CN111757737A - 用于治疗三阴性乳腺癌的喹啉衍生物 - Google Patents
用于治疗三阴性乳腺癌的喹啉衍生物 Download PDFInfo
- Publication number
- CN111757737A CN111757737A CN201980016212.XA CN201980016212A CN111757737A CN 111757737 A CN111757737 A CN 111757737A CN 201980016212 A CN201980016212 A CN 201980016212A CN 111757737 A CN111757737 A CN 111757737A
- Authority
- CN
- China
- Prior art keywords
- acid
- breast cancer
- compound
- negative breast
- triple negative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供了一种用于治疗三阴性乳腺癌的喹啉衍生物,及其在制备用于肿瘤治疗的药物组合物的用途。具体而言,本发明涉及喹啉衍生物1‑[[[4‑(4‑氟‑2‑甲基‑1H‑吲哚‑5‑基)氧基‑6‑甲氧基喹啉‑7‑基]氧基]甲基]环丙胺在治疗三阴性乳腺癌中的用途,(I)。
Description
PCT国内申请,说明书已公开。
Claims (8)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2018102068312 | 2018-03-14 | ||
CN201810206831 | 2018-03-14 | ||
PCT/CN2019/077946 WO2019174590A1 (zh) | 2018-03-14 | 2019-03-13 | 用于治疗三阴性乳腺癌的喹啉衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111757737A true CN111757737A (zh) | 2020-10-09 |
CN111757737B CN111757737B (zh) | 2022-07-08 |
Family
ID=67908600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980016212.XA Active CN111757737B (zh) | 2018-03-14 | 2019-03-13 | 用于治疗三阴性乳腺癌的喹啉衍生物 |
Country Status (3)
Country | Link |
---|---|
US (1) | US11554115B2 (zh) |
CN (1) | CN111757737B (zh) |
WO (1) | WO2019174590A1 (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008112407A1 (en) * | 2007-03-14 | 2008-09-18 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
CN105311030A (zh) * | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 用于抗肿瘤的螺取代化合物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0814542A2 (pt) * | 2007-07-12 | 2014-09-30 | Tragara Pharmaceuticals Inc | Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores |
CN103664892B (zh) | 2010-08-01 | 2015-09-02 | 正大天晴药业集团股份有限公司 | 喹啉衍生物的结晶 |
EP3970694A1 (en) * | 2017-05-11 | 2022-03-23 | Vyluma Inc. | Atropine pharmaceutical compositions |
US20210255168A1 (en) * | 2018-06-13 | 2021-08-19 | King Faisal Specialist Hospital & Research Centre | A method of precision cancer therapy |
-
2019
- 2019-03-13 CN CN201980016212.XA patent/CN111757737B/zh active Active
- 2019-03-13 WO PCT/CN2019/077946 patent/WO2019174590A1/zh active Application Filing
- 2019-03-13 US US16/980,786 patent/US11554115B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008112407A1 (en) * | 2007-03-14 | 2008-09-18 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
CN105311030A (zh) * | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 用于抗肿瘤的螺取代化合物 |
Non-Patent Citations (1)
Title |
---|
于正洪: "《乳腺癌防治导读》", 30 November 2015, 东南大学出版社 * |
Also Published As
Publication number | Publication date |
---|---|
WO2019174590A1 (zh) | 2019-09-19 |
CN111757737B (zh) | 2022-07-08 |
US20200405709A1 (en) | 2020-12-31 |
US11554115B2 (en) | 2023-01-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN107001326B (zh) | 抗非小细胞肺癌的喹啉衍生物 | |
KR102490547B1 (ko) | 퀴놀린 유도체로 갑상선암을 치료하기 위한 방법과 용도 및 갑상선암을 치료하기 위한 약학적 조성물 | |
CN109069500B (zh) | 一种用于治疗胃癌的喹啉衍生物 | |
WO2016091165A1 (zh) | 治疗非小细胞肺癌的喹啉衍生物 | |
WO2017118401A1 (zh) | 喹啉衍生物用于治疗食管癌的用途及其治疗方法、药物组合物和试剂盒 | |
CN112584834B (zh) | 用于治疗结外nk/t细胞淋巴瘤的喹啉衍生物 | |
WO2020057536A1 (zh) | 用于治疗脑肿瘤的喹啉衍生物 | |
CN111757737B (zh) | 用于治疗三阴性乳腺癌的喹啉衍生物 | |
CN111757736B (zh) | 治疗鼻咽癌的喹啉衍生物 | |
CN106999485B (zh) | 抗肺鳞癌的喹啉衍生物 | |
CN112533600B (zh) | 用于治疗小细胞肺癌的喹啉衍生物 | |
CN117956999A (zh) | 杂芳基氧基萘类化合物的用途 | |
CN111110681A (zh) | 喹啉衍生物联合卡培他滨在治疗肝癌的用途 | |
CN112105361A (zh) | 用于治疗非小细胞肺癌的喹啉衍生物 | |
CN112294813A (zh) | 喹啉衍生物在治疗脊索瘤中的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |