CN112656856B - Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof - Google Patents
Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof Download PDFInfo
- Publication number
- CN112656856B CN112656856B CN202110072172.XA CN202110072172A CN112656856B CN 112656856 B CN112656856 B CN 112656856B CN 202110072172 A CN202110072172 A CN 202110072172A CN 112656856 B CN112656856 B CN 112656856B
- Authority
- CN
- China
- Prior art keywords
- essential oil
- parts
- chinese medicine
- traditional chinese
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for treating constipation, and in particular relates to traditional Chinese medicine compound essential oil for treating chronic transmission type constipation. The raw materials of the traditional Chinese medicine compound essential oil comprise the following components: the essential oil is prepared by respectively extracting immature bitter orange, bighead atractylodes rhizome and magnolia officinalis through steam distillation. The invention is externally used, can effectively promote gastrointestinal peristalsis, improves slow transmission constipation rat SP substance and 5-HT abnormity, and has obvious treatment effect on slow transmission constipation.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition for treating constipation, and in particular relates to traditional Chinese medicine compound essential oil for treating chronic transmission type constipation.
Background
Chronic transit constipation (STC) is a common functional constipation in clinic, which means that the colonic transit time is prolonged, the colonic movement propulsion and contraction movement are reduced after eating due to colonic motility disorder, and the clinical manifestations of stool frequency reduction, stool disappearance, dry and hard stool quality, abdominal distension and the like are caused. The disease seriously affects the life quality and physical and psychological health of patients, and long-term constipation can induce cardiovascular and cerebrovascular diseases and anal diseases, and is closely related to colorectal cancer, Alzheimer disease and other diseases. Most studies are thought to be associated with gastrointestinal hormone level disorders, gastrointestinal motility deficiencies, changes in the number and morphology of Cajal interstitial cells (ICC), intestinal nervous system transmitter content, and intestinal flora imbalance.
In modern medicine, the existing treatment methods for chronic transmission constipation mainly comprise laxatives and prokinetic agents, biofeedback, operations, excrement transplantation and the like, but serious adverse reactions are caused, drug dependence is easy to form, the operations and the excrement transplantation are difficult to generally develop clinically, and the recurrence rate of operation treatment is high. The traditional Chinese medicine has the advantages of obvious curative effect and good safety in treating the disease.
The traditional Chinese medicine essential oil is prepared by using modern scientific and technological means in limited and precise aspects of planting and collecting raw materials, extracting and refining products and absorbing the essential oil, so that the effect of the traditional Chinese medicine essential oil is greatly improved, and the aim of 'pure natural herbal essence' is not violated. The aromatic medicine has the functions of regulating qi, activating spleen and promoting appetite, and the essential oil of the traditional Chinese medicine is applied to the umbilical part, so that the smell of the medicine enters the blood along with the qi, is transmitted to the internal organs through meridians and collaterals, and is distributed on the whole body through the circulation of blood vessels, thereby correcting the pathological states of the five internal organs and the six internal organs.
Chinese patent application CN110812405A discloses a poncirus trifoliata flower essential oil for treating functional constipation, which is prepared by dissolving and uniformly mixing 57mL of rheum officinale essential oil, 4-6mL of fructus forsythiae essential oil, 5-7mL of pharbitis seed essential oil, 5-7mL of fructus aurantii immaturus essential oil, 5-7mL of radix linderae essential oil, 4-6mL of rose essential oil and 5-7g of menthol, and can effectively improve the constipation function, but the compound medicine has a lot of flavors and adopts supercritical CO2The extraction method has special requirements on equipment and is relatively complex in process.
Chinese patent application CN109846937A discloses a gastrointestinal conditioning essential oil and a preparation method thereof, which consists of 3 to 6 weight percent of essential oil components, and the balance of base oil; the essential oil comprises the following components in parts by weight: 1-3 parts of oxide essential oil, 25-40 parts of sesquiterpene essential oil, 1-3 parts of aromatic aldehyde essential oil, 3-7 parts of phenol essential oil and 3-7 parts of ketone essential oil. Has the effects of regulating intestines and stomach, invigorating stomach, promoting digestion, increasing intestinal absorption capacity and gastrointestinal peristalsis, and effectively regulating flatulence, defecation, persistent stools, constipation, loose stools and other phenomena. The invention is prepared by directly blending essential oil, and the essential oil has various types and high cost.
The Chinese patent CN102600353B discloses an external traditional Chinese medicine bag for treating chronic constipation of old people and a preparation method thereof, and the external traditional Chinese medicine bag for treating chronic constipation of old people provided by the invention comprises the following components: the medicine in the medicine bag acts on the Shenque point of the umbilical region, and medicine gas continuously permeates into the body to play a role of relaxing the bowels, thereby achieving the curative effect of treating the chronic constipation of the old. However, the medicine bag has more medicinal ingredients, adopts the medicinal powder directly, has limited medicinal effect and is inconvenient and uncomfortable to use.
Therefore, the developed traditional Chinese medicine compound essential oil has the advantages of simple prescription, good safety, convenient use and obvious curative effect on chronic transmission constipation, and has important social value.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides compound essential oil for regulating chronic transmission type constipation, and a preparation method and application thereof. The aromatic medicine has the functions of regulating qi, activating spleen and promoting appetite, thereby improving the chronic transmission type constipation symptom. Experiments prove that the compound essential oil has obvious curative effect on chronic transmission constipation, good safety, simple preparation method, convenience and practicability.
The invention aims to provide a traditional Chinese medicine compound essential oil for treating chronic transmission type constipation, which comprises the following raw materials: immature bitter orange essential oil, bighead atractylodes rhizome essential oil and magnolia officinalis essential oil.
The invention also carries out volatile oil extraction on other traditional Chinese medicine ingredients, wherein rheum officinale, dried orange peel, elecampane, perilla frutescens, sandalwood, nardostachys chinensis, immature bitter orange, bighead atractylodes rhizome, mangnolia officinalis, fennel, fingered citron, amomum tsao-ko, katsumadai seed, nutmeg, fructus evodiae, rhizoma atractylodis, fructus amomi, pogostemon cablin, eupatorium fortunei, rhizoma acori graminei, agilawood, cinnamon, folium artemisiae argyi, clove, green tangerine orange flower, radix bupleuri, rhizoma cyperi and angelica sinensis also have the effects of treating constipation to different degrees.
Preferably, the raw materials of the traditional Chinese medicine compound essential oil also comprise base oil, wherein the base oil is any one of sweet almond oil, wheat germ oil, walnut kernel oil, grape seed oil, jojoba oil, evening primrose oil, rose hip oil, walnut oil, olive oil, avocado oil and almond oil;
preferably, the base oil is jojoba oil.
Preferably, the raw materials of the traditional Chinese medicine compound essential oil comprise the following components in parts by weight: 4-10 parts of immature bitter orange essential oil, 2-8 parts of bighead atractylodes rhizome essential oil, 2-8 parts of officinal magnolia bark essential oil and 20-90 parts of jojoba oil;
preferably, the raw materials of the traditional Chinese medicine compound essential oil comprise the following components in parts by weight: 4-8 parts of immature bitter orange essential oil, 2-5 parts of bighead atractylodes rhizome essential oil, 2-5 parts of officinal magnolia bark essential oil and 45-90 parts of jojoba oil.
Preferably, the traditional Chinese medicine compound essential oil for treating chronic transmission constipation provided by the invention comprises the following components: 4 parts of immature bitter orange essential oil, 2 parts of bighead atractylodes rhizome essential oil, 3 parts of officinal magnolia bark essential oil and 90 parts of jojoba oil.
Preferably, the part ratio of the white atractylodes rhizome essential oil to the magnolia bark essential oil is 1: 1-2.5.
