CN112023019A - 一种具有降高尿酸作用的含活性多糖药物及其制备方法 - Google Patents

一种具有降高尿酸作用的含活性多糖药物及其制备方法 Download PDF

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CN112023019A
CN112023019A CN202010970484.8A CN202010970484A CN112023019A CN 112023019 A CN112023019 A CN 112023019A CN 202010970484 A CN202010970484 A CN 202010970484A CN 112023019 A CN112023019 A CN 112023019A
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powder
vitamin
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uric acid
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李婷婷
费韶翔
于国阳
孙纪新
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Shanghai University of Medicine and Health Sciences
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Abstract

本发明公开了一种具有降高尿酸作用的含活性多糖药物及其制备方法，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉8‑15份、红豆杉多糖5‑12份、木瓜7‑15份、蝮蛇6‑11份、薏苡仁7‑13份、芹菜粉11‑20份、牛蒡根粉11‑19份、玉米须粉1‑15份、蛋白核小球藻粉3‑16份、维生素6‑19份、食用辅料11‑30份、桑黄5‑15份。本发明的含活性多糖药物各原料协同增效，降尿酸效果显著。

Description

一种具有降高尿酸作用的含活性多糖药物及其制备方法
技术领域
本发明涉及医药技术领域，尤其涉及一种具有降高尿酸作用的含活性多糖药物及其制备方法。
背景技术
尿酸是人体内嘌呤代谢的终产物，体内尿酸每日的生成量和***量大约相等，但当体内嘌呤代谢紊乱时尿酸含量便会升高，由于尿酸的溶解度小，体内过多时可形成***或痛风。高尿酸血症是指血液中的尿酸浓度超出正常范围的一种机体状态，一般认为男性血液中的尿酸浓度大于400μmol/L时，女性血液中的尿酸浓度大于360μmol/L时应考虑为高尿酸血症。近年的研究表明，高尿酸血症不仅是痛风最重要的生化基础，而且也是引起高血压、高脂血症、动脉粥样硬化、肥胖、胰岛素抵抗、代谢综合征心血管疾病发生和死亡的重要因素，已成为威胁人类健康的主要代谢性疾病之一。
目前临床常用药物有非甾类抗炎药、秋水仙碱、糖皮质激素、丙磺舒、苯澳马隆、别嘌呤醇，治疗效果显著，但是它们都存在不同程度的毒副作用和不良反应，损害肝脏、神经***，引起皮肤过敏、威胁生命的超敏***反应等。
发明内容
本发明的目的是针对现有技术中的不足，提供一种具有降高尿酸作用的含活性多糖药物及其制备方法，该含活性多糖药物各原料协同增效，降尿酸效果显著。
为实现上述目的，本发明采取的技术方案是：
本发明第一方面提供一种具有降高尿酸作用的含活性多糖药物，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉8-15份、红豆杉多糖5-12份、木瓜7-15份、蝮蛇6-11份、薏苡仁7-13份、芹菜粉11-20份、牛蒡根粉11-19份、玉米须粉1-15份、蛋白核小球藻粉3-16份、维生素6-19份、食用辅料11-30份、桑黄5-15份。
优选地，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉10-13份、红豆杉多糖7-10份、木瓜9-14份、蝮蛇8-10份、薏苡仁8-11份、芹菜粉17-20份、牛蒡根粉16-18份、玉米须粉13-15份、蛋白核小球藻粉14-16份、维生素10-15份、食用辅料12-29份、桑黄8-12份。
优选地，所述维生素为维生素A、维生素D、维生素E、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、烟酸、叶酸、泛酸、胆碱和烟酰胺中的一种或几种。
优选地，所述食用辅料为赋形剂、稳定剂、增味剂和护色剂中一种或几种。
本发明第二方面提供所述的含活性多糖药物的制备方法，包括如下步骤：
S1、按重量份称取所述木瓜和蝮蛇，加12-15倍量水，加热提取数次，滤过，合并滤液，滤液浓缩至65-75℃测定相对密度为1.2-1.4的清膏；按重量份称取所述薏苡仁，粉碎成细粉，过60-90目筛；
S2、按重量份称取所述海洋鱼低聚肽粉、红豆杉多糖、芹菜粉、牛蒡根粉、玉米须粉、蛋白核小球藻粉、维生素、食用辅料和桑黄，并加入经步骤S1制得的所述清膏和薏苡仁粉，混匀制得所述含活性多糖药物制剂。
优选地，S1中，所述加热提取2-3次，每次2-3小时。
优选地，S2中，所述含活性多糖药物制剂的剂型为片剂、胶囊、粉剂、丸剂或颗粒剂。
本发明第三方面提供所述的含活性多糖药物在制备降高尿酸作用的保健品、食品或药物中的应用。
本发明采用以上技术方案，与现有技术相比，具有如下技术效果：
