CN111494454B - 一种治疗间质性肺病的药物组合物 - Google Patents
一种治疗间质性肺病的药物组合物 Download PDFInfo
- Publication number
- CN111494454B CN111494454B CN202010557283.5A CN202010557283A CN111494454B CN 111494454 B CN111494454 B CN 111494454B CN 202010557283 A CN202010557283 A CN 202010557283A CN 111494454 B CN111494454 B CN 111494454B
- Authority
- CN
- China
- Prior art keywords
- parts
- filtering
- mixing
- pharmaceutical composition
- interstitial lung
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000029523 Interstitial Lung disease Diseases 0.000 title claims abstract description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 244000035851 Chrysanthemum leucanthemum Species 0.000 claims abstract description 11
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 244000078912 Trichosanthes cucumerina Species 0.000 claims abstract description 9
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 7
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims abstract description 7
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims abstract description 5
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 4
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 4
- 229940107666 astragalus root Drugs 0.000 claims abstract description 4
- 229940010454 licorice Drugs 0.000 claims abstract description 4
- 239000000706 filtrate Substances 0.000 claims description 36
- 239000003814 drug Substances 0.000 claims description 26
- 238000002156 mixing Methods 0.000 claims description 25
- 238000011282 treatment Methods 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- 239000009636 Huang Qi Substances 0.000 claims description 7
- 241000243684 Lumbricus Species 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 235000006533 astragalus Nutrition 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 238000007796 conventional method Methods 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
- 235000011477 liquorice Nutrition 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 241001061264 Astragalus Species 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 210000004233 talus Anatomy 0.000 claims description 3
- 235000000934 Trichosanthes dioica Nutrition 0.000 claims description 2
- 240000006023 Trichosanthes kirilowii Species 0.000 claims description 2
- 235000009818 Trichosanthes kirilowii Nutrition 0.000 claims description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 claims 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 206010011224 Cough Diseases 0.000 abstract description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 4
- 208000026435 phlegm Diseases 0.000 abstract description 4
- 238000003908 quality control method Methods 0.000 abstract description 3
- 230000009467 reduction Effects 0.000 abstract description 3
- 230000004202 respiratory function Effects 0.000 abstract description 3
- 206010061818 Disease progression Diseases 0.000 abstract description 2
