CN111387189A - Disinfectant composition - Google Patents

Disinfectant composition Download PDF

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CN111387189A
CN111387189A CN202010228737.4A CN202010228737A CN111387189A CN 111387189 A CN111387189 A CN 111387189A CN 202010228737 A CN202010228737 A CN 202010228737A CN 111387189 A CN111387189 A CN 111387189A
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acid
sulfonate
disinfectant composition
hydrogen peroxide
sodium
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黄新河
雷德清
雷惠
黄开华
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Chengdu Hanhuang Biotechnology Co ltd
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Chengdu Hanhuang Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a disinfectant composition, which comprises: 10-55 wt% of an activating agent, 30-85 wt% of a hydrogen peroxide releasing agent and 1-15 wt% of an auxiliary agent; in order to further improve the disinfection effect, the composition can also comprise a stabilizer, wherein the stabilizer accounts for 1-10% of the total mass of the disinfectant composition. The disinfection composition is a solid composition, can be stably stored for a long time, can generate strong lipophilic peroxyacid after being dissolved in water, greatly improves the antibacterial activity and the quick killing rate of broad-spectrum microorganisms, is safer and more stable, and has wide application prospect.

Description

Disinfectant composition
Technical Field
The invention belongs to the technical field of disinfection articles, and particularly relates to a disinfection composition.
Background
Peracetic acid has been used as a disinfectant in various fields for decades due to its high oxidizing power, broad bactericidal efficacy and environmentally friendly characteristics; but also because of its high corrosiveness, high reactivity and instability, peracetic acid is difficult to preserve for a long time, which in turn limits its use in many applications. Much effort has been made by researchers to produce stable peroxyacids, but eventually almost all peroxyorganic acids have been found to be unstable, they cannot be stored in bottles for use, and on-site production of peroxyacids is ineffective, expensive and inconvenient for most disinfection applications.
Hydrogen peroxide is probably the safest sterilant because it decomposes to produce non-toxic oxygen and water, however, hydrogen peroxide has limited bactericidal capacity and is not effective against many organisms and typically requires concentrations greater than 7% hydrogen peroxide to be a sterilant. The prior art has developed peroxyacid-free hydrogen peroxide-based formulations, but these formulations suffer from the disadvantage that relatively high hydrogen peroxide concentrations are still required, while the antimicrobial effect on difficult to kill microorganisms such as mycobacteria and spores is low.
Disclosure of Invention
Aiming at the prior art, the invention provides a disinfectant composition to solve the problems that peroxyacid disinfectant is difficult to store and has poor bactericidal capability.
In order to achieve the purpose, the invention adopts the technical scheme that a disinfectant composition is provided, and the disinfectant composition comprises the following components in percentage by mass:
10-55% of an activating agent, 30-85% of a hydrogen peroxide releasing agent and 1-15% of an auxiliary agent; the activator comprises a compound shown as a formula I and/or a compound shown as a formula II, wherein R is a linear or branched alkyl of C1-C19,
Figure BDA0002428621970000021
on the basis of the technical scheme, the invention can be further improved as follows.
Further, the disinfectant composition comprises the following components in percentage by mass:
15-50% of an activating agent, 40-75% of a hydrogen peroxide releasing agent and 5-10% of an auxiliary agent.
Further, the disinfectant composition comprises the following components in percentage by mass:
30% of activating agent, 60% of hydrogen peroxide releasing agent and 10% of auxiliary agent.
The active agent and the hydrogen peroxide releasing agent in the disinfection composition exist in a solid form, and are not mutually influenced in the ordinary storage process, so that the long-time stable storage of the disinfection composition can be realized. When disinfection is needed, the disinfection composition is dissolved in water according to a certain proportion, the active agent and the hydrogen peroxide releasing agent react to generate peroxy acid in the solution, and the generated peroxy acid and the auxiliary agent act synergistically to obviously enhance the antimicrobial efficacy and the cleaning function of the disinfection composition; the specific process is shown in fig. 1. The principle of sterilization of the disinfecting composition of the invention is illustrated by taking sodium percarbonate as an example:
upon dissolving the solid disinfectant composition of the present invention in water, the hydrogen peroxide source 1 releases a peroxide anion 2, and the released peroxide anion 2 reacts with an activator 3 to form a peroxyacid 4, which is in equilibrium with a peroxyacid anion 5, wherein R is a linear and branched C1 to C19 alkyl group. Both the peroxy acid 4 and the peroxy acid anion 5 are activated peroxy acids which kill bacteria on substrates and surfaces.
Further, the activating agent is one or a mixture of more of 4-acetoxybenzoic acid, 4-nonanoyloxybenzene sodium sulfonate, 4-lauroyloxybenzene sodium sulfonate, 4-decanoyloxybenzoic acid, 4-lauroyloxybenzoic acid, 4-octylbenzene sodium sulfonate, 4-decanoyloxybenzene sodium sulfonate, 4-nonanoyloxybenzoic acid and 4-octyloxybenzoic acid.
The invention preferentially adopts the compounds with the structures shown in the formulas I and II as the active agents, because the compounds with the structures can generate lipophilic peroxy acid after reacting with the hydrogen peroxide releasing agent, and the lipophilic peroxy acid can better penetrate the cell wall of bacteria such as mycobacteria, the disinfection substance can directly reach the interior of the bacteria, the bacteria which are difficult to eliminate by the conventional disinfectants can be quickly and efficiently killed, and the sterilization effect is obvious.
Further, the hydrogen peroxide releasing agent is sodium percarbonate, lithium percarbonate, potassium percarbonate, lithium perborate, sodium perborate hydrate, urea hydrogen peroxide adduct or PVP peroxide.
The hydrogen peroxide releasing agent is solid, can be stably stored for a long time at normal temperature, and can quickly react with the active agent after meeting water to release low-concentration peroxide, and the low-concentration peroxide and the active agent have the effects of disinfection and sterilization.
Further, the adjuvant is an alkylbenzene sulfonate, an alkyl ethoxylated sulfonate, an alkylphenol ethoxylated sulfonate, an alkyl phosphonate, an alkyl aryl ether phosphonate, an alkyl ether phosphonate, a lauryl sulfate, dioctyl sodium sulfosuccinate quaternary ammonium salt, polyquaternary ammonium salt, petroleum sulfonate, naphthalene sulfonate, olefin sulfonate or alkyl carboxylate.
Further, the disinfectant composition also comprises a stabilizer, wherein the stabilizer accounts for 1-10% of the total mass of the disinfectant composition.
Further, the stabilizer is phosphoric acid, phosphonate ester, aminophosphonic acid, diphosphonic acid, tris (methylenephosphonic acid) 1-hydroxyethylidenediphosphonic acid, phytic acid, dipicolinic acid or ethylenediamine-N, N' -disuccinic acid.
The stabilizing agent can stabilize hydrogen peroxide and peroxy acid, avoid the too fast decomposition of the hydrogen peroxide and the peroxy acid, and improve the sterilization effect of the disinfectant.
When the disinfection composition is used, 1 part by mass of the solid composition is dissolved in 10 parts by mass to 99 parts by mass of water to prepare a solution, and the prepared solution can be directly used in various occasions, can resist various microorganisms at room temperature, and has good killing effect on microorganisms which are difficult to kill, such as mycobacteria, spores and the like.
The invention has the beneficial effects that: all components of the disinfection composition exist in a solid form, so that the disinfection composition is beneficial to long-time stable storage, and can be directly mixed with water according to a certain proportion when in use, so that the problems that the existing disinfectant is poor in stability, not beneficial to long-time storage, troublesome to operate due to field preparation and incapable of achieving disinfection effect can be effectively solved. In addition, the disinfection composition can generate lipophilic peroxyacid, greatly improves the antibacterial activity and the quick killing rate to broad-spectrum microorganisms, and has wide application prospect.
Drawings
FIG. 1 illustrates the chemical reactions that occur during the sterilization of the disinfecting composition of the present invention.
Detailed Description
The following examples are provided to illustrate specific embodiments of the present invention.
Examples 1, 2:
the solid disinfectant compositions of examples 1 and 2 were prepared by mixing sodium 4-nonanoylbenzenesulfonate, sodium dodecylbenzenesulfonate and sodium percarbonate containing 27% hydrogen peroxide, and the resulting solid disinfectant compositions were added to deionized water to make disinfectant solutions. The resulting test sample compositions were tested for bactericidal activity against pseudomonas aeruginosa (Pa) and staphylococcus aureus (Sa) over a 1min contact time and the results are listed in table 1.
TABLE 1 fungicidal Activity of the germicidal solutions against Pseudomonas aeruginosa and Staphylococcus aureus
Figure BDA0002428621970000041
Note: SNOBS is sodium 4-nonanoylbenzene sulfonate; NOBA is 4-nonanoyloxybenzoic acid; SDBS is sodium dodecyl benzene sulfonate; SPC was sodium percarbonate, 27% H2O2。
The results show that both sample compositions contained only about 0.27-0.35% hydrogen peroxide, but exhibited superior bactericidal activity, with bactericidal levels reduced by more than 4L og10 after 1min exposure example 1 shows superior efficacy against staphylococcus aureus as zero bacterial survival, about 5.8L og10 bacteria reduced, but slightly less resistance against pseudomonas aeruginosa within 1min, with about 1.1L og10 bacteria surviving and 4.2L og10 bacteria reduced, however, the example 2 disinfection composition has slightly increased levels of bleach activator and sodium percarbonate, with zero bacterial survival against staphylococcus aureus and pseudomonas aeruginosa after 1min exposure, and a reduction of 5.8 and 5.2L og10, respectively.
Both disinfecting compositions demonstrated bactericidal activity against both gram positive and gram negative bacteria and zero bacterial survival with a reduction in 6L og10 in only one minute, in the presence of sodium percarbonate and sodium dodecylbenzene sulphonate, produced from 4-nonanoylbenzene sulphonate or 4-nonanoyloxybenzoic acid, wherein the compositions contained only about 0.35% hydrogen peroxide.
Examples 3, 4, 5, 6:
the solid disinfectant compositions of examples 3, 4, 5 and 6 were prepared according to the composition shown in table 2, in which sodium percarbonate contained 27% hydrogen peroxide, and the resulting solid disinfectant compositions were added to deionized water to prepare disinfectant solutions. The bactericidal activity of the resulting test sample compositions against M.niger and M.avium was tested within 5min of contact and the results are shown in Table 2.
TABLE 2 fungicidal Activity of the germicidal solutions against M.niger and M.avium
Figure BDA0002428621970000051
Figure BDA0002428621970000061
Note that AOBA is 4-acetoxybenzoic acid, SNOBS is 4-nonanoylbenzene sodium sulfonate, L OBA is 4-lauroyloxybenzoic acid, NOBA is 4-nonanoyloxybenzoic acid, SDBS is sodium dodecylbenzene sulfonate, SPC is sodium percarbonate，27％H2O2。
The results show that the disinfectant compositions prepared from example 3 can produce peracetic acid, which shows good efficacy against mycobacterium avium but poor efficacy against mycobacterium niger, surprisingly, the lipophilic peroxy acids, peroxynonanoic acid and peroxylauric acid, which can be produced by the disinfectant compositions prepared from examples 4, 5 and 6, respectively, show excellent antimycobacterial activity, which achieves about 5L g10 and more inhibition against both mycobacterium avium and mycobacterium avium within 5 min.
The results also show that the composition containing only about 0.5% hydrogen peroxide shows excellent activity against both mycobacterium nigrum and mycobacterium avium, showing zero bacterial survival, and an inhibitory activity higher than 5L og10 within 5min of contact time.
While the present invention has been described in detail with reference to the embodiments, it should not be construed as limited to the scope of the patent. Various modifications and changes may be made by those skilled in the art without inventive step within the scope of the appended claims.

Claims (8)

1. The disinfectant composition is characterized by comprising the following components in percentage by mass:
10-55% of an activating agent, 30-85% of a hydrogen peroxide releasing agent and 1-15% of an auxiliary agent; the activator comprises a compound shown as a formula I and/or a compound shown as a formula II, wherein R is a linear or branched alkyl of C1-C19,
Figure FDA0002428621960000011
2. the disinfectant composition according to claim 1, comprising the following components in percentage by mass:
15-50% of an activating agent, 40-75% of a hydrogen peroxide releasing agent and 5-10% of an auxiliary agent.
3. The disinfectant composition according to claim 1, comprising the following components in percentage by mass:
30% of activating agent, 60% of hydrogen peroxide releasing agent and 10% of auxiliary agent.
4. A disinfectant composition according to any one of claims 1 to 3 wherein: the activating agent is one or a mixture of more of 4-acetoxybenzoic acid, 4-nonanoyloxybenzene sodium sulfonate, 4-lauroyloxybenzene sodium sulfonate, 4-decanoyloxybenzoic acid, 4-lauroyloxybenzoic acid, 4-octylbenzene sodium sulfonate, 4-decanoyloxybenzene sodium sulfonate, 4-nonanoyloxybenzoic acid and 4-octyloxybenzoic acid.
5. A disinfectant composition according to any one of claims 1 to 3 wherein: the hydrogen peroxide releasing agent is sodium percarbonate, lithium percarbonate, potassium percarbonate, lithium perborate, sodium perborate hydrate, a urea hydrogen peroxide adduct or PVP peroxide.
6. A disinfectant composition according to any one of claims 1 to 3 wherein: the adjuvant is alkylbenzene sulfonate, alkyl ethoxylated sulfonate, alkylphenol ethoxylated sulfonate, alkyl phosphonate, alkyl aryl ether phosphonate, alkyl ether phosphonate, lauryl sulfate, dioctyl sodium sulfosuccinate quaternary ammonium salt, polyquaternary ammonium salt, petroleum sulfonate, naphthalene sulfonate, olefin sulfonate or alkyl carboxylate.
7. The disinfectant composition according to claim 1, further comprising a stabilizer, wherein said stabilizer is 1-10% of the total mass of the disinfectant composition.
8. The disinfectant composition according to claim 1, characterized in that: the stabilizer is phosphoric acid, phosphonate, aminophosphonic acid, diphosphonic acid, tris (methylenephosphonic acid) 1-hydroxyethylidenediphosphonic acid, phytic acid, dipicolinic acid or ethylenediamine-N, N' -disuccinic acid.
CN202010228737.4A 2020-03-27 2020-03-27 Disinfectant composition Pending CN111387189A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112136809A (en) * 2020-10-12 2020-12-29 浙江施维康生物医学材料有限公司 Compound solid fumigation disinfectant and using method thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1270622A (en) * 1997-07-21 2000-10-18 普罗格特-甘布尔公司 Improved alkylbenzenesulfonate surfactants
CN1288050A (en) * 1999-09-09 2001-03-21 高旭 Multi-functional and high efficiency composite for washing, sterilizing and used as medicine and its prescription technology
CN101803612A (en) * 2010-04-09 2010-08-18 中国人民解放军防化指挥工程学院 Solid binary peroxy acid disinfectant
CN104621180A (en) * 2015-02-02 2015-05-20 山东威高药业股份有限公司 Novel sterilization powder
CN105899072A (en) * 2013-11-11 2016-08-24 怀特利集团控股有限公司 Disinfectant composition
CN108064879A (en) * 2017-11-27 2018-05-25 中国人民解放军陆军防化学院 The application method of Compositional type solid fumigant
CN108124902A (en) * 2017-11-24 2018-06-08 中国人民解放军陆军防化学院 Compositional type low-corrosiveness biochemistry disinfectant and its application method and application
CN109392903A (en) * 2018-11-02 2019-03-01 广东环凯微生物科技有限公司 A kind of peroxycarboxylic acid thimerosal and preparation method thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1270622A (en) * 1997-07-21 2000-10-18 普罗格特-甘布尔公司 Improved alkylbenzenesulfonate surfactants
CN1288050A (en) * 1999-09-09 2001-03-21 高旭 Multi-functional and high efficiency composite for washing, sterilizing and used as medicine and its prescription technology
CN101803612A (en) * 2010-04-09 2010-08-18 中国人民解放军防化指挥工程学院 Solid binary peroxy acid disinfectant
CN105899072A (en) * 2013-11-11 2016-08-24 怀特利集团控股有限公司 Disinfectant composition
CN104621180A (en) * 2015-02-02 2015-05-20 山东威高药业股份有限公司 Novel sterilization powder
CN108124902A (en) * 2017-11-24 2018-06-08 中国人民解放军陆军防化学院 Compositional type low-corrosiveness biochemistry disinfectant and its application method and application
CN108064879A (en) * 2017-11-27 2018-05-25 中国人民解放军陆军防化学院 The application method of Compositional type solid fumigant
CN109392903A (en) * 2018-11-02 2019-03-01 广东环凯微生物科技有限公司 A kind of peroxycarboxylic acid thimerosal and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112136809A (en) * 2020-10-12 2020-12-29 浙江施维康生物医学材料有限公司 Compound solid fumigation disinfectant and using method thereof

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Application publication date: 20200710