CN111494598A

CN111494598A - Oral and external traditional Chinese medicine for treating liver-stagnation and spleen-deficiency type acne and preparation method thereof

Info

Publication number: CN111494598A
Application number: CN202010491285.9A
Authority: CN
Inventors: 郭宝云; 吴正博
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-02
Filing date: 2020-06-02
Publication date: 2020-08-07

Abstract

The invention relates to an oral and external traditional Chinese medicine for treating liver-stagnation and spleen-deficiency acne and a preparation method thereof, wherein the oral and external traditional Chinese medicine comprises the following main components in parts by weight: 5-10 parts of radix bupleuri, 5-10 parts of radix scutellariae, 5-10 parts of cassia twig, 5-10 parts of dried ginger, 5-10 parts of radix angelicae, 15-20 parts of flos lonicerae, 10-15 parts of dandelion, 20-25 parts of raw oyster, 10-20 parts of poria cocos, and 5-10 parts of radix salviae miltiorrhizae. The prescription is 1 dose, the first decoction is carried out for 2.5 bowls, and the decoction is carried out for eight minutes; decocting the residues in 2 bowls of water for six minutes, and taking in the morning and evening. The traditional Chinese medicine is clinically applied, has obvious effect, is safe and has no toxic or side effect, and is suitable for being developed and developed into granules, oral liquid, capsules, tablets, bagged steeping agents and the like which are convenient to carry and take by applying the modern pharmaceutical technology.

Description

Oral and external traditional Chinese medicine for treating liver-stagnation and spleen-deficiency type acne and preparation method thereof

Technical Field

The invention relates to an oral and external traditional Chinese medicine for treating acne caused by liver depression and spleen deficiency, in particular to an oral and external traditional Chinese medicine for treating acne caused by liver depression and spleen deficiency and a preparation method thereof.

Background

The traditional Chinese medicine for treating acne is named as 'lung wind acne', and most doctors think that the acne is caused by excessive essence and yang and wind-heat of lung meridian along the channel; or overeating spicy, fat and sweet food to cause damp-heat to be generated internally, and the damp-heat of the stomach and intestine is steamed along the channels; or spleen deficiency failing to transport, dampness accumulating into phlegm, damp stagnation transforming into heat, damp-heat obstructing the meridians and collaterals with phlegm and remaining in the skin. The treatment is mainly to clear away heat and toxic material, and relieve swelling and dissipate nodulation. However, the clinical cases with mixed chills and fever are not rare, and the acne is marked by stagnation of liver qi, spleen deficiency and phlegm coagulation, the qi of shaoyang pivot moves up and down and spreads to the inside and outside, if the pathogenic factors stagnate shaoyang, the pivot is unfavorable, and the stagnation causes fever; the spleen deficiency and the transportation and transformation disorder, phlegm-dampness and endogenous dampness, which are combined, result in acne.

The traditional prescription mainly takes the medicines for clearing heat and removing toxicity, and relieving swelling and expelling pus, such as Ruyi Jinhuang san and Puji Xiaodu Yin, and the like, although the symptoms can be temporarily relieved, the relapse is easy to happen after the medicine is stopped, and the radical cure is difficult to achieve. Therefore, the traditional Chinese medicine for treating the acne with the syndrome of liver depression and spleen deficiency by oral administration and external application and the preparation method thereof are specially designed.

Disclosure of Invention

In order to overcome the defects, the invention provides an oral and external traditional Chinese medicine for treating liver depression and spleen deficiency type acne and a preparation method thereof.

The technical scheme adopted by the invention for solving the technical problems is as follows: an oral and external traditional Chinese medicine for treating liver-stagnation and spleen-deficiency acne is characterized by comprising the following raw material medicines in parts by weight:

5-10 parts of radix bupleuri, 5-10 parts of radix scutellariae, 5-10 parts of cassia twig, 5-10 parts of dried ginger, 5-10 parts of radix angelicae, 15-20 parts of smallpox, 10-15 parts of dandelion, 20-25 parts of raw oyster, 10-20 parts of poria cocos and 5-10 parts of radix salviae miltiorrhizae.

The traditional Chinese medicine formula disclosed by the invention has the effects of soothing liver, regulating qi, strengthening spleen and eliminating dampness, and is mainly used for treating acne caused by liver depression and spleen deficiency, clinically seen flushing of face skin color, papule damage, pustule or cyst, accompanied with anorexia, loose stool, pale and moist or pale and swollen tongue and wiry and smooth pulse.