Still another object of the present invention is to provide a composition comprising the essential oil of the herbal compound according to any one of claims 1 to 4.
Preferably, the composition is selected from any one of transdermal preparation, sachet, medicated pillow, medicated incense and sachet.
The invention also aims to provide a preparation method of the traditional Chinese medicine compound essential oil, which comprises the following steps:
(1) pulverizing fructus Aurantii Immaturus, Atractylodis rhizoma and cortex Magnolia officinalis, respectively extracting by steam distillation, and drying to obtain essential oil;
(2) and (2) uniformly mixing the immature bitter orange essential oil, the bighead atractylodes rhizome essential oil, the magnolia officinalis essential oil and the jojoba oil in the step (1) to obtain the compound essential oil.
Preferably, the volume-to-mass ratio of the water added in the step (1) to the extracted medicinal material is 8-12 mL/g; preferably 10 mL/g.
Preferably, the pressure of the steam distillation method in the step (1) is 300-.
Preferably, the time for extracting by the steam distillation method in the step (1) is 7-10 h.
Preferably, anhydrous Na is used in the step (1)2SO4And (5) drying.
The invention further aims to provide application of the traditional Chinese medicine compound essential oil in preparation of a medicine for treating chronic transmission type constipation.
The invention has the beneficial effects that:
(1) the traditional Chinese medicine compound essential oil disclosed by the invention is simple in prescription, obvious in curative effect on chronic transmission type constipation, good in safety, convenient to use and important in social value;
(2) according to the invention, by limiting the proportion of the essential oils and further determining the proportion of the bighead atractylodes rhizome and the magnolia bark essential oil, the finally prepared traditional Chinese medicine compound essential oil can achieve the effect of treating chronic transmission constipation at the same level as that of a chemical medicine, and has no toxic or side effect;
(3) the compound essential oil developed by the invention is used externally, is convenient to use and has good patient compliance.
Detailed Description
Example 1
The traditional Chinese medicine compound essential oil for treating chronic transmission constipation is prepared from the following components: 10 parts of immature bitter orange essential oil, 8 parts of bighead atractylodes rhizome essential oil, 8 parts of officinal magnolia bark essential oil and 90 parts of jojoba oil.
The preparation method of the traditional Chinese medicine compound essential oil comprises the following steps:
(1) pulverizing fructus Aurantii Immaturus, sieving with 24 mesh sieve, adding 10 times of water, extracting by steam distillation at 100 deg.C under 400mbar for 10 hr, and passing through anhydrous Na2SO4Drying to obtain fructus Aurantii Immaturus essential oil;
(2) pulverizing Atractylodis rhizoma, sieving with 24 mesh sieve, adding 12 times of water, extracting by steam distillation at 300mbar and 95 deg.C for 8 hr, and extracting with anhydrous Na2SO4Drying to obtain Atractylodis rhizoma essential oil;
(3) pulverizing cortex Magnolia officinalis, sieving with 24 mesh sieve, adding 8 times of water, extracting by steam distillation at 100 deg.C under 500mbar for 5 hr, and passing through anhydrous Na2SO4Drying to obtain Atractylodis rhizoma essential oil;
(4) the immature bitter orange essential oil, the bighead atractylodes rhizome essential oil, the officinal magnolia bark essential oil and the jojoba oil are mixed to obtain the traditional Chinese medicine compound essential oil.
Example 2
The traditional Chinese medicine compound essential oil for treating chronic transmission constipation comprises the following components: 4 parts of immature bitter orange essential oil, 2 parts of bighead atractylodes rhizome essential oil, 3 parts of officinal magnolia bark essential oil and 20 parts of sweet almond oil.
The preparation method of the traditional Chinese medicine compound essential oil comprises the following steps:
(1) pulverizing fructus Aurantii Immaturus, sieving with 24 mesh sieve, adding 8 times of water, extracting by steam distillation at 100 deg.C under 300mbar for 5 hr, and purifying with anhydrous Na2SO4Drying to obtain fructus Aurantii Immaturus essential oil;
(2) pulverizing Atractylodis rhizoma, sieving with 24 mesh sieve, adding 10 times of water, extracting by steam distillation at 98 deg.C under 400mbar for 8 hr, and passing through anhydrous Na2SO4Drying to obtain Atractylodis rhizoma essential oil;
(3) pulverizing cortex Magnolia officinalis, sieving with 24 mesh sieve, adding 12 times of water, extracting under 500mbar and 100 deg.C by steam distillation for 10 hr, and passing through anhydrous Na2SO4Drying to obtain cortex Magnolia officinalis essential oil;
(4) the immature bitter orange essential oil, the bighead atractylodes rhizome essential oil, the officinal magnolia bark essential oil and the jojoba oil are mixed to obtain the traditional Chinese medicine compound essential oil.
Example 3
The traditional Chinese medicine compound essential oil for treating chronic transmission constipation comprises the following components: 6 parts of immature bitter orange essential oil, 3 parts of bighead atractylodes rhizome essential oil, 7.5 parts of officinal magnolia bark essential oil and 50 parts of walnut kernel oil.
The preparation method of the traditional Chinese medicine compound essential oil comprises the following steps:
(1) pulverizing fructus Aurantii Immaturus, sieving with 24 mesh sieve, adding 10 times of water, extracting by steam distillation at 400mbar and 95 deg.C for 10 hr, and extracting with anhydrous Na2SO4Drying to obtain fructus Aurantii Immaturus essential oil;
(2) pulverizing Atractylodis rhizoma, sieving with 24 mesh sieve, adding 12 times of water, extracting by steam distillation at 100 deg.C under 300mbar for 8 hr, and passing through anhydrous Na2SO4Drying to obtain Atractylodis rhizoma essential oil;
(3) pulverizing cortex Magnolia officinalis, sieving with 24 mesh sieve, adding 8 times of water, extracting by steam distillation at 100 deg.C under 500mbar for 5 hr, and passing through anhydrous Na2SO4Drying to obtain Atractylodis rhizoma essential oil;
(4) the immature bitter orange essential oil, the bighead atractylodes rhizome essential oil, the officinal magnolia bark essential oil and the jojoba oil are mixed to obtain the traditional Chinese medicine compound essential oil.
Comparative example 1
The difference from example 1 is that 8 parts of magnolia bark essential oil is removed, 16 parts of white atractylodes rhizome essential oil is adjusted, and the rest is the same as example 1.
Comparative example 2
The difference from example 1 is that 8 parts of white atractylodes rhizome essential oil is removed, and the magnolia bark essential oil is adjusted to 16 parts, and the rest is the same as example 1.
Comparative example 3
The difference from the example 1 is that the white atractylodes rhizome essential oil is adjusted to 12 parts, the magnolia bark essential oil is adjusted to 4 parts, and the mass ratio of the white atractylodes rhizome essential oil to the magnolia bark essential oil is 3: 1.
comparative example 4
The difference with example 1 is that the parts of the essential oil are not in the range of the mixture ratio claimed in the present application. Specifically, the traditional Chinese medicine composition comprises 3 parts of immature bitter orange essential oil, 12 parts of bighead atractylodes rhizome essential oil, 10 parts of officinal magnolia bark essential oil and 60 parts of jojoba oil.
Comparative example 5
The traditional Chinese medicine compound essential oil for treating chronic transmission constipation in the comparative example comprises the following components: 10 parts of immature bitter orange essential oil, 8 parts of rhubarb essential oil, 8 parts of fructus forsythiae essential oil and 90 parts of sweet almond oil.
