CN111991610A - Antibacterial healing-promoting spunlace nonwoven dressing and preparation method thereof - Google Patents
Antibacterial healing-promoting spunlace nonwoven dressing and preparation method thereof Download PDFInfo
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- CN111991610A CN111991610A CN202010835769.0A CN202010835769A CN111991610A CN 111991610 A CN111991610 A CN 111991610A CN 202010835769 A CN202010835769 A CN 202010835769A CN 111991610 A CN111991610 A CN 111991610A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Abstract
The invention belongs to the technical field of functional textile materials and biomedical materials, and discloses an antibacterial healing-promoting spunlace non-woven fabric dressing and a preparation method thereof. The preparation method comprises the following steps: putting the cleaned and dried spunlace non-woven fabric into a mixed solution of 2-methylimidazole and zinc salt, standing, aging, taking out, naturally drying, soaking into a recombinant human epidermal growth factor (rhEGF) solution, adsorbing the rhEGF, and then carrying out vacuum drying to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing. The invention directly adsorbs the rhEGF by utilizing the ultrahigh adsorption performance of the ZIF-8, and realizes the stable load and the long-acting sustained drug release of the rhEGF on the ZIF-8 coated spunlace non-woven fabric. The antibacterial healing-promoting spunlace non-woven fabric dressing prepared by the preparation method disclosed by the invention has the effects of resisting bacteria and promoting healing, and can be used for developing novel medical wrapping materials and wound dressings.
Description
Technical Field
The invention belongs to the technical field of functional textile materials and biomedical materials, and particularly relates to an antibacterial healing-promoting spunlace non-woven fabric dressing and a preparation method thereof.
Background
Spunlace nonwoven fabrics have been widely used in medical products, such as medical dressing materials, wound dressings, medical gauze, etc., due to their moisture absorption and air permeability. When the spunlace nonwoven fabric is used as a wound dressing, the basic requirement is to have antibacterial property, and part of antibacterial spunlace nonwoven fabrics appear on the market at present. Another requirement of the functional dressing is healing promotion, the healing promotion medicament is slowly and continuously released by combining with the dressing, the wound healing is effectively promoted, and the wound healing dressing has important application value, and the current spunlace non-woven fabric dressing with the healing promotion function is rarely reported.
The recombinant human epidermal growth factor (rhEGF) can start the wound tissue cell repair process and accelerate wound healing. However, the healing promoting effect of spraying rhEGF is not ideal, because the liquid agent is quickly lost from the wound surface or diluted by the exudate, the due effect cannot be exerted, and the infection risk is increased by frequently opening the wound surface and spraying rhEGF. Therefore, the above problems can be solved by selecting a suitable carrier to immobilize rhEGF for slow sustained release.
Disclosure of Invention
In view of the above, the invention provides an antibacterial healing-promoting spunlace nonwoven fabric dressing and a preparation method thereof. The preparation method realizes the stable load and the long-acting sustained drug release of the rhEGF on the ZIF-8 coated spunlace non-woven fabric, so that the obtained antibacterial healing-promoting spunlace non-woven fabric dressing has the effects of resisting bacteria and promoting healing.
In order to solve the problems, the technical scheme of the invention is as follows:
a preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) washing the spunlace nonwoven fabric with deionized water and acetone and drying to remove oil and other impurities;
(2) respectively dissolving 2-methylimidazole and zinc salt in a solvent to prepare a 2-methylimidazole solution and a zinc salt solution, uniformly mixing and stirring the 2-methylimidazole solution and the zinc salt solution to obtain a mixed solution, then placing the spunlace non-woven fabric treated in the step (1) into the mixed solution, standing and aging for 8-24 hours, taking out, and naturally drying for 12-24 hours to obtain a ZIF-8 coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into a recombinant human epidermal growth factor solution for 12-36 h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing recombinant human epidermal growth factor (rhEGF);
(4) and (4) coating the ZIF-8 adsorbing the recombinant human epidermal growth factor (rhEGF) obtained in the step (3) on the spunlace nonwoven fabric, and drying for 6-12 hours in vacuum to obtain the antibacterial healing-promoting spunlace nonwoven fabric dressing.
Preferably, the spunlace nonwoven fabric is made of one or more of terylene, chinlon, polypropylene fiber, viscose fiber, chitin fiber, tencel, silk, bamboo fiber, wood pulp fiber and alginate fiber.
Preferably, the zinc salt is zinc nitrate hexahydrate or zinc acetate dihydrate.
Preferably, the solvent is one of methanol, ethanol and deionized water.
Preferably, the molar ratio of the 2-methylimidazole to the zinc salt in the mixed solution is 2-5: 1.
Preferably, the concentration of the 2-methylimidazole solution is 0.1-1.2 mol/L, and the concentration of the zinc salt solution is 0.05-0.6 mol/L respectively.
Preferably, the concentration of the recombinant human epidermal growth factor solution is 1-10 mol/L, and the solvent is PBS buffer solution with pH of 7.
Preferably, the natural drying and vacuum drying temperature is 5-30 ℃.
The invention also provides the antibacterial healing-promoting spunlace nonwoven dressing prepared by the preparation method.
Compared with the prior art, the invention has the beneficial technical effects that:
(1) the ZIF-8 coated spunlace non-woven fabric is prepared by adopting the technical means of direct impregnation, standing ageing, normal-temperature drying and the like, has the characteristics of simple process, low energy consumption, high efficiency and the like, and is a clean production mode.
(2) The invention utilizes the ultrahigh adsorption performance of ZIF-8 to directly adsorb the wound healing promoting drug recombinant human epidermal growth factor (rhEGF), and realizes the stable load and long-acting sustained drug release of the rhEGF on the ZIF-8 coated spunlace non-woven fabric.
(3) The antibacterial healing-promoting spunlace non-woven fabric dressing has both antibacterial (ZIF-8 has a better antibacterial effect) and healing-promoting effects, can be used for developing novel medical wrapping materials and wound dressings, and is directly applied to clinical treatment.
Detailed Description
The following examples further illustrate the present invention but are not to be construed as limiting the invention. Modifications and substitutions to methods, procedures, or conditions of the invention may be made without departing from the spirit and substance of the invention. Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art.
Example 1
A preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) respectively cleaning 10g of terylene/wood pulp fiber spunlace non-woven fabric by using deionized water and acetone, and drying in an oven at 60 ℃ to remove oil agents and other impurities for later use;
(2) dissolving 1.2g of 2-methylimidazole in 100mL of methanol to prepare a 2-methylimidazole solution, dissolving 2g of zinc nitrate hexahydrate in 100mL of methanol to prepare a zinc nitrate solution, mixing the two solutions, fully stirring, adding the spunlace non-woven fabric treated in the step (1), standing and aging for 8 hours, taking out, and naturally drying at room temperature for 12 hours to prepare a ZIF-8-coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into 50mL of rhEGF solution with the concentration of 1mol/L for 12h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing rhEGF; the solvent of the rhEGF solution was PBS buffer with pH 7.
(4) And (4) drying the rhEGF-adsorbed ZIF-8 coated spunlace non-woven fabric obtained in the step (3) at room temperature for 6 hours in vacuum to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing.
Example 2
A preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) respectively cleaning 10g of terylene/wood pulp fiber spunlace non-woven fabric by using deionized water and acetone, and drying in an oven at 60 ℃ to remove oil agents and other impurities for later use;
(2) dissolving 1.5g of 2-methylimidazole in 100mL of ethanol to prepare a 2-methylimidazole solution, dissolving 2.5g of zinc nitrate hexahydrate in 100mL of ethanol to prepare a zinc nitrate solution, mixing the two solutions, fully stirring, adding the spunlace non-woven fabric treated in the step (1), standing and aging for 12 hours, taking out, and naturally drying at room temperature for 18 hours to prepare a ZIF-8 coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into 50mL of rhEGF solution with the concentration of 2mol/L for 24h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing rhEGF; the solvent of the rhEGF solution was PBS buffer with pH 7.
(4) And (4) drying the rhEGF-adsorbed ZIF-8 coated spunlace non-woven fabric obtained in the step (3) at room temperature for 8 hours in vacuum to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing.
Example 3
A preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) respectively cleaning 10g of nylon/viscose spunlace nonwoven fabric with deionized water and acetone, and drying in an oven at 60 ℃ to remove oil and other impurities for later use;
(2) dissolving 2.8g of 2-methylimidazole in 50mL of deionized water to prepare a 2-methylimidazole solution, dissolving 5g of zinc nitrate hexahydrate in 50mL of deionized water to prepare a zinc nitrate solution, mixing the two solutions, fully stirring, adding the spunlace non-woven fabric treated in the step (1), standing and aging for 18 hours, taking out, and naturally drying at room temperature for 24 hours to prepare a ZIF-8-coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into 50mL of rhEGF solution with the concentration of 5mol/L for 24h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing rhEGF; the solvent of the rhEGF solution was PBS buffer with pH 7.
(4) And (4) drying the rhEGF-adsorbed ZIF-8 coated spunlace non-woven fabric obtained in the step (3) at room temperature for 12 hours in vacuum to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing.
Example 4
A preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) respectively cleaning 10g of polypropylene fiber/bamboo fiber spunlace non-woven fabric with deionized water and acetone, and drying in an oven at 60 ℃ to remove oil agents and other impurities for later use;
(2) dissolving 3.6g of 2-methylimidazole in 50mL of methanol to prepare a 2-methylimidazole solution, dissolving 5g of zinc acetate dihydrate in 50mL of methanol to prepare a zinc acetate solution, mixing the two solutions, fully stirring, adding the spunlace non-woven fabric treated in the step (1), standing and aging for 24 hours, taking out, and naturally drying at room temperature for 18 hours to prepare a ZIF-8 coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into 50mL of rhEGF solution with the concentration of 8mol/L for 36h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing rhEGF; the solvent of the rhEGF solution was PBS buffer with pH 7.
(4) And (4) drying the rhEGF-adsorbed ZIF-8 coated spunlace non-woven fabric obtained in the step (3) at room temperature for 12 hours in vacuum to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing.
Example 5
A preparation method of an antibacterial healing-promoting spunlace nonwoven dressing comprises the following steps:
(1) respectively cleaning 10g of polypropylene fiber/alginate fiber spunlace non-woven fabric with deionized water and acetone, and drying in a 60 ℃ drying oven to remove oil agents and other impurities for later use;
(2) dissolving 4.92g of 2-methylimidazole in 50mL of ethanol to prepare a 2-methylimidazole solution, dissolving 6.58g of zinc acetate dihydrate in 50mL of ethanol to prepare a zinc acetate solution, mixing the two solutions, fully stirring, adding the spunlace non-woven fabric treated in the step (1), standing and aging for 24 hours, taking out, and naturally drying at room temperature for 24 hours to prepare a ZIF-8 coated spunlace non-woven fabric;
(3) soaking the ZIF-8 coated spunlace non-woven fabric obtained in the step (2) into 50mL of rhEGF solution with the concentration of 10mol/L for 36h, and taking out to obtain a ZIF-8 coated spunlace non-woven fabric adsorbing rhEGF; the solvent of the rhEGF solution was PBS buffer with pH 7.
(4) And (4) drying the rhEGF-adsorbed ZIF-8 coated spunlace non-woven fabric obtained in the step (3) at room temperature for 12 hours in vacuum to prepare the antibacterial healing-promoting spunlace non-woven fabric dressing.
It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. The preparation method of the antibacterial healing-promoting spunlace nonwoven dressing is characterized by comprising the following steps:
(1) washing the spunlace nonwoven fabric with deionized water and acetone and drying to remove oil and other impurities;
(2) respectively dissolving 2-methylimidazole and zinc salt in a solvent to prepare a 2-methylimidazole solution and a zinc salt solution, uniformly mixing and stirring the 2-methylimidazole solution and the zinc salt solution to obtain a mixed solution, then placing the spunlace non-woven fabric treated in the step (1) into the mixed solution, standing and aging for 8-24 hours, taking out, and naturally drying for 12-24 hours to obtain a ZIF-8 coated spunlace non-woven fabric;
(3) soaking the ZIF-8-coated spunlace non-woven fabric obtained in the step (2) into a recombinant human epidermal growth factor solution for 12-36 h, and taking out to obtain a ZIF-8-coated spunlace non-woven fabric adsorbing the recombinant human epidermal growth factor;
(4) and (4) drying the ZIF-8-coated spunlace non-woven fabric adsorbing the recombinant human epidermal growth factor obtained in the step (3) in vacuum for 6-12 hours to obtain the antibacterial healing-promoting spunlace non-woven fabric dressing.
2. The method of claim 1, wherein the spunlace nonwoven fabric is made of one or more of polyester, nylon, polypropylene, viscose, chitin, tencel, silk, bamboo, wood pulp, and alginate fibers.
3. The method according to claim 1, wherein the zinc salt is zinc nitrate hexahydrate or zinc acetate dihydrate.
4. The method of claim 1, wherein the solvent is one of methanol, ethanol, and deionized water.
5. The preparation method according to claim 1, wherein the molar ratio of the 2-methylimidazole to the zinc salt in the mixed solution is 2-5: 1.
6. The method according to claim 1, wherein the concentration of the 2-methylimidazole solution is 0.1 to 1.2mol/L, and the concentration of the zinc salt solution is 0.05 to 0.6 mol/L.
7. The method according to claim 1, wherein the concentration of the recombinant hEGF solution is 1-10 mol/L, and the solvent is PBS buffer solution with pH 7.
8. The method according to claim 1, wherein the natural drying and vacuum drying temperature is 5 to 30 ℃.
9. The antibacterial healing-promoting spunlace nonwoven dressing prepared by the preparation method of any one of claims 1 to 8.
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| CN202010835769.0A CN111991610A (en) | 2020-08-19 | 2020-08-19 | Antibacterial healing-promoting spunlace nonwoven dressing and preparation method thereof |
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| CN202010835769.0A CN111991610A (en) | 2020-08-19 | 2020-08-19 | Antibacterial healing-promoting spunlace nonwoven dressing and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115153863A (en) * | 2022-06-21 | 2022-10-11 | 深圳市兴业卓辉实业有限公司 | Medical antibacterial drape for surgical operation treatment and preparation method thereof |
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| CN115153863A (en) * | 2022-06-21 | 2022-10-11 | 深圳市兴业卓辉实业有限公司 | Medical antibacterial drape for surgical operation treatment and preparation method thereof |
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Application publication date: 20201127 |