CN112689638A - 作为lsd1抑制剂的环丙胺类化合物及其应用 - Google Patents

作为lsd1抑制剂的环丙胺类化合物及其应用 Download PDF

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Publication number
CN112689638A
CN112689638A CN201980060312.2A CN201980060312A CN112689638A CN 112689638 A CN112689638 A CN 112689638A CN 201980060312 A CN201980060312 A CN 201980060312A CN 112689638 A CN112689638 A CN 112689638A
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compound
isomer
pharmaceutically acceptable
added
acceptable salt
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CN112689638B (zh
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吴凌云
汪秋燕
黎健
陈曙辉
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Nanchang Hongyi Technology Co Ltd
Nanchang Hongyi Pharmaceutical Co Ltd
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Medshine Discovery Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

一类作为赖氨酸特异性去甲基化酶1(LSD1)抑制剂的环丙胺类化合物，及其在制备治疗与LSD1相关疾病的药物中的应用。所述环丙胺类化合物是式(Ⅰ)所示化合物、其异构体及其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201980060312.2A 2018-09-13 2019-09-12 作为lsd1抑制剂的环丙胺类化合物及其应用 Active CN112689638B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018110703196 2018-09-13
CN201811070319 2018-09-13
CN2019101006296 2019-01-31
CN201910100629 2019-01-31
PCT/CN2019/105683 WO2020052649A1 (zh) 2018-09-13 2019-09-12 作为lsd1抑制剂的环丙胺类化合物及其应用

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CN112689638A true CN112689638A (zh) 2021-04-20
CN112689638B CN112689638B (zh) 2022-11-08

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EP (1) EP3851440A4 (zh)
JP (1) JP7233523B2 (zh)
CN (1) CN112689638B (zh)
WO (1) WO2020052649A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085176A (zh) * 2021-12-01 2022-02-25 吉尔生化（上海）有限公司 一种5-Boc-5-氮杂螺[2.3]己烷-1-羧酸的合成方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022171044A1 (zh) * 2021-02-09 2022-08-18 南昌弘益药业有限公司 一种氧氮杂螺环化合物、其盐型及其晶型
JP2024513260A (ja) 2021-04-08 2024-03-22 オリゾン ジェノミックス ソシエダッド アノニマ 骨髄癌処置のためのｌｓｄ１阻害剤の組み合わせ
WO2022267495A1 (zh) * 2021-06-22 2022-12-29 南昌弘益药业有限公司 含氮氧杂螺环类化合物及其应用
WO2023217784A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
WO2023217758A1 (en) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103857393A (zh) * 2011-03-25 2014-06-11 葛兰素史密斯克莱知识产权（第2号）有限公司 环丙基胺作为lsd1抑制剂
CN104203914A (zh) * 2011-10-20 2014-12-10 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
WO2017195216A1 (en) * 2016-05-09 2017-11-16 Jubilant Biosys Limited Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101794020B1 (ko) 2010-04-19 2017-11-06 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
CR20180152A (es) * 2015-08-12 2018-08-09 Incyte Corp Sales de un inhibidor de lsd1
WO2018081343A1 (en) 2016-10-26 2018-05-03 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and medical uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103857393A (zh) * 2011-03-25 2014-06-11 葛兰素史密斯克莱知识产权（第2号）有限公司 环丙基胺作为lsd1抑制剂
CN104203914A (zh) * 2011-10-20 2014-12-10 奥瑞泽恩基因组学股份有限公司 作为lsd1抑制剂的(杂)芳基环丙胺化合物
WO2017195216A1 (en) * 2016-05-09 2017-11-16 Jubilant Biosys Limited Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114085176A (zh) * 2021-12-01 2022-02-25 吉尔生化（上海）有限公司 一种5-Boc-5-氮杂螺[2.3]己烷-1-羧酸的合成方法

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JP2022500449A (ja) 2022-01-04
JP7233523B2 (ja) 2023-03-06
CN112689638B (zh) 2022-11-08
US11649245B2 (en) 2023-05-16
WO2020052649A1 (zh) 2020-03-19
EP3851440A1 (en) 2021-07-21
EP3851440A4 (en) 2022-06-08
US20220119401A1 (en) 2022-04-21

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