CN111840657A - Coating preparation for gastroscope detection tube - Google Patents
Coating preparation for gastroscope detection tube Download PDFInfo
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- CN111840657A CN111840657A CN202010848768.XA CN202010848768A CN111840657A CN 111840657 A CN111840657 A CN 111840657A CN 202010848768 A CN202010848768 A CN 202010848768A CN 111840657 A CN111840657 A CN 111840657A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
Abstract
The invention discloses a coating preparation for a gastroscope detection tube, which comprises the following raw materials in parts by weight: 15-20 parts of organic solvent, 5-8 parts of lubricant, 3-5 parts of polycarbonate, 10-15 parts of polytetrafluoroethylene, 10-14 parts of polyvinyl alcohol, 3-5 parts of polylactic acid, 4-6 parts of bacteriostatic agent, 2-4 parts of carbamate and 7-10 parts of epoxy chloropropane; increased the surface smoothness degree of gastroscope pipe through adding emollient, can be better entering esophagus and stomach when using, make the gastroscope can play the growth of inhibitory bacteria through adding bacteriostatic agent, prevent that the bacterium from breeding too much effect, through adding anticorrosive, the hydrophobizing agent, antistatic agent and antioxidant, can make the surface of gastroscope pipe possess anticorrosive hydrophobic and anti-oxidant and antistatic characteristic, the safety in utilization of gastroscope has been increased, and through adding anesthesia auxiliary agent and the auxiliary agent that relieves pain, and then make the gastroscope alleviate the pain of patient's esophagus and stomach and play local anesthesia's effect in use, thereby improve the efficiency that the gastroscope detected.
Description
Technical Field
The invention relates to the technical field of medical material coating preparations, in particular to a coating preparation for a gastroscope detection tube.
Background
Gastroscopes are well known as a method of medical examination and also as an instrument used in such examinations. It is inserted into the stomach by means of a thin and flexible tube, and the doctor can directly observe the pathological changes of esophagus, stomach and duodenum, especially for tiny pathological changes. The gastroscopy can directly observe the real condition of the detected part, and can further carry out pathological biopsy and cytology detection on the suspicious lesion part to further clearly diagnose, thereby being the preferred detection method for the upper digestive tract lesion.
The invention is disclosed in China: CN110051885A discloses a gastric tube material for digestive system department and a preparation method thereof, the preparation method of the gastric tube material for digestive system department provided by the invention has the advantages of simple operation, easily obtained raw materials, low preparation cost, low requirements on equipment and reaction conditions, suitability for large-scale production, higher market popularization and application values and strong clinical practicability, overcomes the defects of poor biocompatibility, insufficient elasticity or unstable performance, easy decomposition to generate toxic and harmful substances, damage to the body health of a patient, poor surface lubricity, easy occurrence of nasal mucosa congestion, edema and even bleeding in the process of intubation and tube drawing, strong rejection reaction of the inserted patient, and pain brought to the patient in both physiology and mind, and has good biocompatibility, the elasticity is good, the performance is stable, the anti-infection and antibacterial effects are obvious, the surface lubricity is good, and the mechanical property is excellent;
however, the effects achieved by the existing stomach tube material or coating preparation thereof during preparation or blending are often single, the corrosion resistance is poor, the surface smoothness is low, and the effects of local anesthesia and pain relief are not achieved, so that the problems of stimulation and damage to internal organs of patients and the like are easily caused in the using process, and the using risk is high.
Disclosure of Invention
Technical problem to be solved
In response to the deficiencies of the prior art, the present invention provides a coating formulation for a gastroscopic detection tube.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: 15-20 parts of organic solvent, 5-8 parts of lubricant, 3-5 parts of polycarbonate, 10-15 parts of polytetrafluoroethylene, 10-14 parts of polyvinyl alcohol, 3-5 parts of polylactic acid, 4-6 parts of bacteriostatic agent, 2-4 parts of carbamate, 7-10 parts of epoxy chloropropane, 2-5 parts of analgesic assistant, 5-7 parts of defoaming agent, 2-4 parts of hydrophobic agent, 3-5 parts of anesthetic assistant, 5-15 parts of antioxidant, 5-10 parts of antistatic agent, 5-10 parts of preservative, 4-9 parts of flame retardant, 6-10 parts of light stabilizer and 7-9 parts of heat stabilizer;
the antistatic agent is any one of 3-15 parts of quaternary ammonium salt, 10-15 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate, 10-13 parts of tristearin and 13-16 parts of dihydroimidazole;
the organic solvent is any one of 1-5 parts of ethyl acetate, 2-5 parts of tetrahydrofuran, 25-40 parts of water, 10-15 parts of dimethylformamide and 15-18 parts of dimethyl sulfoxide;
the flame retardant is any one of 4-10 parts of tetrabromobisphenol A, 2-5 parts of brominated polystyrene, 2-6 parts of decabromodiphenylethane, 1-4 parts of brominated epoxy resin and 10-15 parts of tetrabromobisphenol A;
the light stabilizer is selected from any one of 2-10 parts of dihydroxy benzophenone, 2-8 parts of tetrahydroxy benzophenone, 3-10 parts of trihydroxy benzophenone and 4-8 parts of benzotriazole.
Preferably, the lubricant comprises the following raw materials, by mass, 5-8 parts of polyacrylamide, 5-8 parts of procaine, 2-4 parts of acrylamide and 2-4 parts of glyceryl stearate.
Preferably, the analgesic auxiliary agent is any one of 3-5 parts of oxymorphone and 10-13 parts of thalidomide.
Preferably, the defoaming agent comprises the following raw materials in parts by mass: 6-10 parts of fluorosilicone, 5-8 parts of cyclic polydimethylsiloxane and 10-15 parts of emulsifier.
Preferably, the hydrophobic agent comprises the following raw materials in parts by mass: 10-20 parts of polysilazane, 6-10 parts of organic silicon resin, 8-13 parts of chlorinated polyethylene, 5-8 parts of polysilazane resin, 3-6 parts of acrylate and 10-13 parts of thickening agent.
Preferably, the anesthetic aid comprises the following raw materials in parts by mass: 2-6 parts of lidocaine and 25-45 parts of water.
Preferably, the bacteriostatic agent comprises the following raw materials in parts by mass: 2-5 parts of acetanilide, 3-6 parts of thiazole, 2-6 parts of quaternary ammonium salt, 5-10 parts of carboxymethyl chitosan, 3-7 parts of domiphen bromide and 3-5 parts of glycerol.
Preferably, the anesthetic aid is any one of 2-6 parts of lidocaine, 1-3 parts of tetracaine, 4-8 parts of lidocaine carbonate, 1-4 parts of ropivacaine and 1-4 parts of lidocaine carbonate.
Preferably, the preservative comprises the following raw materials in parts by mass: 5-10 parts of methylisothiazolinone, 3-10 parts of ethylene glycol dimethyl ether, 4-11 parts of dimethylol dimethyl hydantoin, 6-12 parts of dimethyl hydantoin and 5-10 parts of water.
Preferably, the heat stabilizer comprises the following raw materials in parts by mass: 5-9 parts of glyceride, 3-10 parts of ultraviolet absorbent, 4-8 parts of dihydropyridine, 6-12 parts of methyl tin mercaptide and 5-10 parts of water.
(III) advantageous effects
Compared with the prior art, the invention provides a coating preparation for a gastroscope detection tube, which has the following beneficial effects:
firstly, the surface smoothness of the gastroscope catheter is improved by adding the lubricant, the gastroscope catheter can better enter the esophagus and the stomach when in use, and the gastroscope can play the roles of inhibiting the growth of bacteria and preventing the excessive breeding of the bacteria by adding the bacteriostatic agent.
And secondly, the surface of the gastroscope catheter has the characteristics of corrosion resistance, hydrophobicity, oxidation resistance and static resistance by adding the preservative, the hydrophobic agent, the antistatic agent and the antioxidant, so that the use safety of the gastroscope is improved.
And by adding the anesthesia auxiliary agent and the pain relieving auxiliary agent, the pain of the esophagus and the stomach of a patient is relieved and the local anesthesia effect is achieved when the gastroscope is used, so that the detection efficiency of the gastroscope is improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to data in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
The invention provides a technical scheme that: a coating preparation for a gastroscope detection tube comprises the following raw materials in parts by weight: 15 parts of organic solvent, 5 parts of lubricant, 3 parts of polycarbonate, 10 parts of polytetrafluoroethylene, 10 parts of polyvinyl alcohol, 3 parts of polylactic acid, 4 parts of bacteriostatic agent, 2 parts of carbamate, 7 parts of epoxy chloropropane, 2 parts of pain relieving auxiliary agent, 5 parts of defoaming agent, 2 parts of hydrophobic agent, 3 parts of anesthetic auxiliary agent, 5 parts of antioxidant, 5 parts of antistatic agent, 5 parts of preservative, 4 parts of flame retardant, 6 parts of light stabilizer and 9 parts of heat stabilizer;
the antistatic agent is any one of 3 parts of quaternary ammonium salt, 10 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate, 10 parts of glyceryl tristearate and 13 parts of dihydroimidazole, and 13 parts of dihydroimidazole is preferred;
the organic solvent is selected from any one of 1 part of ethyl acetate, 2 parts of tetrahydrofuran, 10 parts of dimethylformamide and 15 parts of dimethyl sulfoxide, and preferably: 2 parts of tetrahydrofuran;
the flame retardant is selected from any one of 4 parts of tetrabromobisphenol A, 2 parts of brominated polystyrene, 2 parts of decabromodiphenylethane, 1 part of brominated epoxy resin and 10 parts of tetrabromobisphenol A, preferably: 2 parts of decabromodiphenylethane;
the light stabilizer is selected from any one of 2 parts of dihydroxy benzophenone, 2 parts of tetrahydroxy benzophenone, 3 parts of trihydroxy benzophenone and 4 parts of benzotriazole, and the light stabilizer is preferably: 4 parts of benzotriazole.
In this embodiment, specifically: the lubricant comprises the following raw materials of, by mass, 5 parts of polyacrylamide, 5 parts of procaine, 2 parts of acrylamide and 2 parts of glyceryl stearate; the coating has a lubricating effect by blending the raw material formula, and is beneficial to the movement of the catheter in a human body during the gastroscopy.
In this embodiment, specifically: the analgesic auxiliary agent is any one of 3 parts of oxymorphone and 10 parts of thalidomide; the addition of oxymorphone or thalidomide to the coating provides local anesthesia to the coated formulation after coating on a gastroscope catheter.
In this embodiment, specifically: the defoaming agent comprises the following raw materials in parts by mass: 6 parts of fluorosilicone, 5 parts of cyclic polydimethylsiloxane, 22 parts of water and 10 parts of emulsifier; the raw material formula can be added into the defoaming agent during preparation, so that the preparation does not generate bubbles, and the stability of the preparation is improved.
In this embodiment, specifically: the hydrophobic agent comprises the following raw materials in parts by mass: 10 parts of polysilazane, 6 parts of organic silicon resin, 8 parts of chlorinated polyethylene, 5 parts of polysilazane resin, 3 parts of acrylate and 10 parts of thickening agent; the coating can be made hydrophobic by adding the raw material formula.
In this embodiment, specifically: the anesthetic aid comprises the following raw materials in parts by mass: 2 parts of lidocaine and 25 parts of water; the licarbaduo is easily dissolved in water, and the coating has an anesthetic effect by blending the aqueous solution, so that the discomfort of a patient during gastroscope detection is relieved.
