions, and part of the raw materials are difficult to purchase in the market, so the medicine has low cure rate, easy relapse after recovery, unobvious curative effect and long treatment course. The herba Oenotherae Erythrosepalae is a plant of Oenothera of Lythraceae, and the whole herb can be used as medicine, and has medicinal value: sweet in taste; diluting; is cool in nature. Meridian tropism: the liver and kidney meridians. Can dissipate blood stasis and stop bleeding; eliminating dampness and removing toxic substance. Mainly treating traumatic injury; bleeding due to internal and external injury; (ii) a bone fracture; rheumatic arthralgia; snake bite; carbuncle sore and pyogenic infections; scabies; dysentery; gonorrhea; water tympany; acute hepatitis; carbuncle, swelling and sore; swelling and aching of gum; hemorrhoids; acute mastitis; acute meningitis; acute pharyngolaryngitis; menoxenia; dysmenorrhea; scald and burn; the herbal and wood formula records that all the herbs are toxic to fire and can promote diuresis, clear heat, relieve carbuncle and swelling and remove heat-toxin. It is indicated for stranguria, dysentery and hemorrhoid due to fire and damp invasion of decoction. The book Guiyang folk herb is loaded with the medicine for treating cough and water-borne diseases. "(the four Chuan Zhi Shi): clearing away heat and toxic material, relaxing the bowels and relieving swelling. It is indicated for swelling and pain of gum, abscess and toxicity. ".

Disclosure of Invention

The invention aims to provide the application of the ardisia pusilla and the extractive thereof in preparing the medicine for treating the gastrointestinal diseases (helicobacter pylori) and the medicine formula thereof, and the formula can be orally taken without obvious toxic and side effects.

In order to achieve the purpose, the technical scheme adopted by the invention for solving the technical problem is as follows:

use of herba Arthropodae Repentis and its extract in preparing medicine for treating gastrointestinal diseases, such as gastrointestinal diseases caused by helicobacter pylori, gastric ulcer, antral gastritis, chronic gastritis, gastrectasia, and constipation caused by ulcerative colitis is provided.

Preferably, the extract comprises liquid or solid obtained by ethanol extraction or water extraction of the burclover and a mixture thereof, wherein the ethanol extraction comprises ethanol extraction, the burclover is crushed and then added with ethanol for low-temperature crushing at 0-4 ℃, the ethanol concentration is 50-75 percent by mass, the liquid is filtered after extraction for ethanol removal, so that the extract is obtained, and the extract can also be dried to obtain the solid; secondly, water extraction comprises the steps of placing the burclover into water, homogenizing and crushing the burclover at high speed at 0-5 ℃ by a homogenizer, boiling extracted liquid, and performing rotary volatilization on the liquid to obtain liquid or solid; the mixture comprises the mixture of extracts obtained by alcohol extraction and water extraction.

A pharmaceutical formulation for treating helicobacter pylori, gastrointestinal diseases, said pharmaceutical formulation comprising Arthropoda rotundifolia or an extract thereof.

Preferably, the medicine formula also comprises a handless cup, has the functions of dispelling wind and dissipating heat, inhibiting bacteria and diminishing inflammation, and preventing corrosion and relieving itching, and is used for preventing influenza and epidemic cerebrospinal meningitis and treating upper respiratory tract infection, sphagitis, bronchitis and pneumonia; it can be used for treating burn, scald, and cellulitis. The addition of fructus Eucalypti Robustae can improve the therapeutic effect of gastric ulcer and helicobacter pylori, and shorten the treatment course.

Preferably, the weight percentage of the ardisia crenata sims or the extract thereof in the pharmaceutical formula is m, 0% < m < 100%, wherein the content of the preferred content of the ardisia crenata sims is 5-100g, and the therapeutic effect on constipation, helicobacter pylori, antral gastritis and chronic gastritis caused by ulcerative colitis can be obviously improved without relapse.

Preferably, the mass fraction ratio of the leaf of round leaf burclover or the extract thereof to the herba cistanches in the medicinal formula is 1: 0.01-0.5.

Preferably, the pharmaceutical formulation can be made into raw slices, tablets, pills, capsules, suspensions, aqueous solutions, powders or emulsions.

The invention has the following beneficial effects:

the invention can quickly treat stomach diseases such as helicobacter pylori sterilization, gastric ulcer, antral gastritis, gastrectasia, chronic gastritis and the like, has special effect and special curative effect on constipation caused by ulcerative colitis, has special effect on the helicobacter pylori anti-inflammation sterilization, effectively inhibits bacterial infection, and prevents helicobacter pylori from spreading in human body from the source, and has low cost, quick effect, cure rate of more than 90 percent and small recurrence possibility.

Detailed Description

The present invention is further described in detail with reference to specific examples, so that those skilled in the art can implement the invention with reference to the description.

The materials used in the examples were all purchased at a pharmacy.

Example 1

Weighing dried Arthropoda stolonifera 5g, adding 400ml water, decocting to 100ml, filtering, and collecting liquid.

Example 2

Weighing 20g of dried Arthropoda stolonifera, adding 400ml of water, boiling to 100ml, and filtering to obtain liquid.

Example 3

Weighing 35g of dried Arthropoda stolonifera, adding 400ml of water, boiling to 100ml, and filtering to obtain liquid.

Example 4

Weighing 50g of dried Arthropoda stolonifera, adding 400ml of water, boiling to 100ml, and filtering to obtain liquid.

Example 5

Weighing 65g of dried Arthropoda stolonifera, adding 600ml of water, cooking to 100ml, and filtering to obtain liquid.

Example 6

Weighing 80g of dried Arthropoda stolonifera, adding 600ml of water, cooking to 100ml, and filtering to obtain liquid.

Example 7

Weighing dried Arthropoda stolonifera 95g, adding 600ml water, decocting to 100ml, filtering, and collecting liquid.

Example 8

Weighing 100g of dried Arthropoda stolonifera, adding 600ml of water, cooking to 100ml, and filtering to obtain liquid.

Example 9

The leaf of Odontoglossum was not dried as in example 2.

Example 10

Weighing dried leaf of Arthropoda japonica 20g, adding fructus Eucalypti Robustae 0.2g, adding 400ml water, decocting to 100ml, filtering, and collecting liquid.

Example 11

Weighing dried herba Pileae Scriptae 20g, fructus Eucalypti Robustae 10g, adding 400ml water, decocting to 100ml, filtering, and collecting liquid.

Example 12

Weighing dried Arthropoda stolonifera 20g and handless cup 5g, adding 400ml of water, decocting to 100ml, filtering, and collecting liquid.

Example 13

Weighing 20g of dried Arthropoda rotundifolia, crushing into powder, adding an auxiliary material medicinal binder, and making into tablets.

Example 14

Weighing 20g of dried cyclocarya paliurus and 5g of herba Lobeliae chinensis, weighing 20g of dried cyclocarya paliurus, pulverizing into powder, adding adjuvant medicinal binder, and making into tablet.

Toxicity test was performed: the mice of examples 1-14 were tested, the mice were adult mice weighing 40-50g, the mice were divided into 43 groups, 42 groups were tested, 1 group was blank control group, each group had 5 mice, the drug feeding test was carried out three times a day with a dose of 2ml/kg,10ml/kg, and 20ml/kg (human recommended dose 100ml/50 kg-2 ml/kg) respectively 1, 5, and 10 times the human recommended dose, the drug feeding was carried out, the drug feeding was stopped half a year and the observation test was carried out half a year later, no toxicity symptoms were observed after the drug feeding, and the normal activity of the mice half a year later was observed.

Case 1, plum, 40 years old at one year, chronic antral gastritis for 5 years, was administered according to the prescription of example 2 three times a day, 14 days without drug withdrawal, with disappearance of gastritis symptoms and no recurrence symptoms after 2 years.

Case 2, 26 years old in Wangzhong years, was positive in C14 test of H.pylori, and was administered according to the prescription of example 2 three times a day, 14 days after drug withdrawal, and negative in C14 test one month later.

Case 3, wu, 65 years old, gastric ulcer 10 years old, was taken three times a day, 14 days discontinued, gastric ulcer symptoms disappeared, and no recurrence symptoms occurred after 5 years, according to the prescription of example 11.

Case 4, the constipation of the polygonum of 36 years old in certain age, caused by ulcerative colitis, was taken three times a day according to the prescription of example 3, the constipation was significantly improved on day 3 after the administration, the constipation symptom disappeared on day 7, the stool was normal, the administration was stopped on day 14, and no constipation symptom was observed for half a year.

According to the statistics of the inventor data, the cure rate of the invention reaches more than 90 percent, and the symptoms of the patient can be quickly relieved and cured.

The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims.

Claims

1. An application of the extract of the leaf of Chinese violet herb in preparing the medicine for treating the gastrosis caused by pylorus helicobacterium is disclosed.