CN111602816A - Clinacanthus nutans composite functional food and application thereof in preventing and treating pancreatic cancer - Google Patents
Clinacanthus nutans composite functional food and application thereof in preventing and treating pancreatic cancer Download PDFInfo
- Publication number
- CN111602816A CN111602816A CN202010360378.8A CN202010360378A CN111602816A CN 111602816 A CN111602816 A CN 111602816A CN 202010360378 A CN202010360378 A CN 202010360378A CN 111602816 A CN111602816 A CN 111602816A
- Authority
- CN
- China
- Prior art keywords
- clinacanthus nutans
- ethanol
- clinacanthus
- functional food
- nutans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000123852 Clinacanthus nutans Species 0.000 title claims abstract description 189
- 235000013376 functional food Nutrition 0.000 title claims abstract description 66
- 206010061902 Pancreatic neoplasm Diseases 0.000 title claims abstract description 36
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title claims abstract description 36
- 201000002528 pancreatic cancer Diseases 0.000 title claims abstract description 36
- 208000008443 pancreatic carcinoma Diseases 0.000 title claims abstract description 36
- 239000002131 composite material Substances 0.000 title claims abstract description 34
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 82
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 27
- 150000001875 compounds Chemical class 0.000 claims abstract description 25
- 244000248349 Citrus limon Species 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 188
- 238000010828 elution Methods 0.000 claims description 54
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- 229920005989 resin Polymers 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 3
- 238000011068 loading method Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 21
- 244000131522 Citrus pyriformis Species 0.000 description 22
- 235000019658 bitter taste Nutrition 0.000 description 19
- 239000002244 precipitate Substances 0.000 description 15
- 230000002946 anti-pancreatic effect Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 235000019606 astringent taste Nutrition 0.000 description 6
- 238000001035 drying Methods 0.000 description 6
- 239000001963 growth medium Substances 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 4
- 235000015203 fruit juice Nutrition 0.000 description 4
- 235000004936 Bromus mango Nutrition 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 240000007228 Mangifera indica Species 0.000 description 3
- 235000014826 Mangifera indica Nutrition 0.000 description 3
- 239000012980 RPMI-1640 medium Substances 0.000 description 3
- 235000009184 Spondias indica Nutrition 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 235000015197 apple juice Nutrition 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000019674 grape juice Nutrition 0.000 description 3
- 235000015205 orange juice Nutrition 0.000 description 3
- 235000013997 pineapple juice Nutrition 0.000 description 3
- 241000270728 Alligator Species 0.000 description 2
- 241000755731 Clintonia Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 241000207965 Acanthaceae Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241001579122 Clinacanthus Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 description 1
- PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010360378.8A CN111602816A (en) | 2020-04-30 | 2020-04-30 | Clinacanthus nutans composite functional food and application thereof in preventing and treating pancreatic cancer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010360378.8A CN111602816A (en) | 2020-04-30 | 2020-04-30 | Clinacanthus nutans composite functional food and application thereof in preventing and treating pancreatic cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111602816A true CN111602816A (en) | 2020-09-01 |
Family
ID=72194671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010360378.8A Pending CN111602816A (en) | 2020-04-30 | 2020-04-30 | Clinacanthus nutans composite functional food and application thereof in preventing and treating pancreatic cancer |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111602816A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
CN110150519A (en) * | 2019-06-18 | 2019-08-23 | 珠海霍普金斯医药研究院股份有限公司 | A kind of sorrow, which is escaped, careless extract and preparation method thereof and is preparing the application in functional food |
-
2020
- 2020-04-30 CN CN202010360378.8A patent/CN111602816A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105341570A (en) * | 2015-10-14 | 2016-02-24 | 哈尔滨工业大学 | Series Clinacanthus nutans functional beverage and preparation method thereof |
CN110150519A (en) * | 2019-06-18 | 2019-08-23 | 珠海霍普金斯医药研究院股份有限公司 | A kind of sorrow, which is escaped, careless extract and preparation method thereof and is preparing the application in functional food |
Non-Patent Citations (1)
Title |
---|
李本高主编: "《现代工业水处理技术与应用》", 30 June 2004, 北京:中国石化出版社 * |
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Legal Events
Date | Code | Title | Description |
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PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210603 Address after: 519000 building 17, creative Valley, Huandao East Road, Hengqin New District, Zhuhai City, Guangdong Province Applicant after: ZHUHAI HOPEGENES MEDICAL AND PHARMACEUTICAL INSTITUTE Co.,Ltd. Address before: 519000 unit 1, 33 Haihe street, Hengqin New District, Zhuhai City, Guangdong Province Applicant before: ZHUHAI DAHENGQIN TECHNOLOGY DEVELOPMENT Co.,Ltd. Applicant before: ZHUHAI HOPEGENES MEDICAL AND PHARMACEUTICAL INSTITUTE Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20211217 Address after: 518101 1303, building 8, Qianhai excellence Financial Center (phase I), unit 2, guiwan area, Nanshan street, Qianhai Shenzhen Hong Kong cooperation zone, Shenzhen, Guangdong Applicant after: Lide Laifu (Shenzhen) Biotechnology Co.,Ltd. Address before: 519000 building 17, creative Valley, Huandao East Road, Hengqin New District, Zhuhai City, Guangdong Province Applicant before: ZHUHAI HOPEGENES MEDICAL AND PHARMACEUTICAL INSTITUTE, CO.,LTD. |