CN112107520A - Acne-removing composition and preparation method and application thereof - Google Patents
Acne-removing composition and preparation method and application thereof Download PDFInfo
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- CN112107520A CN112107520A CN202011142118.XA CN202011142118A CN112107520A CN 112107520 A CN112107520 A CN 112107520A CN 202011142118 A CN202011142118 A CN 202011142118A CN 112107520 A CN112107520 A CN 112107520A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 96
- 206010000496 acne Diseases 0.000 title claims abstract description 96
- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims description 28
- 241001474374 Blennius Species 0.000 claims abstract description 74
- 240000004922 Vigna radiata Species 0.000 claims abstract description 74
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims abstract description 74
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims abstract description 74
- 229940069765 bean extract Drugs 0.000 claims abstract description 46
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000008367 deionised water Substances 0.000 claims abstract description 34
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 34
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims abstract description 32
- 239000003906 humectant Substances 0.000 claims abstract description 22
- 229940108325 retinyl palmitate Drugs 0.000 claims abstract description 16
- 235000019172 retinyl palmitate Nutrition 0.000 claims abstract description 16
- 239000011769 retinyl palmitate Substances 0.000 claims abstract description 16
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims abstract description 15
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses an acne-removing composition which is prepared from the following raw materials: seaweed extract, witch hazel extract, isopropyl myristate, mung bean extract, retinol palmitate, mannose oligomer, hydroxyethyl cellulose, a small molecular humectant and deionized water. According to the invention, the seaweed extract, the witch hazel extract, the mung bean extract, the retinol palmitate and the oligomannose are compounded together, so that the components can play a role in synergy, acne removal, acne mark removal and acne muscle repair can be carried out from multiple aspects, and meanwhile, the antibacterial and bactericidal effects are good; the special mung bean extract and the seaweed extract have good synergistic effect, so that the effects of removing acnes and acne marks and repairing acne muscles can be remarkably improved, the mung bean extract can improve and prevent the problems of skin oil, tarnish and acne, and the seaweed extract can shrink pores and improve acne and acne skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an acne-removing composition as well as a preparation method and application thereof.
Background
Acne, commonly known as whelk, is an inflammatory lesion that occurs in the pilosebaceous glands and their surrounding tissues. The pathogenesis of acne vulgaris is as follows: facial sebum secretion is increased, resulting in hyperkeratosis of hair follicles and sebaceous gland ducts. The hyperkeratotic cells combine with sebum, which deposits on hair follicles to form fatty granules, which are broken down by propionibacterium acnes in the hair follicles to produce free fatty acids, causing inflammation to form acne. From the pathogenesis of acne, propionibacterium acnes is a key factor and an important condition for the final formation of acne, and if certain active ingredients can be added in the formula design of cosmetics to effectively inhibit or kill the propionibacterium acnes, the expected acne removing effect can be achieved.
Most of the cosmetics for treating acne in the market at present contain chemical components such as mercury and tartaric acid, adverse reactions such as skin allergy are easily caused, the skin tissue structure is damaged, the treatment effect is not satisfactory, and a few Chinese herbal medicine cosmetics are non-toxic and non-irritant, but are single in treatment effect, only have the effects of disinfection and sterilization, cannot timely reduce swelling and expel pus and repair marks, and are poor in treatment effect. Therefore, the research on new cosmetics capable of treating acne is of great significance to acne patients.
Disclosure of Invention
The invention provides an acne-removing composition and a preparation method and application thereof.
The invention adopts the following technical scheme for solving the technical problems:
an acne-removing composition is prepared from the following raw materials in parts by weight: 2-6 parts of seaweed extract, 2-6 parts of witch hazel extract, 1-4 parts of isopropyl myristate, 1-4 parts of mung bean extract, 1-4 parts of oligomannose, 0.5-1.5 parts of retinol palmitate, 0.4-1 part of hydroxyethyl cellulose, 8-15 parts of micromolecule humectant and 65-80 parts of deionized water.
The applicant of the invention finds in a large number of researches that by compounding several substances with the acne removing effect, such as seaweed extract, witch hazel extract, mung bean extract, retinol palmitate and mannose oligomer, the ingredients can play a role in synergy, and the acne removing and acne mark removing agent can remove acne, repair acne muscles from multiple aspects and has a good antibacterial and bactericidal effect.
As a most preferable scheme, the acne-removing composition is prepared from the following raw materials in parts by weight: 5 parts of seaweed extract, 4 parts of witch hazel extract, 2 parts of isopropyl myristate, 3 parts of mung bean extract, 1.5 parts of oligomannose, 0.8 part of retinol palmitate, 0.5 part of hydroxyethyl cellulose, 12 parts of small molecule humectant and 71.2 parts of deionized water.
Preferably, the small molecular humectant is two or more of glycerol, propylene glycol, butanediol and pentanediol.
The isopropyl myristate and the micromolecular humectant have strong permeability, are easy to enter into the gaps of the keratinocytes, and can effectively permeate the effective components for removing acnes into the cortex, bring the active components into the cortex and fully play the functions of the effective components.
As a most preferred scheme, the small-molecule humectant is prepared from glycerol, propylene glycol, butanediol, pentanediol, and the weight ratio of 4: 3: 4: 1.
As a preferred scheme, the preparation method of the seaweed extract comprises the following steps: cleaning fresh seaweed, drying, crushing to 50-100 meshes to obtain seaweed powder, adding the seaweed powder and mixed enzyme into deionized water, stirring for 60-100 min in a water bath at 55-65 ℃ at a rotating speed of 60-150 rpm, adding the stirred liquid into absolute ethyl alcohol with the weight of 3-5 times of that of the liquid, carrying out ultrasonic treatment for 25-40 min by 500-800W, filtering, and drying to obtain the seaweed extract.
As a preferred scheme, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.01-0.04: 16-20, wherein the mixed enzyme is prepared from cellulase and pectinase according to a weight ratio of 1: 0.5 to 2.
As a preferred scheme, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 60-100 meshes to obtain mung bean powder, adding the mung bean powder into 40-60% ethanol water solution which is 4-8 times of the weight of the mung bean powder, performing ultrasonic treatment for 20-40 min by 400-600W, filtering, centrifuging, taking supernate, evaporating the supernate to obtain extract, adding the extract into deionized water which is 4-6 times of the weight of the extract to obtain suspension, extracting the suspension with mixed solution, and drying the extract to obtain the mung bean extract.
As a preferable scheme, the weight ratio of the suspension to the mixed solution is 1: 3-6, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 4-10: 1.
The mung bean extract and the seaweed extract have good synergistic effect, and can remarkably improve the effects of removing acnes and acne marks and repairing acne muscles, the mung bean extract contains abundant amino acids, alkaloids and the like, has the effects of relieving and repairing skin, can remove dirt in deep skin pores, and can improve and prevent the problems of skin oil, tarnish and acne, and the seaweed extract can clearly age cutin, precipitate pigment, shrink pores, recover elasticity, improve wrinkles, lift skin, reduce acne bacteria, reduce inflammation and improve acne and acne skin.
The mannose oligomer can stimulate the skin to generate antibacterial peptide, enhance the immunity of the skin, resist microbial infection and further achieve the effect of removing acne.
Hamamelis virginiana extract is an effective skin astringent, helps to shrink pores, and removes excess skin oil to prevent the growth of pox. Furthermore, the hamamelis virginiana extract has natural astringent properties to remove facial acne, bacteria and facial oil, and contains a number of compounds with anti-inflammatory effects, including gallic acid and tannins, which are helpful in treating skin inflammation problems.
The invention also provides a preparation method of the acne-removing composition, which comprises the following steps: dissolving isopropyl myristate with a micromolecular humectant in advance, adding the pre-dissolved component and hydroxyethyl cellulose into deionized water, cooling to 60-80 ℃, uniformly stirring, cooling to 35-45 ℃, adding Hamamelis virginiana extract, mung bean extract, seaweed extract and retinol palmitate, and uniformly stirring to obtain the acne-removing composition.
The invention also provides application of the acne-removing composition in cosmetics.
The invention has the beneficial effects that: (1) the acne-removing composition prepared by the scientific proportioning modulation and preparation process has the effects of removing acne, removing acne marks and repairing acne muscles, can effectively remove acne, whelk in a physiological period and whelk caused by endocrine dyscrasia, can quickly relieve the pain and itching feeling in a whelk-growing period, and does not leave marks after acne removal; (2) according to the invention, the seaweed extract, the witch hazel extract, the mung bean extract, the retinol palmitate and the oligomannose are compounded together, so that the components can play a role in synergy, acne removal, acne mark removal and acne muscle repair can be carried out from multiple aspects, and meanwhile, the antibacterial and bactericidal effects are good; (3) the mung bean extract and the seaweed extract have good synergistic effect, so that the effects of removing acnes and acne marks and repairing acne muscles can be obviously improved, the mung bean extract contains abundant amino acids, alkaloids and the like, has the effects of relieving and repairing skin, can remove dirt in deep skin pores, and can improve and prevent the problems of skin oil, tarnish and acne, and the seaweed extract can clearly age cutin, precipitate pigment, shrink pores, recover elasticity, improve wrinkles, lift and pull the skin, reduce acne bacteria, reduce inflammation and improve acne and acne skin; (4) the isopropyl myristate and the micromolecular humectant have strong permeability, are easy to enter into the gaps of the keratinocytes, and can effectively permeate the effective components for removing acnes into the cortex, bring the active components into the cortex and fully play the functions of the effective components.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The raw materials of the invention are self-made except the seaweed extract and the mung bean extract, and other raw materials are all available on the market.
Example 1
The acne-removing composition is prepared from the following raw materials in parts by weight: 5 parts of seaweed extract, 4 parts of witch hazel extract, 2 parts of isopropyl myristate, 3 parts of mung bean extract, 1.5 parts of oligomannose, 0.8 part of retinol palmitate, 0.5 part of hydroxyethyl cellulose, 12 parts of small molecule humectant and 71.2 parts of deionized water.
In this embodiment, the small molecule humectant is prepared from glycerin, propylene glycol, butylene glycol, and pentylene glycol in a weight ratio of 4: 3: 4: 1.
In this embodiment, the preparation method of the seaweed extract comprises: cleaning fresh seaweed, drying, pulverizing to 80 mesh to obtain seaweed powder, adding seaweed powder and mixed enzyme into deionized water, stirring in 60 deg.C water bath at 100rpm for 80min, adding the stirred liquid into anhydrous ethanol 4 times the weight of the liquid, treating with 600W ultrasound for 35min, filtering, and drying to obtain seaweed extract.
In this embodiment, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.02: 19, the mixed enzyme is prepared from cellulase and pectinase according to the weight ratio of 1: 1 composition of
In this embodiment, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 70 meshes to obtain mung bean powder, adding the mung bean powder into 50% ethanol water solution with the weight 5 times of that of the mung bean powder, carrying out ultrasonic treatment for 30min by 500W, filtering, centrifuging, taking supernatant, evaporating the supernatant to obtain extract, adding the extract into deionized water with the weight 5 times of that of the extract to obtain suspension, extracting the suspension with mixed solution, and drying extract to obtain the mung bean extract.
In this embodiment, the weight ratio of the suspension to the mixed solution is 1: 4, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 9: 1.
The preparation method of the acne-removing composition comprises the following steps: dissolving isopropyl myristate with small molecular humectant in advance, adding the pre-dissolved component and hydroxyethyl cellulose into deionized water, cooling to 75 deg.C, stirring, cooling to 40 deg.C, adding Hamamelis virginiana extract, semen Phaseoli Radiati extract, Sargassum extract and retinol palmitate, and stirring to obtain the composition for removing acne.
Example 2
The acne-removing composition is prepared from the following raw materials in parts by weight: 2 parts of seaweed extract, 2 parts of witch hazel extract, 1 part of isopropyl myristate, 1 part of mung bean extract, 1 part of oligomannose, 0.5 part of retinol palmitate, 0.4 part of hydroxyethyl cellulose, 8 parts of small molecule humectant and 65 parts of deionized water.
In this embodiment, the small molecule humectant is prepared from glycerin, propylene glycol, butylene glycol, and pentylene glycol in a weight ratio of 4: 3: 4: 1.
In this embodiment, the preparation method of the seaweed extract comprises: cleaning fresh seaweed, drying, pulverizing to 80 mesh to obtain seaweed powder, adding seaweed powder and mixed enzyme into deionized water, stirring in 60 deg.C water bath at 100rpm for 80min, adding the stirred liquid into anhydrous ethanol 4 times the weight of the liquid, treating with 600W ultrasound for 35min, filtering, and drying to obtain seaweed extract.
In this embodiment, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.02: 19, the mixed enzyme is prepared from cellulase and pectinase according to the weight ratio of 1: 1.
In this embodiment, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 70 meshes to obtain mung bean powder, adding the mung bean powder into 50% ethanol water solution with the weight 5 times of that of the mung bean powder, carrying out ultrasonic treatment for 30min by 500W, filtering, centrifuging, taking supernatant, evaporating the supernatant to obtain extract, adding the extract into deionized water with the weight 5 times of that of the extract to obtain suspension, extracting the suspension with mixed solution, and drying extract to obtain the mung bean extract.
In this embodiment, the weight ratio of the suspension to the mixed solution is 1: 4, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 9: 1.
The preparation method of the acne-removing composition comprises the following steps: dissolving isopropyl myristate with small molecular humectant in advance, adding the pre-dissolved component and hydroxyethyl cellulose into deionized water, cooling to 75 deg.C, stirring, cooling to 40 deg.C, adding Hamamelis virginiana extract, semen Phaseoli Radiati extract, Sargassum extract and retinol palmitate, and stirring to obtain the composition for removing acne.
Example 3
The acne-removing composition is prepared from the following raw materials in parts by weight: 6 parts of seaweed extract, 6 parts of witch hazel extract, 4 parts of isopropyl myristate, 4 parts of mung bean extract, 4 parts of oligomannose, 1.5 parts of retinol palmitate, 1 part of hydroxyethyl cellulose, 15 parts of small molecule humectant and 80 parts of deionized water.
In this embodiment, the small molecule humectant is prepared from glycerin, propylene glycol, butylene glycol, and pentylene glycol in a weight ratio of 4: 3: 4: 1.
In this embodiment, the preparation method of the seaweed extract comprises: cleaning fresh seaweed, drying, pulverizing to 80 mesh to obtain seaweed powder, adding seaweed powder and mixed enzyme into deionized water, stirring in 60 deg.C water bath at 100rpm for 80min, adding the stirred liquid into anhydrous ethanol 4 times the weight of the liquid, treating with 600W ultrasound for 35min, filtering, and drying to obtain seaweed extract.
In this embodiment, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.02: 19, mixing cellulase and pectinase according to a weight ratio of 1: 1.
In this embodiment, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 70 meshes to obtain mung bean powder, adding the mung bean powder into 50% ethanol water solution with the weight 5 times of that of the mung bean powder, carrying out ultrasonic treatment for 30min by 500W, filtering, centrifuging, taking supernatant, evaporating the supernatant to obtain extract, adding the extract into deionized water with the weight 5 times of that of the extract to obtain suspension, extracting the suspension with mixed solution, and drying extract to obtain the mung bean extract.
In this embodiment, the weight ratio of the suspension to the mixed solution is 1: 4, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 9: 1.
The preparation method of the acne-removing composition comprises the following steps: dissolving isopropyl myristate with small molecular humectant in advance, adding the pre-dissolved component and hydroxyethyl cellulose into deionized water, cooling to 75 deg.C, stirring, cooling to 40 deg.C, adding Hamamelis virginiana extract, semen Phaseoli Radiati extract, Sargassum extract and retinol palmitate, and stirring to obtain the composition for removing acne.
Example 4
Example 4 differs from example 1 in the preparation parameters of the seaweed extract and mung bean extract, which are different, and they are the same.
In this embodiment, the preparation method of the seaweed extract comprises: cleaning fresh seaweed, drying, pulverizing to 50 mesh to obtain seaweed powder, adding seaweed powder and mixed enzyme into deionized water, stirring in 55 deg.C water bath at 60rpm for 80min, adding the stirred liquid into 3 times of anhydrous ethanol, treating with 500W ultrasound for 25min, filtering, and drying to obtain seaweed extract.
In this embodiment, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.01: 16, the mixed enzyme is prepared from cellulase and pectinase according to the weight ratio of 1: 0.5.
In this embodiment, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 60 meshes to obtain mung bean powder, adding the mung bean powder into 40% ethanol water solution with the weight 4 times of that of the mung bean powder, carrying out ultrasonic treatment for 30min by 400W, filtering, centrifuging, taking supernatant, evaporating the supernatant to obtain extract, adding the extract into deionized water with the weight 4 times of that of the extract to obtain suspension, extracting the suspension with mixed solution, and drying extract to obtain the mung bean extract.
In this embodiment, the weight ratio of the suspension to the mixed solution is 1: 3, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 4: 1.
Example 5
Example 5 example 1 differs in the preparation parameters of the seaweed extract and the mung bean extract, but they are otherwise identical.
In this embodiment, the preparation method of the seaweed extract comprises: cleaning fresh seaweed, drying, pulverizing to 100 mesh to obtain seaweed powder, adding seaweed powder and mixed enzyme into deionized water, stirring at 150rpm in 65 deg.C water bath for 70min, adding the stirred liquid into 5 times of anhydrous ethanol, treating with 800W ultrasound for 40min, filtering, and drying to obtain seaweed extract.
In this embodiment, the weight ratio of the seaweed meal, the mixed enzyme and the deionized water is 1: 0.04: 20, the mixed enzyme is prepared from cellulase and pectinase according to the weight ratio of 1: 0.5 to 2.
In this embodiment, the preparation method of the mung bean extract comprises the following steps: grinding mung beans to 100 meshes to obtain mung bean powder, adding the mung bean powder into 60% ethanol water solution which is 8 times of the weight of the mung bean powder, carrying out ultrasonic treatment for 30min by 600W, filtering, centrifuging, taking supernatant, evaporating the supernatant to obtain extract, adding the extract into deionized water which is 6 times of the weight of the extract to obtain suspension, extracting the suspension with mixed solution, and drying extract to obtain the mung bean extract.
In this embodiment, the weight ratio of the suspension to the mixed solution is 1: 6, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 10: 1.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain seaweed extract, and the other things are the same.
Comparative example 2
Comparative example 2 differs from example 1 in that comparative example 2 does not contain mung bean extract, and the other things are the same.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain mung bean extract, seaweed extract, and the others are the same.
Comparative example 4
Comparative example 4 is different from example 1 in that the seaweed extract and the mung bean extract described in comparative example 4 are commercially available, and the others are the same.
In this comparative example, the seaweed extract of example 1 was replaced with an enzymatically hydrolyzed seaweed spray dried powder purchased from the bio-technology limited of the Kehseng sea in Qingdao.
In this comparative example, the mung bean extract of example 1 was replaced with a mung bean extract purchased from kaifen biosciences, Guangzhou.
To further demonstrate the effect of the present invention, the following test methods were provided:
1. the test method comprises the following steps: the test method briefly describes: propionibacterium acnes bacteriostasis test (cup dish method)
Preparing double-layer plate (the lower layer is 10-15 ml of culture medium, the upper layer is 5ml of culture medium containing propionibacterium acnes) containing propionibacterium acnes (ATCC11827), and the bacterial content of the plate is 104-105And (3) cooling the plates by using the CFU/plate, and vertically placing 2 Oxford cups on the surface of each plate, wherein the distance between every two Oxford cups is not less than 24mm, and the distance between the centers of the Oxford cups and the edge of the plate is not less than 15 mm. 200ul of the acne-removing composition described in examples 1 to 5 and comparative examples 1 to 4 to be tested was added into an oxford cup, the oxford cup was cultured under anaerobic conditions at 36 ± 1 ℃ for 24 hours, and then the diameter of the zone of inhibition was measured with a ruler (the result was an average of three parallel samples). The results are shown in Table 1. The test groups are classified according to the grade of antibacterial drug sensitivity: the diameter of the antibacterial ring is more than 20mm, the antibacterial ring is efficient, 15-20 mm is medium-efficient, 10-15mm is low-efficient, and less than 10mm is ineffective.
TABLE 1 bacteriostatic diameter test results
As can be seen from table 1, the acne removing composition of the present invention has a good effect of inhibiting propionibacterium acnes, and thus has a good acne removing efficacy.
As can be seen from comparison of examples 1-3, the proportions of different raw materials can affect the acne removing effect (i.e., the effect of inhibiting propionibacterium acnes), wherein example 1 is the optimal proportion; the comparative examples 1, 4 and 5 show that different preparation parameters of the seaweed extract and the mung bean extract can influence the acne removing effect, wherein the example 1 is the optimal preparation parameter, and the comparative example 1 and the comparative examples 1 to 4 show that the acne removing composition has a good acne removing effect, wherein the seaweed extract and the mung bean extract can remarkably influence the acne removing effect, and the seaweed extract and the mung bean extract have a good synergistic effect and have a better effect than the commercially available seaweed extract and mung bean extract.
2. And (5) evaluating the product effect.
And (3) testing a sample: examples 1-5 acne removing compositions.
The test population: 30 women between 20-30 years old; 20 men.
Skin condition: the face has obvious acne and pox, has no allergic history of dermatosis, and meets the voluntary selection standard of a subject.
Grouping: divided into 5 groups of 5 persons each, female 3 persons, male 2 persons.
The test method comprises the following steps: applying appropriate amount of test sample on cleaned affected part, 2 times per day, 1 time each in the morning and evening, and trying for 2 weeks; subjects maintained good working and resting time and eating habits during the trial period. After 2 weeks, the feedback of the subjects was counted, and the specific results are shown in Table 2.
TABLE 2 evaluation of the product
As can be seen from table 2, the acne removing composition of the present invention can effectively remove acne, remove acne marks, and repair acne muscles.
Compared with the examples 1-3, the proportion of different raw materials can influence the effects of removing acne, removing acne marks and repairing acne muscles, wherein the example 1 is the optimal proportion; comparing examples 1, 4 and 5, it can be seen that different preparation parameters of the seaweed extract and the mung bean extract can influence the effects of removing acne, acne marks and repairing acne muscles, wherein example 1 is the best preparation parameter.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The acne-removing composition is characterized by being prepared from the following raw materials in parts by weight: 2-6 parts of seaweed extract, 2-6 parts of witch hazel extract, 1-4 parts of isopropyl myristate, 1-4 parts of mung bean extract, 1-4 parts of oligomannose, 0.5-1.5 parts of retinol palmitate, 0.4-1 part of hydroxyethyl cellulose, 8-15 parts of micromolecule humectant and 65-80 parts of deionized water.
2. The acne treatment composition according to claim 1, wherein the acne treatment composition is prepared from the following raw materials in parts by weight: 5 parts of seaweed extract, 4 parts of witch hazel extract, 2 parts of isopropyl myristate, 3 parts of mung bean extract, 1.5 parts of oligomannose, 0.8 part of retinol palmitate, 0.5 part of hydroxyethyl cellulose, 12 parts of small molecule humectant and 71.2 parts of deionized water.
3. The acne removal composition according to claim 1, wherein the small molecule humectant is two or more of glycerin, propylene glycol, butylene glycol and pentylene glycol.
4. The acne removal composition according to claim 1, wherein the small molecule humectant is prepared from glycerin, propylene glycol, butylene glycol, and pentylene glycol in a weight ratio of 4: 3: 4: 1.
5. The acne-removing composition according to claim 1, wherein the seaweed extract is prepared by a method comprising: cleaning fresh seaweed, drying, crushing to 50-100 meshes to obtain seaweed powder, adding the seaweed powder and mixed enzyme into deionized water, stirring for 60-100 min in a water bath at 55-65 ℃ at a rotating speed of 60-150 rpm, adding the stirred liquid into absolute ethyl alcohol with the weight of 3-5 times of that of the liquid, carrying out ultrasonic treatment for 25-40 min by 500-800W, filtering, and drying to obtain the seaweed extract.
6. The acne-removing composition according to claim 5, wherein the weight ratio of the seaweed powder, the mixed enzyme and the deionized water is 1: 0.01-0.04: 16-20, wherein the mixed enzyme is prepared from cellulase and pectinase according to a weight ratio of 1: 0.5 to 2.
7. The acne treatment composition according to claim 1, wherein the mung bean extract is prepared by a method comprising: grinding mung beans to 60-100 meshes to obtain mung bean powder, adding the mung bean powder into 40-60% ethanol water solution which is 4-8 times of the weight of the mung bean powder, performing ultrasonic treatment for 20-40 min by 400-600W, filtering, centrifuging, taking supernate, evaporating the supernate to obtain extract, adding the extract into deionized water which is 4-6 times of the weight of the extract to obtain suspension, extracting the suspension with mixed solution, and drying the extract to obtain the mung bean extract.
8. The acne removal composition according to claim 7, wherein the weight ratio of the suspension to the mixed solution is 1: 3-6, mixing the mixed solution with ethyl acetate and chloroform according to a weight ratio of 4-10: 1.
9. The preparation method of the acne-removing composition according to any one of claims 1 to 8, which is characterized by comprising the following steps: dissolving isopropyl myristate with a micromolecular humectant in advance, adding the pre-dissolved component and hydroxyethyl cellulose into deionized water, cooling to 60-80 ℃, uniformly stirring, cooling to 35-45 ℃, adding Hamamelis virginiana extract, mung bean extract, seaweed extract and retinol palmitate, and uniformly stirring to obtain the acne-removing composition.
10. Use of the acne-removing composition prepared according to claim 9 in cosmetics.
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