The preparation method of the traditional Chinese medicine compound essential oil comprises the following steps:
(1) pulverizing fructus forsythiae, sieving with 24 mesh sieve, adding 10 times of water, extracting under 400mbar and 100 deg.C by steam distillation for 10 hr, and passing through anhydrous Na2SO4Drying to obtain perilla essential oil;
(2) pulverizing radix et rhizoma Rhei, sieving with 24 mesh sieve, adding 12 times of water, extracting by steam distillation at 90 deg.C under 300mbar for 8 hr, and extracting with anhydrous Na2SO4Drying to obtain fingered citron essential oil;
(3) pulverizing fructus Aurantii Immaturus, sieving with 24 mesh sieve, adding 8 times of water, extracting by steam distillation at 100 deg.C under 500mbar for 5 hr, and extracting with anhydrous Na2SO4Drying to obtain semen Myristicae essential oil;
(5) the immature bitter orange essential oil, the rhubarb essential oil, the forsythia essential oil and the sweet almond oil are mixed to obtain the traditional Chinese medicine compound essential oil.
Comparative example 6
Weighing the medicinal materials with the parts corresponding to 10 parts of immature bitter orange essential oil, 8 parts of bighead atractylodes rhizome essential oil and 8 parts of officinal magnolia bark essential oil in example 1, adding 10 times of water, soaking for 20min, heating and decocting for 1h, filtering to obtain filtrate 1, adding water to the medicinal residues, decocting for 30min, filtering to obtain filtrate 2, mixing the two filtrates, and concentrating until the relative density of the concentrated solution is 1.05(60 ℃), thus obtaining a decoction group.
Comparative example 7
The compound essential oil (10 parts of immature bitter orange essential oil, 8 parts of bighead atractylodes rhizome essential oil, 8 parts of officinal magnolia bark essential oil and 90 parts of jojoba oil) in the embodiment 1 is used as oral medicine.
Experimental example pharmacodynamic experiment of coating compound essential oil for treating chronic transmission constipation, in particular to the treatment effect of the compound essential oil on rats with chronic transmission constipation
Grouping: a total of thirteen groups; blank group, model group, positive group, compound essential oil group of examples 1-3, comparative examples 1-7;
molding and dosing:
a rat chronic transmission type constipation model is established by adopting the compound diphenoxylate tablets. The method specifically comprises the following steps: 104 SD rats with half male and female bodies, weight of 200 +/-20 g and 8 rats in each group; no drug was administered to the blank group; the other twelve groups are filled with compound diphenoxylate suspension according to the mass of 10 mg/(kg. d) for molding. The drug is administered separately starting from the 1 st week of molding while maintaining molding conditions, and molding is continued during the administration period.
Administration:
positive group: the administration dose of the mosapride is 1.58mg kg-1·d-1；
Blank and model groups: free diet;
examples 1-3 Compound essential oil compositions: the compound essential oil prepared by the implementation of the method is coated on the Shenque acupoint of a rat, and the coating dosages of all groups are respectively as follows: 0.588mL.kg-1.d-1。
Comparative examples 1-5 groups: the compound essential oil prepared in comparative examples 1 to 4 of the invention is respectively smeared on the Shenque acupoint of a rat, and the smearing dosage of each group is respectively0.588mL.kg-1.d-1。
Comparative example 6 (decoction group): the decoction is prepared into 6.3g.kg-1.d-1The dose of (2) is administered by intragastric administration once a day.
Comparative example 7 (oral essential oil group): the compound essential oil (10 parts of immature bitter orange essential oil, 8 parts of bighead atractylodes rhizome essential oil, 8 parts of officinal magnolia bark essential oil and 90 parts of jojoba oil) in the example 1 is administrated by intragastric administration to rats, after administration, a small amount of water is used for washing an administration container, and the washing liquid is intragastric administered again and is intragastric administered once a day.
The administration time is 21 days, and the patients are fasted after the last administration without water supply for 12 hours. After the last administration, the rats were filled with 10% activated carbon, and after 40min, the rats in each group were anesthetized with 20% urethane, then dissected, and the abdominal aorta was bled and the intestinal transit of the rats was examined.
