CN108354868A - A kind of preparation and application of plant whitening and antioxidant composition and its chemical product - Google Patents
A kind of preparation and application of plant whitening and antioxidant composition and its chemical product Download PDFInfo
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- CN108354868A CN108354868A CN201810396995.6A CN201810396995A CN108354868A CN 108354868 A CN108354868 A CN 108354868A CN 201810396995 A CN201810396995 A CN 201810396995A CN 108354868 A CN108354868 A CN 108354868A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The present invention relates to the preparation and application of a kind of plant whitening and antioxidant composition and its chemical product.The plant whitening and antioxidant composition includes the component of following parts by weight：0.5 30 parts of baikal skullcap root decoction pieces, 0.1 40 parts of mulberry leaf medicine materical crude slice, 0.5 30 parts of flos mume medicine materical crude slice, 0.1 40 parts of licorice piece, 0.5 30 parts of kuh-seng medicine materical crude slice.Composition of the present invention, raw material sources natural plants, it is mild non-stimulated, it is safe and efficient, it is had shown that through research, this plant composition has inhibiting effect to L tyrosinases, there is elimination effect to oxygen radical, can be made into whitening skin lightening, anti-aging, reduces wrinkle generation, improve the daily chemical products of skin function, including dosage forms such as facial mask, essence lotion, skin care emulsifiable paste, skin-care gel, mildy wash, bath oils, for cleaning and maintaining for each position of whole body.
Description
Technical field
The present invention relates to daily chemical products fields, and in particular to a kind of plant whitening and antioxidant composition and its chemical product
Preparation and application.
Background technology
With the development and improvement of living standard of society, demand of the people to whitening skin is increasingly enhanced.Human body complexion
The depth depend primarily on content and the distribution of melanin.Melanin is mainly formed by the melanocyte of basal layer of epidermis, then
It is transferred in basal cell, as migrating for epidermal cell is brought to epidermis holostrome, the last depigmentation with falling off for keratinocyte,
The structure function and quantity of melanocyte directly affect the content of melanin in skin.In skin metabolism cyclic process, exist
Tyrosine in melanocyte tissue is made in tyrosinase, dopachrome interconvertible enzyme, sour (DHICA) oxidizing ferment of dihydroxy indole
Gradually it is changed into eumelanin or pheomelanin through intermediates such as DOPA, DOPA quinone, dopachrome, dihydroxy indoles with lower.Ultraviolet light
The factors such as irradiation, environmental pollution, endocrine disorder, heredity can cause melanocyte metabolic disorder, melanocyte to be secreted black
Pigment increase makes local skin blackening, generates pigmentation et al. body pigmentation after freckle, chloasma, senile plaque and inflammation
Disease.
Traditional whitening active ingredients hydrogen peroxide, mercury and mercuric compounds and phenol derivatives, can reach quick whitening
The effect of, but it is with adverse reactions such as cytotoxicity, irritation, sensitizations, oneself is banned in cosmetics at present.Mesh
Before, skin-whitening agents are typically using tyrosinase as action target spot, by inhibiting tyrosinase activity or tyrosine being blocked to give birth to
Achieve the effect that skin whitening at the oxidative pathway of melanin to reduce the generation of melanin.It lists in kind, to junket ammonia
The research of sour enzyme inhibitor is more, such as quinhydrones, ursin, VC and its derivative, kojic acid, but with the hair of cosmetic industry
There is the substance (such as quinhydrones) compared with strong cytotoxicity seldom to have used for exhibition, and VC is unstable oxidizable, and kojic acid is to skin irritatin
Property is stronger.Therefore, finding natural, the safe and efficient plant whitening active constituent of a new generation becomes domestic and international technology heat in recent years
One of point.
On the other hand, the expression that tyrosinase is promoted due to ultraviolet induction generation oxygen radical, makes melanin shape
At increasing, and key enzyme and rate-limiting enzyme of the tyrosinase as organism B16 cell, it is a kind of cupric oxidoreducing enzyme,
During it is catalyzed B16 cell, the presence of oxygen is requirement.Therefore, the substance with antioxidation can pass through
It reduces oxygen radical and blocks or weaken the activity of tyrosinase, reduce the synthesis of melanin, the colour of skin is contributed to improve.Meanwhile
It is anti-oxidant to reduce various extrinsic factors, such as the free radical of ultraviolet radiation, smog generation, to avoid the glue of skin
Fibrinogen oxidation (yellow is presented) causes the colour of skin partially yellow.
It is proved according to experimental study, radix scutellariae has antiviral, antibacterial, anti-oxidant, elimination free radical, antiallergy, patron saint
Through various pharmacological actions such as member；Flos mume has scavenging activated oxygen, anti-platelet aggregation, prevents melanin deposition, is anti-
Depression and other effects；Radix Glycyrrhizae has anti-inflammatory, whitening and antioxidation；Mulberry leaf have hypoglycemic, anti-oxidant, anti-inflammatory, antitumor etc.
Effect；Kuh-seng has anti-oxidant, antiallergy, anti-inflammatory, analgesia and other effects.Therefore, the plant whitening that is prepared by mentioned component and anti-
Oxidising composition and its chemical product have high value of practical and broader market prospects.
Invention content
The purpose of the present invention is intended to provide a kind of preparation and application of plant whitening and antioxidant composition and its chemical product.
To achieve the goals above, the present invention provides following technical scheme：
A kind of plant whitening and antioxidant composition and its chemical product of the present invention, which is characterized in that the plant
Object whitening and antioxidant composition include the component of following parts by weight：It is 0.5-30 parts of baikal skullcap root decoction pieces, 0.1-40 parts of mulberry leaf medicine materical crude slice, white
0.5-30 parts of plum blossom medicine materical crude slice, 0.1-40 parts of licorice piece, 0.5-30 parts of kuh-seng medicine materical crude slice.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the extraction of the composition
Method is：
Radix scutellariae, mulberry leaf and flos mume medicine materical crude slice, co-grinding is taken to add m respectively:V is returned than the 30-98% ethyl alcohol measured for 3-20 times
Stream carries 1-3 times, 15-180 minutes each, and extracting solution merges, filtering, filtrate concentration, spare.
Extracting liquorice medicine materical crude slice, coarse powder add m:V ratios are 3-20 times and measure methanol eddy extraction 1-3 times, flow back every time 15-180 points
Clock, extracting solution merge, filtering, filtrate concentration, spare.
Kuh-seng medicine materical crude slice, coarse powder is taken to add m:V ratios are 3-20 times and measure methanol eddy extraction 1-3 times, flow back every time 15-180 points
Clock, extracting solution merge, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 20-98% ethanol elutions are crossed, eluent merges, and drying is
.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the composition is used for day
Parts by weight in change product are 0.001-20 parts.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that made of the composition
Chemical product is facial mask, essence lotion, skin care milk, skin-care gel, mildy wash, bath oil, preferably facial mask, essence lotion, skin care milk.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the face containing the composition
The preparation method of film is：
Method one：The plant whitening and antioxidant composition, 0.001-1 parts of borneol of 0.001-1 parts of parts by weight are taken respectively,
1-30 parts of propylene glycol, 1-30 parts of diethylene glycol monoethyl ether, 0.01-5 parts of azone, 0.01-20 parts of poly- sorb is added
After mixing, 0.01-20 parts of tremella polysaccharides, 0.01-20 parts of polysaccharides, 0.01-20 parts of Poria cocos is added in alcohol ester -80
Polysaccharide, 0.01-2 parts of xanthans, 0.01-2 parts of preservative, 0.01-2 parts of essence and suitable quantity of water is thoroughly mixed
It is even, packing to get.
Method two：Take the plant whitening and antioxidant composition of 0.01-2 parts of parts by weight, be added 1-30 parts propylene glycol,
After mixing, 0.01-5 parts of Sodium Hyaluronate, 0.01-5 parts of water solubility is added in 0.01-20 parts of Polyoxyethylene Sorbitan Monooleate
Ceramide, 0.01-2 parts of carbomer, 0.01-2 parts of preservative, 0.01-2 parts of essence, 0.0001-0.1 parts of pearly-lustre
Powder and suitable quantity of water, be thoroughly mixed uniformly, it is filling to get.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the essence containing the composition
The preparation method of Hua Shui is：
Method one：The plant whitening and antioxidant composition, 0.001-1 parts of ice of 0.001-20 parts of parts by weight are taken respectively
1-30 parts of propylene glycol, 0.01-20 parts of Polyoxyethylene Sorbitan Monooleate is added after mixing in piece, and 0.01-20 parts of mulberry fruit is added
Extract, 0.01-20 parts of Herba Dendrobii extract, 0.01-5 parts of preservative, 0.01-2 parts of essence and suitable quantity of water, is sufficiently stirred
Be uniformly mixed, packing to get.
