CN112370566A - Preparation process of bionic material hemostatic gauze - Google Patents

Preparation process of bionic material hemostatic gauze Download PDF

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CN112370566A
CN112370566A CN202011332589.7A CN202011332589A CN112370566A CN 112370566 A CN112370566 A CN 112370566A CN 202011332589 A CN202011332589 A CN 202011332589A CN 112370566 A CN112370566 A CN 112370566A
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parts
water
gauze
preparing
hemostatic gauze
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陈剑璋
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Medwell Medical Products Co ltd
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Medwell Medical Products Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104Silver, e.g. silver sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

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Abstract

The invention belongs to the technical field of hemostatic gauze production, and particularly discloses a preparation process of a bionic material hemostatic gauze, which provides the following scheme and comprises the following steps: preparing the following raw materials in parts by weight: 30-40 parts of water-absorbent resin, 25-35 parts of fiber, 20-30 parts of a moisture absorbent, 20-30 parts of a hydrophilic agent, 12-22 parts of polyvinyl alcohol, 8-17 parts of hydroxyethyl cellulose, 55-220 parts of water, 12-34 parts of halloysite, 8-22 parts of calomel, 6-24 parts of red lead, 7-19 parts of gypsum rubrum, 5-24 parts of dried alum, 4-14 parts of rheum officinale and 11-37 parts of bighead atractylodes rhizome. The gauze has the advantages of astringency, eliminating dampness, drawing out toxin, removing putrefaction, strong anti-infection capability, good hemostatic property, good wound healing effect, good scar lightening property, rapid healing of floating tissues, improvement of the use quality of the gauze, smoothness, comfort, moisture absorption, air permeability and more comfort.

Description

Preparation process of bionic material hemostatic gauze
Technical Field
The invention relates to the technical field of hemostatic gauze production, in particular to a preparation process of a bionic material hemostatic gauze.
Background
The medical gauze is mainly used for bandaging wounds and cleaning blood stains of the wounds in the operation process. Generally, the finished medical gauze product leaving the factory has two supply modes, one is a non-sterile mode, and the other is a sterile mode. The aseptically packaged medical gauze can be directly used, and the non-aseptically packaged gauze can be used after being sterilized by high-temperature high-pressure steam or ethylene oxide and the like. The base material of the medical gauze piece is medical absorbent gauze, and the gauze piece is soft, odorless and tasteless; the gauze pieces should be folded flat without burrs, stubble exposed outside and loose thread ends; the medical gauze pieces can be divided into folded edges, unfolded edges, flat shapes, napped edges, cut edges, with and without developing lines, and can also be divided into sterilized gauze pieces and non-sterilized gauze pieces from the aspect of packaging.
When the existing hemostatic gauze is used, the hemostatic effect is general, and scars are easy to leave on wound after wrapping, so that the invention provides a preparation process of the bionic material hemostatic gauze.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a preparation process of a bionic material hemostatic gauze.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation process of bionic material hemostatic gauze comprises the following steps:
