CN112654430B - Inflated membrane structure virus detection laboratory, biosafety laboratory and earthing structure virus detection laboratory - Google Patents

Abstract

An inflatable membrane structure virus detection laboratory, a biosafety laboratory and a soil-covered structure virus detection laboratory. The laboratory comprises: the inflatable membrane structure can form a clean area, a buffer unit and a high pollution area after being inflated; the access device integration module includes an access door; the outlet equipment integration module comprises a garbage transfer box; the device also comprises a bidirectional heat exchange fresh air fan, so that the high pollution area is in a negative pressure environment. The modularized design of the laboratory can be realized by arranging the inlet and outlet equipment integrated modules, centralized management of equipment is facilitated, and the inflatable membrane structure can form a house body or a tubular body through inflation, so that the rapid construction of the inflatable membrane structure virus detection laboratory is facilitated, and the inflatable membrane structure virus detection laboratory is put into use as soon as possible; in addition, the high pollution area is in a negative pressure environment, so that the use safety in virus detection is guaranteed.

Description

Inflated membrane structure virus detection laboratory, biosafety laboratory and earthing structure virus detection laboratory

Technical Field

The application relates to the field of protection isolation buildings, in particular to an inflatable membrane structure virus detection laboratory, a biosafety laboratory with the inflatable membrane structure virus detection laboratory, a earthing structure virus detection laboratory with the inflatable membrane structure virus detection laboratory, and an earthing structure virus detection laboratory with the biosafety laboratory.

Background

In 2020, after the outbreak of a large-scale epidemic situation in China, the serious deficiency of a virus detection laboratory (or biosafety laboratory) for virus detection and research is caused except for the huge demands on epidemic prevention hospitals, shelter hospitals and isolation places.

Biosafety laboratories are laboratories built by canonical laboratory designs, configuration of laboratory equipment, use of individual protective equipment, and the like. Whenever epidemic situation or related event of sudden infectious disease occurs, the related samples (including human body, animals, environment and the like) collected on site are rapidly sent to a biosafety protection laboratory for detection and discrimination (detection) of potential biosensing factors (pathogens, toxins and the like) so as to effectively support on-site scientific decision making and rapid response.

The traditional virus detection laboratory mostly adopts traditional prefabricated building structure, needs indoor negative pressure system to handle polluted air, has brought the implementation cost higher, and construction cycle is longer, and difficult demolishs after the build, also can't pack in advance and reserve, problem such as site selection difficulty. When the virus epidemic situation bursts on a large scale, the traditional existing virus detection laboratory or biosafety laboratory obviously cannot meet the flexible and timely construction requirements.

Therefore, there is a need for a virus detection site that is fast, easy and meets a high biosafety level.

Disclosure of Invention

The present application aims to solve, at least to some extent, one of the above technical problems in the prior art. Therefore, the application provides an inflatable membrane structure virus detection laboratory, and the integration degree is higher and can realize constructing fast.

The application also provides a biosafety laboratory with the inflatable membrane structure virus detection laboratory.

The application also provides a soil-covered structure virus detection laboratory with the aerated film structure virus detection laboratory.

The application further provides a soil-covered structure virus detection laboratory with the biosafety laboratory.

An inflatable membrane structured virus detection laboratory according to an embodiment of the first aspect of the present application comprises: inflation can form an inflatable membrane structure of a house body or a tubular body; the inflatable membrane structure can form a functional space after being inflated, a clean area, one or more buffer units used as auxiliary functional areas and a high pollution area used as a main functional area are arranged in the functional space, the buffer units are defined by the inflatable membrane structure, the buffer units separate the clean area from the high pollution area, and the buffer units are provided with inner opening and closing doors which are in airtight separation or communication with the clean area and the high pollution area; the entrance equipment integrated module is arranged at one end of the functional space and at least comprises an entrance door, and the entrance door is hermetically isolated or communicated with the clean area; the outlet equipment integrated module is arranged at the other end of the functional space and at least comprises a garbage transfer box; at least one of the inlet equipment integrated module and the outlet equipment integrated module further comprises a bidirectional heat exchange fresh air fan with a filtering device, wherein the bidirectional heat exchange fresh air fan is used for conveying gas to the functional space or extracting gas from the functional space; by means of the bidirectional heat exchange fresh air fan, the high pollution area can be in a negative pressure environment.

According to the inflatable membrane structure virus detection laboratory, through the arrangement of the inlet equipment integrated module and the outlet equipment integrated module, the modularized design of the laboratory can be realized, centralized management of equipment is facilitated, and the inflatable membrane structure can form a house body or a tubular body through inflation, so that the rapid construction of the inflatable membrane structure virus detection laboratory is facilitated, and the inflatable membrane structure virus detection laboratory is put into use as soon as possible; in addition, the high pollution area is in a negative pressure environment, so that the use safety in virus detection is guaranteed.

According to some embodiments of the present application, the buffer unit and the clean zone are both in a negative pressure environment, and the pressure relationships of the clean zone, the buffer unit, and the high pollution zone are: the clean area > the buffer unit > the high contamination area.

According to some embodiments of the present application, the inflated membrane structured virus detection laboratory further comprises: and at least one air column air pipe with one end extending into the functional space, and the other end of the air column air pipe is connected with the corresponding bidirectional heat exchange fresh air fan.

Further, a first air pipe opening communicated with the clean area, a second air pipe opening communicated with the buffer unit and a third air pipe opening communicated with the high pollution area are formed in the air column air pipe.

According to some embodiments of the present application, the bidirectional heat exchange fresh air fan includes: an inlet side bidirectional heat exchange fresh air machine belonging to the inlet equipment integrated module and an outlet side bidirectional heat exchange fresh air machine belonging to the outlet equipment integrated module.

Further, at least one of the inlet equipment integrated module and the outlet equipment integrated module further comprises an air conditioner outdoor unit, and an air conditioner indoor unit is arranged in the functional space.

Specifically, the air conditioner outdoor unit includes: an inlet side air conditioning outdoor unit belonging to the inlet equipment integrated module and an outlet side air conditioning outdoor unit belonging to the outlet equipment integrated module.

Further, the inlet device integration module further includes: the inlet equipment frame, the inlet side air conditioning outdoor unit and the inlet side bidirectional heat exchange fresh air fan are arranged on the inlet equipment frame.

According to some embodiments of the application, the inlet device integration module further comprises: and the disinfection sewage tank is placed on the inlet equipment rack.

According to some embodiments of the present application, the access door is an intelligent interactive access door, and the access door is opened and closed in a contactless manner.

According to some embodiments of the application, the outlet device integration module further comprises: the garbage transfer box, the air conditioner outdoor unit at the outlet side and the bidirectional heat exchange fresh air fan at the outlet side are arranged on the outlet equipment frame.

According to some embodiments of the application, the outlet device integration module further comprises: the fire escape emergency door is in airtight partition or communication with the high pollution area.

According to some embodiments of the present application, at least one of the clean zone, the buffer unit, the high pollution zone is provided with a smoke alarm system.

According to some embodiments of the application, at least one of the clean zone, the buffer unit, and the high pollution zone is provided with a dry powder fire extinguisher.

According to some embodiments of the present application, one or more air disinfection devices are disposed within the high pollution area, the air disinfection devices comprising: any one or more of a plasma sterilizer, an ultraviolet ozone generator and a dry fog type hydrogen peroxide sterilizer.

According to some embodiments of the present application, the buffer unit includes: the first dressing room and the second dressing room are mutually independent, and the first dressing room and the second dressing room are respectively provided with the inner opening and closing door.

Further, an inlet channel is formed among the inlet door, the inner opening and closing door between the first dressing room and the clean area, the inner opening and closing door between the first dressing room and the high pollution area, and an outlet channel is formed among the inner opening and closing door between the second dressing room and the high pollution area, the inner opening and closing door between the second dressing room and the clean area and the inlet door.

According to some embodiments of the present application, the opening and closing manner of the inner opening and closing door includes: any one or a combination of a plurality of zippers, magnetic attraction, adhesion, hooks and buckles.

According to some embodiments of the present application, an illumination lamp band is disposed in the functional space, and the illumination lamp band is fixed on the inflatable membrane structure through a velcro and/or a binding band.

According to some embodiments of the present application, the inflatable membrane structure comprises an inflatable membrane dome structure and an inflatable membrane isolation structure, the functional space is defined by the inflatable membrane dome structure after inflation, and the cushioning unit is defined by the inflatable membrane isolation structure.

According to some embodiments of the present application, the inflatable membrane dome structure comprises: the inflatable ring is an inflatable ring with a positive pressure air film space inside.

Further, the inner side of the air-filled ring is covered with a single-layer film.

According to some embodiments of the present application, the inflatable membrane dome structure comprises: the support frame that is located the outside and the single-layer membrane or the bilayer membrane that are located the inboard, the single-layer membrane be suitable for with form the air film space that is full of the malleation between the support frame, bilayer membrane is the bilayer membrane that has the malleation air film space inside.

According to some embodiments of the present application, the inflatable membrane dome structure comprises: the support air column frame is formed by constructing a plurality of support air columns with positive pressure air film spaces inside, and the outer side of the support air column frame is covered with a single-layer film or a double-layer film with the positive pressure air film spaces.

According to some embodiments of the present application, the inflatable membrane structure has a membrane structure filling port and a membrane structure air outlet, wherein the membrane structure filling port is communicated with the membrane structure filling port, the air blower is communicated with the membrane structure filling port and blows air into the membrane structure filling port, and the air inlet amount at the membrane structure filling port is larger than the air outlet amount at the membrane structure air outlet, so that the membrane structure is a positive pressure membrane structure.

According to some embodiments of the present application, the high pollution area is provided with a humidifier to meet the humidity requirement; and/or one or more skylights are arranged at the top of the high pollution area and used for lighting or ventilation, and an inward unidirectional filter device is arranged at the skylights.

According to some embodiments of the present application, the high contamination zone has a first transfer port and a second transfer port, the first transfer port and the second transfer port being adapted to be provided with a transfer unit.

Optionally, the transfer unit is a material transfer box and/or a personnel access box.

According to some embodiments of the application, the transfer unit and the garbage transfer box each comprise an inner door facing the high pollution area and an outer door facing the outside, and the transfer unit and the garbage transfer box each adopt an intelligent interaction technology, so that the inner door and the outer door form an intelligent interlocking structure, and the inner door and the outer door cannot be opened simultaneously.

According to some embodiments of the present application, the inflatable membrane structure enables folding storage by pumping out gas.

According to some embodiments of the present application, the inflatable membrane structure exterior surface can be upgraded or retrofitted to permanent buildings by any one or a combination of spraying building industry materials, casting concrete, and covering vegetation.

A biosafety laboratory according to an embodiment of a second aspect of the application comprising: a plurality of inflatable membrane structured virus detection laboratories according to embodiments of the first aspect of the present application, wherein the second transfer port of one of the inflatable membrane structured virus detection laboratories is aligned with the first transfer port of an adjacent one of the inflatable membrane structured virus detection laboratories and connected by the transfer unit.

According to some embodiments of the present application, the two inflatable membrane structure virus detection laboratories are provided, and the second transfer port of the first inflatable membrane structure virus detection laboratory is aligned with the first transfer port of the second inflatable membrane structure virus detection laboratory and connected by the transfer unit.

According to some embodiments of the present application, the highly contaminated region of the first aerated film structure virus detection laboratory is a sample receiving and preparation region, and the highly contaminated region of the second aerated film structure virus detection laboratory is an amplification region.

According to some embodiments of the present application, the first transfer port of the first inflatable membrane structured virus detection laboratory is a first sample inlet, and the second transfer port of the second inflatable membrane structured virus detection laboratory is a second sample inlet.

Specifically, a sample inactivation area, a sample unpacking and information verification area, a sample tube transfer plate area and a sample preparation area are arranged in the high pollution area of the first inflatable membrane structure virus detection laboratory so as to meet the receiving and preparation flow of samples.

Further, a drying box is arranged at the sample inactivation area, and samples are inactivated in the drying box; the sample unpacking and information verifying area is provided with a first biosafety cabinet, and unpacking and information verifying are carried out on the sample in the first biosafety cabinet; a second biosafety cabinet is arranged at the sample tube rotating plate area, and the sample tube is rotated in the second biosafety cabinet; a sample nucleic acid extractor is disposed at the sample preparation zone for automated extraction of sample nucleic acids.

Optionally, any one or more combinations of a centrifuge, a refrigerator, a printer and an oscillator are further arranged in the high pollution area of the first inflatable membrane structure virus detection laboratory.

Optionally, the drying oven is disposed adjacent to the first sample inlet.

According to some embodiments of the application, a nucleic acid amplification instrument is disposed in the highly contaminated region of the second inflatable membrane structured virus detection laboratory to satisfy the amplification procedure of the sample.

Optionally, any one or more combinations of a centrifuge, a refrigerator and an oscillator are further arranged in the high pollution area of the second inflatable membrane structure virus detection laboratory.

According to some embodiments of the present application, the drying oven, the first biosafety cabinet, the second biosafety cabinet, the sample nucleic acid extractor, the nucleic acid amplification instrument are used sequentially.

Optionally, an autoclave for sterilizing medical waste is further arranged in the high-pollution area of the first inflatable membrane structure virus detection laboratory and the second inflatable membrane structure virus detection laboratory.

According to some embodiments of the present application, a side of the first inflatable membrane structured virus detection laboratory facing away from the second inflatable membrane structured virus detection laboratory is provided with at least one first auxiliary inflatable membrane structured virus detection laboratory for assisting in sample receiving and preparation procedures;

One side of the second inflatable membrane structure virus detection laboratory, which is far away from the first inflatable membrane structure virus detection laboratory, is provided with at least one second auxiliary inflatable membrane structure virus detection laboratory for auxiliary amplification flow;

the first auxiliary inflatable membrane structure virus detection laboratory and the second auxiliary inflatable membrane structure virus detection laboratory are both the inflatable membrane structure virus detection laboratory.

According to the biosafety laboratory of the embodiment of the second aspect of the application, physical separation of the respective functional regions by the transfer unit is advantageous in improving the safety of use of the biosafety laboratory, for example, once the nucleic acid diffused in the amplification region leaks, the leaked nucleic acid can be prevented from entering the sample receiving and preparing region.

An earthing structure virus-testing laboratory according to an embodiment of the third aspect of the present application, comprising: the air-filled membrane structure virus detection laboratory according to the embodiment of the first aspect of the present application, wherein the outer surface of the air-filled membrane structure is formed by any one or more of spraying building industrial materials, pouring concrete, and covering vegetation, so that the air-filled membrane structure virus detection laboratory becomes a long-lasting soil-covered structure building.

An earthing structure virus test laboratory according to an embodiment of the fourth aspect of the present application, comprising: the biosafety laboratory of an embodiment of the second aspect of the application, the outer surface of the inflatable membrane structure is formed into a long-lasting soil-covered structure building by any one or more of spraying building industry materials, pouring concrete, and covering vegetation.

Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.

Drawings

FIG. 1 is a schematic diagram of a biosafety laboratory;

FIG. 2 is a schematic illustration of a biosafety laboratory with the inflatable membrane structure removed;

FIG. 3 is an internal schematic diagram of a biosafety laboratory;

FIG. 4 is a schematic cross-sectional view of a first embodiment of an inflatable membrane dome structure;

FIG. 5 is a schematic cross-sectional view of a second embodiment of an inflatable membrane dome structure;

FIG. 6 is a schematic cross-sectional view of a third embodiment of an inflatable membrane dome structure;

FIG. 7 is a top view of a third embodiment of an inflatable membrane dome structure;

FIG. 8 is a schematic illustration of a people stream flow line of a biosafety laboratory;

FIG. 9 is a schematic illustration of a facility flow line of a biosafety laboratory;

FIG. 10 is a schematic view of a material flow line of a biosafety laboratory;

FIG. 11 is a schematic diagram of another embodiment of a biosafety laboratory.

Reference numerals:

the biological sample preparation device comprises an inflatable membrane structure 1, an inner membrane 11, an outer membrane 12, a single-layer membrane 13, an inflatable ring 14, a supporting frame 15, a supporting air column frame 16, a supporting air column 161, an air membrane space 17, a membrane structure air outlet 18, a functional space 19, a clean room 2, a buffer unit 3, a first dressing room 31, a second dressing room 32, an inner opening and closing door 33, a high pollution area 4, a first transfer port 41, a second transfer port 42, a middle material transfer box 43, a feeding transfer box 44, a personnel channel box 45, an inlet device integration module 5, an inlet door 51, an inlet side bidirectional heat exchange fresh air machine 52, an inlet side air conditioning outdoor machine 53, an inlet device frame 54, a disinfection and sterilization sewage box 55, an air blast frame 56, an outlet device integration module 6, a garbage transfer box 61, an outlet side bidirectional heat exchange fresh air machine 62, an outlet side air conditioning outdoor machine 63, an outlet device frame 64, a fire emergency door 65, an air column air pipe 71, an air conditioning indoor machine 72, an air device 73, an illuminating lamp belt 74, a centrifuge 81, a refrigerator 82, a printer 83, an oscillator 84, a pressure cooker 85, a first sterilizing membrane structure 10, a drying cabinet 101, a second biological sample preparation device 101, a biological sample preparation device detection laboratory safety device 101, an air-saving laboratory safety device 101, an inlet device 101, an air-saving laboratory safety detector, an air-sample detection device 101, an air-saving device 101, a nucleic acid sample detection device, an amplification device, an air-saving laboratory device, and an air-permeable instrument.

