CN111956859B - 一种含中药成分的抗菌止血创可贴及其制备方法 - Google Patents
一种含中药成分的抗菌止血创可贴及其制备方法 Download PDFInfo
- Publication number
- CN111956859B CN111956859B CN202010971352.7A CN202010971352A CN111956859B CN 111956859 B CN111956859 B CN 111956859B CN 202010971352 A CN202010971352 A CN 202010971352A CN 111956859 B CN111956859 B CN 111956859B
- Authority
- CN
- China
- Prior art keywords
- layer
- band
- aid
- hemostatic
- adhesive backing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 31
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000853 adhesive Substances 0.000 claims abstract description 56
- 230000001070 adhesive effect Effects 0.000 claims abstract description 56
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 37
- 239000000843 powder Substances 0.000 claims abstract description 37
- 206010052428 Wound Diseases 0.000 claims abstract description 36
- 229920001661 Chitosan Polymers 0.000 claims abstract description 31
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 12
- 238000003825 pressing Methods 0.000 claims abstract description 10
- 239000000123 paper Substances 0.000 claims description 16
- 230000001954 sterilising effect Effects 0.000 claims description 15
- 241001313857 Bletilla striata Species 0.000 claims description 14
- 238000005303 weighing Methods 0.000 claims description 14
- 244000131316 Panax pseudoginseng Species 0.000 claims description 13
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 4
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 208000026935 allergic disease Diseases 0.000 claims description 3
- 229920002799 BoPET Polymers 0.000 claims description 2
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 2
- 239000011086 glassine Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000035876 healing Effects 0.000 abstract description 17
- 230000029663 wound healing Effects 0.000 abstract description 6
- 238000002474 experimental method Methods 0.000 abstract description 5
- 235000003143 Panax notoginseng Nutrition 0.000 abstract description 4
- 241000180649 Panax notoginseng Species 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 206010048038 Wound infection Diseases 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 239000012620 biological material Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 231100000241 scar Toxicity 0.000 abstract description 2
- 208000034656 Contusions Diseases 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 230000000474 nursing effect Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 7
- 238000005520 cutting process Methods 0.000 description 7
- 238000007789 sealing Methods 0.000 description 6
- 238000010998 test method Methods 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000000740 bleeding effect Effects 0.000 description 4
- 230000023597 hemostasis Effects 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241001313855 Bletilla Species 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
- A61F13/0263—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer especially adapted for island dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种含中药成分的抗菌止血创可贴及其制备方法,属于医疗用品技术领域。本发明所制备的创可贴由黏性背衬、药物层、壳聚糖止血层和可剥离层组成。黏性背衬由可降解的壳聚糖无纺布制成,药物层是将中药粉末通过粉末压制法制备而成的薄膜,主要包含三七、白芨和牡蛎壳粉末等成分。本发明所制备的创可贴具有良好的止血、消肿止痛、祛疤和抗菌效果。在促进伤口愈合的同时,也防止了愈合过程中伤口感染的出现。本发明所制备的创可贴制造技术简单、操作流出少、制作成本低,适用于大规模生产;同时,该创可贴采用的是新型生物材料,具有环保、无污染和可生物降解等优势。相关实验也表明该创可贴生物相容性好、对伤口无刺激性且、产品无毒副作用。本发明所制备的创可贴可应用于小创口、擦伤及切割伤等浅表性创面伤口的护理,具有推广应用的价值。
Description
技术领域
本发明属于医疗用品技术领域,具体涉及到了一种含中药成分的抗菌止血创可贴。
背景技术
创伤是正常皮肤在外界致伤因子(外力、热、外科手术、电流、化学物质和低温等)和机体内在因素(局部供血不足)共同作用下所发生的损害。伤口的出现一般会伴随着皮肤完整性的破坏和部分正常组织的丢失,从而造成皮肤正常功能受损。伤口修复是一个多细胞和多细胞因子共同参与的复杂过程,创口敷料在治疗和修复伤口的过程中起着重要的作用。早期,人们通过传统的干性敷料对伤口进行处理,即使用纱布或绷带对伤口进行覆盖,从而隔绝外界微生物,避免了伤口的进一步感染,然后通过患者本身的愈合修复能力,来使伤口愈合。创可贴作为一种常见的干性敷料而广泛应用于伤口处理,其主要由平面胶布、吸水层和可剥离层组成,具有止血和护创的作用。它的止血作用主要靠平面胶布的粘粘作用形成压力来止血并通过吸水层的吸水作用来吸收渗出物以保持伤口相对干燥,促进伤口愈合。
传统创可贴的透气性不佳,在使用过程中很容易造成葡萄球菌、破伤风杆菌等厌氧细菌的繁殖,从而造成了创面的难以愈合、化脓、结痂,影响了细胞的再生和创面的愈合。湿润性愈合理论提出后,人们越来越多的倾向使用液体敷料或水凝胶敷料等符合湿润性愈合理论的新型敷料。湿润性敷料不仅可以使细胞保持活力,使其释放生长因子,同时保持细胞与愈合组织之间的接触,调节或刺激它们的增殖。湿润性敷料可减少患者休息、走路和换药期间的疼痛。同时,湿润环境可以快速有地递送任何添加的抗菌剂,从而防止伤口被感染。现在认为产生和维持湿润环境的敷料为伤口愈合提供了最佳条件。创可贴因其快速的止血和护创功能而受到不同人群的欢迎,在未来的一段时间内,创可贴仍然将是人们外出、居家和工作必备的药械。 因而如何改进创可贴生产工艺,使其在保留原有优势的同时,让伤口处于一种湿润性的愈合环境将是未来的研究热点。
发明内容
本发明的目的在于提供一种含中药成分的抗菌止血创可贴及其制备方法。该方法制备的创可贴可以用于皮肤创伤较为表浅,伤口不宽、出血不多且不用缝合的伤口,以用来止血、止痛和消淤。
本发明提供的含中药成分的抗菌止血创可贴的制备方法,其特征在于,包括以下制备步骤:
(1)在称量实验室通过分析天平准确称量所需的三七、白芨和牡蛎壳粉末,精确到小数点后两位;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成模;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过辐照灭菌或者环氧乙烷灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
本发明所用黏性背衬是由医用级纯壳聚糖纤维水刺无纺布制成的并涂以低过敏的医用压敏胶;所用药物层包含三七、白芨和牡蛎壳粉末等成分,通过粉末压制法制备而成的薄膜;所用药液由以下质量百分含量的成分组成:三七30~40%、白芨30~40%和牡蛎壳粉末20~40%,三者都是传统中药材,所用壳聚糖止血层为水溶性壳聚糖纤维,遇水后可形成胶装物质,所用可剥离层为格拉辛纸、CCK纸或PET膜。
本发明与伤口直接接触的为中药层,其所含的三七和白芨都是中医中传统的止血药物,三七具有散瘀止血、消肿定痛的作用,白芨具有收敛止血、消肿生肌的作用,牡蛎壳粉含有动物体内铜、镁、钾、钼、磷、锰、铁、锌等多种必需的微量元素和多种氨基酸等营养成分,为伤口愈合提供了必要的营养物质。壳聚糖止血层为水溶性壳聚糖,相关文献都表明壳聚糖具有良好的抗菌性。该止血层可以瞬间吸收伤口渗出液或血液,溶解后成凝胶状,为伤口创造一个湿润的环境,从而促进伤口的愈合;其形成的凝胶将伤口与外界环境中的微生物隔绝,从而避免伤口感染的发生;其吸液溶解后具有一定的粘性,可吸附和凝结在伤口处,以达到快速止血的目的;其可以减小伤口疤痕,修复皮肤组织;其不会与伤口发生粘连,减少患者换药时的痛苦。所用黏性背衬是医用级壳聚糖无纺布,长期使用也不会造成伤口及其周围的皮肤发白和***,同时壳聚糖无纺布是生物材料可以大大减少过敏现象的发生。
附图说明
图1是创可贴生产流程图;图2是创可贴产品结构图。
具体实施方式
本发明揭示了一种含中药成分的抗菌止血创可贴,其制备方法的操作步骤如下:
(1)在称量实验室通过分析天平准确称量所需的三七、白芨和牡蛎壳粉末,精确到小数点后两位;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成模;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过辐照灭菌或者环氧乙烷灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
实施例1
(1)在称量实验室通过分析天平准确称量40.00g三七、40.00g白芨和20.00g牡蛎壳粉末;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成0.15mm的药物薄膜;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过辐照灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
实施例2
(1)在称量实验室通过分析天平准确称量30.00g三七、30.00g白芨和40.00g牡蛎壳粉末;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成0.15mm的药物薄膜;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过辐照灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
实施例3
(1)在称量实验室通过分析天平准确称量35.00g三七、35.00g白芨和30.00g牡蛎壳粉末;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成0.15mm的药物薄膜;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过环氧乙烷灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
实施例4
(1)在称量实验室通过分析天平准确称量32.00g三七、32.00g白芨和36.00g牡蛎壳粉末;
(2)将称量好的粉末混合均匀,然后通过粉末压制法挤压成0.15mm的药物薄膜;
(3)将粘性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求粘合,药物层和壳聚糖无纺布层位于粘性背衬的中间,然后将可剥离层附于粘性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的粘性背衬上下密封,使每一片创可贴都单独密封好;
(4)通过环氧乙烷灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
创可贴性质检测
我们对实施例1至实施例4所制备的创可贴分别进行细胞毒性实验(依据GB/T142332-2005第八章的检测方法)、刺激性和致敏性实验(依据GB/T16886.10-2017的检测方法)、皮内反应(依据GB/T16886.10-2017的检测方法)、全身急性毒性实验(依据GB/T16886.11-2011的检测方法)、重金属含量检测(依据中国药典2015版 0821重金属检查法的检测方法)。根据姚建磊等人(姚建磊,气相色谱-质谱法测定乙二醇二缩水甘油醚中环氧氯丙烷的残留量,理化检验-化学分册,2018年第54卷)报道的方法来检测实施例3和实施例4中环氧氯丙烷的残留量检测结果如表1所示。
表1创可贴生物性质检测实验结果
本发明实施例1至实施例4的相关实验结果还表明该抗菌创可贴无细胞毒性、生物相容性好、无刺激性和过敏性、对人体无害,符合医疗卫生用品的检测标准。该创可贴的杀菌作用主要与创可贴所含壳聚糖成分有关,同时,该创可贴含有的三七和白芨等中药粉末也促进了伤口的愈合。
创可贴愈合实验
愈合实验应该使用健康的、5~6周龄的C57BL/6雄性小鼠,应使小鼠先适应饲养环境并按照ISO10993-2的规定饲养。对于实施例1至4的创可贴进行愈合实验,具体实验步骤如下:取25只C57BL/6雄性小鼠,随机分成五组,编号A、B、C、D和E,适应性喂养3到5天后,进行实验。将小鼠分别装入尾静脉注射固定器中,在其尾部切出深浅、大小差不多的伤口,A到D组分别使用实施例1到实施例4的创可贴,E组不做任何处理使其自然愈合作为对照组,正常饲养,每隔24h换取新的创可贴,每隔6h观察并记录伤口愈合情况,18h之后,经过创可贴处理过的小鼠伤口分别开始愈合,而空白对照小鼠在72h之后才开始愈合;96h之后,经过创可贴处理的小鼠创口基本完全愈合且在愈合过程中未出现感染现象,未经处理的伤口需要168h才能愈合,表明本发明的创可贴可以有效促进伤口愈合和防止伤口感染,这可能源于壳聚糖的抗菌活性,三七和白芨的消炎、止血活性。
以上实施例仅用以说明本发明的技术方案, 并非对本发明的技术范围作任何限制,对于本领域的普通技术人员来说,依然可以对前述实施例所记载的技术方案进行细微修改,或者对其中部分技术特征进行等同替换而这些修改或替换,并不使相应技术方案的本质脱离本发明所要求保护的技术方案的精神和范围。
Claims (3)
1.一种含中药成分的抗菌止血创可贴,其特征在于,该创可贴由黏性背衬、药物层、壳聚糖止血层和可剥离层组成,其顺序依次为黏性背衬、壳聚糖止血层、药物层和可剥离层,黏性背衬是由医用级纯壳聚糖纤维水刺无纺布制成的并涂以低过敏的医用压敏胶,药物层是采用粉末压制法制成的薄膜,与伤口直接接触,
所用药物层由以下质量百分含量的成分组成:三七30~40%、白芨30~40%和牡蛎壳粉末20~40%,三者都是传统中药材,壳聚糖止血层为水溶性壳聚糖纤维,遇水后可形成胶状物质。
2.根据权利要求1所述的含中药成分的抗菌止血创可贴,其特征在于,所用可剥离层为格拉辛纸、CCK纸或PET膜。
3.根据权利要求1所述的含中药成分的抗菌止血创可贴,其特征在于,其制备方法的操作步骤如下:在称量实验室通过分析天平准确称量所需的三七、白芨和牡蛎壳粉末,精确到小数点后两位;将称量好的粉末混合均匀,然后通过粉末压制法挤压成膜;将黏性背衬按照尺寸要求分切,与分切好的药物层和壳聚糖止血层按尺寸规格要求黏合,药物层和壳聚糖无纺布层位于黏性背衬的中间,然后将可剥离层附于黏性背衬胶面上,冷封彩纸与白纸分别从附着好可剥离层的黏性背衬上下密封,使每一片创可贴都单独密封好,通过辐照灭菌或者环氧乙烷灭菌,灭菌完成即可获得相应的含中药成分的抗菌止血创可贴。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010971352.7A CN111956859B (zh) | 2020-09-16 | 2020-09-16 | 一种含中药成分的抗菌止血创可贴及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010971352.7A CN111956859B (zh) | 2020-09-16 | 2020-09-16 | 一种含中药成分的抗菌止血创可贴及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111956859A CN111956859A (zh) | 2020-11-20 |
CN111956859B true CN111956859B (zh) | 2022-11-11 |
Family
ID=73393404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010971352.7A Active CN111956859B (zh) | 2020-09-16 | 2020-09-16 | 一种含中药成分的抗菌止血创可贴及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111956859B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010096018A (ko) * | 2000-04-17 | 2001-11-07 | 정용식 | 키토산 섬유 부직포 및 그 제조방법 |
CN103143050A (zh) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | 羧甲基壳聚糖创可贴及其制备方法 |
CN203042642U (zh) * | 2013-01-17 | 2013-07-10 | 喻宁哲 | 一种水溶性壳聚糖创可贴 |
CN104208743A (zh) * | 2014-08-18 | 2014-12-17 | 朱世真 | 一种止血镇痛敷料 |
CN105477677A (zh) * | 2015-08-12 | 2016-04-13 | 孙一然 | 辣木抗菌创可贴 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8703176B2 (en) * | 2004-02-23 | 2014-04-22 | Loma Linda University Medical Center | Hemostatic agent for topical and internal use |
-
2020
- 2020-09-16 CN CN202010971352.7A patent/CN111956859B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010096018A (ko) * | 2000-04-17 | 2001-11-07 | 정용식 | 키토산 섬유 부직포 및 그 제조방법 |
CN203042642U (zh) * | 2013-01-17 | 2013-07-10 | 喻宁哲 | 一种水溶性壳聚糖创可贴 |
CN103143050A (zh) * | 2013-03-08 | 2013-06-12 | 苏州艾美医疗用品有限公司 | 羧甲基壳聚糖创可贴及其制备方法 |
CN104208743A (zh) * | 2014-08-18 | 2014-12-17 | 朱世真 | 一种止血镇痛敷料 |
CN105477677A (zh) * | 2015-08-12 | 2016-04-13 | 孙一然 | 辣木抗菌创可贴 |
Also Published As
Publication number | Publication date |
---|---|
CN111956859A (zh) | 2020-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Molan | Re-introducing honey in the management of wounds and ulcers-theory and practice | |
CN103341203B (zh) | 一种药用敷料、药用敷料制作方法及敷料贴的制作方法 | |
CN103446618A (zh) | 一种抗菌水凝胶伤口被覆膜及采用该被覆膜制成的创面贴 | |
CN110935056A (zh) | 一种高吸湿性藻酸盐敷料制备方法 | |
CN111012945B (zh) | 一种防水中药液体创可贴及其制备方法 | |
CN107412842B (zh) | 一种带凝血酶的海藻酸盐伤口敷贴的制备方法 | |
CN201676083U (zh) | 一种治疗烧烫伤、创伤的活性银离子抗菌敷料 | |
CN111956859B (zh) | 一种含中药成分的抗菌止血创可贴及其制备方法 | |
CN112076339B (zh) | 一种含氧化锌纳米颗粒的抗菌创可贴及其制备方法 | |
CN109432483B (zh) | 一种加速创面愈合的医用敷料及其制备方法和应用 | |
CN101757347B (zh) | 断血创可贴及其制备方法 | |
CN107595819B (zh) | 一种纳米金刚石改性液体创可贴及其制备方法 | |
CN212756124U (zh) | 一种癌性伤口专用敷料 | |
CN110916900A (zh) | 一种水凝胶医用敷料及其制备方法 | |
CN208339669U (zh) | 一种促进伤口快速愈合的医用敷料 | |
CN202458908U (zh) | 新型创可贴 | |
CN202191515U (zh) | 一种复合海绵敷料 | |
TW201728344A (zh) | 皮膚敷料添加物及其應用 | |
Foutsizoglou | A practical guide to the most commonly used dressings in wound care | |
CN219614204U (zh) | 一种壳聚糖缓释微球基创可贴 | |
CN203042644U (zh) | 一种芦荟伤口贴 | |
CN218792766U (zh) | 一种壳聚糖杀菌敷料贴 | |
CN209884516U (zh) | 一种透明海藻酸盐伤口愈合贴 | |
CN215020452U (zh) | 一种切口敷料 | |
CN220860391U (zh) | 一种用于创面愈合的无菌生物护创膜 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |