CN111346143A - 一种调节肝郁气滞型肥胖的中药组合物及其制备方法 - Google Patents
一种调节肝郁气滞型肥胖的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种调节肝郁气滞型肥胖的中药组合物,其包括:合欢皮、决明子、牛蒡、连翘、枳壳、千金子、补骨脂、甘草,本发明还公开了上述中药组合物的制备方法。本发明的组方配伍合理,能清热利湿、行气助阳、舒肝益气、且无明显肝肾毒性,能有效改善人体肝气郁滞、气机不畅的情况,适合应用到肝郁气滞型肥胖治疗中。
Description
技术领域
本发明涉及医药领域,尤其涉及一种调节肝郁气滞型肥胖的中药组合物及其制备方法。
背景技术
中医学自古便对肥胖有所论述,《内经》最早将肥胖分为脂、膏、肉3种,并指出此乃膏粱之疾也。《金匮要略》中指出多逸少劳者出现骨弱而肌肤盛之体态。现代对肥胖病因的认识承袭前人观点,认为主要包括先天禀赋不足、饮食不节、七情内伤、久卧久坐、外感湿邪、年老体衰。陈修园在《医学实在易》中指出肥胖者主要由于津液运化失常,痰湿内生所致,认为痰湿与肥胖的产生关系密切。现代也有学者认为痰湿是肥胖形成的基础,又可兼加胃热、气滞、血瘀等。在痰湿之外,也愈加重视对其他因素的研究。在超重和肥胖人群中,气虚质占据大多数,气虚不运而致痰湿内停,并认为睡眠习惯及长期居住环境是气虚体质形成的关键因素。中医学认为,肥胖可分为三种类型:气虚型肥胖,痰湿型肥胖以及血瘀型肥胖,其中气虚型肥胖多采用健脾益气的方法进行治疗,而痰湿型肥胖则以化痰祛湿为主,血瘀型肥胖大部分以活血祛瘀的方式进行调理。但上述方法均忽略了滋养肝肾而只一味地活血或祛湿,并未从肝肾入手进行全局的统筹调理,更不必说兼顾气血。
发明内容
为了解决上述问题,本发明提供一种配伍合理,能清热利湿、行气助阳、舒肝益气、且无明显肝肾毒性的中药组合物,能有效改善人体肝气郁滞、气机不畅的情况,适合应用到肝郁气滞型肥胖治疗中;本发明还提供了上述中药组合物的制备方法。
本发明采用的技术方案是:一种调节肝郁气滞型肥胖的中药组合物,所述中药组合物的各组份为合欢皮、决明子、牛蒡、连翘、枳壳、千金子、补骨脂、甘草;
进一步地,各种组份的重量份数为合欢皮25-30份、决明子25-30份、牛蒡15-20份、连翘15-20份、枳壳5-10份、千金子5-10份、补骨脂5-10份、甘草1-5份;
进一步地,各种组份的重量份数为合欢皮26-32份、决明子25-30份、牛蒡16-19份、连翘16-19份、枳壳7-10份、千金子6-8份、补骨脂5-7份、甘草2-4份;
进一步地,所述中药组合物的剂型选自:汤剂、片剂、颗粒剂或粉剂;
进一步地,所述中药组合物的剂型为汤剂。
本发明还提供了如上所述调节肝郁气滞型肥胖的中药组合物的制备方法,当所述中药组合物的剂型为汤剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至汤色醇郁,即为产品;
当所述中药组合物的剂型为颗粒剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至近干。加入赋形剂后造粒,即为产品。
当所述中药组合物的剂型为粉剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至近干后,阴凉处晾干,碾成粉末,即为产品。
本发明的中药组合物的药味解析如下:
合欢皮,味甘、性平,归心、肝经,安神解郁、活血消肿。
决明子,味甘、微苦,性微寒,归肝、大肠经,清肝明目、润肠通便。
牛蒡,味辛、微苦,性寒,清热解毒、疏风利咽。
连翘,味苦、性凉,清热,解毒,散结,消肿。治温热,丹毒,斑疹,痈疡肿毒,瘰疬,小便淋闭。
枳壳,味苦、辛、酸,性微寒,归脾、胃经,理气宽中,行滞消胀。
千金子,味辛,性温,有毒,归肝、肾、大肠经,逐水消肿,破血消癓。用于水肿,痰饮,积滞胀满,二便不通,血瘀经闭。
补骨脂,味辛、苦,性温,归肾、脾经,温肾助阳,纳气,止泻。用于阳痿遗精,遗尿尿频,腰膝冷痛,肾虚作喘,五更泄泻。
甘草,味甘、性平,归心、肺、脾、胃经,补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。
本发明的有益效果:
1)中医学认为,肥胖病的主要发病因素是肾气虚衰,脾失健运,湿浊内聚。肥胖的病理性质属于本虚标实,脾肾虚衰为主要的本虚表现,标实则以痰湿和瘀血为主。病位主要在脾与肌肉,但与肾、肺、肝、胆等脏关系密切。肝郁气滞型肥胖属于肝郁和气滞病机相挟,痰、瘀、湿等浊邪互为影响,瘀血的形成与痰浊阻滞、气机不畅密切相关,痰湿妨碍血行,使气机郁滞、血行不畅。故中医治疗肝郁气滞型肥胖多以活血化痰为主,而忽略了健脾调肝。本申请组方中合欢皮通常被认为能够解郁安神、化瘀消肿,以清肝明目、润肠通便的决明子相配共同作为君药可加强疏肝解郁之功效,配以清热解毒的牛蒡、散结消肿的连翘为臣药,可收利窍除湿、逐水生津之效;再以理气宽中的枳壳、逐水消癓的千金子、温肾助阳的补骨脂作为佐使药,可起到利水实脾、纳气护肾的作用,甘草调和诸药,共奏解郁化湿、平肝益气的协同功效,其中补骨脂的加入可起到助阳气的作用,能从根本上改善传统的疏肝祛湿的药味中对肾压力过大的问题,从而实现调五脏的作用,平肝温肾、有利于瘀滞的气血运行,牛蒡中亦含有抗肾炎的物质,对改善肝郁气滞型肥胖非常有效。
2)本发明的组方讲究君臣佐使相互配伍,组方合理,能有效提高药物之间的协同效应,能清热利湿、行气助阳、舒肝益气、且无明显肝肾毒性,可有效改善人体肝气郁滞、气机不畅的情况,适合应用到肝郁气滞型肥胖治疗中。
具体实施方式
实施例1:
一种调节肝郁气滞型肥胖的中药,由以下原料药按重量份配比而成:合欢皮30份、决明子26份、牛蒡18份、连翘16份、枳壳8份、千金子5份、补骨脂7份、甘草2份。
具体制备步骤:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量30倍的水浸泡2小时、小火煎3小时,将得到的药汤过滤后大火煎至汤色醇郁,即为产品。
实施例2:
一种调节肝郁气滞型肥胖的中药,由以下原料药按重量份配比而成:合欢皮30份、决明子26份、牛蒡18份、连翘16份、枳壳8份、千金子5份、补骨脂5份、甘草2份。
具体制备步骤:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡2小时、小火煎3小时,将得到的药汤过滤后大火煎至近干后,阴凉处晾干,碾成粉末,即为产品。
实施例3:
(一)选取肝郁气滞型肥胖患者120例,年龄20-70岁,均符合西医《单纯性肥胖病的诊断及疗效评定标准》和中医《中药新药临床研究指导原则试行》中关于肝郁脾虚型的诊断标准:症见形体肥胖,胸胁胀闷,情绪不定,性情抑郁或烦躁易怒,大便时干时稀或溏薄,排便不爽,女子***,易见痛经或闭经,带下量多而色淡黄,舌质淡红,苔白腻,脉弦或缓。
(二)疗效标准:
参照1987年全国首届肥胖病研究研究学术会议标准予以疗效评价。
痊愈:体质量下降至标准体质量或超重范围内;
显效:体质量下降I度或脂肪百分率下降5%以上或体质量下降5kg以上;
有效:体质量下降3kg以上,脂肪百分率下降5%;
无效:体质量无变化,脂肪百分率无变化。
(三)本发明治疗参与统计的患者20-70岁共120例,分为汤剂治疗组、粉剂治疗组、对照组每组40人:
汤剂治疗组:三餐后口服,一次300ml,一日三次,连服一个月;
粉剂治疗组:三餐后口服,一次20g、温水送服,一日三次,连服一个月;
对照组:口服奥利司他片,餐后服用1片(含奥利司他0.12g/片),一日三次,连服一个月。
组别 | 治愈 | 显效 | 有效 | 无效 | 总有效率 |
汤剂组 | 27 | 13 | 0 | 0 | 100% |
粉剂组 | 26 | 12 | 1 | 1 | 97.5% |
对照组 | 16 | 9 | 8 | 7 | 82.5% |
可见,使用本发明的中药组合物进行治疗的组的总有效率存在差异,说明调整了补骨脂的分量对药效有影响,在治疗期间未发现明显的肝肾毒性或其它毒副作用。
Claims (8)
1.一种调节肝郁气滞型肥胖的中药组合物,其特征在于,所述中药组合物的各组份为合欢皮、决明子、牛蒡、连翘、枳壳、千金子、补骨脂、甘草。
2.如权利要求1所述的中药组合物,其特征在于,各种组份的重量份数为合欢皮25-30份、决明子25-30份、牛蒡15-20份、连翘15-20份、枳壳5-10份、千金子5-10份、补骨脂5-10份、甘草1-5份。
3.如权利要求2所述的中药组合物,其特征在于,各种组份的重量份数为合欢皮26-32份、决明子25-30份、牛蒡16-19份、连翘16-19份、枳壳7-10份、千金子6-8份、补骨脂5-7份、甘草2-4份。
4.如权利要求1-3中任一项所述调节肝郁气滞型肥胖的中药组合物,其特征在于,所述中药组合物的剂型选自:汤剂、片剂、颗粒剂或粉剂。
5.如权利要求4所述调节肝郁气滞型肥胖的中药组合物,其特征在于,所述中药组合物的剂型为汤剂。
6.一种如权利要求1-5中任一项所述调节肝郁气滞型肥胖的中药组合物的制备方法,其特征在于:当所述中药组合物的剂型为汤剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至汤色醇郁,即为产品。
7.一种如权利要求1-5中任一项所述调节肝郁气滞型肥胖的中药组合物的制备方法,其特征在于:当所述中药组合物的剂型为颗粒剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至近干。加入赋形剂后造粒,即为产品。
8.一种如权利要求1-5中任一项所述调节肝郁气滞型肥胖的中药组合物的制备方法,其特征在于:当所述中药组合物的剂型为粉剂时,包括:
将诸药味碾碎后过筛并混合均匀,再加入相当于诸药味混合物质量10-50倍的水浸泡1-5小时、小火煎1-5小时,将得到的药汤过滤后大火煎至近干后,阴凉处晾干,碾成粉末,即为产品。
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