Detailed Description

Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and intended for the purpose of explaining the present application and are not to be construed as limiting the present application.

In this application, unless specifically stated and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; may be mechanically connected, may be electrically connected or may communicate with each other; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art as the case may be.

The inflatable membrane structure building system is an innovative building technology developed in the years, has the advantages of high building speed, high cost performance, convenience in daily storage, high volume compression ratio, rapidness in transportation, convenience in resource allocation among various cities and convenience in timely mass production and building by utilizing the existing production system.

The following describes in detail the inflated membrane structured virus detection laboratory according to an embodiment of the present application with reference to fig. 1 to 11.

Referring to fig. 1-3, an inflatable membrane structured virus detection laboratory according to an embodiment of a first aspect of the present application may include: the inflatable membrane structure 1, which is inflatable to form a house or a tubular body, an inlet device integration module 5 and an outlet device integration module 6.

Referring to fig. 2-3, the inflatable membrane structure 1, when inflated, forms a functional space 19, and an experimenter can perform virus detection and other auxiliary tasks (e.g., changing protective clothing, etc.) in the functional space 19. The inflatable membrane structure 1 can be formed after being inflated, which is beneficial to the rapid construction of the functional space 19. For areas with large detection volume, the detection pressure can be greatly relieved in a short time by using a virus detection laboratory with a gas-filled membrane structure which can be quickly built. Furthermore, the inflatable membrane structure 1 can be removed after deflation, so that after completion of the detection task, the inflatable membrane structure virus detection laboratory can be removed to free up space there.

Referring to fig. 2 to 3, there are a clean zone 2, a highly contaminated zone 4, one or more buffer units 3 in the functional space 19, the buffer units 3 being used as auxiliary functional areas, for example, replacement of protective clothing can be performed in the buffer units 3; the highly contaminated region 4 is used as a main functional region, for example, reception, preparation, amplification, etc. of a sample can be performed within the highly contaminated region 4.

Referring to fig. 3, a buffer unit 3 may be defined by the air-filled membrane structure 1, the buffer unit 3 separating the clean zone 2 from the high-pollution zone 4, and the buffer unit 3 having an inner opening and closing door 33 hermetically closing or communicating with the clean zone 2 and the high-pollution zone 4. Thereby realizing the physical isolation of the three areas of the clean zone 2, the buffer unit 3 and the high pollution zone 4.

As shown in fig. 1 to 3, the entrance equipment integration module 5 is disposed at one end of the functional space 19, and the entrance equipment integration module 5 includes at least an entrance door 51, and the entrance door 51 is hermetically isolated or communicated with the clean zone 2.

In a specific embodiment, the entrance door 51 may be a single-layer door, and the clean zone 2 may communicate with the outside when the entrance door 51 is opened; the denuded zone 2 may be isolated from the outside when the access door 51 is closed.

In other alternative embodiments, the access door 51 may be a double door, and the double door includes an inner door and an outer door, at which time the access door 51 may be configured as a smart interactive access door, such as a light interactive access door, that enables the inner door and the outer door to be intelligently interlocked, i.e., the inner door and the outer door are configured to not be opened simultaneously, to provide isolation of the clean zone 2 from the outside. For example, when the inner door of the entrance door 51 is opened and the outer door is closed, the inner space of the entrance door 51 communicates with the clean zone 2 to be isolated from the outside; when the outer door of the entrance door 51 is opened and the inner door is closed, the inner space of the entrance door 51 communicates with the outside to be isolated from the clean zone 2.

As shown in fig. 1-3, the outlet device integration module 6 is provided at the other end of the functional space 19, and the outlet device integration module 6 includes at least a waste transfer bin 61. The garbage generated in the functional space 19 can be transferred to the outside from the garbage transfer box 61 after being sterilized.

At least one of the inlet device integration module 5 and the outlet device integration module 6 further comprises a bi-directional heat exchange fresh air fan with filtering means for delivering air to the functional space 19 or withdrawing air from the functional space 19, that is, the bi-directional heat exchange fresh air fan can realize the air extraction and air supply functions. The number of the two-way heat exchange fresh air fans can be set to be multiple, and the working modes can also have various combinations, for example, when one part of the two-way heat exchange fresh air fans draw out air from the functional space 19, the other part of the two-way heat exchange fresh air fans send air to the functional space 19; or all the two-way heat exchange fresh air machines simultaneously convey the gas to the functional space 19 for a period of time and then switch the two-way heat exchange fresh air machines to simultaneously extract the gas from the functional space 19, and the actions of conveying the gas and extracting the gas can be alternately performed.

Through the action of air extraction and air supply of the bidirectional heat exchange fresh air machine, the directional flow of air can be formed in the functional space 19, and the bidirectional heat exchange fresh air machine is provided with the filtering device, so that the air inlet and outlet are subjected to efficient filtration, the substances such as dust and particles in the external air are prevented from being brought into the functional space 19, viruses in the functional space 19 are prevented from being brought to the outside, and the use safety of the inflated membrane structure virus detection laboratory is ensured to be higher.

By means of the bidirectional heat exchange fresh air fan, the high pollution area 4 can be in a negative pressure environment. For example, when the amount of gas delivered by the bi-directional heat exchange ventilator to the high pollution area 4 is less than the amount of gas drawn from the high pollution area 4 by the bi-directional heat exchange ventilator, a negative pressure environment is present within the high pollution area 4. By setting the high pollution area 4 to a negative pressure environment, pathogenic microorganisms in the high pollution area 4 can be effectively prevented from diffusing into the external environment.

In some alternative embodiments, the amount of the gas sent by the bidirectional heat exchange fresh air fan to the high pollution area 4 is larger than the amount of the gas pumped by the bidirectional heat exchange fresh air fan from the high pollution area 4, and the positive pressure environment is arranged in the high pollution area 4.

Alternatively, the filter device may be a multi-layer HEPA (High efficiency particulate air Filter, high efficiency air filter) high efficiency filter, which is a filter that meets HEPA standards, with an effective rate of 99.7% for 0.1 and 0.3 microns, and the HEPA filter is characterized by air passing through but fine particles not passing through. It has particle eliminating efficiency over 99.97% and is effective in eliminating fume, dust, bacteria and other pollutant. HEPA is divided into five materials of PP filter paper, glass fiber, composite PP PET filter paper, melt-blown terylene non-woven fabric and melt-blown glass fiber. The characteristics are as follows: the air resistance is large, the dust holding capacity is large, the filtering precision is high, and the dust holding device can be processed into various sizes and shapes according to the needs of customers and is suitable for different machine types.

According to the inflatable membrane structure virus detection laboratory disclosed by the embodiment of the application, through the arrangement of the inlet equipment integrated module 5 and the outlet equipment integrated module 6, the modularized design of the inflatable membrane structure virus detection laboratory can be realized, the equipment on the inlet side is integrated in the inlet equipment integrated module 5, the equipment on the outlet side is integrated in the outlet equipment integrated module 6, centralized management of the equipment is facilitated, the appearance of the laboratory is concise and attractive, the inflatable membrane structure 1 can form a house body or a tubular body through inflation, the quick construction of the inflatable membrane structure virus detection laboratory is facilitated, the time from construction to loss before use of the inflatable membrane structure virus detection laboratory is greatly shortened, and the inflatable membrane structure virus detection laboratory can be put into use as soon as possible; in addition, the interior of the high pollution area 4 is in a negative pressure environment, which is beneficial to ensuring the use safety when detecting viruses, so that the laboratory meets the corresponding biosafety level specification.

In some embodiments, the high pollution zone 4, the buffer unit 3 and the clean zone 2 are all under negative pressure, that is, the functional space 19 is under negative pressure, so that when the entrance door 51 is opened and the clean zone 2 is communicated with the outside, air only flows from the outside to the clean zone 2, but air in the clean zone 2 does not flow to the outside, which is beneficial to improving the use safety performance of the inflated membrane structure virus detection laboratory.

The clean zone 2, the buffer unit 3 and the high pollution zone 4 form air pressure difference, and the pressure relations among the clean zone 2, the buffer unit 3 and the high pollution zone 4 are as follows: the clean area 2 is larger than the buffer unit 3 and larger than the high pollution area 4, namely the negative pressure of the clean area 2 is weakest, and the negative pressure of the high pollution area 4 is strongest. Thus, when the denuded zone 2 communicates with the buffer unit 3, air flows only from the denuded zone 2 having a weak negative pressure to the buffer unit 3, but cannot flow from the buffer unit 3 to the denuded zone 2, and the contamination of the denuded zone 2 due to the flow of the gas in the buffer unit 3 to the denuded zone 2 is avoided. When the buffer unit 3 is communicated with the high pollution area 4, air only flows from the buffer unit 3 with weak negative pressure to the high pollution area 4, but cannot flow from the high pollution area 4 to the buffer unit 3, so that the pollution of the buffer unit 3 caused by the flow of dirty gas in the high pollution area 4 to the buffer unit 3 is avoided. The negative pressure at the high pollution area 4 is strongest, so that pathogenic microorganisms in the high pollution area 4 can be effectively prevented from diffusing outwards, and the use safety performance of the inflatable membrane structure virus detection laboratory is further improved.

Referring to fig. 2, the inflated membrane structure virus detection laboratory may further include: at least one air column air pipe 71 with one end extending into the functional space 19, and the other end of the air column air pipe 71 is connected with a corresponding bidirectional heat exchange fresh air machine.

Further, the air column air duct 71 is provided with a first air duct opening communicated with the clean area 2, a second air duct opening communicated with the buffer unit 3 and a third air duct opening communicated with the high pollution area 4. When the bidirectional heat exchange fresh air machine works, air can be conveyed to the corresponding clean area 2, the buffer unit 3 and the high pollution area 4 through the first air pipe opening, the second air pipe opening and the third air pipe opening on the air column air pipe 71, or the air can be pumped out from the corresponding clean area 2, the buffer unit 3 and the high pollution area 4.

The air column air pipes 71 are in one-to-one correspondence with the two-way heat exchange fresh air fans.

In this application, the terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", or a third "may explicitly or implicitly include one or more such feature. In the description of the present application, the meaning of "plurality" is at least two, such as two, three, etc., unless explicitly defined otherwise.

In the embodiment of fig. 1-2, the bi-directional heat exchange fresh air machine may include: an inlet-side bidirectional heat exchange fresh air fan 52 belonging to the inlet device integration module 5 and an outlet-side bidirectional heat exchange fresh air fan 62 belonging to the outlet device integration module 6. As shown in fig. 2, the inlet-side bidirectional heat exchange fresh air fan 52 is connected to the inlet-side air column duct 71, and the outlet-side bidirectional heat exchange fresh air fan 62 is connected to the outlet-side air column duct 71.

In some embodiments, the inlet side bi-directional heat exchange fresh air mover 52 may be configured as a fresh air mover that delivers air to the functional space 19 and the outlet side bi-directional heat exchange fresh air mover 62 may be configured as a fresh air mover that draws air from the functional space 19. The inlet side bidirectional heat exchange fresh air fan 52 and the outlet side bidirectional heat exchange fresh air fan 62 can be arranged in a plurality to improve the efficiency of air suction and air supply.

Further, at least one of the inlet device integration module 5 and the outlet device integration module 6 further includes an air conditioning outdoor unit, and an air conditioning indoor unit 72 is disposed in the functional space 19. The air conditioning outdoor unit and the air conditioning indoor unit 72 constitute an air conditioning system to regulate the temperature in the functional space 19.

Specifically, as shown in fig. 1 to 2, the air conditioner outdoor unit includes: an inlet-side air-conditioning outdoor unit 53 belonging to the inlet equipment integration module 5 and an outlet-side air-conditioning outdoor unit 63 belonging to the outlet equipment integration module 6.

Further, the inlet device integration module 5 further includes: the inlet equipment rack 54, the inlet-side air conditioning outdoor unit 53, and the inlet-side bidirectional heat exchange fresh air fan 52 are placed on the inlet equipment rack 54.

As shown in fig. 2, the inlet device integration module 5 further includes: the disinfection sewage tank 55, and the disinfection sewage tank 55 is placed on the inlet equipment rack 54. The inlet equipment rack 54 may be configured as a multi-layered rack, so that the inlet side air-conditioning outdoor unit 53, the inlet side bidirectional heat exchange fresh air fan 52 and the disinfection sewage tank 55 may be arranged in a layered manner, for example, the inlet side bidirectional heat exchange fresh air fan 52 may be arranged at the uppermost layer, so that the inlet side bidirectional heat exchange fresh air fan 52 is conveniently connected with the air column air pipe 71; the disinfection tank 55 is heavy and may be disposed at the bottom layer to ensure good stability of placement. Meanwhile, the layered arrangement is beneficial to saving space and further realizing the integrated design of a laboratory.

Alternatively, the access door 51 is an intelligent interactive access door, and the access door 51 is opened and closed in a contactless manner. Thus, the experimenter can enter and exit the door 51 without touching the door 51. In some alternative embodiments, the access door 51 may be a light interactive access door, and the access door 51 may be instructed to open or close by means of a cell phone flash or flash ring, etc. In alternative embodiments, the access door 51 may be a voice interactive access door, with voice commands to effect the opening or closing of the access door 51. In this way, it is ensured that the entrance door 51 can be controlled without using a face scan even when the experimenter wears the protective suit.

As shown in fig. 2, the outlet device integration module 6 further includes: the outlet equipment rack 64, the trash transfer box 61, the outlet side air conditioning outdoor unit 63, and the outlet side bidirectional heat exchange fresh air fan 62 are placed on the outlet equipment rack 64. The outlet equipment rack 64 may be configured as a multi-layered support, so that the garbage transfer box 61, the outlet side air conditioning outdoor unit 63 and the outlet side bidirectional heat exchange fresh air fan 62 may be arranged in a layered manner, for example, the outlet side bidirectional heat exchange fresh air fan 62 may be arranged at the uppermost layer, so that the outlet side bidirectional heat exchange fresh air fan 62 is conveniently connected with the air column air pipe 71; the garbage transfer box 61 is frequently used, and can be arranged at the bottommost layer, and garbage passing through the garbage transfer box 61 can be prevented from falling on the outlet side air conditioner outdoor unit 63 and the outlet side bidirectional heat exchange fresh air fan 62. Meanwhile, the layered arrangement is beneficial to saving space and further realizing the integrated design of a laboratory.

Referring to fig. 2 to 3 and 8, the outlet device integration module 6 further includes: the fire escape emergency door 65, and the fire escape emergency door 65 is in airtight partition or communication with the high pollution area 4. When dangerous situations occur in the high pollution area 4, experimenters can escape quickly through the fire escape emergency door 65. The escape streamline is shown as a B streamline in FIG. 8.

In some embodiments, at least one area of the clean room 2, the buffer unit 3 and the high pollution area 4 is provided with a smoke alarm system, for example, the smoke alarm system can be arranged in the high pollution area 4, and the smoke alarm system can also be arranged in three areas of the clean room 2, the buffer unit 3 and the high pollution area 4. Through being equipped with smog alarm system, can play the warning effect when the laboratory takes place the condition of a fire to promote the fire control security performance of inflation film structure virus detection laboratory, guarantee its safety in utilization.

In some embodiments, at least one area of the clean room 2, the buffer unit 3 and the high pollution area 4 is provided with a dry powder fire extinguisher, for example, a dry powder fire extinguisher may be arranged in the high pollution area 4, and a dry powder fire extinguisher may also be arranged in three areas of the clean room 2, the buffer unit 3 and the high pollution area 4. By the dry powder fire extinguisher, small fire can be extinguished, and fire spread is prevented, so that the fire safety performance of the inflatable membrane structure virus detection laboratory is further improved, and the use safety of the inflatable membrane structure virus detection laboratory is ensured.

As shown in fig. 3, one or more air sterilizing apparatuses 73 are provided in the high pollution area 4, and the air sterilizing apparatuses 73 include: any one or more of a plasma sterilizer, an ultraviolet ozone generator and a dry fog type hydrogen peroxide sterilizer. By providing the air sterilizing device 73, the content of harmful air in the high pollution area 4 can be reduced, thereby ensuring the personal safety of the experimenters in the high pollution area 4. The air disinfection device 73 may be an ultraviolet vehicle, so that the air disinfection device 73 can move freely in the high pollution area 4 to disinfect the air in each area.

As shown in fig. 3, the buffer unit 3 includes: the first dressing room 31 and the second dressing room 32 are independent from each other, and the first dressing room 31 and the second dressing room 32 each have an inner opening and closing door 33.

Further, as shown in fig. 3 and 8, an inlet passage is formed between the inlet door 51, the inner opening and closing door 33 between the first dressing room 31 and the clean zone 2, the inner opening and closing door 33 between the first dressing room 31 and the high pollution zone 4, and an outlet passage is formed between the inner opening and closing door 33 between the second dressing room 32 and the high pollution zone 4, the inner opening and closing door 33 between the second dressing room 32 and the clean zone 2, and the inlet door 51. The personnel flow line of the experimental personnel in the inflated membrane structure virus detection laboratory can be shown as a flow line in fig. 8, namely: the experimenters enter the high pollution area 4 through the entrance door 51, the inner opening and closing door 33 between the first dressing room 31 and the clean area 2, the first dressing room 31, the inner opening and closing door 33 between the first dressing room 31 and the high pollution area 4, and then go out through the inner opening and closing door 33 between the second dressing room 32 and the high pollution area 4, the second dressing room 32, the inner opening and closing door 33 between the second dressing room 32 and the clean area 2, and the entrance door 51.