- 230000005750 disease progression Effects 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 abstract 1
- 230000003111 delayed effect Effects 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 208000011580 syndromic disease Diseases 0.000 description 9
- 230000007812 deficiency Effects 0.000 description 7
- 230000004199 lung function Effects 0.000 description 5
- 208000019693 Lung disease Diseases 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000005069 pulmonary fibrosis Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000045403 Astragalus propinquus Species 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000000750 progressive effect Effects 0.000 description 3
- -1 anti-fibrosis Substances 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 241001116477 Adenophora triphylla Species 0.000 description 1
- 241000382455 Angelica sinensis Species 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 241000007126 Codonopsis pilosula Species 0.000 description 1
- 208000035240 Disease Resistance Diseases 0.000 description 1
- 208000024869 Goodpasture syndrome Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000002300 anti-fibrosis Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 238000011976 chest X-ray Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 208000010758 granulomatous inflammation Diseases 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 206010035653 pneumoconiosis Diseases 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009325 pulmonary function Effects 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000003156 vasculitic effect Effects 0.000 description 1
- 230000003519 ventilatory effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种治疗间质性肺病的药物组合物及其制备方法。该组合物由黄芪10‑15、生甘草10‑15、地龙6‑10、野菊花5‑8和瓜蒌1‑5组成。组方简单,利于产品质量控制以及生产成本的降低,同时还能止咳化痰,有效改善患者呼吸功能、提高患者生存质量,延缓病症进展,且无明显副作用。
Description
技术领域
本发明涉及中药领域,更具体地,一种治疗间质性肺病的药物组合物。
背景技术
间质性肺病又称肺间质病、弥漫性实质性肺病或侵袭性肺病,由一大组异质性肺病组成,包括原因已明和原因不明两大类。原因已明类主要包括因职业环境引起的尘肺病、外源性过敏性肺炎等,或药物诱发引起。原因不明类则包括特发性肺间质纤维化、肺出血肾炎综合征、结节病等。临床表现通常为进行性呼吸困难、干咳、喘息等,胸部X射线表现为双肺弥漫性的网状、结节状或细结节状浸润性阴影,组织学特点显示非肿瘤性的炎症性改变或伴有血管炎性肉芽肿性的炎症性改变。由于间质性肺病是一种进展性的疾病,不论是早期还是晚期,一旦确诊都应立即进行治疗,方可阻止疾病发展。目前尚无任何药物治疗手段可以确切逆转或改变间质性肺病进程。在常规治疗方案中,常用的药物有糖皮质激素、免疫抑制剂、抗纤维化及抗氧化等药物,但这些药物的副作用有目共睹,且不适合终身使用。肺移植是目前唯一能够治愈间质性肺病的手段,但难以找到匹配的器官,术后器官排异问题也层出不穷。
由于间质性肺病既可是肺组织病变的一类单独疾病,又可是由多***疾病累及肺组织损伤的一类综合征,运用中医的整体观疗法应更适合。现代中医学者认为间质性肺病当归属于中医学的肺痹、肺痿、喘证等范畴。肺痿以气虚为根本病机,病性证素以痰、热最为多见,病位责之在肺、胃为主,可累及脾肾,分为寒热两类,阴虚内热、阳虚生寒是其内在机制,证候特点多以虚实夹杂为主。肺痹以实证为主,虚证则以肺肾气虚多见,亦可表现为虚实夹杂证,以气虚为本,气闭为标。临证当辨其虚实矛盾的主次而施治。截至目前,已有各大医家在临床实践中提出多种用于治疗或缓解间质性肺病的组方,组方用药各有长短。
CN104147517A公开了一种治疗特发性肺间质纤维化的中药组合物,包括太子参、南沙参、麦冬、玄参、黄芪、党参、苍术等16味药材,认为该组合物具有益气养阴、活血化瘀、开胸利气的作用。
CM109806349A公开了一种治疗肺间质纤维化的中药组合物,包括黄芪、党参、红参、白术、清半夏、茯苓、陈皮等27味药材,此外还可包括忍冬藤、白芍等6个成分,认为该组合物具有健脾补肺、化痰活血、止咳平喘的功效,可用于治疗肺间质纤维化。
然而,间质性肺病种类繁多、机制复杂,对间质性肺病机制与有效治疗的探索渐成为国内外研究热点。本申请的发明人通过研究,提出一种可用于间质性肺病的药物组合物,简化了组合物的组方,利于产品质量控制、降低生产成本,同时还能有效改善患者呼吸功能、提高患者生存质量,延缓病症进展,由此得到本申请。
发明内容
本申请提供了一种治疗间质性肺病的药物组合物及其制备方法。该组合物由黄芪10-15、生甘草10-15、地龙6-10、野菊花5-8和瓜蒌1-5组成。
