CN111743621A - Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues - Google Patents

Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues Download PDF

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Publication number
CN111743621A
CN111743621A CN202010748466.5A CN202010748466A CN111743621A CN 111743621 A CN111743621 A CN 111743621A CN 202010748466 A CN202010748466 A CN 202010748466A CN 111743621 A CN111743621 A CN 111743621A
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CN
China
Prior art keywords
electrode
sheath
invasive
fixing ring
irreversible electroporation
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Pending
Application number
CN202010748466.5A
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Chinese (zh)
Inventor
姜涛
杨光
孙健勇
杨滨
王亚楠
夏彦民
王孝彬
陈家宽
杨珍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xi'an Chuangge Electric Technology Co ltd
Xian Jiaotong University
Air Force Medical University of PLA
Original Assignee
Xi'an Chuangge Electric Technology Co ltd
Xian Jiaotong University
Air Force Medical University of PLA
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Application filed by Xi'an Chuangge Electric Technology Co ltd, Xian Jiaotong University, Air Force Medical University of PLA filed Critical Xi'an Chuangge Electric Technology Co ltd
Priority to CN202010748466.5A priority Critical patent/CN111743621A/en
Publication of CN111743621A publication Critical patent/CN111743621A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00488—Esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The invention discloses an invasive electrode for irreversible electroporation therapy of esophageal tumor tissues, which comprises: the electrode comprises a fixed shell, a sheath, an electrode wire and an electrode; the fixed shell is provided with a traction mechanism, an electrode fixing ring is arranged in the accommodating cavity in a sliding manner, one end of the electrode fixing ring is connected with an electrode, the other end of the electrode fixing ring is abutted against one end of an elastic element, and the other end of the elastic element is abutted against the electrode sheath; the electrode wire penetrates through the sheath and the electrode sheath, one end of the electrode wire is connected with the traction mechanism, and the other end of the electrode wire is connected with the electrode or the electrode fixing ring. The invasive electrode for irreversible electroporation treatment of esophageal tumor tissues can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, is very suitable for the treatment of esophageal cancer, and greatly reduces the risk of operation of patients.

Description

Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues
Technical Field
The invention relates to an invasive electrode for irreversible electroporation therapy of esophageal tumor tissues
Background
Irreversible electroporation (IRE) ablation technology is to apply a high-voltage pulse electric field to tissue cells to make cell membranes generate perforation under the action of electric potential, and destroy the steady state of the cells, thereby leading the cells to die, and is mainly used for treating tumors. The IRE ablation treatment process mainly comprises the step of applying high-voltage pulse to tissues in a specific range through an electrode, so that the aim of inactivating tumor cells without influencing normal cells is fulfilled. The current electrodes are mainly classified into two types, needle electrodes and plate electrodes.
Needle-type electrodes such as NanoKnife NanoCustoms (Fritz S, SommerCM, Vollherbst D, et al. Irreversible electrophoresis of the pancreas isocyanate and safety in a tumor tissue fashion model Pancreas.2015,44(5):791 and 798), produced by Angio Dynamics, were inserted in parallel into the tumor tissue, and the size of the range of action was controlled by varying the spacing of the electrodes and the depth of insertion into the tumor tissue. The flat-plate electrode is used to place tumor tissue between two parallel electrodes, and only the tissue between the electrodes is ablated (Rombouts SJE, van Dijck WPM, Nijkamp MW, et al. clinical and clinical practice after iterative ablation of the surgery using two broad electrodes, HPB (Oxford).2017,19(12): 1058-.
At present, the two electrodes are mainly used for the tumor of the parenchymal organ such as liver, pancreas and kidney, however, the application of the hollow organ such as esophagus is less, and only the application of the flat plate electrode on the esophageal tissue is reported (Neven K, van Es R, van Driel V, et al. Acute and Long-Term Effects of Full-Power Electron Electroposition Abstract direct on the porous organ Evophagus. circ Arrhythm electrophysiol.2017,10(5). pi: e 004672). The two existing electrodes have obvious defects, on one hand, the application of the existing electrodes needs to expose visceral organs so as to facilitate the arrangement of the electrodes, so that the trauma to a patient is large, the body of a tumor patient is weak, the functions of the tumor patient are reduced, extra trauma is generated due to IRE ablation, and the recovery of the patient is greatly influenced; in addition, although the existing needle-type electrode can be placed under the real-time monitoring of ultrasound or CT through percutaneous puncture, the operation of the process is complex, and time and labor are wasted. The esophagus as a hollow organ has a special anatomical structure, is deep and is adjacent to important organs such as the heart, and the IRE ablation is carried out only by using the conventional electrode, so that great risk is caused. In addition, because the outer layer of the esophagus has no serosal layer, the injury is careless when the invasive ablation treatment is carried out, the poor healing of the wound, the occurrence of esophageal fistula and the like are easy to cause unnecessary injuries. At present, the two methods are difficult to apply on the esophagus and cannot ensure the non-invasive ablation of the esophagus IRE.
Therefore, according to the characteristics of the viscera of the esophagus, the design of the special electrode applied to the ablation of the esophageal cancer IRE has great significance.
Disclosure of Invention
The invention provides an invasive electrode for irreversible electroporation treatment of esophageal tumor tissues, which aims to solve the technical problems of complicated operation, poor wound healing and the like of esophageal cancer treatment by using the electrode in the prior art.
An invasive electrode for irreversible electroporation treatment of esophageal tumor tissue, comprising: the electrode comprises a fixed shell, a sheath, an electrode wire and an electrode;
the stationary housing is provided with a pulling mechanism arranged to be displaceable relative to the stationary housing,
the sheath is a flexible sheath and is provided with a hollow cavity, one end of the hollow cavity is connected with the fixed shell, and the other end of the hollow cavity is connected with the electrode sheath;
the electrode sheath is provided with an accommodating cavity, an electrode fixing ring is arranged in the accommodating cavity in a sliding manner, one end of the electrode fixing ring is connected with an electrode, the other end of the electrode fixing ring is abutted against one end of an elastic element, the elastic element is arranged in the accommodating cavity, and the other end of the elastic element is abutted against the electrode sheath;
the electrode wire penetrates through the hollow cavity of the sheath and the accommodating cavity of the electrode sheath, one end of the electrode wire is connected with the traction mechanism, and the other end of the electrode wire is connected with the electrode or the electrode fixing ring.
Preferably, the pulling mechanism is provided embedded in the stationary housing.
Preferably, the sheath and the electrode sheath are both provided as metal sheaths.
Preferably, the outer layer of the sheath is sprayed with a parylene coating.
Preferably, the elastic element is provided as a compression spring.
Preferably, a fixed stop block is further arranged in the accommodating cavity, and the other end of the elastic element abuts against the fixed stop block.
The invasive electrode for irreversible electroporation treatment of esophageal tumor tissues can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, is very suitable for the treatment of esophageal cancer, greatly reduces the risk of operation of a patient, and is beneficial to the surgical treatment of the patient.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic diagram of an invasive electrode for irreversible electroporation therapy of esophageal tumor tissue according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the following drawings in the embodiments of the present invention are connected to clearly and completely describe the technical solutions in the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, an invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to the present invention comprises: the fixed shell 10, the sheath 17, the electrode sheath 15, the electrode wire 18 and the electrode 11;
wherein the stationary housing 10 is arranged in connection with the casing 17, on which the pulling means 19 is arranged, the pulling means 19 being arranged displaceable relative to the stationary housing 10,
the sheath 17 is a flexible sheath and is provided with a hollow cavity, one end of the hollow cavity is connected with the fixed shell 10, and the other end of the hollow cavity is connected with the electrode sheath 15;
the electrode sheath 15 is connected to one end of the sheath 17, and has a housing cavity 15A, an electrode fixing ring 12 is slidably disposed in the housing cavity 15A, one end of the electrode fixing ring 12 is connected to the electrode 11, therefore, the electrode 11 can slide to the inside of the containing cavity 15A along with the electrode fixing ring 12, the electrode fixing ring 12 is connected with the electrode 11 to drive the electrode 11 to move, so as to ensure that the electrode 11 moves stably (the diameter of the electrode 11 is too small and the electrode 11 moves stably alone), the other end of the electrode fixing ring 12 abuts against one end of the elastic element 13, the elastic element 13 is arranged in the containing cavity 15A, the other end of the elastic element 13 abuts against the electrode sheath 15, in this embodiment, the containing cavity 15A is also internally provided with the fixed stop 14, the other end of the elastic element 13 abuts against the fixed stop, the elastic member 13 thus provides an elastic force to the electrode fixing ring 12 in the initial state, so that the electrode 11 can be forced to protrude outside the accommodation chamber 15A.
The electrode wire 18 penetrates through the hollow cavities of the sheath 17 and the electrode sheath 15, one end of the electrode wire 18 is connected with the traction mechanism 19, and the other end of the electrode wire 18 is connected with the electrode 11 or the electrode fixing ring 12, in this embodiment, the electrode wire 11 is connected to ensure acting force to the electrode 11, and in this connection mode, the electrode fixing ring 12 is provided with a hollow part or a through hole for the electrode wire 18 to penetrate through, so that the electrode 11 can be driven to move by pulling the electrode wire 18 when the traction mechanism 19 displaces, and the electrode wire can retract or extend out of the accommodating cavity.
In this embodiment, the pulling mechanism 19 is provided embedded in the stationary housing 10, which is convenient for operation.
In this embodiment, the sheath 17 and the electrode sheath 15 are both made of metal.
In this embodiment, the outer layer of the sheath 17 is coated with a parylene coating 16 for insulation from human tissue.
In this embodiment, the elastic member 13 is provided as a compression spring.
When the invasive electrode for irreversible electroporation therapy of esophageal tumor tissues is used, the invasive electrode is bound on an endoscope and reaches an esophageal tumor target point along with the endoscope, and when the endoscope enters a human body, an operator operates a traction mechanism 19 to contract an electrode 11 into an accommodating space 15A of an electrode sheath 15, so that the electrode is prevented from damaging human tissues. When the endoscope observes that the target site of the tumor tissue is reached, the operator operates the traction mechanism 19 to extend the electrode 11 out of the accommodating space 15A by the acting force of the elastic element 13 for treatment, and operates the traction mechanism 19 to retract the electrode 11 back into the accommodating space 15A after the treatment is finished, and then takes out the whole device.
The invention solves the requirement of flexibly and accurately constructing the required electric field when the irreversible electroporation treatment is carried out on the esophageal tumor tissue in a noninvasive mode, provides a portable and operable invasive electrode implementation scheme, can reach a target affected area along with an endoscope, accurately adjusts the electrode arrangement position and the insertion depth, and realizes a good treatment effect.
Finally, the invasive electrode for irreversible electroporation treatment of esophageal tumor tissues can realize non-invasive, accurate and convenient irreversible electroporation electrode arrangement, greatly reduce the difficulty of operating instruments during treatment, is very suitable for treatment of esophageal cancer, greatly reduces the risk of operation of a patient, and is beneficial to surgical treatment of the patient.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments or equivalent substitutions of some technical features may be made in the specification without departing from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (6)

1. An invasive electrode for irreversible electroporation treatment of esophageal tumor tissue, comprising: the electrode comprises a fixed shell, a sheath, an electrode wire and an electrode;
the stationary housing is provided with a pulling mechanism arranged to be displaceable relative to the stationary housing,
the sheath is a flexible sheath and is provided with a hollow cavity, one end of the hollow cavity is connected with the fixed shell, and the other end of the hollow cavity is connected with the electrode sheath;
the electrode sheath is provided with an accommodating cavity, an electrode fixing ring is slidably arranged in the accommodating cavity, one end of the electrode fixing ring is connected with an electrode, the other end of the electrode fixing ring is abutted against one end of an elastic element, the elastic element is arranged in the accommodating cavity, and the other end of the elastic element is abutted against the electrode sheath;
the electrode wire penetrates through the hollow cavity of the sheath and the accommodating cavity of the electrode sheath, one end of the electrode wire is connected with the traction mechanism, and the other end of the electrode wire is connected with the electrode or the electrode fixing ring.
2. The invasive electrode for irreversible electroporation therapy of esophageal tumor tissue according to claim 1, wherein the traction mechanism is configured to be embedded in the fixed housing.
3. An invasive electrode for irreversible electroporation treatment of esophageal tumor tissue according to claim 2, wherein the sheath and the electrode sheath are both provided as metal sheaths.
4. An invasive electrode according to claim 3, wherein the outer layer of the sheath is coated with parylene.
5. An invasive electrode according to claim 4, wherein the elastic member is configured as a compression spring.
6. An invasive electrode according to any one of claims 1 to 5, wherein a fixed stop is further disposed in the receiving cavity, and the other end of the elastic member abuts against the fixed stop.
CN202010748466.5A 2020-07-30 2020-07-30 Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues Pending CN111743621A (en)

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CN202010748466.5A CN111743621A (en) 2020-07-30 2020-07-30 Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues

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Application Number Priority Date Filing Date Title
CN202010748466.5A CN111743621A (en) 2020-07-30 2020-07-30 Invasive electrode for irreversible electroporation therapy of esophageal tumor tissues

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015405A (en) * 1998-01-20 2000-01-18 Tricardia, L.L.C. Device for forming holes in tissue
CN101495056A (en) * 2006-06-12 2009-07-29 京畿州海莱乌医院 Electrode introducer device
CN203089369U (en) * 2011-08-26 2013-07-31 苏州信迈医疗器械有限公司 Device used for mapping and ablation of renal nerves on renal artery
CN105101899A (en) * 2013-03-28 2015-11-25 奥林巴斯株式会社 Medical instrument and medical system
CN206745436U (en) * 2016-11-18 2017-12-15 宾心 Press telescopic high-frequency electrotome pen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015405A (en) * 1998-01-20 2000-01-18 Tricardia, L.L.C. Device for forming holes in tissue
CN101495056A (en) * 2006-06-12 2009-07-29 京畿州海莱乌医院 Electrode introducer device
CN203089369U (en) * 2011-08-26 2013-07-31 苏州信迈医疗器械有限公司 Device used for mapping and ablation of renal nerves on renal artery
CN105101899A (en) * 2013-03-28 2015-11-25 奥林巴斯株式会社 Medical instrument and medical system
CN206745436U (en) * 2016-11-18 2017-12-15 宾心 Press telescopic high-frequency electrotome pen

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