CN111296476A - Long-acting disinfectant containing potassium hydrogen persulfate and preparation method thereof - Google Patents
Long-acting disinfectant containing potassium hydrogen persulfate and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
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Abstract
The invention relates to the technical field of disinfection, and particularly relates to a long-acting disinfectant containing potassium hydrogen persulfate and a preparation method thereof. The preparation raw materials at least comprise the following components in parts by weight: 40-60 parts of oxidant, 5-15 parts of buffering agent, 10-25 parts of surfactant, 2-10 parts of synergist, 5-15 parts of activator and 0.05-1 part of indicator. The bactericide provided by the invention has the advantages of low toxicity, no irritation, long acting, stability and convenience in use. In addition, the bactericide provided by the invention is colored powder, the product is colored liquid after being dissolved, the color represents that the disinfectant also has a disinfection effect, and the disinfection effect can be further explained to be invalid after the color is changed into colorless.
Description
Technical Field
The invention relates to the technical field of disinfection, and particularly relates to a long-acting disinfectant containing potassium hydrogen persulfate and a preparation method thereof.
Background
The disinfectant is a bactericidal drug. Has strong killing effect on various pathogenic bacteria, viruses, fungi and the like. At present, the method is widely used for disinfection and sterilization of environment and instruments, disinfection and treatment of medical sewage and disinfection and sterilization of breeding places. The preparation can kill pathogenic microorganism on the transmission medium to make it reach the harmless requirement, is different from antibiotic, and its main action in preventing disease is to kill pathogenic microorganism outside human body or animal body, cut off the transmission path of various epidemic diseases and achieve the goal of controlling various epidemic diseases.
The disinfectant can be divided into a sterilizing agent, a high-efficiency disinfectant, a middle-efficiency disinfectant and a low-efficiency disinfectant according to the action level. The high-efficiency disinfectant can kill all bacteria propagules (including mycobacteria), viruses, fungi, spores thereof and the like, has a certain killing effect on bacterial spores, meets the requirement of high-level disinfection, and comprises chlorine-containing disinfectant, ozone, methyl hydantoin compounds, double-chain quaternary ammonium salt and the like. The intermediate disinfectant can only kill microbes such as mycobacteria, fungi, viruses, bacterial propagules and the like, meets the disinfection requirement and comprises iodine-containing disinfectant, alcohol disinfectant, phenol disinfectant and the like. The low-efficiency disinfectant can only kill bacteria propagules and lipophilic viruses to meet the requirements of the disinfectant, and comprises quaternary ammonium salt disinfectants such as benzalkonium bromide and the like, biguanide disinfectants such as chlorhexidine (chlorhexidine) and the like, metal ion disinfectants such as mercury, silver, copper and the like and Chinese herbal medicine disinfectants.
The disinfectants all have respective defects, such as poor stability, high corrosivity, strong irritation, narrow antibacterial spectrum and the like, and some disinfectants even have carcinogenic risks, so the disinfectants have certain limitations in clinical application. Therefore, the development of a disinfectant with broad spectrum, high efficiency, low toxicity, no irritation, long-acting effect, stability and convenient use is a development trend.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a long-acting disinfectant containing potassium hydrogen persulfate, which comprises the following raw materials in parts by weight: 40-60 parts of oxidant, 5-15 parts of buffering agent, 10-25 parts of surfactant, 2-10 parts of synergist, 5-15 parts of activator and 0.05-1 part of indicator.
As a preferable technical scheme, the oxidizing agent is a potassium monopersulfate composite salt compounded with sodium dichloroisocyanurate.
In a preferred embodiment of the present invention, the buffer is selected from one or more of tartaric acid, malic acid, benzoic acid, salicylic acid, phthalic acid, sodium phosphate, and potassium phosphate.
In a preferred embodiment of the present invention, the surfactant is selected from anionic surfactants and/or nonionic surfactants.
As a preferable technical scheme of the invention, the surfactant is selected from one or more of isomeric dodecyl alcohol polyoxyethylene ether, isomeric tridecanol polyoxyethylene ether, isooctyl alcohol polyoxyethylene ether, lauric acid polyoxyethylene ester, sodium dodecyl sulfate and sodium dodecyl benzene sulfonate.
As a preferable technical solution of the present invention, the surfactant is a combination of polyoxyethylene laurate and sodium dodecylbenzenesulfonate, wherein the mass ratio of the polyoxyethylene laurate to the sodium dodecylbenzenesulfonate is 0.5: (1-4).
As a preferable technical scheme of the invention, the synergist is sodium chloride and/or potassium chloride.
In a preferred embodiment of the present invention, the activating agent is one or more selected from sulfamic acid, sodium sulfamate and potassium sulfamate.
As a preferred technical scheme of the invention, the indicator is selected from one or more of carmine, erythrosine, new red, beet red, roselle red, lac red orange, grape skin red, monascus red, mallow red, black currant red, mulberry red and capsanthin.
As a preferable technical scheme of the invention, the preparation method comprises the following steps: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
Has the advantages that: the invention provides a long-acting disinfectant containing potassium hydrogen persulfate and a preparation method thereof, and a long-acting bactericide with excellent bactericidal effect is obtained by specially selecting an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator and reasonably and effectively controlling the proportion of the components; compared with the existing disinfectant, the disinfectant has stronger bactericidal capacity, and in addition, the long-acting disinfectant containing the potassium hydrogen persulfate provided by the invention has excellent stability, can continuously sterilize and effectively improve the duration of sterilization; by adding the indicator, the bactericide provided by the invention is colored powder, the product is colored liquid after being dissolved, the color represents that the disinfectant also has a disinfection effect, and the disinfection effect can be further explained to be invalid after the color is changed into colorless, so that convenience is provided for a user to judge the action time of the disinfectant. Finally, the preparation method is simple, safe and convenient to operate, and has considerable development prospect.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.
Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.
In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.
In order to solve the technical problems, the first aspect of the invention provides a long-acting disinfectant containing potassium hydrogen persulfate, which comprises the following raw materials in parts by weight: 40-60 parts of oxidant, 5-15 parts of buffering agent, 10-25 parts of surfactant, 2-10 parts of synergist, 5-15 parts of activator and 0.05-1 part of indicator.
In a preferred embodiment, the long-acting disinfectant containing potassium hydrogen persulfate is prepared by at least the following raw materials in parts by weight: 45-55 parts of oxidant, 8-12 parts of buffer, 12-20 parts of surfactant, 4-8 parts of synergist, 8-12 parts of activator and 0.4-0.8 part of indicator.
In a most preferred embodiment, the long-acting disinfectant containing potassium hydrogen persulfate is prepared by at least the following raw materials in parts by weight: 50 parts of oxidizing agent, 10 parts of buffering agent, 15 parts of surfactant, 5 parts of synergist, 10 parts of activator and 0.6 part of indicator.
Oxidizing agent
The oxidant of the present invention has the property of getting electrons, called oxidizing property, and the determinants of the oxidizing property are the electron getting tendency of high valence elements in the material. In solution, according to the theory of electric double layers, the magnitude of the oxidation is reflected as the standard hydrogen electrode potential of the oxidant: the higher the potential, the stronger the oxidation; the lower the potential, the weaker the oxidizing property and correspondingly the stronger the reducing property of the reduced state.
In a preferred embodiment, the oxidizing agent of the present invention is a combination of potassium monopersulfate complex salt and sodium dichloroisocyanurate.
In a preferred embodiment, the oxidant is a combination of potassium monopersulfate complex salt and sodium dichloroisocyanurate, wherein the mass ratio of the potassium monopersulfate complex salt to the sodium dichloroisocyanurate is (8-10): 1.
in a most preferred embodiment, the oxidant of the present invention is a combination of potassium monopersulfate complex salt and sodium dichloroisocyanurate, wherein the mass ratio of the potassium monopersulfate complex salt to the sodium dichloroisocyanurate is 9: 1.
the molecular formula of the potassium monopersulfate composite salt is 2KHSO5·KHSO4·K2SO4The potassium monopersulfate composite salt is a white powdery substance at normal temperature, is easy to store and transport, and has the advantages of high stability, high water solubility and relatively low price; the disinfectant is non-combustible and non-explosive, and potential safety hazards such as leakage, overturning, explosion, corrosion and the like of other disinfectants are overcome in multiple links such as production, transportation, storage and use; can be stored for two years at normal temperature.
The inventor finds in experiments that the sterilization capability and the sterilization persistence of the disinfectant are effectively increased by the compounding of the potassium monopersulfate complex salt and the sodium dichloroisocyanurate, which is probably because the sodium dichloroisocyanurate acts on the surface of a sterilized object to slowly release hypochlorous acid, and has a synergistic effect with the potassium monopersulfate complex salt, so that not only can various bacteria, algae, fungi and germs be killed, but also the oxidation capability of the potassium monopersulfate complex salt can be effectively improved, the chain reaction of the potassium monopersulfate complex salt in water is promoted, hydrogen peroxide, hypochlorous acid, free hydroxyl and nascent oxygen are continuously generated, the potassium monopersulfate complex salt further acts on microorganisms to inhibit the generation of enzymes in the microorganisms, the synthesis of protein is prevented, the sterilization effect is realized, and simultaneously, chloride released after the microorganisms are killed is oxidized into hypochlorous acid and free hydroxyl by active oxygen of the potassium monopersulfate, can be used for long-term action. Especially when the mass ratio of the potassium monopersulfate composite salt to the sodium dichloroisocyanurate is (8-10): 1, the effect is best, and when the content of sodium dichloroisocyanurate is less, the sterilization capability is reduced; when the content of sodium dichloroisocyanurate is high, the chain reaction of the potassium monopersulfate composite salt in the water body is hindered, so that the continuity of sterilization is influenced.
Buffering agent
The buffer of the invention is a solid composition which can be used for controlling the fugacity of gas or liquid under the conditions of high temperature and high pressure or normal temperature and normal pressure, and can be solid or liquid. The acid or base in the salt is gradually released during the reaction or preservation to maintain a stable pH value.
In a preferred embodiment, the buffer according to the invention is selected from one or more of tartaric acid, malic acid, benzoic acid, salicylic acid, phthalic acid, sodium phosphate, potassium phosphate.
In a more preferred embodiment, the buffer of the present invention is malic acid.
Surface active agent
The surfactant is a substance which is added in a small amount and can cause the interface state of a solution system of the surfactant to change obviously. Has fixed hydrophilic and lipophilic groups and can be directionally arranged on the surface of the solution. The molecular structure of the surfactant has amphipathy: one end is a hydrophilic group, and the other end is a hydrophobic group; the hydrophilic group is often a polar group, such as carboxylic acid, sulfonic acid, sulfuric acid, amino or amino groups and salts thereof, hydroxyl, amide, ether linkages, and the like may also be used as the polar hydrophilic group; and the hydrophobic group is often a non-polar hydrocarbon chain, such as a hydrocarbon chain of 8 or more carbon atoms.
In a preferred embodiment, the surfactant according to the invention is selected from anionic surfactants and/or nonionic surfactants.
In a more preferred embodiment, the surfactant of the present invention is selected from one or more of isomeric polyoxyethylene tridecanol ether, isooctanol polyoxyethylene ether, polyoxyethylene laurate, sodium lauryl sulfate, and sodium dodecylbenzenesulfonate.
In a more preferred embodiment, the surfactant of the present invention is a combination of polyoxyethylene laurate and sodium dodecylbenzenesulfonate, wherein the mass ratio of the polyoxyethylene laurate to the sodium dodecylbenzenesulfonate is 0.5: (1-4).
In a most preferred embodiment, the surfactant of the present invention is a combination of polyoxyethylene laurate and sodium dodecylbenzene sulfonate, wherein the mass ratio of the polyoxyethylene laurate to the sodium dodecylbenzene sulfonate is 0.5: 3.
the lauric acid polyoxyethylene ester can be obtained commercially, and the manufacturer includes but is not limited to Hainan cloud chemical Co., Ltd, and the trade name is LAE-24.
The inventor finds in experiments that the combination of lauric acid polyoxyethylene ester and sodium dodecyl benzene sulfonate is adopted as the surfactant, so that the application range of the disinfectant is favorably expanded, the disinfectant can be widely applied to sewage sterilization, industrial sterilization, kitchen oil fume sterilization and the like, and the stability of the disinfectant is improved, and the possible reason is that the disinfectant is beneficial to forming a rich network structure by the surfactant by selecting the surfactant containing a long carbon chain structure and an active group, the potassium monopersulfate composite salt is coated to a certain degree, the stability of the potassium monopersulfate composite salt is improved, the duration of the disinfectant is further prolonged, and particularly the mass ratio of the lauric acid polyoxyethylene ester to the sodium dodecyl benzene sulfonate is 0.5: (1-4), the effect is best.
Synergist
The synergist of the invention generally refers to a substance which does not have a certain specific activity or has low activity, but can greatly improve the performance of an active substance when being mixed with the substance with the activity.
In a preferred embodiment, the synergist of the invention is sodium chloride and/or potassium chloride.
In a most preferred embodiment, the potentiator of the present invention is sodium chloride.
Activating agent
The activating agent of the invention refers to an agent capable of increasing the activation of other substances.
In a preferred embodiment, the activator according to the invention is selected from one or more of sulfamic acid, sodium sulfamate and potassium sulfamate.
In a most preferred embodiment, the activator of the present invention is sulfamic acid.
Indicator agent
The indicator of the invention is that the color of the indicator can change under certain medium conditions to indicate the existence of effective components in the medicament.
In a preferred embodiment, the indicator is selected from one or more of carmine, erythrosine, neo-red, beet red, roselle red, shellac red, grape skin red, monascus red, red balm red, black currant red, mulberry red, capsanthin.
In a most preferred embodiment, the indicator of the present invention is beet red.
In a second aspect, the invention provides a preparation method of a long-acting disinfectant containing potassium hydrogen persulfate, which comprises the following steps: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the raw materials used are commercially available from national chemical reagents, unless otherwise specified.
Examples
In order to better understand the above technical solutions, the following detailed descriptions will be provided with reference to specific embodiments. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention. In addition, the raw materials are commercially available and the extraction methods of the extract are all conventional extraction methods, if not otherwise specified.
Example 1
The long-acting disinfectant containing potassium hydrogen persulfate is provided, and the preparation raw materials comprise the following components in parts by weight: 50 parts of oxidizing agent, 10 parts of buffering agent, 15 parts of surfactant, 5 parts of synergist, 10 parts of activator and 0.6 part of indicator.
The oxidant is a compound of potassium monopersulfate composite salt and sodium dichloroisocyanurate, wherein the mass ratio of the potassium monopersulfate composite salt to the sodium dichloroisocyanurate is 9: 1.
the buffer is malic acid.
The surfactant is a combination of lauric acid polyoxyethylene ester and sodium dodecyl benzene sulfonate, wherein the mass ratio of the lauric acid polyoxyethylene ester to the sodium dodecyl benzene sulfonate is 0.5: 3.
the lauric acid polyoxyethylene ester can be obtained commercially, and is manufactured by Hainan cloud chemical Co., Ltd under the trade name LAE-24.
The synergist is sodium chloride.
The activator is sulfamic acid.
The indicator is beet red.
The preparation method of the long-acting disinfectant containing potassium hydrogen persulfate comprises the following steps: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
Example 2
The long-acting disinfectant containing potassium hydrogen persulfate is provided, and the preparation raw materials comprise the following components in parts by weight: 40 parts of oxidizing agent, 5 parts of buffering agent, 10 parts of surfactant, 2 parts of synergist, 5 parts of activator and 0.05 part of indicator.
The oxidant is a compound of potassium monopersulfate composite salt and sodium dichloroisocyanurate, wherein the mass ratio of the potassium monopersulfate composite salt to the sodium dichloroisocyanurate is 9: 1.
the buffer is malic acid.
The surfactant is a combination of lauric acid polyoxyethylene ester and sodium dodecyl benzene sulfonate, wherein the mass ratio of the lauric acid polyoxyethylene ester to the sodium dodecyl benzene sulfonate is 0.5: 3.
the lauric acid polyoxyethylene ester can be obtained commercially, and is manufactured by Hainan cloud chemical Co., Ltd under the trade name LAE-24.
