CN112206017A

CN112206017A - Valve clamping device easy to clamp and valve clamping system

Info

Publication number: CN112206017A
Application number: CN201910632959.XA
Authority: CN
Inventors: 张庭超; 张伟伟; 郑贤章
Original assignee: Hangzhou Valgen Medtech Co Ltd
Current assignee: Hangzhou Valgen Medtech Co Ltd
Priority date: 2019-07-12
Filing date: 2019-07-12
Publication date: 2021-01-12

Abstract

The invention provides an easily-clamped valve clamping device and a valve clamping system. The valve clamping device comprises a push rod, at least two clamp arms and at least one extension arm, wherein the push rod moves axially to drive the clamp arms to open and close relative to the push rod and drive the extension arm to extend or retract along the axial direction of the clamp arms. According to the valve clamping device, the telescopic extension arm is arranged on the surface of the clamp arm of the valve clamping device, and the extension arm extends out of the clamp arm when the clamp arm is opened relative to the push rod of the valve clamping device, so that the length of the clamp arm is increased, the longer clamp arm can play a good supporting effect on valve leaflets when the valve leaflets are captured, the valve leaflets are prevented from slipping off from the surface of the clamp arm, the movable valve leaflets can be captured quickly, the operation difficulty is reduced, and the operation efficiency is improved.

Description

Valve clamping device easy to clamp and valve clamping system

Technical Field

The invention relates to the field of medical equipment, in particular to an easily-clamped valve clamping device and a valve clamping system.

Background

Referring to fig. 1, a mitral valve 1 is a one-way valve between the left atrium 2 and the left ventricle 3 of the heart, and a normal and healthy mitral valve 1 can control blood flow from the left atrium 2 to the left ventricle 3 while preventing blood flow from the left ventricle 3 to the left atrium 2. The mitral valve includes a pair of leaflets, referred to as the anterior leaflet 1a and the posterior leaflet 1 b. The anterior leaflet 1a and the posterior leaflet 1b are fixed to the inner wall of the left ventricle 3 by chordae tendineae 4. Normally, when the left ventricle of the heart contracts, the edges of the anterior leaflet 1a and the posterior leaflet 1b are completely apposed, preventing blood from flowing from the left ventricle 3 to the left atrium 2. Referring to fig. 2, when the leaflets of the mitral valve or their associated structures are partially broken by organic or functional changes (e.g., chordae tendineae 4), the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve are poorly coaptated, and when the left ventricle of the heart contracts, the mitral valve 1 cannot be completely closed, resulting in regurgitation of blood from the left ventricle 3 to the left atrium 2, which causes a series of pathophysiological changes called "mitral regurgitation".

The existing minimally invasive treatment surgery is characterized in that a valve leaflet clamp is conveyed to a mitral valve through a conveying device, and an anterior leaflet and a posterior leaflet of the mitral valve are clamped simultaneously through relative opening and closing of the clamp, so that the anterior leaflet and the posterior leaflet of the mitral valve are fixed, and the purpose of reducing mitral regurgitation is achieved. However, since the two leaflets of the mitral valve are always in a large-amplitude and large-force opening and closing movement state, the difficulty of the clamp to quickly and successfully capture the moving leaflet tissue is high, and the operation time is long.

Disclosure of Invention

The present invention is directed to provide an easily-clamped valve clamping device and a valve clamping system, which can easily and rapidly capture moving valve leaflet tissue, thereby reducing the difficulty of the operation and improving the efficiency of the operation.

The valve clamping device easy to clamp comprises a push rod, at least two forceps arms and at least one extension arm. The clamp arm comprises a fixed end and a free end, the fixed end is connected with the push rod, and the push rod moves axially to drive the clamp arm to open and close relative to the push rod by taking the fixed end as a rotating center; the extension arm extends or retracts along the axial direction of the forceps arms, and when the extension arm extends towards the direction of the free end along the fixed end of the forceps arms, the tail end of the extension arm exceeds the free end of the forceps arms.

The valve clamping system comprises a pushing device and the valve clamping device easy to clamp, the pushing device comprises an operating handle and a pushing shaft with a certain axial length, the near end of the pushing shaft is connected with the operating handle, and the far end of the pushing shaft is detachably connected with the valve clamping device.

According to the valve clamping device and the valve clamping system which are easy to clamp, the extension arm capable of extending or retracting along the axial direction of the clamp arm is arranged, so that when the clamp arm is opened relative to the push rod, the tail end of the extension arm exceeds the free end of the clamp arm, namely the length of the clamp arm when the valve leaflet is captured is increased, the longer clamp arm can play a good supporting effect on the valve leaflet when the valve leaflet is captured, the valve leaflet is prevented from slipping off the surface of the clamp arm, movable valve leaflet tissues are rapidly captured, the operation difficulty is reduced, and the operation efficiency is improved.

Drawings

To more clearly illustrate the structural features and effects of the present invention, a detailed description is given below with reference to the accompanying drawings and specific embodiments.

FIG. 1 is a schematic view of a mitral valve in a normal state;

FIG. 2 is a schematic representation of a diseased mitral valve;

FIG. 3 is a schematic view of a collapsible valve binder according to an embodiment of the present invention;

FIG. 4 is a schematic view of the valve clip of FIG. 3 from a perspective when the arms are open;

FIG. 5 is a schematic view of the valve clip of FIG. 3 from another perspective with the arms open;

FIG. 6 is a schematic view of the position of the valve holder of the present invention at the mitral valve;

FIG. 7a is a schematic representation of a mitral valve during systole after the valve clasper of the present invention has clasped leaflets;

FIG. 7b is a schematic representation of a mitral valve at diastole after the valve clasper clamps leaflets according to the present invention;

FIG. 8 is a schematic view of the push rod of the valve binder shown in FIG. 3;

FIG. 9 is a schematic view of the fixed base of the valve clip of FIG. 3;

FIG. 10 is a schematic view of the base connector of the valve holder of FIG. 3;

FIG. 11 is a schematic structural view of the forceps arms of the valve clip of FIG. 3;

FIG. 12a is a schematic view of the valve clip of FIG. 3 with the grasping arms collapsed;

FIG. 12b is a schematic view of the valve clip of FIG. 3 with the grasping arms expanded;

FIG. 13 is a schematic view of the structure of the extension arms of the valve binder shown in FIG. 3;

figures 14a to 14e are schematic structural views of the carrying part of the extension arms of the valve clip according to different embodiments of the present invention;

FIG. 15 is a schematic view of the valve binder of the embodiment of FIG. 14 c;

FIG. 16 is a schematic view of a valve clip of another embodiment of the present application;

FIG. 17 is a schematic structural view of the clamp arms of the valve clamp of the embodiment shown in FIG. 16;

FIG. 18 is a schematic structural view of the clamp arms of a valve clamp according to another embodiment of the present application;

FIG. 19 is a schematic view of the valve clip in an open position with the arms of the clip coupled to the delivery shaft according to one embodiment of the present disclosure;

FIG. 20 is a schematic cross-sectional view of the valve clip of FIG. 19 shown attached to the delivery shaft;

FIG. 21 is a schematic view of the valve clip in an expanded configuration with the clip arms of the valve clip coupled to the delivery shaft according to an embodiment of the present application;

figure 22 is a cross-sectional schematic view of the valve clip of figure 21 attached to the push shaft.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. The drawings are for illustrative purposes only and are merely schematic representations, not intended to limit the present patent. It is emphasized that in this application the term "proximal" refers to a direction towards the operator; "distal" means away from the operator.

Referring to fig. 3 to 5, the present invention provides an easy-to-clamp valve clamping device 100. Valve clamp 100 includes push rod 40, two clamp arms 11, at least one extension arm 20. In this embodiment, the number of the forceps arms 11 is two, and the two forceps arms 11 are arranged axially symmetrically with respect to the push rod 40 and can be opened and closed with respect to the push rod 40. The valve clip 100 of the present invention can be used for edge-to-edge repair of mitral regurgitation, and specifically, referring to fig. 6, the valve clip 100 is placed at a position of the anterior leaflet and the posterior leaflet of the mitral valve where they cannot be normally coaptated, such that one of the forceps arms 11 supports the edge of the anterior leaflet 1a of the mitral valve, the other forceps arm 11 supports the edge of the posterior leaflet 1b of the mitral valve, and the positions of the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve where they cannot be normally coaptated are fixed together by the two forceps arms 11. Fig. 7a is a schematic view showing the mitral valve in a contracted state, wherein the direction of the arrows is the blood flow direction. When the heart contracts, the anterior leaflet 1a and the posterior leaflet 1b are closed, and the edge of the anterior leaflet 1a and the edge of the posterior leaflet 1b are clamped by the valve clamp 100, so that the mitral valve can be completely closed or the area of the opening becomes small, thereby reducing or treating "mitral regurgitation". Referring to fig. 7b, fig. 7b is a schematic diagram illustrating a mitral valve state during diastole, wherein the direction of the arrow is a blood flow direction. When the heart is in diastole, the anterior leaflet 1a and the posterior leaflet 1b are only fixed together at the position where the valve clamping device 100 is clamped, and other positions of the anterior leaflet 1a and the posterior leaflet 1b are still in normal diastole, so that a large amount of blood can enter the left ventricle from the left atrium, and the normal flow of the blood is ensured. Valve binder 100 of other embodiments of the present invention can also be used to reduce or treat "tricuspid regurgitation," i.e., three arms 11 of valve binder 100, with three leaflets held together by three arms 11, thereby reducing or avoiding "tricuspid regurgitation. The principle and structure of the valve clip device 100 are the same as those of the valve clip device 100 for solving mitral regurgitation in the embodiment of the present invention, and detailed description thereof is omitted. It is understood that the valve clamping device 100 of other embodiments of the present invention can also be applied to other minimally invasive surgical operations requiring clamping of several pieces of tissue together, and the number of the forceps arms 11 is varied according to actual use requirements.

Referring to fig. 3 and 8, the push rod 40 is a rod-shaped structure, and the push rod 40 moves along the axial direction to push the forceps arm 11 to open and close relative to the push rod 40, and drive the extension arm 20 to move, so as to extend or retract the distal end of the extension arm 20 to the forceps arm 11. Fig. 8 shows a structure of a push rod 40 according to an embodiment of the present application. The push rod 40 includes a round rod section 41 and a square rod section 42 connected to a distal end of the round rod section 41. The cross section of any position in the axial direction of the round rod section 41 is circular, and the cross section of any position in the axial direction of the square rod section 42 is square. The push rod 40 has racks 421 on opposite surfaces of the square rod section 42. The rack 421 is a concave-convex tooth-shaped structure formed on the surface of the square rod section 42. The proximal end of the push rod 40 is looped with a slot 411. The proximal end of the rod section 41 is annularly provided with an annular groove 411, and the end face of the proximal end of the rod section 41 is provided with a threaded hole 412 towards the inner direction of the push rod 40. It is understood that in some embodiments, the push rod 40 may also be a round rod or a square rod, i.e., the cross section of the push rod 40 at any position in the axial direction is round or square.

In some embodiments of the present application, a base 43 is provided on the distal end of the push rod 40. The base 43 includes two opposite first surfaces 431 and a second surface 432 connecting the two first surfaces 431. The distal end of the push rod 40 is fixed to the second surface 432, and both the first surfaces 431 are provided with a gap 433. The inner walls of two opposite sides of the gap 433 are provided with pin holes 434.

The outer surface of the base 43 is smooth, thereby facilitating the smooth advancement of the base 43 in the valve clamp 100 and preventing the base 43 from damaging human tissue or hooking chordae tendineae. The base 43 may have any shape, such as a rectangular parallelepiped, a hemisphere, a spherical cap, or a bullet. In the present embodiment, the base 43 has a rectangular parallelepiped shape. Preferably, the base 43 has a cross-sectional dimension that decreases from the proximal end to the distal end in a direction parallel to the second plane 412, so that the valve clip 100 is more easily advanced in vivo.

The push rod 40 and the base 43 are made of biocompatible materials. The biocompatible material is selected from stainless steel, cobalt alloy or titanium alloy, preferably titanium alloy.

Referring to fig. 3 and 9, in some embodiments of the present application, the valve clip 100 further includes a fixing base 50. Fig. 9 is a schematic structural diagram of a fixing base 50 according to an embodiment of the present application. The fixed base 50 comprises two opposite clamping plates 51, and the two clamping plates 51 are connected through two connecting rods 52 arranged at intervals. The two connecting rods 52 and the two splints 51 enclose a through channel 53, and the push rod 40 is inserted into the through channel 53 and can move axially in the through channel 53.

Referring to fig. 3 and 10, in some embodiments of the present application, the valve clamping device 100 further includes a base connecting tube 60, and the base connecting tube 60 is sleeved outside the push rod 40 and fixed to the fixing base 50. The base connection tube 60 has an opening 61, and the opening 61 has a spring 62 therein. The elastic sheet 62 includes a connection end and a free end opposite to the connection end, and the connection end is connected to the edge of the opening 61. In the natural state, the free end is inclined toward the inside of the base connection pipe 60 with respect to the connection section. When the forceps arm 11 is folded on the push rod 40, the free end of the elastic piece 62 is clamped in the clamping groove 411 at the proximal end of the push rod 40, so as to prevent the push rod 40 from moving in the axial direction, and prevent the forceps arm 11 from being opened relative to the push rod 40.

Further, the proximal end of the base connection tube 60 is provided with a connection portion 63 for connecting with a pushing device for pushing the valve clip 100 to the heart valve. In some embodiments, the connecting portion 63 is a T-shaped groove, and the T-shaped groove includes a first groove segment 631 and a second groove segment 632 intersecting the first groove segment 631. The first groove section 631 extends in the same axial direction as the base connection tube 60 and extends from the end surface of the proximal end of the base connection tube 60 to the distal end of the proximal end of the base connection tube 60.

Referring back to fig. 3 to 5, the clamp arm 11 is opened and closed relative to the clamp arm 12 or the push rod 40 to clamp or release the valve leaflet. Referring to fig. 8 and 11 together, fig. 11 is a schematic structural diagram of the clamp arm 11 according to some embodiments of the present application. Each of the forceps arms 11 includes a fixed end 11a at a distal end and a free end 11b at a proximal end, and the forceps arm 11 is opened and closed with respect to the push rod 40 with the fixed end 11a as a rotation center. Specifically, the fixed end 11a of the clamp arm 11 has a gear 111, and the gear 111 is engaged with a rack 421 on the push rod 40. The fixed end 11a of the jawarm 11 is located between the two clamping plates 51 of the fixed base 50, and the gear 111 is axially rotatably coupled to the two clamping plates 51. Specifically, the gear 111 is provided with a through pin hole 114 along the axial direction, and the two clamp plates 51 are correspondingly provided with fixing holes 54. The pin 122 passes through the pin hole 114 and both ends of the pin 122 are fixed in the fixing holes 54 of the chucking plate 51, respectively. When the push rod 40 moves in the axial direction due to the engagement between the gear 111 and the rack 421, the gear 111 rotates about the pin 122, and the caliper arm 11 rotates about the gear 111 to open and close with respect to the push rod 40. Specifically, when the push rod 40 axially moves towards the distal end, the rack 421 drives the gear 111 to rotate, so that the jawarms 11 are folded relative to the push rod 40; when the push rod 40 is axially moved proximally, the rack 421 rotates the gear 111 to open the jawarms 11 relative to the push rod 40.

In some embodiments of the present application, the included angle between the two jawarms 11 ranges from 0 ° to 200 °, that is, the two jawarms in the initial state (closed) are parallel to each other, and the included angle is 0 °, and by the engagement of the rack 421 of the push rod 40 and the gear 111 of the jawarms 11, the opening range of the included angle between the two jawarms 11 in a larger range can be realized, the included angle between the two opened jawarms 11 can reach 200 ° at most, and by setting the specific specification of the engagement of the gear 111 and the rack 421, the maximum included angle between the two opened jawarms 11 is preferably 150 °. The size range of the opening of the jaw can reach 20-36mm, which is beneficial to clamping the valve leaf. In addition, the opening and closing of the two clamp arms 11 are carried out at a constant speed, so that an operator can adjust the positions of the clamp arms 11 in real time according to the relative position between the valve clamping device 100 and the valve leaflets in the clamping process, and the problem that the clamping fails due to the slippage of the valve leaflets caused by too fast or too slow clamping is avoided. In addition, the size of the included angle between the two corresponding forceps arms 11 can be known through the feed stroke of the push rod 40, which is beneficial for the clamping judgment of an operator.

It is understood that in other embodiments of the present application, the fixed ends 11a of the two jawarms 11 can be rotatably connected to the push rod 40 by a pin or a bolt, so that the two jawarms 11 can be rotatably opened and closed relative to the push rod 40.

In some embodiments, the jawarms 11 are provided with a plurality of spaced apart through holes. By providing the through holes on the forceps arms 11, the weight of the forceps arms 11 can be reduced, and the creeping and growing of endothelial cells can be facilitated.

Jawarm 11 includes a first surface 112a facing push rod 40. In some embodiments, a grip enhancer 113 is provided on the first surface 112a to enhance the friction between the jawarms 11 and the leaflets when the jawarms 11 cooperate with the pushrod 40 to grip the leaflets, thereby providing a stable gripping force. The clamping reinforcement member 113 may be a protrusion, a groove, or a pad made of a biocompatible material with a high friction coefficient, which is attached to the first surface 112a, provided on the first surface 112 a.

The jawarms 11 have certain dimensional specifications in order to ensure a stable clamping force and to adapt to the size of the leaflets. Specifically, when the forceps arm 11 is too long, the forceps arm 11 is easy to clamp the excessive anterior leaflet 1a and the posterior leaflet 1b together, and the two leaflets are forcibly pulled toward each other and fixed together, which not only easily causes dysfunction of the mitral valve, but also may cause serious consequences such as tearing of the leaflets due to the limited movement of the excessive leaflets during heartbeat and movement of the leaflets; when the clamp arm 11 is too short, only a small part of the valve leaflets can be clamped, so that the valve leaflets easily slide out, and the clamping and fixing effects are poor. In addition, as the valve leaflets are soft, the clamp arms 11 are not easy to support the valve leaflets or cooperate with the clamp arms 12 to clamp the valve leaflets in the clamping process, so that the operation time is prolonged. In some embodiments of the present application, the axial length of the jawarm 11 (i.e., the distance from the fixed end 11a to the free end 11 b) should be greater than or equal to 4mm, preferably 6-10 mm. The width of the clamp arm 11 is also limited to a certain extent so as to prevent the valve leaflet from being damaged due to the excessively narrow width of the clamp arm 11 and to prevent the valve leaflet from being moved when the width of the clamp arm 11 is excessively wide. The width of the jawarms 11 (i.e. the length in a direction perpendicular to the axial direction of the jawarms 11) should be greater than or equal to 2mm, preferably 4-6 mm. In addition, in order to ensure the safety after implantation, the forceps arms 11 should be made of a biocompatible material and have certain flexibility and rigidity, so as to prevent the forceps arms 11 from damaging the valve leaflets, and simultaneously clamp and fix the valve leaflets. In particular, the biocompatible material is selected from stainless steel, cobalt alloys or titanium alloys.

Further, the first surfaces 112a of the arms 11 may also be coated with an active agent or provided with a plurality of openings to promote endothelial cell coating and growth of valve tissue on the inner surfaces of the arms 11. Further, the first surface 112a may also be configured as a concave-convex surface having a concave-convex structure, so as to increase the friction force between the forceps arms 11 and the valve leaflets and improve the fixation capability of the valve binder 100 on the valve leaflets.

Referring back to fig. 3 to 5, in an embodiment of the present application, the valve clamping device 100 includes a resilient clamping member, which includes two clamping arms 12. Two clamping arms 12 of the clamping piece correspond to the two clamp arms 11 respectively, each clamping arm 12 is located between the corresponding clamp arm 11 and the push rod 40, and each clamp arm 11 is involuted with one clamping arm 12 to clamp the valve leaflets.

Referring to fig. 3, 12a and 12b, fig. 12a is a schematic structural view of a clamping member in a tightened (conveying) state according to some embodiments of the present application; figure 12b shows a schematic view of the clamp of some embodiments of the present application in its natural (released) state. The clamping piece is cut by a material such as a nickel-titanium alloy or a cobalt-chromium alloy sheet metal, and then placed into a shaping mold, and the shape shown in fig. 12b is obtained through heat shaping treatment. Due to its elasticity, the clip can be delivered in a catheter in the state shown in fig. 12a and, after unbounded, returns to the state shown in fig. 12b, thereby clamping the leaflets in cooperation with the jawarms 11. Each clamping arm 12 of the clamp comprises a free end 12a and a fixed end 12b arranged opposite each other. The fixed end 12b is fixed to the fixed base 50. In some embodiments, the fixing end 12b is fixed between the fixing base 50 and the base connection pipe 60. In some embodiments, the fixing ends 12b of the two holding arms 12 are connected to each other by a connecting piece 12c to form a unitary structure (i.e., the holding member is U-shaped), and the connecting piece 12c is fixedly connected to the fixing base 50 in a detachable or non-detachable manner, so as to fix the fixing ends 12b of the two holding arms 12 to the fixing base 50. In some embodiments of the present application, the retaining arms 12 are at least partially formed from a resilient material such as nitinol. In one embodiment of the present application, the fixed end 12b of the holding arm 12 is made of an elastic material. The free ends 12a of the holding arms 12 may be made of an inelastic material such as an aluminum alloy, so long as the holding arms 12 are secured in a natural state and in a tightened state by heat setting. Naturally, the holding arm 12 is disposed at an angle to the push rod 40. The angle between the two arms 12 is in the range of 0-160. In some embodiments, the included angle between the two clamping arms 12 should be slightly larger than the included angle between the two clamping arms 11 to provide a more stable clamping force, that is, the included angle between each clamping arm 12 and the push rod 40 is greater than or equal to the included angle between the corresponding clamping arm 12 and the corresponding clamping arm 11 when the corresponding clamping arm 11 is opened to the maximum, so as to ensure that a certain clamping force exists between the clamping

arms

11 and 12 to clamp the leaflet between the clamping

arms

11 and 12. It will be appreciated that in some embodiments, the angle between the retaining arm 12 and the push rod 40 may be less than the angle between the jawarms 11 and the push rod 40 when the jawarms 11 are fully extended.

The free end 12a of the clamp arm 12 is connected with a control member 13 in the pushing device, and the free end 12a of the clamp arm 12 is controlled by the control member 13 to adjust the angle between the clamp arm 12 and the push rod 40 and the opening and closing between the clamp arm 12 and the clamp arm 11. In this embodiment, the control member 13 is an adjusting wire made of a polymer material such as metal or PTFE, and the adjusting wire passes through the free ends 12a of the clamping arms 12 to bind the clamping arms 12 to the surface of the push rod 40, so that the two clamping arms 12 are in a tightened state, and are beneficial to being transported through a curved blood vessel through a catheter; after the positions of the clamp arms 11 and the valve leaflets are adjusted, the control of the adjusting lines on the free ends 12a of the clamping arms 12 is released, the free ends 12a of the clamping arms 12 rebound to two sides and are far away from the push rod 40 due to the elastic memory performance of the free ends 12a, at the moment, the clamping arms 12 are in a natural state, and the clamping arms 12 and the clamp arms 11 clamp the valve leaflets between the clamping arms 12 and the valve leaflets.

Further, the clamp arm 12 includes a third surface 12d opposite the jawarms 11. The third surface 12d is provided with a clamping enhancing member 121 to increase the friction between the clamping arm 12 and the leaflet clamped between the clamping arm 11 and the clamping arm 12, and to improve the clamping force of the clamping arm 11 and the clamping arm 12 to the leaflet. The gripping enhancer 121 can be a ridge, barb, boss, or other irregularly distributed protrusion protruding from the third surface 12d, or can be a rough surface at least partially covering the third surface 12d to improve the gripping force of the valve binder 100 against the valve leaflets. For example, covering the outer surface of the push rod 40 with a spacer made of a biocompatible material having a higher coefficient of friction increases the surface roughness of the third surface 12d, thereby improving the gripping force of the valve binder 100 against the valve leaflets. The grip reinforcement member 121 may be a magnetic member provided on the grip arm 12, and in this case, a corresponding magnetic member is provided on the clamp arm 11, so that the grip strength is enhanced by the mutual magnetic attraction between the clamp arm 11 and the grip arm 12.

In one embodiment of the present application, the clamping reinforcement 121 is two rows of spaced apart teeth. Two rows of convex teeth are oppositely arranged on the two side edges of the clamping arm 12. And the angle between the axial direction of each tooth and the third surface 12d is less than or equal to 90 deg. to further enhance the clamping force. Further, the end of the convex tooth away from the third surface 12d is a smooth arc-shaped surface, so as to avoid damaging the valve leaflet. In this embodiment, since the clamping arm 12 is provided with the protruding teeth, in order to avoid the effect of the protruding teeth on the involution of the clamp arm 11 and the clamping arm 12, the width of the clamp arm 11 is smaller than the width of the clamping arm 12, so that when the clamp arm 11 and the clamping arm 12 are involuted, the protruding teeth on the clamping arm 12 are both located at two sides of the clamp arm 11, and the first surface 112a of the clamp arm 11 contacts with the third surface 12d of the clamping arm 12, so that the clamp arm 11 and the clamping arm 12 can clamp the leaflet located between the clamp arm 11 and the clamping arm 12 more stably. Further, in some embodiments, the clamping arm 12 is provided with a through hole 122 to reduce the weight of the clamping arm 12, enhance the elasticity of the clamping arm 12, and facilitate the creeping and growth of endothelial cells.