The first dressing room 31 is positioned in the inlet channel, and an experimenter can replace pollution-free protective clothing in the first dressing room 31; the second dressing room 32 is located in the exit passage, and the laboratory personnel can remove the contaminated protective suit from the second dressing room 32.

Optionally, the opening and closing manner of the inner opening and closing door 33 includes: any one or a plurality of combinations of zippers, magnetic attraction, adhesion, hooks and buckles are simple and convenient in opening and closing modes, so that an experimenter can be helped to rapidly open and close the inner opening and closing door 33, and the communication time between the buffer unit 3 and the clean area 2 and the communication time between the buffer unit 3 and the high-pollution area 4 are shortened.

Referring to fig. 2, an illumination lamp band 74 is provided in the functional space 19, and the illumination lamp band 74 is fixed to the inflatable membrane structure 1 by a velcro and/or a strap. In the embodiment shown in fig. 2, the illumination lamp strip 74 is configured as an arch-shaped lamp strip, and the arch-shaped lamp strip follows the inner surface of the inflatable membrane structure 1, whereby the aesthetic appearance of the illumination lamp strip 74 can be increased. In some embodiments, not shown, the illumination light strip 74 may also be configured in other shapes, such as a linear light strip, and extend along the length of the inflated membrane structure virus detection laboratory to increase the length of the illumination light strip 74 and expand the illumination range.

In some embodiments, the inflatable membrane structure 1 comprises an inflatable membrane dome structure, by which the functional space 19 is defined after inflation, and an inflatable membrane isolation structure, by which the cushioning unit 3 is defined. The gas film isolation structure and the gas film space 17 in the gas film dome structure can be connected or independent.

In the embodiment shown in fig. 1 and 4, the inflatable membrane dome structure comprises: a plurality of arched air-filled rings 14 which are closely arranged, wherein the air-filled rings 14 are air-filled rings 14 with positive pressure air film spaces 17 inside. In other words, the air film space 17 inside the air-filled ring 14 is a positive pressure environment, so that the air-filled ring 14 has a large hardness, and can play a supporting role to be supported outside the functional space 19, so that the space shape of the functional space 19 is maintained.

Referring to fig. 4, the inflation ring 14 includes an inner film 11 and an outer film 12, and a film space 17 is formed between the inner film 11 and the outer film 12. Preferably, the air film spaces 17 within each of the inflatable rings 14 are independent of each other, so that after one of the inflatable rings 14 is broken, the other inflatable rings 14 can continue to be used without having to replace the entire inflatable film structure 1 immediately, and the broken inflatable ring 14 can be repaired for continued use. Of course, the air film spaces 17 of the adjacent plurality of air-filled rings 14 may be communicated.

Further, the single-layer film 13 covers the inner side of the air-filled ring 14, the single-layer film 13 shields the air-filled ring 14 from the inner side, the inner surface of the single-layer film 13 is flat, and gaps between two adjacent air-filled rings 14 are avoided, so that the top of the functional space 19 is flat, the situation that the gaps between two adjacent air-filled rings 14 are exposed to cause poor appearance is avoided, and meanwhile, the single-layer film 13 can enable the dome structure of the air-filled film to have better sealing performance.

In the embodiment shown in fig. 5 (a), the inflatable membrane dome structure comprises: a support 15 positioned on the outer side and a single-layer film 13 positioned on the inner side, wherein a positive pressure-filled air film space 17 is formed between the single-layer film 13 and the support 15. The support 15 may be a multi-section support, the single-layer film 13 is attached to the edge of each section of support, and separated from the middle, and the gas is filled between the single-layer film 13 and each section of support, so that the inflatable film dome structure has heat preservation and heat insulation properties. Meanwhile, a plurality of air film spaces 17 are formed between the single-layer film 13 and each section of support frame, and when one air film space 17 is damaged, other air film spaces 17 can be normally used.

In the embodiment shown in fig. 5 (b), the inflatable membrane dome structure comprises: the support frame 15 that is located the outside and the bilayer membrane that is located the inboard, bilayer membrane are the bilayer membrane that has positive pressure air film space 17 inside, and support frame 15 restriction is in the outside of bilayer membrane, plays limiting displacement to the bilayer membrane.

The double-layer film includes an inner film 11 and an outer film 12, the outer film 12 being located outside the inner film 11, and a film space 17 being formed between the inner film 11 and the outer film 12. The support 15 may be a multi-section support, and the outer film 12 of the double-layer film is suitable for being attached to each section of support, and the double-layer film can enable the dome structure of the inflatable film to have heat preservation, heat insulation and other performances. Meanwhile, the air film spaces 17 can be divided into a plurality of air film spaces, and when one of the air film spaces 17 is damaged, the other air film spaces 17 can be normally used.

The supporting frame 15 may be a steel frame, or may be a frame structure such as a plastic frame or a composite material frame, which can play a supporting role.

In the embodiment shown in fig. 6-7, the inflatable membrane dome structure comprises: the support air column frame 16 is formed by constructing a plurality of support air columns 161 with positive pressure air film spaces 17 inside, and the outer side of the support air column frame 16 is covered with a single-layer film 13 or a double-layer film with the positive pressure air film spaces 17. The support air column frame 16 can play a role of supporting the single-layer film 13 or the double-layer film, and the outer side of the support air column frame 16 is covered with the single-layer film 13 or the double-layer film, so that the inflatable membrane dome structure has heat preservation, heat insulation and other performances, and has good sealing performance. In some embodiments, there are multiple support gas columns 161, and other support gas columns 161 may be used normally when one of the support gas columns 161 is damaged.

The inner film 11, the outer film 12, the single-layer film 13, and the support air column 161 may be made of the same film material.

Referring to fig. 1, 3-5, the inflatable membrane structure 1 has a membrane space 17, a membrane structure filling port and a membrane structure air outlet 18, wherein the membrane structure filling port and the membrane structure air outlet are communicated with the membrane space 17, and a blower is communicated with the membrane structure filling port and blows air into the membrane space 17, wherein the air inlet quantity at the membrane structure filling port is larger than the air outlet quantity at the membrane structure air outlet 18, so that the membrane space 17 is a positive pressure membrane space. The blower may be mounted on a blower housing 56 as shown in fig. 2, and the blower housing 56 may be fixedly connected to the inlet device housing 54 such that the blower housing 56 becomes part of the inlet device integrated module 5.

The film material of the inflatable film structure 1 mainly comprises glass fiber cloth, plastic film, metal braid and the like, wherein the glass fiber cloth is preferably used, and the surface of the glass fiber cloth can be coated with polytetrafluoroethylene and other coatings to improve durability and fire resistance. In addition, after the inflatable membrane structure 1 is inflated and supported, the interior of the inflatable membrane structure 1 may be coated with a building coating to enhance the stability and physical protection characteristics, improve the isolation strength, etc., for example, a polyurethane waterproof coating may be coated in the inflatable membrane structure 1 to enhance the waterproof property.

The inflated membrane structure 1 also has a better toughness to avoid easy breakage during installation or use. In addition, the inflatable membrane structure 1 can be transparent or can be in a dark color capable of being shielded so as to meet different requirements. In addition, the inflatable membrane structure 1 can flexibly select inflatable membranes with different thickness according to the isolation period of epidemic situation latency or the complexity of terrains.

In some embodiments, not shown, the inflatable membrane structure 1 includes an inner membrane, an outer membrane, and a gas membrane space is formed between the inner membrane and the outer membrane. The seams of the materials of the inner film and the outer film can be in three forms of welding, bonding and sewing. In some alternative embodiments, the air film space may be a complete sealed cavity; in other alternative embodiments, the air film space may be divided into a plurality of continuous sealed cavities; after one of the cavities is broken, the other cavities can still be used continuously without immediately replacing the whole inflatable membrane structure 1, and the broken cavity can be repaired so as to be used continuously. And the outer films corresponding to the sealing cavities are provided with air charging openings for pre-charging. In short, the double-layer structure 1 can enhance the protection of air tightness and improve the durability.

As shown in fig. 1, the air-filled rings 14 are provided with film structure air outlets 18, and each air-filled ring 14 has a film structure air outlet 18, or the plurality of air-filled rings 14 share the same film structure air outlet 18.

According to some embodiments of the present application, the high pollution zone 4 is provided with a humidifier to ensure that the humidity within the high pollution zone 4 meets the humidity requirement, i.e. to ensure that the humidity within the high pollution zone 4 is within the range required by the technical specifications.

According to some embodiments of the present application, one or more skylights are provided at the top of the high pollution area 4 for lighting or ventilation, and an inward unidirectional filter is provided at the skylights, only allowing outside air to enter the high pollution area 4 through the unidirectional filter, but not allowing air in the high pollution area 4 to escape outwards through the unidirectional filter, thereby effectively avoiding virus leakage in the high pollution area 4. In an actual scene, the lighting and ventilation requirements required for the highly polluted area 4 in the actual scene can be met through the skylight.

Referring to fig. 3, the high pollution area 4 has a first transfer port 41 and a second transfer port 42, and the transfer units are adapted to be disposed at the first transfer port 41 and the second transfer port 42.

Optionally, the transfer unit is a material transfer box and/or a personnel aisle box 45. The first transfer port 41 and the second transfer port 42 may be one or more, and the first transfer port 41 and the second transfer port 42 may be provided with a material transfer box or a personnel passage box 45, or both the material transfer box and the personnel passage box 45.

In the embodiment shown in fig. 3, the transfer unit is a material transfer box (e.g., intermediate material transfer box 43, feed transfer box 44) through which the sample or reagent, etc., may be transferred into the interior of the high contamination zone 4.

In some embodiments, not shown, the transfer unit is a personnel access box 45 for the ingress and egress of laboratory personnel.

In the embodiment shown in fig. 11, the transfer unit is a material transfer box and a personnel channel box 45, and samples or reagents and the like can be transferred into the high-pollution area 4 through the material transfer box, and can also be transferred into the high-pollution area 4 through the personnel channel box 45 by carrying samples or reagents and the like by an experimenter.

In some embodiments, the transfer unit and the garbage transfer box 61 all comprise an inner door facing the high pollution area 4 and an outer door facing the outside, and the transfer unit and the garbage transfer box 61 all adopt intelligent interaction technology, so that the inner door and the outer door form an intelligent interlocking structure, and the inner door and the outer door cannot be opened simultaneously, thereby ensuring that the positions of the transfer unit and the garbage transfer box 61 can play an isolating role, and the inner side of the inner door is not communicated with the outer side of the outer door, so as to ensure the use safety of the virus detection laboratory with the inflatable membrane structure. In some alternative embodiments, the intelligent interaction technology may be an optical interaction technology, so that the inner door and the outer door become optical interaction doors, and an opening or closing instruction is sent to the inner door and the outer door by adopting a mobile phone flashlight or a flashlight ring and the like. In other alternative embodiments, the inner door and the outer door may also be voice interaction doors, and voice instructions are used to open or close the inner door and the outer door. In this way, even when the experimenter wears the protective suit, the contact-free control of the transfer unit and the trash transfer box 61 can be realized without using the face scan.

In some embodiments, the inflatable membrane structure 1 can be folded for storage by venting gas. The inflatable membrane structure 1 has high volume compression ratio, can store a large number of folded inflatable membrane structures 1 in a limited space, can transport a large number of folded inflatable membrane structures 1 at one time, and is favorable for realizing quick construction of a laboratory. In the epidemic situation outbreak, the inflatable membrane structure virus detection laboratory can be used as a temporary building for emergency use near the epidemic situation outbreak area. After epidemic peak time, the inflatable membrane structure virus detection laboratory can pump out gas, and the inflatable membrane structure 1 is sterilized and recovered, so that the inflatable membrane structure is conveniently and subsequently transferred to a new address and then spliced again.

The outer surface of the inflatable membrane structure 1 can be subjected to performance upgrading or modification into a long-lasting building through any one or more of spraying building industrial materials, pouring concrete and covering vegetation.

Referring to fig. 3, 8-11, a biosafety laboratory according to an embodiment of a second aspect of the application includes: a plurality of inflatable membrane structured virus detection laboratories according to the embodiments of the first aspect of the present application, wherein the second transfer port 42 of one inflatable membrane structured virus detection laboratory is aligned with the first transfer port 41 of an adjacent one of the inflatable membrane structured virus detection laboratories and connected by a transfer unit.

In the embodiments shown in fig. 3, 8-10, the inflatable membrane structured virus detection laboratory is two, namely, the biosafety laboratory includes: the two inflatable membrane structure virus detection laboratories, the second transfer port 42 of the first inflatable membrane structure virus detection laboratory 10 is aligned with the first transfer port 41 of the second inflatable membrane structure virus detection laboratory 20, and the two are connected by a transfer unit. In the embodiment shown in fig. 3, the transfer unit between the second transfer port 42 of the first inflatable membrane structured virus detection laboratory 10 and the first transfer port 41 of the second inflatable membrane structured virus detection laboratory 20 is an intermediate transfer box 43. The intermediate transfer box 43 has a smaller size, so that the distance between two inflatable membrane structure virus detection laboratories can be as small as possible, thereby reducing the space occupied by the biosafety laboratory, facilitating the arrangement of a plurality of biosafety laboratories in a limited space, and further improving the daily detection amount.

The highly contaminated region 4 of the first air-filled membrane structured virus detection laboratory 10 is a sample receiving and preparing region to highly integrate functions of sample receiving, sample preparing, etc., and the highly contaminated region 4 of the second air-filled membrane structured virus detection laboratory 20 is an amplification region. In the embodiment shown in fig. 3, nucleic acid samples prepared by the sample receiving and preparation zone may be delivered to the amplification zone via the intermediate transfer box 43 without requiring an experimenter to enter the amplification zone from the sample receiving and preparation zone.

The first transfer port 41 of the first inflatable membrane structured virus detection laboratory 10 is a first sample inlet and the second transfer port 42 of the second inflatable membrane structured virus detection laboratory 20 is a second sample inlet. In the embodiment shown in fig. 3, the transfer units at the first sample inlet and the second sample inlet are feed transfer boxes 44. The material flow line of the biosafety laboratory is shown in fig. 10, and the sample collected in the sample collection area can be delivered into the first inflatable membrane structure virus detection laboratory 10 through the first sample inlet, as shown by the D1 flow line in fig. 10; reagents may be delivered into a second aerated film structured virus detection laboratory 20 via a second sample inlet, as shown by the D2 flow line in fig. 10; the material flow line at the intermediate transfer box 43 is shown as D3 flow line in fig. 10.

The feed transfer box 44 is configured as a sterile transfer box to enhance safety in use.

Referring to fig. 3, a sample inactivation area, a sample unpacking and information verification area, a sample tube transfer plate area and a sample preparation area are arranged in the high pollution area 4 of the first inflatable membrane structure virus detection laboratory 10 so as to meet the receiving and preparation flow of samples.

Further, a drying box 101 is arranged at the sample inactivation area, and samples are inactivated in the drying box 101; the sample unpacking and information verifying area is provided with a first biosafety cabinet 102, and unpacking and information verifying are carried out on the sample in the first biosafety cabinet 102; a second biosafety cabinet 103 is arranged at the sample tube rotating plate area, and the sample tube is rotated in the second biosafety cabinet 103; at the sample preparation area, a sample nucleic acid extractor 104 is provided for automated extraction of sample nucleic acids.

Optionally, any one or more combinations of a centrifuge 81, a refrigerator 82, a printer 83, and an oscillator 84 are also provided in the highly contaminated zone 4 of the first inflatable membrane structured virus detection laboratory 10. The centrifuge 81 may be any one or a combination of a plate centrifuge, a palm centrifuge, and a high-speed centrifuge.

Optionally, the drying oven 101 is positioned adjacent to the first sample inlet, whereby samples incoming from the first sample inlet may be placed in close proximity to the drying oven 101 for inactivation, reducing the residence time of non-inactivated samples within the first aerated film structure virus detection laboratory 10.

The second inflatable membrane structured virus detection laboratory 20 is provided with a nucleic acid amplification apparatus 201 in the highly contaminated region 4 to satisfy the amplification procedure of the sample. The nucleic acid amplification instrument 201 may be a fluorescent quantitative PCR instrument for performing exponential amplification of nucleic acids.

Optionally, any one or more of a centrifuge 81, a refrigerated cabinet 82, and an oscillator 84 are also provided in the highly contaminated zone 4 of the second inflatable membrane structured virus detection laboratory 20. The centrifuge 81 may be any one or a combination of a plate centrifuge, a palm centrifuge, and a high-speed centrifuge.

Centrifuge 81 may be used to centrifuge the sample, refrigerated cabinet 82 may refrigerated the sample, oscillator 84 may be used to oscillate the sample, and printer 83 may be used to print sample information, labels, etc.

Referring to fig. 3 and 9, the drying oven 101, the first biosafety cabinet 102, the second biosafety cabinet 103, the sample nucleic acid extractor 104, and the nucleic acid amplifier 201 are used in this order. The device usage flow line may be as shown by the C flow line in fig. 9.

Optionally, the high pollution areas 4 of the first and second inflatable membrane structure virus detection laboratories 10 and 20 are further provided with an autoclave 85 for sterilizing medical waste, and the sterilized waste is delivered to an external device for receiving the waste through the corresponding waste delivery box 61, so that the waste discharged from the biosafety laboratory is sterilized waste, and secondary pollution to the environment is prevented. The garbage flow lines at the garbage transfer box 61 are shown as E1 flow lines and E2 flow lines in fig. 10.

According to the biosafety laboratory of the embodiment of the second aspect of the application, the sample receiving and preparing area is separated from the amplifying area through the transfer unit, so that the use safety of the biosafety laboratory is improved, and once the diffused nucleic acid in the amplifying area leaks, the leaked nucleic acid can be prevented from entering the sample receiving and preparing area.

In the embodiment shown in fig. 11, the side of the first inflatable membrane structured virus detection laboratory 10 facing away from the second inflatable membrane structured virus detection laboratory 20 is provided with at least one first auxiliary inflatable membrane structured virus detection laboratory for assisting in the sample receiving and preparation process, such as laboratory 30;

The side of the second inflatable membrane structured virus detection laboratory 20 facing away from the first inflatable membrane structured virus detection laboratory 10 is provided with at least one second auxiliary inflatable membrane structured virus detection laboratory for auxiliary amplification procedures, such as laboratories 40, 50;

the first auxiliary inflatable membrane structured virus detection laboratory 30 and the second auxiliary inflatable membrane structured virus detection laboratory 40, 50 are both inflatable membrane structured virus detection laboratories. Material or personnel circulation can be realized between any two adjacent inflatable membrane structure virus detection laboratories through the intermediate material transfer box 43 and/or the personnel channel box 45.

Only the intermediate transfer box 43 may be provided between the first and second inflatable membrane structured virus detection laboratories 10 and 20, without the personnel access box 45, to reduce the experimenter's movement between the amplification zone of the second inflatable membrane structured virus detection laboratory 20 and the sample receiving and preparation zone of the first inflatable membrane structured virus detection laboratory 10.

And intermediate material transfer box 43 and personnel channel box 45 may be disposed between first inflatable membrane structure virus detection laboratory 10 and first auxiliary inflatable membrane structure virus detection laboratory 30, and intermediate material transfer box 43 and personnel channel box 45 may be disposed between second inflatable membrane structure virus detection laboratory 20 and second auxiliary inflatable membrane structure virus detection laboratory 40, 50.

An earthing structure virus-testing laboratory according to an embodiment of the third aspect of the present application, comprising: according to the inflatable membrane structure virus detection laboratory of the embodiment of the first aspect of the application, the outer surface of the inflatable membrane structure 1 is formed into a long-lasting earthing structure building by any one or more of spraying building industrial materials, pouring concrete and covering vegetation. The air-filled membrane structure virus detection laboratory is a single laboratory, and the earthing structure virus detection laboratory comprising the single air-filled membrane structure virus detection laboratory is also a single laboratory.

An earthing structure virus test laboratory according to an embodiment of the fourth aspect of the present application, comprising: as in the biosafety laboratory of the second aspect of the present application, the outer surface of the inflatable membrane structure 1 is formed into a long-lasting soil-covered structure by any one or more of spraying building industry materials, casting concrete, and covering vegetation. The biosafety laboratory is a plurality of laboratories, and the earthing structure virus detection laboratory comprising the biosafety laboratory is also a plurality of laboratories.

According to some embodiments of the present application, spraying or jetting of the outer surface of the inflatable membrane structure 1 may be accomplished using one or more of polyurethane spraying, steel fiber concrete spraying, EPS gypsum spraying, cement mortar spraying. Of course, other spraying means not mentioned in the present application may also be used to spray the outer surface of the inflatable membrane structure 1.

In addition, the people stream (A, B), the logistics (D1, D2 and D3) and the garbage streams (E1 and E2) are strictly separated, so that the use safety of the inflatable membrane structure virus detection laboratory, the biological safety laboratory and the earthing structure virus detection laboratory is improved.

In the description of the present specification, a description referring to the terms "one embodiment," "some embodiments," "examples," "particular examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Further, one skilled in the art can engage and combine the different embodiments or examples described in this specification.

Although embodiments of the present application have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the application, and that variations, modifications, alternatives, and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the application.

Claims (45)

1. A gas-filled membrane structured virus detection laboratory comprising: an inflatable membrane structure (1) inflatable to form a house or a tubular body;

the inflatable membrane structure (1) can form a functional space (19) after being inflated, the functional space (19) is internally provided with a clean area (2), one or more buffer units (3) used as auxiliary functional areas and a high pollution area (4) used as main functional areas, the buffer units (3) are defined by the inflatable membrane structure (1), the buffer units (3) separate the clean area (2) from the high pollution area (4), and the buffer units (3) are provided with inner opening and closing doors (33) which are hermetically separated or communicated with the clean area (2) and the high pollution area (4), the inflatable membrane structure (1) comprises an inflatable membrane dome structure and an inflatable membrane isolation structure, the functional space (19) is defined by the inflatable membrane dome structure after being inflated, the buffer units (3) are defined by the inflatable membrane isolation structure, and the inflatable membrane structure comprises: a support frame (15) positioned on the outer side and a single-layer film (13) positioned on the inner side, wherein the single-layer film (13) is suitable for forming a positive pressure filled air film space (17) with the support frame (15);

An inlet equipment integration module (5), the inlet equipment integration module (5) being arranged at one end of the functional space (19) and comprising at least an inlet door (51), the inlet door (51) being hermetically isolated or in communication with the clean zone (2);

an outlet device integration module (6), the outlet device integration module (6) being arranged at the other end of the functional space (19) and comprising at least a waste transfer bin (61);

at least one of the inlet equipment integration module (5) and the outlet equipment integration module (6) further comprises a bi-directional heat exchange fresh air fan with a filtering device, the bi-directional heat exchange fresh air fan being used for delivering gas to the functional space (19) or extracting gas from the functional space (19);

by means of the bidirectional heat exchange fresh air fan, the high pollution area (4) can be made to be a negative pressure environment.

2. The inflatable membrane structured virus detection laboratory according to claim 1, wherein the buffer unit (3) and the clean zone (2) are both in a negative pressure environment, and the pressure relationship of the clean zone (2), the buffer unit (3), the high pollution zone (4) is: said clean zone (2) > said buffer unit (3) > said high contamination zone (4).

3. The aerated film structured virus detection laboratory of claim 2, further comprising: and at least one air column air pipe (71) with one end extending into the functional space (19), and the other end of the air column air pipe (71) is connected with the corresponding bidirectional heat exchange fresh air fan.

4. A laboratory for detecting viruses with an inflatable membrane structure according to claim 3, characterized in that the air column air duct (71) is provided with a first air duct opening communicated with the clean zone (2), a second air duct opening communicated with the buffer unit (3) and a third air duct opening communicated with the high pollution zone (4).

5. The inflated membrane structure virus detection laboratory of claim 1 wherein said bi-directional heat exchange fresh air mover comprises: an inlet-side bidirectional heat exchange fresh air fan (52) belonging to the inlet equipment integrated module (5) and an outlet-side bidirectional heat exchange fresh air fan (62) belonging to the outlet equipment integrated module (6).

6. The inflatable membrane structured virus-detection laboratory according to claim 5, wherein at least one of said inlet device integration module (5) and said outlet device integration module (6) further comprises an air-conditioning outdoor unit, and wherein an air-conditioning indoor unit (72) is provided in said functional space (19).

7. The inflatable membrane structured virus detection laboratory according to claim 6, wherein said air conditioning outdoor unit comprises: an inlet-side air-conditioning outdoor unit (53) belonging to the inlet-device integrated module (5) and an outlet-side air-conditioning outdoor unit (63) belonging to the outlet-device integrated module (6).

8. The inflated membrane structure virus detection laboratory of claim 7 wherein said inlet device integration module (5) further comprises: and an inlet equipment frame (54), wherein the inlet side air conditioner outdoor unit (53) and the inlet side bidirectional heat exchange fresh air fan (52) are arranged on the inlet equipment frame (54).

9. The inflated membrane structure virus detection laboratory of claim 8 wherein said inlet device integration module (5) further comprises: -a disinfection tank (55), said disinfection tank (55) being placed on said inlet equipment rack (54).

10. The inflated membrane structure virus detection laboratory according to claim 1 wherein said access door (51) is an intelligent interactive access door and said access door (51) is opened and closed in a non-contact manner.

11. The inflated membrane structure virus detection laboratory of claim 7 wherein said outlet device integration module (6) further comprises: and the garbage transfer box (61), the outlet side air conditioner outdoor unit (63) and the outlet side bidirectional heat exchange fresh air fan (62) are arranged on the outlet equipment frame (64).

12. The inflated membrane structure virus detection laboratory of claim 1 wherein said outlet device integration module (6) further comprises: the fire escape emergency door (65), wherein the fire escape emergency door (65) is in airtight partition or communication with the high pollution area (4).

13. The aerated film structured virus detection laboratory according to claim 1, characterized in that at least one of the clean zone (2), the buffer unit (3), the high pollution zone (4) is provided with a smoke alarm system.

14. The inflatable membrane structured virus detection laboratory according to claim 1, wherein at least one of said clean zone (2), said buffer unit (3), said high pollution zone (4) is provided with a dry powder fire extinguisher.

