CN112516254B - Dendrobium officinale instant granules and preparation method thereof - Google Patents
Dendrobium officinale instant granules and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
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- 235000004879 dioscorea Nutrition 0.000 claims description 54
- 235000002722 Dioscorea batatas Nutrition 0.000 claims description 34
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims description 34
- 240000001811 Dioscorea oppositifolia Species 0.000 claims description 34
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims description 34
- 239000002002 slurry Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 18
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- 239000000203 mixture Substances 0.000 claims description 3
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- 230000007547 defect Effects 0.000 abstract description 2
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- 230000000052 comparative effect Effects 0.000 description 11
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- 229940079593 drug Drugs 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
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- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012353 t test Methods 0.000 description 3
- 241000026010 Dendrobium candidum Species 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the technical field of traditional Chinese medicine granule preparation, and particularly relates to dendrobium officinale instant granules and a preparation method thereof. The process for preparing the dendrobium officinale instant granules comprises the steps of crushing, size mixing, mixing and granulating; the crushing step is used for obtaining dendrobium officinale powder and yam powder; in the step of size mixing, the yam powder is dispersed in water and decocted, and yam powder pulp is obtained after cooling. Aiming at the defects of the prior art, the invention provides the instant dendrobium officinale granules and the processing and preparation method thereof, so that the requirements of people on convenient, natural and healthy health-care products are met, and the instant dendrobium officinale granules have a good market prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine granule preparation, and particularly relates to dendrobium officinale instant granules and a preparation method thereof.
Background
Dendrobe is a traditional rare Chinese medicinal material in China, and is widely distributed in Yunnan, Guizhou, Sichuan and other places. Dendrobe has many health care effects such as anti-oxidation, hypoglycemic, anti-tumor, improvement organism immunity, so widely used in medicine, health food. In recent years, dendrobium officinale, dendrobium candidum and the like are listed as dual-purpose varieties for medicine and food, and the development of diversified foods and medicines by using dendrobium candidum has become a hot spot in the industry.
Dendrobium officinale is already listed as a medicine and food dual-purpose variety, and development of diversified foods and medicines by Dendrobium officinale is a hot spot in the industry. The traditional product form of the dendrobium officinale is that the dendrobium officinale is in a shape of a maple pipe or a slice, and the dendrobium officinale is not convenient to take in a decocting mode, a soaking mode and the like, and is not suitable for the simple and convenient requirements of the modern society on medicines and foods at a fast pace. The dendrobium officinale powder is a mainstream product form due to good sanitary and safety control, convenient carrying and more convenient use. However, the dendrobium officinale powder still has obvious defects in administration: the dendrobium officinale is rich in polysaccharide, the powder has strong hygroscopicity, and the powder is very easy to adhere to teeth and palate after being directly taken, so that the dendrobium officinale is difficult to swallow; when the powder is taken with water, the powder is often agglomerated and is difficult to disperse, and the taking is inconvenient.
Disclosure of Invention
The invention aims to provide dendrobium officinale instant granules to solve the technical problem that dendrobium officinale food or medicine is inconvenient to take in the prior art.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of instant herba Dendrobii granule comprises pulverizing, mixing, and granulating; the crushing step is used for obtaining dendrobium officinale powder and yam powder; in the step of size mixing, the yam powder is dispersed in water and decocted, and yam powder pulp is obtained after cooling.
The principle and the advantages of the scheme are as follows: the dendrobium officinale has certain nutrition and health care effects on the stomach and intestine, and the best application form is to take the dendrobium officinale in the form of decoction. However, because the dendrobium officinale is rich in polysaccharide and pectin, the dendrobium officinale granules (medicinal granules) are viscous in material property, strong in hygroscopicity, easy to agglomerate and difficult to disperse, and are a technical pain point of market products, and most products are added with chemical diluents, disintegrants and cosolvents. Aiming at the key problem, the invention adopts yam which is a medicine-food dual-purpose variety as a diluent, and utilizes the characteristic of high content of sticky substances such as polysaccharide and the like of the dendrobium officinale to take the effect of the dendrobium officinale as a binder, thereby preparing the dendrobium officinale instant granules. In the preparation process, the yam powder is gelatinized in boiling water to obtain yam powder slurry, which can be used for assisting in particle forming and dispersion in water. The dendrobium officinale instant granules prepared by the scheme can be rapidly dissolved and dispersed in cold water and hot water, the formula does not contain any chemical additive, the most key technical obstacle in the application of the dendrobium officinale is solved, the requirements of modern society on natural, healthy and zero-additive safe health-care products are met, and the product has good market economic expectation.
Further, in the step of mixing the slurry, the yam powder is dispersed in water and decocted for 15min, and then cooled to room temperature to obtain yam powder slurry.
By adopting the technical scheme, orthogonal tests prove that the dendrobium officinale instant granules obtained by dispersing the yam powder in water and decocting for 15min have shorter dispersion time.
Further, the mass ratio of the yam powder to the water is 1: 2.5.
By adopting the technical scheme, the mass ratio can ensure that the yam powder is fully swelled and dispersed in water to form homogenized yam powder slurry.
Further, in the crushing step, the dendrobium officinale raw material and the Chinese yam raw material are respectively crushed and then respectively sieved by a 120-mesh sieve to obtain dendrobium officinale powder and Chinese yam powder; the mass ratio of the Chinese yam powder used in the size mixing step to the Chinese yam powder used in the mixing step is 1:2.
By adopting the technical scheme and through orthogonal test verification, the instant granules prepared from the dendrobium officinale powder and the yam powder with the granularity have shorter dispersion time. In addition, the yam flour is used in the size mixing step and the mixing step. In the mixing step, the dendrobium officinale powder is wrapped by the dried yam powder, and then the dried yam powder is mixed with the yam powder slurry, so that the granulation is facilitated in the granulating process. In the subsequent process of dispersing in water, the interface between the yam powder and the dendrobium officinale powder is loosely combined, so that the process of dissolving the instant granules in water is accelerated.
Further, the dendrobium officinale raw material is dendrobium officinale dry strips, dendrobium officinale slices or dendrobium officinale bailer.
By adopting the technical scheme, the dendrobium officinale dry strips, slices or maple leaves are common decoction piece forms of dendrobium officinale medicinal materials, and can be used for further processing of dendrobium officinale tablets.
Further, in the mixing step, 7 parts by mass of dendrobium officinale powder and 2 parts by mass of Chinese yam powder are mixed, then 1 part by mass of Chinese yam powder prepared into Chinese yam powder slurry is added, and the mixture is uniformly mixed to obtain a soft granular material.
By adopting the technical scheme, the yam powder wraps the dendrobium officinale powder with high viscosity, and the mixture of the yam powder slurry wraps the yam powder, so that the particles in the granulating step are easier to form. When the formed instant granules are dissolved in water, the interface between the yam powder and the dendrobium officinale powder is loosely combined, and the dissolution of the instant granules is accelerated.
Further, in the granulation step, the soft particle material is treated to obtain the dendrobium officinale instant particles with the particle size of 20 meshes.
By adopting the technical scheme, orthogonal tests prove that the dendrobium officinale granules with the grain size of 20 meshes are dispersed in water quickly, and the dispersion performance of the granules can be improved.
Further, the dendrobium officinale instant granules prepared by the preparation method of the dendrobium officinale instant granules.
By adopting the technical scheme, the dendrobium officinale instant granules prepared by the method consist of dendrobium officinale and Chinese yam, have simple process, are convenient to take and carry, and have good market prospect.
Further, the dendrobium officinale instant granules comprise 7 parts by mass of dendrobium officinale powder and 3 parts by mass of yam powder.
By adopting the technical scheme, the dendrobium officinale instant granules with good forming effect and good dispersion effect can be prepared by adopting the dendrobium officinale powder and the yam powder in the proportion.
Further, the yam powder is used for preparing yam powder slurry; the Chinese yam powder slurry is prepared by the following method: dispersing rhizoma Dioscoreae powder in water, decocting for 15min, and cooling to room temperature to obtain rhizoma Dioscoreae powder slurry.