Referring back to fig. 3 to 5, at least one extension arm 20 is provided. The extension arm 20 is disposed on the surface or within the jawarms 11. In one embodiment of the present invention, two extension arms 20 are respectively disposed on the surfaces of the two forceps arms 11. Specifically, the extension arm 20 can be disposed on a first surface 112a of the jawarm 11 (i.e., an inner surface of the jawarm 11) or on a second surface opposite the first surface 112a (i.e., an outer surface of the jawarm 11). In some embodiments, the extension arm 20 is disposed within the interior of the jawarms 11. Specifically, the caliper arm 11 is provided with a through hole extending from the fixed end 11a to the free end 11b, and the extension arm 20 is inserted into the through hole, so that the extension arm 20 is disposed inside the caliper arm 11. In this embodiment, the extension arm 20 is disposed on a second surface of the jawarms 11. Specifically, the second surface of the jawarm 11 is provided with a limiting member 14, and the limiting member 14 is used for limiting the extension direction of the extension arm 20 to be a direction from the fixed end 11a to the free end 11b of the jawarm 11, so as to limit the radial offset of the extension arm 20. The limiting member 14 may be a limiting ring, a limiting groove, a limiting pipe, or other limiting structures. Preferably, the limiting member 14 is a limiting ring or a limiting tube, and the extending arm 20 can be fixed to the second surface of the jawarm 11 through the limiting member 14, so as to prevent the extending arm 20 from being separated from the second surface during the movement process. Specifically, in the present embodiment, the limiting member 14 is a tubular member with a certain length, and the extension arm 20 is movably disposed through the tubular member.

Referring to fig. 13, in some embodiments of the present application, the extension arm 20 includes a fixed end 20a and a free end 20b opposite to each other, and the fixed end 20a is rotatably fixed to the distal end of the push rod 40. In one embodiment of the present application, the fixed end 20a is rotatably fixed to a base 43 at the distal end of the pushing rod 40. The fixed end 20a of the extension arm 20 is located in the notch 411 in the base 43. And the fixed end 20a has a pin hole 114 thereon, the pin passes through the pin hole 114 and both ends of the pin are fixed to the inner wall of the notch 411, thereby achieving the rotational fixation of the fixed end 20a to the base 43. When the push rod 40 is pushed in the axial direction, the push rod 40 brings the end of the extension arm 20 beyond the free end 11a of the jawarm 11. Specifically, when the push rod 40 axially moves towards the distal end, the tail end of the extension arm 20 can be driven to retract along the axial direction of the forceps arm 11; as the push rod 40 is moved axially proximally, the distal end of the extension arm 20 is caused to extend axially along the jawarms 11. Meanwhile, in some embodiments of the present application, the axial movement of the push rod 40 can drive the forceps arm 11 to open and close relative to the push rod 40, so that the axial movement of the push rod 40 can be achieved, and the opening and closing of the forceps arm 11 relative to the push rod 40 and the axial extension and retraction of the extension arm 20 along the forceps arm 11 can be controlled, so that the opening and closing control of the forceps arm 11 relative to the push rod 40 and the axial extension and retraction control of the extension arm 20 relative to the forceps arm 11 can be simultaneously achieved on the premise of not increasing additional surgical operation steps, and the surgical difficulty is reduced. It will be appreciated that in other embodiments of the present application, the extension or retraction of the extension arm 20 and the opening or closing of the jawarms 11 relative to the push rod 40 may not be synchronized. For example, the jawarms 11 are connected to different drive structures with the extension arms 20 so that the jawarms 11 can be moved away from the extension arms 20 to unsynchronize extension or retraction of the extension arms 20 and opening or closing of the jawarms 11 relative to the push rods 40. Specifically, the gear 111 of the caliper arm 11 may be engaged with the rack 421 of the push rod 40, so that the caliper arm 11 is opened and closed relative to the push rod 40 by the axial movement of the push rod 40. And, another push rod is provided and the extension arm 20 is connected with the other push rod, so that the extension arm 20 is driven by the other push rod to extend or retract, that is, the jawarms 11 and the extension arm 20 are respectively controlled by the independent push rods, so that the extension or retraction of the extension arm 20 is out of synchronization with the opening or closing of the jawarms 11 relative to the push rod 40.

In some embodiments, the valve clip 100 further comprises an extension arm steel sleeve 21, and the fixed end 20a of the extension arm 20 is fixed on the extension arm steel sleeve 21 by welding or crimping. The end of the extension arm steel sleeve 21 remote from the extension arm 20 is located in the indentation 433 in the base 43. And one end of the extension arm steel sleeve 21, which is far away from the extension arm 20, is provided with a pin hole, two opposite side walls of the gap 433 are provided with fixing holes 434, the pin penetrates through the pin hole, and two ends of the pin are fixed in the fixing holes 434, so that the extension arm steel sleeve 21 and the base 43 are rotationally fixed, and further, the fixed end 20a of the extension arm 20 and the base 43 are rotationally fixed.

In the present application, the extension arm 20 extending beyond the jawarms 11 means that the end of the extension arm 20 extends beyond the free end 11b of the jawarms 11, i.e., the end of the extension arm 20 is located on the side of the free end 11b of the jawarms 11 away from the fixed end 11 a; the distal end of extension arm 20 is received into jawarm 11 in the sense that the end of extension arm 20 is retracted between free end 11b and fixed end 11a of jawarm 11. Upon axial movement of the push rod 40 in the proximal direction, the jawarms 11 open relative to the push rod 40 and the extension arms 20 extend out of the jawarms 11. When extension arm 20 stretches out tong arm 11, extension arm 20 has been equivalent to the length that has prolonged tong arm 11, and when tong arm 11 opened in order to catch the leaflet relative push rod 40, the leaflet length of support can be increased to the tong arm 11 of extension for the leaflet is difficult to follow tong arm 11 slippage, thereby makes the capture of valve clamp 100 to the leaflet easier, makes things convenient for the centre gripping. Moreover, since the actual length of the clamp arms 11 is not changed, the length of the valve clip 100 clamping the valve leaflets is not changed in practice, and the problem that the valve clip 100 is too long and may be generated is avoided. Preferably, the inner and/or outer surface of each jawarm 11 is provided with at least one extension arm 20. So that the length of each of the jawarms 11 can be lengthened to allow each of the jawarms 11 to easily capture a leaflet. In this embodiment, the whole of extension arm 20 is smooth, and the one end that stretches out tong arm 11 forms smooth button head through laser spot welding, does not have defects such as burr, edge, edges and corners, avoids the damage to the leaflet.

In some embodiments of the present invention, the extension arm 20 includes an extension arm body. The extension arm main part includes the bracing piece of one or many settings side by side to directly support the leaflet through the bracing piece. The support rod can be in a solid or hollow structure, and can also be in a single-layer or multi-layer composite structure. For example, the support rod may be a solid or hollow rod formed from one material, or may be formed by nesting hollow tubes of different materials having different inner diameters. Alternatively, the support rod may be formed by winding a single wire or a plurality of wires. The cross section of the support rod can be regular round or in the shape of ellipse, crescent, semicircle, polygon and the like, and is preferably round, so that the support rod is easy to process and can avoid the damage of the support rod to the valve leaflet. Further, in this embodiment, the support rods are made of a flexible and/or elastic biocompatible material to adapt to the anatomy of the leaflets and the range of motion of the leaflets, and to avoid damage to the leaflets. For example, a metallic material, a polymeric material, or a metal-polymer composite material may be selected. Specifically, the support rod is made of a metal-polymer composite material, and in this embodiment, nickel-titanium alloy and PTFE are used.

Further, in other embodiments of the present invention, the extension arm 20 includes an extension arm body made of a flexible material, and further includes a support body made of a rigid material, such as stainless steel or titanium alloy. The support body is arranged inside and/or outside the extension arm main body to enhance the strength of the extension arm 20, so that the extension arm 20 has certain flexibility to adapt to the anatomical structure of the valve leaflet and the movement range of the valve leaflet, and simultaneously has certain rigidity to effectively support the valve leaflet. For example, in one embodiment, the extension arm body is a flexible tube made of a softer material, the support is a rigid rod made of a harder material, and the flexible tube is sleeved over the rigid rod to form the extension arm 20, in which case the support is disposed outside of the extension arm body. Alternatively, in another embodiment of the present invention, the main body of the extension arm is a flexible rod, the support body is a rigid tube made of a material with higher hardness, and the rigid tube is sleeved outside the flexible rod to form the extension arm 20, in which case, the support body is disposed inside the main body of the extension arm. Or, in another embodiment of the present invention, the heat shrinkable tube is used as a support body to wrap the outer surface of the softer extension arm main body, and then the heat shrinkable tube is heated to shrink and wrap the outer surface of the extension arm main body to improve the support property, that is, the extension arm main body is a flexible rod, the rigid support body is a heat shrinkable tube, the heat shrinkable tube is sleeved outside the flexible rod and heated to shrink so as to be fixed with the flexible rod, and at this time, the support body is arranged outside the extension arm main body. Alternatively, in another embodiment of the present invention, the main body of the extension arm is formed by winding at least one flexible wire (e.g., stainless steel wire), and then wrapping the thermoplastic elastomer (e.g., Pebax) outside the main body of the extension arm, and then heating to melt the Pebax and cover the Pebax outside the main body of the extension arm, and meanwhile, a portion of the Pebax penetrates into the main body of the extension arm through the gap between the flexible wires, so that the support body is disposed inside and outside the main body of the extension arm.

Further, the extension arm 20 is at least partially made of a non-X-ray transmissive material. For example, extension arm main part and/or support are made by the material of nontransmissive X ray to make extension arm 20 stretch out the back from valve clamping device 100, contact with the leaflet, extension arm 20 can produce corresponding swing along with the activity range of leaflet, and the operator can judge the position of leaflet through X ray accurately fast this moment, if the position is reasonable, the operator can drive valve clamping device 100 centre gripping leaflet, thereby shortens operation time, improves the operation success rate. The non-X-ray transmitting material is selected from stainless steel or nickel-titanium alloy.

Referring to fig. 14a to 14e, fig. 14a to 14e are schematic structural views of an extension arm according to other embodiments of the present application. In these embodiments, the free end 20b of the extension arm 20 is also provided with a bearing 22. When the tail end of the extension arm 20 exceeds the free end 11b of the forceps arm 11, the width of the bearing part 22 is larger than the diameter of the extension arm 20, so that the bearing part 22 has a larger bearing area, and better bears the valve leaflets. The width direction of the support portion 22 is the same as the width direction of the caliper arm 11. The bearing part 22 may be a plate-like structure or an elastic member. As shown in fig. 14a, the supporting portion 22 has a plate-like structure, specifically, a flat plate-like shape. As shown in fig. 14b to 14e, the bearing portion 22 is an elastic member, the elastic member is compressed and in a compressed state when the extension arm 20 is retracted into the caliper arm 11, when the elastic member extends out of the caliper arm 11 along with the extension arm 20, that is, when the end of the extension arm 20 exceeds the free end of the caliper arm 11, the elastic member is no longer externally pressed and is thus unfolded and in an unfolded state, the area of the elastic member in the unfolded state is larger than that of the elastic member in the compressed state, so that the elastic member and the leaflet have a larger contact area, so as to better fit the leaflet, and improve the support of the extension arm 20 to the leaflet. Preferably, in the present invention, the plane of the elastic member after being stretched is parallel to the first surface 112a of the forceps arm 11, so that the elastic member after being stretched has a larger contact area with the valve leaflet, thereby achieving a better supporting effect on the valve leaflet. Specifically, the first plane 112a and the plane where the elastic member is stretched may be both planes or both curved surfaces.

Referring to fig. 14c, in another embodiment of the present invention, the elastic member is a deformable mesh cage. Specifically, the elastic member is a cage-shaped structure formed by weaving yarns with certain elasticity and tension. When the net cage is accommodated in the caliper arm 11, the net cage is compressed by being squeezed and deformed, and can be accommodated in the caliper arm 11. When the cylinder mould stretches out of the clamp arm 11, the cylinder mould is unfolded and is in an unfolded state, and the volume of the expanded cylinder mould is larger than that of the cylinder mould during extrusion, so that more stable support is provided for valve blades supported on the extension arm 20. In the present application, the silk threads forming the mesh cage may be metal threads having a good biocompatibility or silk threads made of a polymer material having a certain elasticity. In this example, a nickel titanium wire was used. Further, compared to the elastic member shown in fig. 14b, the elastic member of this embodiment has a three-dimensional structure, which can provide a more three-dimensional visualization effect and provide a more stable support for the leaflet supported by the extension arm 20 (as shown in fig. 16).

Referring to fig. 14c and fig. 15, in the present embodiment, the mesh cage includes a woven mesh 221, and a sealing head 222 and a fixing tube 223 fixed at two ends of the woven mesh 221, respectively. Specifically, the nickel-titanium wires form a tubular mesh grid 221, and one end of the mesh grid 221 is fixed in the end enclosure 222. That is, the cap 222 closes and fixes one open end of the mesh grid 221. The other end of the mesh net 221 is gathered and fixed in the fixing tube 223. The end of the tube 223 facing away from the mesh 221 is connected to the extension arm 20. The sealing head 222 and the fixing tube 223 can be made of metal or polymer plastic. In this embodiment, the seal head 222 is made of stainless steel.

In this embodiment, the cylinder mould is a structure in which the middle is columnar, the two ends are conical, and the conical taper angles of the two ends are the same. It will be appreciated that the netpen may be of any other shape, as is known in the art. For example, referring to fig. 14d and 14e, the netpen may be a spindle-shaped structure with the same cone angle at both ends as shown in fig. 14d, or a structure with different cone angles at both ends as shown in fig. 14 e.

Referring to fig. 16 and 17, fig. 16 shows a valve clamp 100 according to another embodiment of the present application, and fig. 17 shows a schematic structural view of the forceps arms 12 according to the embodiment shown in fig. 16. The difference between this embodiment and the embodiment shown in fig. 3 is that: the width of the jawarms 11 is greater than the width of the gripping arms 12. Moreover, the accommodating groove 15 is formed in the forceps arm 11, and when the forceps arm 11 is aligned with the clamping arm 12, the convex tooth 121 of the clamping arm 12 is just positioned in the accommodating groove 15 of the forceps arm 11, so that the clamping effect of the forceps arm 11 and the clamping arm 12 on the valve is more stable. The width of the clamp arm 11 is made larger than that of the clamping arm 12 by increasing the width of the clamp arm 11, so that the clamping area of the clamp arm 11 and the clamping arm 12 for clamping the valve leaflet is increased, the clamping force is more dispersedly exerted on the valve leaflet, and the strain on the valve is reduced; moreover, the first surface 112a of the clamp arm 11 can be attached to the third surface 12d of the clamp arm 12, so that the outer diameter of the valve clamp 100 is smaller when the clamp arm 11 is attached to the push rod 40, thereby facilitating the delivery process of the valve clamp 100. In this embodiment, the width of the clamp arm 11 is increased to 6 mm.

Further, in some embodiments, the forceps arm 11 is provided with a through hole 115, and the through hole 115 is disposed in the accommodating groove 15, so as to facilitate the covering of endothelial cells by disposing the through hole 115. It will be appreciated that in some embodiments, as shown in figure 18, the jawarms 11 may be formed without the apertures 115.

Referring to fig. 19 and 20, the present invention further provides a valve clamping system, which includes a pushing device and the valve clamp 100, wherein the valve clamp 100 can be delivered to the mitral valve by the pushing device, and the valve clamp 100 can be adjusted to a proper position of the mitral valve. The pushing device comprises an operating handle for an operator to hold and a pushing shaft which is connected with the distal end of the operating handle and has a certain axial length, the proximal end of the pushing shaft is connected with the operating handle, and the distal end of the pushing shaft is detachably connected with the valve clamping device 100. Specifically, the pushing shaft includes a mandrel 210, a liner tube 220 sleeved outside the mandrel 210, and an outer tube 230 sleeved outside the liner tube 220. The operating handle can drive the mandrel 210, the liner 220 and the outer tube 230 to move relatively.

The distal end of spindle 210 has external threads 211 that correspond to the internal threads in threaded bore 412 in the proximal end of push rod 40. When the pushing shaft is connected with the valve clamping device 100, the distal end of the mandrel 210 is in threaded connection with the proximal end of the pushing rod 40, and the mandrel 210 is driven to move by operating the handle, so that the pushing rod 40 moves along the axial direction.

The distal end of the outer tube 230 is provided with a T-shaped resilient tab 231 for engaging with the T-shaped slot 63 of the base connection tube 60 to connect and disconnect the outer tube 230 and the base connection tube 60. In a natural state, one end of the T-shaped spring is connected to the distal end of the outer tube 230, and the other end is inclined toward the axis of the outer tube 230. Specifically, when the pushing shaft is connected to the valve clamp 100, the mandrel 210 is in threaded connection with the push rod 40, the operation handle drives the liner tube 220 to move, so that when the liner tube 220 extends into the base connecting tube 60, the liner tube 220 jacks up the T-shaped elastic piece 231 of the outer tube 230, so that the T-shaped elastic piece 231 is embedded into the T-shaped groove 63 of the base connecting tube 60, and at this time, the base connecting tube 60 and the outer tube 230 are in a connected state; when the operating handle is operated to remove the sleeve 220 from the base connector 60, the T-shaped resilient piece 231 of the outer tube 230 is in a natural state, i.e., deformed inwardly and disengaged from the T-shaped groove 63, so that the base connector 60 is unlocked from the outer tube 230.

The following description of the operation method of the valve clamping system of the present invention is given by taking the mitral valve repair process as an example, and mainly comprises the following steps:

the first step is as follows: the pusher shaft is connected to the valve clip 100. The spindle 210 of the push shaft is rotated so that the spindle 210 is fixed with the push rod 40. And the sleeve 220 is axially moved towards the distal end to jack up the T-shaped spring 231 of the outer tube 230 so that the T-shaped spring 231 is inserted into the T-shaped slot 63 of the base connection tube 60, so that the base connection tube 60 and the outer tube 230 are in a connected state. At this time, the free end of the elastic sheet 62 on the base connecting tube 60 is located in the annular groove 411 of the push rod 40, so that the forceps arm 11 and the clamping arm 12 are folded on the surface of the push rod 40. At this time, the connection state of the pushing shaft and the valve clip 100 is shown in fig. 21 and 22.

The second step is that: the valve clip 100 attached thereto is advanced from the left atrium, through the mitral valve, and to the left ventricle by the pusher shaft.

The third step: moving the liner 220 axially distally causes the liner 220 to lift the free end of the spring 62 on the base connector 60, causing the free end of the spring 62 to disengage from the groove 411. At this time, the push rod 40 can move axially in the base connection tube 60, thereby pushing the forceps arm 11 to open and close relative to the push rod 40 and extending and contracting the extension arm 20.

The fourth step: the mandrel 210 is moved proximally by operating the handle, which causes the push rod 40 connected to the mandrel 210 to move in a proximal direction, thereby driving the jawarms 11 to expand relative to the push rod 40 and extending the extension arms 20 from the jawarms 11.

The fifth step: the valve binder 100 is oriented and the relative position of each of the forceps arms 11 to the anterior leaflet 1a and the posterior leaflet 1b is observed by means of X-ray or the like so that the forceps arms 11 are perpendicular to the apposition line of the mitral valve.

And a sixth step: the entire modulated valve binder 100 is withdrawn proximally, causing the

arms

11 and 20 to hold the leaflets on the ventricular side.

The seventh step: the clamp arms 12 are released so that the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve are clamped between the pair of clamp arms 11 and the clamp arms 12, respectively, thereby grasping the leaflets.

Eighth step: moving the mandrel 210 to the far end, wherein the mandrel 210 drives the push rod 40 to move to the far end, so as to drive the jawarms 11 to fold, and enable the extension arm 20 to be retracted into the limiting member 14, i.e. the tail end of the extension arm 20 retracts;

the ninth step: the outer tube 230 is fixed and the liner tube 220 is withdrawn proximally for a certain distance, and the free end of the spring 62 of the base connector 60 is engaged into the annular groove 411 of the push rod 40 to keep the clamp arms 11 closed. The rotation of the spindle 210 is controlled by operating the handle, so that the threads between the spindle 210 and the push rod 40 are unlocked. Liner 220 and mandrel 210 are withdrawn proximally until T-shaped tabs 231 of outer tube 230 are unlocked from T-shaped slots 63 of base connector tube 60. At this point, the valve clip 100 is completely detached from the push shaft. The pushing shaft is withdrawn from the patient, and the valve clamping device 100 is left in the patient, so that the valve leaflet edge-to-edge repair of the mitral valve is completed.

The valve clamping system can be operated in vitro to clamp the valve clamping device with the valve leaflets, so that the problem of mitral regurgitation is reduced or avoided. In addition, the valve clamping device can easily capture the valve leaflets, so that the difficulty of the mitral valve regurgitation operation performed by the valve clamping system is greatly reduced, and the operation time is reduced.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. A graspable valve binder, comprising:

a push rod;

the clamp arms comprise fixed ends and free ends, the fixed ends are connected with the push rods, and the push rods axially move to drive the clamp arms to open and close relative to the push rods by taking the fixed ends as rotating centers;

and the extension arm extends or retracts along the axial direction of the forceps arms, and when the extension arm extends along the fixed end of the forceps arms to the direction of the free end, the tail end of the extension arm exceeds the free end of the forceps arms.

2. The graspable valve clip of claim 1 wherein the extension or retraction of the extension arms is synchronized with the opening or closing of the forceps arms relative to the push rod.

3. The easy-to-clamp valve binder of claim 1 or 2, wherein the distal end of the push rod is provided with a rack, the fixed end of the forceps arm is provided with a gear, and the gear is engaged with the rack.

4. The easy-to-clamp valve binder of claim 1 or 2, wherein the distal end of the push rod is provided with a base, the end of the extension arm away from the distal end is fixed on the base, and the push rod moves axially to drive the extension arm to extend or retract along the forceps arms.

5. The easy-to-clamp valve binder of claim 1, wherein the distal end of the extension arm is provided with a bearing portion, the width of the bearing portion is larger than the diameter of the extension arm when the distal end of the extension arm exceeds the free end of the clamp arm, and the width direction of the bearing portion is the same as the width direction of the clamp arm.

6. The graspable valve clip of claim 5 wherein the carrier is a plate-like structure.

7. The graspable valve clip of claim 5 wherein the carrier portion is a resilient member having a compressed state and an expanded state, the resilient member having an area greater in the expanded state than in the compressed state, the resilient member being in the expanded state when the distal ends of the extension arms extend beyond the free ends of the forceps arms.

8. The graspable valve clip of claim 7 wherein the resilient member is a deformable mesh cage.

9. The graspable valve clip of claim 1 wherein the extension arms are movably disposed on the surface or within the interior of the forceps arms.

10. The easy-to-clamp valve binder of claim 9, wherein the extension arm is constrained to the surface of the clamp arm by a limiting member, and the limiting member is used to limit the extension direction of the extension arm to a direction from the fixed end to the free end of the clamp arm.

11. The easy-to-clamp valve binder of claim 1 further comprising a fixed base comprising two opposing clamping plates, the push rod being positioned between and movable relative to the clamping plates, the fixed ends of the clamp arms being positioned between and rotationally coupled to the clamping plates.

12. The easy-to-clamp valve binder of claim 11, further comprising a base connector that is sleeved outside the push rod and fixed to the fixed base.

13. The easy-to-clamp valve binder of claim 12 wherein the distal ring of the push rod has a circular groove, the base connecting tube has a spring plate, and when the forceps arms are in the closed position, one end of the spring plate is engaged in the circular groove.

14. The graspable valve binder of claim 1 further comprising a grasping member positioned between the arms and the push rod, the grasping member opening and closing relative to the arms to cooperate with the arms to grasp a leaflet.

15. The pinch-resistant valve clip of claim 14 wherein said pinch member is at least partially made of an elastic material.

16. The graspable valve grasper of claim 14 further comprising a fixed base, the holder including at least two grasping arms, each of the grasping arms including a free end and a fixed end disposed opposite each other, the fixed ends of the grasping arms being fixed to the fixed base.

17. The graspable valve clip of claim 16 wherein the grasping arm includes a grasping face opposite the forceps arm, the grasping face having a grasping enhancement.

18. The easy-to-clamp valve binder of claim 17 wherein the clamp arm includes a first surface facing the push rod and a second surface opposite the first surface, the first surface having a recess therein facing the second surface, the clamp reinforcement member being positioned within the recess when the clamp arm is clamped to the clamp arm.

19. The easy-to-clamp valve binder of claim 18, wherein the width of the clamp arms is greater than the width of the clamp arms.

20. The easy-to-clamp valve binder of claim 18 wherein the clamp arms and/or clamp arms are provided with a plurality of spaced apart openings.

21. A valve clamping system, comprising a pushing device and the easily-clamped valve clamp of any one of claims 1-20, wherein the pushing device comprises an operating handle and a pushing shaft with a certain axial length, the proximal end of the pushing shaft is connected with the operating handle, and the distal end of the pushing shaft is detachably connected with the valve clamp.

22. The valve clamping system of claim 21, wherein the pusher shaft comprises a mandrel, a liner tube, and an outer tube movably coaxially nested together, the liner tube being positioned between the mandrel and the outer tube; the mandrel is detachably connected with the push rod and used for pushing the push rod to move along the axial direction.