15. The inflated membrane structure virus detection laboratory according to claim 1 wherein one or more air disinfection devices (73) are provided within said high contamination zone (4), said air disinfection devices (73) comprising: any one or more of a plasma sterilizer, an ultraviolet ozone generator and a dry fog type hydrogen peroxide sterilizer.

16. The inflated membrane structure virus detection laboratory according to claim 1 wherein said buffer unit (3) comprises: -a first dressing room (31) and a second dressing room (32) independent from each other, both the first dressing room (31) and the second dressing room (32) having the inner opening and closing door (33).

17. The inflatable membrane structured virus-detection laboratory according to claim 16, wherein an inlet channel is formed between the inlet door (51), the inner opening and closing door (33) between the first dressing room (31) and the clean zone (2), the inner opening and closing door (33) between the first dressing room (31) and the high-pollution zone (4), the inner opening and closing door (33) between the second dressing room (32) and the clean zone (2), and an outlet channel is formed between the inlet door (51).

18. The inflated membrane structure virus detection laboratory of claim 1 wherein the manner of opening and closing the inner opening and closing door (33) comprises: any one or a combination of a plurality of zippers, magnetic attraction, adhesion, hooks and buckles.

19. The inflatable membrane structure virus-detection laboratory according to claim 1, characterized in that an illumination lamp belt (74) is arranged in the functional space (19), and the illumination lamp belt (74) is fixed on the inflatable membrane structure (1) through a magic tape and/or a binding belt.

20. The inflated membrane structure virus detection laboratory of claim 1 wherein said inflated membrane dome structure comprises: the inflatable ring (14) is a plurality of arched inflatable rings (14) which are closely arranged, and the inflatable rings (14) are inflatable rings (14) with positive pressure air film spaces (17) inside.

21. The inflated membrane structure virus detection laboratory of claim 20 wherein the inside of the inflated ring (14) is covered with a single layer membrane (13).

22. The inflated membrane structure virus detection laboratory of claim 20 wherein said inflated membrane dome structure comprises: the double-layer membrane is positioned on the inner side, and the double-layer membrane is provided with a positive pressure air film space (17) inside.

23. The inflated membrane structure virus detection laboratory of claim 1 wherein said inflated membrane dome structure comprises: the support air column frame (16), support air column frame (16) are built by many support air columns (161) that have positive pressure air film space (17) inside, just the outside of support air column frame (16) covers monolayer film (13) or has the bilayer film of positive pressure air film space (17).

24. The gas-filled membrane structure virus detection laboratory according to claim 1, wherein the gas-filled membrane structure (1) is provided with a gas membrane space (17), a membrane structure filling port communicated with the gas membrane space (17) and a membrane structure air outlet (18), a blower is communicated with the membrane structure filling port and blows air into the gas membrane space (17), and the air inlet quantity at the membrane structure filling port is larger than the air outlet quantity at the membrane structure air outlet (18) so that the gas membrane space (17) is a positive pressure gas membrane space.

25. The aerated film structured virus detection laboratory according to claim 1, characterized in that the highly contaminated zone (4) is provided with a humidifier to meet humidity requirements; and/or one or more skylights are arranged at the top of the high pollution area (4) and used for lighting or ventilation, and an inward unidirectional filter device is arranged at the skylights.

26. The aerated film structured virus detection laboratory of any of claims 1-25, wherein the high-pollution zone (4) has a first transfer port (41) and a second transfer port (42), the first transfer port (41) and the second transfer port (42) being adapted for the provision of a transfer unit.

27. The inflatable membrane structured virus detection laboratory according to claim 26, wherein said transfer unit is a material transfer box and/or a personnel aisle box.

28. The inflatable membrane structured virus-detection laboratory according to claim 27, wherein said transfer unit and said waste transfer bin (61) each comprise an inner door facing said high-pollution area (4) and an outer door facing the outside, said transfer unit and said waste transfer bin (61) each employ intelligent interaction techniques to form an intelligent interlocking structure with said inner door and said outer door to ensure that said inner door and said outer door cannot be opened simultaneously.

29. The inflatable membrane structure virus-detection laboratory according to claim 27, wherein said inflatable membrane structure (1) is foldable by pumping out gas.

30. The inflatable membrane structure virus-detection laboratory according to claim 27, wherein the outer surface of the inflatable membrane structure (1) can be upgraded or retrofitted to permanent buildings by any one or a combination of spraying building industry materials, casting concrete, and covering vegetation.

31. A biosafety laboratory comprising: a plurality of the inflatable membrane structured virus detection laboratories of any one of claims 26 to 30, wherein the second transfer port (42) of one of the inflatable membrane structured virus detection laboratories is aligned with the first transfer port (41) of an adjacent one of the inflatable membrane structured virus detection laboratories and connected by the transfer unit.

32. Biosafety laboratory according to claim 31, characterized in that the number of said inflatable membrane structured virus detection laboratories is two, the second transfer port (42) of the first inflatable membrane structured virus detection laboratory (10) being aligned with the first transfer port (41) of the second inflatable membrane structured virus detection laboratory (20) and connected by said transfer unit.

33. Biosafety laboratory according to claim 32, characterized in that said highly contaminated zone (4) of said first aerated film structured virus detection laboratory (10) is a sample receiving and preparation zone and said highly contaminated zone (4) of said second aerated film structured virus detection laboratory (20) is an amplification zone.

34. The biosafety laboratory of claim 33, wherein a first transfer port (41) of said first inflatable membrane structured virus detection laboratory (10) is a first sample inlet and a second transfer port (42) of said second inflatable membrane structured virus detection laboratory (20) is a second sample inlet.

35. The biosafety laboratory according to claim 34, characterized in that said high-pollution area (4) of said first inflatable membrane structured virus detection laboratory (10) is provided with a sample inactivation area, a sample unpacking and information verification area, a sample tube transfer plate area, a sample preparation area, to satisfy the receiving and preparation procedures of the samples.

36. Biosafety laboratory according to claim 35, characterized in that a drying oven (101) is provided at the sample inactivation zone, the sample being inactivated inside the drying oven (101); the sample unpacking and information verifying area is provided with a first biosafety cabinet (102), and unpacking and information verifying are carried out on the sample in the first biosafety cabinet (102); a second biosafety cabinet (103) is arranged at the sample tube rotating plate area, and the sample tube is rotated in the second biosafety cabinet (103); a sample nucleic acid extractor (104) is disposed at the sample preparation zone for automated extraction of sample nucleic acids.

37. Biosafety laboratory according to claim 32 or 36, characterized in that said first aerated film structured virus detection laboratory (10) is further provided with any one or more combinations of centrifuges (81), refrigerated cabinets (82), printers (83), oscillators (84) within said high-pollution zone (4).

38. Biosafety laboratory according to claim 36, characterized in that the drying oven (101) is arranged adjacent to the first sample inlet.

39. The biosafety laboratory according to claim 36, characterized in that a nucleic acid amplification instrument (201) is disposed in said highly contaminated zone (4) of said second inflatable membrane structured virus detection laboratory (20) to satisfy an amplification procedure of a sample.

40. The biosafety laboratory according to claim 32 or 39, characterized in that said second aerated film structured virus detection laboratory (20) further comprises any one or more combinations of a centrifuge (81), a refrigerated cabinet (82), and an oscillator (84) within said high-pollution zone (4).

41. The biosafety laboratory according to claim 39, characterized in that said drying oven (101), said first biosafety cabinet (102), said second biosafety cabinet (103), said sample nucleic acid extractor (104), said nucleic acid amplifier (201) are used in sequence.

42. Biosafety laboratory according to claim 32, characterized in that an autoclave (85) for sterilizing medical waste is also provided in the high-pollution zone (4) of the first and second inflatable membrane structured virus detection laboratories (10, 20).

43. The biosafety laboratory according to claim 33, characterized in that a side of said first inflatable membrane structured virus detection laboratory (10) facing away from said second inflatable membrane structured virus detection laboratory (20) is provided with at least one first auxiliary inflatable membrane structured virus detection laboratory for auxiliary sample receiving and preparation procedures;

one side of the second inflatable membrane structure virus detection laboratory (20) away from the first inflatable membrane structure virus detection laboratory (10) is provided with at least one second auxiliary inflatable membrane structure virus detection laboratory for auxiliary amplification flow;

the first auxiliary inflatable membrane structure virus detection laboratory and the second auxiliary inflatable membrane structure virus detection laboratory are both the inflatable membrane structure virus detection laboratory.

44. A soil-covered structure virus detection laboratory, comprising: the aerated film structure virus detection laboratory of any of claims 1-30, wherein the aerated film structure (1) exterior surface is formed into a permanent covered structure by any one or more of spraying building industry materials, casting concrete, and covering vegetation.

45. A soil-covered structure virus detection laboratory, comprising: the biosafety laboratory of any one of claims 31-43, said inflatable membrane structure (1) outer surface being formed into a permanent covered earth structure building by any one or more of spraying building industry materials, casting concrete, and covering vegetation.

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