CN111904911B - Panax notoginseng-containing plant antioxidant composition and application thereof - Google Patents
Panax notoginseng-containing plant antioxidant composition and application thereof Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention provides a plant antioxidant composition containing pseudo-ginseng, which is prepared from the following raw materials in parts by weight: 0.1-50 parts of fresh pseudo-ginseng freeze-dried tablets, 0.1-50 parts of giant knotweed rhizome, 0.1-50 parts of white plum blossom and 1-60 parts of aloe leaves. The plant antioxidant composition containing the pseudo-ginseng has a removing effect on various free radicals, has the effects of resisting and repairing oxidative damage, maintains redox balance, is natural and harmless, and can be prepared into daily chemical products such as face cleaning foam, face cleaning gel, face cleaning milk, essence liquid, essence spray, essence water, mask cream, mask liquid, skin care milk and the like.
Description
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to a plant antioxidant composition containing pseudo-ginseng and application thereof.
Background
In organisms, redox reactions are the most basic and important biological reactions. The redox reaction can trigger cascade electron transfer and oxidation and reduction changes of series key factors, and key active substances and active processes are activated or inactivated. In 1894, henry John HorstmanFenton first discovered Reactive Oxygen Species (ROS) free radicals in vivo, and under physiological conditions, the production and elimination of highly reactive molecules of the ROS free radical species were maintained at steady state levels and equilibrium states.
However, with the aging, the ability of the human body to scavenge free radicals gradually decreases, and the increased environmental pollution also causes the generation of more free radicals in the body, and when the generation of free radicals exceeds the ability of the body to scavenge free radicals, the redox balance is disturbed, so that oxidative stress occurs, and various macromolecules (DNA, protein and lipid) are damaged, and then various diseases occur and develop. Human skin, especially important target tissue damaged by various physicochemical factors, such as ultraviolet rays and environmental pollutants, may cause damage to the structure and function of the skin. There is increasing evidence that an imbalance in skin oxidation and antioxidant homeostasis is directly associated with skin aging, dryness, pigmentation, and the like. Meanwhile, severe skin lesions such as allergic dermatitis and stain formation are also closely related to oxidative damage.
In recent years, the concept of oxidative damage and protection of skin has been keen, and it is important to find antioxidants capable of scavenging free radicals and to study the antioxidant mechanisms thereof. The antioxidant has remarkable preventing and improving effects on skin aging, pathological changes and the like caused by oxidative stress injury of the skin. Some clinical trials have shown that proper antioxidant supplementation can improve the body's free radical scavenging ability. For example, many superoxide dismutase (SOD), vitamin C, vitamin E, etc. are currently used. However, many antioxidants have the defects of poor solubility, poor stability, low bioavailability, skin irritation and the like, so that the antioxidant effect of the antioxidants cannot be well exerted.
Chinese herbal medicines in China are potential natural antioxidant resources, at present, a plurality of Chinese herbal medicines are found to have remarkable antioxidant effects, and meanwhile, the Chinese herbal medicines are natural, mild and non-irritant and are dissatisfactory with the demands of consumers on commercial daily chemical products.
At present, with the increasing demand of people for plant antioxidants, although there are reports of multiple plant antioxidants, most of the related researches only focus on individual antioxidants, the antioxidant system is a complex system, and relates to multi-pathway action, the antioxidant capacity of a single plant antioxidant is limited, and meanwhile, the known antioxidants, such as vitamin C, vitamin E, astaxanthin, beta carotene, lipoic acid and the like, show the problems of unstable components, poor absorption and utilization, certain stimulation to skin and the like.
Therefore, the technical problem to be solved by the present invention is to develop a natural and harmless plant composition having scavenging effect on various free radicals, simultaneously having the effect of resisting and repairing oxidative damage, maintaining redox balance, and its application in the preparation of daily chemical products.
Disclosure of Invention
In view of this, the invention provides a plant antioxidant composition containing notoginseng and an application thereof in preparing daily chemical products.
In order to achieve the purpose, the invention adopts the following technical scheme:
a plant antioxidant composition containing pseudo-ginseng is prepared from the following raw materials in parts by weight: 0.1-50 parts of fresh pseudo-ginseng freeze-dried tablets, 0.1-50 parts of giant knotweed rhizome, 0.1-50 parts of white plum blossom and 1-60 parts of aloe leaves.
The invention mechanism of the invention is as follows: the pseudo-ginseng can improve the level of antioxidase, so that the whole body has stronger functions of resisting free radicals and resisting oxidation; giant knotweed has wide pharmacological activity, such as anti-inflammatory, antiviral, antibacterial, myocardial protection, antioxidation, antitumor and the like, can strengthen the natural defense mechanism of skin and help resist the damage of the environment; the prunus mume has effects of scavenging oxygen free radicals, preventing melanin deposition, resisting platelet aggregation, resisting depression, etc., and can brighten skin color and make skin become youthful; aloe contains free radical scavenging component, has effects of caring skin, resisting corrosion, delaying aging, preventing sunburn, effectively inhibiting ultraviolet in sunlight, and preventing pigmentation. In the invention, the injury of skin caused by free radical oxidation and the blood stasis caused by liver loss are considered in a related way, the formula is performed according to the theory of traditional Chinese medicine, pseudo-ginseng is taken as the monarch drug, the strong blood circulation and blood stasis removing effects are obtained, meanwhile, as pseudo-ginseng is the monarch drug, fresh freeze-dried pseudo-ginseng slices which are most complete in preservation and least in influence on each component of pseudo-ginseng are selected to be added into the drug, the effect can be exerted to the maximum extent, the property, the taste, the sweetness and the bitterness of pseudo-ginseng are further taken as the property, the taste, the flavor, the synergistic effect and the property of the giant knotweed which are both taken in the liver channel and the blood stasis dispersing effect, the sweet and the warm property of the pseudo-ginseng are harmonized with the bitter and cold of the giant knotweed, the influence on the body caused by the drug bias is reduced, the heat clearing and the detoxification of the pseudo-ginseng can also reduce the blood circulation, the blood circulation in the vessels, and the nourishment of the blood vessels are assisted by the plum blossom which has the root and the liver channel. Finally, aloe for clearing liver-fire, purging fire and curing malnutrition is added to nourish yin in blood. The four ingredients enter liver meridian, warm and cold, and sweet and bitter, and coordinate liver smoothing and flow of qi together, besides, the four ingredients are heavy respectively, and have the effect of dispersing blood stasis and clearing heat simultaneously, and are compatible with each other to achieve the effects of dispersing blood stasis, promoting blood circulation, clearing heat and removing toxicity, and nourishing blood and pulse.
The beneficial effects of the invention are: the plant antioxidant composition containing Notoginseng radix has effects of scavenging DPPH free radical, ABTS free radical, superoxide anion free radical, hydroxyl free radical, etc., and can remarkably resist and repair injury caused by oxidation to human epidermal fibroblast, maintain redox balance, resist cell aging, and is natural, harmless, and non-cytotoxic.
Preferably, the plant antioxidant composition containing the pseudo-ginseng is prepared from the following raw materials in parts by weight: 40 parts of fresh panax notoginseng freeze-dried tablets, 40 parts of giant knotweed, 15 parts of white plum blossom and 5 parts of aloe leaves.