Radix bupleuri, bitter and pungent in flavor and slightly cold in nature, belongs to pericardium, liver, triple energizer and gallbladder channels, has the effects of relieving and allaying fever, soothing liver and relieving depression and lifting yang qi, and is mainly used for clearing and relieving shaoyang gallbladder heat and treating acne caused by stagnation of liver qi and transformation of qi depression into fire in the formula. Modern pharmacology considers that the bupleurum has the effects of relieving fever, easing pain, resisting inflammation, protecting liver, benefiting gallbladder, improving immunity and the like. The scutellaria baicalensis is bitter in taste and cold in nature, enters lung, gallbladder, stomach and large intestine channels, has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding and preventing miscarriage, and is combined with the bupleurum in the formula to clear away shaoyang gallbladder heat and enhance the effects of soothing liver and clearing heat. Modern pharmacology considers that the scutellaria baicalensis has wide antimicrobial spectrum, has an inhibiting effect on various dermatophytes, staphylococcus, streptococcus, pseudomonas aeruginosa and the like, and also has the effects of protecting liver and benefiting gallbladder.

Cassia twig, pungent and sweet in flavor and warm in nature, enters heart, kidney and bladder meridians, has the effects of inducing sweat, relieving exterior syndrome, warming meridians, activating yang and warming and invigorating yang qi, and has the effects of stimulating yang qi and dissipating stagnated heat in the recipe for spleen deficiency. Modern pharmacology considers that cassia twig has the effects of relieving fever, easing pain, resisting inflammation, resisting allergy, resisting pathogenic microorganisms and the like, and the cassia twig volatile oil has the effect of inhibiting acute inflammation caused by various inflammatory substances.

The dried ginger is pungent in property and hot in property, enters spleen, stomach, heart and lung channels, has the effects of warming spleen and stomach for dispelling cold, restoring yang and dredging collaterals, and warming lung to resolve retention of fluid, and plays a role in warming spleen and supporting yang in the recipe. Modern pharmacology considers that the dried ginger has obvious anti-inflammatory effect and strong inhibition effect on staphylococcus, streptococcus, pneumococcus and the like.

Radix angelicae has pungent and warm nature and flavor, enters lung and stomach, relieves exterior syndrome, has the effects of dispelling wind, eliminating dampness, relieving swelling, expelling pus and relieving pain, and has the functions of relieving swelling and expelling pus in the recipe. Modern pharmacology considers that the angelica dahurica has pharmacological effects of relieving fever, relieving spasm, easing pain, resisting bacteria and the like.

Smallpox is bitter in nature and slightly sweet in flavor, and cold in nature, enters lung and stomach, has the efficacies of clearing heat and promoting fluid, and relieving swelling and expelling pus, and has the functions of relieving swelling and expelling pus in the recipe. Modern pharmacology considers that smallpox has the effects of resisting bacteria, viruses, immunity, tumors and the like.

Dandelion, bitter in flavor, sweet and cold in nature, entering liver and stomach, has the effects of clearing heat and removing toxicity, relieving swelling and expelling pus, and inducing diuresis, and has the actions of relieving swelling and expelling pus in the recipe. Modern pharmacology considers that the dandelion has antibacterial and antiviral effects, and has inhibitory effects on staphylococcus aureus, hemolytic streptococcus, pneumococcus, pseudomonas aeruginosa, modified bacillus, catacoccus, tubercle bacillus, influenza virus and various dermatophytes.

Oyster is salty in flavor and slightly cold in nature, enters liver and kidney, has the effects of calming liver, suppressing yang hyperactivity, softening hardness to dissipate stagnation, astringing and arresting discharge, and plays a role in softening hardness to dissipate stagnation in the recipe. Modern pharmacology considers the effects of tranquilizing, softening hard masses, relieving fever, protecting liver, enhancing immunity and the like.

Poria cocos is sweet, bland and neutral in nature and flavor, has the effects of benefiting heart, spleen and kidney, promoting diuresis, eliminating dampness, invigorating spleen and soothing nerves, and has the effect of invigorating spleen to eliminate dampness in the recipe. Modern pharmacology considers that tuckahoe has the effects of bacteriostasis, anti-inflammation, antivirus, immunoregulation, diuresis and the like.

Salvia miltiorrhiza, bitter in flavor and slightly cold in nature, has the effects of activating blood circulation to dissipate blood stasis, cooling blood to cure carbuncle and soothing the nerves, and is also called as activating blood circulation to cure carbuncle in the recipe, and the heart, pericardium and liver are all the attributes of the recipe. Modern pharmacology considers that the salvia miltiorrhiza has the effects of resisting bacteria and inflammation, improving microcirculation and improving liver and kidney functions.

The preparation method comprises the following steps:

1. decoction: 10 parts of radix bupleuri, 10 parts of cassia twig, 10 parts of radix scutellariae, 5 parts of rhizoma zingiberis, 10 parts of radix angelicae, 20 parts of raw oyster shell, 10 parts of smallpox, 10 parts of poria cocos, 10 parts of dandelion and 10 parts of radix salviae miltiorrhizae, the medicinal materials are cleaned and placed into a ceramic or enamel container, 750 milliliters of water is added, then the medicinal materials are boiled with big fire, decocted with small fire to 600 milliliters of water, and medicinal liquor is decanted for later use; adding 600 ml of water, boiling the mixture for a long time, decocting the mixture with slow fire to 360 ml of water, and decanting the decoction for later use, wherein 1 dose of the decoction is taken in the morning and at night every day; external washing: adding 200 plus 360 ml of water into the medicinal materials, decocting for 5 minutes by strong fire, and decanting the decoction for later use.

2. And (3) particle: concentrating the decoction to 20-30%, drying, spray drying at the actual temperature of 35-50 deg.C for several seconds or tens of seconds, and packaging with aluminum-plastic composite bag for sterilization.

3. And (3) capsule preparation: grinding the granular medicine prepared by the above granule processing method, making into powder, uniformly packaging, and making into hard capsule.

4. Oral liquid: extracting effective components from the decoction, adding additives, and making into oral liquid by injection process.

5. And (3) tablet preparation: the granules prepared by the granule processing method are mixed with the lubricant evenly and then put into a tablet machine for tabletting, thus preparing the tablets.

6. Bag soaking agent: the granular medicine prepared by the above granule processing method is filled into a small nontoxic filter bag, and the mouth is sealed, and then the medicine is packaged with an outer packaging bag.

The administration method comprises the following steps:

cleaning the above medicinal materials, putting into a ceramic or enamel container, adding 750 ml of water, decocting for the first time, decanting the decoction after decocting to 600 ml of water, and taking the decoction while it is hot; adding 600 ml of water into the medicinal materials again at night, decocting to 360 ml of water, decanting the decoction, and taking the decoction while it is hot; then adding 360 ml of 200-.

The invention adopts the treatment principle of soothing liver, regulating qi, strengthening spleen and eliminating dampness according to the mechanism characteristics of liver depression and spleen deficiency type acne. In the formula, the radix bupleuri and the radix scutellariae relieve shaoyang gallbladder heat; dahurian angelica root, smallpox, dandelion are used for detumescence and pus discharge; raw oyster shell can soften hardness and dissipate stagnation; ramulus Cinnamomi disperses stagnated heat; the dried ginger warms the spleen and strengthens yang; poria strengthens the spleen to eliminate dampness, and Salvia miltiorrhiza activates blood to cure carbuncle. Is a good medicine for treating acne caused by liver depression and spleen deficiency.

The specific implementation mode is as follows:

the present invention is described in further detail below with reference to examples, but the embodiments of the present invention are not limited thereto.

Example 1

10 parts of radix bupleuri, 10 parts of cassia twig, 10 parts of radix scutellariae, 5 parts of rhizoma zingiberis, 10 parts of radix angelicae, 20 parts of raw oyster shell, 10 parts of smallpox, 10 parts of poria cocos, 10 parts of dandelion and 10 parts of radix salviae miltiorrhizae, the medicinal materials are cleaned and placed into a ceramic or enamel container, 750 milliliters of water is added, then the medicinal materials are boiled with big fire, decocted with small fire to 600 milliliters of water, and medicinal liquor is decanted for later use; adding 600 ml of water, boiling the mixture for a long time, decocting the mixture with slow fire to 360 ml of water, and decanting the decoction for later use, wherein 1 dose of the decoction is taken in the morning and at night every day; external washing: adding 200 plus 360 ml of water into the medicinal materials, decocting for 5 minutes by strong fire, and decanting the decoction for later use.

