CN111888305A - Preparation and application of acne-removing and skin-beautifying composition - Google Patents
Preparation and application of acne-removing and skin-beautifying composition Download PDFInfo
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- CN111888305A CN111888305A CN202010989286.6A CN202010989286A CN111888305A CN 111888305 A CN111888305 A CN 111888305A CN 202010989286 A CN202010989286 A CN 202010989286A CN 111888305 A CN111888305 A CN 111888305A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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Abstract
The invention belongs to the technical field of cosmetics production, and particularly relates to preparation and application of a composition for removing acne and beautifying skin. The acne-removing and skin-beautifying composition mainly comprises the following raw materials in percentage by weight: FC-1750 (acne removing active agent) 0.5-5.0%, JYZ-1 (acne removing restorer, INCI name: fructus Rosae Laevigatae (Rosa LAEVIGATA) extract) 0.1-5.0%; 0.1-5.0% of pomelo (Citrus GRANDIS) fruit extract, 0.1-6.0% of folium Artemisiae Argyi (ARTEMISIA ARGYI) extract, and 0.5-5.0% of ABT-2600 amino acid whitening agent. The acne-removing and skin-beautifying composition provided by the invention can obviously control oil, namely inhibit excessive sebum secretion, and also can inhibit or kill propionibacterium acnes, has an obvious effect on especially seriously blocking pores, oxidizing the openings to be black, namely blackheads, and also has a good repairing effect on skin lesions such as pockmarks, pigmentation and the like.
Description
Technical Field
The invention belongs to the technical field of cosmetics production, and particularly relates to preparation and application of a composition for removing acne and beautifying skin.
Background
Acne is a chronic inflammatory skin problem of the pilosebaceous unit, and the occurrence of acne is mainly closely related to factors such as hyperseborrhea, blockage of pilosebaceous ducts, bacterial infection and inflammatory reaction. After adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced. Meanwhile, abnormal keratinization of the pilosebaceous canal causes blockage of the canal, obstruction of sebum discharge and formation of a keratotic plug, namely, comedo. A number of microorganisms in the hair follicle, particularly propionibacterium acnes, multiply in number, and lipases produced by propionibacterium acnes break down sebum to produce free fatty acids, while chemotactic inflammatory cells and mediators, ultimately inducing and exacerbating the inflammatory response. It is manifested as acne (white or black), papule, pustule, and nodule, and severe cases form scar, which is chronic in course and easy to repeat.
Due to the improvement of living standard, such as the improvement of meat consumption, and the attention of people on beauty, the incidence rate of acne has obvious growth trend. Acne is a skin disease with a very high incidence rate, which is better at puberty, and according to a research in the United states, the incidence rate of acne in people of 12-24 years is 85 percent. Acne lesions contain a large number of propionibacterium acnes, which can produce enzymes that break down sebum, thereby causing alterations in the sebum composition. Such as triglycerides in sebum, can be broken down to produce glycerol and free fatty acids. Recent studies have shown that sebaceous gland cells themselves can also produce small amounts of free fatty acids. The generation of free fatty acid is increased in skin lesions of acne patients, so that excessive sebum overflow can be caused, the hair follicle mouth is abnormally keratinized, sebum is accumulated to form acne, the number of propionibacterium acnes secondary to hair follicles is increased sharply, sebaceous gland ducts are ruptured, inflammatory acne is caused, white comedo and black comedo appear, and great mental trouble is caused to patients.
At present, products for treating acne which are adopted on the market mainly comprise corticosteroids, chemical antibiotics, hormone antagonists, astringents, chemical bactericides, anti-inflammatory agents and the like, although inflammation can be eliminated in a short time, because pathogenic factors of acne cannot be fundamentally solved, secretion of sebaceous glands cannot be inhibited, hair follicle blockage cannot be fundamentally eliminated, symptoms and root causes are treated, acne usually recurs, and the phenomenon of repeated confusion occurs. In addition, pathogenic bacteria easily generate drug resistance to chemical bactericides, and the recurrent acne is more difficult to treat, forms intractable acne, and can be accompanied with uneven pox marks and pigmentation, thereby generating new and unaesthetic phenomena for the skin.
