CN112618013A - Photo-thermal treatment system based on temperature and image dual-mode monitoring and feedback - Google Patents
Photo-thermal treatment system based on temperature and image dual-mode monitoring and feedback Download PDFInfo
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Abstract
The invention provides a photothermal therapy system based on temperature and image dual-mode monitoring and feedback, which can carry out range-controllable accurate laser irradiation on a tissue to be treated, and comprises a control feedback module, a photothermal therapy module and a temperature monitoring module, wherein the photothermal therapy module is connected with the control feedback module; the photothermal therapy module irradiates the tissue to be treated with laser to heat the tissue; the control feedback module acquires infrared thermal imaging of the tissue to be processed through the temperature monitoring module so as to evaluate whether a temperature rise range formed by current laser irradiation is within a preset threshold temperature range of the tissue to be processed and whether the temperature born by the tissue receiving laser irradiation meets a preset value; the invention can monitor important parameters in the photo-thermal treatment process and can carry out feedback by combining temperature monitoring and image monitoring.
Description
Technical Field
The invention relates to the technical field of biomedicine and optics, in particular to a photo-thermal treatment system based on temperature and image dual-mode monitoring and feedback.
Background
Photothermal therapy is a tumor thermotherapy technique that utilizes local biological tissue to be heated to solidify and necrose lesion tissue (cancer cell tissue). The basic process is that the probe with pore canal is led into the tissue to be treated or tumor tissue through percutaneous puncture, the tissue is irradiated by laser, the tissue absorbs light energy and converts the light energy into heat energy to diffuse to the surrounding tissue, the temperature of the tissue is continuously raised, and the tumor target tissue generates thermal coagulation necrosis, and the main process is the photothermal response of the tissue. When the tumor is treated by photo-thermal treatment, the temperature generated by the photo-thermal effect directly damages and destroys tumor cells. When the photothermal therapy is performed, even if the light source is directed to the lesion region, the heat accumulated on the lesion region is still dispersed and transferred to another part of the tissue body by the photothermal conversion effect. Therefore, regardless of whether the tissue is diseased or not, the tissue is thermally damaged to some extent after being exposed to a temperature exceeding the effective range for a certain period of time. It can thus be seen that temperature is a central parameter in photothermal therapy. The current parameter control of photothermal therapy is set by the experience value of a doctor, and when the laser dose is small, the effect on the therapy is not achieved; and when the laser dose is large, normal tissues can be damaged. Therefore, monitoring the dynamic changes in temperature during photothermal therapy in real time plays an important role in therapy control.
The infrared imager monitors the temperature without entering the tissue, has the characteristics of non-invasion, quick imaging, visual image and the like, has the nondestructive detection characteristic which is favorable for detecting the temperature under the condition of not damaging the tissue, and is undoubtedly a good choice in the application of photothermal therapy. In the case of monitoring the temperature, if the laser power can be adjusted according to the temperature to keep the temperature at a constant desired value, the photo-thermal damage of the desired temperature value can be simulated. Therefore, in the invention, the power is adjusted by combining a PID controller and a thermal infrared imager to design a temperature feedback type laser power adjusting system to obtain the photo-thermal effect corresponding to the expected temperature.
In the treatment process, not only the monitoring of the temperature field is important, but also the non-invasive monitoring of the image is particularly important. The currently used nondestructive detection technology is beneficial and has disadvantages. Magnetic Resonance Imaging (MRI), which is clear and has good resolution, but has poor effect when used for real-time detection, is not cheap, and may not be used for some patients; computed Tomography (CT) images have high resolution and low price, but have side effects on the human body. In recent years, Optical Coherence Tomography (OCT) technology has advanced significantly as a new imaging modality, and still has a good development space. As an imaging technique which is free from contact, causes no wound, and is inexpensive, its resolution is excellent, and it is possible to realize depth imaging for a medium such as a tissue or organ which has a strong scattering action. We therefore attempt to use OCT imaging techniques to assist in the reconstruction of internal and external images to help visualize the extent of tissue damage.
Disclosure of Invention
The invention provides a photothermal therapy system based on temperature and image dual-mode monitoring and feedback, which can monitor important parameters in the photothermal therapy process and can carry out feedback by combining temperature monitoring and image monitoring.
The invention adopts the following technical scheme.