The invention also provides a preparation method of the plant antioxidant composition containing pseudo-ginseng, which comprises the following steps:
(1) Weighing the raw materials according to the plant antioxidant composition containing pseudo-ginseng as described in claim 1 or 2;
(2) Adding solvent into fresh radix Notoginseng lyophilized tablet, heating and reflux extracting, filtering the extractive solution, and concentrating to obtain concentrated solution;
(3) Respectively pulverizing rhizoma Polygoni Cuspidati and flos Pruni mume, adding solvent, heating under reflux, filtering the extractive solution, and concentrating to obtain concentrated solution;
(4) Cutting folium Aloe into small pieces, lyophilizing, and pulverizing to obtain lyophilized powder;
(5) And (4) carrying out ultrasonic treatment on the concentrated solution obtained in the step (2) and the concentrated solution obtained in the step (3) and the freeze-dried powder obtained in the step (4), passing through a macroporous resin column, eluting, combining the eluates, and drying to obtain the plant antioxidant composition containing pseudo-ginseng.
Further, in the step (2), adding ethanol with the volume concentration of 5-90% into the fresh panax notoginseng freeze-dried tablets, heating to 40-90 ℃, extracting under reflux for 1-3 times, wherein a solvent with the mass of 3-20 times that of the raw materials is adopted each time, the extraction time is 30-180 minutes, and filtering and concentrating the extracting solution to obtain a concentrated solution containing 0.2-1.2 g of crude drugs per gram for later use.
Further, in the step (3), the giant knotweed rhizome and the white plum blossom are respectively crushed to 3 to 30 meshes, ethanol with the volume concentration of 5 to 90 percent is added, the temperature is heated to 40 to 90 ℃, reflux extraction is carried out for 1 to 3 times, a solvent with the mass of 3 to 20 times of the raw material is adopted each time, the extraction time is 30 to 180 minutes, and the extracting solution is filtered and concentrated to obtain concentrated solution containing 0.2 to 1.2 grams of the crude drug per gram for standby.
The adoption of the further beneficial effects is as follows: the fresh freeze-dried pseudo-ginseng slices can be used for treating pseudo-ginseng most timely and completely and storing various effective components of pseudo-ginseng with the smallest influence, and the fresh freeze-dried pseudo-ginseng slices can be directly used for medicine extraction, so that the loss of rare medicinal materials caused by crushing can be reduced, and the efficacy is exerted to the maximum. The freeze-dried fresh pseudo-ginseng slices, the giant knotweed rhizome and the white plum blossom are extracted by ethanol, so that the adverse effects of impurities with too large or too small molecular weight on color, efficacy and solubility of the preparation are reduced, the efficacy components are selected more pertinently, and the quality is controlled. Meanwhile, the concentrated solution is concentrated to a certain concentration, so that the energy consumption in the drying process is reduced, and the loss of components due to incomplete redissolution is avoided when the components pass through the column.
Further, in the step (4), the aloe leaves are cut into 1cm 3 Freeze drying the small blocks at-20 deg.C to-90 deg.C under 0.02-0.2Mpa for 6-48 hr, and pulverizing to 40-100 mesh to obtain lyophilized powder.
The adoption of the further beneficial effects is as follows: the aloe leaf adopts a whole leaf freeze-drying mode, so that the problems of deterioration and unstable color of colloid components and peculiar glycoside components of aloe in the extraction process are avoided, the obtained freeze-dried powder is ensured to be light yellow, the influence on the properties of finished products caused by the addition of subsequent preparations is avoided, and the effective addition amount is ensured.
Further, in the step (5), the concentrated solution obtained in the step (2) and the concentrated solution obtained in the step (3) and the freeze-dried powder obtained in the step (4) are subjected to ultrasonic treatment for 2-60 minutes at 10-80KHz, the ultrasonic treatment is carried out on a macroporous resin column, the ethanol with the volume concentration of 20% -90% is used for elution, and the eluates are combined and dried to obtain the plant antioxidant composition containing the pseudo-ginseng.
The invention also provides application of the plant antioxidant composition containing pseudo-ginseng in preparation of plant antioxidant daily chemical products.
Further, the daily chemical product is any one of face cleaning foam, face cleaning gel, face cleaning milk, essence spray, essence water, mask cream, mask liquid and skin care milk.
Furthermore, the weight ratio of the plant antioxidant composition containing pseudo-ginseng in the plant antioxidant daily chemical product is 0.001-10%.
The adoption of the further beneficial effects is as follows: within the weight ratio range, the prepared plant antioxidant composition containing pseudo-ginseng basically meets the requirements of related preparations in terms of color, solubility, particle size, pH value and other property indexes, and the obtained daily chemical products meet the requirements in terms of appearance property, stability and the like.
Preferably, the weight ratio of the plant antioxidant composition containing pseudo-ginseng in the plant antioxidant daily chemical product is 1.5%.
The preferable beneficial effects are as follows: the plant oxidation-resistant daily chemical product prepared by the weight ratio has the advantages of optimal properties such as appearance and properties, pleasant visual perception of color and smell, and removal effect on various free radicals, and is the optimal addition amount.
The invention also provides a plant antioxidant daily chemical product which is prepared from the following raw materials in parts by weight: 0.001-10 parts of the plant antioxidant composition containing pseudo-ginseng, 0-30 parts of fatty acid, 0-20 parts of pH regulator, 0-50 parts of skin cleaning agent, 0.01-30 parts of skin care agent, 0.01-5 parts of grease, 1-40 parts of cosolvent, 0.001-10 parts of viscosity regulator, 0-10 parts of osmotic pressure regulator, 0.05-5 parts of preservative, 0-30 parts of propellant, 0-5 parts of essence, 0-10 parts of plant essential oil and 5-65 parts of water, wherein the skin care agent is an oily skin care agent and/or a water-based skin care agent.
The invention has the beneficial effects that: by adopting the component proportion, the antioxidant daily chemical products such as face cleaning foam, face cleaning gel, face cleaning milk, essence liquid, essence spray, essence water, mask cream, mask liquid, skin care milk and the like which meet the forming effect and quality requirements of the preparation can be prepared.
Further, the fatty acid is one or more of myristic acid, lauric acid, palmitic acid and stearic acid;
the pH regulator is one or more of potassium hydroxide, sodium hydroxide, citric acid, triethanolamine, sodium glycerophosphate, phosphoric acid and phosphate;
the skin cleanser is one or a mixture of more of sodium laureth sulfate, cocamidopropyl betaine, dodecyl dimethyl betaine, disodium laureth sulfosuccinate, sodium N-lauroyl sarcosinate, disodium sulfosuccinate monoester, disodium laureth sulfosuccinate, ceteth-20, disodium cocoyl amphodiacetate, potassium cocoyl fatty acid glycinate, sodium cocoyl glutamate, cocoyl diethanolamide, PEG-120 methyl glucose dioleate, APG-2000 alkyl glycoside, cocoyl methyl monoethanolamide and dioctyl sodium sulfosuccinate;
the oily skin care agent is one or a mixture of more of diisostearyl malate, myristyl myristate, olive oil PEG-7 esters, isomeric dodecane, isomeric hexadecane, isopropyl palmitate, polyglycerol oleate, polyglycerol fatty acid ester, polyethylene glycol-7 stearate, polyethylene glycol glyceryl oleate, cetearyl glucoside, glycerol polyethylene glycol-75 stearate, glyceryl distearate, caprylic/capric polyethylene glycol glyceride, C12-15 alcohol benzoate, stearate, polyglycerol-3-diisostearate, PEG-8 beeswax, isotridecanol isononanoate and polydimethylsiloxane;
the aqueous skin care agent is one or a mixture of more of sorbitol, sodium hyaluronate, hydrogenated lecithin, ceramide, trehalose, an amino acid humectant, nicotinamide, plant polypeptide, mineral water, mineral powder and allantoin;
the oil is one or more of golden jojoba oil, turpentine oil, water-soluble lanolin, palm oil, coconut oil, nut oil, castor oil, rapeseed oil, sunflower seed oil, ginseng seed oil, prinsepia utilis royle oil, sea buckthorn oil, eucalyptus oil, corn oil, shea butter, avocado oil, basil oil, pine seed oil, chinaberry tree oil, quassia seed oil, sweet almond oil, safflower seed oil, grape seed oil, olive oil, peppermint oil, camellia seed oil, rosemary oil and vaseline;
the cosolvent is one or more of glycerol, polyethylene glycol, propylene glycol, butanediol, diethylene glycol monoethyl ether, hexanediol, polysorbate, ethanol, poloxamer, and carbomer;
the viscosity regulator is one or more of acrylic copolymer, acrylate copolymer, gelatin, sodium chloride, polyoxyethylene hydrogenated castor oil, polyquaternium, guar gum, xanthan gum, sodium carboxymethylcellulose, polyacrylamide, polysorbate-80, sorbitan fatty acid ester, chitosan, 638 thickener, coconut oil diethanolamide, and carbomer;
the osmotic pressure regulator is one or more of sodium chloride, mannitol, glucose, proline, glycine and taurine;
the antiseptic is one or more of caprylyl hydroximic acid, imidazoline, ethylhexyl glycerol, hydroxyethyl urea, and methyl chloroisothiazolinone;
the propellant is one or a mixture of more of carbon dioxide, nitrogen, isobutane, isopentane, propane and butane, trichloromonofluoromethane, difluoromethane, trichlorotetrafluoroethane and nitrous oxide;
the plant essential oil is one or more of tea tree essential oil, oleum Lavandula Angustifolia, oleum Rosae Rugosae, flos Pruni mume essential oil, notoginseng radix essential oil, and herba Menthae essential oil.
The adoption of the further beneficial effects is as follows: except that the plant antioxidant composition containing the pseudo-ginseng is a characteristic ingredient of the invention, the raw materials such as fatty acid, pH regulator, skin cleanser, skin care agent, grease, cosolvent, viscosity regulator, osmotic pressure regulator, preservative, propellant, essence, plant essential oil and the like used for preparing the plant antioxidant daily chemical product are all selected to be most matched with the plant antioxidant composition containing the pseudo-ginseng, so that the antioxidant effect of the composition is not influenced, and meanwhile, the screening is clear, and the stability of the daily chemical product is not influenced by interaction among the raw material components.
The invention also provides a preparation method of the plant antioxidant daily chemical product, which comprises the following steps:
1) Weighing the raw materials according to the plant antioxidant daily chemical product;
2) Heating fatty acid to completely melt, adding pH regulator and water, stirring, adding antioxidant plant composition containing Notoginseng radix and cosolvent, mixing, adding skin care agent, oil, skin cleanser, viscosity regulator, antiseptic, essence or plant essential oil, pressing into liquid propellant, and mixing to obtain antioxidant plant face cleaning foam, face cleaning gel or face cleaning cream;
or mixing Notoginseng radix-containing plant antioxidant composition, skin caring agent, oil and cosolvent, heating, stirring, adding water, stopping heating, stirring, adding pH regulator, viscosity regulator, antiseptic, essence or plant essential oil, pressing liquid propellant, and mixing to obtain plant antioxidant essence, essence spray or essence water;
or, stirring the viscosity regulator and water, adding the pH regulator, mixing until the mixture is clear and transparent, adding the osmotic pressure regulator, and mixing uniformly to obtain a stable solution for later use; mixing and dissolving a plant antioxidant composition containing pseudo-ginseng, a skin care agent, grease and a cosolvent, adding the mixture into a stable solution, stirring, adding a preservative, essence or plant essential oil, and uniformly mixing to obtain a plant antioxidant mask paste or mask liquid;
or mixing oil and oily skin caring agent, heating, stirring for dissolving, mixing plant antioxidant composition containing Notoginseng radix, water-based skin caring agent, cosolvent, viscosity regulator and water for dissolving, adding into oil and oily skin caring agent, heating, stirring, adding antiseptic, essence or plant essential oil, stopping heating, and stirring to obtain plant antioxidant skin caring emulsion.
Further, in the step 2), heating the fatty acid to be completely melted, adding the pH regulator and water, stirring at the temperature of 40-90 ℃ and the rotating speed of 10-500r/min for 15-120min, then adding the plant antioxidant composition containing pseudo-ginseng and the cosolvent, uniformly mixing, adding the skin care agent, the grease, the skin cleaning agent, the viscosity regulator, the preservative, the essence or the plant essential oil, pressing the liquid propellant, and uniformly mixing to obtain the plant antioxidant cleansing foam, the cleansing gel or the cleansing milk.
Adopt above-mentioned further beneficial effect to be: the prepared face cleaning product has white and fine foam, is uniform, lasting and not loose, can achieve a good cleaning effect with a small using amount, controls the pH value of the product, and simultaneously reduces the damage of the face cleaning product to the skin by adding a skin care agent and high-quality grease suitable for the skin.
Further, in the step 2), the plant antioxidant composition containing pseudo-ginseng, the skin care agent, the grease and the cosolvent are mixed and heated to 20-60 ℃, the stirring is carried out for 1-60min at the rotating speed of 10-500r/min, the water is added, the heating is stopped, the stirring is continued for 1-60min, then the pH regulator, the viscosity regulator, the preservative, the essence or the plant essential oil are added, the liquid propellant is pressed, and the mixture is uniformly mixed, so that the plant antioxidant essence, the essence spray or the essence water is obtained.
The adoption of the further beneficial effects is as follows: the plant antioxidant essence spray has good atomization effect, is sprayed on the face without water drop-shaped aggregation and flowing, is uniformly and rapidly absorbed, can quickly enter the skin to achieve the antioxidant effect, delays cell aging, has the best effect, is convenient and rapid to use, and can resist and repair the damage caused by oxidation to human epidermal fibroblasts anytime and anywhere.
Further, in the step 2), stirring the viscosity regulator and water at the rotating speed of 50-1000r/min for 5-30min, adding the pH regulator, mixing until the mixture is clear and transparent, adding the osmotic pressure regulator, and uniformly mixing to obtain a stable solution for later use; mixing and dissolving the plant antioxidant composition containing pseudo-ginseng, the skin care agent, the grease and the cosolvent, adding the mixture into the stable solution, stirring for 1-120min at the rotating speed of 10-500r/min, adding the preservative, the essence or the plant essential oil, and uniformly mixing to obtain the plant antioxidant mask paste or the mask liquid.
The adoption of the further beneficial effects is as follows: the plant antioxidant mask product is light in color, clear and transparent, has no stimulation and burden on skin, is soft and comfortable in use, does not flow, has no bad feelings of stickiness, discomfort, oily light return and the like after being removed, and can restore the redox balance in the skin while removing various free radicals.
Further, in the step (2), mixing and heating the grease and the oily skin care agent to 30-100 ℃, stirring and dissolving at 10-500r/min, mixing and dissolving the plant antioxidant composition containing the pseudo-ginseng, the aqueous skin care agent, the cosolvent, the viscosity regulator and the water, adding the mixture into the grease and the oily skin care agent, heating to 30-100 ℃, stirring at the rotating speed of 0.02-0.08Mpa and 2000-8000r/min in vacuum for 1-60min, adding the preservative, the essence or the plant essential oil, stopping heating, and conventionally stirring at the rotating speed of 10-500r/min until cooling to obtain the plant antioxidant skin care emulsion.
The adoption of the further beneficial effects is as follows: the plant antioxidant skin care product can remove various oxygen free radicals, resist aging caused by oxidation, deeply moisten for a long time, and has uniform emulsion droplet particle size, fine and stable texture, no greasy feeling or skin irritation in the using process, and suitability for use in various seasons.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of the plant antioxidant facial cleanser comprises the following steps:
(1) Weighing 25g of fresh panax notoginseng freeze-dried tablets, 25g of giant knotweed, 25g of white plum blossom and 25g of aloe leaves;
(2) Adding 30% ethanol into fresh radix Notoginseng lyophilized tablet, heating to 80 deg.C, reflux extracting for 2 times with solvent 8 times of the raw material each time for 120min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 0.8 g crude drug per gram;
(3) Respectively crushing giant knotweed rhizome and white plum blossom to 10 meshes, adding ethanol with volume concentration of 70%, heating to 60 ℃, performing reflux extraction for 2 times, adopting a solvent with the mass of 8 times of that of the raw material each time, wherein the extraction time is 120 minutes, filtering the extracting solution, and concentrating to obtain a concentrated solution containing 0.8 g of crude drug per gram for later use;
(4) Cutting folium Aloe into 1cm 3 Freeze drying the small blocks at-80 deg.C under 0.06Mpa for 24 hr, and pulverizing to 60 mesh to obtain lyophilized powder;
(5) Carrying out ultrasonic treatment on the concentrated solution obtained in the steps (2) and (3) and the freeze-dried powder obtained in the step (4) for 20 minutes at 50KHz, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 50%, combining eluates, and drying to obtain a plant antioxidant composition containing pseudo-ginseng;
(6) Weighing 8 g of myristic acid, 8 g of lauric acid, 8 g of stearic acid, 6 g of sodium hydroxide, 0.005 g of pseudo-ginseng-containing plant antioxidant composition, 8 g of glycerol, 10 g of propylene glycol, 0.1 g of vaseline, 0.05 g of trehalose, 5g of disodium cocoyl amphodiacetate, 10 g of APG-2000 alkyl glycoside, 8 g of oleic acid polyethylene glycol glyceride, 1g of glyceryl distearate, 2 g of amino acid humectant, 390.3 g of polyquaternium-0.5 g of hydroxyethyl urea, 1g of essence and 24.045 g of water;
(7) Heating myristic acid, lauric acid and stearic acid to be completely melted, adding sodium hydroxide and water at the temperature of 60 ℃, stirring for 90min at the speed of 400r/min, then adding the plant antioxidant composition containing pseudo-ginseng, glycerol and propylene glycol, uniformly mixing, then adding vaseline, trehalose, disodium cocoyl amphodiacetate, APG-2000 alkyl glycoside, polyethylene glycol oleate, glyceryl distearate, an amino acid humectant, polyquaternium-39, hydroxyethyl urea and essence, and uniformly mixing to obtain the product.
Example 2
A preparation method of plant antioxidant cleansing foam comprises the following steps:
(1) Weighing 40 g of fresh panax notoginseng freeze-dried tablets, 40 g of giant knotweed, 15 g of white plum blossom and 5g of aloe leaves;
(2) Adding 30% ethanol into fresh radix Notoginseng lyophilized tablet, heating to 80 deg.C, reflux extracting for 2 times with solvent 8 times of the raw material each time for 120min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 0.8 g crude drug per gram;
(3) Respectively crushing giant knotweed rhizome and white plum blossom to 10 meshes, adding ethanol with volume concentration of 70%, heating to 60 ℃, performing reflux extraction for 2 times, adopting a solvent with the mass of 8 times of that of the raw material each time, wherein the extraction time is 120 minutes, filtering the extracting solution, and concentrating to obtain a concentrated solution containing 0.8 g of crude drug per gram for later use;
(4) Cutting folium Aloe into 1cm 3 Freeze-drying the small blocks at-80 deg.C under 0.06Mpa for 24 hr, and pulverizing to 60 mesh to obtain lyophilized powder;
(5) Carrying out 40KHz ultrasonic treatment on the concentrated solution obtained in the step (2) and the concentrated solution obtained in the step (3) and the freeze-dried powder obtained in the step (4) for 40 minutes, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 70%, merging eluent, and drying to obtain the plant antioxidant composition containing pseudo-ginseng;
(6) Weighing 3 g of myristic acid, 3 g of lauric acid, 3 g of stearic acid, 2 g of potassium hydroxide, 0.1 g of pseudo-ginseng-containing plant antioxidant composition, 5g of glycerin, 3 g of propylene glycol, 800.5 g of polysorbate-800.5 g of cocamide betaine, 4 g of cocoyl amphodiacetate, 8 g of disodium laureth sulfosuccinate, 7 g of olive oil PEG-7 esters, 3 g of isotridecanol isononanoate, 5g of polyoxyethylene hydrogenated castor oil, 0.085 g of methyl chloroisothiazolinone, 0.015 g of iodopropynyl butylcarbamate, 0.5 g of essence, 19.8 g of water and 10 g of liquid isobutane;
(7) Heating myristic acid, lauric acid and stearic acid to completely melt, adding potassium hydroxide and water, stirring at the temperature of 80 ℃ for 60min at the speed of 500r/min, then adding the plant antioxidant composition containing pseudo-ginseng, glycerol, propylene glycol and polysorbate-80, uniformly mixing, then adding cocoamidobetaine, disodium cocoamphodiacetate, disodium laureth sulfosuccinate, olive oil PEG-7 esters, isotridecanol isononanoate, polyoxyethylene hydrogenated castor oil, methyl chloroisothiazolinone, iodopropynyl butyl carbamate, essence and water, pressing liquid isobutane, and uniformly mixing to obtain the product.
Example 3
A preparation method of plant antioxidant essence water comprises the following steps:
(1) Weighing 0.1 g of fresh panax notoginseng freeze-dried tablets, 0.1 g of giant knotweed rhizome, 40 g of white plum blossom and 59.8 g of aloe leaves;
(2) Adding 70% ethanol into fresh radix Notoginseng lyophilized tablet, heating to 50 deg.C, reflux extracting for 1 time with solvent 20 times the weight of raw materials for 30min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 0.2 g crude drug per gram;
pulverizing rhizoma Polygoni Cuspidati and flos Pruni mume to 5 mesh, adding 30% ethanol, heating to 85 deg.C, reflux-extracting for 1 time with solvent 20 times the weight of the raw materials for 30min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 0.2 g crude drug per gram;
(3) Cutting folium Aloe into 1cm 3 Freeze drying the small blocks at-40 deg.C under 0.02Mpa for 18 hr, and pulverizing to 40 mesh to obtain lyophilized powder;
(4) Carrying out 80KHz ultrasonic treatment on the concentrated solution obtained in the step (2) and the freeze-dried powder obtained in the step (3) for 5 minutes, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 80%, merging eluent, and drying to obtain the plant antioxidant composition containing pseudo-ginseng;
(5) Weighing 5g of a plant antioxidant composition containing pseudo-ginseng, 2 g of sorbitol, 0.5 g of nicotinamide, 0.05 g of isopropyl palmitate, 0.01 g of polydimethylsiloxane, 10 g of diethylene glycol monoethyl ether, 10 g of ethanol, 602 g of polysorbate, 0.05 g of citric acid, 0.8 g of guar gum, 0.1 g of sodium benzoate, 0.5 g of tea tree essential oil, 5g of liquid carbon dioxide and 63.99 g of water;
(6) Mixing and heating a plant antioxidant composition containing pseudo-ginseng, sorbitol, nicotinamide, isopropyl palmitate, polydimethylsiloxane, diethylene glycol monoethyl ether, ethanol and polysorbate 60 to 50 ℃, stirring for 20min at the rotating speed of 100r/min, adding water, stopping heating, continuing stirring for 20min, then adding citric acid, guar gum, sodium benzoate and tea tree essential oil, pressing liquid carbon dioxide, and uniformly mixing to obtain the product.
Example 4
A preparation method of a plant antioxidant skin care milk comprises the following steps:
(1) Weighing 40 g of fresh panax notoginseng freeze-dried tablets, 10 g of giant knotweed, 40 g of white plum blossom and 10 g of aloe leaves;
(2) Adding ethanol with volume concentration of 10% into fresh radix Notoginseng lyophilized tablet, heating to 90 deg.C, reflux-extracting for 2 times with solvent 10 times of the raw material each time for 90min, filtering the extractive solution, and concentrating to obtain concentrated solution containing crude drug 0.5 g per gram for use;
pulverizing rhizoma Polygoni Cuspidati and flos Pruni mume to 15 mesh, adding 80% ethanol, heating to 45 deg.C, reflux-extracting for 2 times with solvent 10 times the weight of the raw materials for 90min, filtering the extractive solution, and concentrating to obtain concentrated solution containing crude drug 0.5 g per gram;
(3) Cutting folium Aloe into 1cm 3 Freeze drying the small blocks at-90 deg.C under 0.1Mpa for 6 hr, and pulverizing to 80 mesh to obtain lyophilized powder;
(4) Carrying out 10KHz ultrasonic treatment on the concentrated solution obtained in the step (2) and the freeze-dried powder obtained in the step (3) for 60 minutes, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 40%, merging eluent, and drying to obtain the plant antioxidant composition containing pseudo-ginseng;
(5) Weighing 1g of golden jojoba oil, 1g of isododecane, 0.5 g of eucalyptus oil, 3 g of myristyl myristate, 3 g of isopropyl palmitate, 8 g of polyglycerol oleate, 5g of caprylic/capric polyethylene glycol glyceride, 8 g of a plant antioxidant composition containing pseudo-ginseng, 1g of plant polypeptide, 0.001 g of carbomer, 4005 g of polyethylene glycol, 8 g of butanediol, 50.999 g of water, 0.5 g of caprylyl hydroximic acid and 5g of rose essential oil;
(6) Mixing and heating golden jojoba oil, isododecane, eucalyptus oil, myristyl myristate, isopropyl palmitate, polyglycerol oleate and caprylic/capric acid polyethylene glycol glyceride to 60 ℃, stirring and dissolving, mixing and dissolving a plant antioxidant composition containing pseudo-ginseng, plant polypeptide, carbomer, polyethylene glycol 400, butanediol and water, adding the mixture into the grease and the oily skin care agent, heating to 60 ℃, stirring at the rotating speed of 0.04mpa and 4000r/min in vacuum for 5min, adding caprylyl hydroximic acid and rose essential oil, stopping heating, and conventionally stirring at the rotating speed of 400r/min to cool to obtain the product.
Example 5
A preparation method of plant antioxidant essence spray comprises the following steps:
(1) Preparing a plant antioxidant composition containing notoginseng by the same method as example 2;
(2) Weighing 1.5 g of a plant antioxidant composition containing pseudo-ginseng, 5g of water-soluble ceramide, 0.1 g of hydrogenated lecithin, 1g of shea butter, 7 g of caprylic capric polyethylene glycol glyceride, 10 g of propylene glycol, 0.01 g of citric acid, 0.805 g of polysorbate-805, 0.05 g of ethylhexyl glycerol, 0.15 g of phenoxyethanol, 0.03 g of essence, 15 g of liquid nitrogen and 55.16 g of water;
(3) Mixing and heating a plant antioxidant composition containing pseudo-ginseng, water-soluble ceramide, hydrogenated lecithin, shea butter, caprylic/capric macrogol glyceride and propylene glycol to 40 ℃, stirring for 30min at the rotating speed of 500r/min, adding water, stopping heating, continuing stirring for 60min, then adding citric acid, polysorbate-80, ethylhexyl glycerol, phenoxyethanol and essence, pressing liquid nitrogen, and uniformly mixing to obtain the product.
Example 6
A preparation method of plant antioxidant essence comprises the following steps:
(1) Weighing 30 g of fresh panax notoginseng freeze-dried tablets, 30 g of giant knotweed, 30 g of white plum blossom and 10 g of aloe leaves;
(2) Adding 20% ethanol into fresh radix Notoginseng lyophilized tablet, heating to 85 deg.C, reflux extracting for 2 times with solvent 15 times of the raw materials each time for 150 min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 1.0 g crude drug per gram;
pulverizing rhizoma Polygoni Cuspidati and flos Pruni mume to 20 mesh, adding 60% ethanol, heating to 65 deg.C, reflux-extracting for 2 times, each time using 15 times of solvent, extracting for 150 min, filtering the extractive solution, and concentrating to obtain concentrated solution containing 1.0 g crude drug per gram;
(3) Cutting folium Aloe into 1cm 3 Freeze-drying the small blocks at-65 deg.C under 0.06Mpa for 36 hr, and pulverizing to 50 mesh to obtain lyophilized powder;
(4) Carrying out 30KHz ultrasonic treatment on the concentrated solution obtained in the step (2) and the freeze-dried powder obtained in the step (3) for 30 minutes, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 70%, merging eluent, and drying to obtain the plant antioxidant composition containing pseudo-ginseng;
(5) Weighing 3 g of a plant antioxidant composition containing pseudo-ginseng, 0.5 g of sodium hyaluronate, 0.5 g of nicotinamide, 0.5 g of shea butter, 10 g of diethylene glycol monoethyl ether, 10 g of glycerol, 5g of poloxamer mixture, 1g of coconut oil diethanolamide, 0.08 g of imidazoline, 0.1 g of plum blossom essential oil, 8 g of liquid propane and butane and 61.32 g of water;
(6) Mixing and heating the plant antioxidant composition containing pseudo-ginseng, sodium hyaluronate, nicotinamide, shea butter, diethylene glycol monoethyl ether, glycerol and poloxamer to 30 ℃, stirring for 60min at the rotating speed of 50r/min, adding water, stopping heating, continuing stirring for 60min, then adding coconut oil diethanolamide, imidazolines and plum blossom essential oil, pressing liquid propane and butane, and uniformly mixing to obtain the product.
Example 7
A preparation method of plant antioxidant skin care milk comprises the following steps:
(1) A plant antioxidant composition containing notoginseng was prepared in the same manner as in example 2.
(2) Weighing 3 g of grape seed oil, 2 g of prinsepia utilis royle oil, 5g of shea butter, 1g of C12-15 alcohol benzoate, 3 g of glycerol polyethylene glycol-75-stearate, 0.5 g of isomeric hexadecane, 1g of polyglycerol fatty acid ester, 0.5 g of polyglycerol-3-diisostearate, 0.3 g of diisostearyl malate, 0.2 g of polydimethylsiloxane, 8 g of a plant antioxidant composition containing pseudo-ginseng, 15 g of propylene glycol, 3 g of sodium hyaluronate, 2 g of hydrogenated lecithin, 0.2 g of carbomer, 54.9 g of water, 0.3 g of methylparaben and 0.1 g of essence.
(3) Mixing grape seed oil, prinsepia utilis royle oil, shea butter, C12-15 alcohol benzoate, glycerol polyethylene glycol-75-stearate, isomeric hexadecane, polyglycerol fatty acid ester, polyglycerol-3-diisostearate, diisostearyl malate and polydimethylsiloxane, heating to 85 ℃, stirring for dissolving, mixing and dissolving the plant antioxidant composition containing pseudo-ginseng, propylene glycol, sodium hyaluronate, hydrogenated lecithin, carbomer and water, adding the mixture into the grease and the oily skin care agent, heating to 80 ℃, stirring for 60min at the rotating speed of 0.06Mpa and 6000r/min in vacuum, adding methylparaben and essence, stopping heating, and conventionally stirring at the rotating speed of 10-500r/min for cooling to obtain the product.
The efficacy test of the plant antioxidant composition containing the pseudo-ginseng and the daily chemical product prepared by using the same comprises the following steps:
1. DPPH free radical scavenging, ABTS free radical scavenging, superoxide anion free radical scavenging and hydroxyl free radical scavenging experiments of a plant antioxidant composition containing pseudo-ginseng and a preparation thereof are as follows:
1. the experimental method comprises the following steps:
1.1 DPPH free radical scavenging experiment
The experiment was performed by absorptiometry. Samples were added to a 96-well plate, 3 replicate wells were set, 2 dilution gradients per sample, 10-fold dilution was performed (4 dilution gradients per sample after primary screening if the sample had significant DPPH free radical scavenging effect, 2-fold dilution was performed for replicate wells), 100 μ L per well, and 100 μ L of 0.1mdpph per well. Negative control antioxidant group without plantA sample of the formulation of compound, blank, was prepared using 50% ethanol instead of DPPH, and the procedure was otherwise identical. The reaction solution was mixed well and incubated for 30 minutes at room temperature in the dark. And reading the absorbance value at 517nm by using a microplate reader, wherein the lower the delta OD value is, the higher the scavenging activity of the sample on free radicals is. Calculation of DPPH radical scavenging Rate and IC 50 。
1.2ABTS free radical scavenging experiments
The experiment was performed by absorptiometry. The samples were added to a 96-well plate, 3 replicate wells were set, 2 dilution gradients per sample, 10-fold dilution was performed (4 dilution gradients per sample after primary screening if the samples had significant ABTS free radical scavenging, 2-fold dilution was performed for replicate wells), 100 μ L per well, and 100 μ L of 0.1mabts per well. Negative control samples of the formulation without the plant antioxidant composition and blank control sample ABTS with 50% ethanol were used, and the rest of the procedure was the same. The reaction solution was mixed well and incubated for 30 minutes at room temperature in the dark. When the absorbance value of 734nm is read by a microplate reader, the lower the delta OD value is, the higher the scavenging activity of the sample to free radicals is. Calculation of ABTS free radical clearance and IC 50 。
1.3 superoxide anion radical scavenging experiments
The experiment was performed by absorptiometry. Adding samples into a 96-well plate, setting 3 multiple wells, setting 4 dilution gradients for each sample, carrying out 2-fold dilution, carrying out 100 mu L per well, and carrying out detection according to the instructions of the superoxide anion free radical determination kit.
1.4 hydroxy radical scavenging experiments
The experiment was performed by absorptiometry. Adding samples into a 96-well plate, setting 3 multiple wells, setting 4 dilution gradients for each sample, carrying out 2-fold dilution, 100 mu L of each well, and detecting according to the specification of a hydroxyl radical determination kit.
2. Experimental materials:
trolox (Sigma, cat # 238813-1G, lot # BCBP 2767V), DPPH (Sigma, cat # D9132-1G, lot # STBF 5255V), ABTS (Sigma, cat # A1888-1G, lot # SLBN 7932V), hydroxyl radical assay kit, superoxide anion assay kit, K2S2O8 (Sigma, cat # P112194-25G, lot # F1508005), sodium dihydrogen phosphate (West Longkao chemical Co., ltd., lot # 1202011), disodium hydrogen phosphate (West Longkao chemical Co., lot # 111021), anhydrous ethanol (Lianlong Bo (Tianjin) Med. Co., ltd., lot # D4540-100, lot # 20155), DMSO (in the final reaction system, volume fraction of DMSO < 1%), multiplexskrmsromno plate reader (Therom scales), PRTOR ACT-1 CN (Sa TM) (RTM Biocal instruments), thermo-Mass Spectrometer (SAUM) (Med Biocal instruments) (GnMp 9270), and Suzu instruments (Skino-20), and Summy instruments).
3. The experimental results are as follows:
TABLE 1 Table of four free radical scavenging effect results of different extracts and preparations
The results show that: after the plant antioxidant composition containing pseudo-ginseng is extracted, mixed and refined through a column, DPPH free radical scavenging, ABTS free radical scavenging, superoxide anion free radical scavenging and hydroxyl free radical scavenging effects are optimal; the plant antioxidant cleansing foam, the plant antioxidant essence spray and the plant antioxidant skin care milk prepared by the composition have the function of removing free radicals in 3 preparations.
2. A cell level antioxidant and antiaging effect experiment of antioxidant composition and preparation of plant containing Notoginseng radix comprises:
1. the experimental method comprises the following steps:
1.1 cellular level antioxidant Activity Studies
1.1.1 cell culture
Selecting subcultured HFF-1 cells (human epidermal fibroblasts), digesting with 0.25% trypsin, passaging with DMEM high-glucose medium containing 10% fetal bovine serum, incubating at 37 deg.C, and removing 5% CO 2 Culturing in an incubator in a saturated humidity environment. The medium was changed once every 2 days, and each experiment was taken from the same passage cell.
1.1.2 H 2 O 2 Establishment of HFF-1 cell oxidative damage induction model
When the cells grow to 80% -90%, digesting the cells into single cells by using 0.25% of pancreatin, and adjusting the cell density to 1 × 10 5 100. Mu.L per well per ml were inoculated into 96-well plates, the plates were incubated at 37 ℃ and 5% CO 2 Culturing in an incubator for 24h. The experiment was divided into a blank control group and a model group. Adding 100 mu of LDMEM culture solution into each hole of the blank control group; model group: mixing 30% of H 2 O 2 Dilution with DMEM medium to different concentrations: 500 The molding concentration was determined by measuring the cell viability by the MTT method 6h after HUVEC cells were treated with 100. Mu.L/well of 600, 700, 800, 900, 1000, 1100, 1200. Mu.M. Each concentration paralleled 3 wells.
1.1.3 investigation of the safe concentration of test samples on HUVEC cells
HFF-1 cells were plated at 1.0X 10 5 Inoculating to 96-well cell culture plate (100. Mu.L per well) at a concentration of one/mL, incubating at 37 ℃ and 5% 2 Culturing in an incubator in a saturated humidity environment for 24h. The supernatant was discarded, and test samples of different concentrations were added, and a corresponding volume of culture medium was added to the blank control. 3 parallel wells were set for each concentration. At 37 ℃ C, 5% CO 2 Culturing in an incubator in a saturated humidity environment for 24h. Adding MTT solution, 37 ℃,5% CO 2 Incubate for 4h in the incubator, terminate incubation, aspirate the supernatant from the wells, add DMSO to dissolve the purple crystals. In thatThe absorbance OD value of each well (OD value is proportional to the number of living cells) is measured on a continuous wavelength microplate reader (570 nm wavelength). Cell viability was calculated according to the formula: cell viability (%) = experimental OD value/blank OD value × 100%.
1.1.4 Effect of test samples on GSH, MDA content and SOD activity in HFF-1 cells damaged by oxidation
HFF-1 cells were plated at 1.0X 10 5 Cell culture plates (2000. Mu.L per well) were seeded at a concentration of cells/mL, incubated at 37 ℃,5% 2 Incubate in incubator for 24h. The experiment is divided into a blank control group, a model group, a positive control group, a negative control group and a tested sample group. Discarding cell supernatant, adding 2000 μ L of LDMEM culture medium to each well of blank control group, and adding 2000 μ L of H-containing medium to each well of other groups 2 O 2 The culture solution of (4) was incubated at 37 ℃ and 5% CO 2 Culturing in an incubator for 6h. Discarding the supernatant, and adding 2000 μ of LDMEM culture solution into each hole of the blank control group and the model group; 2000. Mu.L of DMEM culture solution containing samples at corresponding concentrations were added to each of the positive control group, the negative control group and the test sample group, and applied to HFF-1 cells for 24 hours. Removing supernatant, washing cells twice with PBS, adding 200 μ L pure water into each well, repeatedly freezing and thawing at-80 deg.C for 4 times to lyse cells, and determining GSH, MDA content and SOD activity in cells with GSH, MDA and SOD kit. Each concentration paralleled 3 wells.
1.2 cell-level anti-aging Activity Studies
1.2.1 Effect of test samples on HFF-1 proliferative Activity
HFF-1 cells were plated at 1.0X 10 5 Cell lines/mL were plated in 96-well cell culture plates (100. Mu.L per well) at 37 ℃ and 5% CO 2 Culturing in an incubator in a saturated humidity environment for 24h. The supernatant was discarded, and test samples of different concentrations were added, and a corresponding volume of culture medium was added to the blank control. 3 parallel wells were set for each concentration. At 37 ℃ C, 5% CO 2 Culturing in an incubator in a saturated humidity environment for 24h. Adding MTT solution, 37 ℃,5% CO 2 Incubate 4h in incubator, terminate incubation, aspirate supernatant from wells, add DMSO to dissolve purple crystals. Measuring the absorbance OD value (OD value is proportional to the number of living cells) of each well on a continuous wavelength microplate reader (570 nm wavelength) andand calculating the proliferation rate of the cells.
1.2.2 test sample pairs H 2 O 2 Study of protective Effect of inducing aging of HFF-1 cells
HFF-1 cells were plated at 1.0X 10 5 Cell culture plates (100. Mu.L per well) were seeded at a concentration of one/mL in 96 wells and placed at 37 ℃ 5% 2 Incubate in incubator for 24h. The experiment is divided into a blank control group, a model group, a positive control group, a negative control group and a tested sample group. Discarding cell supernatant, adding 100 μ L of culture medium for blank control group and 100 μ L of H-containing medium for other groups 2 O 2 The culture solution of (4) was incubated at 37 ℃ and 5% CO 2 Culturing in an incubator for 6h. Removing supernatant, and adding 100 μ of LDMEM culture solution into each well of blank control group and model group; the positive control group, the negative control group and the test sample group are added with 100 mu L of DMEM culture solution containing samples with corresponding concentrations respectively to act on the HHF-1 cells for 24h. The cell viability was measured by MTT method and the LDH viability in the supernatant was measured by LDH kit. Each concentration paralleled 3 wells.
2. Experimental materials:
SOD kit, GSH kit, LDH kit, MTT, DMEM high sugar medium, bovine serum, 0.25% pancreatic digest, PBS buffer, K2S2O8 (Sigma, cat # P112194-25G, lot # F1508005), sodium dihydrogen phosphate (West Longgan chemical Co., ltd., lot # 1202011), disodium hydrogen phosphate (West Longga chemical Co., ltd., lot # 111021), JJ2000 type electronic balance (PRACTUM 224-1CN electronic balance, satorus;, shuangjie brother, USA), low temperature high speed centrifuge, multiskANGO enzyme reader (Thermo), GNP-9270 water-proof type constant temperature incubator (Shanghai Macro laboratories Ltd.), 30-300. Mu.L discharge gun (Thermo), and various range liquid transfer guns (Dalong Co.).
3. The experimental results are as follows:
TABLE 2 influence of antioxidant daily chemical containing Notoginseng radix on HFF-1 cell damage, GSH, SOD and LDH
"#" P < 0.05 compared to the blank control group; compared to model group, "" P < 0.05
The results show that: in the preparation prepared from the plant antioxidant composition containing pseudo-ginseng, the plant antioxidant spray and the plant antioxidant skin care milk can obviously reduce the LDH activity of HHF-1 cells damaged by oxidation, and simultaneously increase the SOD and GSH contents of the HHF-1 cells damaged by oxidation and improve the cell survival rate. Wherein the effect of essence is strongest; the plant antioxidant cleansing foam obviously reduces the LDH activity of HHF-1 cells damaged by oxidation only under the concentration of 100 mu g/ml, has no effect as compared with other 2 preparations, and is possibly related to the addition amount of the antioxidant composition.
3. Stability results of antioxidant plant daily chemical products
TABLE 3 accelerated stability results of Notoginseng radix containing plant antioxidant cleansing foam with 40 deg.C RH75%
TABLE 4 table of the accelerated stability results of the spray of antioxidant plant essence containing notoginseng at 40 ℃ RH75%
TABLE 5 Panax notoginseng-containing plant antioxidant skin care cream with 40 deg.C RH75% accelerated stability results in the table
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. A plant antioxidant composition containing pseudo-ginseng is characterized by being prepared from the following raw materials in parts by weight: 0.1-50 parts of fresh panax notoginseng freeze-dried tablets, 0.1-50 parts of giant knotweed, 0.1-50 parts of white plum blossom and 1-60 parts of aloe leaves;
the preparation method of the plant antioxidant composition containing pseudo-ginseng comprises the following steps:
(1) Weighing the raw materials according to the plant antioxidant composition containing the pseudo-ginseng;
(2) Adding ethanol with volume concentration of 5-90% into fresh radix Notoginseng lyophilized tablet, heating to 40-90 deg.C, reflux extracting for 1-3 times with solvent 3-20 times of the raw material each time for 30-180 min, filtering the extractive solution, and concentrating to obtain concentrated solution containing crude drug 0.2-1.2 g per gram for use;
(3) Respectively crushing the giant knotweed rhizome and the white plum blossom into 3-30 meshes, adding ethanol with the volume concentration of 5-90%, heating to 40-90 ℃, performing reflux extraction for 1-3 times, wherein a solvent with the mass of 3-20 times that of the raw material is adopted each time, the extraction time is 30-180 minutes, and filtering and concentrating the extracting solution to obtain a concentrated solution containing 0.2-1.2 g of crude drugs per gram for later use;
(4) Cutting folium Aloe into 1cm 3 Freeze drying the small blocks at-20 deg.C to-90 deg.C under 0.02-0.2Mpa for 6-48 hr, and pulverizing to 40-100 mesh to obtain lyophilized powder;
(5) And (3) carrying out ultrasonic treatment on the concentrated solution obtained in the step (2) and the freeze-dried powder obtained in the step (4) for 2-60 minutes at 10-80KHz, passing through a macroporous resin column, eluting by using ethanol with the volume concentration of 20-90%, merging eluent, and drying to obtain the plant antioxidant composition containing pseudo-ginseng.
