CN112321957A - High-cleanness rubber plug - Google Patents
High-cleanness rubber plug Download PDFInfo
- Publication number
- CN112321957A CN112321957A CN202011198355.8A CN202011198355A CN112321957A CN 112321957 A CN112321957 A CN 112321957A CN 202011198355 A CN202011198355 A CN 202011198355A CN 112321957 A CN112321957 A CN 112321957A
- Authority
- CN
- China
- Prior art keywords
- rubber plug
- exxpro3433
- plug according
- high cleanliness
- rubber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001971 elastomer Polymers 0.000 title claims abstract description 41
- 239000000806 elastomer Substances 0.000 claims abstract description 18
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 11
- 229920005989 resin Polymers 0.000 claims abstract description 11
- -1 alkyl phenyl-phenol disulfide Chemical compound 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 239000011787 zinc oxide Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 239000011159 matrix material Substances 0.000 claims abstract description 3
- 230000003749 cleanliness Effects 0.000 claims description 12
- 238000000465 moulding Methods 0.000 claims description 7
- 239000000049 pigment Substances 0.000 claims description 6
- 239000005995 Aluminium silicate Substances 0.000 claims description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 235000012211 aluminium silicate Nutrition 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000006229 carbon black Substances 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 239000003973 paint Substances 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 238000004073 vulcanization Methods 0.000 abstract description 15
- 229920005549 butyl rubber Polymers 0.000 abstract description 9
- 239000000284 extract Substances 0.000 abstract description 9
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract description 5
- 229910052717 sulfur Inorganic materials 0.000 abstract description 5
- 239000011593 sulfur Substances 0.000 abstract description 5
- 238000002386 leaching Methods 0.000 abstract description 4
- 239000011521 glass Substances 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 22
- 229940079593 drug Drugs 0.000 description 10
- 238000000034 method Methods 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 description 3
- 241001411320 Eriogonum inflatum Species 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical group BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 2
- 230000031709 bromination Effects 0.000 description 2
- 238000005893 bromination reaction Methods 0.000 description 2
- 238000010382 chemical cross-linking Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012632 extractable Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000003801 milling Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 239000004636 vulcanized rubber Substances 0.000 description 2
- 229930186147 Cephalosporin Natural products 0.000 description 1
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical group CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011011 extractables test Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
Landscapes
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention relates to a matched product of a medicinal glass product, in particular to a high-cleanness rubber plug which is prepared by taking an EXXPRO3433 special elastomer as a matrix rubber and alkyl phenyl-phenol disulfide resin J-PV7 as a vulcanizing agent through mixing, vulcanizing and forming. The invention has the following advantages: (1) the use of an alkyl-phenyl-phenol disulfide resin J-PV7 as a vulcanizing agent for EXXPRO3433 specialty elastomers; (2) the proper vulcanization speed is achieved by adjusting the dosage of the alkyl phenyl-phenol disulfide resin J-PV7 and zinc oxide, and simultaneously, the leaching of lower free sulfur and zinc ions in the formula is ensured. (3) Compared with the butyl rubber plug existing in the current market, the formula product has lower extracts and extractives.
Description
Technical Field
The invention relates to a matched product of a medicinal glass product, in particular to a high-cleanness rubber plug.
Background
The medicine is a special commodity directly related to human health and safety, and besides the inherent performance of the medicine, the packaging of the medicine, particularly the packaging material directly contacting the medicine, plays a decisive role in the medicine. The butyl rubber plug is used as a packaging material which is in direct contact with the medicine, and the inherent cleanliness of the butyl rubber plug has great influence on the medicine. The butyl rubber plug has a complex formula, uses more raw materials, is absorbed, adsorbed, leached and permeated by medicines after being packaged with the medicines with stronger molecular activity, generates the compatibility problem of the rubber plug and the medicines, and is more prominent to part of cephalosporins, part of large infusion solutions, more traditional Chinese medicine injection preparations and the like.
Therefore, the proper material is selected to manufacture the butyl rubber bottle stopper with higher internal cleanliness, so that the possibility of absorption, adsorption, leaching and permeation of the medicine is reduced, and the method becomes a development trend of the butyl rubber bottle stopper.
The commonly used butyl rubber bottle stopper at present is easy to interact when contacting with medicines, so that the risk of polluting the medicines exists; when the rubber plug is in long-term contact with the medicine, small molecular substances in the rubber plug migrate into the medicine, so that the medicine quality and potential safety hazards are caused; and has poor compatibility with medicines, thus easily causing the failure and the deterioration of the medicines.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the high-cleanness rubber plug which has good compatibility with medicines, can ensure the stability of the medicines, can greatly reduce extracts and extractables and does not pollute the medicines in long-term storage.
The high-cleanness rubber plug is prepared by taking an EXXPRO3433 special elastomer as a matrix rubber and taking alkyl phenyl-phenol disulfide resin J-PV7 as a vulcanizing agent through mixing, vulcanizing and forming.
Wherein the EXXPRO3433 special elastomer is a special elastomer with the mark of 3433 produced by Exxon Mobil chemical company in the United states, and belongs to the field of butyl rubber. The Exxpro specialty elastomer is a brominated polymer made from isobutylene and para-methylstyrene (PMS) copolymer. The copolymer has wide monomer ratio and molecular weight selection range, and products with different bromination degrees can be obtained by brominating the copolymer, so that Exxpro special elastomers with different brands can be obtained. Wherein Exxpro3433 is brominated-p-methylstyrene. Bromination selectively occurs on the methyl group of PMS, providing active benzyl bromide functionality, which is also critical for vulcanization and various modifications of Exxpro specialty elastomers. The unique performance comes from a fully saturated polyisobutene framework and a high-activity benzyl bromide functional group.
The alkylphenyl disulfide resin J-PV7 was manufactured by Nippon Kabushiki Kaisha.
Furthermore, the mass of the alkyl phenyl-phenol disulfide resin J-PV7 is 1-3% of that of the EXXPRO3433 special elastomer.
Furthermore, the zinc oxide powder also comprises an active agent, wherein the active agent is zinc oxide. The mass of the zinc oxide is 3-5% of that of the EXXPRO3433 special elastomer.
Still further, the composite material also comprises a filler, wherein the filler is calcined kaolin. The mass of the calcined kaolin is 60-80% of that of the EXXPRO3433 special elastomer.
Furthermore, the paint also comprises a pigment, wherein the pigment is one or two of titanium dioxide or carbon black. The mass of the pigment is 2.1-3.3% of that of the EXXPRO3433 special elastomer.
The high-cleanness rubber plug is prepared by the conventional mixing and vulcanization molding process without special limitation. The method specifically comprises the following steps:
(1) mixing: after the raw materials are qualified, the raw materials are mixed according to the formula, and then banburying and open milling are carried out to mix various raw materials.
(2) Preforming: the rubber compound is extruded, rolled, cooled and cut into pieces for storage.
(3) And (3) vulcanization molding: according to the specified process, chemical crosslinking and vulcanization molding are carried out in vulcanization equipment.
(4) Removing edges: and punching the vulcanized rubber sheet to form a single product.
(5) Cleaning: the product is cleaned, and the product cleanliness is improved.
In summary, the invention has the following advantages:
(1) the use of an alkyl-phenyl-phenol disulfide resin J-PV7 as a vulcanizing agent for EXXPRO3433 specialty elastomers;
(2) variable verification is carried out by adjusting the dosage of the alkyl phenyl-phenol disulfide resin J-PV7 and zinc oxide, the optimal proportion of the two is determined according to the inspection data of the actual extraction of free sulfur and zinc ions, so that the proper vulcanization speed is achieved, the two can fully react, less unreacted substances in the product are ensured, and the leaching of lower free sulfur and zinc ions in the formula is ensured.
(3) Compared with the butyl rubber plug existing in the current market, the formula product has lower extracts and extractives.
Detailed Description
The present invention will be further described with reference to the following examples.
Example 1:
the preparation process is not particularly limited, and the conventional mixing and vulcanization molding processes are adopted. The method specifically comprises the following steps:
(1) mixing: after the raw materials are qualified, the raw materials are mixed according to the formula, and then banburying and open milling are carried out to mix various raw materials.
(2) Preforming: the rubber compound is extruded, rolled, cooled and cut into pieces for storage.
(3) And (3) vulcanization molding: according to the specified process, chemical crosslinking and vulcanization molding are carried out in vulcanization equipment.
(4) Removing edges: and punching the vulcanized rubber sheet to form a single product.
(5) Cleaning: the product is cleaned, and the product cleanliness is improved.
Example 2:
the preparation process is the same as in example 1.
Example 3:
the preparation process is the same as in example 1.
Example 4:
the preparation process is the same as in example 1.
Comparative example 1:
the preparation process is the same as in example 1.
Test example:
the quick test was performed for examples 1 to 4.
Vulcanization conditions are as follows: 193 ℃ for 6 min.
Through comparison of quick test data of examples 1 to 4, the highest torque values of examples 2, 3 and 4 accord with an expected adjustment direction, the vulcanization speed and the vulcanization degree of the examples meet production requirements, but the content of extractable free sulfur and zinc ions is verified according to an extract experiment in actual selection, and the optimal proportion is determined.
Extract data:
through analysis of extract detection data, the data of examples 2 and 3 are expected, but the content of zinc ions in example 3 is higher than that in example 2, so that the best choice is selected from example 2, and the fact that the alkyl phenyl phenol disulfide resin J-PV7 and zinc oxide can achieve a proper vulcanization speed and simultaneously ensure low leaching of free sulfur and zinc ions in the formula can be proved.
A partial extractables test was performed for example 2 and comparative example 1, and the data are shown in the following table:
note: ND means not detected
Through the partial extract detection data of comparative example 2 and comparative example 1, the cleanliness of example 2 is obviously better than that of comparative example 1, so that the fact that the extract and the extract are low can be proved.
Claims (8)
1. A high clean plug is characterized in that: the rubber is prepared by taking EXXPRO3433 special elastomer as matrix rubber and alkyl phenyl-phenol disulfide resin J-PV7 as a vulcanizing agent through mixing, vulcanizing and molding.
2. The high cleanliness rubber plug according to claim 1, wherein: the mass of the alkyl phenyl-phenol disulfide resin J-PV7 is 1-3% of that of the EXXPRO3433 special elastomer.
3. The high cleanliness rubber plug according to claim 1, wherein: the zinc oxide powder also comprises an active agent, wherein the active agent is zinc oxide.
4. The high cleanliness rubber plug according to claim 3, wherein: the mass of the zinc oxide is 3-5% of that of the EXXPRO3433 special elastomer.
5. The high cleanliness rubber plug according to claim 1, wherein: the composite material also comprises a filler, wherein the filler is calcined kaolin.
6. The high cleanliness rubber plug according to claim 5, wherein: the mass of the calcined kaolin is 60-80% of that of the EXXPRO3433 special elastomer.
7. The high cleanliness rubber plug according to claim 1, wherein: the paint also comprises a pigment, wherein the pigment is one or two of titanium dioxide or carbon black.
8. The high cleanliness rubber plug according to claim 7, wherein: the mass of the pigment is 2.1-3.3% of that of the EXXPRO3433 special elastomer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011198355.8A CN112321957A (en) | 2020-10-31 | 2020-10-31 | High-cleanness rubber plug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011198355.8A CN112321957A (en) | 2020-10-31 | 2020-10-31 | High-cleanness rubber plug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112321957A true CN112321957A (en) | 2021-02-05 |
Family
ID=74323959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011198355.8A Pending CN112321957A (en) | 2020-10-31 | 2020-10-31 | High-cleanness rubber plug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112321957A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116003924A (en) * | 2022-12-21 | 2023-04-25 | 山东省药用玻璃股份有限公司 | Preparation formula and preparation process of pre-filled and sealed piston |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2589214A1 (en) * | 2004-12-29 | 2006-07-06 | Exxonmobil Chemical Patents Inc. | Processable filled, curable halogenated isoolefin elastomers |
| CN101909882A (en) * | 2007-11-14 | 2010-12-08 | 陶氏环球技术公司 | Articles and methods of making the same |
| CN101991501A (en) * | 2009-08-27 | 2011-03-30 | 郑州市翱翔医药包装有限公司 | Ultraclean medicinal bottle plug and manufacturing method thereof |
| CN110776699A (en) * | 2019-10-28 | 2020-02-11 | 郑州大学 | Radiation-resistant sterilizing medicinal thermoplastic elastomer and preparation method thereof |
| CN111019254A (en) * | 2019-12-23 | 2020-04-17 | 山东省药用玻璃股份有限公司 | Brominated butyl rubber plug for alkali-resistant medicine and preparation method thereof |
-
2020
- 2020-10-31 CN CN202011198355.8A patent/CN112321957A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2589214A1 (en) * | 2004-12-29 | 2006-07-06 | Exxonmobil Chemical Patents Inc. | Processable filled, curable halogenated isoolefin elastomers |
| CN101909882A (en) * | 2007-11-14 | 2010-12-08 | 陶氏环球技术公司 | Articles and methods of making the same |
| CN101991501A (en) * | 2009-08-27 | 2011-03-30 | 郑州市翱翔医药包装有限公司 | Ultraclean medicinal bottle plug and manufacturing method thereof |
| CN110776699A (en) * | 2019-10-28 | 2020-02-11 | 郑州大学 | Radiation-resistant sterilizing medicinal thermoplastic elastomer and preparation method thereof |
| CN111019254A (en) * | 2019-12-23 | 2020-04-17 | 山东省药用玻璃股份有限公司 | Brominated butyl rubber plug for alkali-resistant medicine and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116003924A (en) * | 2022-12-21 | 2023-04-25 | 山东省药用玻璃股份有限公司 | Preparation formula and preparation process of pre-filled and sealed piston |
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|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210205 |