CN111920756A

CN111920756A - Nicotinamide whitening and repairing mask, essence of mask and preparation method of essence

Info

Publication number: CN111920756A
Application number: CN202010954866.1A
Authority: CN
Inventors: 林镇森
Original assignee: Guangzhou Qianzhi Herbal Cosmetics Co ltd
Current assignee: Guangzhou Qianzhi Herbal Cosmetics Co ltd
Priority date: 2020-09-11
Filing date: 2020-09-11
Publication date: 2020-11-13

Abstract

The application relates to the technical field of cosmetics, and particularly discloses a nicotinamide whitening and repairing mask, essence of the nicotinamide whitening and repairing mask and a preparation method of the essence. A nicotinamide whitening and repairing facial mask essence comprises undecylenoyl phenylalanine; a Sargassum blunt extract; a lactobacillus fermentation product; nicotinamide; a thickener; a solvent; the preparation method comprises the following steps: step 1), mixing a solvent and a thickening agent to obtain a first mixture; step 2), adjusting the temperature of the first mixture to 41-45 ℃, and then adding undecylenoyl phenylalanine to the first mixture to obtain a second mixture; and step 3), adding the sargassum obtusifolia extract, the lactobacillus fermentation product and the nicotinamide into the second mixture to obtain the nicotinamide whitening repairing mask essence. The nicotinamide whitening and repairing mask can be used for whitening and repairing skin and has the advantage of improving the multi-effect whitening and repairing of products.

Description

Nicotinamide whitening and repairing mask, essence of mask and preparation method of essence

Technical Field

The application relates to the technical field of cosmetics, in particular to a nicotinamide whitening and repairing mask, essence thereof and a preparation method of the essence.

Background

With the rapid development of the times and the improvement of living standard, more and more women pay attention to skin care and pursue natural, healthy, fair and uniform skin color, and the facial mask is deeply concerned by consumers as a conventional skin care product, in particular to the facial mask with whitening and repairing effects.

In the existing whitening mask, a plurality of substances with whitening components are usually added into essence of the mask, and the mask temporarily isolates outside air and pollution in the air, so that the essence with the whitening effect permeates into the skin, and the skin achieves the whitening effect from inside to outside.

However, with the increase of the pace of life of people, the mask with the single whitening function is difficult to meet the daily needs of people, and after the mask with the single whitening function is used, people also need to repair and care the skin by moisturizing, sterilizing, diminishing inflammation, moistening and the like, so if the same mask has the whitening and repairing functions, the mask can be whitened and repaired simultaneously when being applied, and the skin care efficiency is greatly improved.

In view of the above-mentioned related technologies, the inventor believes that when a substance having a whitening component and a substance having a repairing component are matched with each other, some harmful substances may be released, which may cause negative effects on human skin, damage to skin stratum corneum, lipid, etc., and damage to skin barrier, so that the repairing effect is not lasting, and the skin is prone to dry and tighten after a period of whitening and repairing, which may lead to frequent water replenishment and moisture retention, and poor skin protection effect.

Disclosure of Invention

In order to improve the multi-effect whitening and repairing effect of the product, the application provides a nicotinamide whitening and repairing facial mask, essence of the nicotinamide whitening and repairing facial mask and a preparation method of the essence of the nicotinamide whitening and repairing facial mask.

In a first aspect, the application provides a nicotinamide whitening and repairing mask essence, which adopts the following technical scheme:

the niacinamide whitening and repairing mask essence comprises the following components in percentage by mass:

0.05% -0.15% of undecylenoyl phenylalanine; 0.05-0.15% of sargassum obtusifolia extract; 0.02-0.08% of lactobacillus fermentation product; 0.1% -0.2% of nicotinamide; 0.21 to 0.52 percent of thickening agent; the balance of solvent; the total mass percentage is 100 percent.

By adopting the technical scheme, the undecylenoyl phenylalanine is added, and can be combined with a melanin stimulating hormone receptor MC1-R on a melanocyte, so that the melanocyte can reduce the generation of tyrosinase, inhibit the activity of the melanocyte, reduce the generation of melanin, and further have the effects of whitening and removing freckles.

By adding the sargassum blunt extract, the sargassum blunt extract has good promotion on the activity of fibroblasts and the like, has the functions of activating and moistening the skin, and can improve the natural moisturizing effect in epidermal cells, thereby having the function of deep moisturizing.

By adding the lactobacillus fermentation product, the lactobacillus fermentation product has strong inhibition effect on gram-negative bacteria and gram-positive bacteria, and has better antibacterial and anti-inflammatory effects.

By adding nicotinamide, nicotinamide can act on the skin, inhibit the produced melanin and reduce the transfer of melanin to surface cells so as to accelerate the metabolism of the skin, and also has the function of enhancing the skin barrier function by increasing the content of ceramide in the horny layer, thereby reducing the water loss of the skin and improving and repairing the skin barrier.

Thickener can adopt carbomer, transparent xanthan gum, hydroxyethyl cellulose, xanthan gum etc. in this application, through adding thickener for the thickening effect of product is preferred, and is difficult for producing the amazing to skin, reduces the mobility of product simultaneously, reduces the extravagant condition of facial mask.

By adding the combination of the undecylenoyl phenylalanine, the sargassum blunt extract and the lactobacillus fermentation product, the lactobacillus fermentation product relieves the damage effect of the undecylenoyl phenylalanine and the sargassum blunt extract on the stratum corneum when being combined, thereby reducing the damage to the skin barrier, ensuring that the skin moistening effect of the sargassum blunt extract is more durable, effectively improving the repair effect of the product and ensuring that the product has better multi-effect whitening repair effect.

Preferably, the composition also comprises the following components in percentage by mass:

0.005% -0.15% of caprylic/capric glyceride; 0.02% -0.1% of allantoin; 0.04 to 0.12 percent of dipotassium glycyrrhizinate.

By adopting the technical scheme, the nicotinamide whitening and repairing mask essence has the effects of improving and repairing skin barriers, effectively preventing sensitive inflammation when skin is stimulated, and relieving and anti-allergy effects.

0.001% -0.01% of ceramide NP; phytosphingosine 0.001% -0.01%; 0.001% -0.003% of cholesterol; 0.001 to 0.005 percent of stearic acid; 0.001% -0.005% of oleic acid; 0.002% -0.012% of lactic acid; 0.003-0.007% of octyl glycol.

By adopting the technical scheme, the nicotinamide whitening and repairing mask essence has the effect of enhancing the skin barrier, also has a good moisturizing effect and is less in irritation.

0.2 to 0.6 percent of tranexamic acid; 0.005-0.015% of ditch antler vegetable extract; 0.03% -0.07% of glutathione; 0.02% -0.08% of Enteromorpha compressa extract; 0.005-0.015% of glycyrrhiza glabra extract.

By adopting the technical scheme, the nicotinamide whitening and repairing mask essence has better effects of whitening and tendering skin, relieving and anti-allergy, detoxifying and nourishing skin, resisting inflammation and resisting bacteria.

humectant 4.752% -10.258%; the humectant is one or more of 1.3-butanediol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, propylene glycol, glycerol, glyceryl polyether-26, and amino acid humectant.

By adopting the technical scheme, the moisturizing agent can improve the moisturizing effect of the skin and slow down the water loss speed through adding the moisturizing agent, so that the skin can be kept moist.

Preferably, the humectant comprises the following components in percentage by mass:

0.5 to 1.5 percent of 1.3-butanediol; 1.2-hexanediol 0.2% -0.6%; 50.2 to 0.8 percent of vitamin B; polyethylene glycol polyoxyethylene ether 0.3% -0.7%; 0.002% -0.008% of hydrogenated lecithin; 0.05 to 0.15 percent of propylene glycol; 1.5% -2.5% of glycerin; glycerol polyether-260.5% -1.5%; 1.5 to 2.5 percent of amino acid humectant.

By adopting the technical scheme, the moisture-preserving effect of the product is higher through the matching of the components, so that the humidity of the skin is improved, and the skin can be kept in a healthy state.

octyl hydroximic acid 0.003-0.007%.

By adopting the technical scheme, octyl hydroximic acid is added, and the octyl hydroximic acid has excellent antibacterial and bacteriostatic properties under a neutral pH value, so that the quality of a product is improved.

In a second aspect, the application provides a niacinamide whitening and repairing mask, which adopts the following technical scheme:

a nicotinamide whitening repairing mask comprises mask paper, wherein the mask paper is soaked with the nicotinamide whitening repairing mask essence.

By adopting the technical scheme, the nicotinamide whitening repair mask essence is fully soaked on the mask paper, so that the nicotinamide whitening repair mask has the function of the essence, when the nicotinamide whitening repair mask is pasted on skin, the contact between the facial skin and air is blocked through the mask cloth, the essence is adsorbed on the mask cloth, the essence permeates into the skin, and the skin achieves the effect of deep whitening repair from inside to outside.

In a third aspect, the application provides a preparation method of a nicotinamide whitening and repairing mask essence, which adopts the following technical scheme:

a preparation method of a nicotinamide whitening repairing mask essence comprises the following steps:

step 1), mixing a solvent and a thickening agent, heating to 83-88 ℃, homogenizing for 3-8 minutes, stirring until the thickening agent is completely dissolved, and keeping the temperature at 83-88 ℃ for 28-32 minutes to obtain a first mixture; step 2), adjusting the temperature of the first mixture to 41-45 ℃, then adding the undecylenoyl phenylalanine into the first mixture, and uniformly stirring to obtain a second mixture;

and step 3), adding the sargassum obtusifolia extract, the lactobacillus fermentation product and the nicotinamide into the second mixture, and uniformly stirring to obtain the nicotinamide whitening and repairing mask essence.

By adopting the technical scheme, the thickener is dissolved in the solvent along with the rise of the temperature by mixing the solvent and the thickener and then heating to 83-88 ℃, so that the thickener is uniformly dispersed in the solvent, and the thickener effect of the thickener is further enhanced. The temperature of the first mixture is adjusted to 41-45 ℃, and then the undecylenoyl phenylalanine is added, so that better activity is kept, and better effect is exerted.

Preferably, in the step 1), glycerin polyether-26 and an amino acid humectant are added and stirred uniformly, and then glycerin which is preheated to 88-92 ℃ and cooled for standby is added and stirred uniformly; in the step 2), the extract of the carrageen guer, glutathione, dipotassium glycyrrhizinate and 1.3-butanediol which are mixed with the undecylenoyl phenylalanine in advance are added, and then the mixture is added into the first mixture and stirred uniformly; in the step 3), caprylic acid/capric acid glyceride, Enteromorpha compressa extract, Glycyrrhiza glabra extract, propylene glycol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, tranexamic acid, nicotinamide, ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, hydrogenated lecithin, octyl hydroximic acid and octyl glycol are also added and uniformly stirred.

By adopting the technical scheme, the glycerol which is preheated to 88-92 ℃ and cooled for standby is added, so that the glycerol is dissolved sufficiently at high temperature, and the moisturizing effect of the glycerol and the better dissolution of each component are improved.

By adding the extract of the carrageenin premixed with the undecylenoyl phenylalanine, glutathione, dipotassium glycyrrhizinate and 1.3-butanediol, all the components can be dissolved more fully at low temperature, and simultaneously, higher activity can be kept, and the efficacy of the product is improved.

In summary, the present application has the following beneficial effects:

1. by adding the combination of the undecylenoyl phenylalanine, the sargassum blunt extract and the lactobacillus fermentation product, the lactobacillus fermentation product relieves the damage effect of the undecylenoyl phenylalanine and the sargassum blunt extract on the stratum corneum when being combined, thereby reducing the damage to the skin barrier, further enhancing the skin moistening effect of the sargassum blunt extract, effectively improving the repair effect of the product and ensuring that the product has better multi-effect whitening repair effect;

2. the application preferably adopts the tranexamic acid, the ditch carrageen extract, the glutathione, the Enteromorpha compressa extract and the Glycyrrhiza glabra extract, and the effects of relieving skin, whitening skin, resisting bacteria and inflammation are obtained due to the mutual matching of the components;

3. preferably adopt octyl hydroximic acid in this application, through adding octyl hydroximic acid, further improved antibiotic, antibacterial effect, the stimulation to skin is lower simultaneously, has consequently obtained the lower effect of irritability when improving the anticorrosive effect of product.

Detailed Description

The present application will be described in further detail with reference to examples.

The information on the source of each raw material component in the following examples and comparative examples is shown in Table 1

TABLE 1

Examples 1 to 3

The niacinamide whitening and repairing mask essence comprises the following components:

undecylenoyl phenylalanine, Sargassum blunt extract, caprylic/capric glyceride, nicotinamide, thickener, and solvent; the thickening agent is a compound of carbomer, transparent xanthan gum and hydroxyethyl cellulose; the solvent is deionized water.

The amounts (in Kg) charged in examples 1 to 3 are specified in Table 2

TABLE 2

	Example 1	Example 2	Example 3
				Undecylenoyl phenylalanine	0.05	0.1	0.15
Sargassum fusiforme extract	0.05	0.1	0.15
				Lactobacillus fermentation product	0.02	0.05	0.08
Nicotinamide	0.1	0.15	0.2
				Carbomer	0.1	0.15	0.2
Transparent xanthan gum	0.1	0.2	0.3
				Hydroxyethyl cellulose	0.01	0.015	0.02
Deionized water	99.57	99.235	98.9

Embodiment 1-3 a method for preparing a niacinamide whitening and repairing mask essence comprises the following steps: step 1), adding deionized water, carbomer, transparent xanthan gum and hydroxyethyl cellulose into an emulsifying pot, heating to 85 ℃, homogenizing for 5 minutes, stirring until the materials are completely dissolved, keeping the temperature at 85 ℃ for 30 minutes, and discharging to a container to obtain a first mixture;

step 2), adjusting the temperature of the first mixture to 43 ℃, adding undecylenoyl phenylalanine into the first mixture, and uniformly stirring to obtain a second mixture;

Example 4

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps:

in the step 1), heating to 83 ℃, homogenizing for 3 minutes, and keeping the temperature at 83 ℃ for 28 minutes.

In step 2), the first mixture was adjusted to a temperature of 41 ℃.

Example 5

in the step 1), the mixture is heated to 88 ℃, homogenized for 8 minutes, and kept at 88 ℃ for 32 minutes.

In step 2), the first mixture was adjusted to a temperature of 45 ℃.

Examples 6 to 8

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the nicotinamide whitening and repairing mask essence also comprise allantoin and dipotassium glycyrrhizinate.

In examples 6 to 8, the amounts (in Kg) of allantoin and dipotassium glycyrrhizinate added are shown in Table 3, Table 3

	Example 6	Example 7	Example 8
				Caprylic/capric glycerides	0.005	0.01	0.015
Allantoin	0.02	0.06	0.1
				Glycyrrhizic acid dipotassium salt	0.04	0.08	0.12

Adding allantoin, deionized water, carbomer, transparent xanthan gum and hydroxyethyl cellulose into the emulsifying pot in the step 1), and stirring uniformly.

The dipotassium glycyrrhizinate is first premixed with undecylenoyl phenylalanine in step 2).

Adding caprylic/capric acid glyceride, the sargassum obtusifolia extract, the lactobacillus fermentation product and the nicotinamide into the second mixture in the step 3), and uniformly stirring.

Examples 9 to 11

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the niacinamide whitening and repairing mask essence also comprise ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid and octyl glycol.

The contents (in Kg) of ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, and caprylyl glycol in examples 9 to 11 are shown in Table 4

TABLE 4

	Example 9	Example 10	Example 11
				Ceramide NP	0.001	0.005	0.01
Phytosphingosine	0.001	0.005	0.01
				Cholesterol	0.001	0.002	0.003
Oleic acid	0.001	0.003	0.005
				Oleic acid	0.001	0.003	0.005
Octylethylene glycol	0.002	0.007	0.012

Ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, octyl glycol are added to the second mixture together with the Sargassum blunt extract, the lactobacillus fermentation product, and nicotinamide in step 3), and stirred uniformly.

Examples 12 to 14

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the nicotinamide whitening and repairing mask essence also comprise tranexamic acid, a ditch carrageen extract, glutathione, an enteromorpha plancha extract and a glycyrrhiza glabra extract.

The amounts (in Kg) of tranexamic acid, extract of carrageenin, glutathione, extract of Enteromorpha compressa and extract of Glycyrrhiza glabra in examples 12 to 14 are shown in Table 5

TABLE 5

	Example 12	Example 13	Example 14
				Tranexamic acid	0.2	0.4	0.6
Extract of Pelvetia siliquosa	0.02	0.05	0.08
				Glutathione	0.03	0.05	0.07
Enteromorpha compressa extract	0.02	0.05	0.08
				Glycyrrhiza glabra extract	0.005	0.01	0.015

Adding tranexamic acid, the carrageen guttatus extract, glutathione, the enteromorpha compressa extract and the glycyrrhiza glabra extract in the step 3) into the second mixture together with the gulfweed extract, the lactobacillus fermentation product and the nicotinamide, and uniformly stirring.

Examples 15 to 17

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the niacinamide whitening and repairing mask essence also comprise a humectant. The humectant is a compound of 1.3-butanediol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, propylene glycol, glycerol, glyceryl polyether-26, and amino acid humectant.

In examples 15 to 17, the amounts (in Kg) of 1.3-butanediol, 1.2-hexanediol, vitamin B5, polyoxyethylene polyethylene glycol ether, hydrogenated lecithin, propylene glycol, glycerin, glyceryl polyether-26, and an amino acid humectant are shown in Table 6

TABLE 6

	Example 15	Example 16	Example 17
				1, 3-butanediol	0.5	1	1.5
1, 2-hexanediol	0.2	0.4	0.6
				Vitamin B5	0.2	0.5	0.8
Polyethylene glycol polyoxyethylene ether	0.3	0.5	0.7
				Hydrogenated lecithin	0.002	0.005	0.008
Propylene glycol	0.05	0.1	0.15
				Glycerol	1.5	2	2.5
Glycerol polyether-26	0.5	1	1.5
				Amino acid humectant	1.5	2	2.5

And (2) adding the glyceryl polyether-26 and the amino acid humectant into an emulsifying pot together with deionized water, carbomer, transparent xanthan gum and hydroxyethyl cellulose in the step 1), heating to 85 ℃ while stirring, homogenizing for 5 minutes, adding the glycerol which is heated to 90 ℃ and cooled for later use, and uniformly stirring.

1.3-butanediol is premixed in step 2) with undecylenoylphenylalanine.

Adding 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, and propylene glycol in step 3), adding the mixture, the fermentation product of Lactobacillus and nicotinamide, and stirring.

Examples 18 to 20

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the component of the nicotinamide whitening repairing mask essence also comprises octyl hydroximic acid.

The amounts (in Kg) of octyl hydroxamic acid dosed in examples 18-20 are detailed in Table 7

TABLE 7

	Example 18	Example 19	Example 20
				Octyl hydroximic acid	0.003	0.005	0.007

Octyl hydroximic acid is added to the second mixture in step 3) along with the gulfweed extract, the lactobacillus fermentation product, and niacinamide and stirred uniformly.

Examples 21 to 23

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the nicotinamide whitening repairing mask essence also comprise: isothiazolinone/iodopropynyl butylcarbamate, antioxidant, pH regulator, perfume, solubilizer, and chelating agent.

The antioxidant is p-hydroxyacetophenone; the pH regulator is sodium hydroxide; the spice is the compound of orange flower essential oil and thyme essential oil; the solubilizer is hydrogenated castor oil; the chelating agent is disodium ethylene diamine tetraacetate. In examples 21-23, the amounts (in Kg) of isothiazolone/iodopropynyl butylcarbamate, antioxidant, pH adjuster, fragrance, solubilizer, and chelating agent added are shown in Table 8, Table 8

Adding disodium ethylene diamine tetraacetate, deionized water, carbomer, transparent xanthan gum and hydroxyethyl cellulose into an emulsifying pot in the step 1), heating to 85 ℃ while stirring, homogenizing for 5 minutes, adding a premixed solution of glycerol and p-hydroxyacetophenone which is mixed, heated to 90 ℃ and cooled for later use, and uniformly stirring. Taking 1% deionized water and sodium hydroxide for pre-dissolving, mixing the pre-dissolved sodium hydroxide with the first mixture when the temperature of the pre-dissolved sodium hydroxide is reduced to 45 ℃ in the step 1), and uniformly stirring. The orange flower essential oil, the thyme essential oil and the hydrogenated castor oil are mixed and stirred uniformly, and then are added into the second mixture together with the gulfweed extract, the lactobacillus fermentation product and the nicotinamide in the step 3), and the mixture is stirred uniformly.

Examples 24 to 26

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the components of the nicotinamide whitening repairing mask essence also comprise: allantoin, dipotassium glycyrrhizinate, ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, caprylyl glycol, tranexamic acid, Pelvetia canaliculata extract, glutathione, Enteromorpha compressa extract, Glycyrrhiza glabra extract, a humectant, a lactobacillus fermentation product, octyl hydroximic acid, methylisothiazolinone/iodopropynyl butylcarbamate, an antioxidant, a pH regulator, a fragrance, a solubilizer, and a chelating agent. The humectant is a compound of 1.3-butanediol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, propylene glycol, glycerol, glyceryl polyether-26 and amino acid humectant; the antioxidant is p-hydroxyacetophenone; the pH regulator is sodium hydroxide; the spice is the compound of orange flower essential oil and thyme essential oil; the chelating agent is disodium ethylene diamine tetraacetate. In examples 24 to 26, the amounts (in Kg) of the respective components charged are shown in Table 9

TABLE 9

Allantoin, glyceryl polyether-26, an amino acid humectant and ethylene diamine tetraacetic acid are added into an emulsifying pot together with deionized water, carbomer, transparent xanthan gum and hydroxyethyl cellulose in the step 1), the mixture is heated to 85 ℃ while stirring, homogenized for 5 minutes, then mixed and heated to 90 ℃, cooled for later use, the glycerol and p-hydroxyacetophenone premix is added, and the mixture is stirred uniformly.

Taking 1% deionized water and sodium hydroxide for pre-dissolving, mixing the pre-dissolved sodium hydroxide with the first mixture when the temperature of the pre-dissolved sodium hydroxide is reduced to 45 ℃ in the step 1), and uniformly stirring.

1.3-butanediol, Pelvetia siliquosa extract, glutathione, and dipotassium glycyrrhizinate in step 2) are pre-mixed with undecylenoyl phenylalanine, and then added to the first mixture and stirred uniformly. Ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, octyl glycol, caprylic/capric glyceride, tranexamic acid, Enteromorpha compressa extract, Glycyrrhiza glabra extract, 1, 2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, propylene glycol and octyl hydroximic acid are uniformly mixed with the Sargassum blunt extract, the lactobacillus fermentation product and the nicotinamide in the step 3), and then a mixed solution of orange flower essential oil, thyme essential oil and hydrogenated castor oil is added and stirred uniformly.

Examples 27 to 52

A nicotinamide whitening repairing mask, which comprises mask paper, wherein the mask paper is soaked with nicotinamide whitening repairing mask essence, in examples 27-52, the nicotinamide whitening repairing mask essence respectively adopts the amide whitening repairing mask essence in examples 1-26.

Comparative example 1

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in step 2) an equivalent amount of water was used instead of undecylenoyl phenylalanine. In the step 3), the sargassum obtusifolia extract, the lactobacillus fermentation product and the nicotinamide are replaced by the same amount of water.

Comparative example 2

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in the step 3), the sargassum obtusifolia extract, the lactobacillus fermentation product and the nicotinamide are replaced by the same amount of water.

Comparative example 3

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in step 2) an equivalent amount of water was used instead of undecylenoyl phenylalanine. In the step 3), the lactobacillus fermentation product and the nicotinamide are replaced by the same amount of water.

Comparative example 4

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in step 2) an equivalent amount of water was used instead of undecylenoyl phenylalanine. In the step 3), the sargassum obtusifolia extract and the nicotinamide are replaced by the same amount of water.

Comparative example 5

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in the step 3), the lactobacillus fermentation product and the nicotinamide are replaced by the same amount of water.

Comparative example 6

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in the step 3), the sargassum obtusifolia extract and the nicotinamide are replaced by the same amount of water.

Comparative example 7

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in step 2) an equivalent amount of water was used instead of undecylenoyl phenylalanine. In the step 3), the same amount of water is used for replacing nicotinamide.

Comparative example 8

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in the step 3), the same amount of water is used for replacing nicotinamide.

Comparative example 9

Compared with the example 2, the nicotinamide whitening repairing mask essence is only different from the example 2 in that: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps: in the step 3), the nicotinamide and the lactobacillus fermentation product are replaced by the same amount of water and the squalane.

Experiment 1

Tyrosinase activity inhibition assay: the test method comprises the following steps: according to the group standard T/SHRH015-2018 cosmetic-tyrosinase activity inhibition experiment method, the tyrosinase activity inhibition rate of the nicotinamide whitening repairing mask essence prepared in each embodiment and comparative example is detected.

Experiment 2

The moisturizing effect of the niacinamide whitening and repairing mask essence prepared in each embodiment and comparative example is detected according to QB/T4256-2011 'evaluation guideline for moisturizing efficacy of cosmetics' in light industry standard. The test method comprises the following steps: 99 healthy volunteers aged 18-25 years were randomized into 33 groups of 3 adult volunteers each. Under a constant temperature environment (22 +/-1 ℃), the relative humidity is 50 +/-5%, and after 1 hour of rest, the hydration degree of the tested part of each group of testees has no obvious difference before use. According to (2.0 +/-0.1) mg/cm²The nicotinamide whitening repair mask essence prepared in each example and comparative example is weighed on the inner sides of the forearms of the two hands of a subject, measurement area marks are made, the area of a test area is (3cm x 3cm), the interval between every two test areas is 1.5cm, the test is carried out simultaneously, the hydration state of the skin is tested 1 hour and 4 hours after the nicotinamide whitening repair mask essence prepared in each example and comparative example is coated, and the evaluation result is represented by the average value of the hydration degree.

Experiment 3

An equivalent amount of 0.25% Sodium Dodecyl Sulfate (SDS) (surfactant) was added to the essence of the niacinamide whitening and repairing mask prepared in each of examples and comparative examples, and after 24 hours, the degree of injury of the skin module was observed, the amount of IL-lalpha (cytokine) was examined under a wavelength of 450nm using an ELISA microplate reader, and the absorbance was calculated by dividing the absorbance of each of examples and comparative examples by the absorbance of comparative example 1 and multiplying by 100% according to the absorbance measured in comparative example 1 as a reference value, to evaluate the result of inflammatory reaction.

Experiment 4

Through the skin water loss TWEL value experiment: the test method comprises the following steps: according to T/ZHCA 003-. The percutaneous water loss better represents the integrity of the skin barrier function, the higher the TWEL value is, the more the transepidermal water loss is, on the contrary, the lower the TWEL value is, the less the transepidermal water loss is, the skin barrier is improved and repaired.

Experiment 5

Test subjects for fair and humidity: 102 adult volunteers 18-25 years old are selected, randomly and evenly divided into 34 groups of 3, and before use, the facial humidity and the white degree of each group of the test subjects have no obvious difference. After cleaning face, the product is applied on nose, lip, eye, etc., air is squeezed out, and facial mask paper is removed after 15 minutes without cleaning, and is used for 3 times per week for 2 months. The test method comprises the following steps: after washing the face, the intelligent whitening detector (Shenzhen Meili Zhi science and technology Co., Ltd.) was used to read the whiteness and humidity of the skin without applying any cosmetic product. The degree of whiteness and humidity (average) of the face before and after application of the niacinamide whitening and repairing mask to each group of subjects was recorded.

The assay data for experiments 1-4 are shown in Table 9. The data for the assay of experiment 5 are shown in Table 10.

TABLE 9

According to the comparison of the data of comparative example 2 and comparative example 1 in table 9, the inhibition rate of tyrosinase activity is greatly improved by adding undecylenoyl phenylalanine, which proves that undecylenoyl phenylalanine can reduce the generation of melanin, has the effects of whitening skin and removing freckles, and has no obvious change of the water loss value of epidermis and no obvious effect on skin barrier.

According to the comparison of the data of comparative example 3 and comparative example 1 in table 9, the addition of the sargassum obtusifolia extract results in a large increase in the degree of hydration, which proves that the skin-moisturizing and moisturizing effects are achieved, the TWEL value is not significantly changed by the loss of epidermal water, and the skin-repairing and protecting effects are not significant.

According to the comparison of the data of comparative example 4 and comparative example 1 in Table 9, the absorbance is significantly decreased by adding the lactobacillus fermentation product, which indicates that IL-lalpha causing cell inflammation is decreased, and the lactobacillus fermentation product can reduce the cell damage caused by detergent contact, facilitate the repair of damaged cells, and reduce inflammation caused by cell division.

According to the comparison of the data of comparative example 6 and comparative example 2 in table 9, the tyrosinase activity inhibition rate was slightly increased and slightly changed when the undecylenoyl phenylalanine was used in combination with the lactobacillus fermentation product, which proves that the lactobacillus fermentation product had no significant negative effect on the undecylenoyl phenylalanine, and the epidermis moisture loss value had no significant change, which proves that the combination of the undecylenoyl phenylalanine and the lactobacillus fermentation product had no significant negative effect on the skin barrier.

According to the comparison of the data of comparative examples 7 and 3 in table 9, the hydration degree of the sargassum blunt extract and the lactobacillus fermentation product is slightly increased and slightly changed, which indicates that the lactobacillus fermentation product has no obvious negative effect on the sargassum blunt extract, the change of the epidermal water loss value is less obvious, and the influence of the combination of the sargassum blunt extract and the lactobacillus fermentation product on the skin barrier is less.

According to the comparison of the data of comparative example 5, comparative example 2 and comparative example 3 in table 9, it can be seen that when the undecylenoyl phenylalanine is used in combination with the Sargassum blunt extract, the hydration degree of the Sargassum blunt extract is reduced to a certain extent, and the reduction range is large with the time, and the moisture loss value of the epidermis is obviously increased, which proves that the skin barrier function is damaged by the combination of the undecylenoyl phenylalanine and the Sargassum blunt extract, so that the efficacy of the moisturizing effect is not durable, and the product repairing effect is poor.

According to the comparison of the data of comparative example 8 and comparative example 5 in table 9, the degree of hydration is greatly improved to a certain extent by adding the lactobacillus fermentation product, and the reduction is gentle along with the time, and the water loss value through epidermis is greatly reduced to a certain extent, so that the lactobacillus fermentation product relieves the damage of the interaction of the undecylenoyl phenylalanine and the sargassum obtusifolium extract to the skin barrier, the light absorption rate is obviously reduced, the IL-lalpha causing cell inflammation is reduced, and the lactobacillus fermentation product has a good anti-inflammatory effect, so that the persistence of the moisturizing effect is further improved, and the multi-effect whitening and repairing effect of the product is further enhanced.

According to the comparison of the data of comparative example 9 and comparative example 5 in table 9, the tyrosinase activity inhibition rate, the hydration degree and the value of the water loss through epidermis are not obviously changed by adding the conventional skin barrier repairing agent, and the addition of the conventional skin barrier repairing agent proves that the effect of relieving the damage effect of the matching of the undecylenoyl phenylalanine and the sargassum obtusifolium extract on the skin barrier is not obvious, the hydration degree is greatly reduced along with the prolonging of time, the light absorption rate is not obviously changed, and the inflammation has a certain effect on the skin repairing barrier, so that the moisturizing effect is not durable, further, the effect of repairing the skin barrier is not good, and the multi-effect whitening repairing effect is not ideal.

As can be seen from comparison of the data of comparative example 8 and example 2 in table 9, the tyrosinase activity inhibition ratio was improved to some extent by adding niacinamide, demonstrating that niacinamide has a superior whitening effect.

According to the comparison of the data of examples 6 to 8 and example 2 in table 9, the addition of caprylic/capric glyceride, allantoin and dipotassium glycyrrhizinate results in a certain improvement in the hydration degree and the TWEL value through epidermal water loss, which proves that the skin care cream has the effects of further repairing the skin barrier, improving the skin moisturizing effect, reducing the light absorption rate, and showing that the skin care cream has a certain anti-inflammatory effect and is further beneficial to improving and repairing the skin barrier.

According to the comparison of the data of examples 9-11 and example 2 in Table 9, the hydration degree and the trans-epidermal water loss value are improved to some extent by adding ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid and lactic acid, which proves that the moisturizing and repairing effects are achieved.

According to comparison of data of examples 12-14 and example 2 in table 9, the tyrosinase activity inhibition rate is increased to a certain extent by adding tranexamic acid, the carrageen guttatus extract, glutathione, the enteromorpha oblata extract and the glycyrrhiza glabra extract, which indicates that the whitening effect is achieved, and the absorbance is reduced to a certain extent, thus proving that the skin-repairing and skin-protecting effects are further improved by having antibacterial and anti-inflammatory effects.

As can be seen from comparison of the data in Table 9 for examples 15-17 with example 2, the degree of hydration was improved to some extent by the addition of the humectant, demonstrating a moisturizing effect.

According to the comparison of the data of examples 18-20 and example 2 in Table 9, the addition of octyl hydroximic acid, which is proved to have a certain bacteriostatic action through a certain increase of the epidermal water loss value, is beneficial to repair the skin barrier.

Watch 10

As can be seen from the comparison of the data in comparative example 2 and comparative example 1 in Table 10, the addition of undecylenoyl phenylalanine greatly improved the whiteness, indicating a better whitening effect.

As can be seen from comparison of the data of comparative example 3 and comparative example 1 in Table 10, the addition of the extract of Bluella vulgaris results in a large increase in humidity, which proves that the moisturizing effect is high.

As can be seen from comparison of the data in table 10 in comparative example 4 with that in comparative example 1, the whiteness and humidity were not significantly changed by adding the lactic acid bacteria fermentation product, and it was confirmed that the lactic acid bacteria fermentation product had little effect of whitening and moisturizing the skin.

As can be seen from comparison of the data in Table 10 in comparative example 6 with comparative example 2, when undecylenoyl phenylalanine was complexed with the lactic acid bacteria fermentation product, there was no significant change in whiteness and humidity, demonstrating that the lactic acid bacteria fermentation product had no significant effect on undecylenoyl phenylalanine.

As can be seen from comparison of the data in table 10 in comparative example 7 and comparative example 3, when the extract of sargassum blunt was used in combination with the lactic acid bacteria fermentation product, the changes in whiteness and humidity were not significant, and it was confirmed that the effect of the lactic acid bacteria fermentation product on the extract of sargassum blunt was not significant.

As can be seen from comparison of the data in table 10 in comparative example 5 with comparative examples 2 and 3, when undecylenoyl phenylalanine is used in combination with the Sargassum blunt Rotundiflora extract, both the whiteness and the humidity are significantly reduced, which indicates that the combination of undecylenoyl phenylalanine and the Sargassum blunt extract damages the horny layer of the skin, reduces the barrier function of the skin, reduces the effect of the skin on nutrients, and further causes the whitening and moisturizing effects to be poor.

According to the comparison of the data of comparative example 8 and comparative example 5 in table 10, the lactobacillus fermentation product relieves the damage of the undecenoylphenylalanine to the horny layer when being combined with the sargassum obtusifolia extract, and promotes and repairs the skin barrier by adding the lactobacillus fermentation product, thereby improving the absorption of nutrient substances and moisture by the skin and improving the whitening, moisturizing and repairing effects.

From the comparison of the data of comparative example 9 and comparative example 5 in Table 10, it was confirmed that the addition of the conventional skin barrier repair agent had no significant effect on the repair of the skin barrier, since there was no significant change in the whiteness and humidity.

According to the comparison between the data of comparative example 8 and the data of example 2 in table 10, the whitening effect is greatly improved by adding niacinamide, which indicates that niacinamide has better whitening effect.

According to the comparison of the data of examples 6-8 and example 2 in table 10, the humidity is improved better to some extent by adding caprylic/capric glyceride, allantoin and dipotassium glycyrrhizinate, which indicates that the skin barrier is further repaired, so that the humidity of the skin is further improved, and the skin is kept in a healthier state.

According to the comparison of the data of examples 9-11 and example 2 in Table 10, the moisture content is increased by adding ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, and lactic acid, which indicates that the moisturizing and repairing effects are achieved.

According to comparison of the data of examples 12 to 14 and example 2 in table 10, the addition of hyaluronic acid, carrageen guttifera extract, glutathione, Enteromorpha compressa extract, and Glycyrrhiza glabra extract improved the whiteness to some extent, demonstrating a better whitening effect.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. The nicotinamide whitening repair mask essence is characterized in that: the composite material comprises the following components in percentage by mass:

0.05% -0.15% of undecylenoyl phenylalanine;

0.05-0.15% of sargassum obtusifolia extract;

0.02-0.08% of lactobacillus fermentation product;

0.1% -0.2% of nicotinamide;

0.21 to 0.52 percent of thickening agent;

the balance of solvent;

the total mass percentage is 100 percent.

2. The nicotinamide whitening repair mask essence of claim 1, which is characterized in that: the paint also comprises the following components in percentage by mass:

0.005% -0.15% of caprylic/capric glyceride;

0.02% -0.1% of allantoin;

0.04 to 0.12 percent of dipotassium glycyrrhizinate.

3. The nicotinamide whitening repair mask essence of claim 1, which is characterized in that: the paint also comprises the following components in percentage by mass:

0.001% -0.01% of ceramide NP;

phytosphingosine 0.001% -0.01%;

0.001% -0.003% of cholesterol;

0.001 to 0.005 percent of stearic acid;

0.001% -0.005% of oleic acid;

0.002% -0.012% of lactic acid;

0.003-0.007% of octyl glycol.

4. The nicotinamide whitening repair mask essence of claim 1, which is characterized in that: the paint also comprises the following components in percentage by mass:

0.2 to 0.6 percent of tranexamic acid;

0.005-0.015% of ditch antler vegetable extract;

0.03% -0.07% of glutathione;

0.02% -0.08% of Enteromorpha compressa extract;

0.005-0.015% of glycyrrhiza glabra extract.

5. The nicotinamide whitening repair mask essence of claim 1, which is characterized in that: the paint also comprises the following components in percentage by mass:

humectant 4.752% -10.258%;

the humectant is one or more of 1.3-butanediol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, hydrogenated lecithin, propylene glycol, glycerol, glyceryl polyether-26, and amino acid humectant.

6. The nicotinamide whitening repair mask essence of claim 5, which is characterized in that: the humectant comprises the following components in percentage by mass:

0.5 to 1.5 percent of 1.3-butanediol;

1.2-hexanediol 0.2% -0.6%;

50.2 to 0.8 percent of vitamin B;

polyethylene glycol polyoxyethylene ether 0.3% -0.7%;

0.002% -0.008% of hydrogenated lecithin;

0.05 to 0.15 percent of propylene glycol;

1.5% -2.5% of glycerin;

glycerol polyether-260.5% -1.5%;

1.5 to 2.5 percent of amino acid humectant.

7. The nicotinamide whitening repair mask essence of claim 1, which is characterized in that: the paint also comprises the following components in percentage by mass:

octyl hydroximic acid 0.003-0.007%.

8. A nicotinamide whitening repairing mask is characterized in that: the niacinamide whitening and repairing facial mask essence comprises facial mask paper, wherein the facial mask paper is soaked with the niacinamide whitening and repairing facial mask essence of any one of claims 1-7.

9. The preparation method of the nicotinamide whitening repairing mask essence of claim 1 is characterized by comprising the following steps: the preparation method of the nicotinamide whitening repairing mask essence comprises the following steps:

step 1), mixing a solvent and a thickening agent, heating to 83-88 ℃, homogenizing for 3-8 minutes, stirring until the thickening agent is completely dissolved, and keeping the temperature at 83-88 ℃ for 28-32 minutes to obtain a first mixture;

step 2), adjusting the temperature of the first mixture to 41-45 ℃, then adding the undecylenoyl phenylalanine into the first mixture, and uniformly stirring to obtain a second mixture;

10. The preparation method of the nicotinamide whitening repairing mask essence of claim 9 is characterized by comprising the following steps: in the step 1), glycerin polyether-26 and an amino acid humectant are added and stirred uniformly, and then glycerin which is preheated to 88-92 ℃ and cooled for standby use is added and stirred uniformly;

in the step 2), the extract of the carrageen guer, glutathione, dipotassium glycyrrhizinate and 1.3-butanediol which are mixed with the undecylenoyl phenylalanine in advance are added, and then the mixture is added into the first mixture and stirred uniformly;

in the step 3), caprylic acid/capric acid glyceride, Enteromorpha compressa extract, Glycyrrhiza glabra extract, propylene glycol, 1.2-hexanediol, vitamin B5, polyethylene glycol polyoxyethylene ether, tranexamic acid, nicotinamide, ceramide NP, phytosphingosine, cholesterol, stearic acid, oleic acid, lactic acid, hydrogenated lecithin, octyl hydroximic acid and octyl glycol are also added and uniformly stirred.