CN112469734A - 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 - Google Patents
表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 Download PDFInfo
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
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Abstract
本发明提供了一种表达嵌合抗原受体的T细胞，所述嵌合抗原受体包括胞外结构域，所述胞外结构域识别靶细胞表面上的靶抗原，从而介导所述T细胞对所述靶细胞的杀伤；所述T细胞自身也表达所述靶抗原，并且为了防止所述T细胞相互杀伤，所述T细胞对所述靶抗原的表达被下调。本发明还提供了包含所述嵌合抗原受体编码序列的表达载体。本发明提供的T细胞可通过靶向CS1抗原而用于对CS1阳性细胞的非正常增殖引起的疾病的治疗，同时由于下调了所述T细胞的CS1表达而防止了所述T细胞相互杀伤，有利于所述T细胞在体外和体内扩增和存活。
Description
PCT国内申请，说明书已公开。
Claims (31)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810880137 | 2018-08-03 | ||
| CN2018108801379 | 2018-08-03 | ||
| PCT/CN2019/099000 WO2020025039A1 (zh) | 2018-08-03 | 2019-08-02 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
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| Publication Number | Publication Date |
|---|---|
| CN112469734A true CN112469734A (zh) | 2021-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201980049205.XA Pending CN112469734A (zh) | 2018-08-03 | 2019-08-02 | 表达嵌合抗原受体的t细胞、该嵌合抗原相关表达载体以及它们的应用 |
Country Status (2)
| Country | Link |
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| CN (1) | CN112469734A (zh) |
| WO (1) | WO2020025039A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023116782A1 (zh) * | 2021-12-21 | 2023-06-29 | 上海驯鹿生物技术有限公司 | 靶向gprc5d的全人源抗体和嵌合抗原受体(car)及其应用 |
| CN116410331A (zh) * | 2021-12-31 | 2023-07-11 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104829730A (zh) * | 2015-04-14 | 2015-08-12 | 苏静 | 一种能联合免疫细胞增强肿瘤杀伤能力的双特异性抗体及其制备方法和应用 |
| CN105906720A (zh) * | 2016-05-16 | 2016-08-31 | 武汉汉密顿生物科技股份有限公司 | 靶向性嵌合抗原受体修饰的免疫细胞及其制备方法和应用 |
| CN107429253A (zh) * | 2014-12-05 | 2017-12-01 | 希望之城公司 | Cs1靶向性嵌合抗原受体修饰的t细胞 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX370173B (es) * | 2013-05-03 | 2019-12-04 | Ohio State Innovation Foundation | Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1. |
-
2019
- 2019-08-02 WO PCT/CN2019/099000 patent/WO2020025039A1/zh active Application Filing
- 2019-08-02 CN CN201980049205.XA patent/CN112469734A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107429253A (zh) * | 2014-12-05 | 2017-12-01 | 希望之城公司 | Cs1靶向性嵌合抗原受体修饰的t细胞 |
| CN104829730A (zh) * | 2015-04-14 | 2015-08-12 | 苏静 | 一种能联合免疫细胞增强肿瘤杀伤能力的双特异性抗体及其制备方法和应用 |
| CN105906720A (zh) * | 2016-05-16 | 2016-08-31 | 武汉汉密顿生物科技股份有限公司 | 靶向性嵌合抗原受体修饰的免疫细胞及其制备方法和应用 |
Non-Patent Citations (2)
| Title |
|---|
| ROMAN GALETTO等: "Bypassing the Constraint for Chimeric Antigen Receptor (CAR) Development in T-Cells Expressing the Targeted Antigen: Improvement of Anti-CS1 CAR Activity in Allogenic TCRa/CS1 Double Knockout T-Cells for the Treatment of Multiple Myeloma (MM)", 《BLOOD》 * |
| YU-TZU TAI等: "Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu", 《BLOOD》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023116782A1 (zh) * | 2021-12-21 | 2023-06-29 | 上海驯鹿生物技术有限公司 | 靶向gprc5d的全人源抗体和嵌合抗原受体(car)及其应用 |
| CN116410331A (zh) * | 2021-12-31 | 2023-07-11 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
| CN116410331B (zh) * | 2021-12-31 | 2024-01-30 | 合源生物科技(天津)有限公司 | 靶向cs1的嵌合抗原受体、靶向bcma/cs1的双特异性嵌合抗原受体及其应用 |
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| WO2020025039A1 (zh) | 2020-02-06 |
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