WO1993007250A1 - Novel skin and hand cleansing process and compositions - Google Patents

Novel skin and hand cleansing process and compositions Download PDF

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Publication number
WO1993007250A1
WO1993007250A1 PCT/AU1992/000539 AU9200539W WO9307250A1 WO 1993007250 A1 WO1993007250 A1 WO 1993007250A1 AU 9200539 W AU9200539 W AU 9200539W WO 9307250 A1 WO9307250 A1 WO 9307250A1
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Prior art keywords
skin
water
composition
composition according
alkanol
Prior art date
Application number
PCT/AU1992/000539
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French (fr)
Inventor
Bruno Anthony Gluck
Original Assignee
Novapharm Research (Australia) Pty. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novapharm Research (Australia) Pty. Ltd. filed Critical Novapharm Research (Australia) Pty. Ltd.
Publication of WO1993007250A1 publication Critical patent/WO1993007250A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/201—Monohydric alcohols linear
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C11D3/485—Halophors, e.g. iodophors

Definitions

  • the present invention relates to a process for antiseptically cleaning the skin and hands and compositions therefor.
  • antiseptic skin and hand cleansing is effected by treating the hands with an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
  • an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
  • an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
  • a method for cleansing skin comprising applying the composition of this invention onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
  • Suitable alkanols are the lower alkanols such as methanol, ethanol, n-propanol or isopropanol. Alkanols might be single or mixtures thereof and should not be less than
  • aromatic alcohols such as benzyl alcohol, phenoxyethyl or - propyl alcohol might be added to a maximum of 5 % calculated on the total volume of the final formulation.
  • the cationic compound may be a quaternary ammonium compound or a bis or di-bis-biguanidine:
  • the composition may also contain a microbiocidal compound which may be any commonly used for disinfection.
  • the microbiocide may be a cationic microbiocide, an iodophor, a bacteriostat or a phenol or derivative thereof.
  • Suitable quaternary ammonium compounds are benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, hexadecylpyridinium chloride, alkylisoquinolinium bromide or hexadecyltrimethylammonium bromide. Most preferably the quaternary ammonium compound is benzalkonium chloride.
  • a preferred biguanidine is chlorhexidine gluconate.
  • a preferred iodophor is povidone iodine.
  • a preferred bacteriostat is hexachlorophene or triclosan.
  • a preferred phenol is 2-hydroxy diphenyl.
  • Surfactants should preferably be mild to the skin such as the sodium sulfosuccinates, monoethanolamine lauryl ethoxy sulfonates or amphoterics such as dodecyl propylamino acetic acid.
  • the nonionic surfactant may be the ethoxy-derivative of either a fatty alkanol or alkyl phenyl. The alkanol may be present up to 80 parts by volume.
  • the time of application is from a minimum of about 30 to a maximum until most or all of the alkanol has evaporated, but preferably about 90 seconds.
  • compositions of this invention may be used to disinfect the skin.
  • Advantageously foaming agents can be included in the compositions such as the alkyl mono or diethanolamine of oleyl-, coco-, lauryl- or undecylenic acid or thickening agent such as carbopol or hydroxyethyl cellulose.
  • This novel preparation provides a new process of complete hand and skin disinfection by reducing scrubbing time considerably from the standard time of 5 minutes by 2 to 3 minutes without dermatological damage to the skin on repeated applications. This method is particularly applicable to human handwashing.
  • Example 1 The hand wash of Example 1 was evenly applied for 60 seconds on dry hands to 5 cover all parts and a little water added with a routine washing movement of the hands. A copious foam developed similar to washing with soaps. After 30 seconds the hands were
  • compositions of the present invention will find wide use in medical, veterinary, and food processing industries.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention provides an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant. The compositions may also comprise a biocide. The present invention further provides a method for cleansing skin comprising applying the composition of this invention onto the skin allowing the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.

