CN111973724A

CN111973724A - Traditional Chinese medicine composition for treating fever of unknown origin

Info

Publication number: CN111973724A
Application number: CN202010802170.7A
Authority: CN
Inventors: 茹凝玉; 马亮; 刘焕; 崔媛媛; 邱忠营; 王晓龙; 刘莉
Original assignee: Xian Medical University
Current assignee: Xian Medical University
Priority date: 2020-08-11
Filing date: 2020-08-11
Publication date: 2020-11-24

Abstract

The invention discloses a traditional Chinese medicine composition for treating fever of unknown origin, which comprises the following components in percentage by mass: 12-24 parts of radix bupleuri, 6-9 parts of radix scutellariae, 6-9 parts of rhizoma pinellinae praeparata, 10-30 parts of radix paeoniae alba, 10-30 parts of radix codonopsis, 15-30 parts of radix astragali, 10-15 parts of rhizoma atractylodis macrocephalae, 15-30 parts of semen coicis, 9-15 parts of angelica sinensis, 6-15 parts of pericarpium citri reticulatae, 6-15 parts of ginger and 6-9 parts of raw liquorice. In the formula, the bupleurum root and the baical skullcap root can relieve triple energizer and reduce fire, and the white peony root is a special medicine for reducing fire to strengthen the power of astringing and reducing fire; fa ban Xia can lower stomach qi and help to lower the pathogenic fire. Radix codonopsitis, radix astragali, rhizoma atractylodis macrocephalae, angelica, rhizoma pinellinae praeparata, dried orange peel, semen coicis, ginger and liquorice have the effects of eliminating dampness, strengthening spleen, harmonizing stomach, warming middle-jiao and removing heat with sweet and warm natured drugs.

Description

Traditional Chinese medicine composition for treating fever of unknown origin

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating fever of unknown origin.

Background

Fever is the most common clinical symptom with numerous reasons behind it, and clinically it is mainly divided into fever caused by infection and non-infection factors. Although the tests for fever are very numerous, some patients have not been examined for many times to determine the cause of the disease, and thus cannot be treated in a targeted manner to delay the disease condition. For patients who have long-term fever and can not clear the cause of the disease, some clinical methods at present adopt antituberculosis drugs for treatment, but the period is long and the side effect is great. The traditional Chinese medicine has abundant theoretical and practical experiences on fever, and clinically, the fever with unknown reasons is treated according to the internal injury fever and the theory of reducing fever caused by fire, so that the curative effect is obvious.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating fever caused by unknown reasons, which can treat fever caused by unknown reasons and has remarkable curative effect.

The first technical scheme of the invention is as follows: a traditional Chinese medicine composition for treating fever of unknown origin comprises the following components in percentage by mass: 12-24 parts of radix bupleuri, 6-9 parts of radix scutellariae, 6-9 parts of rhizoma pinellinae praeparata, 10-30 parts of radix paeoniae alba, 10-30 parts of radix codonopsis, 15-30 parts of radix astragali, 10-15 parts of rhizoma atractylodis macrocephalae, 15-30 parts of semen coicis, 9-15 parts of angelica sinensis, 6-15 parts of pericarpium citri reticulatae, 6-15 parts of ginger and 6-9 parts of raw liquorice.

The technical solution adopted by the invention is also characterized in that,

24 parts of radix bupleuri, 9 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 30 parts of radix paeoniae alba, 15 parts of raw codonopsis pilosula, 20 parts of raw astragalus membranaceus, 15 parts of raw bighead atractylodes rhizome, 20 parts of semen coicis, 15 parts of angelica sinensis, 10 parts of pericarpium citri reticulatae, 15 parts of ginger and 6 parts of raw liquorice.

The mass ratio of the bupleurum to the scutellaria is 8: 3.

The second technical scheme adopted by the invention is as follows: a decoction of a Chinese medicinal composition for treating fever of unknown origin, which comprises the Chinese medicinal composition of claim 1.

Decocting the above materials, removing residues, decocting again, and concentrating.

The invention has the beneficial effects that: the ratio of radix bupleuri to radix scutellariae is 8:3 in the classic ratio in the treatise on typhoid fever, radix paeoniae alba astringes and lowers ministerial fire, rhizoma pinellinae praeparata lowers stomach qi to help lower ministerial fire, semen armeniacae amarae lowers lung qi to help lower ministerial fire, and oyster is used for growing heavy ballast to help lower ministerial fire. Dangshen, astragalus, bighead atractylodes rhizome, dried orange peel and coix seed have the functions of tonifying spleen and promoting diuresis, regulating qi and harmonizing stomach and are used for assisting the circulation of middle-jiao energy. For qi and blood deficiency due to long-term illness, radix astragali, radix Angelicae sinensis, and rhizoma Zingiberis recens are used to nourish blood. Raw gan Cao harmonizes property of herbs, regulates middle energizer, removes toxicity and reduces fever. The medicament for treating fever of unknown origin can be preferably prepared into concentrated granules, takes the meaning of decoction, is easier to take effect in the form of decoction after being taken with boiled water, and is tablets (dispersible tablets) and capsules (hard capsules).

Detailed Description

The present invention will be further described with reference to the following embodiments.

A medicament for treating fever of unknown origin comprises the following components in percentage by mass: 12-24 parts of radix bupleuri, 6-9 parts of radix scutellariae, 6-9 parts of rhizoma pinellinae praeparata, 10-30 parts of radix paeoniae alba, 10-30 parts of radix codonopsis, 15-30 parts of radix astragali, 10-15 parts of raw rhizoma atractylodis macrocephalae, 15-30 parts of semen coicis, 9-15 parts of angelica sinensis, 6-15 parts of pericarpium citri reticulatae, 6-15 parts of ginger and 6-9 parts of raw liquorice.

The preferred scheme is as follows: 24 parts of radix bupleuri, 9 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 30 parts of radix paeoniae alba, 15 parts of raw codonopsis pilosula, 20 parts of raw astragalus membranaceus, 15 parts of raw bighead atractylodes rhizome, 20 parts of semen coicis, 15 parts of angelica sinensis, 10 parts of pericarpium citri reticulatae, 15 parts of ginger and 6 parts of raw liquorice.

The ratio of the radix bupleuri to the radix scutellariae is 8:3, the radix paeoniae alba can play a role in relieving the triple warmer of the body, the rhizoma pinellinae praeparata can astringe and descend the body fire, the rhizoma pinellinae praeparata can descend the stomach qi to help descend the body fire, the semen armeniacae amarae can descend the lung qi to help descend the body fire, and the oysters grow heavy and weigh down to help descend the body fire. Dangshen, astragalus, bighead atractylodes rhizome, dried orange peel and coix seed have the functions of tonifying spleen and promoting diuresis, regulating qi and harmonizing stomach and are used for assisting the circulation of middle-jiao energy. For qi and blood deficiency due to long-term illness, radix astragali, radix Angelicae sinensis, and rhizoma Zingiberis recens are used to nourish blood. Raw gan Cao harmonizes property of herbs, regulates middle energizer, removes toxicity and reduces fever.

The medicament for treating fever of unknown origin is generally applied to decoction, and the decoction is taken according to the meaning of decoction and can be absorbed easily and take effect quickly. The prescription has a special decocting method, and the medicines are decocted conventionally and then removed from the residue and decocted again, so that the medicines are fully decocted and concentrated.

In traditional Chinese medicine, fever is divided into internal injury fever and exogenous fever, while fever of unknown origin is mainly internal injury fever, and the discussion of "fire in internal injury" in ancient Chinese medicine in round sports is more classic, and when the body is in blazing with fire in the middle of the body, it is in blazing at the outside and in the case of … … fire in the middle of the body, it is also in blazing at the outside. In the four saint heart sources, there is a prescription of bupleuri radix and Paeoniae radix decoction for treating shaoyang ministerial fire, but there is no specific dosage. In addition, the traditional Chinese medicine has the discussion of 'sweet and warm heat removal', which is different from the fever removal of western medicine and the fever removal of cold and cool medicine of traditional Chinese medicine, the bupleurum root and the scutellaria root in the invention can remove the triple energizer and reduce the fire by matching with the white peony root which is a special medicine for reducing the fire, thereby strengthening the power of astringing and reducing the fire; fa ban Xia can lower stomach qi and help to lower the pathogenic fire. Radix codonopsitis, radix astragali, rhizoma atractylodis macrocephalae, angelica, rhizoma pinellinae praeparata, dried orange peel, semen coicis, ginger and liquorice have the effects of eliminating dampness, strengthening spleen, harmonizing stomach, warming middle-jiao and removing heat with sweet and warm natured drugs.

Example 1

12 parts of radix bupleuri, 9 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 30 parts of radix paeoniae alba, 30 parts of codonopsis pilosula, 30 parts of astragalus membranaceus, 15 parts of raw bighead atractylodes rhizome, 15 parts of semen coicis, 9 parts of angelica sinensis, 15 parts of pericarpium citri reticulatae, 6 parts of ginger and 9 parts of raw liquorice.

Example 2

15 parts of radix bupleuri, 7 parts of scutellaria baicalensis, 6 parts of rhizoma pinellinae praeparata, 15 parts of radix paeoniae alba, 20 parts of codonopsis pilosula, 15 parts of astragalus membranaceus, 12 parts of raw bighead atractylodes rhizome, 25 parts of semen coicis, 12 parts of angelica sinensis, 6 parts of pericarpium citri reticulatae, 10 parts of ginger and 6 parts of raw liquorice.

Example 3

24 parts of radix bupleuri, 8 parts of scutellaria baicalensis, 8 parts of rhizoma pinellinae praeparata, 30 parts of radix paeoniae alba, 15 parts of codonopsis pilosula, 25 parts of astragalus membranaceus, 11 parts of raw bighead atractylodes rhizome, 30 parts of semen coicis, 10 parts of angelica sinensis, 9 parts of pericarpium citri reticulatae, 10 parts of ginger and 8 parts of raw liquorice.

Example 4

12 parts of radix bupleuri, 9 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 15 parts of radix paeoniae alba, 10 parts of codonopsis pilosula, 20 parts of astragalus membranaceus, 10 parts of raw bighead atractylodes rhizome, 21 parts of semen coicis, 10 parts of angelica sinensis, 8 parts of pericarpium citri reticulatae, 6 parts of ginger and 6 parts of raw liquorice.

Typical case

1. Wuyi, female, 17 years old, high two students, Shanxi Typha, leading to intermittent fever in half month in 2010, and visiting the Xijing hospital outpatient service in half month due to the main reason of the year 07, the temperature fluctuation is 37.5-38.3 ℃, the fever occurs every day in the afternoon, and the fever lasts for about 2 hours. The patients are hospitalized in the people's hospital in Shaanxi province in a fashionable way, are hospitalized with fever to be checked, are hospitalized for 1 week, have no obvious abnormality (except infection, hemorrhagic fever, malaria and the like) in relevant inspection in the rheumatism and immunization department in the Xijing hospital, and then are diagnosed in the traditional Chinese medicine department. The patient with intermittent fever mainly has afternoon, white and lusterless complexion, hypodynamia, anorexia, general sleep, pale tongue with white coating and floating and large pulse. The fever due to internal injury is caused by the fever caused by infection except for the patient. Intermittent fever without obvious aversion to cold, it is the syndrome of shaoyang meridian. In addition, the weak symptom can be treated by a method of removing heat with sweet and warm property, so the prescription is modified from Xiaochaihu decoction and Buzhong Yiqi decoction, and the prescription is as follows: 12g of radix bupleuri, 9g of scutellaria baicalensis, 9g of rhizoma pinellinae praeparata, 9g of ginger, 20g of raw astragalus membranaceus, 10g of angelica sinensis, 10g of codonopsis pilosula, 10g of bighead atractylodes rhizome, 6g of ginger, 10g of Chinese date and 6g of raw liquorice. The Chinese medicinal granule is administered in 7 doses, 1 dose daily. The patient in afternoon on day 2 complains that the daughter has no fever, and orders to continue taking the traditional Chinese medicine. The patient parents informed that discharge was achieved after 2 days. After many years, the relation is kept, and patients with uncertain reasons of the same village are recommended to visit the pen-finder in the Dongdu hospital in 2013.

2. Patients in Tian, male, 27 years old and Shanxi Pucheng do work in Zhejiang, no obvious reasons for fever appear, the body temperature is 38.9 ℃ at most, no cough, chest distress and the like exist, clear infection evidence is not found in local hospital examination, chest CT is not abnormal, and the patients still have intermittent fever after taking ibuprofen and cephalosporin antibiotics. After 1 month of intermittent fever, the patient returns to the old, and is introduced by the same village to see the doctor in the traditional Chinese medicine department of Tangdu hospital, the symptoms of intermittent fever, no obvious aversion to cold, occasionally dry mouth and bitter taste, poor appetite, 3-4Kg of weight loss, dark red tongue, white, thick and greasy fur and deep and smooth pulse. Except infection factors, the medicine is treated by reducing pathogenic fire, the damp stagnation of a patient is obvious, and the medicine for eliminating dampness and tonifying spleen is given as the following prescription: 24g of radix bupleuri, 9g of scutellaria baicalensis, 9g of rhizoma pinelliae preparata, 30g of radix paeoniae alba, 20g of raw astragalus membranaceus, 10g of angelica sinensis, 10g of codonopsis pilosula, 10g of bighead atractylodes rhizome, 30g of raw coix seed, 10g of ginger, 10g of Chinese date and 6g of raw liquorice. 5 doses of the traditional Chinese medicine are given. After taking 3 doses, there is no recurrence after treatment.

3. Patient girl, 24 years old, student of the graduate, Shanxi Yuancheng, wenty at Chongqing. In 2011, fever begins to occur in the course of returning home from school in 1 month, the fever is intermittent, the body temperature is 38.5 ℃ at most every day, the doctor can see the doctor repeatedly in the city, the clear reason is not found, and the rest 4 months. Xijing hospital is diagnosed in 2011 at 05 months, and is diagnosed in Xijing hospital traditional Chinese medicine department after no abnormality is found in rheumatology department, besides the upper symptoms, the disease is accompanied by hypodynamia, emaciation, spontaneous heating, the tongue is pale and thick, the pulse is thin on the left, and the right pulse is large and weak. Modified chaihu shao yao tang (Bupleurum and peony decoction), combined with the tongue and vessel of the patient, is added with dampness-eliminating and spleen-invigorating herbs, and the prescription is as follows: 24g of radix bupleuri, 9g of scutellaria baicalensis, 9g of rhizoma pinellinae praeparata, 10g of ginger, 30g of radix paeoniae alba, 10g of codonopsis pilosula, 10g of honey-fried licorice root, 10g of bighead atractylodes rhizome, 30g of poria cocos, 10g of amomum tsao-ko and 30g of raw coix seed, and 20g of angelica sinensis. After 2 weeks, the patient's body temperature was normal, the prescription was adjusted in the later period, menstruation and weight gain, and school was resumed in 9 months.

4. Chen Shi, 17 years old, student of working school, Xian family county, admitted to the hospital 5/2012 because of "12 days fever". Fever after being cooled 24 days after 04 months, body temperature of 40 ℃ at most, fatigue, no discomfort such as chest distress, nausea, vomiting, no joint pain, abdominal pain, diarrhea and the like, no obvious improvement after local clinics give treatments such as 'qingkailing' and 'cef', cough, small amount of white sticky phlegm, headache, nausea, vomiting, continuous pain in upper abdomen, no discomfort such as abdominal distension and diarrhea and the like, and conventional blood in the county and traditional Chinese medicine hospital after 30 days after 4 months: WBC 18.09X 10⁹/L, N87.24%; urine protein ± -v. The cephalosporin anti-infection and ibuprofen suppository antipyretic treatment is given, and the body temperature is increased again after falling. Chest CT: bilateral pleural effusion, 5 months and 4 days for reexamination of conventional WBC 14.97X 10⁹/L，N 88.54％。

Diagnosis and treatment plan: 1. 2, the disease severity is 2, the routine blood-checking, the liver and kidney function, FRT, PCT, CRP, chest and abdomen CT, etc. 3. 0.5g of meropenem per day is used for resisting infection. Local traditional Chinese medicine syndrome differentiation: prescription for yangming meridian (excess heat syndrome): 50g of gypsum, 10g of rhizoma anemarrhenae, 10g of raw licorice, 10g of rice, 10g of coptis chinensis, 10g of scutellaria baicalensis and 10g of gardenia jasminoides ellis. It is prescribed for the hospital, and 3 doses of water are decocted for oral administration (17-19 days for oral administration). The body temperature can be reduced after taking the medicine, the patient has diarrhea, and the body temperature is increased after the diarrhea (4-linked antituberculosis plus dexamethasone is given in the department of living quarters). Syndrome differentiation of professor in traditional Chinese medicine of the institute: yangming latent fire syndrome (yin deficiency with excessive heat): 10g of American ginseng, 10g of dwarf lilyturf tuber, 10g of Chinese thorowax root, 10g of Chinese yam, 20g of gypsum, 10g of common anemarrhena rhizome, 10g of cassia twig, 10g of kudzuvine root, 10g of raw liquoric root, 10g of golden thread, 10g of baical skullcap root and 10g of pittosporum root. The 3 dose of the Chinese medicinal granule is taken 1 dose/day and 2 times. The medicine is taken 22-24 days, the body temperature of the patient is reduced, and the body temperature is raised after diarrhea. (5-joint antituberculosis and dexamethasone stopping administration are given in the department of hospital), the patients stay in hospital for a long time, the symptomatic treatment has no obvious effect, and the consultation of the whole hospital is planned.

When the person who is written with pen sees the patient: the patient has intermittent fever, no aversion to cold, carelessness or easy fever after diarrhea, extremely poor spirit, yellow and white complexion, weakness of the whole body, headache, head rising weakness and incapability of walking, needs to be assisted by family or sit on a wheelchair, anorexia, pale tongue, black and dry fur, thin left pulse, large and superficial right pulse and weakness of sinking. Syndrome differentiation: qi deficiency, loss of ministerial fire, prescription: 24g of radix bupleuri, 9g of scutellaria baicalensis, 9g of rhizoma pinelliae preparata, 30g of radix paeoniae alba, 20g of codonopsis pilosula, 10g of bighead atractylodes rhizome, 30g of raw astragalus membranaceus, 10g of angelica sinensis, 10g of ligusticum wallichii, 6g of ginger, 10g of Chinese date and 6g of raw liquorice. The 3 dose of the Chinese medicinal granule is taken 3 times (25 days to 27 days) with 1 dose/daily water. After the medicine is taken, the body temperature of a patient is 37.1 ℃ at the maximum, the body temperature is increased when the patient vomits due to careless diet, the patient can relieve the disease by self (family members stop taking the oral antituberculosis drugs), then the mother of the patient requires to be discharged, the diagnosis is still unknown during discharge, the treatment is continued by the method, the body temperature of the patient is normal after 3 days, the cassia twig decoction is used for conditioning for 1 week, all symptoms of the patient are cured, and the menstruation comes after 3 weeks.

The traditional Chinese medicine formula of the invention has basic medicines in specific application, is a main medicine and determines a large treatment direction, and other medicines are added or subtracted according to different conditions of patients. The different cases show that the unknown fever cases are rarely concentrated in the process of adjusting and optimizing the prescription, but in clinical application for many years, the ideal curative effect is achieved for the patients by taking the prescription according to the thought.

Claims

1. A traditional Chinese medicine composition for treating fever of unknown origin is characterized by comprising the following components in percentage by mass: 12-24 parts of radix bupleuri, 6-9 parts of radix scutellariae, 6-9 parts of rhizoma pinellinae praeparata, 10-30 parts of radix paeoniae alba, 10-30 parts of radix codonopsis, 15-30 parts of radix astragali, 10-15 parts of rhizoma atractylodis macrocephalae, 15-30 parts of semen coicis, 9-15 parts of angelica sinensis, 6-15 parts of pericarpium citri reticulatae, 6-15 parts of ginger and 6-9 parts of raw liquorice.

2. The traditional Chinese medicine composition for treating fever of unknown origin according to claim 1, which is characterized by further comprising the following components in percentage by mass: 24 parts of radix bupleuri, 9 parts of scutellaria baicalensis, 9 parts of rhizoma pinellinae praeparata, 30 parts of radix paeoniae alba, 15 parts of angelica sinensis, 15 parts of raw codonopsis pilosula, 20 parts of raw astragalus membranaceus, 15 parts of raw bighead atractylodes rhizome, 20 parts of semen coicis, 10 parts of pericarpium citri reticulatae, 10 parts of bitter apricot seed, 15 parts of ginger and 6 parts of raw liquorice.

3. The Chinese medicinal composition for treating fever of unknown origin according to claim 1, wherein the mass ratio of the bupleurum root to the scutellaria root is 8: 3.

4. A decoction of the Chinese medicinal composition for treating fever of unknown origin according to claim 1, wherein the decoction comprises the Chinese medicinal composition according to claim 1.

5. The decoction of the Chinese medicinal composition for treating fever of unknown origin as in claim 4, wherein the decoction is prepared by decocting the herbs first, then removing the residues and decocting again, and then fully decocting and concentrating the decoction.