1、本发明中的红豆杉多糖具有优异的降尿酸及其降肌酐的效果，并对肾脏有保护作用，用红豆杉多糖为活性成分制成药物在临床实验中表现红豆杉多糖有明显的降尿酸效果。海洋鱼低聚肽粉功能为降低尿酸，缓解痛风；延长肌肉运动时间，增加肌肉运动强度；减轻发炎现象；降低胃溃疡症状，加速愈伤；减缓肌肉老化无力症状；加强神经反应传导速度；降低心肌缺血及脑部缺血伤害。
2、本发明中的木瓜为蔷薇科植物贴梗海棠的干燥近成熟果实，具有舒筋活络和胃化湿的作用；用于湿痹拘挛、腰膝关节酸重疼痛、转筋挛痛、脚气水肿等病症的治疗具有显著的效果。蝮蛇为蝰科动物除去内脏的干燥全体，具有祛风、镇痛、解毒、强壮、下乳等功效；用于风湿痹痛、麻风、***、结核、疮疖、体虚、多汗、乳汁不足等病症的治疗具有显著的效果。薏苡仁为禾本科植物薏苡的干燥成熟种仁，具有利水渗湿、健脾止泻、除痹、脓、解毒散结等功效；用于水肿、脚气、小便不利、脾虚泄泻，湿痹拘挛、肺痈、肠痈、赘疣、癌肿等病症的治疗具有显著的效果。
3、本发明采用将芹菜粉、牛蒡根粉、玉米须粉和蛋白核小球藻粉进行组合作为原料；其中芹菜粉性凉，味甘辛，无毒；入肝，胆，心包经；主治清热平肝除烦，祛风利湿消肿。配以苦寒牛蒡根粉，祛风热，消肿毒；苦寒降泄以镇胃气、通利泻热以降湿邪。玉米须粉甘平能利水消肿，泄热平肝，利尿作用极佳。配以蛋白核小球藻的清热解毒，排酸降浊功能，让痹证从经络到脏腑达到补益气分，健脾利湿，祛风散热，排酸降浊之功效。这4种组分之间协同增效，降尿酸的效果明显优于单一或两三种原料的组合，达到有效降尿酸的效果，且无毒副作用。
4、本发明加入了多种维生素，维生素的加入与其他组份相互作用，加快了药物有效成分的溶出速度，使药物组合物具有很好的发挥效果。
具体实施方式
下面结合具体实施例对本发明作进一步说明，但不作为本发明的限定。
需要说明的是，在不冲突的情况下，本发明中的实施例及实施例中的特征可以相互组合。
实施例1
一种具有降高尿酸作用的含活性多糖药物，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉8份、红豆杉多糖5份、木瓜7份、蝮蛇6份、薏苡仁7份、芹菜粉11份、牛蒡根粉11份、玉米须粉1份、蛋白核小球藻粉3份、维生素A6份、增味剂11份、桑黄5份。
上述含活性多糖药物的制备方法，包括如下步骤：
S1、按重量份称取所述木瓜和蝮蛇，加12倍量水，加热提取2次，每次2小时，滤过，合并滤液，滤液浓缩至65℃测定相对密度为1.2的清膏；按重量份称取所述薏苡仁，粉碎成细粉，过60目筛；
S2、按重量份称取所述海洋鱼低聚肽粉、红豆杉多糖、芹菜粉、牛蒡根粉、玉米须粉、蛋白核小球藻粉、维生素、食用辅料和桑黄，并加入经步骤S1制得的所述清膏和薏苡仁粉，混匀，制得所述含活性多糖药物片剂。
实施例2
一种具有降高尿酸作用的含活性多糖药物，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉11份、红豆杉多糖8份、木瓜12份、蝮蛇9份、薏苡仁12份、芹菜粉18份、牛蒡根粉16份、玉米须粉7份、蛋白核小球藻粉10份、维生素B111份、赋形剂25份、桑黄9份。
上述含活性多糖药物的制备方法，包括如下步骤：
S1、按重量份称取所述木瓜和蝮蛇，加13倍量水，加热提取3次，每次2.5小时，滤过，合并滤液，滤液浓缩至70℃测定相对密度为1.3的清膏；按重量份称取所述薏苡仁，粉碎成细粉，过80目筛；
S2、按重量份称取所述海洋鱼低聚肽粉、红豆杉多糖、芹菜粉、牛蒡根粉、玉米须粉、蛋白核小球藻粉、维生素、食用辅料和桑黄，并加入经步骤S1制得的所述清膏和薏苡仁粉，混匀制得所述含活性多糖药物胶囊。
实施例3
一种具有降高尿酸作用的含活性多糖药物，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉15份、红豆杉多糖12份、木瓜15份、蝮蛇11份、薏苡仁13份、芹菜粉20份、牛蒡根粉19份、玉米须粉15份、蛋白核小球藻粉16份、烟酸19份、稳定剂30份、桑黄15份。
上述含活性多糖药物的制备方法，包括如下步骤：
S1、按重量份称取所述木瓜和蝮蛇，加15倍量水，加热提取3次，每次3小时，滤过，合并滤液，滤液浓缩至75℃测定相对密度为1.4的清膏；按重量份称取所述薏苡仁，粉碎成细粉，过90目筛；
S2、按重量份称取所述海洋鱼低聚肽粉、红豆杉多糖、芹菜粉、牛蒡根粉、玉米须粉、蛋白核小球藻粉、维生素、食用辅料和桑黄，并加入经步骤S1制得的所述清膏和薏苡仁粉，混匀制得所述含活性多糖药物颗粒剂。
应用例
患者资料：患者150例，其中男性100例，年龄分布在35-75岁；女性50例，年龄分布在35-75岁。
诊断标准：患者关节疼痛，夜间发作，难以入眠；血尿酸增高，男性高于6.0mg/dL，女性高于5.0mg/dL；具有痛风石。
服用方法：每天3次，每次2片或2颗实施1、实施2或实施例3中制得的含活性多糖药物制剂，早中晚各一次，连续服用7周。
功效评定标准：治愈：实验室检查血尿酸值正常，关节疼痛症状消失，痛风石去除；好转：实验室检查血尿酸值降低，关节肿胀消退，疼痛缓解，痛风石明显缩小；无效：实验室检查血尿酸值及症状无变化，痛风石无变化。试验结果如表1所示：
表1
Figure BDA0002683854630000051
由表1中数据可知，本发明中含活性多糖药物各原料进行合理配比，科学配伍，各组分之间发挥了协同作用，合理搭配食用辅料，可制成具有显著降尿酸效果、且无副作用的片剂、胶囊、粉剂、丸剂或颗粒剂等保健品、食品或药物，该具有显著降尿酸效果的含活性多糖药物，可以使患者在服用本降尿酸药物7周后，降尿酸的有效率可以达到97.3％以上。
以上所述仅为本发明较佳的实施例，并非因此限制本发明的实施方式及保护范围，对于本领域技术人员而言，应当能够意识到凡运用本发明说明书内容所作出的等同替换和显而易见的变化所得到的方案，均应当包含在本发明的保护范围内。

Claims (8)

1.一种具有降高尿酸作用的含活性多糖药物，其特征在于，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉8-15份、红豆杉多糖5-12份、木瓜7-15份、蝮蛇6-11份、薏苡仁7-13份、芹菜粉11-20份、牛蒡根粉11-19份、玉米须粉1-15份、蛋白核小球藻粉3-16份、维生素6-19份、食用辅料11-30份、桑黄5-15份。
2.根据权利要求1所述的具有降高尿酸作用的含活性多糖药物，其特征在于，所述含活性多糖药物包括以下重量份的组分：海洋鱼低聚肽粉10-13份、红豆杉多糖7-10份、木瓜9-14份、蝮蛇8-10份、薏苡仁8-11份、芹菜粉17-20份、牛蒡根粉16-18份、玉米须粉13-15份、蛋白核小球藻粉14-16份、维生素10-15份、食用辅料12-29份、桑黄8-12份。
3.根据权利要求1所述的具有降高尿酸作用的含活性多糖药物，其特征在于，所述维生素为维生素A、维生素D、维生素E、维生素C、维生素B1、维生素B2、维生素B6、维生素B12、烟酸、叶酸、泛酸、胆碱和烟酰胺中的一种或几种。
4.根据权利要求1所述的具有降高尿酸作用的含活性多糖药物，其特征在于，所述食用辅料为赋形剂、稳定剂、增味剂和护色剂中一种或几种。
5.根据权利要求1-4任一项所述的含活性多糖药物的制备方法，其特征在于，包括如下步骤：
S1、按重量份称取所述木瓜和蝮蛇，加12-15倍量水，加热提取数次，滤过，合并滤液，滤液浓缩至65-75℃测定相对密度为1.2-1.4的清膏；按重量份称取所述薏苡仁，粉碎成细粉，过60-90目筛；
S2、按重量份称取所述海洋鱼低聚肽粉、红豆杉多糖、芹菜粉、牛蒡根粉、玉米须粉、蛋白核小球藻粉、维生素、食用辅料和桑黄，并加入经步骤S1制得的所述清膏和薏苡仁粉，混匀制得所述含活性多糖药物制剂。
6.根据权利要求5所述的含活性多糖药物的制备方法，其特征在于，S1中，所述加热提取2-3次，每次2-3小时。
7.根据权利要求1所述的含活性多糖药物的制备方法，其特征在于，S2中，所述含活性多糖药物制剂的剂型为片剂、胶囊、粉剂、丸剂或颗粒剂。
8.根据权利要求1-4任一项所述的含活性多糖药物在制备降高尿酸作用的保健品、食品或药物中的应用。
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