2. The plant antioxidant composition containing pseudo-ginseng according to claim 1, which is prepared from the following raw materials in parts by weight: 40 parts of fresh panax notoginseng freeze-dried tablets, 40 parts of giant knotweed, 15 parts of white plum blossom and 5 parts of aloe leaves.
3. Use of the plant antioxidant composition containing notoginseng radix as described in claim 1 or 2 for the preparation of plant antioxidant daily chemical products.
4. The use of the plant antioxidant composition containing notoginseng radix as claimed in claim 3 for preparing plant antioxidant daily chemical products, wherein the daily chemical products are any one of cleansing foam, cleansing gel, cleansing cream, essence spray, essence water, mask cream, mask liquid and skin care cream.
5. The use of the plant antioxidant composition containing notoginseng according to claim 3 for preparing plant antioxidant daily chemical products, wherein the weight ratio of the plant antioxidant composition containing notoginseng in the plant antioxidant daily chemical products is 0.001% -10%.
6. The use of the plant antioxidant composition containing notoginseng radix as described in claim 5 for the preparation of plant antioxidant daily chemical products, wherein the weight ratio of the plant antioxidant composition containing notoginseng radix in the plant antioxidant daily chemical products is 1.5%.
7. A plant oxidation-resistant daily chemical product is characterized by being prepared from the following raw materials in parts by weight: the pseudo-ginseng-containing plant antioxidant composition as claimed in claim 1 or 2, wherein the composition comprises 0.001-10 parts of pseudo-ginseng, 0-30 parts of fatty acid, 0-20 parts of pH regulator, 0-50 parts of skin cleanser, 0.01-30 parts of skin care agent, 0.01-5 parts of grease, 1-40 parts of cosolvent, 0.001-10 parts of viscosity regulator, 0-10 parts of osmotic pressure regulator, 0.05-5 parts of preservative, 0-30 parts of propellant, 0-5 parts of essence, 0-10 parts of plant essential oil and 5-65 parts of water, and the skin care agent is an oily skin care agent and/or a water-based skin care agent.
8. The plant oxidation-resistant daily chemical product according to claim 7, wherein the fatty acid is one or a mixture of myristic acid, lauric acid, palmitic acid and stearic acid;
the pH regulator is one or a mixture of more of potassium hydroxide, sodium hydroxide, citric acid, triethanolamine, sodium glycerophosphate, phosphoric acid and phosphate;
the skin cleanser is one or a mixture of more of sodium laureth sulfate, cocamidopropyl betaine, dodecyl dimethyl betaine, disodium laureth sulfosuccinate, sodium N-lauroyl sarcosinate, disodium sulfosuccinate monoester, disodium laureth sulfosuccinate, ceteth-20, disodium cocoyl amphodiacetate, potassium cocoyl fatty acid glycinate, sodium cocoyl glutamate, cocoyl diethanolamide, PEG-120 methyl glucose dioleate, APG-2000 alkyl glycoside, cocoyl methyl monoethanolamide and dioctyl sodium sulfosuccinate;
the oily skin care agent is one or a mixture of more of diisostearyl malate, myristyl myristate, olive oil PEG-7 esters, isomeric dodecane, isomeric hexadecane, isopropyl palmitate, polyglycerol oleate, polyglycerol fatty acid ester, polyethylene glycol-7 stearate, polyethylene glycol glyceryl oleate, cetearyl glucoside, glycerol polyethylene glycol-75 stearate, glyceryl distearate, caprylic/capric polyethylene glycol glyceride, C12-15 alcohol benzoate, stearate, polyglycerol-3-diisostearate, PEG-8 beeswax, isotridecanol isononanoate and polydimethylsiloxane;
the aqueous skin care agent is one or a mixture of more of sorbitol, sodium hyaluronate, hydrogenated lecithin, ceramide, trehalose, an amino acid humectant, nicotinamide, plant polypeptide, mineral water, mineral powder and allantoin;
the oil is one or a mixture of more of golden jojoba oil, turpentine oil, water-soluble lanolin, palm oil, coconut oil, nut oil, castor oil, rapeseed oil, sunflower seed oil, ginseng seed oil, prinsepia utilis royle oil, sea buckthorn oil, eucalyptus oil, corn oil, shea butter, avocado oil, basil oil, pine seed oil, chinaberry tree oil, quassia seed oil, sweet almond oil, safflower seed oil, grape seed oil, olive oil, peppermint oil, camellia seed oil, rosemary oil and vaseline;
the cosolvent is one or a mixture of more of glycerol, polyethylene glycol, propylene glycol, butanediol, diethylene glycol monoethyl ether, hexanediol, polysorbate, ethanol, poloxamer and carbomer;
the viscosity regulator is one or a mixture of more of acrylic copolymer, acrylate copolymer, gelatin, sodium chloride, polyoxyethylene hydrogenated castor oil, polyquaternium, guar gum, xanthan gum, sodium carboxymethyl cellulose, polyacrylamide, polysorbate, sorbitan fatty acid ester, chitosan, 638 thickening agent, coconut oil diethanolamide and carbomer;
the osmotic pressure regulator is one or a mixture of more of sodium chloride, mannitol, glucose, proline, glycine and taurine;
the preservative is one or a mixture of more of caprylyl hydroximic acid, imidazolines, ethylhexyl glycerol, hydroxyethyl urea and methyl chloroisothiazolinone;
the propellant is one or a mixture of more of carbon dioxide, nitrogen, isobutane, isopentane, propane and butane, trichloromonofluoromethane, difluoromethane, trichlorotetrafluoroethane and nitrous oxide;
the plant essential oil is one or more of tea tree essential oil, oleum Lavandula Angustifolia, oleum Rosae Rugosae, flos Pruni mume essential oil, notoginseng radix essential oil, and herba Menthae essential oil.
9. A preparation method of a plant oxidation-resistant daily chemical product is characterized by comprising the following steps:
1) Weighing the raw materials according to the plant antioxidant daily chemical product of claim 7 or 8;
2) Heating fatty acid to completely melt, adding pH regulator and water, stirring, adding Notoginseng radix-containing plant antioxidant composition and cosolvent, mixing, adding skin caring agent, oil, skin cleaning agent, viscosity regulator, antiseptic, essence or plant essential oil, pressing liquid propellant, and mixing to obtain plant antioxidant cleansing foam, cleansing gel or cleansing milk;
or mixing Notoginseng radix-containing plant antioxidant composition, skin caring agent, oil and cosolvent, heating, stirring, adding water, stopping heating, stirring, adding pH regulator, viscosity regulator, antiseptic, essence or plant essential oil, pressing liquid propellant, and mixing to obtain plant antioxidant essence, essence spray or essence water;
or, stirring the viscosity regulator and water, adding the pH regulator, mixing until the mixture is clear and transparent, adding the osmotic pressure regulator, and mixing uniformly to obtain a stable solution for later use; mixing and dissolving a plant antioxidant composition containing pseudo-ginseng, a skin care agent, grease and a cosolvent, adding the mixture into a stable solution, stirring, adding a preservative, essence or plant essential oil, and uniformly mixing to obtain a plant antioxidant mask paste or mask liquid;
or mixing oil and oily skin care agent, heating, stirring for dissolving, mixing plant antioxidant composition containing Notoginseng radix, water-based skin care agent, cosolvent, viscosity regulator and water for dissolving, adding into oil and oily skin care agent, heating, stirring, adding antiseptic, essence or plant essential oil, stopping heating, stirring and cooling to obtain plant antioxidant skin care emulsion.
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