CN112206304A

CN112206304A - Susceptible constitution conditioning composition and preparation method thereof

Info

Publication number: CN112206304A
Application number: CN202011138408.7A
Authority: CN
Inventors: 牟方政; 郑邦本
Original assignee: Three Gorges Hospital Affiliated To Chongqing University
Current assignee: Three Gorges Hospital Affiliated To Chongqing University
Priority date: 2020-10-22
Filing date: 2020-10-22
Publication date: 2021-01-12

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a susceptible constitution conditioning composition which comprises the following raw materials in parts by weight: 9-30 parts of adenophora tetraphylla, 10-35 parts of astragalus membranaceus, 9-28 parts of fried bighead atractylodes rhizome, 1-5 parts of liquorice, 5-18 parts of ginger, 5-10 parts of ageratum, 9-15 parts of poria cocos, 5-10 parts of dried orange peel and 5-10 parts of perilla leaf. The invention also provides a preparation method of the susceptible constitution conditioning composition. The susceptible constitution conditioning composition provided by the invention has the effects of expelling wind, removing cold, removing dampness and enhancing physical strength, and has a good effect of preventing new crown pneumonia.

Description

Susceptible constitution conditioning composition and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a susceptible constitution conditioning composition and a preparation method thereof.

Background

The sudden new coronary pneumonia has strong infectivity and high pathogenic rate, and no specific medicine can treat the new coronary pneumonia at present. Under such large circumstances, prevention is an important part of epidemic prevention and control strategies.

The history of traditional Chinese medicine for preventing infectious diseases is long, and the record of the classic traditional Chinese medicine book Huangdi's internal classic: if the healthy qi is not infected with each other, the pathogenic qi cannot be dried, and the pathogenic qi is kept away, i.e., the body's healthy qi needs to be kept away from the pathogenic qi to resist the exogenous pathogenic qi. Therefore, there is a need to develop a Chinese medicinal composition with high safety, significant efficacy, low side effects, low treatment cost, and effective prevention of new coronavirus.

The application publication number CN111603504A of the Chinese invention discloses a Chinese medicinal composition for preventing new crown pneumonia, which comprises 8-18g of raw astragalus root, 8-18g of fried bighead atractylodes rhizome, 8-15g of divaricate saposhnikovia root, 8-15g of mulberry leaf, 8-15g of wrinkled gianthyssop herb, 5-10g of platycodon root, 8-15g of cyrtomium rhizome and 3-6g of raw liquorice. In the patent, the astragalus root has the functions of tonifying qi, invigorating yang, strengthening the exterior and suppressing sweating; the divaricate saposhnikovia root has the effects of dispelling wind, relieving exterior syndrome, eliminating dampness and relieving spasm; the mulberry leaves, the agastache rugosus and the platycodon grandiflorum play roles in dispelling wind and heat, relieving exterior syndrome and eliminating dampness; the platycodon root plays a role in ventilating the lung and eliminating phlegm; the cyrtomium rhizome has the function of killing insects; the mulberry leaf, the platycodon root and the raw liquorice have the effects of clearing lung and relieving sore throat, and are decocted for oral administration or carried with people by using granules.

Although the above patent can play a better role in preventing, the above patent has a poor effect in conditioning listlessness, fatigue, weakness, appetite reduction and sleep disorder of people with susceptible constitution. In essence, the susceptible constitution group is the key group for epidemic prevention and control. The susceptible constitution people refer to people with low immunity, and are very easy to cause bacterial, viral and fungal infection in daily life. The most direct manifestations of susceptible people are easy illness, usually accompanied by constitutional debility, malnutrition, listlessness, fatigue, weakness, appetite decrease, sleep disorder, etc.

In addition, the traditional Chinese medicine composition provided by the patent is mainly used for clinical treatment, is not used for prevention of both medicine and food, and cannot be used for daily conditioning of susceptible people.

Disclosure of Invention

The invention aims to provide a composition which can be used as both medicine and food, has the effects of expelling wind, removing cold and removing dampness, enhancing the physical strength of people with susceptible constitution, strengthening spleen and stomach and improving the appetite of people with susceptible constitution, and a preparation method thereof.

In order to achieve the purpose, the invention provides a susceptible constitution conditioning composition, which comprises the following raw materials in parts by weight: 9-30 parts of adenophora tetraphylla, 10-35 parts of astragalus membranaceus, 9-28 parts of fried bighead atractylodes rhizome, 1-5 parts of liquorice, 5-18 parts of ginger, 5-10 parts of ageratum, 9-15 parts of poria cocos, 5-10 parts of dried orange peel and 5-10 parts of perilla leaf.

The invention also provides a preparation method of the susceptible constitution conditioning composition, which comprises the following steps: the method comprises the following steps: weighing the raw materials according to a certain proportion, adding water, decocting to prepare oral liquid, or spraying and solidifying the water decoction to obtain instant granules.

The invention also provides a preparation method of another susceptible constitution conditioning composition, which is prepared into a medicine bag for use, or is soaked in edible alcohol for 11-15 days, filtered to obtain medicinal liquor, packaged and stored for use as a bath.

The principle and the beneficial effects of the technical scheme are as follows:

on one hand, the susceptible constitution conditioning composition provided by the invention is used for conditioning the susceptible constitution from the aspects of dispelling wind, dispelling cold and removing dampness, and the specific principle is as follows: the new coronary pneumonia belongs to cold-dampness plague in traditional Chinese medicine, has the characteristics of cold evil and dampness evil, and preferably selects traditional Chinese medicine with warm property.

The principle of the susceptible constitution conditioning composition for expelling wind, removing cold and removing dampness provided by the invention is as follows: A. radix astragali, fried rhizoma atractylodis macrocephalae and ginger in a specific proportion are taken as main materials, so as to strengthen the exterior and tonify the lung qi; B. the adenophora tetraphylla, the fried bighead atractylodes rhizome, the poria cocos and the liquorice in a specific proportion have the effects of tonifying spleen and lung and strengthening body resistance; C. and herba Agastaches, folium Perillae, pericarpium Citri Tangerinae and Glycyrrhrizae radix at a certain ratio for eliminating pathogenic factor.

Secondly, the susceptible constitution conditioning composition provided by the invention mainly starts from enhancing physical strength and strengthening spleen and stomach, and is supplemented with eliminating evil and relieving cough to condition susceptible constitution groups for the following reasons:

compared with the population with normal immunity, the susceptible constitution population is more worried about the illness, and the mind is more panic, so that the establishment of the confidence of the susceptible constitution population is more important, and the illness is often represented by shortness of breath, hypodynamia, poor appetite and loose stool as the initial expression, so that the susceptible constitution conditioning composition provided by the invention is mainly started from the aspect of enhancing the physical strength, enhances the physical strength of the susceptible constitution population, is supplemented with the functions of strengthening the spleen and invigorating the stomach, and enhances the gastrointestinal tract digestive ability of the susceptible constitution population, thereby remarkably reducing the fear of the susceptible constitution population and helping the establishment of the confidence of the defeating epidemic situation.

The adenophora tetraphylla, the astragalus membranaceus, the fried bighead atractylodes rhizome, the liquorice and the ginger in the susceptible constitution conditioning composition in a specific proportion mainly play a role in enhancing physical strength, and 5-10 parts of wrinkled gianthyssop herb, 9-15 parts of poria cocos and 5-10 parts of dried orange peel in a specific proportion are supplemented to play a role in strengthening the spleen and stomach.

Thirdly, the fried bighead atractylodes rhizome, the poria cocos and the liquorice in the susceptible constitution conditioning composition provided by the invention also have the effects of strengthening spleen, tonifying qi, eliminating dampness, promoting diuresis, promoting sleep and conditioning qi and blood.

Fourthly, the perilla leaf, the adenophora tetraphylla, the ginger and the liquorice in the specific proportion in the susceptible constitution conditioning composition provided by the invention also have the effects of warming the lung, relieving cough and detoxifying.

Fifthly, the wrinkled gianthyssop herb, the perilla leaf, the dried orange peel and the liquorice in a specific proportion in the susceptible constitution conditioning composition provided by the invention can also be used as an evil dispelling agent, and the effects of aromatic diaphoresis, cold dispelling and dampness resolving are achieved, and cold evil is treated and enters the interior to attack the stomach.

Sixthly, all the raw materials of the susceptible constitution conditioning composition provided by the invention basically belong to medicinal and edible Chinese herbal medicines.

Compared with the existing composition added with the divaricate saposhnikovia root, the invention adopts the ginger to replace the non-medicinal and edible divaricate saposhnikovia root, and the health care requirement of the people with the susceptible constitution is better met.

Preferably, the invention also provides a susceptible constitution conditioning composition, which also comprises 3-10 parts of platycodon grandiflorum.

Preferably, the susceptible constitution conditioning composition also provided by the invention further comprises 6-15 parts of bupleurum.

Preferably, the invention also provides a susceptible constitution conditioning composition, which further comprises 5-8 parts of angelica dahurica.

Preferably, the invention also provides a susceptible constitution conditioning composition, which also comprises 10 to 32 parts of cassia twig.

The raw materials used in the invention are detailed as follows:

the astragalus root used in the invention is the root of leguminous plant astragalus mongholicus and astragalus membranaceus, has sweet taste and mild nature, and enters spleen and lung channels.

The fried bighead atractylodes rhizome used in the invention is a perennial herb of Atractylodes of Compositae, bitter, sweet and warm.

The ginger used in the invention is fresh rhizome of Zingiber officinale Roscoe of Zingiberaceae, has pungent taste and mild nature, and enters lung, spleen and stomach meridians.

The wrinkled gianthyssop herb used in the invention is the overground part of the cablin potchouli herb which is a herbal plant in the family of labiate, has pungent taste and warm nature, and enters spleen, stomach and lung meridians.

The perilla leaf used in the invention is the stem and leaf of perilla leaf of Labiatae, and the perilla belongs to annual herbaceous plants, is warm in nature and pungent in taste, and enters lung and spleen channels. Each 100 g of tender stem and leaf contains 23mg of ferrum, 3.0mg of calcium, 44mg of phosphorus, 9.09mg of carotene, 10.02mg of vitamin B, 20.35mg of vitamin B, 47mg of vitamin C and 1.3mg of nicotinic acid. The seed contains 25% protein and contains various amino acids.

The adenophora tetraphylla used in the invention is dry root of adenophora tetraphylla of Campanulaceae, has sweet taste and slightly cold property, and enters lung and stomach channels.

The tuckahoe used in the invention is dry sclerotium of tuckahoe which is a fungus of Polyporaceae, has sweet and light taste and neutral nature, and enters heart, lung, spleen and kidney meridians.

The tangerine peel used in the invention is mature peel of Rutaceae plant tangerine and its cultivar, and has pungent, bitter and warm properties. It enters spleen and lung meridians.

The liquorice used in the invention is the dried root and rhizome of the liquorice of leguminous plants, has sweet taste and mild nature, and enters heart, lung, spleen and stomach channels.

The platycodon grandiflorum used in the invention is the dried root of platycodon grandiflorum of the family platycodon, is a Chinese medicinal material used as both medicine and food, and is bitter, pungent and mild; entering lung meridian, it has the actions of dispersing lung qi, relieving sore throat, eliminating phlegm and discharging pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, etc. The production place of the platycodon grandiflorum adopted by the invention is preferably the old soil village in Chongqing Wanzhou area.

The bupleurum used by the invention is the dried root of bupleurum or bupleurum stenophyllum of Umbelliferae, and has the efficacies of tonifying liver and kidney, soothing liver and benefiting gallbladder. Bitter, pungent and slightly cold; it enters liver and gallbladder meridians.

The radix bupleuri used in the invention is the root of angelica dahurica of Umbelliferae, and has warm nature and pungent taste.

The cassia twig used in the invention is pungent, sweet and warm in nature, enters lung, heart and bladder channels, is a commonly used interior-warming medicine for mainly treating interior cold, has the effects of tonifying primordial yang, promoting blood circulation and warming spleen and stomach, and is often combined with liver and kidney tonifying medicines and qi and blood tonifying medicines to condition kidney yang deficiency, decline of vital gate fire and slight cold limbs and pulse.

The cassia twig, the radix bupleuri, the ginger and the platycodon grandiflorum in specific proportions have obvious liver tonifying effect, and can remarkably condition the complexion of people with susceptible constitution

White and sallow complexion, low voice and short breath.

Detailed Description

The following is further detailed by way of specific embodiments:

example 1

The embodiment provides a susceptible constitution conditioning composition, which comprises the following raw materials in parts by weight: 15 parts of astragalus membranaceus, 15 parts of fried bighead atractylodes rhizome, 10 parts of ginger, 10 parts of ageratum, 10 parts of perilla leaf, 15 parts of adenophora tetraphylla, 15 parts of poria cocos, 10 parts of dried orange peel and 5 parts of liquorice.

The preparation method of the susceptible constitution conditioning composition comprises the following steps: weighing the raw materials according to a certain proportion, decocting together, and finally adding water to decoct together to prepare oral liquid (the weight part of the added water is 1.2 times of the weight part of all the raw materials and the dosage is 600ml per day), or spraying and solidifying the water decoction to prepare instant granules; the oral liquid is taken by 100 ml per day and 300ml per day, and the oral liquid is preferably taken by 200ml per day in the embodiment.

The above composition can be used as medicated bag.

The above composition can also be soaked in edible alcohol for 11-15 days, filtered to obtain medicated liquor, packaged and stored, and used as bath.

Examples 2 to 11

Examples 2-5 differ from example 1 only in that: the weight parts of the raw materials of the examples 2 to 5 are different from those of the example 1;

example 6 differs from example 1 only in that: example 6 further comprises 8 parts of platycodon grandiflorum; the platycodon grandiflorum of example 6 is south platycodon grandiflorum, and the origin is old soil village in Chongqing Wanzhou region;

example 7 differs from example 2 only in that: example 7 also includes 8 parts of bupleurum;

example 8 differs from example 3 only in that: embodiment 8 further comprises 12 parts of radix angelicae;

example 9 differs from example 4 only in that: example 9 further comprises 12 parts of cassia twig;

example 10 differs from example 5 only in that: embodiment 10 also includes 8 parts of platycodon grandiflorum, 8 parts of radix bupleuri, 12 parts of radix angelicae and 12 parts of cassia twig.

Example 10 differs from example 11 only in that: the platycodon grandiflorum of example 10 is south platycodon grandiflorum, the origin is Chongqing Fengjie, the platycodon grandiflorum of example 10 is south platycodon grandiflorum, and the origin is Chongqing Wanzhou old soil village.

Specific starting materials for examples 1-11 are shown in the following table:

comparative examples 1 to 4

Comparative example 1 differs from example 1 only in that: comparative example 1 no astragalus, roasted atractylodes and ginger were added;

comparative example 2 differs from example 2 only in that: comparative example 2 no parched Atractylodis rhizoma, radix Adenophorae, Poria and Glycyrrhrizae radix were added;

comparative example 3 differs from example 2 only in that: comparative example 3 no pericarpium Citri Reticulatae, radix Glycyrrhizae, herba Pogostemonis, and folium Perillae were added;

comparative example 4 differs from example 11 only in that: comparative example 4 no ginger, bupleurum and cassia twig were added;

the compositions of comparative examples 1-4 specifically included the following raw materials as shown in the table:

experiment one

(1) Preparing oral liquid

The oral liquid prepared from the susceptible constitution composition of example 1-9 is administered once a day, 200ml each time, during the period of 1 month and 25 days in 2020 to 3 months and 14 days in 2020.

(2) Experimental methods

In the experiment, the low-immunity workers with symptoms of weak constitution, malnutrition, reduced appetite, listlessness, fatigue, easy fatigue and sleep disorder are selected as the experimental objects, the number of the finally determined susceptible persons is 1500, the susceptible persons are divided into 15 groups, and the specific grouping conditions are shown in the following table:

(3) adverse reaction

After the medicine is taken, no side effect exists, and no abnormality exists in the liver and kidney function physical examination.

(4) Results of the experiment

From the above table it can be derived:

(1) the experimental group 11 (oral liquid prepared in comparative example 1) lacks the astragalus, the fried atractylodes macrocephala koidz and the ginger which have the effects of strengthening the exterior and tonifying lung qi compared with the experimental group 1 (oral liquid prepared in oral example 1), but the experimental group 11 has poor effects of conditioning the weak constitution, fatigue, weakness, fatigue, chest distress, cough and abdominal distension, and also has poor effects of conditioning the inappetence, the sleep disorder, the poor appetite and the loose stool, and proves that the astragalus, the fried atractylodes macrocephala koidz and the ginger in the experimental group 1 have the synergistic effects of conditioning the inappetence, the sleep disorder and the poor appetite and the loose stool with other raw materials.

(2) The experimental group 12 (oral administration of the oral liquid prepared in comparative example 2) did not contain the parched white atractylodes rhizome, adenophora tetraphylla, poria cocos and licorice, which have the effects of strengthening the spleen, strengthening the lung and strengthening the body resistance, compared with the experimental group 2 (oral administration of the oral liquid prepared in example 2), but the experimental group 12 had poor effects of conditioning physical weakness, fatigue, chest distress, cough and abdominal distension, and also had poor effects of conditioning inappetence, sleep disorder, anorexia and loose stool, and it was proved that the parched white atractylodes rhizome, adenophora tetraphylla, poria cocos and licorice in the experimental group 2 also have synergistic effects of anorexia, sleep disorder and loose stool with the remaining raw materials.

(3) Compared with the experimental group 13 (oral liquid prepared by the comparative example 3), the experimental group 2 (oral liquid prepared by the example 2) does not add tangerine peel, liquorice, agastache and perilla leaf which have the function of eliminating evil, and compared with the experimental group 2, the experimental group 13 has long effect time on conditioning the weak constitution, fatigue and weakness, easy fatigue, chest distress, cough and abdominal distension, appetite reduction, sleep disorder and poor appetite and loose stool.

(4) The probability of alleviation is better in experimental group 15 (oral liquid prepared in example 11) and the effect is surprisingly faster in experimental group 1-experimental group 10, compared with experimental group 15.

Compared with the experimental group 15, the experimental group 10 and the experimental group 15 adopt the balloonflower root (experimental group 15) of Chongqing Wanzhou to treat complexion

White, sallow complexion, low voice and short breath, and hypodynamia.

(5) The experimental group 15 (oral liquid prepared in oral example 11) did not add the function of conditioning the complexion of the people with susceptible constitution compared with the experimental group 14 (oral liquid prepared in comparative example 4)

Compared with the experimental group 15, the experimental group 14 recuperates the complexion except for the sallow complexion, the low voice and the weak qi and the shortness of breath of the ginger, the Chinese thorowax root and the cassia twig

The pale and sallow complexion, low voice and weak qi, and poor effect of qi shortness and hypodynamia, which indicates that ginger, Bupleurum root, cinnamon twig and other herbsThe rest raw materials have the synergistic effect of conditioning physical weakness, fatigue, weakness, easy fatigue, chest distress, cough, abdominal distension, inappetence, sleep disorder, poor appetite and loose stool.

(6) Compared with the experimental group 6 (the oral liquid prepared in the example 6), the experimental group 15 (the oral liquid prepared in the oral example 11) does not add radix bupleuri, radix angelicae dahuricae and cassia twig, and the experimental group 15 has the effects of conditioning weak constitution, fatigue and weakness, fatigue, chest distress, cough, abdominal distension, inappetence, sleep disorder and complexion

The relieving probability of white, sallow complexion, low voice and shortness of breath and hypodynamia is higher, and the miraculous effect is quicker.

Experiment two

The oral liquids prepared in examples 1 to 11 were dispensed to 326 patients suspected of new coronary pneumonia, all lung ventilation and air exchange functions were conditioned after taking the oral liquids, symptoms disappeared, and all tests were negative.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. A susceptible constitution conditioning composition is characterized by comprising the following raw materials in parts by weight: 9-30 parts of adenophora tetraphylla, 10-35 parts of astragalus membranaceus, 9-28 parts of fried bighead atractylodes rhizome, 1-5 parts of liquorice, 5-18 parts of ginger, 5-10 parts of ageratum, 9-15 parts of poria cocos, 5-10 parts of dried orange peel and 5-10 parts of perilla leaf.

2. The susceptible body conditioning composition of claim 1, further comprising 3-10 parts of Platycodon grandiflorum.

3. The susceptible constitution conditioning composition according to claim 1 or 2, further comprising 6-15 parts of bupleurum.

4. The susceptible constitution conditioning composition according to claim 1 or 2, further comprising 5-8 parts of angelica dahurica.

5. The susceptible body conditioning composition of claim 3, further comprising 5-8 parts of radix Angelicae Dahuricae.

6. The susceptible body conditioning composition of claim 1, 2 or 5, further comprising 10-32 parts of cassia twig.

7. The susceptible body conditioning composition of claim 3, further comprising 10-32 parts of cinnamon twig.

8. A method of preparing a susceptible body conditioning composition according to any one of claims 1 to 7 comprising the steps of: weighing the raw materials according to a certain proportion, adding water, decocting to prepare oral liquid, or spraying the water decoction to solidify into instant granules.

9. The method for preparing a susceptible constitution conditioning composition according to any one of claims 1 to 7, wherein the composition is formulated into a medicated bag for use, or is soaked in edible alcohol for 11 to 15 days, filtered to obtain medicated wine, packaged and stored, and used as a bath.