Description

Novel Skin And Hand Cleansing Process And Compositions
Technical Field
The present invention relates to a process for antiseptically cleaning the skin and hands and compositions therefor. Background Art
It has been common practice worldwide that preoperative hand cleansing has been carried out in either of the two following ways.
In one instance antiseptic skin and hand cleansing is effected by treating the hands with an anti-microbial agent dissolved in an alcohol such as ethyl or isopropylalcohol or a mixture thereof at high concentrations, usually 70% v/v, or by scrubbing the hands or skin for 5 minutes with an antibacterial aqueous soap solution.
Although the use of antiseptic alcoholic solutions achieves complete disinfection of the hands and skin, repeated application can cause, due to dehydration, reddening with irritation and in some cases breaking of the skin. In the other instance hand scrubbing procedures with aqueous germicidal soaps over the prescribed 5 minute period can cause considerable, but not complete reduction of the bacterial flora on the skin and although dehydration of the skin is largely reduced in comparison to antiseptic alcoholic preparations, repeated prolonged scrubbing can produce similar deterioration of the skin. Disclosure Of The Invention
According to one broad form of the present invention there is provided an antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
According to another broad form of this invention there is provided a method for cleansing skin comprising applying the composition of this invention onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
Suitable alkanols are the lower alkanols such as methanol, ethanol, n-propanol or isopropanol. Alkanols might be single or mixtures thereof and should not be less than
40% and not more than 80% and generally not more than 60% of the total volume. Further aromatic alcohols such as benzyl alcohol, phenoxyethyl or - propyl alcohol might be added to a maximum of 5 % calculated on the total volume of the final formulation.
The cationic compound may be a quaternary ammonium compound or a bis or di-bis-biguanidine:
The composition may also contain a microbiocidal compound which may be any commonly used for disinfection. For example, the microbiocide may be a cationic microbiocide, an iodophor, a bacteriostat or a phenol or derivative thereof.
Suitable quaternary ammonium compounds are benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, hexadecylpyridinium chloride, alkylisoquinolinium bromide or hexadecyltrimethylammonium bromide. Most preferably the quaternary ammonium compound is benzalkonium chloride. A preferred biguanidine is chlorhexidine gluconate. A preferred iodophor is povidone iodine. A preferred bacteriostat is hexachlorophene or triclosan.
A preferred phenol is 2-hydroxy diphenyl.
Surfactants should preferably be mild to the skin such as the sodium sulfosuccinates, monoethanolamine lauryl ethoxy sulfonates or amphoterics such as dodecyl propylamino acetic acid. Where a catiomc biocide is used, the nonionic surfactant may be the ethoxy-derivative of either a fatty alkanol or alkyl phenyl. The alkanol may be present up to 80 parts by volume.
______ I
The time of application is from a minimum of about 30 to a maximum until most or all of the alkanol has evaporated, but preferably about 90 seconds.
Furthermore on application of a small amount of water excellent sudsing cleansing is obtained on normal handwashing movements, for 15 to 30 seconds. The hands are then rinsed under running water and dried.
The compositions of this invention may be used to disinfect the skin. Advantageously foaming agents can be included in the compositions such as the alkyl mono or diethanolamine of oleyl-, coco-, lauryl- or undecylenic acid or thickening agent such as carbopol or hydroxyethyl cellulose.
The benefit of this novel preparation is that it provides a new process of complete hand and skin disinfection by reducing scrubbing time considerably from the standard time of 5 minutes by 2 to 3 minutes without dermatological damage to the skin on repeated applications. This method is particularly applicable to human handwashing.
Best And Other Modes For Carrying Out The Invention The present invention will now be described with reference to the following examples which should not be construed as limiting on the scope thereof.
Example 1 Hand Wash
Ethanol 70.0 ml
Triclosan 1.5 g
Laureth 2 5.0 g
Cocodiethanolamine 4.0 g Hydroxypropylcellulose 1.0 g
Water to final volume 100.0 ml Example 2 Demonstration Of Effectiveness Of The Present Composition
The hand wash of Example 1 was evenly applied for 60 seconds on dry hands to 5 cover all parts and a little water added with a routine washing movement of the hands. A copious foam developed similar to washing with soaps. After 30 seconds the hands were
/ ^ rinsed well under running tap water and dried with a paper towel.
Two forefingers were then placed for 30 seconds on an unseeded agar plate, then on an agar plate seeded with Escherichia coli and again on unseeded agar. 10 None of the plates after incubation of 48 hours showed any growth. This demonstrated that not only complete disinfection after the novel washing process of one and a half minutes was achieved but also residual antibacterial properties on the skin by inhibiting growth of the seeded agar with E. coli after being in contact with it. Using the same conditions a glove juice test gave a log reduction between 1.5 to 2.0. 15
20
25
30
35
40
Figure imgf000005_0001
During the whole mixing process care has to be taken to ensure that the pH is always below 6.0 and is to be finally adjusted to 4.5 with either citric acid or triethanolamine.
Industrial Applicability It should be clear that the compositions of the present invention will find wide use in medical, veterinary, and food processing industries.
The foregoing describes only some embodiments of the present invention and modifications obvious to those skilled in the art can be made thereto without departing from the scope of the invention.

Claims

Claims
1. An antiseptic cleansing composition comprising an alkanol and an aqueous concentrate of a surfactant.
2. The composition of claim 1 further comprising a biocide.
5 3. The composition according to claim 1 or claim 2 where the alkanol is a rκ water-soluble aliphatic alcohol of not less than 40% and not more than 80% of the total volume.
4. The composition according to any one of claims 1 to 3 wherein the alkanol is selected from the group consisting of ethyl and n-propyl alcohol. 10
5. The composition according to any one of claims 1 to 4 wherein the surfactant is selected from the group consisting of an anionic, non-ionic and an amphoteric surfactant.
6. The composition according to any one of claims 1 to 5 wherein the biocide is selected from the group consisting of a water-soluble cationic bacteriocide, an iodophor,
15 or and a water-insoluble bacteriostat.
7. The composition according to claim 6 wherein the water-soluble bacteriocide is chlorhexidine gluconate, the iodophor is povidone iodine, and the water- insoluble bacteriostat is triclosan or hexachlorophene.
8. A method for cleansing skin comprising applying the composition of claim 20 1 onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
9. The method of claim 8 wherein the period of time is between 30 and 90 seconds.
10. The method according to claim 8 or claim 9 further comprising allowing 25 the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.
11. The method of claim 10 wherein the skin is rinsed with water.
AMENDED CLAIMS
[received by the Intemationai Bureau on 18 February 1993 (18.02.93) , original claim 4 amended ; other claims unchanged (1 page)] Claims:
1. An antiseptic cleansing composition comprising an allkanol and an aqueous concentrate of a surfactant.
2. The composition of claim 1 further comprising a biocide. 3. The composition according to claim 1 or claim 2 where the alkanol is a water- soluble aliphatic alcohol of not less than 40% and not more than 80% of the total volume.
4. The composition according to any one off claims 1 to 3 wherein the alkanol is selected from the group consisting of ethanol, n-propanol and isopropanol.
5. The composition according to any one of claims 1 to 4 wherein the surfactant is selected from the group consisting of an anionic, non-ionic and an amphoteric surfactant.
6. The composition according to any one of claims 1 to 5 wherein the biocide is selected from the group consisting of a water-soluble cationic bacteriocide, an iodophor, or and a water-insoluble bacteriostat. 7. The composition according to claim 6 wherein the water-soluble bacteriocide is chlorhexidine gluconate, the iodophor is povidone iodine, and the water-insoluble bacteriostat is triclosan or hexachlorophene.
8. A method for cleansing skin comprising applying the composition of claim 1 onto the skin in a sufficient amount and for a sufficient period of time in order to achieve asepsis.
9. The method of claim 8 wherein the period of time is between 30 and 90 seconds.
10. The method according to claim 8 or claim 9 further comprising allowing the alkanol in the composition on the skin to evaporate whereby the skin is substantially dry, applying a small amount of water to the substantially dry skin, washing the skin under foam generation and finally rinsing the skin.
11. The method of claim 10 wherein the skin is rinsed with water.
PCT/AU1992/000539 1991-10-09 1992-10-09 Novel skin and hand cleansing process and compositions WO1993007250A1 (en)