Method two：Take the plant whitening and antioxidant composition of 0.01-1 parts of parts by weight, be added 1-30 parts propylene glycol,
0.01-1 parts of shea butter, 1-20 parts of glycerine, 0.01-5 parts of polyglyceryl fatty acid ester, 0.01-20 parts of polysorbate
After mixing, 0.001-1 parts of glutamic acid, 0.001- is added in ester -80,0.01-5 parts of Labraso
1 part of glycine, 0.001-1 parts of cysteine, 0.01-20 parts of Cremophor RH40,0.01-5 parts of preservative,
0.01-2 parts of essence and suitable quantity of water, be thoroughly mixed uniformly, low-temperature mixed nitrogen, it is filling to get.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the shield containing the composition
The preparation method of skin breast is：
Method one：It takes 0.05-5 parts of Carbopol of parts by weight, 0.05-5 parts of glycerine to be uniformly mixed respectively, is added
0.1-10 parts of triethanolamine adjusts pH value to neutrality, and 0.001-0.5 parts of plant whitening and antioxidant composition, 1-10 is added
Part propylene glycol, 0.1-10 parts of Polyoxyethylene Sorbitan Monooleate after mixing, add 0.01-5 parts of shea butter, 0.1-10
Part polyglyceryl fatty acid ester, 0.1-10 parts of Labraso, 0.01-5 parts of preservative, 0.01-3 parts
Essence and suitable quantity of water, emulsifying 1-30 minutes, it is filling to get.
Method two：The olive oil, 0.1-5 parts of isomery hexadecane, 0.1-8 parts of C12- of 0.05-2 parts of parts by weight are taken respectively
15 alcohol benzoic ethers, 0.1-8 parts of isobutyl palmitate, 0.1-5 parts of hexadecanol, 0.1-5 parts of octadecyl alcolol, 0.1-10 parts
Shea butter, heating are uniformly mixed, be added 0.5-10 part of plant whitening and the propylene glycol of antioxidant composition and 1-30 parts,
0.5-20 parts of diethylene glycol monoethyl ether, 0.1-20 parts of polysorbate mixed liquor, heating are uniformly mixed, then add 0.1-5 parts
Wolfberry fruit extract, 0.1-5 parts of Notogineng Extract, 0.01-1 parts of Sodium Hyaluronate, 0.5-10 parts of glycerine, 0.1-10 parts
Oleic acid LABRAFIL M 1944CS, 0.1-10 parts of polyethylene glycol acid glyceride, 0.01-5 parts of preservative, 0.01-2 parts of perfume (or spice)
Essence and suitable quantity of water keep 60-100 DEG C of emulsifying 5-60 minute, cool down, it is filling to get.
A kind of described plant whitening and antioxidant composition and its chemical product, which is characterized in that the plant composition day
Change product have inhibiting effect to l-tyrosine enzyme, have elimination effect to oxygen radical, have whitening skin lightening, anti-aging, reduce wrinkle
The effect of line generates, conditioning skin function, suitable for cleaning and maintaining for each position of whole body.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, it should be noted that following embodiment
It is only used to illustrate and not limit the technical solutions of the present invention, although being described the invention in detail with reference to following embodiments,
However, those skilled in the art should understand that, it is still possible to modify or equivalently replace the present invention, without departing from the present invention
Spirit and scope any modification or partial replacement, should all cover in scope of the presently claimed invention.
The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same
Or production firm person is not specified in instrument, is the conventional products that can be obtained by commercially available purchase.
Embodiment 1：
A kind of facial mask liquid of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 0.5 part of radix scutellariae, 10 parts of mulberry leaf and 30 parts of flos mume medicine materical crude slice, co-grinding add to take parts by weight respectively
30% alcohol reflux carries 3 times, and every time plus 3 times of amount solvents, reflux 180 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 20 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 10 times are measured solvents, reflux
100 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 30 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 1 time, and every time plus 20 times are measured solvents, reflux
15 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 30% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
The plant whitening and antioxidant composition, 0.001 part of borneol of 0.001 part of parts by weight are taken respectively, and the third of 5 parts is added
Glycol, 0.1 part of diethylene glycol monoethyl ether, 0.5 part of azone, 2 parts of Polyoxyethylene Sorbitan Monooleate after mixing, are added 20
Part tremella polysaccharides, 20 parts of polysaccharides, 20 parts of pachymaran, 0.02 part of xanthans, 0.1 part of preservative, 0.06
Part essence and suitable quantity of water, be thoroughly mixed uniformly, packing to get.
Embodiment 2：
A kind of jelly facial mask of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 30 parts of radix scutellariae, 0.1 part of mulberry leaf and 10 parts of flos mume medicine materical crude slice, co-grinding add to take parts by weight respectively
60% alcohol reflux carries 2 times, and every time plus 10 times of amount solvents, reflux 100 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 40 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 1 time, and every time plus 20 times are measured solvents, reflux
15 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 0.5 part of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 3 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 50% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
The plant whitening and antioxidant composition of 2 parts of parts by weight are taken, 10 parts of propylene glycol, 5 parts of polysorbate-is added
80 after mixing, be added 5 parts Sodium Hyaluronate, 0.01 part of water-soluble ceramide, 0.1 part of carbomer, 0.6 part
Preservative, 0.1 part of essence, 0.01 part of pearl powder and suitable quantity of water, be thoroughly mixed uniformly, it is filling to get.
Embodiment 3：
A kind of essence lotion of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 10 parts of radix scutellariae, 40 parts of mulberry leaf and 0.5 part of flos mume medicine materical crude slice, co-grinding add to take parts by weight respectively
98% alcohol reflux carries 1 time, and every time plus 20 times of amount solvents, reflux 15 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 0.1 part of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 3 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 15 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 10 times are measured solvents, reflux
100 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 70% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
It takes the plant whitening and antioxidant composition, 0.6 part of borneol of 20 parts of parts by weight respectively, the third the two of 30 parts is added
Alcohol, 10 parts of Polyoxyethylene Sorbitan Monooleate after mixing, be added 0.01 part of Fructus Mori extract, 0.01 part of Herba Dendrobii extract,
0.1 part of preservative, 0.6 part of essence and suitable quantity of water, be thoroughly mixed uniformly, packing to get.
Embodiment 4：
A kind of essence spraying of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 15 parts of radix scutellariae, 20 parts of mulberry leaf and 15 parts of flos mume medicine materical crude slice, co-grinding add 50% to take parts by weight respectively
Alcohol reflux carries 2 times, and every time plus 10 times of amount solvents, reflux 120 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 20 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 10 times are measured solvents, reflux
100 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 15 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 6 times are measured solvents, reflux
80 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 98% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
Take the plant whitening and antioxidant composition of 0.4 part of parts by weight, be added 10 parts of propylene glycol, 1 part of shea butter,
10 parts of glycerine, 1 part of polyglyceryl fatty acid ester, 2 parts of Polyoxyethylene Sorbitan Monooleate, 1.5 parts of caprylic capric polyethylene glycol glycerol
Ester after mixing, be added 1 part of glutamic acid, 1 part of glycine, 1 part of cysteine, 3 parts of Cremophor RH40,
0.2 part of preservative, 0.5 part of essence and suitable quantity of water, be thoroughly mixed uniformly, low-temperature mixed nitrogen, it is filling to get.
Embodiment 5：
A kind of skin-care milk curd of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 5 parts of radix scutellariae, 5 parts of mulberry leaf and 10 parts of flos mume medicine materical crude slice, co-grinding add 80% second to take parts by weight respectively
Alcohol reflux carries 3 times, and every time plus 8 times of amount solvents, reflux 60 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 10 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 5 times are measured solvents, reflux
120 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 20 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 1 time, and every time plus 15 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 80% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
It takes 0.8 part of Carbopol of parts by weight, 5 parts of glycerine to be uniformly mixed respectively, 1.5 parts of triethanolamine tune is added
PH value is saved to neutrality, 0.5 part of plant whitening and antioxidant composition, 5 parts of propylene glycol, 0.5 part of polysorbate-is added
80 after mixing, adds the poly- second of 5 parts of shea butter, 0.8 part of polyglyceryl fatty acid ester, 1.2 parts of caprylic capric two
Alcohol glyceride, 0.8 part of preservative, 1 part of essence and suitable quantity of water, emulsifying 15 minutes, it is filling to get.
Embodiment 6：
A kind of skin care emulsifiable paste of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 1 part of radix scutellariae, 0.5 part of mulberry leaf and 1 part of flos mume medicine materical crude slice, co-grinding add 70% to take parts by weight respectively
Alcohol reflux carries 3 times, and every time plus 20 times of amount solvents, reflux 180 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 5 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 8 times are measured solvents, reflux 90
Minute, extracting solution merges, filtering, filtrate concentration, spare.
It is 10 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 10 times are measured solvents, reflux
60 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 60% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
Take respectively the olive oil of 1 part of parts by weight, 0.5 part of isomery hexadecane, 2 parts of C12-15 alcohol benzoic ethers, 2 parts
Isobutyl palmitate, 1.5 parts of hexadecanol, 1.5 parts of octadecyl alcolol, 10 parts of shea butter, heating are uniformly mixed, and are added 2 parts
Plant whitening and antioxidant composition and 15 parts of propylene glycol, 5 parts of diethylene glycol monoethyl ether, 5 parts of polysorbate it is mixed
Liquid is closed, heating is uniformly mixed, then adds 5 parts of wolfberry fruit extract, 5 parts of Notogineng Extract, 1 part of Sodium Hyaluronate, 4 parts sweet
Oil, 7 parts oleic acid LABRAFIL M 1944CS, 5 parts of polyethylene glycol acid glyceride, 0.6 part of preservative, 0.1 part of essence and
Suitable quantity of water keeps 75 DEG C of emulsifyings 60 minutes, cooling, it is filling to get.
Embodiment 7：
A kind of facial mask liquid of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 15 parts of radix scutellariae, 20 parts of mulberry leaf and 15 parts of flos mume medicine materical crude slice, co-grinding add 50% to take parts by weight respectively
Alcohol reflux carries 2 times, and every time plus 10 times of amount solvents, reflux 120 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 20 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 10 times are measured solvents, reflux
100 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 15 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 6 times are measured solvents, reflux
80 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 98% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
Take the plant whitening and antioxidant composition, 1 part of borneol of 1 part of parts by weight respectively, be added 20 parts propylene glycol,
After mixing, 0.01 part of silver is added in 0.1 part of diethylene glycol monoethyl ether, 5 parts of azone, 5 parts of Polyoxyethylene Sorbitan Monooleate
Fungus polysaccharides, 0.01 part of polysaccharides, 0.01 part of pachymaran, 1 part of xanthans, 0.01 part of preservative, 0.1 part of perfume (or spice)
Essence and suitable quantity of water, be thoroughly mixed uniformly, packing to get.
Embodiment 8：
A kind of Wash-free mask of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 5 parts of radix scutellariae, 5 parts of mulberry leaf and 10 parts of flos mume medicine materical crude slice, co-grinding add 80% second to take parts by weight respectively
Alcohol reflux carries 3 times, and every time plus 8 times of amount solvents, reflux 60 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 10 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 5 times are measured solvents, reflux
120 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 20 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 1 time, and every time plus 15 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 80% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
The plant whitening and antioxidant composition of 0.01 part of parts by weight are taken, 5 parts of propylene glycol, 0.5 part of poly- sorb is added
Alcohol ester -80 after mixing, be added 0.01 part Sodium Hyaluronate, 5 parts of water-soluble ceramide, 1 part of carbomer, 1 part
Preservative, 0.05 part of essence, 0.001 part of pearl powder and suitable quantity of water, be thoroughly mixed uniformly, it is filling to get.
Embodiment 9：
A kind of surfactant of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
It is that 1 part of radix scutellariae, 0.5 part of mulberry leaf and 1 part of flos mume medicine materical crude slice, co-grinding add 70% to take parts by weight respectively
Alcohol reflux carries 3 times, and every time plus 20 times of amount solvents, reflux 180 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 5 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 8 times are measured solvents, reflux 90
Minute, extracting solution merges, filtering, filtrate concentration, spare.
It is 10 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 10 times are measured solvents, reflux
60 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 60% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
It takes the plant whitening and antioxidant composition, 0.01 part of borneol of 5 parts of parts by weight respectively, the third the two of 10 parts is added
After mixing, 20 parts of Fructus Mori extract, 20 parts of Herba Dendrobii extract, 1 part anti-is added in alcohol, 1 part of Polyoxyethylene Sorbitan Monooleate
Rotten agent, 0.1 part of essence and suitable quantity of water, be thoroughly mixed uniformly, packing to get.
Embodiment 10：
A kind of Essence of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 10 parts of radix scutellariae, 40 parts of mulberry leaf and 0.5 part of flos mume medicine materical crude slice, co-grinding add to take parts by weight respectively
98% alcohol reflux carries 1 time, and every time plus 20 times of amount solvents, reflux 15 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 0.1 part of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 3 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 15 parts of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 2 times, and every time plus 10 times are measured solvents, reflux
100 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 70% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
The plant whitening and antioxidant composition of 10 parts of parts by weight are taken, the wooden fruit of 30 parts of propylene glycol, 0.01 part of breast is added
Oil, 5 parts of glycerine, 1 part of polyglyceryl fatty acid ester, 10 parts of Polyoxyethylene Sorbitan Monooleate, 3 parts of caprylic capric polyethylene glycol are sweet
Grease after mixing, be added 0.001 part of glutamic acid, 0.001 part of glycine, 0.001 part of cysteine, 1 part
Cremophor RH40,0.5 part of preservative, 0.1 part of essence and suitable quantity of water are thoroughly mixed uniformly, low-temperature mixed
Nitrogen, it is filling to get.
Embodiment 11：
A kind of face cream of plant whitening and antioxidant composition, the preparation method of the chemical product are as follows：
1, it extracts：
It is that 30 parts of radix scutellariae, 0.1 part of mulberry leaf and 10 parts of flos mume medicine materical crude slice, co-grinding add to take parts by weight respectively
60% alcohol reflux carries 2 times, and every time plus 10 times of amount solvents, reflux 100 minutes, extracting solution merge, filtering, and filtrate concentration is spare.
It is 40 parts of licorice piece to take parts by weight, and coarse powder adds methanol eddy to extract 1 time, and every time plus 20 times are measured solvents, reflux
15 minutes, extracting solution merged, filtering, filtrate concentration, spare.
It is 0.5 part of kuh-seng medicine materical crude slice to take parts by weight, and coarse powder adds methanol eddy to extract 3 times, and every time plus 3 times are measured solvents, reflux
180 minutes, extracting solution merged, filtering, filtrate concentration, spare.
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 50% ethanol elution are crossed, eluent merges, is drying to obtain.
2, it prepares：
Take respectively the olive oil of 2 parts of parts by weight, 5 parts of isomery hexadecane, 0.1 part of C12-15 alcohol benzoic ethers, 0.1 part
Isobutyl palmitate, 2 parts of hexadecanol, 0.5 part of octadecyl alcolol, 0.1 part of shea butter, heating be uniformly mixed, be added 6 parts
Plant whitening and antioxidant composition and 20 parts of propylene glycol, 10 parts of diethylene glycol monoethyl ether, 10 parts of polysorbate
Mixed liquor, heating are uniformly mixed, then add 0.1 part of wolfberry fruit extract, 0.1 part of Notogineng Extract, 0.1 part of hyaluronic acid
Sodium, 4 parts of glycerine, 5 parts of oleic acid LABRAFIL M 1944CS, 10 parts of polyethylene glycol acid glyceride, 0.05 part of preservative,
0.5 part of essence and suitable quantity of water keeps 75 DEG C of emulsifyings 60 minutes, cooling, it is filling to get.
Embodiment 12：
A kind of inhibition of l-tyrosine enzyme and the DPPH radicals scavengings experiment of plant whitening and antioxidant composition：
1, experimental method：
1.1L- tyrosinase Inhibition tests
This experiment is carried out using absorption photometry.100 μ L sample solution are added in 96 orifice plates, 50 μ L junket ammonia are added per hole
Sour enzyme solutions room temperature is protected from light 10 minutes, is eventually adding 50 μ L l-tyrosine solution.If 3 multiple holes, 2, each sample is dilute
Gradient is released, carries out 10 times of doubling dilutions (if sample has apparent tyrosinase inhibitory action, 4, each sample after primary dcreening operation
Dilution gradient carries out 2 times of doubling dilutions and carries out secondary screening).Negative control replaces sample, blank control to replace junket ammonia with PBS with PBS
Sour enzyme, remaining operation all same.Reaction solution is mixed well, 37 DEG C are protected from light incubation 30 minutes.492nm extinction light is read with microplate reader
Angle value, Δ OD values are lower, show that sample is stronger to the inhibition of tyrosinase.Calculate tyrosinase inhibition rate and IC50。
1.2DPPH radicals scavengings are tested
Sample is added in 96 orifice plates using absorption photometry progress in this experiment, if 3 multiple holes, 2 dilutions of each sample
Gradient carries out 10 times of doubling dilutions (if sample has apparent DPPH free radicals effect clearly, 4, each sample dilute after primary dcreening operation
Gradient is released, 2 times of doubling dilutions is carried out and carries out secondary screening), per 100 μ L of hole, 0.1M DPPH100 μ L are added per hole.Negative control is used
50% ethyl alcohol replaces sample, blank control to replace DPPH with 50% ethyl alcohol, remaining operation all same.Mix well reaction solution, room
Temperature is protected from light incubation 30 minutes.517nm absorption photometric values are read with microplate reader, Δ OD values are lower, show sample to the clear of free radical
Except activity is higher.Calculate DPPH free radical scavenging activities and IC50。
2, experiment material：
Kojic acid (Sigma, article No.：K3125-5G, lot number：K3125), Trolox (Sigma, article No.：238813-1G, batch
Number：BCBP2767V), DPPH (Sigma, article No.：D9132-1G, lot number：STBF5255V), l-tyrosine (Sigma, article No.：
V900426-100G, lot number：BB0881V), tyrosinase (Sigma, article No.：T3824-50KU, lot number：SLBJ5647V), phosphorus
Acid dihydride sodium (Xilong Chemical Co., Ltd, lot number：1202011), disodium hydrogen phosphate (Xilong Chemical Co., Ltd,
Lot number：111021), absolute ethyl alcohol (Li Anlongboization (Tianjin) Pharmaceuticals Ltd article No.：D4540-100ML, lot number：
20150205), DMSO (in end reaction system, the volume fraction of DMSO<1%), Multiskan GO microplate reader (Thermo),
(the upper macro experimental facilities of Nereid has for PRACTUM224-1CN electronic balances (Satorius), GNP-9270 water isolation types constant incubator
Limit company), 30~300 μ L volley of rifle fires (Thermo companies), each range liquid-transfering gun (big dragon company).
3, experimental result：
Table 1：Tyrosinase inhibits and anti-DPPH pharmacodynamic results table
The results show that 1%DMSO (Vehicle controls) has no significant effect pilot system；The IC50 of kojic acid (positive control) is
39.93μg/mL；The IC50 of Trolox (positive control) is 6.11 μ g/mL；Tool is used alone in radix scutellariae, mulberry leaf, flos mume, Radix Glycyrrhizae
There is anti-DPPH free radicals effect；Mulberry leaf, Radix Glycyrrhizae, kuh-seng exclusive use have effects that l-tyrosine enzyme inhibits；5 taste medicinal materials are mixed
It is refined to form the enzyme inhibition of composition l-tyrosine and anti-DPPH Free Radicals obviously increase.
Claims (8)
1. a kind of plant whitening and antioxidant composition and its chemical product, which is characterized in that the plant whitening and anti-oxidant
Composition includes the component of following parts by weight：0.5-30 parts of baikal skullcap root decoction pieces, 0.1-40 parts of mulberry leaf medicine materical crude slice, flos mume medicine materical crude slice 0.5-30
Part, 0.1-40 parts of licorice piece, 0.5-30 parts of kuh-seng medicine materical crude slice.
2. a kind of plant whitening according to claim 1 and antioxidant composition and its chemical product, which is characterized in that the group
Close object extracting method be：
Radix scutellariae, mulberry leaf and flos mume medicine materical crude slice, co-grinding is taken to add m respectively:V for the 30-98% alcohol refluxs that 3-20 times is measured than carrying
1-3 times, 15-180 minutes each, extracting solution merges, filtering, filtrate concentration, spare；
Extracting liquorice medicine materical crude slice, coarse powder add m:V ratios are 3-20 times and measure methanol eddy extraction 1-3 times, and reflux 15-180 minutes, carry every time
Liquid is taken to merge, filtering, filtrate concentration are spare；
Kuh-seng medicine materical crude slice, coarse powder is taken to add m:V ratios are 3-20 times and measure methanol eddy extraction 1-3 times, and reflux 15-180 minutes, carry every time
Liquid is taken to merge, filtering, filtrate concentration are spare；
Above-mentioned three kinds of concentrates are mixed, macroporous resin column, 20-98% ethanol elutions are crossed, eluent merges, is drying to obtain.
3. a kind of plant whitening and antioxidant composition according to claim 1-2 and its chemical product, which is characterized in that should
The parts by weight that composition is used in chemical product are 0.001-20 parts.
4. a kind of plant whitening and antioxidant composition according to claim 1-3 and its chemical product, which is characterized in that should
Chemical product made of composition is facial mask, essence lotion, skin care milk, skin-care gel, mildy wash, bath oil, preferably facial mask, essence
Water, skin care milk.
5. a kind of plant whitening and antioxidant composition according to claim 1-4 and its chemical product, which is characterized in that contain
The preparation method of the facial mask of the composition is：
Method one：The plant whitening and antioxidant composition, 0.001-1 parts of borneol of 0.001-1 parts of parts by weight are taken respectively, are added
1-30 parts of propylene glycol, 1-30 parts of diethylene glycol monoethyl ether, 0.01-5 parts of azone, 0.01-20 parts of polysorbate-
80 after mixing, be added 0.01-20 parts of tremella polysaccharides, 0.01-20 parts of polysaccharides, 0.01-20 parts of pachymaran,
0.01-2 parts of xanthans, 0.01-2 parts of preservative, 0.01-2 parts of essence and suitable quantity of water is thoroughly mixed uniformly, point
Dress to get；
Method two：The plant whitening and antioxidant composition of 0.01-2 parts of parts by weight are taken, 1-30 parts of propylene glycol, 0.01- is added
After mixing, 0.01-5 parts of Sodium Hyaluronate, 0.01-5 parts of water-soluble nerve acyl is added in 20 parts of Polyoxyethylene Sorbitan Monooleate
Amine, 0.01-2 parts of carbomer, 0.01-2 parts of preservative, 0.01-2 parts of essence, 0.0001-0.1 parts of pearl powder and suitable
Measure water, be thoroughly mixed uniformly, it is filling to get.
6. a kind of plant whitening and antioxidant composition according to claim 1-4 and its chemical product, which is characterized in that contain
The preparation method of the essence lotion of the composition is：
Method one：The plant whitening and antioxidant composition, 0.001-1 parts of borneol for taking 0.001-20 parts of parts by weight respectively, add
Enter 1-30 parts of propylene glycol, 0.01-20 parts of Polyoxyethylene Sorbitan Monooleate after mixing, 0.01-20 parts of mulberry fruit extraction is added
Object, 0.01-20 parts of Herba Dendrobii extract, 0.01-5 parts of preservative, 0.01-2 parts of essence and suitable quantity of water, is thoroughly mixed
Uniformly, dispense to get；
Method two：The plant whitening and antioxidant composition of 0.01-1 parts of parts by weight are taken, 1-30 parts of propylene glycol, 0.01-1 is added
Part shea butter, 1-20 parts of glycerine, 0.01-5 parts of polyglyceryl fatty acid ester, 0.01-20 parts of Polyoxyethylene Sorbitan Monooleate,
0.01-5 parts of Labraso after mixing, be added 0.001-1 parts glutamic acid, 0.001-1 parts
Glycine, 0.001-1 parts of cysteine, 0.01-20 parts of Cremophor RH40,0.01-5 parts of preservative, 0.01-
2 parts of essence and suitable quantity of water, be thoroughly mixed uniformly, low-temperature mixed nitrogen, it is filling to get.
7. a kind of plant whitening and antioxidant composition according to claim 1-4 and its chemical product, which is characterized in that contain
The preparation method of the skin care milk of the composition is：
Method one：It takes 0.05-5 parts of Carbopol of parts by weight, 0.05-5 parts of glycerine to be uniformly mixed respectively, 0.1-10 is added
The triethanolamine of part adjusts pH value to neutrality, and 0.001-0.5 parts of plant whitening and the third of antioxidant composition, 1-10 parts is added
Glycol, 0.1-10 parts of Polyoxyethylene Sorbitan Monooleate after mixing, add 0.01-5 parts shea butter, 0.1-10 parts poly-
Fatty acid glyceride, 0.1-10 parts of Labraso, 0.01-5 parts of preservative, 0.01-3 parts of essence
And suitable quantity of water, emulsifying 1-30 minutes, it is filling to get；
Method two：The olive oil of 0.05-2 parts of parts by weight, 0.1-5 parts of isomery hexadecane, 0.1-8 parts of C12-15 alcohol are taken respectively
Benzoic ether, 0.1-8 parts of isobutyl palmitate, 0.1-5 parts of hexadecanol, 0.1-5 parts of octadecyl alcolol, 0.1-10 parts of breast wood
Fruit oil, heating are uniformly mixed, the plant whitening and antioxidant composition and 1-30 parts of propylene glycol, 0.5-20 of 0.5-10 parts of addition
The diethylene glycol monoethyl ether of part, 0.1-20 parts of polysorbate mixed liquor, heating are uniformly mixed, then add 0.1-5 parts of matrimony vine
Extract, 0.1-5 parts of Notogineng Extract, 0.01-1 parts of Sodium Hyaluronate, 0.5-10 parts of glycerine, 0.1-10 parts of oleic acid
LABRAFIL M 1944CS, 0.1-10 parts of polyethylene glycol acid glyceride, 0.01-5 parts of preservative, 0.01-2 parts of essence and suitable
Measure water, keep 60-100 DEG C of emulsifying 5-60 minute, cool down, it is filling to get.
8. a kind of plant whitening and antioxidant composition according to claim 1-7 and its chemical product, which is characterized in that should
Plant composition chemical product has inhibiting effect to l-tyrosine enzyme, has elimination effect to oxygen radical, has whitening skin lightening, delays
Aging reduces the effect of wrinkle generates, improves skin function, suitable for cleaning and maintaining for each position of whole body.
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| CN111904911A (en) * | 2020-08-25 | 2020-11-10 | 云南省药物研究所 | Panax notoginseng-containing plant antioxidant composition and application thereof |
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