CN111920880A - Medicinal moxibustion for warming and invigorating kidney yang and preparation method thereof - Google Patents

Medicinal moxibustion for warming and invigorating kidney yang and preparation method thereof Download PDF

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CN111920880A
CN111920880A CN202010818605.7A CN202010818605A CN111920880A CN 111920880 A CN111920880 A CN 111920880A CN 202010818605 A CN202010818605 A CN 202010818605A CN 111920880 A CN111920880 A CN 111920880A
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parts
medicament
water
weight
moxibustion
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张爱林
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China Health Management Hangzhou Co ltd
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China Health Management Hangzhou Co ltd
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Abstract

The invention discloses a medicinal moxibustion for warming and recuperating kidney yang and a preparation method thereof, and relates to the technical field of medical treatment and health care, the medicinal moxibustion comprises a heating bag and a medicament patch, the medicament patch comprises a medicament bag and a medicament, the medicament comprises a medicament composition I and a medicament composition II, and the medicament composition I comprises the following components in parts by weight: 10-12 parts of curculigo orchioides, 12-16 parts of epimedium, 8-12 parts of morinda officinalis, 14-16 parts of longhairy antenoron herb and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 12-14 parts of astragalus membranaceus, 8-12 parts of prepared rehmannia root, 5-7 parts of folium artemisiae argyi, 3-5 parts of peppermint essential oil and 18-22 parts of microemulsion matrix; the medicinal moxibustion provided by the scheme has the advantages that the components in the formula have synergistic effects, and the medicinal moxibustion is pertinently matched with acupuncture point treatment, and has the effects of improving symptoms such as soreness and weakness of waist and knees, weak tendons and bones, mental fatigue and hypodynamia, sexual hypofunction, cold hands and feet, aversion to cold and wind, body edema, female enuresis and the like.

Description

Medicinal moxibustion for warming and invigorating kidney yang and preparation method thereof
Technical Field
The invention relates to the technical field of health care, in particular to a medicinal moxibustion for warming and invigorating kidney yang and a preparation method thereof.
Background
Kidney deficiency refers to the deficiency of kidney essence, qi, yin and yang. There are many kinds of kidney deficiency, and the most common of them are kidney yin deficiency and kidney yang deficiency. Kidney yang deficiency is manifested by soreness of the waist and knees, weakness of bones and muscles, lassitude, asthenia, heaviness of body, hyposexuality, sexual hypofunction, cold limbs, aversion to cold, diarrhea, and edema. In addition, enuresis occurs due to kidney yang deficiency in women. Modern science proves that when people have kidney deficiency, the deficiency of both kidney yin and kidney yang can cause the reduction of the immunity of people. There is much evidence that when kidney deficiency occurs, the immune capacity of the kidney is reduced, the microcirculation system of the kidney is also blocked, and the kidney channels are obstructed. Therefore, the treatment of kidney deficiency should be combined with prevention and treatment.
Traditional moxibustion, such as moxa sticks and moxa sticks, is widely used for moxibustion to treat various diseases. However, in clinical use, a professional doctor is required to operate, and in the implementation process, the doctor is required to skillfully master the names, the positions, the moxibustion application sequence and the moxibustion application time of related acupuncture points of different diseases, particularly the moxibustion time is not easy to control, the operation is often inaccurate, the moxibustion effect is affected, and the treatment course is prolonged; after the moxa-moxibustion got into the family, in self-service use, numerous patients lacked professional knowledge and skill, not only the pertinence is not strong, leads to the curative effect relatively poor, and misoperation easily moreover, this can lead to the side effect, brings great loss for people.
Recently, drugs are added into moxibustion, moxibustion therapy is realized by means of moxibustion therapy process, and the defects of weak pertinence, simple drug formula, unreasonable compatibility and unobvious improvement of curative effect exist.
In conclusion, a mild medicinal moxibustion for warming and invigorating kidney yang with more stable curative effect needs to be researched.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides medicinal moxibustion for warming and recuperating kidney yang and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the drug moxibustion for warming and recuperating kidney yang comprises a heating bag and a drug patch, wherein the drug patch comprises a drug bag and a drug, the drug comprises a drug composition I and a drug composition II, and the raw materials of the drug composition I comprise the following components in parts by weight: 10-12 parts of curculigo orchioides, 12-16 parts of epimedium, 8-12 parts of morinda officinalis, 14-16 parts of longhairy antenoron herb and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 12-14 parts of astragalus membranaceus, 8-12 parts of prepared rehmannia root, 5-7 parts of folium artemisiae argyi, 3-5 parts of peppermint essential oil and 18-22 parts of microemulsion matrix.
Preferably, the ethosome matrix comprises 8-12 parts by weight of isopropanol, 8-12 parts by weight of ethanol, 4-5 parts by weight of hydroxypropyl methyl cellulose, 8-10 parts by weight of lecithin, 5-7 parts by weight of cholesterol, 6-8 parts by weight of hyaluronic acid, 10-14 parts by weight of glycerol and 14-16 parts by weight of sodium alginate.
Preferably, the microemulsion matrix comprises, by weight, 10-12 parts of oleic acid, 5-9 parts of propylene glycol, 4-8 parts of xanthan gum, 10-20 parts of polyoxyethylene castor oil, 8-10 parts of isopropyl myristate, 6-8 parts of citric acid and 16-20 parts of water.
Preferably, the heating bag comprises a material bag and a heating agent, wherein the heating agent comprises, by weight, 40-80 parts of iron powder, 10-30 parts of a water gel, 4-10 parts of an auxiliary dispersing agent, 10-20 parts of a catalyst and 5-10 parts of a coupling agent.
Preferably, the condensed hydrocolloid comprises the following components in parts by weight: 1-2 parts of high-molecular water-absorbing resin, 2-4 parts of salt and 10-20 parts of water.
Preferably, the high molecular water-absorbing resin is polyacrylic acid water-absorbing resin or PVA resin.
Preferably, the catalyst is a carbon compound, and the auxiliary dispersant is one or more of vermiculite, wood chips, floating beads and diatomite. The choice of catalyst can be adapted according to the prior art.
Preferably, the coupling agent comprises the following components in parts by weight: 1-2 parts of propylene glycol, 10-30 parts of vaseline, 10-20 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 10-15 parts of lanolin.
Preferably, the heating bag and the medicament paste are mutually adhered; the medicament bag and the material bag are sewn by two layers of thin cloth, wherein one layer is composed of laminating non-woven fabric, and the other layer is composed of breathable film; one surface of the material bag, which is formed by the laminated non-woven fabric, is bonded with one surface of the medicament bag, which is formed by the laminated non-woven fabric; the medicament bag is equipped with the one side of ventilative film and sets up pressure-sensitive adhesive to the configuration is from type paper, the material area is equipped with the one side of ventilative film all around and is equipped with pressure-sensitive adhesive, and disposes from type paper.
Preferably, the preparation method of the pharmaceutical composition I comprises the following steps:
1) placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, and pulverizing; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, and adding deionized water for extraction; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the ultrasonic extraction liquid of the nano traditional Chinese medicine into a vacuum high-speed dispersion tank, sequentially adding isopropanol, ethanol, hydroxypropyl methylcellulose, lecithin, cholesterol and hyaluronic acid, and uniformly dispersing to obtain a nano traditional Chinese medicine ethosome;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding sodium alginate, glycerol and deionized water, and uniformly dispersing to obtain a medicament composition I.
Preferably, in the pulverizing process in the step 1) of preparing the pharmaceutical composition I, the medicine feeding speed is set to be 60 g/min, the pulverizing granularity is adjusted to be 30-40nm, and the traditional Chinese medicine is finely pulverized; in the extraction process, the dosage of deionized water is 6-8 times of the weight of the raw material medicine, and the extraction time is 30-40 min. The above range can be adaptively modified according to the weight of the Chinese medicinal materials to be treated, for example, the treatment time can be prolonged when the amount of the Chinese medicinal materials is large.
Preferably, in the step 2) of preparing the pharmaceutical composition I, the rotation speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min. In the step 3) of preparing the pharmaceutical composition I, the rotation speed of the dispersion tank was adjusted to 1400 rpm, and the dispersion was carried out at a high speed for 20 minutes. The specific parameters can be adaptively adjusted according to actual conditions. Deionized water is added in the step 3), and the specific content can be adjusted adaptively according to the prior art of high-speed dispersion.
Preferably, the preparation method of the pharmaceutical composition II comprises the following steps:
1) pulverizing radix astragali, radix rehmanniae Preparata and folium Artemisiae Argyi into fine powder to obtain medicinal mixture;
2) oil phase: mixing the medicine mixture, the peppermint essential oil, the oleic acid, the isopropyl myristate and the polyoxyethylene castor oil in an ice-water bath, and uniformly stirring for 20-50 min to form an oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in an ice-water bath for 10-50 min to form a water phase;
4) microemulsion polymerization: and mixing the oil phase and the water phase, heating to 70-90 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at a speed of 400-800 r/min, carrying out microemulsion polymerization for 3-7 h, and cooling to room temperature to obtain a medicament composition II.
Preferably, the preparation method of the medicinal moxibustion for warming and recuperating kidney yang comprises the following steps:
1) preparation of the medicament patch: respectively preparing a medicament composition I and a medicament composition II, then uniformly mixing, and putting into a medicament bag to prepare a medicament patch;
2) preparing a heating bag:
A. weighing the macromolecular water-absorbing resin, the salt and the water according to the proportion, and uniformly mixing to obtain a water gel;
B. weighing propylene glycol, vaseline, monoglyceride, polyvinylpyrrolidone and lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing iron powder, water gel, auxiliary dispersant, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3) and (3) mutually bonding the medicament patch prepared in the step 1) and the heating bag prepared in the step 2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
The rhizoma Curculiginis is dried rhizome of rhizoma Curculiginis of Amaryllidaceae. The chemical components comprise tannin 4%, fat 1%, resin, starch, etc. Pungent, warm and toxic in nature and flavor. It enters kidney and liver meridians. The functional indications are as follows: warming kidney yang, strengthening tendons and bones. It is indicated for impotence, seminal cold, urinary incontinence, metrorrhagia, psychroalgia of heart and abdomen, cold arthralgia of waist and feet, carbuncle and abscess, scrofula, yang deficiency and cold diarrhea.
Xianling is pungent, sweet and warm in flavor. It enters liver and kidney meridians. The functional indications are as follows: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. Can be used for treating sexual impotence, spermatorrhea, tendons and bones flaccidity, rheumatalgia, numbness and contracture; climacteric hypertension.
The radix Morindae officinalis is dried root of Morinda officinalis of Rubiaceae. Sweet in nature and flavor, pungent and slightly warm. It enters kidney and liver meridians. The functional indications are as follows: tonify kidney yang, strengthen tendons and bones, dispel wind-damp. Can be used for treating sexual impotence, spermatorrhea, infertility due to cold womb, menoxenia, cold pain of lower abdomen, rheumatic arthralgia, and flaccidity of tendons and bones.
Herba Lysimachiae Christinae is dry whole plant of primula family plant of Lysimachia christinae Hance. Sweet, salty and slightly cold in nature and taste. It enters liver, gallbladder, kidney and bladder meridians. The functional indications are as follows: clear damp-heat, treat stranguria and relieve swelling. Can be used for treating heat stranguria, stranguria caused by sand, dysuria, jaundice, dark urine, carbuncle, furuncle, and snake bite; calculus of liver and gallbladder, and lithangiuria.
Radix astragali is dried root of Astragalus membranaceus bge or Astragalus membranaceus bge of Leguminosae. Sweet in nature and taste, warm. It enters lung and spleen meridians. The functional indications are as follows: tonify qi, strengthen superficies, induce diuresis, expel pus, heal wound and promote tissue regeneration. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes.
The prepared rehmannia root is a processed product of rehmannia root. Sweet in nature and taste, slightly warm. It enters liver and kidney meridians. The functional indications are as follows: to nourish yin, enrich blood, replenish essence and replenish marrow. Can be used for treating deficiency of liver-yin and kidney-yin, soreness of waist and knees, hectic fever, night sweat, nocturnal emission, internal heat, diabetes, blood deficiency, sallow complexion, cardiopalmus, severe palpitation, menoxenia, metrorrhagia, metrostaxis, hemorrhage, giddiness, tinnitus, and early white beard and hair.
The folium Artemisiae Argyi is dried leaf of Artemisia argyi of Compositae. Pungent, bitter and warm in nature; has little toxicity. It enters liver, spleen and kidney meridians. The functional indications are as follows: dispel cold to alleviate pain, warm meridians to stop bleeding. Can be used for treating lower abdomen psychroalgia, irregular menstruation, infertility due to cold womb, hematemesis, epistaxis, metrorrhagia, metrostaxis, and pregnancy bleeding; it can be used for treating skin pruritus. Vinegar moxa charcoal warms the channels to stop bleeding. Can be used for treating hemorrhage due to deficiency cold.
The peppermint essential oil contains pulegone. Is cool in nature. The functional indications are as follows: calming the heart and tranquilizing the mind; induce diuresis to clear heat. Major palpitations; insomnia; edema; cold with fever; conjunctival congestion with swelling and pain; sores and ulcers with pyogenic infections.
Analyzed from the chemical beneficial components of the traditional Chinese medicine, the curculigo orchioides, the epimedium, the morinda officinalis, the desmodium, the astragalus mongholicus, the prepared rehmannia root and the folium artemisiae argyi belong to warm-tonifying traditional Chinese medicines, and have the effects of reinforcing qi and warming and tonifying kidney yang. The traditional Chinese medicinal materials of the scheme have reasonable compatibility of monarch, minister, assistant and guide, obvious effect, low cost and obvious effect, promote blood circulation, warm and tonify kidney yang, and are matched with acupuncture point-specific moxibustion.
In addition, isopropanol, ethanol, hydroxypropyl methylcellulose, hyaluronic acid and a microemulsion matrix are added, and the drug is carried by the ethosome and the microemulsion, so that the absorption efficiency of the drug is improved. The transdermal drug delivery system is an effective administration mode for absorbing therapeutic drugs through the skin, and the therapeutic drugs are applied to the skin, penetrate through the stratum corneum of the skin, diffuse into each layer of the skin, and then are absorbed into the systemic circulation by the capillaries in the skin tissue. The whole preparation process of the ethosome can be finished at normal temperature, can encapsulate the medicament, and can achieve higher encapsulation efficiency. The ethosome containing the traditional Chinese medicine has the characteristics of deformability, good fluidity, small skin irritation, good transdermal effect, large skin retention, capability of transferring the medicine in cells and the like. The microemulsion containing the drug is used as a carrier of a transdermal drug delivery preparation, and the transdermal effect of the drug is remarkable. The mechanism is as follows: 1. increasing the solubility of the drug; 2. altering the structure of the stratum corneum; 3. passing through the hair follicle in an intact structure; 4. the medicine can penetrate skin after being precipitated from microemulsion.
Compared with the prior art, the invention provides a medicinal moxibustion for warming and recuperating kidney yang and a preparation method thereof, and the medicinal moxibustion has the following beneficial effects:
1. the medicinal moxibustion for warming and invigorating kidney yang has obvious curative effects on symptoms such as soreness and weakness of waist and knees, weak bones and muscles, mental fatigue and hypodynamia, hyposexuality, sexual dysfunction, cold hands and feet, intolerance of cold and wind, body edema, female enuresis and the like caused by kidney yang deficiency, and symptoms such as soreness and weakness of waist and knees, weakness of two legs, vexation and testiness, dizziness and tinnitus, emaciation, insomnia and dreaminess, red cheeks and tidal fever, night sweat and dry throat, male impotence or stiff yang, hypersexuality, spermatorrhea and premature ejaculation, female hypomenorrhea, amenorrhea and the like caused by kidney yin deficiency. The traditional Chinese medicine strictly follows the theory of traditional Chinese medicine, focuses on the balance of yin and yang, can be used for a long time, and does not have the symptoms of dry mouth and tongue, epistaxis, constipation and the like caused by hyperactivity of yang qi, damage of yin fluid and endogenous heat.
2. The alcohol liposome contains ethanol in liposome, phospholipid is the main chemical component in the bilayer structure of the alcohol liposome, and the alcohol liposome contains relatively high volume fraction of ethanol, i.e. high concentration of low molecular weight alcohol is added on the basis of the liposome. The existence of ethanol enhances the flexibility of the liposome, and after the low molecular weight alcohol is added, the ethanol replaces the moisture near the head group of the lipid bilayer, thereby increasing and improving the mobility of the bilayer, and the ethanol molecule also changes the close arrangement of phospholipid molecules between skin cutin layers, promotes the drug to permeate skin barriers, and improves the transdermal absorption effect.
The ethosome can be fused with the cell membrane of the organism, and the wrapped content is transferred into the cell membrane; ethosomes are easily deformed to penetrate the various pores of the skin barrier, such as the phospholipid layer between the cuticles and the pilosebaceous glands, etc.; the ethosome is a zwitterionic surfactant, has oleophilic and hydrophilic properties, and can effectively encapsulate various compounds (fat-soluble and water-soluble molecules including protein polypeptide molecules) to penetrate to reach the deep layer of the skin. Therefore, it can be said that the flexible liposome and the ethosome have increased membrane flexibility, have increased deformability when crossing the skin barrier, are more suitable for crossing the keratinocyte gap, and are ideal carriers for carrying macromolecules.
3. The microemulsion has the characteristics of low viscosity, isotropy and thermodynamic stability, and is a transparent or semitransparent oil-water mixed system. The microemulsion can increase the solubility of the drug, increase the transdermal rate of the drug, improve the stability of the drug, prolong the action time of the drug, maintain constant blood concentration, and has simple preparation process and the like.
4. According to the scheme, two methods of the ethosome and the microemulsion for promoting the skin to absorb the drug are adopted, so that the absorption efficiency of the drug is further improved, the effect is fast, the pertinence is strong, and the treatment effect is good.
5. The coupling agent is creatively added into the gel heating agent, has the functions of coupling, conduction and permeation, so that the product is more closely contacted with the skin, the energy is efficiently and uniformly absorbed by the skin and tissues, the synergistic effects of coupling, conduction and permeation are achieved, the treatment speed is accelerated, the effect is quick, and the defects that the patch on the market generally adopts the traditional process and the simple skin permeation and absorption principle are overcome.
6. The heating bag can locally heat the affected part, dilate capillary vessels, and accelerate blood circulation and tissue metabolism; the couplant is applied, so that energy is efficiently and uniformly absorbed by skin and tissues, and the couplant has the effects of coupling, conduction and permeation; acting on skin and subcutaneous tissue, promoting molecular movement in cells, accelerating metabolism, promoting drug absorption, rapidly transporting to affected part, and improving rapid therapeutic effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1:
a medicinal moxibustion for warming and recuperating kidney yang and its preparation method comprises the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 10 parts of curculigo orchioides, 12 parts of epimedium, 8 parts of morinda officinalis, 14 parts of longhairy antenoron herb and 16 parts of ethosome matrix according to the proportion; placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, pulverizing at a feed speed of 60 g/min, and adjusting the pulverizing particle size to 30 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 6 times of the weight of the raw material medicines, and the extraction time is 30 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 8 parts of isopropanol, 8 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 8 parts of lecithin, 5 parts of cholesterol and 6 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 10 parts of glycerol, 14 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 12 parts of astragalus, 8 parts of prepared rehmannia root, 5 parts of folium artemisiae argyi, 3 parts of peppermint essential oil and 18 parts of microemulsion matrix according to the proportion, and crushing the astragalus, the prepared rehmannia root and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 10 parts of oleic acid, 5 parts of propylene glycol, 4 parts of xanthan gum, 10 parts of polyoxyethylene castor oil, 8 parts of isopropyl myristate, 6 parts of citric acid and 16 parts of water according to a ratio; mixing the medicinal mixture, peppermint essential oil, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 20min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 10min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 70 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at the speed of 400 r/min, carrying out microemulsion polymerization for 3h, and then cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1 part of high-molecular water-absorbing resin, 2 parts of salt and 10 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1 part of propylene glycol, 10 parts of vaseline, 10 parts of monoglyceride, 0.5 part of polyvinylpyrrolidone and 10 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 40 parts of iron powder, 10 parts of water gel, 10 parts of auxiliary dispersing agent, 10 parts of catalyst and 5 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
Example 2:
a medicinal moxibustion for warming and recuperating kidney yang and its preparation method comprises the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 12 parts of curculigo orchioides, 16 parts of epimedium herb, 12 parts of morinda officinalis, 16 parts of longhairy antenoron herb and 20 parts of ethosome matrix according to the proportion; placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, pulverizing at a feed speed of 60 g/min, and adjusting the pulverizing particle size to 40 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 8 times of the weight of the raw material medicines, and the extraction time is 40 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 12 parts of isopropanol, 12 parts of ethanol, 5 parts of hydroxypropyl methyl cellulose, 10 parts of lecithin, 7 parts of cholesterol and 8 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 14 parts of glycerol, 16 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 14 parts of astragalus, 12 parts of prepared rehmannia root, 7 parts of folium artemisiae argyi, 5 parts of peppermint essential oil and 22 parts of microemulsion matrix according to the proportion, and crushing the astragalus, the prepared rehmannia root and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 12 parts of oleic acid, 9 parts of propylene glycol, 8 parts of xanthan gum, 20 parts of polyoxyethylene castor oil, 10 parts of isopropyl myristate, 8 parts of citric acid and 20 parts of water according to a ratio; mixing the medicinal mixture, peppermint essential oil, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 50min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 50min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 90 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at the speed of 800 r/min, performing microemulsion polymerization for 7h, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 2 parts of high-molecular water-absorbing resin, 4 parts of salt and 20 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 2 parts of propylene glycol, 30 parts of vaseline, 20 parts of monoglyceride, 1 part of polyvinylpyrrolidone and 15 parts of lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing 80 parts of iron powder, 30 parts of water gel, 30 parts of auxiliary dispersant, 20 parts of catalyst and 10 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
Example 3:
a medicinal moxibustion for warming and recuperating kidney yang and its preparation method comprises the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 11 parts of curculigo orchioides, 14 parts of epimedium herb, 10 parts of morinda officinalis, 15 parts of longhairy antenoron herb and 18 parts of ethosome matrix according to the mixture ratio; placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, pulverizing at a feed speed of 60 g/min, and adjusting the particle size to 35 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 7 times of the weight of the raw material medicines, and the extraction time is 35 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 10 parts of isopropanol, 10 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 9 parts of lecithin, 6 parts of cholesterol and 9 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 12 parts of glycerol, 15 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 13 parts of astragalus, 10 parts of prepared rehmannia root, 6 parts of folium artemisiae argyi, 4 parts of peppermint essential oil and 20 parts of microemulsion matrix according to the proportion, and crushing the astragalus, the prepared rehmannia root and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 11 parts of oleic acid, 7 parts of propylene glycol, 6 parts of xanthan gum, 15 parts of polyoxyethylene