A photothermal therapy system based on temperature and image dual-mode monitoring and feedback can carry out range-controllable accurate laser irradiation on a tissue to be treated, and comprises a control feedback module (4), a photothermal therapy module (1) connected with the control feedback module, and a temperature monitoring module (2) capable of carrying out infrared imaging; the photothermal therapy module irradiates the tissue to be treated with laser to heat the tissue; the control feedback module acquires infrared thermal imaging of the tissue to be processed through the temperature monitoring module so as to evaluate whether a temperature rise range formed by current laser irradiation is within a preset threshold temperature range of the tissue to be processed and whether the temperature bearable by the tissue receiving laser irradiation meets a preset value.
The photothermal therapy system further comprises an OCT image monitoring module (3) capable of three-dimensional imaging; the control feedback module acquires the image of the tissue to be processed through the OCT image monitoring module.
The control feedback module images the heated tissue to be processed through the OCT image monitoring module and reconstructs a three-dimensional image so as to acquire state change information of the surface and the interior of the tissue to be processed during irradiation and monitor whether the tissue to be processed is damaged by light and heat during irradiation.
The temperature monitoring module comprises a thermal infrared imager (201); the photothermal treatment module comprises a first laser (101), a first collimator (102) and an optical fiber treatment head (103) which are sequentially arranged on a laser light path of the photothermal treatment module; the laser of the first laser irradiates the tissue to be processed after passing through the first collimator and the optical fiber treatment head.
When the optical fiber treatment head irradiates the tissue to be treated, the distance between the optical fiber treatment head and the tissue is 2 cm; the thermal infrared imager is fixed by an optical support, and the detection direction of the thermal infrared imager forms an oblique angle of 45 degrees with the irradiation part of the photothermal treatment module.
The light source of the OCT image monitoring module is a second laser (301), and laser emitted by the second laser is emitted to the reference arm light path and the sample arm light path after passing through an isolator (302) and a fiber coupler (303); the laser entering the reference arm light path is emitted to a plane mirror (305) through a second collimator (304) in the reference arm light path, and then is reflected back to the optical fiber coupler by the plane mirror to form first return light; the laser entering the sample arm light path irradiates the tissue to be treated subjected to laser irradiation by the photothermal therapy module after passing through a third collimator (306), a reflecting mirror (307), a lens (308) and a scanning galvanometer (309) of the sample arm light path, and the reflected light forms second return light at the optical fiber coupler; the first return light and the second return light are output to a spectrometer (310) through coherent light formed at the optical fiber coupler; the control feedback module receives spectrometer data through a data acquisition card (311).
The optical fiber coupler is a 2 x 2 coupler with a splitting ratio of 50: 50; the photothermal treatment system also comprises a numerical control sample table (5) for placing tissues to be treated; the numerical control sample stage is a three-axis electric precise electric control translation stage and can carry out three-dimensional adjustment on the position and the posture of the placed tissue to be processed.
The control feedback module acquires optical data of the OCT image monitoring module through a data acquisition card, and acquires temperature detection data of the thermal infrared imager through the data acquisition card; the control feedback module controls the energy output of the first laser and the working states of the scanning galvanometer and the numerical control sample table according to the optical data and the temperature detection data, so that the temperature change caused by the irradiation of the laser to the tissue to be treated is kept within the set threshold range.
The control feedback module comprises a numerical control workstation, temperature data is processed by utilizing computer resources, the temperature of an irradiated tissue is kept within a threshold range by adjusting laser power, a three-dimensional image of the irradiated tissue is reconstructed by processing optical data of a data acquisition card through an Amira three-dimensional reconstruction algorithm, the damage range of photothermal therapy is divided, the functions of transmitting system data and controlling each instrument in the photothermal therapy system are realized through an RS-232 interface, and the control function of a LabVIEW compiling system is realized by using a virtual instrument technology, wherein the control function comprises the functions of realizing basic control function of laser, reading the temperature in real time, adjusting the laser power in real time and displaying the data in a visual mode, and realizing the function of feedback control through a PID controller.
In order to prevent the radiance deviation caused by light reflection, thermal focusing and thermal diffusion effect when the laser irradiates the tissue from influencing the temperature measurement precision of the thermal infrared imager, the thermal infrared imager corrects the radiance deviation when the photothermal therapy system measures the temperature by correcting calibration operation,
the method for correcting the calibration operation comprises the following steps;
step S1, after the water surface is irradiated by laser with preset power for ten minutes, the irradiated area of the water surface is measured by a thermocouple, a thermometer and a thermal infrared imager respectively to obtain water temperature change data;
step S2, irradiating the isolated tissue similar to the tissue to be processed for ten minutes by using laser with preset power, and then measuring the temperature of the irradiated area of the isolated tissue by using a thermocouple and a thermal infrared imager respectively to obtain tissue temperature change data;
and S3, correcting and calibrating the thermal infrared imager according to the water temperature change data and the tissue temperature change data.