In this embodiment, specifically: the bacteriostatic agent comprises the following raw materials in parts by mass: 2 parts of acetanilide, 3 parts of thiazole, 2 parts of quaternary ammonium salt, 5 parts of carboxymethyl chitosan, 3 parts of domiphen bromide and 3 parts of glycerol; the coating has antibacterial property by the raw material proportion, can effectively inhibit the breeding of bacteria or fungi, increases the safety of the gastroscope, and avoids the infection of bacteria or fungi of a patient after the gastroscope is used.
In this embodiment, specifically: the anesthetic auxiliary agent is selected from any one of 2 parts of lidocaine, 1 part of tetracaine, 4 parts of lidocaine carbonate, 1 part of ropivacaine and 1 part of lidocaine carbonate, and preferably: 2 parts of lidocaine; the anesthetic aid can be selected from any one of the above raw materials, and provides various selectivity.
In this embodiment, specifically: the preservative comprises the following raw materials in parts by mass: 5 parts of methylisothiazolinone, 3 parts of ethylene glycol dimethyl ether, 4 parts of dimethylol dimethyl hydantoin, 6 parts of dimethyl hydantoin and 5 parts of water; the preservative can prevent the main body part and the plasticized part of the gastroscope from being rotten.
In this embodiment, specifically: the heat stabilizer comprises the following raw materials in parts by mass: 5 parts of glyceride, 3 parts of ultraviolet absorber, 4 parts of dihydropyridine, 6 parts of methyl tin mercaptide and 5 parts of water.
Example two
The invention provides a technical scheme that: a coating preparation for a gastroscope detection tube comprises the following raw materials in parts by weight: 20 parts of organic solvent, 8 parts of lubricant, 5 parts of polycarbonate, 15 parts of polytetrafluoroethylene, 14 parts of polyvinyl alcohol, 5 parts of polylactic acid, 6 parts of bacteriostatic agent, 4 parts of carbamate, 10 parts of epoxy chloropropane, 5 parts of pain relieving auxiliary agent, 7 parts of defoaming agent, 4 parts of hydrophobic agent, 5 parts of anesthetic auxiliary agent, 15 parts of antioxidant, 10 parts of antistatic agent, 10 parts of preservative, 9 parts of flame retardant, 10 parts of light stabilizer and 9 parts of heat stabilizer;
the antistatic agent is selected from any one of 15 parts of quaternary ammonium salt, 15 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate, 13 parts of tristearin and 16 parts of dihydroimidazole, and the antistatic agent is preferably selected from the following components: 15 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate;
the organic solvent is selected from any one of 5 parts of ethyl acetate, 5 parts of tetrahydrofuran, 15 parts of dimethylformamide and 18 parts of dimethyl sulfoxide, and preferably: 5 parts of ethyl acetate;
the flame retardant is selected from any one of 10 parts of tetrabromobisphenol A, 5 parts of brominated polystyrene, 6 parts of decabromodiphenylethane, 4 parts of brominated epoxy resin and 15 parts of tetrabromobisphenol A, preferably: 15 parts of tetrabromobisphenol A;
the light stabilizer is selected from any one of 10 parts of dihydroxy benzophenone, 8 parts of tetrahydroxy benzophenone, 10 parts of trihydroxy benzophenone and 8 parts of benzotriazole, and the light stabilizer is preferably: 10 parts of trihydroxybenzophenone.
In this embodiment, specifically: the lubricant comprises the following raw materials, by mass, 8 parts of polyacrylamide, 8 parts of procaine, 4 parts of acrylamide and 4 parts of glyceryl stearate; the coating has a lubricating effect by blending the raw material formula, and is beneficial to the movement of the catheter in a human body during the gastroscopy.
In this embodiment, specifically: the analgesic auxiliary agent is any one of 5 parts of oxymorphone and 13 parts of thalidomide; the addition of oxymorphone or thalidomide to the coating provides local anesthesia to the coated formulation after coating on a gastroscope catheter.
In this embodiment, specifically: the defoaming agent comprises the following raw materials in parts by mass: 10 parts of fluorosilicone, 8 parts of cyclic polydimethylsiloxane, 30 parts of water and 15 parts of emulsifier; the raw material formula can be added into the defoaming agent during preparation, so that the preparation does not generate bubbles, and the stability of the preparation is improved.
In this embodiment, specifically: the hydrophobic agent comprises the following raw materials in parts by mass: 20 parts of polysilazane, 10 parts of organic silicon resin, 13 parts of chlorinated polyethylene, 8 parts of polysilazane resin, 6 parts of acrylate and 13 parts of thickening agent; the coating can be made hydrophobic by adding the raw material formula.
In this embodiment, specifically: the anesthetic aid comprises the following raw materials in parts by mass: 6 parts of lidocaine and 45 parts of water; the licarbaduo is easily dissolved in water, and the coating has an anesthetic effect by blending the aqueous solution, so that the discomfort of a patient during gastroscope detection is relieved.
In this embodiment, specifically: the bacteriostatic agent comprises the following raw materials in parts by mass: 5 parts of acetanilide, 6 parts of thiazole, 6 parts of quaternary ammonium salt, 10 parts of carboxymethyl chitosan, 7 parts of domiphen bromide and 5 parts of glycerol; the coating has antibacterial property by the raw material proportion, can effectively inhibit the breeding of bacteria or fungi, increases the safety of the gastroscope, and avoids the infection of bacteria or fungi of a patient after the gastroscope is used.
In this embodiment, specifically: the anesthetic auxiliary agent is any one of 6 parts of lidocaine, 3 parts of tetracaine, 8 parts of lidocaine carbonate, 4 parts of ropivacaine and 4 parts of lidocaine carbonate, and the preferable formula is as follows: 4 parts of ropivacaine; the anesthetic aid can be selected from any one of the above raw materials, and provides various selectivity.
In this embodiment, specifically: the preservative comprises the following raw materials in parts by mass: 10 parts of methylisothiazolinone, 10 parts of ethylene glycol dimethyl ether, 11 parts of dimethylol dimethyl hydantoin, 12 parts of dimethyl hydantoin and 10 parts of water; the preservative can prevent the main body part and the plasticized part of the gastroscope from being rotten.
In this embodiment, specifically: the heat stabilizer comprises the following raw materials in parts by mass: 9 parts of glyceride, 10 parts of ultraviolet absorbent, 8 parts of dihydropyridine, 12 parts of methyl tin mercaptide and 10 parts of water,
EXAMPLE III
The invention provides a technical scheme that: a coating preparation for a gastroscope detection tube comprises the following raw materials in parts by weight: 16 parts of organic solvent, 6 parts of lubricant, 4 parts of polycarbonate, 11 parts of polytetrafluoroethylene, 11 parts of polyvinyl alcohol, 4 parts of polylactic acid, 5 parts of bacteriostatic agent, 3 parts of carbamate, 8 parts of epoxy chloropropane, 3 parts of pain relieving auxiliary agent, 6 parts of defoaming agent, 3 parts of hydrophobic agent, 4 parts of anesthetic auxiliary agent, 6 parts of antioxidant, 6 parts of antistatic agent, 6 parts of preservative, 5 parts of flame retardant, 7 parts of light stabilizer and 8 parts of heat stabilizer;
the antistatic agent is selected from any one of 4 parts of quaternary ammonium salt, 11 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate, 11 parts of tristearin and 14 parts of dihydroimidazole, and preferably: 11 parts of glyceryl tristearate;
the organic solvent is selected from any one of 4 parts of ethyl acetate, 4 parts of tetrahydrofuran, 13 parts of dimethylformamide and 17 parts of dimethyl sulfoxide, and preferably: 17 parts of dimethyl sulfoxide;
the flame retardant is selected from any one of 9 parts of tetrabromobisphenol A, 4 parts of brominated polystyrene, 5 parts of decabromodiphenylethane, 3 parts of brominated epoxy resin and 13 parts of tetrabromobisphenol A, preferably: 3 parts of brominated epoxy resin.
The light stabilizer is selected from any one of 6 parts of dihydroxy benzophenone, 7 parts of tetrahydroxy benzophenone, 7 parts of trihydroxy benzophenone and 6 parts of benzotriazole, and the light stabilizer is preferably: and 6 parts of benzotriazole.
In this embodiment, specifically: the lubricant comprises the following raw materials of, by mass, 7 parts of polyacrylamide, 7 parts of procaine, 3 parts of acrylamide and 3 parts of glyceryl stearate; the coating has a lubricating effect by blending the raw material formula, and is beneficial to the movement of the catheter in a human body during the gastroscopy.
In this embodiment, specifically: the analgesic auxiliary agent is any one of 4 parts of oxymorphone and 11 parts of thalidomide; the addition of oxymorphone or thalidomide to the coating provides local anesthesia to the coated formulation after coating on a gastroscope catheter.
In this embodiment, specifically: the defoaming agent comprises the following raw materials in parts by mass: 8 parts of fluorosilicone, 7 parts of cyclic polydimethylsiloxane, 24 parts of water and 13 parts of emulsifier; the raw material formula can be added into the defoaming agent during preparation, so that the preparation does not generate bubbles, and the stability of the preparation is improved.
In this embodiment, specifically: the hydrophobic agent comprises the following raw materials in parts by mass: 16 parts of polysilazane, 7 parts of organic silicon resin, 11 parts of chlorinated polyethylene, 7 parts of polysilazane resin, 5 parts of acrylate and 12 parts of thickening agent; the coating can be made hydrophobic by adding the raw material formula.
In this embodiment, specifically: the anesthetic aid comprises the following raw materials in parts by mass: 4 parts of lidocaine and 33 parts of water; the licarbaduo is easily dissolved in water, and the coating has an anesthetic effect by blending the aqueous solution, so that the discomfort of a patient during gastroscope detection is relieved.
In this embodiment, specifically: the bacteriostatic agent comprises the following raw materials in parts by mass: 4 parts of acetanilide, 4 parts of thiazole, 5 parts of quaternary ammonium salt, 7 parts of carboxymethyl chitosan, 6 parts of domiphen bromide and 4 parts of glycerol; the coating has antibacterial property by the raw material proportion, can effectively inhibit the breeding of bacteria or fungi, increases the safety of the gastroscope, and avoids the infection of bacteria or fungi of a patient after the gastroscope is used.
In this embodiment, specifically: the anesthetic auxiliary agent is any one of 6 parts of lidocaine, 2 parts of tetracaine, 6 parts of lidocaine carbonate, 3 parts of ropivacaine and 3 parts of lidocaine carbonate; the anesthetic aid can be selected from any one of the above raw materials, and is preferably: 3 parts of lidocaine carbonate, which provides various selectivity.
In this embodiment, specifically: the preservative comprises the following raw materials in parts by mass: 6 parts of methylisothiazolinone, 6 parts of ethylene glycol dimethyl ether, 7 parts of dimethylol dimethyl hydantoin, 11 parts of dimethyl hydantoin and 7 parts of water; the preservative can prevent the main body part and the plasticized part of the gastroscope from being rotten.
In this embodiment, specifically: the heat stabilizer comprises the following raw materials in parts by mass: 7 parts of glyceride, 8 parts of ultraviolet absorber, 6 parts of dihydropyridine, 7 parts of methyl tin mercaptide and 7 parts of water.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. A coating preparation for a gastroscope detection tube is characterized by comprising the following raw materials in parts by weight: 15-20 parts of organic solvent, 5-8 parts of lubricant, 3-5 parts of polycarbonate, 10-15 parts of polytetrafluoroethylene, 10-14 parts of polyvinyl alcohol, 3-5 parts of polylactic acid, 4-6 parts of bacteriostatic agent, 2-4 parts of carbamate, 7-10 parts of epoxy chloropropane, 2-5 parts of analgesic assistant, 5-7 parts of defoaming agent, 2-4 parts of hydrophobic agent, 3-5 parts of anesthetic assistant, 5-15 parts of antioxidant, 5-10 parts of antistatic agent, 5-10 parts of preservative, 4-9 parts of flame retardant, 6-10 parts of light stabilizer and 7-9 parts of heat stabilizer;
the antistatic agent is any one of 3-15 parts of quaternary ammonium salt, 10-15 parts of octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate, 10-13 parts of tristearin and 13-16 parts of dihydroimidazole;
the organic solvent is selected from any one of 1-5 parts of ethyl acetate, 2-5 parts of tetrahydrofuran, 10-15 parts of dimethylformamide and 15-18 parts of dimethyl sulfoxide;
the flame retardant is any one of 4-10 parts of tetrabromobisphenol A, 2-5 parts of brominated polystyrene, 2-6 parts of decabromodiphenylethane, 1-4 parts of brominated epoxy resin and 10-15 parts of tetrabromobisphenol A;
the light stabilizer is selected from any one of 2-10 parts of dihydroxy benzophenone, 2-8 parts of tetrahydroxy benzophenone, 3-10 parts of trihydroxy benzophenone and 4-8 parts of benzotriazole.
2. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the lubricant comprises the following raw materials, by mass, 5-8 parts of polyacrylamide, 5-8 parts of procaine, 2-4 parts of acrylamide and 2-4 parts of glyceryl stearate.
3. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the analgesic auxiliary agent is any one of 3-5 parts of oxymorphone and 10-13 parts of thalidomide.
4. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the defoaming agent comprises the following raw materials in parts by mass: 6-10 parts of fluorosilicone, 5-8 parts of cyclic polydimethylsiloxane, 22-30 parts of water and 10-15 parts of emulsifier.
5. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the hydrophobic agent comprises the following raw materials in parts by mass: 10-20 parts of polysilazane, 6-10 parts of organic silicon resin, 8-13 parts of chlorinated polyethylene, 5-8 parts of polysilazane resin, 3-6 parts of acrylate and 10-13 parts of thickening agent.
6. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the anesthetic aid comprises the following raw materials in parts by mass: 2-6 parts of lidocaine and 25-45 parts of water.
7. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the bacteriostatic agent comprises the following raw materials in parts by mass: 2-5 parts of acetanilide, 3-6 parts of thiazole, 2-6 parts of quaternary ammonium salt, 5-10 parts of carboxymethyl chitosan, 3-7 parts of domiphen bromide and 3-5 parts of glycerol.
8. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the anesthetic auxiliary agent is any one of 2-6 parts of lidocaine, 1-3 parts of tetracaine, 4-8 parts of lidocaine carbonate, 1-4 parts of ropivacaine and 1-4 parts of lidocaine carbonate.
9. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the preservative comprises the following raw materials in parts by mass: 5-10 parts of methylisothiazolinone, 3-10 parts of ethylene glycol dimethyl ether, 4-11 parts of dimethylol dimethyl hydantoin, 6-12 parts of dimethyl hydantoin and 5-10 parts of water.
10. The coating formulation for a gastroscopic detection tube according to claim 1 wherein: the heat stabilizer comprises the following raw materials in parts by mass: 5-9 parts of glyceride, 3-10 parts of ultraviolet absorbent, 4-8 parts of dihydropyridine, 6-12 parts of methyl tin mercaptide and 5-10 parts of water.
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| CN202010848768.XA CN111840657A (en) | 2020-08-21 | 2020-08-21 | Coating preparation for gastroscope detection tube |
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| CN202010848768.XA CN111840657A (en) | 2020-08-21 | 2020-08-21 | Coating preparation for gastroscope detection tube |
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