castor oil, 9 parts of isopropyl myristate, 7 parts of citric acid and 18 parts of water according to a ratio; mixing the medicinal mixture, peppermint essential oil, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 35min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 30min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 80 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at a speed of 600 revolutions per minute, performing microemulsion polymerization for 5 hours, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.5 parts of high molecular water-absorbing resin, 3 parts of salt and 15 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.5 parts of propylene glycol, 20 parts of vaseline, 15 parts of monoglyceride, 0.75 part of polyvinylpyrrolidone and 12.5 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 60 parts of iron powder, 20 parts of water gel, 20 parts of auxiliary dispersing agent, 15 parts of catalyst and 7.5 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
Example 4:
a medicinal moxibustion for warming and recuperating kidney yang and its preparation method comprises the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 10 parts of curculigo orchioides, 16 parts of epimedium herb, 8 parts of morinda officinalis, 16 parts of longhairy antenoron herb and 18 parts of ethosome matrix according to the proportion; placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, pulverizing at a feed speed of 60 g/min, and adjusting the pulverizing particle size to 33 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 6 times of the weight of the raw material medicines, and the extraction time is 35 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 9 parts of isopropanol, 11 parts of ethanol, 4 parts of hydroxypropyl methyl cellulose, 10 parts of lecithin, 5 parts of cholesterol and 8 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 12 parts of glycerol, 15 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 12 parts of astragalus, 12 parts of prepared rehmannia root, 5 parts of folium artemisiae argyi, 3 parts of peppermint essential oil and 20 parts of microemulsion matrix according to the proportion, and crushing the astragalus, the prepared rehmannia root and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 11 parts of oleic acid, 6 parts of propylene glycol, 5 parts of xanthan gum, 12 parts of polyoxyethylene castor oil, 8 parts of isopropyl myristate, 6 parts of citric acid and 18 parts of water according to a ratio; mixing the medicinal mixture, peppermint essential oil, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 30min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 20min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 75 ℃ under an oxygen-free condition, performing ultrasonic dispersion, mechanically stirring at the speed of 500 r/min, performing microemulsion polymerization for 4 hours, and cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.2 parts of high-molecular water-absorbing resin, 2.3 parts of salt and 12 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.2 parts of propylene glycol, 15 parts of vaseline, 12 parts of monoglyceride, 0.7 part of polyvinylpyrrolidone and 12 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 50 parts of iron powder, 16 parts of water gel, 15 parts of auxiliary dispersant, 13 parts of catalyst and 6 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
Example 5:
a medicinal moxibustion for warming and recuperating kidney yang and its preparation method comprises the following steps:
1. preparation of the medicament patch:
the preparation method of the A medicament composition I comprises the following steps:
1) weighing 12 parts of curculigo orchioides, 12 parts of epimedium herb, 12 parts of morinda officinalis, 14 parts of longhairy antenoron herb and 18 parts of ethosome matrix according to the mixture ratio; placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, pulverizing at a feed speed of 60 g/min, and adjusting the pulverizing particle size to 37 nm; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, adding deionized water for extraction, wherein the dosage of the deionized water is 8 times of the weight of the raw material medicines, and the extraction time is 38 min; filtering the Chinese medicinal liquid in the ultrasonic extractor to obtain nanometer Chinese medicinal ultrasonic extractive solution;
2) placing the nano traditional Chinese medicine ultrasonic extraction liquid into a vacuum high-speed dispersion tank, sequentially adding 11 parts of isopropanol, 9 parts of ethanol, 5 parts of hydroxypropyl methyl cellulose, 8 parts of lecithin, 7 parts of cholesterol and 6 parts of hyaluronic acid, and uniformly dispersing to form a nano traditional Chinese medicine ethosome, wherein the rotating speed of the dispersion tank is 3000 r/min, and the high-speed dispersion is carried out for 15 min;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding 14 parts of glycerol, 14 parts of sodium alginate and 800 parts of deionized water, uniformly dispersing to obtain a medicament composition I, adjusting the rotating speed of the dispersion tank to 1400 revolutions per minute, and dispersing at a high speed for 20 minutes;
the preparation method of the B medicament composition II comprises the following steps:
1) weighing 14 parts of astragalus, 8 parts of prepared rehmannia root, 7 parts of folium artemisiae argyi, 3 parts of peppermint essential oil and 19 parts of microemulsion matrix according to the proportion, and crushing the astragalus, the prepared rehmannia root and the folium artemisiae argyi into fine powder to prepare a medicine mixture;
2) oil phase: weighing 12 parts of oleic acid, 5 parts of propylene glycol, 8 parts of xanthan gum, 16 parts of polyoxyethylene castor oil, 10 parts of isopropyl myristate, 6 parts of citric acid and 19 parts of water according to a ratio; mixing the medicinal mixture, peppermint essential oil, oleic acid, isopropyl myristate and polyoxyethylene castor oil in ice water bath, and stirring for 40min to obtain oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in ice water bath for 40min to obtain water phase;
4) microemulsion polymerization: mixing the oil phase and the water phase, heating to 80 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at the speed of 700 r/min, carrying out microemulsion polymerization for 6h, and then cooling to room temperature to obtain a medicament composition II;
and C, uniformly mixing the prepared medicament composition I and the prepared medicament composition II, and putting the mixture into a medicament bag to prepare the medicament patch.
2. Preparing a heating bag:
A. weighing 1.8 parts of high-molecular water-absorbing resin, 3.5 parts of salt and 18 parts of water according to the proportion, and uniformly mixing to obtain a water-gel;
B. weighing 1.7 parts of propylene glycol 27 parts of vaseline, 18 parts of monoglyceride, 0.8 part of polyvinylpyrrolidone and 13 parts of lanolin according to the proportion, and uniformly mixing to obtain a coupling agent;
C. weighing 70 parts of iron powder, 25 parts of water gel, 25 parts of auxiliary dispersant, 17 parts of catalyst and 9 parts of coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3. and (3) mutually bonding the medicament patch prepared in the step (1) and the heating bag prepared in the step (2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
Comparative example 1:
in the medicament composition I in the comparative example 1, no ethosome matrix is added, and the Chinese medicinal raw materials are simply mixed; the rest of the steps are consistent with example 1.
Comparative example 2:
the microemulsion matrix is not added in the medicament composition II in the comparative example 2, and the traditional Chinese medicine raw materials are simply mixed; the rest of the steps are consistent with example 1.
Comparative example 3:
in the medicament composition I in the comparative example 3, the ethosome matrix is not added, and the microemulsion matrix is not added in the medicament composition II, so that the Chinese medicinal raw materials are simply mixed; the rest of the steps are consistent with example 1.
The prepared moxibustion for warming and recuperating kidney yang of examples 1 to 5 and comparative examples 1 to 3 were tested, and 30 patients with symptoms were tested. The therapeutic effect judgment refers to the therapeutic effect judgment standard formulated from the clinical disease diagnosis treatment improvement standard and the traditional Chinese medicine disease diagnosis therapeutic effect standard, and the therapeutic effect judgment is carried out according to the therapeutic effect index and the clinical diagnosis result.
a) And (3) healing: after 2 treatment courses, the discomfort symptoms disappear;
b) the effect is shown: after 2 treatment courses, the discomfort symptoms are obviously relieved;
c) the method has the following advantages: after 2 treatment courses, the discomfort symptoms are relieved to a certain extent;
the results are shown in table 1 below:
Figure BDA0002633650470000131
Figure BDA0002633650470000141
referring to the above examples 1 to 5, it can be seen from the experimental data of comparative examples 1 to 3 and table 1 that the moxibustion with the composition of the present invention, which is synergistic with the components of the formulation, improves the symptoms of soreness and weakness of waist and knees, atrophy and weakness of muscles and bones, lassitude, hyposexuality, sexual dysfunction, cold limbs, aversion to cold and wind, edema of body and enuresis of women by means of the synergistic effect of the components of the formulation and the targeted combination with the acupuncture point therapy, compared with the moxibustion with the comparative examples 1 to 3, which is effective in warming and invigorating kidney yang.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (10)

1. The medicinal moxibustion for warming and recuperating kidney yang is characterized by comprising a heating bag and a medicament patch, wherein the medicament patch comprises a medicament bag and a medicament, the medicament comprises a medicament composition I and a medicament composition II, and the raw materials of the medicament composition I comprise the following components in parts by weight: 10-12 parts of curculigo orchioides, 12-16 parts of epimedium, 8-12 parts of morinda officinalis, 14-16 parts of longhairy antenoron herb and 16-20 parts of ethosome matrix; the medicament composition II comprises the following components in parts by weight: 12-14 parts of astragalus membranaceus, 8-12 parts of prepared rehmannia root, 5-7 parts of folium artemisiae argyi, 3-5 parts of peppermint essential oil and 18-22 parts of microemulsion matrix.
2. The moxibustion for warming and recuperating kidney yang as claimed in claim 1, wherein the ethosome base comprises 8-12 parts by weight of isopropanol, 8-12 parts by weight of ethanol, 4-5 parts by weight of hydroxypropyl methylcellulose, 8-10 parts by weight of lecithin, 5-7 parts by weight of cholesterol, 6-8 parts by weight of hyaluronic acid, 10-14 parts by weight of glycerol and 14-16 parts by weight of sodium alginate.
3. A medicated moxibustion for warming and recuperating kidney yang as defined in claim 1, wherein said microemulsion matrix comprises oleic acid 10-12 parts, propylene glycol 5-9 parts, xanthan gum 4-8 parts, polyoxyethylene castor oil 10-20 parts, isopropyl myristate 8-10 parts, citric acid 6-8 parts and water 16-20 parts by weight.
4. The moxibustion for warming and recuperating kidney yang according to claim 1, wherein the heat generating bag comprises a material bag and a heat generating agent, and the heat generating agent comprises, by weight, 40-80 parts of iron powder, 10-30 parts of water gel, 4-10 parts of an auxiliary dispersant, 10-20 parts of a catalyst, and 5-10 parts of a coupling agent.
5. The moxibustion for warming and recuperating kidney yang according to claim 4, wherein the hydrocolloid comprises the following components in parts by weight: 1-2 parts of high-molecular water-absorbing resin, 2-4 parts of salt and 10-20 parts of water.
6. The moxibustion for warming and recuperating kidney yang according to claim 5, wherein said polymeric water-absorbent resin is polyacrylic acid water-absorbent resin or PVA resin.
7. The moxibustion for warming and recuperating kidney yang according to claim 6, wherein the coupling agent comprises the following components in parts by weight: 1-2 parts of propylene glycol, 10-30 parts of vaseline, 10-20 parts of monoglyceride, 0.5-1 part of polyvinylpyrrolidone and 10-15 parts of lanolin.
8. The moxibustion for warming and recuperating kidney yang according to claim 2, wherein the preparation method of the pharmaceutical composition I comprises:
1) placing rhizoma Curculiginis, herba Epimedii, radix Morindae officinalis and herba Lysimachiae Christinae into superfine jet mill, and pulverizing; then placing the mixture into a traditional Chinese medicine ultrasonic extraction machine, and adding deionized water for extraction; filtering the traditional Chinese medicine liquid in the traditional Chinese medicine ultrasonic extraction machine to obtain nanometer traditional Chinese medicine ultrasonic extraction liquid;
2) placing the ultrasonic extraction liquid of the nano traditional Chinese medicine into a vacuum high-speed dispersion tank, sequentially adding isopropanol, ethanol, hydroxypropyl methylcellulose, lecithin, cholesterol and hyaluronic acid, and uniformly dispersing to obtain a nano traditional Chinese medicine ethosome;
3) placing the nanometer traditional Chinese medicine ethosome into a vacuum high-speed dispersion tank, sequentially adding sodium alginate, glycerol and deionized water, and uniformly dispersing to obtain a medicament composition I.
9. The moxibustion for warming and recuperating kidney yang according to claim 3, wherein the preparation method of the pharmaceutical composition II comprises the following steps:
1) pulverizing radix astragali, radix rehmanniae Preparata and folium Artemisiae Argyi into fine powder to obtain medicinal mixture;
2) oil phase: mixing the medicine mixture, the peppermint essential oil, the oleic acid, the isopropyl myristate and the polyoxyethylene castor oil in an ice-water bath, and uniformly stirring for 20-50 min to form an oil phase;
3) water phase: dissolving xanthan gum, propylene glycol and citric acid in water, and mixing and stirring in an ice-water bath for 10-50 min to form a water phase;
4) microemulsion polymerization: and mixing the oil phase and the water phase, heating to 70-90 ℃ under an oxygen-free condition, carrying out ultrasonic dispersion, mechanically stirring at a speed of 400-800 r/min, carrying out microemulsion polymerization for 3-7 h, and cooling to room temperature to obtain a medicament composition II.
10. The method for preparing moxibustion for warming and recuperating kidney yang according to claim 7, comprising the steps of:
1) preparation of the medicament patch: respectively preparing a medicament composition I and a medicament composition II, then uniformly mixing, and putting into a medicament bag to prepare a medicament patch;
2) preparing a heating bag:
A. weighing the macromolecular water-absorbing resin, the salt and the water according to the proportion, and uniformly mixing to obtain a water gel;
B. weighing propylene glycol, vaseline, monoglyceride, polyvinylpyrrolidone and lanolin according to a ratio, and uniformly mixing to obtain a coupling agent;
C. weighing iron powder, water gel, auxiliary dispersant, catalyst and coupling agent according to the proportion, and uniformly mixing to obtain the heating agent;
D. c, putting the heating agent prepared in the step C into a material belt, and sealing to prepare a heating bag;
3) and (3) mutually bonding the medicament patch prepared in the step 1) and the heating bag prepared in the step 2) to prepare the medicinal moxibustion for warming and invigorating kidney yang.
CN202010818605.7A 2020-08-14 2020-08-14 Medicinal moxibustion for warming and invigorating kidney yang and preparation method thereof Pending CN111920880A (en)

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Application publication date: 20201113