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AUPK879891 1991-10-09
AUPK8798 1991-10-09

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Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689767A3 (en) * 1994-06-27 1996-03-27 Becton Dickinson Co Skin disinfecting formulations
WO1997035475A1 (en) * 1996-03-27 1997-10-02 Antiseptica Chemisch-Pharmazeutische Produkte Gmbh Hand disinfectant
WO1997046218A2 (en) * 1996-06-04 1997-12-11 Ciba Specialty Chemicals Holding Inc. Concentrated liquid formulations comprising a microbicidally active ingredient
US5700842A (en) * 1995-11-01 1997-12-23 Kimberly-Clark Worldwide, Inc. Methods of incorporating a hydrophobic substance into an aqueous solution
WO1998001110A1 (en) * 1996-07-10 1998-01-15 Calgon Vestal, Inc. Triclosan skin wash with enhanced efficacy
EP0882446A1 (en) * 1997-06-02 1998-12-09 Gojo Industries,Inc. Antimicrobial skin cleansing compositions
US5888524A (en) * 1995-11-01 1999-03-30 Kimberly-Clark Worldwide, Inc. Antimicrobial compositions and wet wipes including the same
WO2000048554A2 (en) * 1999-02-16 2000-08-24 Ecolab Inc. Synergistic antimicrobial skin washing compositions
FR2791890A1 (en) * 1999-04-12 2000-10-13 Gilbert Lab COLORED ALCOHOLIC CHLORHEXIDINE SOLUTION AND MANUFACTURING METHOD THEREOF
WO2001041567A1 (en) * 1999-12-13 2001-06-14 Ethicon, Inc. Deep penetrating antimicrobial compositions
WO2001064034A1 (en) * 1999-05-19 2001-09-07 Stack, Kevin Antimicrobial sanitizing lotion with skin protection properties
US6531434B1 (en) * 1997-05-20 2003-03-11 Novapharm Research (Australia) Pty. Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism
US6579516B1 (en) 1995-06-13 2003-06-17 Zahra Mansouri Methods of delivering materials into the skin, and compositions used therein
WO2004101725A1 (en) * 2003-05-15 2004-11-25 Greenbridge Environmental Control Limited Anti-viral cleaning composition
WO2004101726A3 (en) * 2003-05-15 2005-03-17 Greenbridge Environmental Cont Anti-viral and anti-bacterial cleaning composition
WO2006062846A2 (en) * 2004-12-09 2006-06-15 The Dial Corporation Compositions having a high antiviral and antibacterial efficacy
WO2006062897A2 (en) * 2004-12-09 2006-06-15 The Dial Corporation Compositions having a high antiviral and antibacterial efficacy
DE102004062775A1 (en) * 2004-12-21 2006-06-29 Stockhausen Gmbh Alcoholic pump foam
AU2005209647B2 (en) * 1999-12-13 2008-10-02 Ethicon, Inc. Deep penetrating antimicrobial compositions
US7566740B2 (en) * 1998-10-06 2009-07-28 Bml Pharmaceuticals, Inc. Method of treating mucositis
WO2012119644A1 (en) * 2011-03-08 2012-09-13 Sca Hygiene Products Ab Low alcohol antimicrobial cleansing composition

