CN104474579A - Hydroxypropyl-beta-cyclodextrin hemostatic gauze and preparation method thereof - Google Patents
Hydroxypropyl-beta-cyclodextrin hemostatic gauze and preparation method thereof Download PDFInfo
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- CN104474579A CN104474579A CN201410780439.0A CN201410780439A CN104474579A CN 104474579 A CN104474579 A CN 104474579A CN 201410780439 A CN201410780439 A CN 201410780439A CN 104474579 A CN104474579 A CN 104474579A
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Abstract
The invention discloses hydroxypropyl-beta-cyclodextrin hemostatic gauze. The hydroxypropyl-beta-cyclodextrin hemostatic gauze is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of luffa leaves, 1-2 parts of cacumen biotae, 1-2 parts of sangusis draconis, 1-2 parts of mock strawberry, 0.5-1 part of pine pollen, 6-8 parts of hydroxypropyl-beta-cyclodextrin, 6-8 parts of gelatin, 3-5 parts of sodium alginate, 0.1-0.2 part of polysorbate-80, 0.5-1 part of caprylic capric triglyceride, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of auxiliary materials, and 200-250 parts of water. The soluble hemostatic gauze disclosed by the invention is collaboratively prepared from natural high polymer materials of hydroxypropyl-beta-cyclodextrin and the like, is fast in hemostatic effect, is capable of effectively promoting wound healing, is good in antibacterial effect, is easily absorbed by human body, is good in biocompatibility, and is free from toxic or side effects; the soluble hemostatic gauze is capable of resisting bacteria in a broad spectrum, and diminishing inflammation and easing pain by extracting and compounding natural plant effective ingredients, has a controlled-release function, effectively prolongs the action time, and achieves a better use effect.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of HP-β-CD hemostatic gauze and preparation method thereof.
Background technology
Along with the continuous progress of medical skill, new medical material and correlation technique obtain good development.Wherein the development of hemostatic material and improvement be conducive to improving perform the operation out, the problem of oozing of blood, have great importance, become the focus of current field of medicaments research.Traditional hemostatic gauze is generally made up of Cotton Gossypii, linen etc., have that antibacterial bacteriostatic ability, scrim fiber easily cause foreign material repulsion to react affect wound healing, easy and wound tissue adhesion when using, cause the problems such as secondary damage, and the waste treatment processes produced after using is complicated, easy contaminated environment.
Soluble stanching gauze is the good novel hemostatic material of one of development in recent years, has stronger affinity, absorb moisture and dissolve after running into blood water and saline, blocking blood capillary end and reach the object of hemostasis.Soluble stanching gauze also has good histocompatibility, frivolous softness, is convenient to carry out the operations such as coated filling, has high using value and the market demand potential.
Summary of the invention
The object of this invention is to provide a kind of HP-β-CD hemostatic gauze, this hemostatic gauze has good water solublity and biocompatibility, is easily absorbed by the body, and has no side effect, anti-inflammation, and haemostatic effect is good.
The present invention is achieved by the following technical solutions:
A kind of HP-β-CD hemostatic gauze, it is characterized in that, it is obtained by the raw material of following weight parts:
Folium Luffae 3-5, Cacumen Platycladi 1-2, Sanguis Draxonis 1-2, Herba Duchesneae Indicae 1-2, Pollen Pini 0.5-1, HP-β-CD 6-8, gelatin 6-8, sodium alginate 3-5, Tween-80 0.1-0.2, decanoyl/octanoyl glycerides 0.5-1, sodium carboxymethyl cellulose 2-4, adjuvant 1-2, water 200-250;
Wherein adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
A preparation method for HP-β-CD hemostatic gauze, is characterized in that, comprises the following steps:
(1) by solvent and solute weight ratio 10:1-8:1 Folium Luffae, Cacumen Platycladi, Sanguis Draxonis, Herba Duchesneae Indicae and Pollen Pini added in the acetum of 4-8% and decoct 4-8h, filter, be concentrated into the 1/10-1/8 of original volume after pH being adjusted to neutrality, obtain concentrated solution; Described concentrated solution and gelatin, HP-β-CD and Tween-80 are added jointly in the water that 1/3-1/2 measures, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, stir 1-2h under adding decanoyl/octanoyl glycerides and adjuvant 40-50 DEG C, equally rotating speed again, after cooling, obtain component A;
(2) add in the water of surplus by sodium alginate and sodium carboxymethyl cellulose, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
Folium Luffae is cucurbitaceous plant Fructus Luffae or Guangdong Fructus Luffae blade, and primary efficacy has hemostasis, heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing; Sanguis Draxonis medical material Ji Yuan takes from the resin in babassu Sanguis Draxonis fruit and rattan, has effect of removing blood stasis and relieving pain, hemostasia and promoting granulation, also has the pharmacological action of bactericidal antiphlogistic.
Advantage of the present invention is:
The present invention obtains soluble stanching gauze by natural macromolecular material synergism synthesis composite fibres such as HP-β-CD, gelatin, sodium alginate, sodium carboxymethyl cellulose, anthemorrhagic speed is fast, effective promotion wound healing, good anti-bacterial effect, be easily absorbed by the body, good biocompatibility, has no side effect; By extracting and composite active ingredient of natural plant, energy broad-spectrum antiseptic, anti-inflammatory analgesic, and there is slow releasing function, effectively extend action time, reach better result of use.
Detailed description of the invention
Non-limiting examples of the present invention is as follows:
A kind of HP-β-CD hemostatic gauze, is prepared from by the component raw material of following weight (kg):
Folium Luffae 4, Cacumen Platycladi 1.5, Sanguis Draxonis 1.5, Herba Duchesneae Indicae 1.5, Pollen Pini 0.8, HP-β-CD 7, gelatin 7, sodium alginate 4, Tween-80 0.15, decanoyl/octanoyl glycerides 0.8, sodium carboxymethyl cellulose 3, adjuvant 1.5, water 200;
Wherein, adjuvant is made up of the raw material of following weight (kg):
Soybean lecithin 0.8, glycerol 3, Polyethylene Glycol 1.5, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1.5, mannitol 3, chlorhexidine gluconate 1.5, vitamin C 1.5, water 18;
The preparation method of adjuvant:
Soybean lecithin is added to the water 60 DEG C, 1000r/min stirs 1h, then add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition and stir 15min, add all the other raw materials 600r/min after cooling and stir 5min, to obtain final product.
The preparation method of HP-β-CD hemostatic gauze comprises the following steps:
(1) by solvent and solute weight ratio 10:1 Folium Luffae, Cacumen Platycladi, Sanguis Draxonis, Herba Duchesneae Indicae and Pollen Pini added in the acetum of 6% and decoct 6h, filter, be concentrated into 1/10 of original volume after pH being adjusted to neutrality, obtain concentrated solution; Described concentrated solution and gelatin, HP-β-CD and Tween-80 are added in the water of 1/2 amount jointly, prior to 80 DEG C, 600r/min stirs 0.5-1h, stir 1h under adding decanoyl/octanoyl glycerides and adjuvant 50 DEG C, equally rotating speed again, after cooling, obtain component A;
(2) add in the water of surplus by sodium alginate and sodium carboxymethyl cellulose, 1000r/min stirs 0.5h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 2% citric acid (mass ratio) and 70% ethanol (volume ratio), coagulation bath temperature is 30 DEG C, and spinning speed is 4m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
The hemostatic gauze obtained to the present embodiment is verified:
Haemostatic effect: mice docking experiment, mice docking bleeding time <15s;
Absorbability: mice subcutaneous absorption is tested, can absorb in 3 weeks, reaction without exception completely.
Claims (2)
1. a HP-β-CD hemostatic gauze, is characterized in that, it is obtained by the raw material of following weight parts:
Folium Luffae 3-5, Cacumen Platycladi 1-2, Sanguis Draxonis 1-2, Herba Duchesneae Indicae 1-2, Pollen Pini 0.5-1, HP-β-CD 6-8, gelatin 6-8, sodium alginate 3-5, Tween-80 0.1-0.2, decanoyl/octanoyl glycerides 0.5-1, sodium carboxymethyl cellulose 2-4, adjuvant 1-2, water 200-250;
Described adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of described adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
2. the preparation method of a kind of HP-β-CD hemostatic gauze according to claim 1, is characterized in that, comprise the following steps:
(1) by solvent and solute weight ratio 10:1-8:1 Folium Luffae, Cacumen Platycladi, Sanguis Draxonis, Herba Duchesneae Indicae and Pollen Pini added in the acetum of 4-8% and decoct 4-8h, filter, be concentrated into the 1/10-1/8 of original volume after pH being adjusted to neutrality, obtain concentrated solution; Described concentrated solution and gelatin, HP-β-CD and Tween-80 are added jointly in the water that 1/3-1/2 measures, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, stir 1-2h under adding decanoyl/octanoyl glycerides and adjuvant 40-50 DEG C, equally rotating speed again, after cooling, obtain component A;
(2) add in the water of surplus by sodium alginate and sodium carboxymethyl cellulose, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108498844A (en) * | 2017-12-18 | 2018-09-07 | 张祖玲 | A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof |
CN110042488A (en) * | 2019-04-23 | 2019-07-23 | 武汉大学 | A kind of preparation method of inexpensive, green, efficient high strength fibre element silk |
US20200330203A1 (en) * | 2019-04-17 | 2020-10-22 | Norman F. Dahl, III | Hemostatic paste with light-curable feature |
CN113073469A (en) * | 2021-03-10 | 2021-07-06 | 浙江大学 | Preparation method of medical antibacterial gauze |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091302A (en) * | 1993-07-24 | 1994-08-31 | 郝忠全 | The processing method of carbon haemostatic powder |
CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
CN101524545A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Hemostatic gel suppository |
CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
CN103239753A (en) * | 2013-04-28 | 2013-08-14 | 华南理工大学 | Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof |
CN103316377A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Beta-cyclodextrin/carboxymethyl chitosan medical dressing and preparation method thereof |
CN103611185A (en) * | 2013-12-03 | 2014-03-05 | 安徽缘远博爱生物技术有限公司 | Antiseptic radix sophorae flavescentis soluble hemostatic gauze |
CN103623458A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Pseudo-ginsheng blood circulation and healing promoting water-soluble hemostatic gauze |
-
2014
- 2014-12-17 CN CN201410780439.0A patent/CN104474579A/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1091302A (en) * | 1993-07-24 | 1994-08-31 | 郝忠全 | The processing method of carbon haemostatic powder |
CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
CN101524545A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Hemostatic gel suppository |
CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
CN103239753A (en) * | 2013-04-28 | 2013-08-14 | 华南理工大学 | Hydroxypropyl-beta-cyclodextrin/chitosan medical dressing and preparation method thereof |
CN103316377A (en) * | 2013-06-27 | 2013-09-25 | 华南理工大学 | Beta-cyclodextrin/carboxymethyl chitosan medical dressing and preparation method thereof |
CN103611185A (en) * | 2013-12-03 | 2014-03-05 | 安徽缘远博爱生物技术有限公司 | Antiseptic radix sophorae flavescentis soluble hemostatic gauze |
CN103623458A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Pseudo-ginsheng blood circulation and healing promoting water-soluble hemostatic gauze |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108498844A (en) * | 2017-12-18 | 2018-09-07 | 张祖玲 | A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof |
US20200330203A1 (en) * | 2019-04-17 | 2020-10-22 | Norman F. Dahl, III | Hemostatic paste with light-curable feature |
CN110042488A (en) * | 2019-04-23 | 2019-07-23 | 武汉大学 | A kind of preparation method of inexpensive, green, efficient high strength fibre element silk |
CN110042488B (en) * | 2019-04-23 | 2020-07-24 | 武汉大学 | Low-cost, green and efficient preparation method of high-strength cellulose filaments |
CN113073469A (en) * | 2021-03-10 | 2021-07-06 | 浙江大学 | Preparation method of medical antibacterial gauze |
CN113073469B (en) * | 2021-03-10 | 2021-12-28 | 浙江大学 | Preparation method of medical antibacterial gauze |
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