The synergist is sodium chloride.
The activator is sulfamic acid.
The indicator is beet red.
The preparation method of the long-acting disinfectant containing potassium hydrogen persulfate comprises the following steps: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
Example 3
The long-acting disinfectant containing potassium hydrogen persulfate is provided, and the preparation raw materials comprise the following components in parts by weight: 60 parts of oxidizing agent, 15 parts of buffering agent, 25 parts of surfactant, 10 parts of synergist, 15 parts of activator and 1 part of indicator.
The oxidant is a compound of potassium monopersulfate composite salt and sodium dichloroisocyanurate, wherein the mass ratio of the potassium monopersulfate composite salt to the sodium dichloroisocyanurate is 9: 1.
the buffer is malic acid.
The surfactant is a combination of lauric acid polyoxyethylene ester and sodium dodecyl benzene sulfonate, wherein the mass ratio of the lauric acid polyoxyethylene ester to the sodium dodecyl benzene sulfonate is 0.5: 3.
the lauric acid polyoxyethylene ester can be obtained commercially, and is manufactured by Hainan cloud chemical Co., Ltd under the trade name LAE-24.
The synergist is sodium chloride.
The activator is sulfamic acid.
The indicator is beet red.
The preparation method of the long-acting disinfectant containing potassium hydrogen persulfate comprises the following steps: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
Example 4
Similar to example 1, except that sodium dichloroisocyanurate is absent from the oxidizing agent.
Example 5
Similar to example 1, except that the mass ratio of the oxone complex salt to sodium dichloroisocyanurate was 5: 1.
example 6
Similar to example 1, except that the mass ratio of the oxone complex salt to sodium dichloroisocyanurate was 12: 1.
example 7
Similar to example 1, except that no lauric acid polyoxyethylene ester was present in the surfactant.
Example 8
Similar to example 1, except that the surfactant was free of sodium dodecylbenzenesulfonate.
Evaluation of Performance
1. And (3) stability testing: the long-acting disinfectant containing potassium hydrogen persulfate provided in examples 1, 7 and 8 was left at 50 ℃. + -. 2 ℃ and 75%. + -. 5% relative humidity for 6 months, samples were taken at the end of months 1, 2, 3 and 6, respectively, and the effective chlorine content was measured, and 3 parallel tests were performed on each sample, and the results are shown in table 1.
TABLE 1 stability results
2. Microbiological kill test
The inspection basis is as follows: the department of health, 2002 edition "Disinfection technical Specification".
Experimental strains: escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231), and Bacillus subtilis var niger (ATCC 9372).
Test temperature: at 20 ℃.
Concentration of the disinfectant: 5% aqueous solution.
And (3) sterilization time: escherichia coli (8099), Staphylococcus aureus (ATCC6538), Candida albicans (ATCC10231) for 5 min; bacillus subtilis var niger (ATCC9372) for 15 min.
Under experimental conditions, the long-acting disinfectant containing oxone provided in examples 1-6 can completely kill escherichia coli (8099), staphylococcus aureus (ATCC6538), candida albicans (ATCC10231) and bacillus subtilis var niger (ATCC9372) for 5min, 5min and 15min respectively, and the experimental results are shown in table 1.
TABLE 1 log kill
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (10)
1. The long-acting disinfectant containing potassium hydrogen persulfate is characterized by comprising the following raw materials in parts by weight: 40-60 parts of oxidant, 5-15 parts of buffering agent, 10-25 parts of surfactant, 2-10 parts of synergist, 5-15 parts of activator and 0.05-1 part of indicator.
2. The extended disinfectant containing oxone according to claim 1, wherein the oxidizing agent is a combination of oxone complex salt and sodium dichloroisocyanurate.
3. The extended disinfectant containing oxone as claimed in claim 1, wherein the buffering agent is selected from one or more of tartaric acid, malic acid, benzoic acid, salicylic acid, phthalic acid, sodium phosphate, potassium phosphate.
