CN111868060A - 二氢吡啶并酞嗪酮衍生物、其制备方法及应用 - Google Patents

二氢吡啶并酞嗪酮衍生物、其制备方法及应用 Download PDF

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CN111868060A
CN111868060A CN201980018770.XA CN201980018770A CN111868060A CN 111868060 A CN111868060 A CN 111868060A CN 201980018770 A CN201980018770 A CN 201980018770A CN 111868060 A CN111868060 A CN 111868060A
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dihydro
fluoro
pyrido
fluorophenyl
phthalazin
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CN111868060B (zh
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罗会兵
周华勇
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Shanghai Allist Medicine Polytron Technologies Inc
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Abstract

本发明涉及下述通式(I)所示的二氢吡啶并酞嗪酮衍生物、其制备方法与应用，式中R1、R2、R3、m、n、环A和环B如说明书中所定义。本发明所述二氢吡啶并酞嗪酮衍生物具有良好的PARP抑制活性，可用于治疗或预防因抑制PARP活性而改善的疾病。
Figure DDA0002677539050000011

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN201980018770.XA 2018-03-14 2019-03-14 二氢吡啶并酞嗪酮衍生物、其制备方法及应用 Active CN111868060B (zh)

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WO2022222964A1 (zh) * 2021-04-23 2022-10-27 成都百裕制药股份有限公司 吡啶衍生物及其在医药上的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042040A1 (en) * 1999-01-11 2000-07-20 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
CN102171214A (zh) * 2008-08-06 2011-08-31 生物马林药物股份有限公司 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma
US20130053365A1 (en) * 2011-08-30 2013-02-28 Biomarin Pharmaceutical, Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000042040A1 (en) * 1999-01-11 2000-07-20 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
CN102171214A (zh) * 2008-08-06 2011-08-31 生物马林药物股份有限公司 聚(adp-核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
WO2013028495A1 (en) * 2011-08-19 2013-02-28 Biomarin Pharmaceutical Inc. Dihydropyridophthalazinone inhibitors of poly (adp-ribose) polymerase (parp) for the treatment of multiple myeloma
US20130053365A1 (en) * 2011-08-30 2013-02-28 Biomarin Pharmaceutical, Inc. Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨玉宏: ""1.选择性PARP1/2抑制剂的设计合成与活性研究2.噻吩并香豆素类化合物合成的方法学研究"", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 *

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