CN111481178A - Quantitative superficial sensation comprehensive analysis early warning system and method and application - Google Patents

Quantitative superficial sensation comprehensive analysis early warning system and method and application Download PDF

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CN111481178A
CN111481178A CN202010321825.9A CN202010321825A CN111481178A CN 111481178 A CN111481178 A CN 111481178A CN 202010321825 A CN202010321825 A CN 202010321825A CN 111481178 A CN111481178 A CN 111481178A
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temperature
infrared
microprocessor
silicon lens
probe
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CN111481178B (en
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李子超
胡大海
窦伟滔
苏琳琳
易晓巍
周琴
朱婵
程静
石雪芹
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Air Force Medical University of PLA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4824Touch or pain perception evaluation
    • A61B5/4827Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
    • A61B5/483Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold by thermal stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B50/00Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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Abstract

The invention relates to a quantitative superficial sensation comprehensive analysis early warning system and a method and application thereof, wherein the system comprises a probe, the probe comprises an upper cover, a cold-heat exchange device, a probe shell and an infrared silicon lens, one end of the cold-heat exchange device is sleeved with the probe shell, the other end of the cold-heat exchange device is sleeved with the upper cover, and the infrared silicon lens is arranged on the end surface of the probe shell; the cold-heat exchange device is a cylindrical heat dissipation shell with a heat dissipation fin at one end, a contact head arranged along the axis direction of the cylinder is arranged in the cylindrical heat dissipation shell, an infrared temperature sensor and a microprocessor are arranged at one end of the contact head, and a pressure sensor is arranged at the other end of the contact head; a temperature detection device is arranged in the probe shell and is tightly attached to the infrared silicon lens, and the infrared silicon lens is also connected with the temperature changing device and the pressure sensor through a heat conduction spring and a force conduction spring respectively. The invention can carry out quantitative analysis on the abnormal conditions of the superficial sensation of the periphery of the body, effectively protect the safety and detect the specific conditions, and can be used as auxiliary medical equipment in the cold therapy and heat therapy process.

Description

Quantitative superficial sensation comprehensive analysis early warning system and method and application
Technical Field
The invention relates to a system for measuring peripheral sensation, in particular to a quantitative superficial sensation comprehensive analysis early warning system and method and application. Belongs to the field of medical appliances.
Background
With the clinical needs and urgent needs of scientific research in departments of orthopedics, burn surgery, neurology and the like, the development of a quantitative analysis system for superficial sensory functions of a subject is particularly important. Although temperature sensation analyzers which are internationally put into use in the medical and scientific research fields can measure (cold, hot, cold pain and hot pain) threshold values to a certain extent, time errors may exist between protective reactions (such as hand contraction and foot contraction) and mouse click confirmation when the pain threshold values are reached due to the fact that the mouse is clicked by a hand to record the temperature, and therefore quantification is not accurate and only the temperature of a probe when the mouse is clicked can be recorded instead of the accumulated temperature of the actual skin. In addition, can arouse scald or frostbite when skin accumulative temperature surpasss safe temperature, to the unusual crowd of periphery sensation, especially the crowd of dysesthesia or disappearance (like congenital spina bifida), more need one can quantitative analysis and can play the test system of monitoring the early warning, come to protect and the early warning to crowd's skin safety through reporting to the police, carry out the heat-sinking capability of comprehensive judgement skin to better can play the effect of appraisal and auxiliary treatment to the patient. Finally, previous quantitative analysis systems of superficial sensory function cannot archive historical test data of the skin to reflect actual course changes of the skin.
Disclosure of Invention
The purpose of the invention is: in order to overcome the problems in the prior art, a quantitative superficial sensation comprehensive analysis early warning system and method are provided, and one of the purposes is as follows: the skin accumulated temperature can be monitored in real time; the second purpose is that: can measure and judge the index of the skin self-protective ability, such as measuring the thermal pain threshold when receiving self-constant temperature heating or the skin accumulated temperature when generating self-protective reaction (hand-contracting reaction); the third purpose is: the skin temperature of the skin at a specific position can be measured, and the skin temperature measuring instrument can be used as auxiliary medical equipment in the cold therapy and heat therapy processes to realize the skin safety protection of special people; the fourth purpose is: the system can carry out quantitative analysis and effective safety protection on the abnormal conditions of the self-body peripheral superficial sensation (pain and temperature sensation); the fifth purpose is: through setting up the support, can liberate both hands when the survey, make the doctor concentrate on the collection of survey index in full heart, increase system ground stability, avoid the operation to bring pressure sensor's change. The sixth purpose is: provides an application of a quantitative superficial sensation comprehensive analysis early warning system.
The technical scheme adopted by the invention is as follows: the quantitative superficial sensation comprehensive analysis early warning system comprises a probe, wherein the probe comprises an upper cover, a heat exchange device, a probe shell and an infrared silicon lens, one end of the heat exchange device is sleeved with the probe shell, the other end of the heat exchange device is sleeved with the upper cover, and the infrared silicon lens is arranged on the end face of the probe shell; the cold-heat exchange device is a cylindrical heat dissipation shell with a heat dissipation fin at one end, a contact head arranged along the axis direction of the cylinder is arranged in the cylindrical heat dissipation shell, an infrared temperature sensor and a microprocessor are arranged at one end of the contact head, and a pressure sensor is arranged at the other end of the contact head; the probe shell is cylindrical, a temperature detection device is arranged in the probe shell, the temperature detection device is annular and is tightly attached to the infrared silicon lens, and the infrared silicon lens is also connected with the temperature changing device and the pressure sensor through a heat conduction spring and a force conduction spring respectively; the temperature changing device and the contact head are positioned on the same axis correspondingly, the temperature changing device and the cold-heat exchange device form an environment generating unit, the environment generating unit is electrically connected with the microprocessor through a temperature control relay, and the infrared temperature sensor, the pressure sensor and the temperature detecting device are respectively electrically connected with the microprocessor.