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0689767A3 (en) * 1994-06-27 1996-03-27 Becton Dickinson Co Skin disinfecting formulations
US7771753B2 (en) 1995-06-13 2010-08-10 Laboratory Skin Care, Inc. Topical formulations comprising ceramic hydroxyapatite particles
US6579516B1 (en) 1995-06-13 2003-06-17 Zahra Mansouri Methods of delivering materials into the skin, and compositions used therein
US7655250B2 (en) 1995-06-13 2010-02-02 Laboratory Skin Care, Inc. Topical formulations comprising ceramic hydroxyapatite particles
US5700842A (en) * 1995-11-01 1997-12-23 Kimberly-Clark Worldwide, Inc. Methods of incorporating a hydrophobic substance into an aqueous solution
US5888524A (en) * 1995-11-01 1999-03-30 Kimberly-Clark Worldwide, Inc. Antimicrobial compositions and wet wipes including the same
US6080417A (en) * 1996-03-27 2000-06-27 Antiseptica Chemisch-Pharmazeutische Produkte Gmbh Hand disinfectant
WO1997035475A1 (en) * 1996-03-27 1997-10-02 Antiseptica Chemisch-Pharmazeutische Produkte Gmbh Hand disinfectant
WO1997046218A3 (en) * 1996-06-04 1998-03-12 Ciba Sc Holding Ag Concentrated liquid formulations comprising a microbicidally active ingredient
US6358906B1 (en) 1996-06-04 2002-03-19 Ciba Specialty Chemicals Corporation Concentrated liquid accumulations comprising a microbicidally active ingredient
CN1133418C (en) * 1996-06-04 2004-01-07 西巴特殊化学品控股有限公司 Concentrated liquid formulations comprising microbicidally active ingredient
WO1997046218A2 (en) * 1996-06-04 1997-12-11 Ciba Specialty Chemicals Holding Inc. Concentrated liquid formulations comprising a microbicidally active ingredient
WO1998001110A1 (en) * 1996-07-10 1998-01-15 Calgon Vestal, Inc. Triclosan skin wash with enhanced efficacy
US5955408A (en) * 1996-07-10 1999-09-21 Steris Inc. Triclosan skin wash with enhanced efficacy
US6090772A (en) * 1996-07-10 2000-07-18 Steris Inc Triclosan skin wash with enhanced efficacy
US6531434B1 (en) * 1997-05-20 2003-03-11 Novapharm Research (Australia) Pty. Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism
US7163914B2 (en) 1997-05-20 2007-01-16 Novapharm Research (Australia) Pty. Ltd. Alkylpolyglucosides containing disinfectant compositions active against pseudomonas microorganism
EP0882446A1 (en) * 1997-06-02 1998-12-09 Gojo Industries,Inc. Antimicrobial skin cleansing compositions
US7566740B2 (en) * 1998-10-06 2009-07-28 Bml Pharmaceuticals, Inc. Method of treating mucositis
WO2000048554A2 (en) * 1999-02-16 2000-08-24 Ecolab Inc. Synergistic antimicrobial skin washing compositions
WO2000048554A3 (en) * 1999-02-16 2000-11-02 Ecolab Inc Synergistic antimicrobial skin washing compositions
EP1044686A1 (en) * 1999-04-12 2000-10-18 Laboratoires Gilbert SA Alcoholic coloured chlorhexidine solution and its manufacturing process
FR2791890A1 (en) * 1999-04-12 2000-10-13 Gilbert Lab COLORED ALCOHOLIC CHLORHEXIDINE SOLUTION AND MANUFACTURING METHOD THEREOF
WO2001064034A1 (en) * 1999-05-19 2001-09-07 Stack, Kevin Antimicrobial sanitizing lotion with skin protection properties
AU2005209647B2 (en) * 1999-12-13 2008-10-02 Ethicon, Inc. Deep penetrating antimicrobial compositions
WO2001041567A1 (en) * 1999-12-13 2001-06-14 Ethicon, Inc. Deep penetrating antimicrobial compositions
WO2004101725A1 (en) * 2003-05-15 2004-11-25 Greenbridge Environmental Control Limited Anti-viral cleaning composition
WO2004101726A3 (en) * 2003-05-15 2005-03-17 Greenbridge Environmental Cont Anti-viral and anti-bacterial cleaning composition
US7915216B2 (en) 2003-05-15 2011-03-29 Medigreen Ood Anti-viral and anti-bacterial cleaning composition
WO2006062846A3 (en) * 2004-12-09 2007-01-18 Dial Corp Compositions having a high antiviral and antibacterial efficacy
WO2006062897A3 (en) * 2004-12-09 2007-01-18 Dial Corp Compositions having a high antiviral and antibacterial efficacy
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