By adopting the technical scheme, in the preparation process, the yam powder is pasted in boiling water to obtain yam powder slurry, which can be helpful for particle forming and dispersion in water.
Detailed Description
The following is further detailed by way of specific embodiments:
example 1:
the dendrobium officinale instant granules are prepared from dendrobium officinale and Chinese yam by crushing, mixing, granulating and drying the raw materials, and specifically comprise the following steps:
(1) pulverizing
Taking the dendrobium officinale raw material, crushing, and sieving with a 120-mesh sieve to obtain the dendrobium officinale powder. The embodiment specifically selects the dry strip of dendrobium officinale as the raw material of dendrobium officinale, and the dry strip, the slice or the maple funnel of dendrobium officinale can be selected during actual use, which are common decoction piece forms of dendrobium officinale medicinal materials. Pulverizing rhizoma Dioscoreae raw material (rhizoma Dioscoreae decoction pieces), and sieving with 120 mesh sieve to obtain rhizoma Dioscoreae powder.
(2) Size mixing
Taking 1 part of rhizoma Dioscoreae powder, adding 2.5 times of water (1kg of rhizoma Dioscoreae powder corresponds to 2.5kg of water), boiling for 15min (decocting for 15min), and standing at room temperature to obtain rhizoma Dioscoreae powder slurry.
(3) Mixing
And (3) taking 7 parts of dendrobium officinale powder and 2 parts of yam powder, uniformly mixing, adding the yam powder slurry obtained in the step (2), stirring while adding, uniformly mixing, and preparing into a soft granular material.
(4) Granulating
Taking the soft granules, granulating by a swing type granulator (using a 20-mesh screen), drying, and grading to obtain the instant dendrobium officinale granules.
The particle dispersibility is used as an index (determined according to a suspended particle dispersibility inspection method in Chinese pharmacopoeia (four parts) granule (0104)), and the granularity of the dendrobium officinale and the Chinese yam, the proportion of the dendrobium officinale and the Chinese yam and the preparation of Chinese yam powder slurry are optimized and screened by four factors and three levels. After the particles are prepared, carrying out a dispersion test by using water at 75 ℃, examining by using dispersion time as an index, and failing to test when the dispersion time exceeds 5 min; the score was 100X (1-T/5), i.e., the score was higher as the dispersion time was shorter (T is melting time). The factor level table is detailed in table 1, the orthogonal test results are detailed in table 2, and the anova results are detailed in table 3. Wherein, in table 1, the mass ratio of the yam powder used in the size mixing step to the yam powder used in the mixing step is 1:2.
Table 1: factor level meter
Table 2: l is9(34) Orthogonal experiment table
Table 3: analysis of variance table
Note: f0.05(2，2)＝19.00
By combining the above conditions, the optimal inclusion process is determined as A2B2C3D1Namely, the granularity of the dendrobium officinale and the Chinese yam is 120 meshes, the proportion of the dendrobium officinale to the Chinese yam is 7:3, the Chinese yam powder is decocted by 2.5 times of water for 15min, and the granularity of the dendrobium officinale instant granules is 20 meshes.
Example 2
This example is a specific scale-up run based on the experimental results of example 1. Taking 100kg of dendrobium officinale and 30kg of Chinese yam, respectively crushing, and sieving with a 120-mesh sieve to obtain dendrobium officinale powder and Chinese yam powder. Taking 10kg of the yam powder, adding 25kg of water, heating and boiling for 15min, standing and cooling to room temperature to obtain yam powder slurry; taking 70kg of dendrobium officinale powder and 20kg of Chinese yam powder, uniformly mixing, adding the Chinese yam powder slurry while stirring, and uniformly mixing; granulating with a 20-mesh screen by a swing granulator, drying at 80 ℃, and finishing granules to obtain 108.5 kg of instant dendrobium officinale granules (electuary).
Experimental example 1
Dispersibility test (n is 3) is performed on the instant dendrobium officinale granules prepared in example 2, and the results are shown in table 4.
Table 4: dispersibility test results (n ═ 3)
The results of the experimental example 1 show that the instant granules obtained by the invention can be well dispersed in normal temperature and hot water, have no agglomeration phenomenon, short time, good dissolution state and convenient administration.
Comparative example 1
Selecting a medicinal and edible dual-purpose variety with low sugar content and little pectin as a diluent and a dispersant (used for replacing the Chinese yam in example 2) of the dendrobium officinale instant granules, preparing the dendrobium officinale instant granules by adopting the preparation method in example 2, evaluating the color, the flavor, the taste, the dispersibility and the like of the granules, and obtaining screening results detailed in table 5. The measurement is carried out according to the examination method of the dispersibility of the suspension granules in the item of Chinese pharmacopoeia (four parts) granules (0104). 5g of the dendrobium officinale instant granules are dissolved in 80ml of water at 45 ℃, water is added, stirring is carried out, and the time for the granules to be completely dissolved (dispersing time) is recorded.
Table 5: food material replacement experiment result (n ═ 3)
The tests show that the buckwheat, the konjak and the oat are poor in dispersibility and the lily is good in dispersibility under the condition of adding the same amount of diluted materials, but the lily is strong in flavor, so that the natural flavor of the dendrobium is affected, the yam is light in nature and has no peculiar smell, the prepared particles are good in dispersibility, and the flavor and the taste of the dendrobium officinale are not affected, so that the dendrobium officinale instant particles select the yam as the dispersing agent and the diluting agent. The yam is used as a dispersant and a diluent of the dendrobium officinale instant granules, and the dispersion time of the yam-containing granules is obviously shorter than that of other food materials (buckwheat, konjak, oat and lily) containing granules (the yam group, the buckwheat group, the konjak group, the oat group and the lily group are respectively subjected to t-test in pairs, and P is less than 0.05, so that the difference is obvious).
Comparative example 2
The comparative example is basically the same as example 2, but different from the application and dosage of the raw materials such as yam, and the like, and the comparative example is as follows:
1.5kg of dendrobium officinale and 0.3kg of Chinese yam are taken, respectively crushed and sieved by a 120-mesh sieve to obtain dendrobium officinale powder and Chinese yam powder. Adding 0.1kg of rhizoma Dioscoreae powder into 0.25kg of water, boiling for 15min, standing, and cooling to room temperature to obtain rhizoma Dioscoreae powder slurry; taking 0.7kg of dendrobium officinale powder, adding all the yam powder slurry, stirring while adding, and uniformly mixing; granulating with 20 mesh sieve by swing granulator, drying at 80 deg.C, and grading to obtain instant granule of herba Dendrobii. The obtained instant dendrobium officinale granules are subjected to a dispersibility test (see comparative example 1 in the experimental process), and the average dispersion time of the granules is 3.73(n is 3). The experimental results (dispersion time) of this comparative example were compared with the data of number 2 of Table 4, and they were significantly different (t-test, P < 0.05). This illustrates the importance of using yam flour in two steps (size mixing step and mixing step). In the mixing step, the dendrobium officinale powder is wrapped by the dried yam powder, and then the dried yam powder is mixed with the yam powder slurry, so that the granulation is facilitated in the granulating process. In the subsequent process of dispersing in water, the interface between the yam powder and the dendrobium officinale powder is loosely combined, so that the process of dissolving the instant granules in water is accelerated.
The inventor also tries a scheme of directly mixing and granulating the yam powder and the dendrobium officinale powder, but the yam powder slurry is lacked, so that the particles are difficult to form in the granulating process.
Comparative example 3
The comparative example is basically the same as example 2, but different from the application and the dosage of the raw materials such as yam and the like, and the comparative example is as follows:
taking 2.0kg of dendrobium officinale and 0.2kg of Chinese yam, respectively crushing, and sieving with a 120-mesh sieve to obtain dendrobium officinale powder and Chinese yam powder. Taking 0.1kg of dendrobium officinale powder, adding into 0.25kg of water, heating and boiling for 15min, standing and cooling to room temperature to obtain dendrobium powder slurry; taking 0.7kg of dendrobium officinale powder and 0.2kg of Chinese yam powder, mixing uniformly, adding the Chinese yam powder slurry while stirring, and mixing uniformly; granulating with 20 mesh sieve by swing granulator, drying at 80 deg.C, and grading to obtain instant granule of herba Dendrobii. The obtained instant dendrobium officinale granules are subjected to a dispersibility test (see comparative example 1 in the experimental process), and the average dispersion time of the granules is 3.60min (n is 3). The experimental results (dispersion time) of this comparative example were compared with the data of number 2 of table 4, and they were significantly different (t-test, P < 0.05). The instant granules prepared by using the dendrobium officinale powder as dendrobium powder slurry have poor instant effect.
The foregoing is merely an example of the present invention and common general knowledge in the art of designing and/or characterizing particular aspects and/or features is not described in any greater detail herein. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several variations and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (6)
1. A preparation method of dendrobium officinale instant granules is characterized by comprising the steps of crushing, size mixing, mixing and granulating; in the crushing step, the dendrobium officinale raw material and the Chinese yam raw material are respectively crushed and then respectively sieved by a 120-mesh sieve to obtain dendrobium officinale powder and Chinese yam powder; the mass ratio of the Chinese yam powder used in the size mixing step to the Chinese yam powder used in the mixing step is 1: 2;
in the step of size mixing, 1 part by mass of yam powder is dispersed in water and decocted, and yam powder pulp is obtained after cooling;
in the mixing step, 7 parts by mass of dendrobium officinale powder and 2 parts by mass of Chinese yam powder are mixed, then 1 part by mass of Chinese yam powder prepared Chinese yam powder slurry is added, and the mixture is uniformly mixed to obtain a soft granular material.
2. The method of claim 1, wherein in the step of mixing, the yam powder is dispersed in water and decocted for 15min, and then cooled to room temperature to obtain yam powder slurry.
3. The preparation method of dendrobium officinale instant granules according to claim 2, wherein the mass ratio of the yam powder to the water is 1: 2.5.
4. The method for preparing dendrobium officinale instant granules according to claim 3, wherein the dendrobium officinale raw material is dendrobium officinale dry strips, dendrobium officinale slices or dendrobium officinale kimura et migo.
5. The method for preparing dendrobium officinale instant granules according to claim 4, wherein in the granulating step, a 20-mesh screen is used for granulating the soft granules.
6. The dendrobium officinale instant granules prepared by the preparation method of the dendrobium officinale instant granules according to any one of claims 1-5.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907670A (en) * | 2012-10-22 | 2013-02-06 | 广西壮族自治区农业科学院农产品加工研究所 | Compound dendrobium candidum and American ginseng buccal tablets and preparation method thereof |
| CN104069366A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Stock dendrobium officinale preparation and preparation method thereof |
| CN104958567A (en) * | 2015-08-04 | 2015-10-07 | 桂林伯林生物技术有限公司 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
| CN105535546A (en) * | 2016-01-21 | 2016-05-04 | 南京师范大学 | Dendrobium nobile micro powder composition containing cyclodextrin and preparation method and preparation thereof |
| CN107019761A (en) * | 2016-01-29 | 2017-08-08 | 林东昊 | A kind of instant stem of noble dendrobium fine grained and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102380043B (en) * | 2011-11-17 | 2013-03-06 | 云南金九地生物科技有限公司 | Method for processing dendrobium candidum ultrafine powder |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102907670A (en) * | 2012-10-22 | 2013-02-06 | 广西壮族自治区农业科学院农产品加工研究所 | Compound dendrobium candidum and American ginseng buccal tablets and preparation method thereof |
| CN104069366A (en) * | 2014-06-23 | 2014-10-01 | 广西圣保堂药业有限公司 | Stock dendrobium officinale preparation and preparation method thereof |
| CN104958567A (en) * | 2015-08-04 | 2015-10-07 | 桂林伯林生物技术有限公司 | Dendrobium candidum wall.ex lindl lozenge and preparation method thereof |
| CN105535546A (en) * | 2016-01-21 | 2016-05-04 | 南京师范大学 | Dendrobium nobile micro powder composition containing cyclodextrin and preparation method and preparation thereof |
| CN107019761A (en) * | 2016-01-29 | 2017-08-08 | 林东昊 | A kind of instant stem of noble dendrobium fine grained and preparation method thereof |
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