The preparation method of the decoction, the granule, the oral liquid, the capsule, the tablet and the bagged preparation comprises the following steps:

The administration method comprises the following steps:

Clinical cases

The following cases are all used to verify the curative effect of the traditional Chinese medicine prepared in example 1 and used for treating acne caused by liver depression and spleen deficiency by oral administration and external application.

General data of patients who written in 2019 and clinically treated 74 cases of liver depression and spleen deficiency type acne, wherein 11 cases of men and 63 cases of women are provided; the minimum age is 15 years old, the maximum age is 56 years old, and the maximum age is 17-26 years old; the shortest disease course is 2 months, and the longest disease course is 6 years.

The diagnosis is based on the principle that red papules with small grain sizes are formed at the hair follicle opening at the beginning according to the 'standard of curative effect for diagnosing the traditional Chinese medicine diseases' (1), and the papules can also develop into pustules. After this time, a scleroid white or black comedo may form, and in severe cases, a sclerosing cyst may form. (2) It is usually seen on the face, chest and back of male and female in adolescence, accompanied by seborrhea. (3) It is often induced by improper diet, overeating a thick, greasy taste, or an attack from exogenous pathogens. (4) After adolescence, most of them can be relieved naturally. (5) Women often have irregular menstruation.

The clinical symptoms include flushing of the face, papule damage, pustule or cyst, anorexia, loose stool, pale and moist or pale and swollen tongue, and wiry and smooth pulse, which are the syndromes of liver depression and spleen deficiency.

Method of treatment

The formula of the radix bupleuri, cassia twig and dried ginger decoction plus jiajiajiajiajiajia base is taken orally: radix bupleuri, cassia twig, 10 baical skullcap root, 10 dried ginger, 5 dahurian angelica root, 10 raw oyster, 20 common peony root, 10 Indian buead, 10 Mongolian dandelion herb, 10 danshen root. Decocting 1 dose daily in 2.5 bowls of water for eight minutes; decocting the residues in 2 bowls of water for six minutes, and taking in the morning and evening.

Washing, decocting with small amount of water for 5 min, and washing with facial cleanser or wet compress once a day for 10-15 min each time.

The life is regular and the person does not stay up; the spicy and greasy food and the wine are not eaten, and the vegetables and fruits are eaten more; regulating emotion; keeping the defecation smooth.

Observation of therapeutic effects

The judgment of curative effect "standard of curative effect for diagnosis of disease and syndrome of traditional Chinese medicine" (1) cure: the skin lesions subside and the subjective symptoms disappear. Improvement: the subjective symptoms are obviously relieved, and the skin damage is reduced by more than 30 percent. The disease is not cured: there was no change in skin lesions or less than 30% regression of symptoms.

The treatment results are 59 cases (79.73 percent) cured, 13 cases (17.57 percent) improved and 2 cases (2.70 percent) unhealed. The minimum dose was 7 doses, the maximum 28 doses, and the average 18 doses; the fastest person is improved for 6 days, the slowest person is improved for 28 days, and the average day is 17 days. No toxic or side effect is found.

Examples of medical cases

Case one: high a certain person, woman, 21, student. 2019. 4, 16 initial diagnosis. Acne is repeated for three or four years, poor sleep, throat peduncle, cold limbs, normal stool, pale and moist tongue, slight blood stasis under tongue, and slippery pulse. The traditional Chinese medicine is prepared by adding radix bupleuri, cassia twig and dried ginger decoction into a prescription for diagnosing acne (liver depression and spleen deficiency syndrome), wherein the prescription comprises the following components: 10 parts of radix bupleuri, 10 parts of cassia twig, 10 parts of scutellaria baicalensis, 10 parts of rhizoma pinelliae preparata, 10 parts of smallpox, 20 parts of raw oyster, 10 parts of mangnolia officinalis, 20 parts of poria cocos, 10 parts of dandelion, 10 parts of angelica sinensis, 10 parts of amomum cardamomum and 10 parts of salvia miltiorrhiza. Seven doses, the first two are decocted with water for oral administration, the third one is decocted with water for external washing, and the patient can be cured after one week without further treatment.

Case two: chua a certain, woman, 18, student. 2019. 7, 3, initial diagnosis. Since the first 6 years of primary school, the patient has acne, and the patient is easy to constipation, pale and swollen tongue, sublingual stasis and blockage, and smooth and rapid pulse due to the stress of learning, insufficient sleep, and blood clots. According to the traditional Chinese medicine, the formula of the pseudo-diagnosis acne (the syndrome of liver depression and spleen deficiency with blood stasis) is modified by bupleurum-cassia twig-dried ginger decoction, and the formula comprises the following components: cassia twig 5, bupleurum 10, raw oyster 20, dandelion 10, trichosanthes 10, tuckahoe 10, red sage 10, raw atractylodes 30, dried rehmannia root 10, figwort 10 and angelica 10. Seven doses, the first two are decocted with water for oral administration, and the third is decocted with water for external washing. In the second treatment, the symptoms are relieved, roses 10 are added above the herbs to order the patients to pay attention to emotion and mind conditioning, and the patients can be healed after being fed back.

Case three: zheng somewhere, Man, 32, clerk. 2019. 5, 10 initial diagnosis. Repeated acne for two years, which is distributed on face and scalp, has strong body, cold limbs in winter, loose stool, red, fat tongue tip, white and thick fur, slight blood stasis under tongue, and wiry and smooth pulse. According to the traditional Chinese medicine, the formula of the pseudo-diagnosis acne (syndrome of liver depression and spleen deficiency with phlegm) is modified by bupleurum-cassia twig-dried ginger decoction, and the formula comprises the following components:

10 parts of radix bupleuri, 10 parts of cassia twig, 5 parts of dried ginger, 20 parts of raw oyster, 10 parts of radix angelicae, 10 parts of dried orange peel, 10 parts of mangnolia officinalis, 10 parts of poria cocos, 10 parts of radix salviae miltiorrhizae, 10 parts of fried bighead atractylodes rhizome, 10 parts of platycodon grandiflorum and 10 parts of dandelion. Seven doses, the first two are decocted with water for oral administration, the third one is decocted with water for external washing, and 21 doses of the common formula are used for curing the disease.

Clinical application shows that the traditional Chinese medicine can obviously relieve the clinical symptoms of the acne with the syndrome of liver depression and spleen deficiency,

the traditional Chinese medicine is clinically applied, has obvious effect, is safe and has no toxic or side effect, and is suitable for being developed into granules, oral liquid, capsules, tablets, bagged steeping agents and the like which are convenient to carry and take by applying the modern pharmaceutical technology.

Claims

1. An oral and external traditional Chinese medicine for treating liver-stagnation and spleen-deficiency acne is characterized by comprising the following raw material medicines in parts by weight:

2. The preparation method of the oral and external traditional Chinese medicine for treating the acne with the syndrome of liver depression and spleen deficiency as claimed in claim 1 is characterized in that: 10 parts of radix bupleuri, 10 parts of cassia twig, 10 parts of radix scutellariae, 5 parts of rhizoma zingiberis, 10 parts of radix angelicae, 20 parts of raw oyster shell, 10 parts of smallpox, 10 parts of poria cocos, 10 parts of dandelion and 10 parts of radix salviae miltiorrhizae, the medicinal materials are cleaned and placed into a ceramic or enamel container, 750 milliliters of water is added, then the medicinal materials are boiled with big fire, decocted with small fire to 600 milliliters of water, and medicinal liquor is decanted for later use; adding 600 ml of water, boiling the mixture for a long time, decocting the mixture with slow fire to 360 ml of water, and decanting the decoction for later use, wherein 1 dose of the decoction is taken in the morning and at night every day; external washing: adding 200 plus 360 ml of water into the medicinal materials, decocting for 5 minutes by strong fire, and decanting the decoction for later use.

3. The method for taking the traditional Chinese medicine for treating the acne with the syndrome of liver depression and spleen deficiency by oral administration and external application according to claim 2 is characterized in that: cleaning the above medicinal materials, putting into a ceramic or enamel container, adding 750 ml of water, decocting for the first time, decanting the decoction after decocting to 600 ml of water, and taking the decoction while it is hot; adding 600 ml of water into the medicinal materials again at night, decocting to 360 ml of water, decanting the decoction, and taking the decoction while it is hot; then adding 360 ml of 200-.

4. The orally-taken and externally-applied traditional Chinese medicine for treating the acne with the syndrome of liver depression and spleen deficiency as claimed in claim 1, which is characterized by comprising granules, oral liquid, capsules, tablets and bagged steeping agents.