Statistical method
Statistical analysis was performed using SPSS20.0 software, using a t-test between groups, and when P <0.05 or P <0.01, it was considered
The differences are statistically significant, and the data are expressed as mean. + -. standard deviation
And (4) showing.
Test results 1.: the specific results of each drug on intestinal propulsion in rats are shown in table 1.
TABLE 1 comparison of intestinal carbon advancement rates of rats in groups: (
n＝8)
Note: the difference between the letters indicates that the two groups of comparisons have significant statistical differences, P < 0.05.
It can be seen that the intestinal propulsion of the rats in the model group was decreased (p <0.01) compared to the blank group, the intestinal propulsion of the rats in the compound essential oil group was increased (p <0.05) compared to the model group, and the intestinal propulsion rate of the compound essential oil group was statistically different from that of the comparative group.
Test results 2 measurement of SP content in serum
After the abdominal aorta was bled, it was centrifuged at 3000rpm at 4 ℃ for 10min, and the supernatant serum was taken and the content of SP in the rat serum was measured by Substance P (SP) ELISA kit. The results of the measurement of the SP content in the serum by each drug group are shown in table 2 below.
TABLE 2 serum SP content of rats of each group: (
n＝8)
| Group of | n | SP(ng/mL) |
| Blank group | 8 | 6.34±0.38a |
| Model set | 8 | 3.23±0.46b |
| Positive group | 8 | 4.13±0.51d |
| Example 1 | 8 | 5.39±0.74c |
| Example 2 | 8 | 5.47±0.60c |
| Example 3 | 8 | 5.83±0.68c |
| Comparative example 1 | 8 | 3.66±0.46d |
| Comparative example 2 | 8 | 3.80±0.39d |
| Comparative example 3 | 8 | 4.33±0.51d |
| Comparative example 4 | 8 | 3.94±0.36d |
| Comparative example 5 | 8 | 4.15±0.90d |
| Comparative example 6 | 8 | 4.06±0.17d |
| Comparative example 7 | 8 | 4.59±0.62d |
Note: the difference between the letters indicates that the two groups of comparisons have significant statistical differences, P < 0.05.
The results show that: compared with the blank group, the serum SP content of the rats in the model group is obviously reduced, and the rats in the model group have obvious difference (p <0.01) among the groups. After administration, compared with a model group, the SP of the compound essential oil rat serum of the groups of examples 1-3 is remarkably increased, the significance among the groups is poor (p is less than 0.01), and meanwhile, compared with a comparative example group and a positive group, the compound essential oil rat serum of each example group has the significance on the effect of increasing the SP content of the rat serum.
Test results 3 Effect of each drug group on 5-HT content in colonic tissue
Immediately taking 1cm of colon tissue 11cm away from the anus after blood is taken from the abdominal aorta, washing the colon tissue by PBS, sucking water by using filter paper, freezing the colon tissue at the temperature of minus 80 ℃ for later use, measuring the 5-HT content in the colon tissue according to the operation steps of the 5-HT detection kit, and detecting the total protein content in a sample by using the BCA kit.
TABLE 3 5-HT content in colon tissue of rats in each group: (
n＝8)
| Group of | n | Colon 5-HT (pg/mg) |
| Blank group | 8 | 246.96±26.22a |
| Model set | 8 | 91.13±24.68b |
| Positive group | 8 | 188.69±51.71c |
| Example 1 | 8 | 183.99±29.14c |
| Example 2 | 8 | 195.41±37.04c |
| Example 3 | 8 | 186.25±33.84c |
| Comparative example 1 | 8 | 130.14±22.87d |
| Comparative example 2 | 8 | 136.29±27.31d |
| Comparative example 3 | 8 | 167.93±26.06d |
| Comparative example 4 | 8 | 143.69±29.81d |
| Comparative example 5 | 8 | 148.93±25.68d |
| Comparative example 6 | 8 | 150.61±20.37d |
| Comparative example 7 | 8 | 156.42±19.26d |
Note: the difference between the letters indicates that the two groups of comparisons have significant statistical differences, P < 0.05.
The results show that: compared with the blank group, the rat colon content of the model group is extremely reduced remarkably, and the rats have remarkable difference among the groups. After administration, the colon 5-HT content of the compound essential oil and the rat in the positive group in the groups of examples 1-3 is remarkably increased compared with that of the model group, and the groups have remarkable difference, wherein the colon 5-HT content of the rat in the compound essential oil group has remarkable statistical difference compared with that of the control group.
In conclusion, the traditional Chinese medicine essential oil is compounded and externally used for treating chronic transmission type constipation, convenience is brought, the compliance of patients is good, and the effect is obvious through animal experiments, so that the embodiment group is superior to the decoction group, and the decoction group is superior to the oral essential oil group.
According to the invention, under a specific proportion, the immature bitter orange essential oil, the white atractylodes rhizome essential oil and the magnolia bark essential oil are used for obviously improving the effect of chronic transmission constipation, the carbon powder propulsion rate of a model rat can be obviously improved, the SP content in the serum of the rat is obviously improved, the 5-HT content in the colon of the rat is obviously improved, the effect is equivalent to that of a positive group, and the method has a better trend, provides great convenience for elderly patients who are not suitable for oral administration, and has good market prospect and profound social significance.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (13)
1. The traditional Chinese medicine compound essential oil for treating constipation is characterized by comprising the following raw materials in parts by weight: 4-10 parts of immature bitter orange essential oil, 2-8 parts of bighead atractylodes rhizome essential oil, 2-8 parts of officinal magnolia bark essential oil and 20-90 parts of jojoba oil; the administration route of the traditional Chinese medicine compound essential oil is transdermal administration.
2. The compound essential oil of traditional Chinese medicine according to claim 1, wherein the raw materials of the compound essential oil of traditional Chinese medicine comprise the following components in parts by weight: 4-8 parts of immature bitter orange essential oil, 2-5 parts of bighead atractylodes rhizome essential oil, 2-5 parts of officinal magnolia bark essential oil and 45-90 parts of jojoba oil.
3. The traditional Chinese medicine compound essential oil according to claim 2, wherein the part ratio of the bighead atractylodes rhizome essential oil to the magnolia bark essential oil is 1: 1-2.5.
4. A composition comprising the essential oil of the herbal compound of any one of claims 1-3.
5. The composition of claim 4, wherein the composition is selected from transdermal formulations.
6. The preparation method of the traditional Chinese medicine compound essential oil according to any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) pulverizing fructus Aurantii Immaturus, Atractylodis rhizoma and cortex Magnolia officinalis, extracting by steam distillation, and drying to obtain essential oil;
(2) and (2) uniformly mixing the immature bitter orange essential oil, the bighead atractylodes rhizome essential oil, the magnolia officinalis essential oil and the jojoba oil in the step (1) to obtain the compound essential oil.
7. The preparation method according to claim 6, wherein the volume-to-mass ratio of the water added in step (1) to the extracted crude drug is 8-12 mL/g.
8. The preparation method according to claim 7, wherein the volume-to-mass ratio of the water to the extracted medicinal material is 10 mL/g.
9. The method as claimed in claim 6, wherein the pressure of the steam distillation method in the step (1) is 300-500mbar and the temperature is 95-100 ℃.
10. The method according to claim 6, wherein the extraction time by steam distillation in the step (1) is 7 to 10 hours.
11. The method according to claim 6, wherein the drying in the step (1) is performed with anhydrous Na2SO4And (5) drying.
12. Use of the essential oil of a herbal compound according to any one of claims 1 to 3, the composition according to claim 4 or 5, or the essential oil of a herbal compound prepared by the preparation method according to any one of claims 6 to 11 in the preparation of a product for treating constipation.