In the invention, the sample platform for placing the sample is driven by the three-axis electric precise electric control translation table to perform two-dimensional scanning, thereby achieving the effect of three-dimensional scanning.
The invention utilizes PID (proportion probability; Integral Derivative) combined with a treatment system and a temperature monitoring system to feed back treatment effect in real time and adjust the output of the energy of a first laser, and the PID feedback used by the temperature feedback system comprises the steps of realizing the output feedback of laser energy combined with the power regulation of the laser, the temperature monitoring of a thermal infrared imager and a PID algorithm. When the tissue temperature monitored by the control system exceeds the set temperature, the treatment system automatically adjusts the dosage of the laser.
The invention has the beneficial effects that: realize the integration of photothermal therapy, temperature monitoring and image monitoring. The temperature and the form change in the treatment process can be synchronously detected in real time from the temperature and image angles. The detected temperature and image information are fed back to the PID system to adjust the treatment parameters, so as to achieve the purpose of real-time personalized treatment. The method can be applied to photodynamic therapy, photoimmunotherapy, etc.
The invention also has the following beneficial effects: a real-time monitoring and feedback system for dual-mode precise treatment based on temperature and images is constructed. The system integrates treatment, temperature and image dual-mode monitoring and feedback control, optimizes various parameter indexes in practical application, and finally can realize accurate treatment of in-situ tumor photothermal treatment, thereby effectively controlling the aim of remote tumor metastasis.
The invention provides a real-time monitoring and feedback system of a visual temperature image for photothermal therapy. The system can obtain the dynamic temperature change (accurate to 0.1 ℃) and the three-dimensional image in the photothermal treatment process in real time, and can display the damage degree in the treatment process. The parameter of real-time supervision feedback adjustment light and heat treatment can be reached, the light and heat treatment of tumour tissue provides accurate treatment monitored control system.
Drawings
The invention is described in further detail below with reference to the following figures and detailed description:
FIG. 1 is a schematic diagram of the structural principle of the present invention;
FIG. 2 is a schematic diagram of three-dimensional imaging of an OCT image monitoring module;
FIG. 3 is a schematic thermal imaging diagram of a thermal infrared imager for temperature feedback;
FIG. 4 is a schematic diagram of a control panel of the control feedback module of the present invention;
in the figure: 1-a photothermal therapy module; 2-a temperature monitoring module; 3-OCT image monitoring module; 4-control the feedback module; 5-numerical control sample stage;
101-a first laser; 102-a first collimator; 103-optical fiber treatment head;
201-infrared thermal imaging system;
301-a second laser; 302-an isolator; 303-fiber coupler; 304-a second collimator; 305-a plane mirror; 306-a third collimator; 307-mirror; 308-a lens; 309-scanning galvanometer; 310-a spectrometer; 311-a data acquisition card;
401-numerical control workstation.
Detailed Description
As shown in the figure, the photothermal therapy system based on dual-mode monitoring and feedback of temperature and images can carry out range-controllable precise laser irradiation on tissues to be treated, and comprises a control feedback module 4, a photothermal therapy module 1 connected with the control feedback module, and a temperature monitoring module 2 capable of carrying out infrared imaging; the photothermal therapy module irradiates the tissue to be treated with laser to heat the tissue; the control feedback module acquires infrared thermal imaging of the tissue to be processed through the temperature monitoring module so as to evaluate whether a temperature rise range formed by current laser irradiation is within a preset threshold temperature range of the tissue to be processed and whether the temperature bearable by the tissue receiving laser irradiation meets a preset value.
The photothermal therapy system further comprises an OCT image monitoring module 3 capable of three-dimensional imaging; the control feedback module acquires the image of the tissue to be processed through the OCT image monitoring module.
The control feedback module images the heated tissue to be processed through the OCT image monitoring module and reconstructs a three-dimensional image so as to acquire state change information of the surface and the interior of the tissue to be processed during irradiation and monitor whether the tissue to be processed is damaged by light and heat during irradiation.
The temperature monitoring module comprises a thermal infrared imager 201; the photothermal treatment module comprises a first laser 101, a first collimator 102 and an optical fiber treatment head 103 which are sequentially arranged on a laser light path of the photothermal treatment module; the laser of the first laser irradiates the tissue to be processed after passing through the first collimator and the optical fiber treatment head.
When the optical fiber treatment head irradiates the tissue to be treated, the distance between the optical fiber treatment head and the tissue is 2 cm; the thermal infrared imager is fixed by an optical support, and the detection direction of the thermal infrared imager forms an oblique angle of 45 degrees with the irradiation part of the photothermal treatment module.
The light source of the OCT image monitoring module is a second laser 301, and laser emitted by the second laser is emitted to a reference arm light path and a sample arm light path after passing through an isolator 302 and an optical fiber coupler 303; the laser entering the reference arm optical path is emitted to the plane mirror 305 through the second collimator 304 in the reference arm optical path, and then is reflected back to the optical fiber coupler by the plane mirror to form a first return light; the laser entering the sample arm light path irradiates the tissue to be treated subjected to laser irradiation by the photothermal therapy module after passing through a third collimator 306, a reflecting mirror 307, a lens 308 and a scanning galvanometer 309 of the sample arm light path, and the reflected light forms second return light at the optical fiber coupler; the first return light and the second return light form coherent light at the fiber coupler and are output to the spectrometer 310; the control feedback module receives spectrometer data via a data acquisition card 311.
The optical fiber coupler is a 2 x 2 coupler with a splitting ratio of 50: 50; the photothermal treatment system also comprises a numerical control sample table 5 for placing tissues to be treated; the numerical control sample stage is a three-axis electric precise electric control translation stage and can carry out three-dimensional adjustment on the position and the posture of the placed tissue to be processed.
The control feedback module acquires optical data of the OCT image monitoring module through a data acquisition card, and acquires temperature detection data of the thermal infrared imager through the data acquisition card; the control feedback module controls the energy output of the first laser and the working states of the scanning galvanometer and the numerical control sample table according to the optical data and the temperature detection data, so that the temperature change caused by the irradiation of the laser to the tissue to be treated is kept within the set threshold range.
The control feedback module comprises a numerical control workstation 401, temperature data is processed by computer resources, the temperature of an irradiated tissue is kept within a threshold range by adjusting laser power, a three-dimensional image of the irradiated tissue is reconstructed by processing optical data of a data acquisition card through an Amira three-dimensional reconstruction algorithm, the damage range of photothermal therapy is divided, the functions of transmitting system data and controlling each instrument in the photothermal therapy system are realized through an RS-232 interface, and the control function of a LabVIEW compiling system is realized by using a virtual instrument technology, wherein the control function comprises the functions of realizing basic control function of laser, reading the temperature in real time, adjusting the laser power in real time and displaying the data in a visual mode, and realizing the function of feedback control through a PID controller.
In order to prevent the radiance deviation caused by light reflection, thermal focusing and thermal diffusion effect when the laser irradiates the tissue from influencing the temperature measurement precision of the thermal infrared imager, the thermal infrared imager corrects the radiance deviation when the photothermal therapy system measures the temperature by correcting calibration operation,
the method for correcting the calibration operation comprises the following steps;
step S1, after the water surface is irradiated by laser with preset power for ten minutes, the irradiated area of the water surface is measured by a thermocouple, a thermometer and a thermal infrared imager respectively to obtain water temperature change data;
step S2, irradiating the isolated tissue similar to the tissue to be processed for ten minutes by using laser with preset power, and then measuring the temperature of the irradiated area of the isolated tissue by using a thermocouple and a thermal infrared imager respectively to obtain tissue temperature change data;
and S3, correcting and calibrating the thermal infrared imager according to the water temperature change data and the tissue temperature change data.
In this example, the three-axis electric precise electric control translation stage drives the sample platform for placing the sample to perform two-dimensional scanning, thereby achieving the effect of three-dimensional scanning.
The working process of the embodiment is as follows: light emitted by the first laser 101 enters the sample 501 through the optical fiber treatment head 103 after passing through the first collimator 102; a light beam emitted by the second laser 301 enters the optical fiber coupler 303 after passing through the isolator 302, the light beam is divided into a reference arm and a sample arm by the optical fiber coupler 303, the light in the light path of the reference arm passes through the second collimator 304 and then is reflected by the plane mirror 305 and returns to the optical fiber coupler 303 along the original path, the light in the light path of the sample arm sequentially passes through the third collimator 306 and the reflecting mirror 307 and then enters the scanning galvanometer 309 after being focused by the lens 308, and then is incident on a sample to be detected on the numerical control three-dimensional sample stage 501, the light returned from the sample to be detected and the reference light returned from the light path of the reference arm through the plane mirror 305 along the original path are coherent at the optical fiber coupler 303, then the coherent light is received by the spectrometer 310, and then the data; the thermal infrared imager 201 detects the sample stage 501 obliquely at 45 degrees to obtain the temperature of the surface of the sample. The power control of the first laser 101, the OCT image display and analysis of the acquisition card 311 and the temperature display of the thermal infrared imager 201 are all analyzed and processed by the control and processing module 4, the control and processing module 4 establishes a PID feedback system to feed back the dynamic change of the temperature in the treatment process in real time, and when the threshold value is reached, the laser parameters of the first laser 101 are adjusted. Accurate treatment and tracking feedback of photothermal treatment are realized through the control processing module 4.
The first embodiment is as follows:
in this example, a mouse tumor part is used as an experimental object of the system, and the photothermal therapy system based on dual-mode monitoring and feedback of temperature and image in this example comprises a control and processing module 4, a photothermal therapy module 1, a temperature monitoring module 2, an OCT image monitoring module 3 and a numerical control sample stage 5;
in the photothermal therapy module, a light source with 808nm of a semiconductor laser is used as an output light source of a first laser 101, and the light source is obliquely incident to a mouse tumor part on a sample table 501 through a first collimator 102 and an optical therapy head 103;
in the OCT image monitoring module, a 1310nm scanning light source is used as a light beam emitted by a second laser 301, the light beam emitted by the scanning light source enters an optical fiber coupler 303 after passing through an isolator 302, the light beam is divided into a reference arm and a sample arm by the optical fiber coupler 303, the light in the light path of the reference arm returns to the optical fiber coupler 303 along the original path after passing through a second collimator 304 and being reflected by a plane mirror 305, the light in the light path of the sample arm sequentially passes through a third collimator 306 and a reflecting mirror 307, is focused by a lens 308 and then enters a scanning galvanometer 309, and then is incident on the mouse tumor position on a numerical control three-dimensional sample stage 501, the light returning from the mouse tumor position and the reference light returning from the light path of the reference arm through the plane mirror 305 along the original path are coherent at the optical fiber coupler 303, and then the coherent light is received by a spectrometer 310, and the data acquisition; meanwhile, the thermal infrared imager 201 detects the skin position of the mouse at an angle of 45 degrees to obtain the temperature of the skin surface; the control and processing module 4 controls the power output of the semiconductor laser, controls the scanning galvanometer 309 to determine the scanning range of the OCT image, controls the numerical control three-dimensional sample stage 501 to realize three-dimensional scanning of the skin of the mouse, obtains the three-dimensional image of the skin of the mouse, as shown in figure 2, and simultaneously, collects the tissue temperature through the infrared thermal imager, as shown in figure 3,
processing the temperature data with computer resources and maintaining the irradiated tissue temperature within a threshold range by adjusting the laser power. The functions of system data transmission and instrument control are realized through an RS-232 interface, the control functions of a LabVIEW compiling system are realized by using a virtual instrument technology, as shown in FIG. 4, the functions of realization of a laser basic control function, real-time reading of temperature, real-time adjustment of laser power and visual display of data are included, and the function of feedback control is realized through a PID controller. The software realizes the functions of real-time data acquisition and laser irradiation power control.
In this example, OCT imaging technology is used to assist in reconstructing external and internal images of mouse skin, thereby helping to observe the extent of tissue damage in mouse skin.
Claims (10)
1. A photothermal therapy system based on temperature and image dual-mode monitoring and feedback can perform range-controllable accurate laser irradiation on tissues to be treated, and is characterized in that: the photothermal therapy system comprises a control feedback module (4), a photothermal therapy module (1) connected with the control feedback module, and a temperature monitoring module (2) capable of performing infrared imaging; the photothermal therapy module irradiates the tissue to be treated with laser to heat the tissue; the control feedback module acquires infrared thermal imaging of the tissue to be processed through the temperature monitoring module so as to evaluate whether a temperature rise range formed by current laser irradiation is within a preset threshold temperature range of the tissue to be processed and whether the temperature bearable by the tissue receiving laser irradiation meets a preset value.
2. The photothermal treatment system according to claim 1, wherein said system comprises: the photothermal therapy system further comprises an OCT image monitoring module (3) capable of three-dimensional imaging; the control feedback module acquires the image of the tissue to be processed through the OCT image monitoring module.
3. The photothermal treatment system according to claim 2, wherein said dual mode monitoring and feedback based on temperature and image is as follows: the control feedback module images the heated tissue to be processed through the OCT image monitoring module and reconstructs a three-dimensional image so as to acquire state change information of the surface and the interior of the tissue to be processed during irradiation and monitor whether the tissue to be processed is damaged by light and heat during irradiation.
4. The photothermal treatment system according to claim 1, wherein said system comprises: the temperature monitoring module comprises a thermal infrared imager (201); the photothermal treatment module comprises a first laser (101), a first collimator (102) and an optical fiber treatment head which are sequentially arranged on a laser light path of the photothermal treatment module; the laser of the first laser irradiates the tissue to be processed after passing through the first collimator and the optical fiber treatment head.
5. The photothermal treatment system according to claim 4, wherein said system comprises: when the optical fiber treatment head irradiates the tissue to be treated, the distance between the optical fiber treatment head and the tissue is 2 cm; the thermal infrared imager is fixed by an optical support, and the detection direction of the thermal infrared imager forms an oblique angle of 45 degrees with the irradiation part of the photothermal treatment module.
6. The photothermal treatment system according to claim 3, wherein said system comprises: the light source of the OCT image monitoring module is a second laser (301), and laser emitted by the second laser is emitted to the reference arm light path and the sample arm light path after passing through an isolator (302) and a fiber coupler (303); the laser entering the reference arm light path is emitted to a plane mirror (305) through a second collimator (304) in the reference arm light path, and then is reflected back to the optical fiber coupler by the plane mirror to form first return light; the laser entering the sample arm light path irradiates the tissue to be treated subjected to laser irradiation by the photothermal therapy module after passing through a third collimator (306), a reflecting mirror (307), a lens (308) and a scanning galvanometer (309) of the sample arm light path, and the reflected light forms second return light at the optical fiber coupler; the first return light and the second return light are output to a spectrometer (310) through coherent light formed at the optical fiber coupler; the control feedback module receives spectrometer data through a data acquisition card (311).
7. The photothermal treatment system according to claim 6, wherein said system comprises: the optical fiber coupler is a 2 x 2 coupler with a splitting ratio of 50: 50; the photothermal treatment system also comprises a numerical control sample table (5) for placing tissues to be treated; the numerical control sample stage is a three-axis electric precise electric control translation stage and can carry out three-dimensional adjustment on the position and the posture of the placed tissue to be processed.
8. The photothermal treatment system according to claim 7, wherein said system comprises: the control feedback module acquires optical data of the OCT image monitoring module through a data acquisition card, and acquires temperature detection data of the thermal infrared imager through the data acquisition card; the control feedback module controls the energy output of the first laser and the working states of the scanning galvanometer and the numerical control sample table according to the optical data and the temperature detection data, so that the temperature change caused by the irradiation of the laser to the tissue to be treated is kept within the set threshold range.
9. The system of claim 8, wherein the photothermal therapy system comprises: the control feedback module comprises a numerical control workstation, temperature data is processed by utilizing computer resources, the temperature of an irradiated tissue is kept within a threshold range by adjusting laser power, a three-dimensional image of the irradiated tissue is reconstructed by processing optical data of a data acquisition card through an Amira three-dimensional reconstruction algorithm, the damage range of photothermal therapy is divided, the functions of transmitting system data and controlling each instrument in the photothermal therapy system are realized through an RS-232 interface, and the control function of a LabVIEW compiling system is realized by using a virtual instrument technology, wherein the control function comprises the functions of realizing basic control function of laser, reading the temperature in real time, adjusting the laser power in real time and displaying the data in a visual mode, and realizing the function of feedback control through a PID controller.
10. The photothermal treatment system according to claim 4, wherein said system comprises: in order to prevent the radiance deviation caused by light reflection, thermal focusing and thermal diffusion effect when the laser irradiates the tissue from influencing the temperature measurement precision of the thermal infrared imager, the thermal infrared imager corrects the radiance deviation when the photothermal therapy system measures the temperature by correcting calibration operation,
the method for correcting the calibration operation comprises the following steps;
step S1, after the water surface is irradiated by laser with preset power for ten minutes, the irradiated area of the water surface is measured by a thermocouple, a thermometer and a thermal infrared imager respectively to obtain water temperature change data;
step S2, irradiating the isolated tissue similar to the tissue to be processed for ten minutes by using laser with preset power, and then measuring the temperature of the irradiated area of the isolated tissue by using a thermocouple and a thermal infrared imager respectively to obtain tissue temperature change data;
and S3, correcting and calibrating the thermal infrared imager according to the water temperature change data and the tissue temperature change data.
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