该药物组合物中,各药材的用量为:黄芪12-15、生甘草12-15、地龙8-10、野菊花6-8和瓜蒌3-5。
优选的药物组合物是:黄芪15、生甘草15、地龙10、野菊花8和瓜蒌3。
本申请还提供了一种药物制剂,将上述药物组合物通过常规制药方法制得汤剂、颗粒剂、胶囊剂、片剂、滴丸等常规剂型产品。
本发明还提供了上述药物制剂的制备方法,包括:取黄芪、生甘草、野菊花和瓜蒌,加入10-15倍量蒸馏水,浸泡20-30分钟,煎煮至水量剩余一半时,倒出药液,再加入10-15倍量蒸馏水,煎煮至水量剩余一半,倒出药液,与之前药液混合,得汤剂。
本发明还提供了上述药物制剂的制备方法,包括:取黄芪、生甘草、野菊花和瓜蒌,加3-5倍量的50-80%乙醇回流提取1-3次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙,加3-5倍量0.9%氯化钠溶液提取1-2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3-5倍量水煎煮提取1-3次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为颗粒剂、胶囊剂、片剂等。
更具体地,该方法包括如下步骤:取黄芪、生甘草、野菊花和瓜蒌,加5倍量的75%乙醇回流提取2次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙,加5倍量0.9%氯化钠溶液提取2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3倍量水煎煮提取2次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为颗粒剂、胶囊剂、片剂等。
本申请的药物组合物仅由5味中药材组成,组方简单,利于产品质量控制以及生产成本的降低,同时还能止咳化痰,有效改善患者呼吸功能、提高患者生存质量,延缓病症进展,且无明显副作用。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将对本申请的技术方案作更进一步的详细说明。显然,本申请的保护范围不受具体实施例的任何限制,本领域普通技术人员在没有做出创造性劳动下所得到的所有其他实施例,都落入本申请的保护范围内。
间质性肺病患者的症状大多是进行性呼吸困难、干咳或有浓痰、胸痛等。其中进行性呼吸困难是最具有特征性的症状,最初发生于大量运动期间,随着病情进展,呼吸困难也可发生于静息期间,极大降低患者日常的生活质量。从肺功能角度,绝大多数间质性肺病患者均出现限制性通气障碍和弥散功能降低,表现为肺活量、肺总量、功能残气量和残气量减少,FEV1/FVC正常或偏高,一氧化碳弥散率和动脉血氧分压降低。
1.临床资料:选择间质性肺病患者68例,按照随机数字表法分为对照组和本发明药物组,每组各34例。对照组34例中男24例、女10例,年龄35-68岁,病程2m-2y;本发明药物组34例中男26例、女8例,年龄39-65岁,病程1m-3y。2组患者基线资料无统计学差异,可进行比较。
2.方法:对照组患者接受常规治疗,本发明药物组患者除接受常规治疗外还服用本发明实施例1的汤剂(一日两次,服药2周)。
观察指标:①观察2组患者治疗前后的肺功能变化;②观察2组患者治疗前后生活质量评分。采用SGRQ评分表进行,对日常生活、活动能力及症状的影响,总分为100分,总评分越低,表示生活质量越高。
统计学方法 计量资料采用t检验,P<0.05为差异具有统计学意义。
3.结果:
3.1肺功能检测
表1治疗前后2组患者的肺功能情况
注:t、P为2组组内比较检验值,t1、P1为2组治疗前比较检验值,t2、P2为2组治疗后比较检验值。
结果显示,治疗前2组患者肺功能无显著性差异(P>0.05);治疗后本发明药物组患者的肺功能显著优于对照组,差异有显著性(P<0.05)。
3.2 SGRQ评分
表2
结果显示,治疗前2组患者生活质量总评分比较无统计学差异(P>0.05);治疗后本发明药物组生活质量总评分均显著低于治疗前及对照组,显示生活质量得到极大改善,有统计学差异(P<0.05)。
4.小结
本申请药物组合物能很好地调动机体自身抗病能力,在改善间质性肺炎患者临床症状、提高生活质量等方面具有独到优势。对于目前尚无有效治疗方案的间质性患者来说,意义重大。
具体实施方式
实施例1
取黄芪15g、生甘草15g、地龙10g、野菊花8g和瓜蒌3g,加入10倍量蒸馏水,浸泡30分钟,煎煮至水量剩余一半时,倒出药液,再加入10倍量蒸馏水,煎煮至水量剩余一半,倒出药液,与之前药液混合,得汤剂。
实施例2
取黄芪1500g、生甘草1500g、野菊花800g和瓜蒌300g,加5倍量的75%乙醇回流提取2次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙1000g,加5倍量0.9%氯化钠溶液提取2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3倍量水煎煮提取2次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为颗粒剂。
实施例3
取黄芪1300g、生甘草1300g、野菊花800g和瓜蒌300g,加3倍量的80%乙醇回流提取3次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙900g,加5倍量0.9%氯化钠溶液提取2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3倍量水煎煮提取3次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为片剂。
Claims (8)
1.一种治疗间质性肺病的药物组合物,其特征在于由用量配比黄芪12-15、生甘草12-15、地龙8-10、野菊花6-8和瓜蒌3-5组成。
2.如权利要求1所述的药物组合物,其特征在于由用量配比黄芪15、生甘草15、地龙10、野菊花8和瓜蒌3组成。
3.一种药物制剂,其特征在于将权利要求1-2任一项所述的药物组合物通过常规制药方法制得汤剂、颗粒剂、胶囊剂、片剂。
4.如权利要求3所述的药物制剂的制备方法,其特征在于由如下方法制得:取黄芪、生甘草、地龙、野菊花和瓜蒌,加入10-15倍量蒸馏水,浸泡20-30分钟,煎煮至水量剩余一半时,倒出药液,再加入10-15倍量蒸馏水,煎煮至水量剩余一半,倒出药液,与之前药液混合,得汤剂。
5.如权利要求3所述的药物制剂的制备方法,其特征在于包括如下步骤:取黄芪、生甘草、野菊花和瓜蒌,加3-5倍量的50-80%乙醇回流提取1-3次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙,加3-5倍量0.9%氯化钠溶液提取1-2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3-5倍量水煎煮提取1-3次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为颗粒剂、胶囊剂、片剂。
6.如权利要求5所述的制备方法,其特征在于包括如下步骤:
取黄芪、生甘草、野菊花和瓜蒌,加5倍量的75%乙醇回流提取2次,每次2小时,滤过,滤液合并,得滤液1,药渣待用;另取地龙,加5倍量0.9%氯化钠溶液提取2次,每次2小时,滤过,滤液合并,得滤液2,药渣待用;取前述所得的全部药渣,合并后用3倍量水煎煮提取2次,提取液过滤,得滤液3;合并滤液1-3,减压浓缩至相对密度为1.15-1.25的稠膏,进一步减压干燥,得到干膏,按照常规方法将干膏制备为颗粒剂、胶囊剂、片剂。
7.如权利要求1-2任一项所述的药物组合物或权利要求3所述的药物制剂在制备治疗间质性肺病的药物中的用途。
8.如权利要求4-6任一项所述的方法制得的药物制剂在制备治疗间质性肺病的药物中的用途。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010557283.5A CN111494454B (zh) | 2020-06-16 | 2020-06-16 | 一种治疗间质性肺病的药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010557283.5A CN111494454B (zh) | 2020-06-16 | 2020-06-16 | 一种治疗间质性肺病的药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111494454A CN111494454A (zh) | 2020-08-07 |
CN111494454B true CN111494454B (zh) | 2022-06-24 |
Family
ID=71878777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010557283.5A Active CN111494454B (zh) | 2020-06-16 | 2020-06-16 | 一种治疗间质性肺病的药物组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111494454B (zh) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101991832B (zh) * | 2010-10-30 | 2012-09-26 | 支开叶 | 一种治疗特发性肺纤维化的药物及其制备方法 |
CN108324833B (zh) * | 2018-04-28 | 2021-02-05 | 山东中医药大学附属医院 | 一种治疗***病相关性间质性肺病的中药制剂 |
-
2020
- 2020-06-16 CN CN202010557283.5A patent/CN111494454B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN111494454A (zh) | 2020-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102258688B (zh) | 一种治疗慢性阻塞性肺疾病肺脾气虚证的中药 | |
CN103520572B (zh) | 一种用于治疗特应性皮炎的中药组合物及其制备方法 | |
CN103301356A (zh) | 一种慢性肾衰竭用灌肠液制备方法 | |
CN105497811A (zh) | 一种治疗肝硬化的中药组合物及其制备工艺 | |
CN111494454B (zh) | 一种治疗间质性肺病的药物组合物 | |
CN104042956A (zh) | 一种治疗糖尿病的药物及其制备方法 | |
CN103393938B (zh) | 一种降血糖的中药组合物 | |
CN105902897A (zh) | 一种治疗胰腺癌的药物制剂及其用途 | |
CN105106710A (zh) | 医治哮喘的润肺化痰制剂的制备方法 | |
CN105194355A (zh) | 一种治疗原发性高血压的中药制剂 | |
CN112138105B (zh) | 一种治疗支气管扩张症肺脾气虚、痰湿阻肺证的中药组合物及其应用 | |
CN117244015B (zh) | 一种治疗肺部结节的中药组合物及其应用 | |
CN104189615B (zh) | 一种治疗崩漏的中药制剂及其制备方法 | |
CN103341095A (zh) | 一种慢性肾衰竭用灌肠液 | |
CN116440224B (zh) | 一种中药组合物、制剂及制备方法 | |
CN102805795B (zh) | 一种治疗急性胸胁部软组织损伤的中药组合物及其应用 | |
CN103330861B (zh) | 一种治疗霍乱的药物及其制备方法 | |
CN103316270B (zh) | 一种治疗产后***粘膜病变药物的散剂制备方法 | |
CN102716347B (zh) | 一种治疗高血压病的藏药及其制备方法 | |
CN102085244B (zh) | 一种用于治疗消化***疾病的中成药 | |
CN104771673A (zh) | 一种治疗慢性支气管炎的中药 | |
CN105943860A (zh) | 一种用于治疗糖尿病的药物制剂及其制备方法 | |
CN113876881A (zh) | 一种改善睡眠的中药组合物及其制备方法 | |
CN104784487A (zh) | 一种用于治疗肺栓塞的中药制剂及制备方法 | |
CN104147199B (zh) | 一种用于治疗***的中药 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 801, Zhuzong real estate building, A2 Huixin East Street, Chaoyang District, Beijing 100029 Patentee after: Beijing Dongfang Yunjia Pharmaceutical Co.,Ltd. Address before: 801, Zhuzong real estate building, A2 Huixin East Street, Chaoyang District, Beijing 100029 Patentee before: BEIJING ORIENTAL FORTUNE TECHNOLOGY DEVELOPMENT Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder |