CN112316012A - 一种舒润抑菌凝胶及其制备方法 - Google Patents
一种舒润抑菌凝胶及其制备方法 Download PDFInfo
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- CN112316012A CN112316012A CN202011306655.3A CN202011306655A CN112316012A CN 112316012 A CN112316012 A CN 112316012A CN 202011306655 A CN202011306655 A CN 202011306655A CN 112316012 A CN112316012 A CN 112316012A
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- parts
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- ethanol
- gel
- bacteriostatic
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Abstract
本申请涉及妇科抑菌凝胶领域,具体公开了一种舒润抑菌凝胶及其制备方法,所述舒润抑菌凝胶由包含以下重量份的原料制成:金银花95‑105份;蜂胶45‑55份;薄菏精油8‑12份;透明质酸钠8‑12份;玫瑰精油0.5‑1.5份;苦参碱2‑4份;苯扎溴铵0.5‑1.5份;甘油10‑15份;三乙醇胺13‑17份;卡波姆12‑16份;尼泊金乙酯2.5‑3.5份;纯化水补足至1000份。本申请具有提高凝胶的抑菌效果的优点。
Description
技术领域
本申请涉及妇科抑菌凝胶领域,更具体地说,它涉及一种舒润抑菌凝胶及其制备方法。
背景技术
妇科凝胶是一种妇科药品,为凝胶剂,用于各种妇科***炎、***的治疗,包括:细菌性***炎、滴虫性***炎、混合性***炎、***感染、慢性***。具有消炎、杀菌、止痒作用。对金黄色葡萄球菌、大肠杆菌、***、白色念珠球菌、真菌、酵母菌等病原体微生物的生长有明显抑制作用。
相关技术中一般采用一种具有抑菌成分的中药搭配润滑剂、表面活性剂、增稠剂、防腐剂和水共同制成凝胶。
针对上述中的相关技术,发明人认为凝胶的抑菌效果有待提升。
发明内容
为了提高凝胶的抑菌效果,本申请提供一种舒润抑菌凝胶及其制备方法。
第一方面,本申请提供一种舒润抑菌凝胶,采用如下的技术方案:
一种舒润抑菌凝胶,所述舒润抑菌凝胶由包含以下重量份的原料制成:
金银花95-105份;
蜂胶45-55份;
薄菏精油8-12份;
透明质酸钠8-12份;
玫瑰精油0.5-1.5份;
苦参碱2-4份;
苯扎溴铵0.5-1.5份;
甘油10-15份;
三乙醇胺13-17份;
卡波姆12-16份;
尼泊金乙酯2.5-3.5份;
纯化水补足至1000份。
通过采用上述技术方案,金银花含有绿原酸、木犀草素苷等药理活性成分,可以抑制细菌体内蛋白质合成,对溶血性链球菌、金黄葡萄球菌、大肠杆菌、白色念珠菌等多种致病菌等有较强的抑制力,另外还可增强免疫力、消炎。蜂胶有润肤生肌、消炎止痛的功效,还具有抗菌、消炎、止痒、抗氧化、增强免疫的作用,对大肠杆菌、金黄色葡萄球菌、白色念珠菌、绿脓杆菌等有抑制作用。薄荷精油对大肠杆菌、金黄葡萄球菌、白色念珠菌有明显的抗菌活性,还可以排除体内毒素,具有清凉及镇定的效果,能收缩微血管,对发痒、发炎和灼伤具有舒缓作用。本申请采用金银花、蜂胶和薄荷精油复配使用时,可以协同增效,显著提高抑菌率。
可选的,所述舒润抑菌凝胶的原料还包括15-20份的紫草。
通过采用上述技术方案,紫草具有抗菌、抗炎作用,对金黄色葡萄球菌、大肠杆菌、白色念珠菌有抑制作用。能加速上皮生长,局部应用可促进创伤愈合,紫草能够进一步提高抑菌凝胶的抑菌效果。
可选的,所述舒润抑菌凝胶的原料还包括8-10份的仙鹤草。
通过采用上述技术方案,仙鹤草具有抗菌、抗炎作用,对枯草杆菌、金黄色葡萄球菌、大肠杆菌、白色念珠菌、绿脓杆菌、福氏痢疾杆菌及伤寒杆菌等均有抑制作用,该作用与仙鹤草中含有能生成缩合型鞣酐的鞣质有关,仙鹤草能够进一步提高抑菌凝胶的抑菌效果。
可选的,所述舒润抑菌凝胶的原料还包括14-18份的土茯苓。
通过采用上述技术方案,土茯苓对金黄色葡萄球菌、白色葡萄球菌、绿脓杆菌、大肠杆菌、白色念珠菌、伤寒杆菌、甲型链球菌、乙型链球菌均有明显的抑菌作用,土茯苓能够进一步提高抑菌凝胶的抑菌效果。
可选的,所述舒润抑菌凝胶由包含以下重量份的原料制成:
金银花100份;
蜂胶50份;
薄菏精油10份;
透明质酸钠10份;
玫瑰精油1份;
苦参碱3份;
苯扎溴铵1份;
甘油12.6份;
三乙醇胺15份;
卡波姆15份;
尼泊金乙酯3份;
纯化水补足至1000份。
通过采用上述技术方案,原料的配比按照上述特定比例进行复配时,可以得到较好的抑菌效果。
第二方面,本申请提供一种舒润抑菌凝胶的制备方法,采用如下的技术方案:
一种舒润抑菌凝胶的制备方法,包括以下步骤:
(1)将尼泊金乙酯用乙醇溶解,得到第一溶液;
(2)取金银花、蜂胶加水煎煮多次,过滤,合并滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏;
(3)取卡波姆、苦参碱,加入纯化水浸泡至少24小时,至充分溶胀,得到凝胶基质;
(4)将第一溶液、纯化浸膏加入到凝胶基质中,再加入苯扎溴铵、透明质酸钠、甘油、玫瑰精油、薄荷精油搅拌均匀,补加纯化水至足量,滴入三乙醇胺调至pH至6-7,搅拌混匀,得到舒润抑菌凝胶。
通过采用上述技术方案,尼泊金乙酯用乙醇溶解后更容易分散,金银花、蜂胶一起进行提取得到第一溶液,将第一溶液、纯化浸膏加入到凝胶基质中后,再加入其它原料,可以促进水相成分和油相成分分散、混合均匀,三乙醇胺调节pH至6-7,降低了抑菌凝胶的刺激性。
可选的,所述步骤(2)具体包括:取金银花、蜂胶加水煎煮两次,第一次加7-8倍重量的纯化水,煎煮1-2小时;第二次加6-7倍重量的纯化水,煎煮1-2小时,过滤,合并两次滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏。
通过采用上述技术方案,两次煎煮可以充分提取金银花中的有效成分,醇沉可以除去杂质保留有效成分,活性炭脱色后可以使凝胶更加透明。
可选的,所述步骤(2)具体包括:取金银花、蜂胶、紫草、仙鹤草、土茯苓加水煎煮多次,过滤,合并滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏;其中,紫草、仙鹤草、土茯苓的重量份数分别为15-20份、8-10份、14-18份。
通过采用上述技术方案,采用金银花、蜂胶和薄荷精油复配使用时,可以协同增效,提高抑菌率;增加了紫草、仙鹤草和土茯苓后,紫草、仙鹤草和土茯苓复配使用,可以协同增效,进一步提升抑菌率。
综上所述,本申请具有以下有益效果:
1、由于本申请采用采用金银花、蜂胶和薄荷精油复配使用时,可以协同增效,显著提高抑菌率。
2、本申请中优选加入了紫草、仙鹤草和土茯苓,紫草、仙鹤草和土茯苓复配使用,可以协同增效,进一步提升抑菌率。
具体实施方式
以下结合实施例对本申请作进一步详细说明。
实施例
实施例1
一种舒润抑菌凝胶,原料的重量与配比如表1所示。舒润抑菌凝胶的制备方法,包括以下步骤:
(1)将尼泊金乙酯用乙醇溶解,得到第一溶液;
(2)取金银花、蜂胶加水煎煮两次,第一次加8倍重量的纯化水,煎煮1.5小时;第二次加6倍重量的纯化水,煎煮1小时,过滤,合并两次滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏;
(3)取卡波姆、苦参碱,加入纯化水浸泡24小时,至充分溶胀,得到凝胶基质;
(4)将第一溶液、纯化浸膏加入到凝胶基质中,再加入苯扎溴铵、透明质酸钠、甘油、玫瑰精油、薄荷精油搅拌均匀,补加纯化水至足量,滴入三乙醇胺调至pH至7,搅拌混匀,得到舒润抑菌凝胶。
实施例2-4
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料及其相应的重量如表1所示。
表1实施例1-4中的原料及其重量(g)
实施例5
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括15g紫草,步骤(2)中紫草与金银花、蜂胶一起加水煎煮两次。
实施例6
一种舒润抑菌凝胶,与实施例5的不同之处在于,紫草的重量为18g。
实施例7
一种舒润抑菌凝胶,与实施例5的不同之处在于,紫草的重量为20g。
实施例8
一种舒润抑菌凝胶,与实施例5的不同之处在于,紫草的重量为10g。
实施例9
一种舒润抑菌凝胶,与实施例5的不同之处在于,紫草的重量为43g。
实施例10
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括8g仙鹤草,步骤(2)中仙鹤草与金银花、蜂胶一起加水煎煮两次。
实施例11
一种舒润抑菌凝胶,与实施例10的不同之处在于,仙鹤草的重量为9g。
实施例12
一种舒润抑菌凝胶,与实施例10的不同之处在于,仙鹤草的重量为10g。
实施例13
一种舒润抑菌凝胶,与实施例10的不同之处在于,仙鹤草的重量为5g。
实施例14
一种舒润抑菌凝胶,与实施例10的不同之处在于,仙鹤草的重量为43g。
实施例15
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括14g土茯苓,步骤(2)中土茯苓与金银花、蜂胶一起加水煎煮两次。
实施例16
一种舒润抑菌凝胶,与实施例15的不同之处在于,土茯苓的重量为16g。
实施例17
一种舒润抑菌凝胶,与实施例15的不同之处在于,土茯苓的重量为18g。
实施例18
一种舒润抑菌凝胶,与实施例15的不同之处在于,土茯苓的重量为10g。
实施例19
一种舒润抑菌凝胶,与实施例15的不同之处在于,土茯苓的重量为43g。
实施例20
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括18g紫草和25g仙鹤草,步骤(2)中紫草、仙鹤草与金银花、蜂胶一起加水煎煮两次。
实施例21
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括27g仙鹤草和16g土茯苓,步骤(2)中仙鹤草、土茯苓与金银花、蜂胶一起加水煎煮两次。
实施例22
一种舒润抑菌凝胶,与实施例1的不同之处在于,原料还包括18g紫草、9g仙鹤草和16g土茯苓,步骤(2)具体包括:取金银花、蜂胶、紫草、仙鹤草、土茯苓加水煎煮两次,第一次加8倍重量的纯化水,煎煮1.5小时;第二次加6倍重量的纯化水,煎煮1小时,过滤,合并两次滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏。
对比例
对比例1
一种舒润抑菌凝胶,与实施例1的不同之处在于,蜂胶和薄荷精油替换为等重量的金银花。
对比例2
一种舒润抑菌凝胶,与实施例1的不同之处在于,金银花和薄荷精油替换为等重量的蜂胶。
对比例3
一种舒润抑菌凝胶,与实施例1的不同之处在于,金银花和蜂胶替换为等重量的薄荷精油。
对比例4
一种舒润抑菌凝胶,与实施例1的不同之处在于,金银花的重量为60g。
对比例5
一种舒润抑菌凝胶,与实施例1的不同之处在于,蜂胶的重量为30g。
对比例6
一种舒润抑菌凝胶,与实施例1的不同之处在于,薄荷精油的重量为20g。
性能检测试验
试验方法:按照GB15979-2002《一次性使用卫生用品卫生标准》附录C4以及《消毒技术规范》2002版中的试验条件,测试实施例1-22和对比例1-6中的抑菌凝胶对大肠杆菌(8099)、白色念珠菌(ATCC10231)、金黄色葡萄球菌(ATCC6538)作用5min时的抑菌率,试验重复三次,取平均值,抑菌试验为载体试验,试验温度20℃±1℃。
实施例1-22中抑菌凝胶的微生物学指标和***粘膜刺激试验均符合《一次性使用卫生用品卫生标准》以及《消毒技术规范》2002版的相关要求。
表2抑菌率测试结果
结合实施例1-22和对比例1-6并结合表2可以看出,实施例1-3采用金银花、蜂胶和薄荷精油复配,对三种致病菌的抑菌率均在90%以上,说明本申请的抑菌凝胶具有较强抑菌作用。对比例1仅采用金银花时,抑菌率仅有60%左右,对比例2仅采用蜂胶时,抑菌率仅有61%左右,对比例3仅采用薄荷精油时,抑菌率仅有60%左右,说明金银花、蜂胶和薄荷精油单独使用时,抑菌效果较弱,但是实施例1将金银花、蜂胶和薄荷精油复配使用时,可以协同增效,显著提高抑菌率。
对比例4-6中,金银花、蜂胶和薄荷精油的用量不在本申请的范围内时,抑菌率有一定的下降,说明金银花、蜂胶和薄荷精油的用量会影响抑菌率。
实施例4改变了原料的配比后,抑菌率与实施例1相比提高了1%左右,说明原料的配比按照实施例4进行复配时,可以得到较好的抑菌效果。
实施例5-7在实施例1的基础上增加了紫草后,抑菌率明显提升,说明紫草能够进一步提高抑菌凝胶的抑菌效果,实施例8加入的紫草较少时,抑菌率提升较少,实施例9加入的紫草超过本申请的最高用量时,抑菌率没有明显提升,反而造成成本上升,说明紫草的用量在15-20份时能够较好的提高抑菌效果。