s1, preparing the following raw materials in parts by weight: 30-40 parts of water-absorbing resin, 25-35 parts of fiber, 20-30 parts of moisture absorbent, 20-30 parts of hydrophilic agent, 12-22 parts of polyvinyl alcohol, 8-17 parts of hydroxyethyl cellulose, 55-220 parts of water, 12-34 parts of halloysite, 8-22 parts of calomel, 6-24 parts of red lead, 7-19 parts of gypsum rubrum, 5-24 parts of dried alum and 4-14 parts of rhubarb, 11-37 parts of bighead atractylodes rhizome, 9-24 parts of carbonized sanguisorba root, 6-24 parts of pseudo-ginseng, 15-23 parts of cimicifuga foetida, 17-34 parts of liquorice, 10-20 parts of geranium, 3-8 parts of rhizoma typhonii, 5-10 parts of cortex dictamni, 10-20 parts of amomum cardamomum, 5-15 parts of bletilla striata, 10-15 parts of burdock, 22-98 parts of carboxymethyl, 55-128 parts of soluble silver salt and 330 parts of water 150-;
s2, dissolving water-absorbing resin, fiber, moisture absorbent, hydrophilic agent, polyvinyl alcohol and hydroxyethyl cellulose in water, stirring and swelling at 10-24 ℃, heating to 75-85 ℃, and stirring for 2h to obtain solution A;
s3, preparation of a hemostatic agent: grinding Halloysitum rubrum, Calomelas, Plumbum Preparatium, Mirabilitum crystallina, dried Alumen, radix et rhizoma Rhei, Atractylodis rhizoma, charred radix Sangusorbae, Notoginseng radix, cimicifugae rhizoma and Glycyrrhrizae radix, mixing, decocting in water for 4-8 hr at 80-99 deg.C, and filtering to obtain filtrate A;
s4, preparing a scar lightening agent: pulverizing flos Pelargonii Hortori, rhizoma Typhonii, cortex Dictamni Radicis, fructus Amomi rotundus, rhizoma Bletillae and Burdock, stirring, mixing, decocting, and filtering to obtain filtrate B;
and S5, adding the filtrate B into the filtrate A, stirring for 50-90min, dropwise adding the solution A into the mixed solution of the filtrate A and the filtrate B while stirring, then carrying out ultrasonic oscillation to obtain a spinning solution, carrying out puffing pretreatment on the spinning solution, carrying out carboxymethylation modification treatment, adding soluble silver salt, reacting at a constant temperature of 28-55 ℃ for 1h, finally passivating, rinsing with clear water, dehydrating and drying to obtain the degradable hemostatic gauze.
Preferably, in the step S1, the following raw materials in parts by weight are prepared: 60-70 parts of water, 37-38 parts of glycerol, 0.02-0.04 part of sodium chloride, 0.13-0.17 part of methylparaben, 0.45-0.55 part of polyaminopropyl biguanide, 1.5-2.5 parts of magnolia flower extract, 1.5-2.5 parts of peony root bark extract, 6.5-7.5 parts of cinnamon extract, 6.5-7.5 parts of scutellaria baicalensis extract, 6.5-7.5 parts of butanediol, 0.015-0.025 part of caramel, 60-70 parts of mineral oil, 36-38 parts of ethylhexyl palmitate, 3.5-4.5 parts of bisabolol and 3.5-4.5 parts of vitamin E.
Preferably, in the step S1, the following raw materials in parts by weight are prepared: 65 parts of water, 37 parts of glycerol, 0.03 part of sodium chloride, 0.15 part of methylparaben, 0.5 part of polyaminopropyl biguanide, 2 parts of magnolia flower extract, 2 parts of peony root bark extract, 7 parts of cinnamon extract, 7 parts of scutellaria baicalensis extract, 7 parts of butanediol, 0.02 part of caramel color, 65 parts of mineral oil, 37 parts of ethylhexyl palmitate, 4 parts of bisabolol and 4 parts of vitamin E.
Preferably, in the step S3, water, glycerin, sodium chloride and methyl hydroxybenzoate are added into an aqueous phase pot and heated to 85 ℃, and after heat preservation and stirring are carried out for 20 minutes, the temperature is reduced.
Preferably, in S4, when the temperature is reduced to 45 ℃, the mixture is added with polyaminopropyl biguanide, magnolia extract, peony root bark extract, cinnamon extract, scutellaria extract, butylene glycol and caramel color, stirred and dispersed uniformly, and the discharged material is water aqua.
Preferably, in S6, the water agent and the oil agent are filtered by the fine filter screen into the plastic barrel covered with the plastic bag, and then sealed, and then placed in a standing room for 12 hours, and then the semi-finished product is inspected, and after the semi-finished product is qualified, the water agent and the oil agent are mixed according to the ratio of 3: 2, uniformly mixing the components in proportion, filling the mixture into a sterilized packaging bag, performing appearance inspection, reserving a sample for a finished product QC, performing inspection on the finished product, and finally warehousing and storing.
Compared with the prior art, the invention has the beneficial effects that:
the red halloysite, the calomel, the minium, the gypsum rubrum, the dried alum, the rhubarb, the white atractylodes rhizome, the carbonized sanguisorba root, the pseudo-ginseng, the rhizoma cimicifugae and the liquorice which have the effects of promoting tissue regeneration and promoting granulation have the advantages of astringency and eliminating dampness, toxin drawing and removing, strong anti-infection capability, good hemostatic performance and good wound healing effect.
The gauze has good scar fading performance, helps floating tissues to heal quickly, and improves the use quality of the gauze by combining the gauze with a solution prepared by decocting geranium, rhizoma typhonii, cortex dictamni, amomum cardamomum, bletilla striata and burdock.
The gauze is prepared from the water-absorbent resin, the fibers, the moisture absorbent, the hydrophilic agent, the polyvinyl alcohol and the hydroxyethyl cellulose, so that the prepared gauze has smooth hand feeling, is soft and comfortable, absorbs moisture and is breathable, has better comfort and can accelerate the blood coagulation process.
The gauze has the advantages of astringency, eliminating dampness, drawing out toxin, removing putrefaction, strong anti-infection capability, good hemostatic property, good wound healing effect, good scar lightening property, rapid healing of floating tissues, improvement of the use quality of the gauze, smoothness, comfort, moisture absorption, air permeability and more comfort.
Drawings
FIG. 1 is a process flow diagram of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example one
The invention provides a preparation process of bionic material hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 30 parts of water-absorbent resin, 25 parts of fiber, 20 parts of a moisture absorbent, 20 parts of a hydrophilic agent, 12 parts of polyvinyl alcohol, 8 parts of hydroxyethyl cellulose, 55 parts of water, 12 parts of halloysite, 8 parts of calomel, 6 parts of minium, 7 parts of calcite, 5 parts of dried alum, 4 parts of rheum officinale, 11 parts of bighead atractylodes rhizome, 9 parts of garden burnet root charcoal, 6 parts of pseudo-ginseng, 15 parts of cimicifuga foetida, 17 parts of liquorice, 10 parts of geranium, 3 parts of rhizoma typhonii, 5 parts of cortex dictamni, 10 parts of amomum cardamomum, 5 parts of bletilla striata, 10 parts of burdock, 22 parts of carboxymethyl, 55 parts of soluble silver salt and 150 parts of water;
s2, dissolving water-absorbing resin, fibers, a moisture absorbent, a hydrophilic agent, polyvinyl alcohol and hydroxyethyl cellulose in water, stirring and swelling at 10 ℃, heating to 75 ℃, and stirring for 2 hours to obtain a solution A;
s3, preparation of a hemostatic agent: grinding Halloysitum rubrum, Calomelas, Plumbum Preparatium, Mirabilitum crystallina, dried Alumen, radix et rhizoma Rhei, Atractylodis rhizoma, charred radix Sangusorbae, Notoginseng radix, cimicifugae rhizoma and Glycyrrhrizae radix, mixing, decocting with water for 4 hr at 80 deg.C, and filtering to obtain filtrate A;
s4, preparing a scar lightening agent: pulverizing flos Pelargonii Hortori, rhizoma Typhonii, cortex Dictamni Radicis, fructus Amomi rotundus, rhizoma Bletillae and Burdock, stirring, mixing, decocting, and filtering to obtain filtrate B;
and S5, adding the filtrate B into the filtrate A, stirring for 50min, dropwise adding the solution A into the mixed solution of the filtrate A and the filtrate B while stirring, then ultrasonically oscillating to obtain a spinning solution, puffing the spinning solution for pretreatment, performing carboxymethylation modification treatment, adding soluble silver salt, reacting at the constant temperature of 28 ℃ for 1h, finally passivating, rinsing with clear water, dehydrating and drying to obtain the degradable hemostatic gauze.