13. The use of claim 12, wherein the constipation is slow transit constipation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110072172.XA CN112656856B (en) | 2021-01-19 | 2021-01-19 | Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110072172.XA CN112656856B (en) | 2021-01-19 | 2021-01-19 | Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112656856A CN112656856A (en) | 2021-04-16 |
| CN112656856B true CN112656856B (en) | 2022-05-27 |
Family
ID=75415778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110072172.XA Active CN112656856B (en) | 2021-01-19 | 2021-01-19 | Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112656856B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172685A (en) * | 2013-01-30 | 2013-06-26 | 向华 | Method for extracting hesperidin and synephrine from immature bitter oranges |
| CN107375597A (en) * | 2016-05-16 | 2017-11-24 | 重庆百笑医疗设备有限公司 | A kind of moxibustion motive small intestine system channels and network vessels regulation essential oils |
-
2021
- 2021-01-19 CN CN202110072172.XA patent/CN112656856B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103172685A (en) * | 2013-01-30 | 2013-06-26 | 向华 | Method for extracting hesperidin and synephrine from immature bitter oranges |
| CN107375597A (en) * | 2016-05-16 | 2017-11-24 | 重庆百笑医疗设备有限公司 | A kind of moxibustion motive small intestine system channels and network vessels regulation essential oils |
Non-Patent Citations (1)
| Title |
|---|
| 基于网络药理学的枳实挥发油治疗慢性传输型便秘的机制研究;王梁凤 等;《中国中药杂志》;20200430;第45卷(第8期);第1909-1917页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112656856A (en) | 2021-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101822704B (en) | Drug combination for removing freckles and preparation method thereof | |
| CN104491801A (en) | Traditional Chinese medicine preparation for treating acute or chronic gastritis and preparation method thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN105288537A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparing method thereof | |
| CN100421699C (en) | Compound Chinese medicinal preparation for treating male sterility | |
| CN104491802A (en) | Application of traditional Chinese medicine preparation in preparation of medicine for treating acute or chronic gastritis | |
| CN112656856B (en) | Traditional Chinese medicine compound essential oil for treating constipation and preparation method thereof | |
| CN105796845A (en) | Application of medicine composition in preparing medicine for treating female climacteric syndromes | |
| CN105031123A (en) | Fat reducing traditional Chinese medicine preparation and preparation method thereof | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN105412424A (en) | Pharmaceutical preparation containing argy wormwood leaves and having bowel relaxing function as well as preparation method of pharmaceutical preparation | |
| CN105770673A (en) | Application of Chinese herba preparation containing folium artemisiae argyi in preparing drug for treating chronic gastritis | |
| CN107669910B (en) | Pharmaceutical composition for treating atherosclerosis | |
| CN107260851B (en) | Traditional Chinese medicine composition for treating deficiency constipation | |
| CN105362629A (en) | Female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae and preparation method of female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae | |
| CN105288128A (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparing method thereof | |
| CN116236551B (en) | Traditional Chinese medicine composition for treating spleen deficiency and excessive dampness syndrome type spleen stomach diseases and preparation method thereof | |
| CN114533835B (en) | A Chinese medicinal composition with effects of removing pathogenic wind and dampness, and its preparation method | |
| CN102247551A (en) | Medicament for treating constipation | |
| CN107469014A (en) | A kind of pharmaceutical composition for treating female mammary gland proliferation disease and preparation method thereof | |
| CN111407868B (en) | Traditional Chinese medicine pill for improving cognitive function of brain | |
| CN106266962A (en) | A kind of medicament composing prescription for the nursing of puerpera's postpartum depression and preparation method | |
| CN116492438A (en) | Xia Changqing tonic preparation for tonifying blood and its preparation method | |
| CN104491316A (en) | Traditional Chinese medicine preparation for treating middle-warmer energy insufficiency type prostate hyperplasia | |
| CN116036165A (en) | Traditional Chinese medicine composition for treating novel coronavirus and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |