CN107163420A - A kind of Medical medicine bottle port rubber plug material and preparation method thereof - Google Patents
A kind of Medical medicine bottle port rubber plug material and preparation method thereof Download PDFInfo
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- CN107163420A CN107163420A CN201710397871.5A CN201710397871A CN107163420A CN 107163420 A CN107163420 A CN 107163420A CN 201710397871 A CN201710397871 A CN 201710397871A CN 107163420 A CN107163420 A CN 107163420A
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- titanium dioxide
- medicine bottle
- rubber plug
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
- C08L23/18—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
- C08L23/20—Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
- C08L23/22—Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefins
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/10—Applications used for bottles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Closures For Containers (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides a kind of Medical medicine bottle port rubber plug and preparation method thereof.The rubber plug material is prepared by following component and constituted：Butyl rubber, polytetrafluoroethylene (PTFE), the yellow acid amides of the benzothiazole time of the N tert-butyl groups 2, paraffin, butadiene polymer, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil, calcined kaolin, are prepared from by mixing, calendering formation, vulcanization, sterilizing, drying process.The present invention has good toughness and elastic deformation ability using base rubber, polytetrafluoroethylmaterial material, can effectively protect the reagent in bottle to ooze out；Using medical calcined kaolin, the resistance to punctural of rubber stopper can be improved；Using paraffin, butadiene polymer, make rubber stopper that there is good ageing-resistant performance.
Description
Technical field
The present invention relates to a kind of Medical medicine bottle port rubber plug, belong to medical technical equipment field.
Background technology
Medical bottleneck rubber stopper be directly with drug contact with seal-packed special rubber, therefore to its property
Can, particularly chemical property requires more strict.Rubber industry was quickly grown in recent years, hair of the rubber in field of medical materials
Also more and more extensively, the bottle stopper of many medicaments is made by elastomeric material at present, therefore height is also in the requirement to rubber performance for exhibition,
It will not only have certain toughness and corrosion resistance, also there is an excellent ageing-resistant performance, but existing Medical rubber plug
Not good with the performance of composite, resistance to acupuncture performance and mechanical property are poor, remain to be further improved.In summary, solve
It is not enough as this area technical problem urgently to be resolved hurrily that prior art is present.
The content of the invention
It is an object of the invention to provide a kind of Medical medicine bottle port rubber plug material and preparation method thereof, the material is not only
With good toughness and elastic deformation ability, also with good ageing-resistant performance and resistance to acupuncture performance.
To achieve the above object, the present invention provides following technical scheme：A kind of Medical medicine bottle port rubber plug material, it is described
Medical medicine bottle port rubber plug be made up of following raw material：80-110 parts of butyl rubber, 1-5 parts of polytetrafluoroethylene (PTFE), N-
Yellow 2-8 parts of the acid amides of the tert-butyl group -2-[4-morpholinodithio time, 5-15 parts of paraffin, 2-5 parts of butadiene polymer, 3-9 parts of resorcinol,
2-7 parts of zinc oxide, 1-3 parts of bone black, 0.3-0.7 parts of titanium dioxide, 1-4 parts of zinc stearate, 5-8 parts of titanium dioxide, mineral oil are 10-
20 parts, 70-85 parts of calcined kaolin.
Described Medical medicine bottle port rubber plug material is made up of following raw material：It is 85-105 parts of butyl rubber, poly-
2-4 parts of tetrafluoroethene, the N- tert-butyl groups -2-[4-morpholinodithio time yellow 3-7 parts of acid amides, 8-13 parts of paraffin, butadiene polymer 2-4
Part, 4-6 parts of resorcinol, 3-5 parts of zinc oxide, 1-2 parts of bone black, 0.4-0.5 parts of titanium dioxide, 1-2 parts of zinc stearate, titanium dioxide
6-8 parts, mineral oil be 12-15 parts, 75-80 parts of calcined kaolin.
Described Medical medicine bottle port rubber plug material is made up of following raw material：It is 90-100 parts of butyl rubber, poly-
2-3 parts of tetrafluoroethene, the N- tert-butyl groups -2-[4-morpholinodithio time yellow 4-6 parts of acid amides, 9-11 parts of paraffin, butadiene polymer 3-4
Part, 4-5 parts of resorcinol, 4-6 parts of zinc oxide, 1 part of bone black, 0.5 part of titanium dioxide, 1-2 parts of zinc stearate, 5-7 parts of titanium dioxide,
Mineral oil is 13-15 parts, 77-82 parts of calcined kaolin.
Further, the preparation method of described Medical medicine bottle port rubber plug material, comprises the following steps：By rubber is made
The dosage requirement of plug weighs butyl rubber, polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time yellow acid amides, paraffin, butadiene
Birds of the same feather flock together compound, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil be, calcined kaolin, and mix
Close uniform；Well mixed raw material is put into banbury and kneaded, temperature is 80-100 DEG C, and the time is 15-18min, is mixed
Refining glue inputs calender calendering formation；Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115-125 DEG C, when
Between be 15-20min, after vulcanization to semi-finished product carry out trimming, clean, sterilizing, be dried to obtain finished product.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention is had using base rubber, polytetrafluoroethylmaterial material
Good toughness and elastic deformation ability, can effectively protect the reagent in bottle to ooze out；Using medical calcined kaolin, it can improve
The resistance to punctural of rubber stopper；Using paraffin, butadiene polymer, make rubber stopper that there is good ageing-resistant performance.
Embodiment
The invention will be further elucidated with reference to specific embodiments.
Embodiment 1
A kind of medical medicine bottle port rubber rubber plug material is made up of following raw material：85 parts of butyl rubber, polytetrafluoroethylene (PTFE) 2
Part, yellow 3 parts of the acid amides of the N- tert-butyl groups -2-[4-morpholinodithio time, 7 parts of paraffin, 2 parts of butadiene polymer, 3 parts of resorcinol, oxidation
2 parts of zinc, 1 part of bone black, 0.3 part of titanium dioxide, 1 part of zinc stearate, 5 parts of titanium dioxide, mineral oil are 10 parts, calcined kaolin 70
Part.
A kind of above-mentioned Medical medicine bottle port rubber plug material preparation method, comprises the following steps：By rubber stopper is made
Dosage requirement weighs butyl rubber, polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time yellow acid amides, paraffin, butadiene type polymerization
Thing, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil and calcined kaolin, and be well mixed；
Well mixed raw material is put into banbury and kneaded, temperature is 100 DEG C, and the time is 18min, elastomeric compound input calender is obtained
Calendering formation；Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115 DEG C, and the time is 120min, right after vulcanization
Semi-finished product carry out trimming, clean, and sterilizing is dried to obtain finished product.
Embodiment 2
A kind of medical medicine bottle port rubber rubber plug material is made up of following raw material：85 parts of butyl rubber, polytetrafluoroethylene (PTFE) 2
Part, yellow 3 parts of the acid amides of the N- tert-butyl groups -2-[4-morpholinodithio time, 8 parts of paraffin, 3 parts of butadiene polymer, 4 parts of resorcinol, oxidation
3 parts of zinc, 1 part of bone black, 0.5 part of titanium dioxide, 2 parts of zinc stearate, 8 parts of titanium dioxide, mineral oil are 12 parts, calcined kaolin 80
Part.
A kind of above-mentioned Medical medicine bottle port rubber plug material preparation method, comprises the following steps：By rubber stopper is made
Dosage requirement weighs butyl rubber, polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time yellow acid amides, paraffin, butadiene type polymerization
Thing, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil and calcined kaolin, and be well mixed；
Well mixed raw material is put into banbury and kneaded, temperature is 100 DEG C, and the time is 18min, elastomeric compound input calender is obtained
Calendering formation；Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115 DEG C, and the time is 120min, right after vulcanization
Semi-finished product carry out trimming, clean, and sterilizing is dried to obtain finished product.
Embodiment 3
A kind of medical medicine bottle port rubber rubber plug material is made up of following raw material：95 parts of butyl rubber, polytetrafluoroethylene (PTFE) 3
Part, yellow 6 parts of the acid amides of the N- tert-butyl groups -2-[4-morpholinodithio time, 10 parts of paraffin, 4 parts of butadiene polymer, 5 parts of resorcinol, oxidation
6 parts of zinc, 1 part of bone black, 0.5 part of titanium dioxide, 2 parts of zinc stearate, 7 parts of titanium dioxide, mineral oil are 15 parts, calcined kaolin 82
Part.
A kind of above-mentioned Medical medicine bottle port rubber plug material preparation method, comprises the following steps：By rubber stopper is made
Dosage requirement weighs butyl rubber, polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time yellow acid amides, paraffin, butadiene type polymerization
Thing, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil and calcined kaolin, and be well mixed；
Well mixed raw material is put into banbury and kneaded, temperature is 100 DEG C, and the time is 18min, elastomeric compound input calender is obtained
Calendering formation；Molded rubber feeding vulcanizer vulcanization will be prolonged, curing temperature is 115 DEG C, and the time is 120min, right after vulcanization
Semi-finished product carry out trimming, clean, and sterilizing is dried to obtain finished product.
Although the embodiment to the present invention gives detailed description and illustrated above, it should be noted that
We can carry out various equivalent changes and modification according to the conception of the present invention to above-mentioned embodiment, and the function produced by it is made
, all should be within protection scope of the present invention during with the spirit still covered without departing from specification.
Claims (4)
1. a kind of Medical medicine bottle port rubber plug material, it is characterised in that described Medical medicine bottle port rubber plug is by following heavy
Amount part raw material is made：80-110 parts of butyl rubber, 1-5 parts of polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time yellow acid amides 2-8
Part, 5-15 parts of paraffin, 2-5 parts of butadiene polymer, 3-9 parts of resorcinol, 2-7 parts of zinc oxide, 1-3 parts of bone black, titanium dioxide
0.3-0.7 parts, 1-4 parts of zinc stearate, 5-8 parts of titanium dioxide, mineral oil be 10-20 parts, 70-85 parts of calcined kaolin.
2. the Medical medicine bottle port rubber plug material according to claim 1, it is characterised in that described medical drugses bottle
Mouth rubber stopper is made up of following raw material：85-105 parts of butyl rubber, 2-4 parts of polytetrafluoroethylene (PTFE), the N- tert-butyl group -2- benzos
Yellow 3-7 parts of the acid amides of thiazole time, 8-13 parts of paraffin, 2-4 parts of butadiene polymer, 4-6 parts of resorcinol, 3-5 parts of zinc oxide, bone
1-2 parts of charcoal, 0.4-0.5 parts of titanium dioxide, 1-2 parts of zinc stearate, 6-8 parts of titanium dioxide, mineral oil are 12-15 parts, calcining kaolinite
It is native 75-80 parts.
3. the Medical medicine bottle port rubber plug material according to claim 1, it is characterised in that described medical drugses bottle
Mouth rubber stopper is made up of following raw material：90-100 parts of butyl rubber, 2-3 parts of polytetrafluoroethylene (PTFE), the N- tert-butyl group -2- benzos
Yellow 4-6 parts of the acid amides of thiazole time, 9-11 parts of paraffin, 3-4 parts of butadiene polymer, 4-5 parts of resorcinol, 4-6 parts of zinc oxide, bone
1 part of charcoal, 0.5 part of titanium dioxide, 1-2 parts of zinc stearate, 5-7 parts of titanium dioxide, mineral oil are 13-15 parts, calcined kaolin 77-82
Part.
4. the preparation method of the Medical medicine bottle port rubber plug material according to claim 1, it is characterised in that including with
Lower step：Dosage requirement by rubber stopper is made weighs butyl rubber, polytetrafluoroethylene (PTFE), the N- tert-butyl groups -2-[4-morpholinodithio time Huang
Acid amides, paraffin, butadiene polymer, resorcinol, zinc oxide, bone black, titanium dioxide, stearic acid, titanium dioxide, mineral oil
For, calcined kaolin, and it is well mixed；Well mixed raw material is put into banbury and kneaded, temperature is 80-100 DEG C, time
For 15-18min, elastomeric compound input calender calendering formation is obtained；Molded rubber feeding vulcanizer vulcanization, vulcanization temperature will be prolonged
Spend for 115-125 DEG C, the time is 15-20min, trimming is carried out to semi-finished product after vulcanization, clean, sterilizing is dried to obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710397871.5A CN107163420A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical medicine bottle port rubber plug material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710397871.5A CN107163420A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical medicine bottle port rubber plug material and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107163420A true CN107163420A (en) | 2017-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710397871.5A Pending CN107163420A (en) | 2017-05-31 | 2017-05-31 | A kind of Medical medicine bottle port rubber plug material and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107722476A (en) * | 2017-11-08 | 2018-02-23 | 江阴市海华橡塑有限公司 | A kind of acid and alkali-resistance medical rubber stopper elastomeric material and plug preparation technology |
| CN114835980A (en) * | 2022-06-07 | 2022-08-02 | 安徽中马橡塑制品有限公司 | Medical antibacterial anti-puncturing rubber plug and preparation method thereof |
| CN114907650A (en) * | 2022-06-07 | 2022-08-16 | 安徽中马橡塑制品有限公司 | Special rubber plug suitable for sensitive medicine |
-
2017
- 2017-05-31 CN CN201710397871.5A patent/CN107163420A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107722476A (en) * | 2017-11-08 | 2018-02-23 | 江阴市海华橡塑有限公司 | A kind of acid and alkali-resistance medical rubber stopper elastomeric material and plug preparation technology |
| CN107722476B (en) * | 2017-11-08 | 2020-09-01 | 江阴市海华橡塑有限公司 | Acid and alkali resistant medical rubber plug rubber material and rubber plug preparation process |
| CN114835980A (en) * | 2022-06-07 | 2022-08-02 | 安徽中马橡塑制品有限公司 | Medical antibacterial anti-puncturing rubber plug and preparation method thereof |
| CN114907650A (en) * | 2022-06-07 | 2022-08-16 | 安徽中马橡塑制品有限公司 | Special rubber plug suitable for sensitive medicine |
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Application publication date: 20170915 |