Example two
The invention provides a preparation process of bionic material hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 35 parts of water-absorbent resin, 30 parts of fiber, 25 parts of moisture absorbent, 25 parts of hydrophilic agent, 18 parts of polyvinyl alcohol, 14 parts of hydroxyethyl cellulose, 150 parts of water, 22 parts of halloysite, 16 parts of calomel, 15 parts of minium, 14 parts of calcite, 17 parts of dried alum, 11 parts of rheum officinale, 22 parts of bighead atractylodes rhizome, 17 parts of garden burnet root charcoal, 15 parts of pseudo-ginseng, 19 parts of cimicifugae foetidae, 25 parts of liquorice, 15 parts of geranium, 5 parts of rhizoma typhonii, 7 parts of cortex dictamni, 15 parts of amomum cardamomum, 10 parts of bletilla striata, 12 parts of burdock, 65 parts of carboxymethyl, 88 parts of soluble silver salt and 240 parts of water;
s2, dissolving water-absorbing resin, fiber, a moisture absorbent, a hydrophilic agent, polyvinyl alcohol and hydroxyethyl cellulose in water, stirring and swelling at 18 ℃, heating to 80 ℃, and stirring for 2 hours to obtain a solution A;
s3, preparation of a hemostatic agent: grinding Halloysitum rubrum, Calomelas, Plumbum Preparatium, Mirabilitum crystallina, dried Alumen, radix et rhizoma Rhei, Atractylodis rhizoma, charred radix Sangusorbae, Notoginseng radix, cimicifugae rhizoma and Glycyrrhrizae radix, mixing, decocting with water for 6 hr at 90 deg.C, and filtering to obtain filtrate A;
s4, preparing a scar lightening agent: pulverizing flos Pelargonii Hortori, rhizoma Typhonii, cortex Dictamni Radicis, fructus Amomi rotundus, rhizoma Bletillae and Burdock, stirring, mixing, decocting, and filtering to obtain filtrate B;
and S5, adding the filtrate B into the filtrate A, stirring for 70min, dropwise adding the solution A into the mixed solution of the filtrate A and the filtrate B while stirring, then ultrasonically oscillating to obtain a spinning solution, puffing the spinning solution for pretreatment, performing carboxymethylation modification treatment, adding soluble silver salt, reacting at the constant temperature of 43 ℃ for 1h, finally passivating, rinsing with clear water, dehydrating and drying to obtain the degradable hemostatic gauze.
EXAMPLE III
The invention provides a preparation process of bionic material hemostatic gauze, which comprises the following steps:
s1, preparing the following raw materials in parts by weight: 40 parts of water-absorbent resin, 35 parts of fiber, 30 parts of a moisture absorbent, 30 parts of a hydrophilic agent, 22 parts of polyvinyl alcohol, 17 parts of hydroxyethyl cellulose, 220 parts of water, 34 parts of halloysite, 22 parts of calomel, 24 parts of minium, 19 parts of calcite, 24 parts of dried alum, 14 parts of rheum officinale, 37 parts of bighead atractylodes rhizome, 24 parts of garden burnet root charcoal, 24 parts of pseudo-ginseng, 23 parts of cimicifuga foetida, 34 parts of liquorice, 20 parts of geranium, 8 parts of rhizoma typhonii, 10 parts of cortex dictamni, 20 parts of amomum cardamomum, 15 parts of bletilla striata, 15 parts of burdock, 98 parts of carboxymethyl, 128 parts of soluble silver salt and 330 parts of water;
s2, dissolving water-absorbing resin, fiber, a moisture absorbent, a hydrophilic agent, polyvinyl alcohol and hydroxyethyl cellulose in water, stirring and swelling at 24 ℃, heating to 85 ℃, and stirring for 2 hours to obtain a solution A;
s3, preparation of a hemostatic agent: grinding Halloysitum rubrum, Calomelas, Plumbum Preparatium, Mirabilitum crystallina, dried Alumen, radix et rhizoma Rhei, Atractylodis rhizoma, charred radix Sangusorbae, Notoginseng radix, cimicifugae rhizoma and Glycyrrhrizae radix, mixing, decocting with water for 8 hr at 99 deg.C, and filtering to obtain filtrate A;
s4, preparing a scar lightening agent: pulverizing flos Pelargonii Hortori, rhizoma Typhonii, cortex Dictamni Radicis, fructus Amomi rotundus, rhizoma Bletillae and Burdock, stirring, mixing, decocting, and filtering to obtain filtrate B;
and S5, adding the filtrate B into the filtrate A, stirring for 50-90min, dropwise adding the solution A into the mixed solution of the filtrate A and the filtrate B while stirring, then carrying out ultrasonic oscillation to obtain a spinning solution, carrying out puffing pretreatment on the spinning solution, carrying out carboxymethylation modification treatment, adding soluble silver salt, reacting at the constant temperature of 55 ℃ for 1h, finally passivating, rinsing with clear water, dehydrating and drying to obtain the degradable hemostatic gauze.
The invention has strong astringency and eliminating dampness, toxin drawing and decay removing, anti-infection capability, good hemostatic performance and good wound healing efficacy through the red halloysite, the calomel, the red lead, the gypsum rubrum, the dried alum, the rhubarb, the white atractylodes rhizome, the carbonized sanguisorba root, the pseudo-ginseng, the cimicifuga foetida and the liquorice which have the efficacies of promoting tissue regeneration and promoting granulation. The gauze has good scar fading performance, helps floating tissues to heal quickly, and improves the use quality of the gauze by combining the gauze with a solution prepared by decocting geranium, rhizoma typhonii, cortex dictamni, amomum cardamomum, bletilla striata and burdock. The gauze is prepared from the water-absorbent resin, the fibers, the moisture absorbent, the hydrophilic agent, the polyvinyl alcohol and the hydroxyethyl cellulose, so that the prepared gauze has smooth hand feeling, is soft and comfortable, absorbs moisture and is breathable, has better comfort and can accelerate the blood coagulation process.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (7)

1. A preparation process of bionic material hemostatic gauze is characterized by comprising the following steps:
s1, preparing the following raw materials in parts by weight: 30-40 parts of water-absorbing resin, 25-35 parts of fiber, 20-30 parts of moisture absorbent, 20-30 parts of hydrophilic agent, 12-22 parts of polyvinyl alcohol, 8-17 parts of hydroxyethyl cellulose, 55-220 parts of water, 12-34 parts of halloysite, 8-22 parts of calomel, 6-24 parts of red lead, 7-19 parts of gypsum rubrum, 5-24 parts of dried alum and 4-14 parts of rhubarb, 11-37 parts of bighead atractylodes rhizome, 9-24 parts of carbonized sanguisorba root, 6-24 parts of pseudo-ginseng, 15-23 parts of cimicifuga foetida, 17-34 parts of liquorice, 10-20 parts of geranium, 3-8 parts of rhizoma typhonii, 5-10 parts of cortex dictamni, 10-20 parts of amomum cardamomum, 5-15 parts of bletilla striata, 10-15 parts of burdock, 22-98 parts of carboxymethyl, 55-128 parts of soluble silver salt and 330 parts of water 150-;
s2, dissolving water-absorbing resin, fiber, moisture absorbent, hydrophilic agent, polyvinyl alcohol and hydroxyethyl cellulose in water, stirring and swelling at 10-24 ℃, heating to 75-85 ℃, and stirring for 2h to obtain solution A;
s3, preparation of a hemostatic agent: grinding Halloysitum rubrum, Calomelas, Plumbum Preparatium, Mirabilitum crystallina, dried Alumen, radix et rhizoma Rhei, Atractylodis rhizoma, charred radix Sangusorbae, Notoginseng radix, cimicifugae rhizoma and Glycyrrhrizae radix, mixing, decocting in water for 4-8 hr at 80-99 deg.C, and filtering to obtain filtrate A;
s4, preparing a scar lightening agent: pulverizing flos Pelargonii Hortori, rhizoma Typhonii, cortex Dictamni Radicis, fructus Amomi rotundus, rhizoma Bletillae and Burdock, stirring, mixing, decocting, and filtering to obtain filtrate B;
and S5, adding the filtrate B into the filtrate A, stirring for 50-90min, dropwise adding the solution A into the mixed solution of the filtrate A and the filtrate B while stirring, then carrying out ultrasonic oscillation to obtain a spinning solution, carrying out puffing pretreatment on the spinning solution, carrying out carboxymethylation modification treatment, adding soluble silver salt, reacting at a constant temperature of 28-55 ℃ for 1h, finally passivating, rinsing with clear water, dehydrating and drying to obtain the degradable hemostatic gauze.
2. The process for preparing biomimetic material hemostatic gauze according to claim 1, wherein in the step S1, the following raw materials in parts by weight are prepared: 30-35 parts of water-absorbing resin, 25-33 parts of fiber, 20-25 parts of moisture absorbent, 20-28 parts of hydrophilic agent, 12-19 parts of polyvinyl alcohol, 8-16 parts of hydroxyethyl cellulose, 55-180 parts of water, 12-32 parts of halloysite, 8-21 parts of calomel, 6-18 parts of red lead, 7-17 parts of gypsum rubrum, 5-21 parts of dried alum and 4-12 parts of rhubarb, 11-28 parts of bighead atractylodes rhizome, 9-21 parts of carbonized sanguisorba root, 6-19 parts of pseudo-ginseng, 15-20 parts of cimicifuga foetida, 17-27 parts of liquorice, 10-18 parts of geranium, 3-7 parts of rhizoma typhonii, 5-9 parts of cortex dictamni, 10-18 parts of amomum cardamomum, 5-13 parts of bletilla striata, 10-14 parts of burdock, 22-78 parts of carboxymethyl, 55-112 parts of soluble silver salt and 280 parts of water 150-.
3. The process for preparing biomimetic material hemostatic gauze according to claim 1, wherein in the step S1, the following raw materials in parts by weight are prepared: 32-40 parts of water-absorbing resin, 27-35 parts of fiber, 23-30 parts of moisture absorbent, 24-30 parts of hydrophilic agent, 15-22 parts of polyvinyl alcohol, 12-17 parts of hydroxyethyl cellulose, 77-220 parts of water, 21-34 parts of halloysite, 13-22 parts of calomel, 15-24 parts of red lead, 12-19 parts of gypsum rubrum, 13-24 parts of dried alum and 7-14 parts of rhubarb, 18-37 parts of bighead atractylodes rhizome, 14-24 parts of carbonized sanguisorba root, 13-24 parts of pseudo-ginseng, 18-23 parts of cimicifuga foetida, 20-34 parts of liquorice, 13-20 parts of geranium, 4-8 parts of rhizoma typhonii, 6-10 parts of cortex dictamni, 12-20 parts of amomum cardamomum, 8-15 parts of bletilla striata, 12-15 parts of burdock, 34-98 parts of carboxymethyl, 75-128 parts of soluble silver salt and 330 parts of water 180-.
4. The process for preparing biomimetic material hemostatic gauze according to claim 1, wherein in the step S1, the following raw materials in parts by weight are prepared: 35 parts of water-absorbent resin, 30 parts of fiber, 25 parts of moisture absorbent, 25 parts of hydrophilic agent, 18 parts of polyvinyl alcohol, 14 parts of hydroxyethyl cellulose, 150 parts of water, 22 parts of halloysite, 16 parts of calomel, 15 parts of minium, 14 parts of calcite, 17 parts of dried alum, 11 parts of rheum officinale, 22 parts of bighead atractylodes rhizome, 17 parts of garden burnet root charcoal, 15 parts of pseudo-ginseng, 19 parts of cimicifugae foetidae, 25 parts of liquorice, 15 parts of geranium, 5 parts of rhizoma typhonii, 7 parts of cortex dictamni, 15 parts of amomum cardamomum, 10 parts of bletilla striata, 12 parts of burdock, 65 parts of carboxymethyl, 88 parts of soluble silver salt and 240 parts of water.
5. The process for preparing hemostatic gauze as claimed in claim 1, wherein in S1, the hydrophilic agent is any one of benzalkonium chloride, benzalkonium chloride and cetrimide, and the water absorbent agent is any one of aluminum oxide and calcium chloride.
6. The process for preparing hemostatic gauze of biomimetic material according to claim 1, wherein in S5, drying is performed for 6 hours in a vacuum drying oven at 85-120 ℃.
7. The process for preparing hemostatic gauze as claimed in claim 1, wherein the step S2 is performed by mixing with a blender at a speed of 350r/min for 1-2 h.
CN202011332589.7A 2020-11-24 2020-11-24 Preparation process of bionic material hemostatic gauze Pending CN112370566A (en)

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040096487A1 (en) * 1999-11-17 2004-05-20 Sg Licensing Corporation Method and composition for the treatment of scars
CN104436287A (en) * 2014-12-17 2015-03-25 安徽省健源医疗器械设备有限公司 Polyvinyl alcohol hemostatic gauze and preparation method thereof
CN104524624A (en) * 2014-12-17 2015-04-22 安徽省健源医疗器械设备有限公司 Chitosan hemostatic gauze and preparation method thereof
CN105671942A (en) * 2016-01-07 2016-06-15 江苏天章医用卫生新材料有限公司 Method for preparing medical antibacterial cotton gauze
CN105887331A (en) * 2015-01-26 2016-08-24 重庆联佰博超医疗器械有限公司 Preparation method for hydroxyethyl cellulose hemostatic gauze
CN107254732A (en) * 2017-05-31 2017-10-17 太仓东能环保设备有限公司 A kind of high water absorption medical absorbent cotton gauze and preparation method thereof
CN108330681A (en) * 2017-12-25 2018-07-27 江苏天章医用卫生新材料股份有限公司 A kind of medical cotton gauze preparation process and method
CN108360248A (en) * 2017-12-25 2018-08-03 江苏天章医用卫生新材料股份有限公司 A kind of preparation method for the cotton gauze that medical use water absorbing capacity is strong
CN109252356A (en) * 2018-08-13 2019-01-22 四川美迪康医疗器械有限公司 A kind of fiber gauze production technology of high intensity
CN109260499A (en) * 2018-09-13 2019-01-25 广州润虹医药科技股份有限公司 A kind of degradable hemostatic gauze and preparation method thereof
CN110791950A (en) * 2019-11-14 2020-02-14 成工业制衣(苏州)有限公司 Method for preparing soluble hemostatic textile material

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040096487A1 (en) * 1999-11-17 2004-05-20 Sg Licensing Corporation Method and composition for the treatment of scars
CN104436287A (en) * 2014-12-17 2015-03-25 安徽省健源医疗器械设备有限公司 Polyvinyl alcohol hemostatic gauze and preparation method thereof
CN104524624A (en) * 2014-12-17 2015-04-22 安徽省健源医疗器械设备有限公司 Chitosan hemostatic gauze and preparation method thereof
CN105887331A (en) * 2015-01-26 2016-08-24 重庆联佰博超医疗器械有限公司 Preparation method for hydroxyethyl cellulose hemostatic gauze
CN105671942A (en) * 2016-01-07 2016-06-15 江苏天章医用卫生新材料有限公司 Method for preparing medical antibacterial cotton gauze
CN107254732A (en) * 2017-05-31 2017-10-17 太仓东能环保设备有限公司 A kind of high water absorption medical absorbent cotton gauze and preparation method thereof
CN108330681A (en) * 2017-12-25 2018-07-27 江苏天章医用卫生新材料股份有限公司 A kind of medical cotton gauze preparation process and method
CN108360248A (en) * 2017-12-25 2018-08-03 江苏天章医用卫生新材料股份有限公司 A kind of preparation method for the cotton gauze that medical use water absorbing capacity is strong
CN109252356A (en) * 2018-08-13 2019-01-22 四川美迪康医疗器械有限公司 A kind of fiber gauze production technology of high intensity
CN109260499A (en) * 2018-09-13 2019-01-25 广州润虹医药科技股份有限公司 A kind of degradable hemostatic gauze and preparation method thereof
CN110791950A (en) * 2019-11-14 2020-02-14 成工业制衣(苏州)有限公司 Method for preparing soluble hemostatic textile material

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
董放,程云章主编: "《无源医疗器械产品与不良事件监测》", 30 September 2013, 中国医药科技出版社 *

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