实施例10-12在实施例1的基础上增加了仙鹤草后,抑菌率明显提升,说明仙鹤草能够进一步提高抑菌凝胶的抑菌效果,实施例13加入的仙鹤草较少时,抑菌率提升较少,实施例14加入的仙鹤草超过本申请的最高用量时,抑菌率没有明显提升,反而造成成本上升,说明仙鹤草的用量在8-10份时能够较好的提高抑菌效果。
实施例15-17在实施例1的基础上增加了土茯苓后,抑菌率明显提升,说明土茯苓能够进一步提高抑菌凝胶的抑菌效果,实施例18加入的土茯苓较少时,抑菌率提升较少,实施例19加入的土茯苓超过本申请的最高用量时,抑菌率没有明显提升,反而造成成本上升,说明土茯苓的用量在14-18份时能够较好的提高抑菌效果。
实施例20在实施例1的基础上增加了紫草和仙鹤草后,抑菌率明显提高,但是没有发现有协同作用,说明紫草和仙鹤草复配,可以共同提高抑菌效果,但是没有协同作用;实施例21在实施例1的基础上增加了仙鹤草和土茯苓后,抑菌率明显提高,但是没有发现有协同作用,说明仙鹤草和土茯苓复配,可以共同提高抑菌效果,但是没有协同作用;实施例22在实施例1的基础上增加了紫草、仙鹤草和土茯苓后,发现抑菌率明显提高,而且具有协同增效的作用,说明紫草、仙鹤草和土茯苓复配使用时,可以协同增效,显著提升抑菌率。
本具体实施例仅仅是对本申请的解释,其并不是对本申请的限制,本领域技术人员在阅读完本说明书后可以根据需要对本实施例做出没有创造性贡献的修改,但只要在本申请的权利要求范围内都受到专利法的保护。
Claims (8)
1.一种舒润抑菌凝胶,其特征在于,所述舒润抑菌凝胶由包含以下重量份的原料制成:
金银花95-105份;
蜂胶45-55份;
薄菏精油8-12份;
透明质酸钠8-12份;
玫瑰精油0.5-1.5份;
苦参碱2-4份;
苯扎溴铵0.5-1.5份;
甘油10-15份;
三乙醇胺13-17份;
卡波姆12-16份;
尼泊金乙酯2.5-3.5份;
纯化水补足至1000份。
2.根据权利要求1所述的一种舒润抑菌凝胶,其特征在于:所述舒润抑菌凝胶的原料还包括15-20份的紫草。
3.根据权利要求1所述的一种舒润抑菌凝胶,其特征在于:所述舒润抑菌凝胶的原料还包括8-10份的仙鹤草。
4.根据权利要求1所述的一种舒润抑菌凝胶,其特征在于:所述舒润抑菌凝胶的原料还包括14-18份的土茯苓。
5.根据权利要求1所述的一种舒润抑菌凝胶,其特征在于:所述舒润抑菌凝胶由包含以下重量份的原料制成:
金银花100份;
蜂胶50份;
薄菏精油10份;
透明质酸钠10份;
玫瑰精油1份;
苦参碱3份;
苯扎溴铵1份;
甘油12.6份;
三乙醇胺15份;
卡波姆15份;
尼泊金乙酯3份;
纯化水补足至1000份。
6.权利要求1-5中任一项所述的一种舒润抑菌凝胶的制备方法,其特征在于:包括以下步骤:
(1)将尼泊金乙酯用乙醇溶解,得到第一溶液;
(2)取金银花、蜂胶加水煎煮多次,过滤,合并滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏;
(3)取卡波姆、苦参碱,加入纯化水浸泡至少24小时,至充分溶胀,得到凝胶基质;
(4)将第一溶液、纯化浸膏加入到凝胶基质中,再加入苯扎溴铵、透明质酸钠、甘油、玫瑰精油、薄荷精油搅拌均匀,补加纯化水至足量,滴入三乙醇胺调至pH至6-7,搅拌混匀,得到舒润抑菌凝胶。
7.根据权利要求6所述的一种舒润抑菌凝胶的制备方法,其特征在于:所述步骤(2)具体包括:取金银花、蜂胶加水煎煮两次,第一次加7-8倍重量的纯化水,煎煮1-2小时;第二次加6-7倍重量的纯化水,煎煮1-2小时,过滤,合并两次滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏。
8.根据权利要求6所述的一种舒润抑菌凝胶的制备方法,其特征在于:所述步骤(2)具体包括:取金银花、蜂胶、紫草、仙鹤草、土茯苓加水煎煮多次,过滤,合并滤液,加热浓缩至60℃下相对密度为1.1-1.2的浸膏,加入乙醇使乙醇体积浓度达到75%,搅拌混匀,醇沉,静置至少24h,取上清液回收乙醇至无醇味,加入纯化水,再加入活性炭脱色,得到纯化浸膏;其中,紫草、仙鹤草、土茯苓的重量份数分别为15-20份、8-10份、14-18份。
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