CN112089636A - Deodorizing composition and preparation method and application thereof - Google Patents
Deodorizing composition and preparation method and application thereof Download PDFInfo
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- CN112089636A CN112089636A CN202011110046.0A CN202011110046A CN112089636A CN 112089636 A CN112089636 A CN 112089636A CN 202011110046 A CN202011110046 A CN 202011110046A CN 112089636 A CN112089636 A CN 112089636A
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- deodorant composition
- deodorant
- composition
- mass
- humectant
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- 239000000203 mixture Substances 0.000 title claims abstract description 90
- 230000001877 deodorizing effect Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000002781 deodorant agent Substances 0.000 claims abstract description 59
- 239000002994 raw material Substances 0.000 claims abstract description 21
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960000281 trometamol Drugs 0.000 claims abstract description 19
- 239000003906 humectant Substances 0.000 claims abstract description 10
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 9
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 8
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 8
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 21
- 238000003756 stirring Methods 0.000 claims description 11
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 9
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 9
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 229960004698 dichlorobenzyl alcohol Drugs 0.000 claims description 9
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims description 9
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 8
- 238000004332 deodorization Methods 0.000 claims description 7
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 229940094952 green tea extract Drugs 0.000 claims description 5
- 235000020688 green tea extract Nutrition 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- 229940081510 piroctone olamine Drugs 0.000 claims description 4
- 229940057070 sugarcane extract Drugs 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229960003237 betaine Drugs 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- 229940027779 persimmon extract Drugs 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims description 2
- 150000003077 polyols Chemical class 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 239000001069 triethyl citrate Substances 0.000 claims description 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 2
- 235000013769 triethyl citrate Nutrition 0.000 claims description 2
- DBHODFSFBXJZNY-UHFFFAOYSA-N 2,4-dichlorobenzyl alcohol Chemical compound OCC1=CC=C(Cl)C=C1Cl DBHODFSFBXJZNY-UHFFFAOYSA-N 0.000 claims 3
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims 1
- 239000005770 Eugenol Substances 0.000 claims 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229960001422 aluminium chlorohydrate Drugs 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 229960002217 eugenol Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 208000035985 Body Odor Diseases 0.000 abstract description 8
- 206010040904 Skin odour abnormal Diseases 0.000 abstract description 8
- 150000002632 lipids Chemical class 0.000 abstract description 6
- 230000028327 secretion Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- 210000000106 sweat gland Anatomy 0.000 abstract description 6
- 230000009965 odorless effect Effects 0.000 abstract description 5
- 230000009967 tasteless effect Effects 0.000 abstract description 5
- 231100000817 safety factor Toxicity 0.000 abstract description 4
- 230000002708 enhancing effect Effects 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 7
- TZZGHGKTHXIOMN-UHFFFAOYSA-N 3-trimethoxysilyl-n-(3-trimethoxysilylpropyl)propan-1-amine Chemical compound CO[Si](OC)(OC)CCCNCCC[Si](OC)(OC)OC TZZGHGKTHXIOMN-UHFFFAOYSA-N 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 6
- 230000001166 anti-perspirative effect Effects 0.000 description 5
- 239000003213 antiperspirant Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 4
- BSAIUMLZVGUGKX-UHFFFAOYSA-N 2-Nonenal Natural products CCCCCCC=CC=O BSAIUMLZVGUGKX-UHFFFAOYSA-N 0.000 description 4
- BSAIUMLZVGUGKX-FPLPWBNLSA-N 2-nonenal Chemical compound CCCCCC\C=C/C=O BSAIUMLZVGUGKX-FPLPWBNLSA-N 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 4
- 235000000484 citronellol Nutrition 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- MCVVUJPXSBQTRZ-ONEGZZNKSA-N methyl (e)-but-2-enoate Chemical compound COC(=O)\C=C\C MCVVUJPXSBQTRZ-ONEGZZNKSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- 229940074410 trehalose Drugs 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- OXDRRSIWCCBLOE-UHFFFAOYSA-N 3-methylbutanoic acid Chemical compound CC(C)CC(O)=O.CC(C)CC(O)=O OXDRRSIWCCBLOE-UHFFFAOYSA-N 0.000 description 1
- HFVMLYAGWXSTQI-QYXZOKGRSA-N 5alpha-androst-16-en-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CC[C@H]21 HFVMLYAGWXSTQI-QYXZOKGRSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- ROCGEVCZBBJDPU-UHFFFAOYSA-N C(C=CCCCCCC)=O.C(C=CCCCCCC)=O Chemical compound C(C=CCCCCCC)=O.C(C=CCCCCCC)=O ROCGEVCZBBJDPU-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000192041 Micrococcus Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 150000001414 amino alcohols Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 210000001099 axilla Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- IMZFSONSIHHFAR-UHFFFAOYSA-L dichloroaluminum;hydrate Chemical compound O.Cl[Al]Cl IMZFSONSIHHFAR-UHFFFAOYSA-L 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- JYDNQSLNPKOEII-CFYXSCKTSA-N hexadec-9-enoic acid;(z)-hexadec-9-enoic acid Chemical compound CCCCCCC=CCCCCCCCC(O)=O.CCCCCC\C=C/CCCCCCCC(O)=O JYDNQSLNPKOEII-CFYXSCKTSA-N 0.000 description 1
- 208000002557 hidradenitis Diseases 0.000 description 1
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
- 150000002466 imines Chemical class 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 150000002917 oxazolidines Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 229960003912 probucol Drugs 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a deodorizing composition and a preparation method and application thereof, belonging to the field of daily chemical products, wherein the deodorizing composition is prepared from the following raw materials in parts by mass: 0.1-10% of tromethamine, 0.05-10% of antibacterial agent, 0.1-5% of aromatic, 0.5-10% of humectant, 0.05-0.5% of antioxidant, 0.1-6% of pH regulator and the balance of solvent. The deodorant composition of the invention is added with tromethamine which can react with lipid oxide or sweat gland secretion components as a neutralizer to change the components into odorless and tasteless safety factors, thereby enhancing the deodorant effect and fundamentally solving the problem of body odor.
Description
Technical Field
The invention belongs to the field of daily chemical articles, and particularly relates to a deodorizing composition.
Background
The related data show that the density of residual bacteria in human axillary skin is as high as 106 bacteria/cm2In the axilla, there are generally two types of flora: the corynebacteria and micrococcus (e.g., staphylococcus epidermidis) are well adapted to the higher pH and higher humidity ecological environment, and prefer to reproduce in the underarm skin, the water required for reproduction is supplied by eccrine sweat gland secretion, and the components secreted by the apocrine sweat gland, such as isovaleric acid and androstenone, are considered to be factors causing the underarm odor. Thus, the human body comes outWhen sweating, the armpit not only can breed bacteria, but also can give off peculiar smell.
In addition, elderly people also develop peculiar odor, which is called "old age odor", and the cause of the "old age odor" is attributed to one of unsaturated aldehydes: 2-nonenal. 2-nonenal is obtained by oxidizing 9-hexadecenoic acid (palmitoleic acid) present in sebum or decomposing it by bacteria normally parasitic to human skin, and 2-nonenal is detected in a very low amount in people of low ages such as 20 years old and 30 years old, but the proportion and amount of 2-nonenal detected in people over 40 years old tend to increase, thus causing the emission of bad smell in the elderly.
As can be seen, the formation of body odor or off-taste may be due to the degradation of sweat-secreting bacteria to form malodorous substances, or to cell debris denudation, lipid oxidation, etc., and volatile odorous compounds may also cause malodors. Therefore, some products appear in the market at present to remove or reduce odor, most of the products are perfume and antiperspirant, and the perfume can only cover odor generally and cannot solve the problem of body odor fundamentally; the antiperspirant has the effects of reducing sweat flowing to the skin surface and inhibiting the reproduction of bacteria causing body odor, but the antiperspirant only acts on the skin surface, and the efficacy of the antiperspirant is affected correspondingly due to the metabolism of the horny layer and the stripping of metal salt components, so the deodorization effect is not ideal.
Disclosure of Invention
Based on the above background problems, the present invention aims to provide a deodorant composition, wherein tromethamine is used as a neutralizing agent to react with lipid oxide or sweat gland secretion components to change the lipid oxide or sweat gland secretion components into odorless and tasteless safety factors, so that the problem of body odor is fundamentally solved, and the deodorant effect is good. Another object of the present invention is to provide a process for the preparation and use of the above deodorant composition.
In order to achieve the above object, on one hand, the embodiment of the present invention provides a technical solution:
the deodorization composition comprises the following raw materials in percentage by mass:
0.1-10% of tromethamine, 0.05-10% of antibacterial agent, 0.1-5% of aromatic, 0.5-10% of humectant, 0.05-0.5% of antioxidant, 0.1-6% of pH regulator and the balance of solvent.
The structural formula of tromethamine is shown as formula (I), and the tromethamine is multifunctional amino alcohol, has excellent safety, and can capture aldehyde and fatty acid; common chemicals that produce off-flavors are isovaleric acid (3-methylbutanic acid), 2-nonenal (2-nonenal), propionic acid, and the like.
The reaction of tromethamine with aldehydes can form imines or oxazolidines, the reaction formula is shown in formula (II):
tromethamine can also react with acid to generate ammonium salt, so that the chemical substances generating peculiar smell become odorless and tasteless; and the tromethamine can also effectively react with formaldehyde and hydrogen sulfide to achieve the effects of indoor odor purification and removal of some harmful substances.
In an embodiment, the antibacterial agent is selected from one or more of dichlorobenzyl alcohol, piroctone olamine, chlorhexidine salts, probucol phenol or hydroxyaluminum chloride.
Preferably, the antibacterial agent is a composition formed by dichlorobenzyl alcohol, aluminum chlorohydrate and piroctone olamine salt, and the mass fraction of the dichlorobenzyl alcohol, the mass fraction of the aluminum chlorohydrate and the mass fraction of the piroctone olamine salt in the deodorization composition are respectively 0.01-0.15%, 0.01-9.55% and 0.05-0.3%.
In one embodiment, the humectant is selected from one or more of betaine, polyol, trehalose, hyaluronic acid.
Preferably, the humectant is a composition formed by propylene glycol and trehalose, and the mass fraction of the propylene glycol and the mass fraction of the trehalose in the deodorization composition are respectively 0.5-6% and 0.1-4%.
In one embodiment, the antioxidant is selected from one or more of tocopheryl acetate, butylated hydroxytoluene, sugar cane extract, green tea extract, persimmon extract, VC derivatives.
In one embodiment, the pH adjusting agent is selected from one or more of citric acid, lactic acid, glycolic acid, fruit acid, triethyl citrate.
In one embodiment, the deodorant composition has a pH of 4 to 8.
On the other hand, the embodiment of the invention also provides a preparation method of the deodorant composition, which comprises the steps of mixing the solvent, the tromethamine, the humectant, the antibacterial agent and the antioxidant which are weighed according to the proportion, and stirring until the raw materials are completely dissolved to obtain a mixture; adding the pH regulator weighed according to the proportion into the mixture, regulating the pH to 4-8, finally adding the aromatic weighed according to the proportion, and uniformly stirring.
In addition, the embodiment of the invention also provides the application of the deodorizing composition in deodorizing products, wherein the deodorizing products can be personal care products, household care products, pet products or interior products of vehicles.
Compared with the prior art, the invention has the following effects:
the deodorant composition of the invention is added with tromethamine which can react with lipid oxide or sweat gland secretion components as a neutralizer to change the components into odorless and tasteless safety factors, thereby enhancing the deodorant effect and fundamentally solving the problem of body odor.
Detailed Description
In order to solve the defect of poor deodorization effect of the existing antiperspirant, the invention provides a deodorization composition, which comprises the following raw materials in percentage by mass:
0.1-10% of tromethamine, 0.05-10% of antibacterial agent, 0.1-5% of aromatic, 0.5-10% of humectant, 0.05-0.5% of antioxidant, 0.1-6% of pH regulator and the balance of solvent.
The deodorant composition of the invention is added with tromethamine which can react with lipid oxide or sweat gland secretion components as a neutralizer to change the components into odorless and tasteless safety factors, thereby enhancing the deodorant effect and fundamentally solving the problem of body odor.
It should be noted that the sugarcane extract and the green tea extract used in the examples of the present invention are both available products, the manufacturer is Jiangxi Baizhentang Biotech Co., Ltd, citronellol methylcrotonate is the INCI name of the catalog of used raw materials for cosmetics, and the manufacturer is Qihuaton Co.
The invention will be elucidated by means of specific embodiments.
Example 1
A deodorant composition comprises the raw materials shown in Table 1, wherein the mass unit of each component is kg.
TABLE 1 composition Table for hair care compositions of example 1
The method of preparing the deodorant composition of this example comprises the steps of:
1. adding water, tromethamine, betaine, peach carina phenol and VC sodium phosphate into an emulsifying pot, mixing and stirring until the raw materials are completely dissolved to obtain a mixture;
2. adding citric acid into the mixture, adjusting pH to 4, adding citronellol methylcrotonate, and stirring.
Example 2
A deodorant composition comprises the raw materials shown in Table 2, wherein the mass unit of each component is kg.
Table 2 table of ingredients of deodorant composition in example 2
The method of preparing the deodorant composition of this example comprises the steps of:
1. adding ethanol, tromethamine, dichlorobenzyl alcohol, aluminum chlorohydrate, piroctone olamine salt, propylene glycol, trehalose, mannitol and sugarcane extract into an emulsifying pot, and mixing and stirring until the raw materials are completely dissolved to obtain a mixture;
2. adding lactic acid into the mixture, adjusting the pH value to 8, finally adding essence, and uniformly stirring.
Example 3
A deodorant composition comprises the raw materials shown in Table 3, wherein the mass unit of each component is kg.
Table 3 table of ingredients of deodorant composition in example 3
The method of preparing the deodorant composition of this example comprises the steps of:
1. adding ethanol, tromethamine, piroctone olamine salt, dichlorobenzyl alcohol, trehalose, propylene glycol, tocopherol acetate and green tea extract into an emulsifying pot, mixing and stirring until the raw materials are completely dissolved to obtain a mixture;
2. adding glycolic acid into the mixture, adjusting pH to 6, adding essence and citronellol methylcrotonate, and stirring.
Example 4
A deodorant composition comprises the raw materials shown in Table 4, wherein the mass unit of each component is kg.
Table 4 table of ingredients of deodorant composition in example 4
The preparation method of the deodorant composition in this example was the same as that of example 3.
Example 5
A deodorant composition comprises the raw materials shown in Table 5, wherein the mass unit of each component is kg.
Table 5 table of ingredients of deodorant composition in example 5
The preparation method of the deodorant composition in this example was the same as that of example 3.
Example 6
A deodorant composition comprises the raw materials shown in Table 6, wherein the mass unit of each component is kg.
Table 6 table of ingredients of deodorant composition in example 6
The preparation method of the deodorant composition in this example was the same as that of example 3.
Example 7
A deodorant composition consisting of the raw materials in Table 7, wherein the mass unit of each component is kg.
Table 7 table of ingredients of deodorant composition in example 7
The preparation method of the deodorant composition in this example was the same as that of example 3.
Example 8
A deodorant composition consisting of the raw materials in Table 8, wherein the mass unit of each component is kg.
Table 8 table of ingredients of deodorant composition in example 8
The preparation method of the deodorant composition in this example was the same as that of example 3.
Example 9
A deodorant composition consisting of the raw materials in Table 9, wherein the mass unit of each component is kg.
Table 9 table of ingredients of deodorant composition in example 9
The preparation method of the deodorant composition in this example was the same as that of example 3.
Comparative example
A deodorant composition consisting of the raw materials shown in Table 10, wherein the mass unit of each component is kg.
TABLE 10 ingredient Table of deodorant composition in comparative example
The deodorizing composition of the comparative example is different from that of example 9 in that tromethamine is not contained in the deodorizing composition of the comparative example.
The preparation method of the deodorizing composition of comparative example 1 comprises the steps of:
1. adding ethanol, piroctone olamine salt, dichlorobenzyl alcohol, trehalose, propylene glycol, tocopherol acetate and green tea extract into an emulsifying pot, and mixing and stirring until the raw materials are completely dissolved to obtain a mixture;
2. adding glycolic acid into the mixture, adjusting pH to 6, adding essence and citronellol methylcrotonate, and stirring.
To verify the beneficial effects of the present invention, the following tests were performed:
1. test method
80 test persons with the taste of old people, the ages of which are between 55 and 60 years old, are selected and randomly divided into 8 groups, and 10 persons in each group are respectively numbered A/B/C/D/E/F/G/H/I/G.
The deodorizing compositions prepared in examples 3 to 9 and comparative example were used for deodorizing, and the compositions were applied in the form of a spray, directly sprayed on human skin, and evaluated after 24 hours.
Specifically, the first group employed the deodorant composition of example 3, the second group employed the deodorant composition of example 4, the third group employed the deodorant composition of example 5, the fourth group employed the deodorant composition of example 6, the fifth group employed the deodorant composition of example 7, the sixth group employed the deodorant composition of example 8, the seventh group employed the deodorant composition of example 9, and the eighth group employed the deodorant composition of comparative example.
2. Effect evaluation Table
The usage effect corresponding to the evaluation level is shown in table 11.
TABLE 11 evaluation of effects
3. Test results
The test results are shown in table 12.
TABLE 12 evaluation Table of effects of use
As can be seen from table 12, the deodorizing compositions of the present invention can solve the problem of body odor or emission of offensive odor, and can provide a long-lasting deodorizing effect. Of these, example 9 (group seven) was the most effective and the test personnel showed a long lasting suppression of malodour development after 24h of use with a moderately pleasant fragrance.
It should be noted that, for those skilled in the art, various changes and modifications can be made without departing from the inventive concept of the present invention, and these changes and modifications belong to the protection scope of the present invention.
Claims (10)
1. The deodorization composition is characterized by comprising the following raw materials in percentage by mass:
0.1-10% of tromethamine, 0.05-10% of antibacterial agent, 0.1-5% of aromatic, 0.5-10% of humectant, 0.05-0.5% of antioxidant, 0.1-6% of pH regulator and the balance of solvent.
2. Deodorant composition according to claim 1, wherein the antibacterial agent is selected from one or more of dichlorobenzyl alcohol, piroctone olamine, chlorhexidine salts, eugenol or aluminium chlorohydrate.
3. The deodorant composition of claim 2 wherein the antimicrobial agent is a composition of dichlorobenzyl alcohol, aluminum chlorohydrate, and piroctone olamine, and the deodorant composition contains 0.01-0.15% by mass of dichlorobenzyl alcohol, 0.01-9.55% by mass of aluminum chlorohydrate, and 0.05-0.3% by mass of piroctone olamine.
4. Deodorant composition according to claim 1, characterized in that the humectant is selected from one or more of betaine, polyol, trehalose, hyaluronic acid.
5. The deodorant composition of claim 4 wherein the humectant is a composition of propylene glycol and trehalose, and the deodorant composition comprises 0.5-6% by weight of propylene glycol and 0.1-4% by weight of trehalose.
6. Deodorant composition according to claim 1, characterized in that the antioxidant is selected from one or more of tocopheryl acetate, butylated hydroxytoluene, sugar cane extract, green tea extract, persimmon extract, VC derivatives.
7. Deodorant composition according to claim 1, characterized in that the pH adjusting agent is selected from one or more of citric acid, lactic acid, glycolic acid, fruit acids, triethyl citrate.
8. Deodorant composition according to claim 1, characterized in that the deodorant composition has a pH value of 4-8.
9. The preparation method of the deodorizing composition is characterized in that the solvent, the tromethamine, the humectant, the antibacterial agent and the antioxidant which are weighed according to the proportion are mixed and stirred until the raw materials are completely dissolved to obtain a mixture;
adding the pH regulator weighed according to the proportion into the mixture, regulating the pH to 4-8, finally adding the aromatic weighed according to the proportion, and uniformly stirring.
10. Use of a deodorant composition according to any one of claims 1 to 8 in a deodorant product which may be a personal care product, a household care product, a pet product or an in-car product.
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Application publication date: 20201218 |