CN111529564B - 一种红景天中低极性活性成分及其制备方法 - Google Patents
一种红景天中低极性活性成分及其制备方法 Download PDFInfo
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- CN111529564B CN111529564B CN202010427288.6A CN202010427288A CN111529564B CN 111529564 B CN111529564 B CN 111529564B CN 202010427288 A CN202010427288 A CN 202010427288A CN 111529564 B CN111529564 B CN 111529564B
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- rhodiola rosea
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- ethyl acetate
- rhodiola
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- 235000003713 Rhodiola rosea Nutrition 0.000 title claims abstract description 127
- 239000004480 active ingredient Substances 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title abstract description 23
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 105
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 58
- 239000000843 powder Substances 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 35
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- 239000012046 mixed solvent Substances 0.000 claims abstract description 21
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 8
- 238000002137 ultrasound extraction Methods 0.000 claims description 14
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims description 3
- 239000000544 cholinesterase inhibitor Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 abstract description 42
- 239000002904 solvent Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 19
- 102000012440 Acetylcholinesterase Human genes 0.000 abstract description 15
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract description 15
- 229940022698 acetylcholinesterase Drugs 0.000 abstract description 15
- 230000003078 antioxidant effect Effects 0.000 abstract description 11
- 230000005764 inhibitory process Effects 0.000 abstract description 10
- 239000013543 active substance Substances 0.000 abstract description 9
- 230000002401 inhibitory effect Effects 0.000 abstract description 8
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 abstract description 4
- 230000007760 free radical scavenging Effects 0.000 abstract description 3
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- 238000002474 experimental method Methods 0.000 description 21
- 239000003814 drug Substances 0.000 description 18
- 239000007788 liquid Substances 0.000 description 18
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 241001165494 Rhodiola Species 0.000 description 11
- 238000005303 weighing Methods 0.000 description 10
- 239000000284 extract Substances 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 6
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 5
- 229930014626 natural product Natural products 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000001819 mass spectrum Methods 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 210000004958 brain cell Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 238000005457 optimization Methods 0.000 description 2
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- 238000012360 testing method Methods 0.000 description 2
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- 238000003809 water extraction Methods 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- 241000220284 Crassulaceae Species 0.000 description 1
- -1 DPPH free radical Chemical class 0.000 description 1
- 241000380130 Ehrharta erecta Species 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
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- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
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- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
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- 238000001959 radiotherapy Methods 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
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CN111529564B true CN111529564B (zh) | 2022-05-03 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009151173A1 (en) * | 2008-06-12 | 2009-12-17 | Korea Research Institute Of Bioscience And Biotechnology | Pharmaceutical compositions for prevention and treatment of viral diseases containing rhodiola extracts, fractions, the isolated flavonoid compounds therefrom, derivatives compounds thereof or the pharmaceutically acceptable salts as an active ingredient |
CN103059075A (zh) * | 2012-12-13 | 2013-04-24 | 大兴安岭林格贝有机食品有限责任公司 | 一种从红景天中分离纯化红景天苷的生产方法 |
CN103814954A (zh) * | 2014-02-27 | 2014-05-28 | 北京农学院 | 红景天提取物及其制备方法与应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2859102B1 (fr) * | 2003-08-28 | 2008-01-18 | Coletica | Utilisation d'un extrait de rhodiola crenulata par voie topique |
CN106265342A (zh) * | 2016-09-19 | 2017-01-04 | 东莞自然衡健康科技有限公司 | 一种红景天抗氧化抗皱提取液的制备方法及其应用 |
-
2020
- 2020-05-19 CN CN202010427288.6A patent/CN111529564B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009151173A1 (en) * | 2008-06-12 | 2009-12-17 | Korea Research Institute Of Bioscience And Biotechnology | Pharmaceutical compositions for prevention and treatment of viral diseases containing rhodiola extracts, fractions, the isolated flavonoid compounds therefrom, derivatives compounds thereof or the pharmaceutically acceptable salts as an active ingredient |
CN103059075A (zh) * | 2012-12-13 | 2013-04-24 | 大兴安岭林格贝有机食品有限责任公司 | 一种从红景天中分离纯化红景天苷的生产方法 |
CN103814954A (zh) * | 2014-02-27 | 2014-05-28 | 北京农学院 | 红景天提取物及其制备方法与应用 |
Non-Patent Citations (4)
Title |
---|
周思思.红景天中有效成分的分离纯化、鉴定及其活性研究.《中国优秀硕士学位论文数据库医药卫生科技辑》.2019,(第01期),第E057-106. * |
大株红景天化学成分的研究;赵娜;《天津医科大学学报》;20160331;第3卷(第2期);第119-121,125页 * |
红景天中有效成分的分离纯化、鉴定及其活性研究;周思思;《中国优秀硕士学位论文数据库医药卫生科技辑》;20190115(第01期);第E057-106页 * |
红景天苷对帕金森病轻度认知功能损害改善作用的研究;陈钧;《中华中医药杂志》;20190630;第34卷(第6期);第2455-2459页 * |
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Effective date of registration: 20230328 Address after: Room 701, Zhongchuang Space Building, 100 meters east of Chagu Avenue, Liuwu New District, Lhasa, Tibet Autonomous Region, 851414 Patentee after: Tibetan Tibetan Nobel Tibetan Pharmaceutical Technology Co.,Ltd. Address before: 1 / F, No. 436, Lingke Road, Jinjiang District, Chengdu, Sichuan 610011 Patentee before: Chengdu Zhifu Enterprise Management Co.,Ltd. Effective date of registration: 20230328 Address after: 1 / F, No. 436, Lingke Road, Jinjiang District, Chengdu, Sichuan 610011 Patentee after: Chengdu Zhifu Enterprise Management Co.,Ltd. Address before: 524088 No. 1 Haida Road, Mazhang District, Zhanjiang City, Guangdong Province Patentee before: Guangdong Ocean University Patentee before: SHENZHEN INSTITUTE OF GUANGDONG OCEAN University |
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Effective date of registration: 20230922 Address after: No. 18 Puzhang Road, Shigatse City, Tibet Autonomous Region, 857012 Patentee after: Tibet Tibetan pharmaceutical Limited by Share Ltd. Address before: Room 701, Zhongchuang Space Building, 100 meters east of Chagu Avenue, Liuwu New District, Lhasa, Tibet Autonomous Region, 851414 Patentee before: Tibetan Tibetan Nobel Tibetan Pharmaceutical Technology Co.,Ltd. |