CN112189849A - 一种降尿酸组合物及其制备方法 - Google Patents
一种降尿酸组合物及其制备方法 Download PDFInfo
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- CN112189849A CN112189849A CN202011172735.4A CN202011172735A CN112189849A CN 112189849 A CN112189849 A CN 112189849A CN 202011172735 A CN202011172735 A CN 202011172735A CN 112189849 A CN112189849 A CN 112189849A
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- uric acid
- dihydromyricetin
- theanine
- resveratrol
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- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 239000000203 mixture Substances 0.000 title claims abstract description 39
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 229940116269 uric acid Drugs 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 claims abstract description 42
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 claims abstract description 42
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 claims abstract description 21
- IPMYMEWFZKHGAX-UHFFFAOYSA-N Isotheaflavin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C(C1=C2)=CC(O)=C(O)C1=C(O)C(=O)C=C2C1C(O)CC2=C(O)C=C(O)C=C2O1 IPMYMEWFZKHGAX-UHFFFAOYSA-N 0.000 claims abstract description 21
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims abstract description 21
- UXRMWRBWCAGDQB-UHFFFAOYSA-N Theaflavin Natural products C1=CC(C2C(CC3=C(O)C=C(O)C=C3O2)O)=C(O)C(=O)C2=C1C(C1OC3=CC(O)=CC(O)=C3CC1O)=CC(O)=C2O UXRMWRBWCAGDQB-UHFFFAOYSA-N 0.000 claims abstract description 21
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- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 claims abstract description 21
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 claims abstract description 21
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 claims abstract description 21
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- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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Abstract
本发明提供了一种降尿酸组合物及其制备方法,涉及保健食品领域,其主要功能性成分是设定配比的茶黄素、白藜芦醇、二氢杨梅素、茶氨酸以及虫草素,该组合物主要通过抑制黄嘌呤氧化酶活性、调节相关阴离子转运体mRNA与蛋白表达水平和促进尿酸***,起到降低尿酸和抗痛风的作用;同时能够减轻IL‑1β刺激后的软骨细胞的基质降解以及降低炎症因子的表达,从而缓解骨关节炎的症状并缓解骨关节疼痛,该降尿酸的组合物具有功效显著、降尿酸明显、安全性好以及服用方便的优点,具有良好的开发应用前景。
Description
技术领域
本发明涉及保健食品领域,尤其涉及一种降尿酸组合物及其制备方法。
背景技术
痛风是一种由于嘌呤生物合成代谢增加、尿酸产生过多或因尿酸***不良而致血中尿酸升高、尿酸盐结晶沉积,从而在关节滑膜、滑囊、软骨及其他组织中引起的反复发作性炎性疾病,是成人最常见的关节炎类型之一。临床对痛风药物治疗以控制病症急性发作、纠正高尿酸与预防关节炎复发和尿酸盐沉积、保护肾脏功能等为主要目标。
目前,降尿酸的化学药物大都容易引发毒副作用,如抑制尿酸生成的药物别嘌呤醇不良反应发生率高,约2%的患者会发生过敏反应,有时可能是严重且致命的,死亡率约为20%;促进尿酸***的药物尿酸酶类药物易诱发急性痛风,约4.5%的患者会产生超敏反应,同时患者经常会产生该类药物抗体,降低疗效。
发明内容
本发明所要解决的技术问题是克服现有技术中存在的不足,提供一种降尿酸组合物及其制备方法。
本发明是通过以下技术方案予以实现:一种降尿酸组合物,包括茶黄素、白藜芦醇、二氢杨梅素、茶氨酸以及虫草素。
根据上述技术方案,优选地,按照重量份数比,包括茶黄素50-70份、白藜芦醇55-75份、二氢杨梅素50-70份、茶氨酸55-70份、虫草素50-65 份。
根据上述技术方案,优选地,还包括辅料组分110-140份、甜味剂 110-140份以及助流剂10-20份。
根据上述技术方案,优选地,按照重量份数比,包括茶黄素50份、白藜芦醇55份、二氢杨梅素50份、茶氨酸55份、虫草素50份、辅料组分120份、甜味剂110份以及助流剂10份。
根据上述技术方案,优选地,按照重量份数比,包括茶黄素60份、白藜芦醇60份、二氢杨梅素60份、茶氨酸60份、虫草素60份、辅料组分130份、甜味剂125份以及助流剂15份。
根据上述技术方案,优选地,按照重量份数比,包括茶黄素70份、白藜芦醇70份、二氢杨梅素70份、茶氨酸65份、虫草素60份、辅料组分135份、甜味剂120份以及助流剂20份。
根据上述技术方案,优选地,所述辅料组分是麦芽糊精。
根据上述技术方案,优选地,所述甜味剂是蔗糖。
根据上述技术方案,优选地,所述助流剂是硬脂酸镁。
一种降尿酸组合物的制备方法,用于制备降尿酸组合物,包括以下步骤:
(1)按照重量份数比,称取茶黄素、白藜芦醇、二氢杨梅素、茶氨酸、虫草素、辅料组分、甜味剂以及助流剂;
(2)充分混合均匀,制成降尿酸的组合物的片剂、胶囊或颗粒。
本发明的有益效果是:本发明提供了一种降尿酸组合物,进而实现预防和/或治疗高尿酸血症/痛风;该组合物的主要组分为茶黄素、白藜芦醇、二氢杨梅素、茶氨酸、虫草素,该组合物主要通过抑制黄嘌呤氧化酶活性、调节相关阴离子转运体mRNA与蛋白表达水平和促进尿酸***,起到降低尿酸和抗痛风的作用;同时减轻IL-1β刺激后的软骨细胞的基质降解以及降低炎症因子的表达,从而缓解骨关节炎的症状并缓解骨关节疼痛,具有良好的开发应用前景。
具体实施方式
下面将对发明的技术方案进行清楚、完整地描述,显然,所描述的实施例是发明一部分实施例,而不是全部的实施例。基于发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于发明保护的范围。
本发明提供了一种降尿酸组合物,包括茶黄素、白藜芦醇、二氢杨梅素、茶氨酸以及虫草素。
进一步的,包括茶黄素50-70份、白藜芦醇55-75份、二氢杨梅素50-70 份、茶氨酸55-70份、虫草素50-65份、辅料组分110-140份、甜味剂 110-140份以及助流剂10-20份,其中辅料组分优选为麦芽糊精,甜味剂优选为蔗糖,助流剂优选为硬脂酸镁。
实施例1
根据上述技术方案,优选地,按照重量份数比,包括茶黄素50份、白藜芦醇55份、二氢杨梅素50份、茶氨酸55份、虫草素50份、麦芽糊精120份、蔗糖110份以及硬脂酸镁10份。
实施例2
根据上述技术方案,优选地,按照重量份数比,包括茶黄素60份、白藜芦醇60份、二氢杨梅素60份、茶氨酸60份、虫草素60份、麦芽糊精130份、蔗糖125份以及硬脂酸镁15份。
实施例3
根据上述技术方案,优选地,按照重量份数比,包括茶黄素70份、白藜芦醇70份、二氢杨梅素70份、茶氨酸65份、虫草素60份、麦芽糊精135份、蔗糖120份以及硬脂酸镁20份。
用于制备降尿酸的组合物的制备方法,包括以下步骤:
(1)按照重量份数比,称取茶黄素、白藜芦醇、二氢杨梅素、茶氨酸、虫草素、辅料组分、甜味剂以及助流剂;
(2)充分混合均匀,制成降尿酸的组合物的片剂、胶囊或颗粒。
片剂:将上述经过效果例验证的优选配方组合(实施例1),充分搅拌均匀,压片,采用压片机将上述成分在环境相对湿度60%以下的环境中进行压片成型以制得成品;包装,将包装袋或包装盒灭菌后进行包装封存。
胶囊:将上述经过效果例验证的优选配方组合(实施例1),充分搅拌均匀,倒入胶囊填充模具中,灌装胶囊,抛光,分装,制得胶囊。
颗粒:将上述经过效果例验证的优选配方组合(实施例1),充分搅拌均匀,使用浓度为50%(V/V)的乙醇作为粘合剂,制成软材,将上述软材制成颗粒,50℃沸腾干燥约40min,控制颗粒水分为5%,然后整粒,分装,制得颗粒剂。
动物实验
采用实施例3中的配方制成实验药,进行动物实验:
选择健康雄性Sprague Dawley大鼠50只,按6.5g/kg灌胃,每日两次,持续30天,未出现毒副反应;
临床资料
1、病例选择收治门诊患者100例,患者年龄在30-70岁,血尿酸(UA) 高于7.0mg/dl,临床表现:经常夜晚出现突然性的关节疼,发病急,关节部位出现严重的疼痛、水肿、红肿和炎症,疼痛感慢慢减轻直至消失,持续几天或几周不等。
2、治疗方法
服用本发明实施例制备的组合物,每次服用1剂,每天早、晚各服1 次,20天为一个疗程,连续服用3个疗程;服药期间,限制高嘌呤,高蛋白食物;忌食豆制品、菠菜、卤菜、味精、酒、醋、动物内脏、海鲜、辛辣刺激等。
3、疗效评定
结果显效:痛风性关节炎消除,身体恢复正常,观察半年后无复发;
好转:痛风性关节炎症状明显好转,身体素质明显恢复;
无效:症状无改善。
4、治疗结果
用本发明的组合物改善痛风性关节炎患者100例,结果显效72例,好转23例,无效5例,总有效率为95.0%,服药过程未观察到过敏及其它不良反应。
综上,本发明的降尿酸的组合物具有功效显著,降尿酸明显,安全性好,服用方便的优点。
本发明的有益效果是:本发明提供了一种降尿酸组合物,进而实现预防和/或治疗高尿酸血症/痛风;该组合物的主要组分为茶黄素、白藜芦醇、二氢杨梅素、茶氨酸、虫草素,该组合物主要通过抑制黄嘌呤氧化酶活性、调节相关阴离子转运体mRNA与蛋白表达水平和促进尿酸***,起到降低尿酸和抗痛风的作用;同时减轻IL-1β刺激后的软骨细胞的基质降解以及降低炎症因子的表达,从而缓解骨关节炎的症状并缓解骨关节疼痛,具有良好的开发应用前景。
最后应说明的是:以上各实施例仅用以说明发明的技术方案,而非对其限制;尽管参照前述各实施例对发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分或者全部技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离发明各实施例技术方案的范围。
Claims (10)
1.一种降尿酸组合物,其特征在于,包括茶黄素、白藜芦醇、二氢杨梅素、茶氨酸以及虫草素。
2.根据权利要求1所述的一种降尿酸组合物,其特征在于,按照重量份数比,包括茶黄素50-70份、白藜芦醇55-75份、二氢杨梅素50-70份、茶氨酸55-70份、虫草素50-65份。
3.根据权利要求2所述的一种降尿酸组合物,其特征在于,还包括辅料组分110-140份、甜味剂110-140份以及助流剂10-20份。
4.根据权利要求3所述的一种降尿酸组合物,其特征在于,按照重量份数比,包括茶黄素50份、白藜芦醇55份、二氢杨梅素50份、茶氨酸55份、虫草素50份、辅料组分120份、甜味剂110份以及助流剂10份。
5.根据权利要求3所述的一种降尿酸组合物,其特征在于,按照重量份数比,包括茶黄素60份、白藜芦醇60份、二氢杨梅素60份、茶氨酸60份、虫草素60份、辅料组分130份、甜味剂125份以及助流剂15份。
6.根据权利要求3所述的一种降尿酸组合物,其特征在于,按照重量份数比,包括茶黄素70份、白藜芦醇70份、二氢杨梅素70份、茶氨酸65份、虫草素60份、辅料组分135份、甜味剂120份以及助流剂20份。
7.根据权利要求4-6中任意一项所述的一种降尿酸组合物,其特征在于,所述辅料组分是麦芽糊精。
8.根据权利要求7所述的一种降尿酸组合物,其特征在于,所述甜味剂是蔗糖。
9.根据权利要求8所述的一种降尿酸组合物,其特征在于,所述助流剂是硬脂酸镁。
10.一种降尿酸组合物的制备方法,用于制备权利要求1-6中任意一项所述的降尿酸组合物,其特征在于,包括以下步骤:
(1)按照重量份数比,称取茶黄素、白藜芦醇、二氢杨梅素、茶氨酸、虫草素、辅料组分、甜味剂以及助流剂;
(2)充分混合均匀,制成降尿酸的组合物的片剂、胶囊或颗粒。
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