Disclosure of Invention
The invention aims to overcome the defects of the existing acne removing product and provides a preparation method of a composition which is safer, has the effects of removing acne and beautifying skin and an application of the composition in cosmetics.
The acne-removing and skin-beautifying composition of the invention is realized by the following steps:
FC-1750 (acne removing active agent) 0.5-5.0%, JYZ-1 (acne removing restorer, INCI name: fructus Rosae Laevigatae (ROSA LAEVIGATA) extract) 0.1-5.0%, fructus Citri Grandis (Citrus GRANDIS) fruit extract 0.1-5.0%, folium Artemisiae Argyi (ARTEMISIA ARGYI) extract 0.1-6.0%, and ABT-2600 amino acid whitening agent 0.5-5.0%.
Preferably, the acne-removing and skin-beautifying composition is composed of the following raw materials in percentage by weight: FC-1750 of 0.3-3.0%, JYZ-1 of 1.5-3.0%. 0.3-3.0% of pomelo (Citrus GRANDIS) fruit extract, 0.1-6.0% of folium artemisiae argyi (ARTEMISIAARGYI) extract and 1.0-3.0% of ABT-2600 amino acid whitening agent.
In conclusion, the acne-removing and skin-beautifying composition provided by the invention can obviously control oil, namely inhibit excessive sebum secretion, and also inhibit or kill propionibacterium acnes, has an obvious effect on especially serious pore blockage, and the opening is oxidized into black, namely blackheads, and also has a good repairing effect on skin lesions such as pockmarks, acne marks, pigmentation and the like.
Detailed Description
The invention will be better understood from the following illustrative, but non-limiting examples. As will be apparent to those skilled in the art, they are all considered to be included within the scope of the present invention.
[ example 1 (essence), and example 2 (emulsion) ]
The information of manufacturers, goods numbers and the like of part of raw materials in the composition disclosed by the embodiment of the invention is as follows:
| the raw materials of the invention | Supplier factory | Code for goods |
| Folium Artemisiae Argyi extract | Beijing institute of biochemical technology for determining tolerance | NQ-2016 |
| Acne removing active agent | Beijing institute of biochemical technology for determining tolerance | FC-1750 |
| Acne removing repairing agent | Beijing institute of biochemical technology for determining tolerance | JYZ-1 |
| Amino acid whitening agent | Beijing institute of biochemical technology for determining tolerance | ABT-2600 |
1. The diameter measurement result of each group of inhibition zone
The Propionibacterium acnes not only can decompose triglyceride in sebum, but also can generate a large amount of free fatty acid to stimulate hair follicles and peripheral tissues to generate inflammation, and can also induce monocytes and keratinocytes to secrete cell factors to cause or aggravate acne inflammation, so that the Propionibacterium acnes can repair skin lesions in a manner of inhibiting or killing the Propionibacterium acnes.
1) And preparing a culture medium: respectively weighing 33g of lecithin-Tween nutrient agar culture medium and 29.3g of liquid thioglycollate culture medium, adding 1L of ultrapure water, stirring, heating, boiling to dissolve completely, subpackaging, sterilizing at 120 deg.C under high pressure for 30min, cooling to 60 deg.C-70 deg.C, and keeping warm in a water bath for use. 2) Recovery of propionibacterium acnes and preparation of bacterial suspension: taking propionibacterium acnes freeze-dried powder, fusing an ampoule bottle under an alcohol lamp, adding 1mL of 0.85% physiological saline, uniformly stirring, inoculating onto 3 plates containing a culture medium, and culturing for 3-4 days under anaerobic conditions at 37 ℃. The slant colonies were scraped with an inoculating loop, and the suspension was diluted appropriately with physiological saline to a concentration of 106-. Taking the bacterial suspension under aseptic operation, and uniformly smearing the bacterial suspension on a culture medium by using a coating rod. Then, the Oxford cup is lightly placed on the surface of the solidified culture medium by using sterile forceps, and the Oxford cup (the outer diameter is 8mm) is lightly pressed to ensure good contact. Adding 200 mu L of test solution into an Oxford cup, culturing for 48h in an incubator at 37 ℃, taking out, and measuring the diameter of the effective bacteriostatic zone of the test substance in each culture dish. A matrix control group and a positive control group of 0.1% triclosan (DP300) are also provided. Each set of experiments was repeated twice, and samples were taken twice each time for testing. Antibacterial effect judgment standard: the high sensitivity is that the diameter of the bacteriostatic zone is more than 20 mm; the diameter of the inhibition zone is 10-20mm, and the drug is moderate-sensitivity; the diameter of the inhibition zone is less than 10mm, and the drug resistance is achieved.
The bacteriostatic effect of each group on propionibacterium acnes is shown in table 1
| Group of | Zone of inhibitionDiameter/mm (X + -S, n ═ 4) |
| Matrix control group | 8.2±0.1 |
| EXAMPLE 1 group | 27.8±0.2 |
| EXAMPLE 2 group | 33.6±0.1 |
| 0.1% DP300 Positive control | 32.5±1.0 |
As can be seen from Table 1, the diameter of the inhibition zone of the blank control matrix group is about 8mm, and the diameter of the inhibition zone of the positive control group added with 0.1% DP300 is 32.5mm, which indicates that the matrix control group has no interference to the inhibition test result, the groups of examples 1 and 2 have better inhibition effect on Propionibacterium acnes, and the inhibition effect of example 2 is stronger than that of example 1.
2. Results of measurement of sebum secretion, pore size and skin moisture content using two groups of examples 1 and 2
Two groups of 30 volunteers each had acne lesions.
The sponge for measuring oil content is used for lightly pressing the T-shaped area (forehead and periphery of nose) and the U-shaped area (cheek on two sides) of the face for 6s to absorb oil, and after the test of a skin analyzer, data are recorded. Detection of pore size: shooting with a digital microscope to observe 5cm inside the window2The area is the test area, and the size and number of pores visible is recorded, each time the same site is detected. Measurement of skin moisture content: and measuring the moisture data of the skin of the target part of the volunteer by using a moisture sensor, inputting the data into a computer system, and analyzing. And aligning a probe of the skin analyzer to the skin of the target position for measurement and recording data.
Changes in skin repair after 4 weeks using example 1 group Table 2
| Skin properties | Number of examples | Before use | After use |
| Sebum amount in T-shaped zone | 30 | 88.6±9.6 | 45.7±8.3 |
| Sebum amount in U-shaped area | 30 | 38.9±15.6 | 8.6±9.2 |
| Size of skin pores | 30 | 20.3±5.6 | 18.2±6.5 |
| Moisture of skin | 30 | 39.5±13.7 | 42.1±10.3 |
Skin repair changes after 4 weeks using example 2 group table 3
| Skin properties | Number of examples | Before use | After use |
| Sebum amount in T-shaped zone | 30 | 88.6±9.6 | 41.1±4.2 |
| Sebum amount in U-shaped area | 30 | 38.9±15.6 | 7.3±3.2 |
| Size of skin pores | 30 | 20.3±5.6 | 17.3±2.6 |
| Moisture of skin | 30 | 39.5±13.7 | 44.1±9.1 |
After 4 weeks, the sebum amount of the T-shaped area, the sebum amount of the U-shaped area and the size of skin pores are obviously reduced, the skin moisture is improved, certain moisturizing performance is achieved, and the emulsion in the example 2 has a better effect than the aqueous solution in the example 1.
2. Skin damage was repaired after 4 weeks using example 1 and example 2 groups
Two groups of 50 volunteers each had acne lesions.
Comparative efficacy of two groups of acne volunteers in 4 weeks table 4
Both of the use examples 1 and 2 had excellent acne removing effect, and the effect of repairing skin lesions was superior to that of the example 1 group after 4 weeks in the example 2 group. The acne-removing skin-beautifying product is worthy of popularization and application in the field of cosmetics.
Claims (3)
1. The acne-removing skin-beautifying composition is characterized by comprising the following raw materials in percentage by weight: FC-1750 (acne removing active agent) 0.5-5.0%; JYZ-1 (acne restorer, INCI name: fructus Rosae Laevigatae (ROSA LAEVIGATA)) 0.1-5.0%; 0.1-5.0% of fructus Citri Grandis (Citrus GRANDIS) extract; 0.1-6.0% of folium Artemisiae Argyi (ARTEMISIA ARGYI) extract; 0.5-5.0% of ABT-2600 amino acid whitening agent.
2. The composition for removing acne and beautifying skin as claimed in claim 1, wherein said composition for removing acne and beautifying skin is composed of the following raw materials by weight percent: FC-1750 is 0.3-3.0%; JYZ-1 (acne restorer, INCI name: fructus Rosae Laevigatae (ROSA LAEVIGATA) extract) 1.5-3.0%; 0.3-3.0% of extract of fruit of Citrus GRANDIS (Citrus GRANDIS); 0.1-6.0% of folium Artemisiae Argyi (ARTEMISIA ARGYI) extract; ABT-2600 amino acid whitening agent 1.0-3.0%.
3. The preparation and application of the acne-removing skin-care composition according to claims 1-2, characterized in that the acne-removing skin-care composition is added into a matrix such as aqua, gel, essence, emulsion, cream and the like at the temperature of below 90 ℃ according to the addition amount of 0.1-5.0% by mass, and is mixed and stirred homogeneously to obtain the cosmetic which can remarkably control oil, inhibit excessive sebum secretion, inhibit or kill propionibacterium acnes, particularly has serious pore blockage and remarkable blackness due to oxidation at the opening, has good efficacy on blackhead, can treat skin damage such as pockmarks, acne marks, pigmentation and the like, has good repairing efficacy, and is moisture-retaining and non-irritating and can satisfactorily care the skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010989286.6A CN111888305A (en) | 2020-09-19 | 2020-09-19 | Preparation and application of acne-removing and skin-beautifying composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010989286.6A CN111888305A (en) | 2020-09-19 | 2020-09-19 | Preparation and application of acne-removing and skin-beautifying composition |
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| Publication Number | Publication Date |
|---|---|
| CN111888305A true CN111888305A (en) | 2020-11-06 |
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| CN202010989286.6A Pending CN111888305A (en) | 2020-09-19 | 2020-09-19 | Preparation and application of acne-removing and skin-beautifying composition |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100531503B1 (en) * | 2003-07-02 | 2005-11-28 | 나드리화장품주식회사 | Cosmetics compositions comprising natural materials |
| CN107519081A (en) * | 2017-08-25 | 2017-12-29 | 杭州惠博士健康产业有限公司 | A kind of composition and preparation method that effect is repaired with anti-acne |
| CN108324648A (en) * | 2018-04-17 | 2018-07-27 | 佛山市汇汾化妆品科技有限公司 | A kind of composition of anti-acne |
-
2020
- 2020-09-19 CN CN202010989286.6A patent/CN111888305A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100531503B1 (en) * | 2003-07-02 | 2005-11-28 | 나드리화장품주식회사 | Cosmetics compositions comprising natural materials |
| CN107519081A (en) * | 2017-08-25 | 2017-12-29 | 杭州惠博士健康产业有限公司 | A kind of composition and preparation method that effect is repaired with anti-acne |
| CN108324648A (en) * | 2018-04-17 | 2018-07-27 | 佛山市汇汾化妆品科技有限公司 | A kind of composition of anti-acne |
Non-Patent Citations (4)
| Title |
|---|
| 刘澄等: "JYZ-1型烟气浊度在线监测仪介绍", 《电力环境保护》 * |
| 李克顺: "DRZ-1导热硅脂和JYZ-1绝缘硅脂研制成功", 《精细与专用化学品》 * |
| 李静贞等: "国产JYZ-1型YAG激光机治疗眼前节疾病疗效分析", 《中国医学科学院学报》 * |
| 郑平: "JYZ-1型内燃机车加油自动控制装置", 《内燃机车》 * |
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