Furthermore, the quantitative superficial sensation comprehensive analysis and early warning system further comprises a direct current power supply and a PC (personal computer) which are arranged outside the probe, wherein an external wiring hole is formed in the end face of the upper cover, the direct current power supply supplies power to the environment generation unit and the microprocessor through the external wiring hole, and the microprocessor is in electric signal connection with the PC.
Furthermore, the contact head is cylindrical, an inner wiring hole is formed in the outer wall of the cylinder, and the pressure sensor and the temperature detection device are electrically connected with the microprocessor through the inner wiring hole respectively.
Furthermore, the temperature changing device is a semiconductor refrigeration piece, the semiconductor refrigeration piece and the pressure sensor are both of annular structures, the pressure sensor is sleeved on the contact head, a plurality of force guide springs are uniformly distributed on the outer side of the contact head along the axial direction of the contact head, one end of each force guide spring is fixedly connected with the pressure sensor, the other end of each force guide spring is tightly attached to the infrared silicon lens, one or more heat guide springs are arranged, one end of each heat guide spring is fixed on the semiconductor refrigeration piece, and the other end of each heat guide spring is tightly attached to the infrared silicon lens and is positioned on the inner side of the corresponding force guide spring; the temperature detection device is an annular thermistor, the diameter of the annular thermistor is larger than that of the pressure sensor, the diameter of the semiconductor refrigeration piece is the same as that of the contact head, and the annular thermistor, the semiconductor refrigeration piece, the pressure sensor and the contact head are coaxial.
Furthermore, a bracket fixing hole is formed in the side wall of the upper cover; and the support fixing hole is internally provided with threads.
Further, the support fixed orifices have the support through threaded connection, the support comprises support seat and support aluminium core stay tube, support aluminium core stay tube one end is fixed on the support seat, the other end passes through the screw thread and can dismantle with the support fixed orifices and be connected.
Furthermore, the probe is made of a titanium alloy material; the infrared silicon lens has more than 90 percent of transmittance to infrared lightExcessive rate and heat conductivity coefficient of 150
Figure 100002_DEST_PATH_IMAGE002
(ii) a The heat-conducting spring is made of copper material and has heat conductivity of 410
Figure 100002_DEST_PATH_IMAGE002A
(ii) a The elastic coefficient of the force guide spring
Figure 100002_DEST_PATH_IMAGE004
Is 0.4
Figure 100002_DEST_PATH_IMAGE006
The relationship between the displacement of the spring and the pressure is
Figure 100002_DEST_PATH_IMAGE008
Wherein
Figure 100002_DEST_PATH_IMAGE010
In order to act on the pressure sensor in a pressure-sensitive manner,
Figure 100002_DEST_PATH_IMAGE004A
is the elastic coefficient of the spring and is,
Figure 100002_DEST_PATH_IMAGE012
is the amount of displacement of the spring.
Further, the speed of the temperature rise and the temperature fall of the infrared silicon lens is 1 ℃/s; the temperature changing device is a semiconductor refrigerating piece, and the temperature changing device, the pressure sensor and the heat and cold exchanging device are all of hollow structures and provide a light path between the infrared silicon lens and the infrared temperature sensor.
Further, a quantitative superficial sensation comprehensive analysis and early warning method comprises the following specific steps:
(1) setting the probe into a temperature changing mode through a PC, setting the test initial temperature to be 30-32 ℃, and then transmitting the test initial temperature to a microprocessor;
(2) after the microprocessor receives the temperature change instruction, the microprocessor changes the temperature of the contact surface of the temperature change device and the heat conduction spring through the temperature control relay, and then the temperature is conducted to the infrared silicon lens through the heat conduction spring, so that the temperature change of the infrared silicon lens is realized within-5-50 ℃; the temperature of the infrared silicon lens is monitored in real time through a temperature detection device, and the monitored temperature is transmitted to the microprocessor;
(3) setting the upper limit and the lower limit of the safe temperature to 44 ℃ and 10.8 ℃ through a PC (personal computer), detecting a detected object through an infrared silicon lens of a probe, detecting the temperature of the detected object through the infrared silicon lens by using an infrared temperature sensor 1, and transmitting the detected temperature to a microprocessor; the microprocessor transmits the data detected by the temperature detection device and the infrared temperature sensor to the PC for data storage, data analysis and filing;
(4) when the temperature of the measured object reaches a threshold value, an acousto-optic alarm device in the PC sends out early warning to remind the user of paying attention, and the duration is 30 s; when the infrared temperature sensor detects that the accumulated temperature of the measured object exceeds the warning temperature for more than 30s, the microprocessor sends out an alarm signal and automatically changes the voltage at two ends of the temperature changing device to carry out a cold and heat source rewarming mode, so that the temperature of the measured object returns to a safe temperature range of 30-32 ℃;
(5) if the infrared silicon lens moves, the pressure signal is transmitted to the pressure sensor through the force guide spring, the pressure sensor transmits the movement information of the detected infrared silicon lens to the microprocessor, and the data detected by the microprocessor is transmitted to the PC for data storage, data analysis and filing.
Furthermore, the quantitative superficial sensation comprehensive analysis early warning system is used as a heat source or a cold source and becomes auxiliary medical equipment for carrying out thermal therapy or cold therapy; or as an instrument for measuring nerve conduction; or an instrument for the accurate determination of the melting point of a substance; or an apparatus for the thermodynamic identification of the purity of a substance: or an instrument for quality control of temperature-sensitive substances and thermolabile materials.
The invention has the advantages that: the system of the invention can carry out quantitative analysis and effective safety protection on the abnormal conditions of the self-body peripheral superficial sensation (pain and temperature sensation), detect the specific conditions related to the skin and assist medical equipment in the cold therapy and heat therapy process; the specific functions are as follows: 1) the temperature changing and constant temperature control can be realized by utilizing the temperature changing device, the heat conducting spring, the infrared silicon lens, the temperature detection device and the infrared sensor, the function of measuring (cold, hot, cold pain and hot pain) threshold values in the probe temperature changing mode is realized, the precision and the application range of the quantitatively measured (cold, hot, cold pain and hot pain) threshold values are improved, the accumulated temperature of the skin is monitored in real time, the early warning for setting the upper limit and the lower limit of the safe temperature of the skin is established through the microprocessor and the PC, the skin is timely reheated after the early warning, and the secondary damage of the skin caused by the detection process is prevented; )
2) The index for judging the self-protective ability of the skin can be obtained quantitatively through the force-conducting spring and the pressure sensor, and the accumulated temperature of the skin when the skin is heated by a constant-temperature heating source (a milder heat source can not generate obvious protective reaction when contacting the skin), a thermal pain threshold value or the protective reaction (similar hand shortening reaction) is generated is measured.
3) The temperature change of the temperature changing device can be used for auxiliary medical equipment in the cold therapy and heat therapy processes, and the skin safety protection of people with peripheral shallow feeling reduction, dullness or disappearance is realized. Meanwhile, the system can also be used for measuring nerve conduction, the accurate determination of the melting point of a substance and the like, and provides a wide application prospect for probe testing.
4) Utilize the support, liberate both hands during the survey, can let the doctor concentrate on the collection of survey index with one's mind. The stability of the system is improved, the change of the pressure sensor caused by operation is avoided, and the accuracy of test data is improved.
5) The PC can be used for filing, so that the disease course change of the patient can be conveniently analyzed and counted, and the disease condition of the patient can be reasonably decided. Meanwhile, the initial temperature of the skin is obtained quantitatively by combining a ninth method, and the heat dissipation capacity of the skin or peripheral nerve and blood vessel diseases are comprehensively judged.
Drawings
The invention is further illustrated but not limited by the following figures and examples.
FIG. 1 is a schematic diagram of the present invention;
FIG. 2 is a block diagram of the invention after it is integrally installed;
fig. 3 is a schematic diagram of a specific structure of the present invention.
In the figure, 1, an infrared temperature sensor; 2. a pressure sensor; 3. an environment generation unit; 4. a temperature changing device; 5. a heat exchange device; 5-1, radiating fins; 5-2, a cylindrical heat dissipation shell; 5-3, internal wiring holes; 5-4, contact head; 6. a temperature control relay; 7. a temperature detection device; 8. a direct current power supply; 9. a microprocessor; 10. PC; 11. an infrared silicon lens; 12. a probe housing; 13; a heat conductive spring; 14. a force-conducting spring; 15. an external wiring hole; 16. a bracket fixing hole; 17. and (7) covering.
Detailed Description
Example 1
As shown in fig. 1, fig. 2 and fig. 3, the quantitative superficial sensation comprehensive analysis and early warning system comprises a probe, wherein the probe comprises an upper cover 17, a heat exchanger 5, a probe shell 12 and an infrared silicon lens 11, one end of the heat exchanger 5 is sleeved with the probe shell 12, the other end of the heat exchanger is sleeved with the upper cover 17, and the infrared silicon lens 11 is arranged on the end surface of the probe shell 12; the cold-heat exchange device 5 is a cylindrical heat dissipation shell 5-2 with a heat dissipation fin 5-1 at one end, a contact 5-4 arranged along the axial direction of the cylinder is arranged in the cylindrical heat dissipation shell 5-2, one end of the contact 5-4 is provided with an infrared temperature sensor 1 and a microprocessor 9, and the other end is provided with a pressure sensor 2; the probe shell 12 is cylindrical, a temperature detection device 7 is arranged in the probe shell, the temperature detection device 7 is annular and is tightly attached to the infrared silicon lens 11, and the infrared silicon lens 11 is also connected with the temperature changing device 4 and the pressure sensor 2 through a heat conduction spring 13 and a force conduction spring 14 respectively; the temperature changing device 4 corresponds to the contact heads 5-4 on the same axis, the temperature changing device 4 and the cold-heat exchange device form an environment generating unit 3, the environment generating unit 3 is electrically connected with a microprocessor 9 through a temperature control relay 6, and the infrared temperature sensor 1, the pressure sensor 2 and the temperature detection device 7 are respectively electrically connected with the microprocessor 9.
When the system works, the infrared sensor detects the temperature of a measured object outside the infrared silicon lens 11 through the infrared silicon lens 11, measures the temperature of the infrared silicon lens in real time through the temperature detection device, and can adjust the temperature of the infrared silicon lens through the temperature changing device; because the infrared temperature sensor and the microprocessor are arranged in the cavity of the radiator, the infrared silicon lens has high transmittance to infrared light, so that the temperature change of the infrared silicon lens has little influence on the infrared temperature sensor. The microprocessor collects data of the thermistor, the pressure sensor and the infrared temperature sensor to make processing judgment. Meanwhile, the heat exchange device 5 provides a stable temperature environment for the microprocessor.
Example 2
On the basis of embodiment 1, as shown in fig. 1, the quantitative temperature comprehensive analysis and early warning system further includes a dc power supply 8 and a PC10 which are arranged outside the probe, an external wiring hole 15 is arranged on an end surface of the upper cover 17, the dc power supply 8 supplies power to the environment generating unit 3 and the microprocessor 9 through the external wiring hole 15, and the microprocessor 9 is in electrical signal connection with the PC 10.
Preferably, the microprocessor is of a model STM32F103RCT6, and a signal acquisition ADC module and the like are integrated therein, which belongs to the prior art and will not be described in detail herein.
As shown in fig. 3, the contact head 5-4 is cylindrical, an inner wiring hole is arranged on the outer wall of the cylinder, and the pressure sensor 2 and the temperature detection device 7 are respectively and electrically connected with the microprocessor 9 through the inner wiring hole.
Further, the temperature changing device 4 is a semiconductor refrigeration sheet, the semiconductor refrigeration sheet and the pressure sensor 2 are both of an annular structure, the pressure sensor 2 is sleeved on the contact heads 5-4, the plurality of force guide springs 14 are uniformly distributed on the outer sides of the contact heads 5-4 along the axial direction of the contact heads 5-4, one end of each force guide spring 14 is fixedly connected with the pressure sensor 2, the other end of each force guide spring is tightly attached to the infrared silicon lens, one or more heat guide springs 13 are provided, one end of each heat guide spring is fixed on the semiconductor refrigeration sheet, the other end of each heat guide spring is tightly attached to the infrared silicon lens, and the heat guide springs are positioned on the inner side of the force guide spring 14; the temperature detection device 7 is an annular thermistor, the diameter of the annular thermistor is larger than that of the pressure sensor 2, the diameter of the semiconductor refrigeration piece is the same as that of the contact 5-4, and the annular thermistor, the semiconductor refrigeration piece, the pressure sensor 2 and the contact 5-4 are coaxial.
The temperature of the infrared silicon lens is changed by combining the heat-conducting spring and the semiconductor refrigerating sheet. One end of the heat conduction spring is tightly attached to one end face of the semiconductor refrigeration sheet, the other end of the heat conduction spring is tightly attached to the infrared silicon lens to play a role in heat conduction, and the infrared silicon lens can compress the heat conduction spring to move in a certain range when being subjected to external force, so that the other side of the semiconductor refrigeration sheet is attached to the radiator, and the temperature is kept near the room temperature all the time; when the semiconductor refrigerating sheet is applied with forward voltage, the contact surface of the semiconductor refrigerating sheet and the heat-conducting spring refrigerates, and the other surface of the semiconductor refrigerating sheet heats; when reverse voltage is applied, the contact surface of the semiconductor refrigerating sheet and the heat conducting spring is heated, and the other surface of the semiconductor refrigerating sheet is refrigerated.
The invention senses the movement of the infrared silicon lens by combining the pressure sensor and the force guide spring set. When the infrared silicon lens is displaced under the action of external force, the force-guiding spring is pressed to deform to generate pressure and act on the pressure sensor. The pressure sensor 2 will detect the infrared silicon lens 11, and since one end of the pressure sensor is fixed on the contact head of the heat exchanger 5, the pressure sensor will not displace when under pressure.
Further, the PC10 is a computer or a PID controller and is provided with an audible and visual alarm device. Audible and visual alarm devices are well known to those skilled in the art and will not be described in detail herein.
Further, the speed of the temperature rise and the speed of the temperature fall of the infrared silicon lens 1 are 1 ℃/s; the temperature changing device 4 is a semiconductor refrigerating sheet, the temperature changing device 4, the pressure sensor 2 and the heat and cold exchanging device 5 are all of hollow structures, and a light path is provided between the infrared silicon lens 11 and the infrared temperature sensor 1, so that the infrared temperature sensor 1 can accurately measure conveniently.
A method for quantitative temperature comprehensive analysis and early warning comprises the following specific steps:
(1) the probe is set into a temperature changing mode through the PC10, the initial test temperature is set to be 30-32 ℃, and then the temperature is transmitted to the microprocessor 9;
(2) after the microprocessor 9 receives the temperature change instruction, the microprocessor 9 changes the temperature of the contact surface of the temperature change device 4 and the heat conduction spring 13 through the temperature control relay 6, and then the temperature is conducted to the infrared silicon lens 11 through the heat conduction spring 13, so that the temperature change of the infrared silicon lens 11 is realized within-5 ℃ to 50 ℃; the temperature of the infrared silicon lens 1 is monitored in real time through the temperature detection device 7, and the monitored temperature is transmitted to the microprocessor 9;
(3) the upper limit and the lower limit of the safe temperature are set to 44 ℃ and 10.8 ℃ through PC10, the detected object is detected through an infrared silicon lens of the probe, the infrared temperature sensor 1 detects the temperature of the detected object through an infrared silicon lens 11, and the detected temperature is transmitted to a microprocessor 9; the microprocessor 9 transmits the data detected by the temperature detection device 7 and the infrared temperature sensor 1 to the PC10 for data storage, data analysis and filing;
(4) when the temperature of the measured object reaches a threshold value, an audible and visual alarm device in the PC10 gives out early warning to remind the user of paying attention for 30 s; when the infrared temperature sensor 1 detects that the accumulated temperature of the measured object exceeds the warning temperature for more than 30s, the microprocessor 9 sends out an alarm signal and automatically changes the voltage at two ends of the temperature changing device 4 to carry out a cold and heat source rewarming mode, so that the temperature of the measured object returns to a safe temperature range of 30-32 ℃;
(5) if the infrared silicon lens 1 moves, the pressure signal is transmitted to the pressure sensor 2 through the force guide spring 14, the pressure sensor 2 transmits the detected movement information of the infrared silicon lens 11 to the microprocessor 9, and the data detected by the microprocessor 9 is transmitted to the PC10 for data storage, data analysis and filing.
Example 3
On the basis of embodiment 1 or 2, a bracket fixing hole 16 is arranged on the side wall of the upper cover 17; the support fixing hole 16 is internally provided with threads. The support fixing hole 16 is connected with a support through threads, the support is composed of a support base and a support aluminum core supporting tube, one end of the support aluminum core supporting tube is fixed on the support base, and the other end of the support aluminum core supporting tube is detachably connected with the support fixing hole 16 through threads.
When the device is used, the support aluminum core supporting tube is connected with the probe through threads of the support fixing hole, and the probe is positioned at a proper position for detection by adjusting the height, the left position and the right position of the support aluminum core supporting tube. The invention utilizes the bracket, frees both hands during the determination, and can lead a doctor to concentrate on the acquisition of the determination index. The stability of the system is improved, the change of the pressure sensor caused by operation is avoided, and the accuracy of test data is improved.
Example 4
On the basis of embodiment 3, the material of the probe is a titanium alloy material; the infrared silicon lens (11) has a transmittance of more than 90% for infrared light and a heat conductivity coefficient of 150
Figure DEST_PATH_IMAGE002AA
(ii) a The test accuracy of the infrared sensor is guaranteed. The heat-conducting spring is made of copper material and has heat conductivity of 410
Figure DEST_PATH_IMAGE002AAA
(ii) a The elastic coefficient of the force guide spring
Figure DEST_PATH_IMAGE004AA
Is 0.4
Figure DEST_PATH_IMAGE006A
The relationship between the displacement of the spring and the pressure is
Figure DEST_PATH_IMAGE008A
Wherein
Figure DEST_PATH_IMAGE010A
In order to act on the pressure sensor in a pressure-sensitive manner,
Figure DEST_PATH_IMAGE004AAA
is the elastic coefficient of the spring and is,
Figure DEST_PATH_IMAGE012A
is the amount of displacement of the spring.
Example 5
The invention discloses an application of a quantitative superficial sensation comprehensive analysis early warning system, which comprises the following steps: the subject in this embodiment may be skin, or other object.
Firstly, the test of the skin is specifically explained:
1. the specific testing steps are as follows:
(1) the probe was set to the temperature varying mode by the PC10 and the test initial temperature was set to 30-32 ℃ (no cold or heat was felt by contact for several seconds in this temperature) and then transmitted to the microprocessor 9;
(2) after the microprocessor 9 receives the temperature change instruction, the microprocessor 9 changes the temperature of the contact surface of the temperature change device 4 (semiconductor refrigeration sheet) and the heat conduction spring 13 through the temperature control relay 6, and then the temperature is conducted to the infrared silicon lens 11 through the heat conduction spring 13, so that the temperature change of the infrared silicon lens 11 is realized within-5-50 ℃; the temperature of the infrared silicon lens 1 is monitored in real time through a temperature detection device 7 (a thermistor), and the monitored temperature is transmitted to a microprocessor 9;
(3) the upper limit and the lower limit of the safe skin temperature are set to 44 ℃ and 10.8 ℃ through PC10, the skin is detected through an infrared silicon lens of a probe, and an infrared temperature sensor 1 detects the skin temperature through an infrared silicon lens 11 and transmits the detected temperature to a microprocessor 9; the microprocessor 9 transmits the data detected by the temperature detection device 7 and the infrared temperature sensor 1 to the PC10 for data storage, data analysis and filing;
(4) when the skin temperature reaches a threshold value, an acousto-optic alarm device in the PC10 sends out early warning to remind the user of paying attention for 30 s; when the infrared temperature sensor 1 detects that the accumulated temperature of the measured object exceeds the warning temperature for more than 30s, the microprocessor 9 sends out an alarm signal and automatically changes the voltage at the two ends of the temperature changing device 4 to carry out a cold and heat source rewarming mode, so that the skin temperature returns to a safer temperature range of 30-32 ℃; the speed of the temperature rise and the speed of the temperature fall of the infrared silicon lens are 1 ℃/s;
the sequence is that firstly the cold threshold is measured by the infrared temperature sensor, then the cold pain threshold is measured, after 5 minutes, the initial temperature of the monitored skin is the same as that before monitoring, the measurement of the hot threshold and the hot pain threshold is carried out (considering that the peripheral sensation is not sensitive to the cold stimulus, the use of the process can reduce the sensitivity to the cold sensation after the thermal stimulus is carried out to the maximum extent, in addition, the influence of the cold perception state on the hot perception state is avoided at proper time intervals, thereby improving the measurement precision)
(5) When the invention is used, the invention is controlled by a dual control system (namely, automatic control by components such as a sensor, a microprocessor and the like and manual control by a mouse), when the threshold values of cold, heat, cold pain and hot pain are measured, a patient clicks a button by using the mouse, and the accumulated skin temperature, the heat source temperature and the heating (refrigerating) time when the button is clicked are recorded. On the other hand, the pressure sensor attached to the probe can identify protective reactions (such as hand contraction reaction, at the moment, the pressure sensor can detect the movement of the infrared silicon lens) caused by cold pain and hot pain, and carries out signal conversion through the sensor and the microprocessor to record the accumulated temperature of the skin, the temperature of a heat source and the heating (refrigerating) time. The method greatly improves the accuracy of the threshold value of quantitative measurement (cold, hot, cold and hot pain) and the application range of people. When recording, the recording time is selected from the time before.
The invention quantitatively obtains an index capable of judging the self-protective capability of the skin, and determines the cumulative temperature and time of the skin when the skin is heated by a constant-temperature heating source (a milder heat source can not generate obvious protective reaction when contacting the skin), a thermal pain threshold value or the self-protective reaction (similar hand shortening reaction, at the moment, a pressure sensor can detect the movement of an infrared silicon lens) based on the hot plate experiment principle. The skin accumulated temperature is monitored in real time through the infrared temperature sensor, an early warning system with set upper limit and lower limit of skin safety temperature is established, and secondary damage to the skin caused by the detection process is prevented.
2. When the invention is tested, the initial temperature of the skin can be obtained quantitatively by combining the ninth method, the heat dissipation capability of the skin or peripheral nerve and blood vessel diseases can be judged comprehensively, and the method comprises the following specific steps:
1) equally dividing the detected skin part into 9 areas, measuring the skin temperature of the skin of a target area, recording the temperature of each area by using a PC (personal computer), repeatedly measuring each area, automatically carrying out rank sum test by using a microprocessor according to 9 numerical values measured by the two areas, and judging whether the skin temperature is normal or not;
2) measuring the skin temperature of the skin of the corresponding healthy area on the healthy skin on the opposite side or around the detected skin part in the same way, and recording the temperature of each area by using a PC (personal computer), wherein each area can be repeatedly measured;
the two steps are completed, the PC automatically performs rank sum check on the 9 values measured in the two areas recorded in the two steps, and if the two values have statistical difference, the PC performs comprehensive judgment by combining other clinical indexes;
if the local skin temperature is higher, the skin may have the pathological changes of hypofunction of heat dissipation (hypofunction of sweat glands) or local skin inflammation and the like; if the local skin temperature is low, it is suspected to be related to peripheral vascular disease and peripheral nerve dysfunction.
And the progress of the disease or the effectiveness of the treatment is analyzed synthetically by recording at different times and keeping a record of the skin temperature.
3. After the microprocessor of the present invention transmits the data to the PC, the PC saves the data, forms an archive for individual patients and can combine L OESS model, analyze the course of disease change of the patient, and automatically combine the obtained data with rank test (rank sum test and kruscal willis test) to perform statistical test.
The system of the invention can obtain the accumulated skin temperature when various thresholds are generated on the basis of improving the accuracy of the measured threshold (cold, hot, cold pain and hot pain). In addition, the temperature probe can be adjusted to be constant at 47 +/-3 ℃ and 0 +/-3 ℃, the time required for protective reaction or thermal pain and the accumulated temperature of the skin are measured, the index capable of judging the self-protective performance of the skin is obtained quantitatively, and the comprehensive analysis can be carried out by combining the measured (cold, heat, cold pain and thermal pain) threshold value result through the index, so that whether the self-peripheral superficial sensation (pain and temperature sensation) is abnormal or not and the abnormal weight are judged and identified quantitatively. In addition, due to the real-time temperature detection early warning system and the intelligent rewarming system, skin damage to a subject caused by detection can be avoided. The determined crowd with peripheral superficial paresthesia can set the skin safety temperature in advance when some heat treatment or cold treatment (such as hip bath) is carried out, and monitor the skin accumulated temperature in real time, and can protect and early warn the skin safety of the crowd by alarming when reaching the safety threshold. The infrared silicon lens and the infrared temperature sensor can quantitatively measure the skin temperature of the skin at a specific position, and can comprehensively judge the heat dissipation capacity of the skin by combining with sweat gland function detection. Therefore, the system plays an important role in diagnosis, identification, adjuvant therapy and long-term monitoring of diseases.
Secondly, the quantitative superficial sensation comprehensive analysis early warning system is used as a heat source or a cold source and becomes auxiliary medical equipment for thermal therapy or cold therapy: the probe is set to be in a constant temperature mode through the PC, and the microprocessor controls the voltage applied to two ends of the semiconductor refrigeration piece after receiving the instruction to control the temperature of the temperature changing device, so that the temperature of the infrared silicon lens is fixed at 47 +/-3 ℃ or 0 +/-3 ℃ and is used as a heat source or a cold source; can be used as auxiliary medical equipment in the thermal therapy or cold therapy process to realize the skin safety protection of people with peripheral superficial feeling hypoesthesia, dullness or disappearance.
1) When the population is treated by heat therapy or cold therapy, the probe is fixed above the skin to detect the patient;
2) the upper limit of the safe skin temperature is set to be 44 ℃ and the lower limit is set to be 10.8 ℃, so that the thermal therapy or the cold therapy is adopted, the early warning is carried out when the accumulated skin temperature exceeds the set warning temperature, the mode of rewarming is automatically changed when the duration time is more than 30s, and the skin temperature damage caused by the therapy is prevented.
If the skin temperature is normal, the probe temperature is fixed at 47 +/-3 ℃, and the time and the skin accumulated temperature for the skin to generate the thermal pain and the protective reaction are recorded. When the skin accumulated temperature exceeds the set warning temperature, early warning is carried out, the mode is automatically changed into the rewarming mode when the duration time is more than 30s, and skin temperature damage caused by treatment is prevented.
The quantitative superficial sensory comprehensive analysis early warning system is used as an instrument for measuring nerve conduction: the nerve conduction of animals can be measured in animal experiments, and the animal does not have the autonomous consciousness to record thermal pain, cold pain and the like passing through the system, so that the pressure sensor records multiple indexes of time of protective reaction (foot contraction reaction), heat source temperature and skin accumulated temperature, and the peripheral nerve conduction condition of the animal is quantitatively analyzed.
The quantitative superficial sensation comprehensive analysis early warning system is used as an instrument for accurately measuring the melting point of a substance: the precise determination of the melting point of the substance is specifically as follows: 1) the function is based on the temperature changing mode of the probe, and real-time detection is realized through the pressure sensor, the bracket and the infrared temperature sensor; 2) for parts of substances that undergo a change of state at a certain temperature (solid-liquid transition); 3) measuring the melting point (temperature at solid-liquid transition) of the substance by a temperature changing mode; 4) the probe is set to a temperature changing mode, the temperature is increased at the speed of 1 ℃ per second, the substance is in close contact with the probe by using the bracket, and the probe has a certain pressure value at the initial time; 5) monitoring the accumulated temperature of the measured object and the temperature of the heating source in real time along with the change of the temperature, closely monitoring the change of the pressure sensor, and determining the surface temperature of the measured object corresponding to the time point when the detection value of the pressure sensor changes greatly as the melting point of the substance; 6) the melting point of a substance is defined by determining the mean and standard deviation five times.
The quantitative shallow sensation comprehensive analysis early warning system is used as an instrument for thermodynamic identification of material purity: the thermodynamic identification of the purity of the substance is specifically as follows: 1) firstly, measuring the melting point of a standard substance A through the operation flow for accurately measuring the melting point of the substance; 2) measuring the melting point of the substance to be identified by the same process; 3) if the melting point of the standard is more than 5%, a difference in the composition of the substance may be suspected and further analysis of the composition of the substance may be performed.
The quantitative superficial sensation comprehensive analysis early warning system is used as an instrument for quality identification of temperature sensitive substances and thermolabile materials: quality identification and protection of substances sensitive to temperature or of thermolabile materials (such as leather, foam, etc.): 1) on the basis of accurately measuring the melting point of a substance, an automatic rewarming system is additionally used; 2) firstly, measuring the dangerous temperature (melting point) of a standard substance or material through an operation flow for accurately measuring the melting point of the substance; 3) further performing purity or quality identification on such substances and materials by using the operation of thermodynamic identification of substance purity; 4) during the measurement process or when the material is in a local heating state due to other reasons, the surface temperature of the material is monitored in real time, and the material can be automatically started or converted into a rewarming mode immediately within the range of reaching the dangerous temperature, so that the material is restored to the safe value range, and the protection of the specific material is realized.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples for carrying out the invention, and that various changes in form and details may be made therein without departing from the spirit and scope of the invention in practice. The components and structures of the present embodiments that are not described in detail are well known in the art and do not constitute essential structural elements or elements.

Claims (10)

1. Quantitative superficial sensation comprehensive analysis early warning system, characterized by: the probe comprises a probe body, wherein the probe body comprises an upper cover (17), a cold-heat exchange device (5), a probe shell (12) and an infrared silicon lens (11), one end of the cold-heat exchange device (5) is sleeved with the probe shell (12), the other end of the cold-heat exchange device is sleeved with the upper cover (17), and the infrared silicon lens (11) is arranged on the end face of the probe shell (12); the cold and heat exchange device (5) is a cylindrical heat dissipation shell (5-2) with a heat dissipation fin (5-1) at one end, a contact head (5-4) arranged along the axis direction of the cylinder is arranged in the cylindrical heat dissipation shell (5-2), an infrared temperature sensor (1) and a microprocessor (9) are arranged at one end of the contact head (5-4), and a pressure sensor (2) is arranged at the other end of the contact head; the probe shell (12) is cylindrical, a temperature detection device (7) is arranged in the probe shell, the temperature detection device (7) is annular and is tightly attached to the infrared silicon lens (11), and the infrared silicon lens (11) is also connected with the temperature changing device (4) and the pressure sensor (2) through a heat conduction spring (13) and a force conduction spring (14) respectively; the temperature changing device (4) and the contact heads (5-4) are positioned on the same axis correspondingly, the temperature changing device (4) and the cold-heat exchange device form an environment generating unit (3), the environment generating unit (3) is electrically connected with the microprocessor (9) through a temperature control relay (6), and the infrared temperature sensor (1), the pressure sensor (2) and the temperature detecting device (7) are respectively electrically connected with the microprocessor (9).
2. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 1, wherein: the probe is characterized by further comprising a direct current power supply (8) and a PC (10), wherein the direct current power supply (8) and the PC (10) are arranged outside the probe, an external wiring hole (15) is formed in the end face of the upper cover (17), the direct current power supply (8) supplies power to the environment generating unit (3) and the microprocessor (9) through the external wiring hole (15), and the microprocessor (9) is in electric signal connection with the PC (10).
3. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 1, wherein: the contact heads (5-4) are cylindrical, the outer wall of the cylinder is provided with an internal wiring hole, and the pressure sensor (2) and the temperature detection device (7) are respectively and electrically connected with the microprocessor (9) through the internal wiring hole.
4. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 3, wherein: the temperature changing device (4) is a semiconductor refrigeration piece, the semiconductor refrigeration piece and the pressure sensor (2) are both of an annular structure, the pressure sensor (2) is sleeved on the contact head (5-4), the force guide springs (14) are multiple, the outer sides of the contact heads (5-4) are uniformly distributed along the axial direction of the contact heads (5-4), one end of each force guide spring (14) is fixedly connected with the pressure sensor (2), the other end of each force guide spring is tightly attached to the infrared silicon lens, one or more heat guide springs (13) are provided, one end of each heat guide spring is fixed on the semiconductor refrigeration piece, and the other end of each heat guide spring is tightly attached to the infrared silicon lens and is positioned on the inner side of the force guide spring (14); the temperature detection device (7) is an annular thermistor, the diameter of the annular thermistor is larger than that of the pressure sensor (2), the diameter of the semiconductor refrigeration piece is the same as that of the contact head (5-4), and the annular thermistor, the semiconductor refrigeration piece, the pressure sensor (2) and the contact head (5-4) are coaxial.
5. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 1 or 2, characterized in that: a bracket fixing hole (16) is formed in the side wall of the upper cover (17); and threads are arranged in the support fixing holes (16).
6. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 5, wherein: the support fixing hole (16) is connected with a support through threads, the support consists of a support base and a support aluminum core supporting tube, one end of the support aluminum core supporting tube is fixed on the support base, and the other end of the support aluminum core supporting tube is detachably connected with the support fixing hole (16) through threads.
7. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 1, wherein: the probe is made of a titanium alloy material; the infrared silicon lens (11) has a transmittance of more than 90% for infrared light and a heat conductivity coefficient of 150
Figure DEST_PATH_IMAGE002
(ii) a The heat-conducting spring is made of copper material and has heat conductivity of 410
Figure DEST_PATH_IMAGE002A
(ii) a The elastic coefficient of the force guide spring
Figure DEST_PATH_IMAGE004
Is 0.4
Figure DEST_PATH_IMAGE006
The relationship between the displacement of the spring and the pressure is
Figure DEST_PATH_IMAGE008
Wherein
Figure DEST_PATH_IMAGE010
In order to act on the pressure sensor in a pressure-sensitive manner,
Figure DEST_PATH_IMAGE004A
is the elastic coefficient of the spring and is,
Figure DEST_PATH_IMAGE012
is the amount of displacement of the spring.
8. The quantitative superficial sensation comprehensive analysis and early warning system according to claim 1, wherein: the speed of the temperature rise and the speed of the temperature fall of the infrared silicon lens (1) are 1 ℃/s; the temperature changing device (4) is a semiconductor refrigerating sheet, and the temperature changing device (4), the pressure sensor (2) and the cold-heat exchange device (5) are all of hollow structures and provide light paths between the infrared silicon lens (11) and the infrared temperature sensor (1).
9. A quantitative superficial sensation comprehensive analysis and early warning method is characterized by comprising the following steps: the method comprises the following specific steps:
(1) the probe is set into a temperature changing mode through a PC (10), the initial test temperature is set to be 30-32 ℃, and then the temperature is transmitted to a microprocessor (9);
(2) after the microprocessor (9) receives the temperature change instruction, the microprocessor (9) changes the temperature of the contact surface of the temperature change device (4) and the heat conduction spring (13) through the temperature control relay (6), and then the temperature is conducted to the infrared silicon lens (11) through the heat conduction spring (13), so that the temperature change of the infrared silicon lens (11) is realized within-5-50 ℃; the temperature of the infrared silicon lens (1) is monitored in real time through the temperature detection device (7), and the monitored temperature is transmitted to the microprocessor (9);
(3) the upper limit and the lower limit of the safe temperature are set to 44 ℃ and 10.8 ℃ through a PC (10), the detected object is detected through an infrared silicon lens of a probe, an infrared temperature sensor 1 detects the temperature of the detected object through an infrared silicon lens (11), and the detected temperature is transmitted to a microprocessor (9); the microprocessor (9) transmits the data detected by the temperature detection device (7) and the infrared temperature sensor (1) to the PC (10) for data storage, data analysis and filing;
(4) when the temperature of the measured object reaches the threshold value, an audible and visual alarm device in the PC (10) gives out early warning to remind the user of paying attention for 30 s; when the infrared temperature sensor (1) detects that the accumulated temperature of the measured object exceeds the warning temperature for more than 30s, the microprocessor (9) sends out an alarm signal and automatically changes the voltage at two ends of the temperature changing device (4) to carry out a cold and heat source rewarming mode, so that the temperature of the measured object returns to a safe temperature range of 30-32 ℃;
(5) if the infrared silicon lens (1) moves, a pressure signal is transmitted to the pressure sensor (2) through the force guide spring (14), the pressure sensor (2) transmits the movement information of the detected infrared silicon lens (11) to the microprocessor (9), and the data detected by the microprocessor (9) is transmitted to the PC (10) for data storage, data analysis and filing.
10. The use of a quantitative superficial sensation comprehensive analysis and early warning system as claimed in any one of claims 1 to 8, wherein: the quantitative superficial sensation comprehensive analysis early warning system is used as a heat source or a cold source and becomes auxiliary medical equipment for carrying out thermal therapy or cold therapy; or as an instrument for measuring nerve conduction; or an instrument for the accurate determination of the melting point of a substance; or an apparatus for the thermodynamic identification of the purity of a substance: or an instrument for quality control of temperature-sensitive substances and thermolabile materials.
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