CN113663024A - Traditional Chinese medicine composition for treating viral myocarditis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating viral myocarditis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating viral myocarditis and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating viral myocarditis comprises the following raw materials in parts by weight: 5-15 parts of fructus forsythiae, 3-8 parts of cassia twig, 5-8 parts of radix stephaniae tetrandrae, 8-15 parts of radix ophiopogonis, 5-10 parts of calyx kaki, 8-10 parts of radix rubiae and 5-10 parts of radix cannabis; it can effectively relieve and treat related symptoms caused by viral myocarditis, and can effectively control diseases to cure patients. The preparation method comprises the following steps: pulverizing the raw materials, adding ethanol, refluxing and leaching twice, filtering, and recovering ethanol to obtain leaching solution and residue; adding water into the residues, decocting, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating into extract, drying, and pulverizing to obtain the final product; the method has simple process, and the prepared product has good therapeutic effect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating viral myocarditis and a preparation method thereof.
Background
Viral myocarditis refers to myocardial local or diffuse acute or chronic inflammatory diseases caused by viral infection, belongs to infectious myocardial diseases, and multiple viruses can cause myocarditis, wherein viral infection causing intestinal tract and upper respiratory tract infection is the most common, clinical manifestations are slightly different, mild patients can have no symptoms, severe patients can have heart failure, cardiogenic shock and sudden death, and serious threats are caused to daily life and life health of patients.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating viral myocarditis, which can effectively relieve and treat related symptoms caused by viral myocarditis, and can effectively control diseases to cure patients.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating viral myocarditis, which is simple in process and good in treatment effect of the prepared product.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the invention provides a traditional Chinese medicine composition for treating viral myocarditis, which comprises the following raw materials in parts by weight: 5-15 parts of fructus forsythiae, 3-8 parts of cassia twig, 5-8 parts of radix stephaniae tetrandrae, 8-15 parts of radix ophiopogonis, 5-10 parts of calyx kaki, 8-10 parts of radix rubiae and 5-10 parts of radix linderae.
On the other hand, the embodiment of the invention provides a preparation method of a traditional Chinese medicine composition for treating viral myocarditis, which comprises the following steps: pulverizing fructus forsythiae, ramulus Cinnamomi, radix Stephaniae Tetrandrae, radix Ophiopogonis, calyx kaki, radix Rubiae and radix Seu folium Cayratiae Japonicae, adding ethanol, reflux extracting for two times, filtering, and recovering ethanol to obtain extractive solution and residue; adding water into the residues, decocting, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract, drying, and pulverizing to obtain the final product.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
aiming at the first aspect, the embodiment of the invention provides a traditional Chinese medicine composition for treating viral myocarditis, which comprises the following raw materials in parts by weight: 5-15 parts of fructus forsythiae, 3-8 parts of cassia twig, 5-8 parts of radix stephaniae tetrandrae, 8-15 parts of radix ophiopogonis, 5-10 parts of calyx kaki, 8-10 parts of radix rubiae and 5-10 parts of radix linderae.
In the above examples, the effects of the raw materials are as follows:
fructus forsythiae: clearing away heat and toxic materials, relieving swelling, and dispersing pathogen accumulation; can be used for treating carbuncle, cellulitis, scrofula, acute mastitis, erysipelas, wind-heat type common cold, early epidemic febrile disease, warm heat entering nutrient system, hyperpyrexia, polydipsia, coma, stranguria, and anuresis;
cassia twig: inducing sweat to relieve muscles, warming and dredging channels, supporting yang to transform qi, and calming the adverse-rising energy; can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping;
stephania tetrandra: induce diuresis to alleviate edema, dispel wind to alleviate pain; can be used for treating edema, tinea pedis, dysuresia, eczema, skin sore, rheumatalgia, and hypertension;
and (3) dwarf lilyturf root: nourishing yin and moistening lung, clearing away heart-fire and relieving restlessness, benefiting stomach and promoting fluid production; treating dry cough due to lung dryness, hematemesis, hemoptysis, consumptive lung disease, pulmonary abscess, consumptive disease with dysphoria, thirst, heat disease with body fluid consumption, dry throat and mouth, and constipation;
persimmon calyx: descending adverse qi; arresting hiccup and vomiturition;
sea madder: softening and resolving hard mass, clearing heat and eliminating phlegm, and inducing diuresis; scrofula, goiter, sore throat, cough, phlegm accumulation, dysuria, edema, sore, furuncle, angina pectoris, iodine deficiency type endemic goiter, hypertension and hyperlipemia;
and (3) wild hemp: dispelling wind, relieving cough, and removing dampness; it is mainly used for treating cold, cough, dysentery, and skin eczema.
According to the traditional Chinese medicine composition for treating viral myocarditis, in the raw material medicinal materials, the fructus forsythiae contains a plurality of substances such as phillyrin, forsythin and oleanolic acid, and has an inhibiting effect on a plurality of bacteria and fungi such as staphylococcus aureus, pneumococcus, streptococcus A and B, catarrhal coccus, shigella flexneri, paratyphoid bacillus A, escherichia coli, and pneumobacillus, and also has an inhibiting and resisting effect on viruses, so that fever, pharyngalgia and other symptoms similar to cold in the early stage of viral myocarditis can be treated, and the detoxifying effect is achieved; the cassia twig contains various components such as cinnamaldehyde, benzyl benzoate, calamus alkene and the like, has the effect of inhibiting and resisting various bacteria such as staphylococcus albus, shigella, typhoid and paratyphoid bacillus, pneumococcus, aerobacter, proteus, bacillus anthracis, salmonella enteritidis, vibrio cholerae and the like and various viruses such as influenza virus and the like, also has the effect of diuresis, and can relieve and treat symptoms such as chest stuffiness, palpitation and the like; the stephania tetrandra contains multiple substances such as tetrandrine, flavonoid glycoside and the like, can effectively play roles in diminishing inflammation, easing pain, clearing heat and resisting allergy, can also inhibit the generation of anaphylactic shock symptoms, and simultaneously has the effects of resisting bacteria, protozoans and tumors; the ophiopogon contains various glucoside substances, can effectively prevent and resist arrhythmia symptoms, can improve the immunity of the organism, has the effects of strengthening heart, calming, resisting fatigue and the like, can relieve and treat arrhythmia and other symptoms caused by viral myocarditis, and can repair damaged cardiac muscle cells; the calyx kaki contains oleanolic acid, betulinic acid, quercetin, etc., and can be used for treating emesis, regurgitation, arrhythmia, and viral myocarditis; the sea madder contains alginic acid, mannitol and other substances, has the effects of resisting tumor, blood coagulation and infection, has positive effects on cardiovascular systems, can relieve and treat angina, myocardial necrosis and other diseases, and can also treat symptoms such as angina, fever and the like; the fructus cannabis contains various substances such as ursolic acid, jute diglucoside, jute glucoside and the like, can effectively play a role in strengthening, can inhibit and treat symptoms such as heart failure, arrhythmia and the like, has high effect taking speed and good treatment effect, and can treat symptoms such as cold, cough and the like. The raw material medicines are matched with each other, have synergistic interaction, can effectively inhibit various pathogenic microorganisms such as bacteria, fungi, viruses and the like, have the effects of resisting infection and diminishing inflammation, can effectively relieve and treat symptoms such as fever, cough, vomiting, palpitation, heart rate disorder, heart failure and the like caused by viral myocarditis, and have good treatment effect.
Aiming at the second aspect, the embodiment of the invention provides a preparation method of a traditional Chinese medicine composition for treating viral myocarditis, which comprises the following steps: pulverizing fructus forsythiae, ramulus Cinnamomi, radix Stephaniae Tetrandrae, radix Ophiopogonis, calyx kaki, radix Rubiae and radix Seu folium Cayratiae Japonicae, adding ethanol, reflux extracting for two times, filtering, and recovering ethanol to obtain extractive solution and residue; adding water into the residues, decocting, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract, drying, and pulverizing to obtain the final product.
According to the preparation method of the traditional Chinese medicine composition for treating viral myocarditis, fructus forsythiae, cassia twig, radix stephaniae tetrandrae, radix ophiopogonis, calyx kaki, radix rubiae and radix cannabis are firstly crushed, so that beneficial ingredients in raw medicinal materials can be more fully extracted in the subsequent steps, and the curative effect of a product medicine is improved; then adding ethanol into the crushed medicinal materials, carrying out reflux extraction, adding water into obtained decoction dregs for decoction, combining the two extraction means of reflux extraction and decoction, and extracting beneficial components in the medicinal materials more fully, so that the medicinal materials can be better combined and matched with each other, the synergistic effect is realized, the waste loss is avoided, and the medicinal effect and the quality of the product are further improved; mixing the leaching solution and the decoction, concentrating to obtain extract, and concentrating to further increase the concentration of the medicine and enhance the curative effect; and finally, drying and crushing to prepare a finished product, so that different formulations such as granules, tablets and the like can be conveniently prepared and the finished product is convenient to use. The whole preparation method has simple flow, and the prepared product has good curative effect and convenient and quick use.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the invention provides a traditional Chinese medicine composition for treating viral myocarditis, which comprises the following raw materials in parts by weight: 5-15 parts of fructus forsythiae, 3-8 parts of cassia twig, 5-8 parts of radix stephaniae tetrandrae, 8-15 parts of radix ophiopogonis, 5-10 parts of calyx kaki, 8-10 parts of radix rubiae and 5-10 parts of radix linderae.
In the above embodiments, the fructus forsythiae contains various substances such as forsythin, oleanolic acid and the like, and has inhibitory effects on various bacteria and fungi such as staphylococcus aureus, pneumococcus, streptococcus A, streptococcus B, catarrh coccus, shigella flexneri, paratyphoid a bacillus, escherichia coli, pneumobacillus and the like, and also has inhibitory and resistant effects on viruses, so that fever, pharyngalgia and other symptoms similar to cold in the early stage of viral myocarditis can be treated, and the detoxifying effect is achieved; the cassia twig contains various components such as cinnamaldehyde, benzyl benzoate, calamus alkene and the like, has the effect of inhibiting and resisting various bacteria such as staphylococcus albus, shigella, typhoid and paratyphoid bacillus, pneumococcus, aerobacter, proteus, bacillus anthracis, salmonella enteritidis, vibrio cholerae and the like and various viruses such as influenza virus and the like, also has the effect of diuresis, and can relieve and treat symptoms such as chest stuffiness, palpitation and the like; the stephania tetrandra contains multiple substances such as tetrandrine, flavonoid glycoside and the like, can effectively play roles in diminishing inflammation, easing pain, clearing heat and resisting allergy, can also inhibit the generation of anaphylactic shock symptoms, and simultaneously has the effects of resisting bacteria, protozoans and tumors; the ophiopogon contains various glucoside substances, can effectively prevent and resist arrhythmia symptoms, can improve the immunity of the organism, has the effects of strengthening heart, calming, resisting fatigue and the like, can relieve and treat arrhythmia and other symptoms caused by viral myocarditis, and can repair damaged cardiac muscle cells; the calyx kaki contains oleanolic acid, betulinic acid, quercetin, etc., and can be used for treating emesis, regurgitation, arrhythmia, and viral myocarditis; the sea madder contains alginic acid, mannitol and other substances, has the effects of resisting tumor, blood coagulation and infection, has positive effects on cardiovascular systems, can relieve and treat angina, myocardial necrosis and other diseases, and can also treat symptoms such as angina, fever and the like; the fructus cannabis contains various substances such as ursolic acid, jute diglucoside, jute glucoside and the like, can effectively play a role in strengthening, can inhibit and treat symptoms such as heart failure, arrhythmia and the like, has high effect taking speed and good treatment effect, and can treat symptoms such as cold, cough and the like. The raw material medicines are matched with each other, have synergistic interaction, can effectively inhibit various pathogenic microorganisms such as bacteria, fungi, viruses and the like, have the effects of resisting infection and diminishing inflammation, can effectively relieve and treat symptoms such as fever, cough, vomiting, palpitation, heart rate disorder, heart failure and the like caused by viral myocarditis, and have good treatment effect.
Further, in some embodiments of the present invention, the raw materials are used in the following amounts by weight: 14 parts of fructus forsythiae, 8 parts of cassia twig, 6 parts of radix stephaniae tetrandrae, 12 parts of radix ophiopogonis, 8 parts of calyx kaki, 10 parts of radix rubiae and 6 parts of fructus cannabis.
In the above embodiment, the dosage ratio of each raw material drug is further controlled, so that the raw material drugs can be better combined and matched with each other, and the synergistic effect is realized, so that each drug can fully exert respective beneficial effects, the treatment effect of the product drug can be further improved, and the use is more facilitated.
Further, in some embodiments of the present invention, the composition further comprises the following raw materials in parts by weight: 5-10 parts of spina date seeds.
In the embodiment, the spina date seed can play a role in calming the heart and soothing the nerves, nourishing the liver and arresting sweating, can treat symptoms such as dysphoria and insomnia, palpitation and severe palpitation, body deficiency and spontaneous sweating, night sweat and the like, contains various substances such as spina date seed alkali, betulinic acid, spinaxanthin and the like, can play a role in calming the nerves and soothing the nerves, can improve the sleep quality, has a positive effect on a cardiovascular system, can resist arrhythmia, can treat symptoms of myocardial ischemia, has a heart strengthening effect, and can improve the immunity of an organism. By adding the spina date seeds, the treatment effect of the product medicine on the viral myocarditis can be better improved, and the treatment is more facilitated.
Furthermore, in some embodiments of the present invention, the dosage form of the traditional Chinese medicine composition for treating viral myocarditis is granules.
In the embodiment, the product is prepared into a granular dosage form, so that the product is more favorable for transportation, carrying and storage, is more convenient to use, can better exert the drug effect of the product, is convenient for human body to absorb, and is more favorable for treatment.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for treating viral myocarditis, which comprises the following steps: pulverizing fructus forsythiae, ramulus Cinnamomi, radix Stephaniae Tetrandrae, radix Ophiopogonis, calyx kaki, radix Rubiae and radix Seu folium Cayratiae Japonicae, adding ethanol, reflux extracting for two times, filtering, and recovering ethanol to obtain extractive solution and residue; adding water into the residues, decocting, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract, drying, and pulverizing to obtain the final product.
In the embodiment, fructus forsythiae, cassia twig, radix stephaniae tetrandrae, radix ophiopogonis, calyx kaki, radix rubiae and radix cannabis are firstly crushed, so that beneficial ingredients in the raw medicinal materials can be more fully extracted in the subsequent steps, and the curative effect of the product medicament is improved; then adding ethanol into the crushed medicinal materials, carrying out reflux extraction, adding water into obtained decoction dregs for decoction, combining the two extraction means of reflux extraction and decoction, and extracting beneficial components in the medicinal materials more fully, so that the medicinal materials can be better combined and matched with each other, the synergistic effect is realized, the waste loss is avoided, and the medicinal effect and the quality of the product are further improved; mixing the leaching solution and the decoction, concentrating to obtain extract, and concentrating to further increase the concentration of the medicine and enhance the curative effect; and finally, drying and crushing to prepare a finished product, so that different formulations such as granules, tablets and the like can be conveniently prepared and the finished product is convenient to use. The whole preparation method has simple flow, and the prepared product has good curative effect and convenient and quick use.
Further, in some embodiments of the invention, ethanol at a concentration of 80% by volume is added for reflux extraction twice.
In the above embodiment, the volume concentration of the ethanol is limited, so that beneficial ingredients in the raw medicinal materials can be fully extracted through reflux extraction, the drug effect of the product is further improved, and the treatment effect of the product is enhanced.
Further, in some embodiments of the present invention, the weight ratio of ethanol to the raw material at each reflux extraction is 8:1, 2 hours each time.
In the above embodiment, through controlling the dosage of the ethanol that adds when leaching to the backward flow and the time of leaching to the backward flow, can be more abundant extract the beneficial component in the raw materials medicinal material, be favorable to further promoting product quality, more be favorable to the treatment to use.
Further, in some embodiments of the invention, the weight ratio of the added water to the raw material herbs in the decoction is 3:1, and the decoction is carried out for 45 min.
In the embodiment, by controlling the amount of water added during decoction and the decoction time, some residual beneficial components in the dregs after reflux extraction can be better extracted by decoction, the drug effect of the product is further improved, and the treatment effect is enhanced.
Further, in some embodiments of the present invention, the extract has a relative density of 1.1-1.3.
In the embodiment, the concentration of the medicine can be further improved and the treatment effect can be improved by concentrating the extract into the extract with the relative density of 1.1-1.3, and meanwhile, the prepared extract can be further processed into other different dosage forms more conveniently, so that the use is convenient and the treatment is more facilitated.
Further, in some embodiments of the invention, drying is performed at 40-45 ℃.
In the above embodiment, through controlling drying temperature, can be better carry out the drying to the extract, get rid of unnecessary moisture, also can avoid simultaneously causing adverse effect because of drying temperature is improper to the pharmaceutical composition in the product, be favorable to further promoting the quality of product medicine.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 5g, ramulus Cinnamomi 3g, radix Stephaniae Tetrandrae 5g, radix Ophiopogonis 8g, calyx kaki 5g, radix Rubiae 8g and radix Boehmeriae 5g, adding 80% ethanol, reflux-extracting twice, adding 312g ethanol each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 117g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the extractive solution and decoction, concentrating to obtain extract with relative density of 1.1, drying at 40 deg.C, pulverizing, and making into granule.
Example 2
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 15g, ramulus Cinnamomi 8g, radix Stephaniae Tetrandrae 8g, radix Ophiopogonis 15g, calyx kaki 10g, radix Rubiae 10g and radix Boehmeriae 10g, adding 80% ethanol, reflux-extracting twice, adding ethanol 608g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 228g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the extractive solution and decoction, concentrating to obtain extract with relative density of 1.3, drying at 45 deg.C, pulverizing, and making into granule.
Example 3
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 10g, ramulus Cinnamomi 6g, radix Stephaniae Tetrandrae 7g, radix Ophiopogonis 10g, calyx kaki 7g, radix Rubiae 9g and radix Seu caulis Kadsurae Longipedunculatae 8g, adding 80% ethanol, reflux-extracting twice, adding ethanol 456g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 171g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the extractive solution and decoction, concentrating to obtain extract with relative density of 1.2, drying at 45 deg.C, pulverizing, and making into granule.
Example 4
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 12g, ramulus Cinnamomi 4g, radix Stephaniae Tetrandrae 6g, radix Ophiopogonis 12g, calyx kaki 6g, radix Rubiae 8g and radix Boehmeriae 6g, adding 80% ethanol, reflux-extracting twice, adding ethanol 432g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 162g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract with relative density of 1.2, drying at 44 deg.C, pulverizing, and making into granule.
Example 5
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 14g, ramulus Cinnamomi 8g, radix Stephaniae Tetrandrae 6g, radix Ophiopogonis 12g, calyx kaki 8g, radix Rubiae 10g, and radix Boehmeriae 6g, adding 80% ethanol, reflux-extracting twice, adding ethanol 512g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 192g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract with relative density of 1.2, drying at 44 deg.C, pulverizing, and making into granule.
Example 6
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 14g, ramulus Cinnamomi 8g, radix Stephaniae Tetrandrae 6g, radix Ophiopogonis 12g, calyx kaki 8g, radix Rubiae 10g, radix Boehmeriae 6g and semen Ziziphi Spinosae 5g, adding 80% ethanol, reflux extracting twice, adding ethanol 552g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 207g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract with relative density of 1.2, drying at 44 deg.C, pulverizing, and making into granule.
Example 7
The embodiment provides a traditional Chinese medicine composition for treating viral myocarditis, which is prepared by the following method: respectively pulverizing fructus forsythiae 14g, ramulus Cinnamomi 8g, radix Stephaniae Tetrandrae 6g, radix Ophiopogonis 12g, calyx kaki 8g, radix Rubiae 10g, radix Boehmeriae 6g and semen Ziziphi Spinosae 8g, adding 80% ethanol, reflux extracting twice, adding ethanol 576g each time, and each time for 2 hr; filtering and recovering ethanol to obtain leaching solution and residue; adding 216g of water into the residues, decocting for 45min, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract with relative density of 1.2, drying at 44 deg.C, pulverizing, and making into granule.
Test examples
The traditional Chinese medicine composition for treating viral myocarditis provided by example 7 of the present invention was administered to 37 patients with viral myocarditis, among which 15 male patients aged 20-42 years; 22 female patients, age 18-46 years; the treatment is continued for 14-30 days, the average change of the myocardial zymogram before and after the treatment of the patient is detected and counted, and the detection result is shown in the table 1:
TABLE 1
According to the detection result, the traditional Chinese medicine composition for treating viral myocarditis can effectively improve the myocardial zymogram index of a patient, and has an obvious treatment effect.
The following are some typical cases:
patient 1, male, 38 years old, diagnosed with viral myocarditis; fever, nausea, vomiting and other symptoms exist in the early stage, and the general aching, limp and aching pain is often felt, and then palpitation and chest distress symptoms appear; by using the traditional Chinese medicine composition for treating viral myocarditis provided by the invention, symptoms are basically controlled after the traditional Chinese medicine composition is continuously treated for 14 days, and the symptoms are cured after 20 days, and all indexes are recovered to be normal.
Patient 2, female, age 21, diagnosed with viral myocarditis; fever symptoms exist in the early stage, and then chest distress, cough and asthma are often caused, the symptoms are aggravated after exercise, and occasional palpitations are caused; the traditional Chinese medicine composition for treating viral myocarditis provided by the invention has the advantages that symptoms basically disappear after the traditional Chinese medicine composition is continuously treated for 14 days, all indexes are restored to be normal through detection, and the treatment effect is obvious.
Patient 3, male, age 42, diagnosed with viral myocarditis; chest distress, weakness and dizziness are often felt, arrhythmia of a patient is detected, and cardiac function is reduced; by using the traditional Chinese medicine composition for treating viral myocarditis provided by the invention, symptoms are basically controlled after the traditional Chinese medicine composition is continuously used for treating viral myocarditis for 14 days, and the symptoms are recovered after 30 days, all indexes are recovered to be normal, and the treatment effect is obvious.
In summary, according to the traditional Chinese medicine composition for treating viral myocarditis and the preparation method thereof provided by the embodiment of the invention, fructus forsythiae contains multiple substances such as phillyrin, forsythin aglycone and oleanolic acid, which have inhibitory effects on staphylococcus aureus, pneumococcus, streptococcus A, streptococcus B, catarrhal coccus, shigella flexneri, paratyphoid A, escherichia coli, pneumobacillus and other bacteria and fungi, and also have inhibitory and resistant effects on viruses, so that fever, pharyngalgia and other symptoms similar to cold in the early stage of viral myocarditis can be treated, and the detoxification effect is achieved; the cassia twig contains various components such as cinnamaldehyde, benzyl benzoate, calamus alkene and the like, has the effect of inhibiting and resisting various bacteria such as staphylococcus albus, shigella, typhoid and paratyphoid bacillus, pneumococcus, aerobacter, proteus, bacillus anthracis, salmonella enteritidis, vibrio cholerae and the like and various viruses such as influenza virus and the like, also has the effect of diuresis, and can relieve and treat symptoms such as chest stuffiness, palpitation and the like; the stephania tetrandra contains multiple substances such as tetrandrine, flavonoid glycoside and the like, can effectively play roles in diminishing inflammation, easing pain, clearing heat and resisting allergy, can also inhibit the generation of anaphylactic shock symptoms, and simultaneously has the effects of resisting bacteria, protozoans and tumors; the ophiopogon contains various glucoside substances, can effectively prevent and resist arrhythmia symptoms, can improve the immunity of the organism, has the effects of strengthening heart, calming, resisting fatigue and the like, can relieve and treat arrhythmia and other symptoms caused by viral myocarditis, and can repair damaged cardiac muscle cells; the calyx kaki contains oleanolic acid, betulinic acid, quercetin, etc., and can be used for treating emesis, regurgitation, arrhythmia, and viral myocarditis; the sea madder contains alginic acid, mannitol and other substances, has the effects of resisting tumor, blood coagulation and infection, has positive effects on cardiovascular systems, can relieve and treat angina, myocardial necrosis and other diseases, and can also treat symptoms such as angina, fever and the like; the fructus cannabis contains various substances such as ursolic acid, jute diglucoside, jute glucoside and the like, can effectively play a role in strengthening, can inhibit and treat symptoms such as heart failure, arrhythmia and the like, has high effect taking speed and good treatment effect, and can treat symptoms such as cold, cough and the like. The raw material medicines are matched with each other, have synergistic interaction, can effectively inhibit various pathogenic microorganisms such as bacteria, fungi, viruses and the like, have the effects of resisting infection and diminishing inflammation, can effectively relieve and treat symptoms such as fever, cough, vomiting, palpitation, heart rate disorder, heart failure and the like caused by viral myocarditis, and have good treatment effect.
The preparation method comprises the steps of firstly, crushing fructus forsythiae, cassia twig, radix stephaniae tetrandrae, radix ophiopogonis, calyx kaki, radix rubiae and radix cannabis, and is beneficial to more fully extracting beneficial components in the raw medicinal materials in the subsequent steps, so that the curative effect of the product medicament is improved; then adding ethanol into the crushed medicinal materials, carrying out reflux extraction, adding water into obtained decoction dregs for decoction, combining the two extraction means of reflux extraction and decoction, and extracting beneficial components in the medicinal materials more fully, so that the medicinal materials can be better combined and matched with each other, the synergistic effect is realized, the waste loss is avoided, and the medicinal effect and the quality of the product are further improved; mixing the leaching solution and the decoction, concentrating to obtain extract, and concentrating to further increase the concentration of the medicine and enhance the curative effect; and finally, drying and crushing to prepare a finished product, so that different formulations such as granules, tablets and the like can be conveniently prepared and the finished product is convenient to use. The whole preparation method has simple flow, and the prepared product has good curative effect and convenient and quick use.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for treating viral myocarditis is characterized by comprising the following raw materials in parts by weight: 5-15 parts of fructus forsythiae, 3-8 parts of cassia twig, 5-8 parts of radix stephaniae tetrandrae, 8-15 parts of radix ophiopogonis, 5-10 parts of calyx kaki, 8-10 parts of radix rubiae and 5-10 parts of radix linderae.
2. The traditional Chinese medicine composition for treating viral myocarditis according to claim 1, wherein the dosage of each raw material is as follows in parts by weight: 14 parts of fructus forsythiae, 8 parts of cassia twig, 6 parts of radix stephaniae tetrandrae, 12 parts of radix ophiopogonis, 8 parts of calyx kaki, 10 parts of radix rubiae and 6 parts of fructus cannabis.
3. The traditional Chinese medicine composition for treating viral myocarditis according to claim 1, further comprising the following raw materials in parts by weight: 5-10 parts of spina date seeds.
4. The traditional Chinese medicine composition for treating viral myocarditis according to claim 1, wherein the traditional Chinese medicine composition for treating viral myocarditis is in the form of granules.
5. A method for preparing the traditional Chinese medicine composition for treating viral myocarditis according to claim 1, comprising the following steps: pulverizing fructus forsythiae, ramulus Cinnamomi, radix Stephaniae Tetrandrae, radix Ophiopogonis, calyx kaki, radix Rubiae and radix Seu folium Cayratiae Japonicae, adding ethanol, reflux extracting for two times, filtering, and recovering ethanol to obtain extractive solution and residue; adding water into the residues, decocting, and filtering to obtain decoction; mixing the leaching solution and the decoction, concentrating to obtain extract, drying, and pulverizing to obtain the final product.
6. The method of claim 5, wherein the ethanol with a concentration of 80% by volume is added for reflux extraction twice.
7. The preparation method of the traditional Chinese medicine composition for treating viral myocarditis according to claim 5, wherein the weight ratio of the ethanol added to the raw medicinal materials in each reflux extraction is 8:1, and each reflux extraction is 2 hours.
8. The preparation method of the traditional Chinese medicine composition for treating viral myocarditis according to claim 5, wherein the weight ratio of water to raw medicinal materials in decoction is 3:1, and the decoction is carried out for 45 min.
9. The method for preparing a Chinese medicinal composition for treating viral myocarditis according to claim 5, wherein the relative density of the extract is 1.1-1.3.
10. The method of claim 5, wherein the drying is carried out at a temperature of 40-45 ℃.
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| Title |
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| 刘德培: "《中华医学百科全书》", 31 July 2019 * |
| 赵景梅: "中药治疗病毒性心肌炎35例", 《陕西中医》 * |
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