4. The extended disinfectant containing oxone according to claim 1, wherein the surfactant is selected from anionic surfactants and/or nonionic surfactants.
5. The extended disinfectant containing oxone according to claim 1, wherein the surfactant is selected from one or more of isomeric tridecanol polyoxyethylene ether, isooctanol polyoxyethylene ether, lauric acid polyoxyethylene ester, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate.
6. The long-acting disinfectant containing potassium hydrogen persulfate according to claim 5, wherein the surfactant is a combination of polyoxyethylene laurate and sodium dodecylbenzene sulfonate, wherein the mass ratio of the polyoxyethylene laurate to the sodium dodecylbenzene sulfonate is 0.5: (1-4).
7. The extended disinfectant containing oxone according to claim 1, wherein the synergist is sodium chloride and/or potassium chloride.
8. The extended disinfectant containing oxone according to claim 1, wherein the activator is selected from one or more of sulfamic acid, sodium sulfamate, potassium sulfamate.
9. The extended disinfectant containing oxone according to claim 1, wherein the indicator is selected from one or more of carmine, erythrosine, neo-red, beet red, roselle red, shellac red, grape skin red, monascus red, mallow red, black currant red, morula red, capsanthin.
10. A method of preparing a extended disinfectant containing oxone as claimed in any one of claims 1-9, comprising the steps of: respectively drying, grinding and sieving an oxidant, a buffering agent, a surfactant, a synergist, an activator and an indicator, and uniformly mixing to obtain the composite material.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111903674A (en) * | 2020-08-05 | 2020-11-10 | 马保臣 | Potassium hydrogen persulfate composite powder with uniform and stable quality and preparation process thereof |
| CN112450209A (en) * | 2020-12-09 | 2021-03-09 | 淄博鑫欧瑞环保科技有限公司 | Disinfectant powder synergist |
| CN113712028A (en) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | Photoluminescent long-acting film-forming disinfection composition and preparation method and application thereof |
| CN113854290A (en) * | 2021-10-11 | 2021-12-31 | 中科朗劢技术有限公司 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
| CN114106936A (en) * | 2021-12-10 | 2022-03-01 | 广东腾骏药业股份有限公司 | Foaming type cleaning agent with disinfection function for farm |
| CN114403155A (en) * | 2022-01-17 | 2022-04-29 | 山东华辰制药有限公司 | Chlorine-free disinfection granular preparation and preparation method thereof |
| CN115088730A (en) * | 2021-10-19 | 2022-09-23 | 湖南坤源生物科技有限公司 | Sterilizing disinfectant and preparation method thereof |
| CN115152777A (en) * | 2022-08-01 | 2022-10-11 | 山东利尔康医疗科技股份有限公司 | Chlorine-containing disinfection powder for disinfection and sterilization of endoscope and preparation method thereof |
-
2020
- 2020-04-07 CN CN202010263380.3A patent/CN111296476A/en not_active Withdrawn
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111903674A (en) * | 2020-08-05 | 2020-11-10 | 马保臣 | Potassium hydrogen persulfate composite powder with uniform and stable quality and preparation process thereof |
| CN111903674B (en) * | 2020-08-05 | 2022-07-12 | 马保臣 | Potassium hydrogen persulfate composite powder with uniform and stable quality and preparation process thereof |
| CN113712028A (en) * | 2020-10-21 | 2021-11-30 | 南京百思福医药科技有限公司 | Photoluminescent long-acting film-forming disinfection composition and preparation method and application thereof |
| CN112450209A (en) * | 2020-12-09 | 2021-03-09 | 淄博鑫欧瑞环保科技有限公司 | Disinfectant powder synergist |
| CN113854290A (en) * | 2021-10-11 | 2021-12-31 | 中科朗劢技术有限公司 | Long-acting lasting biguanide compound disinfectant and preparation method thereof |
| CN115088730A (en) * | 2021-10-19 | 2022-09-23 | 湖南坤源生物科技有限公司 | Sterilizing disinfectant and preparation method thereof |
| CN114106936A (en) * | 2021-12-10 | 2022-03-01 | 广东腾骏药业股份有限公司 | Foaming type cleaning agent with disinfection function for farm |
| CN114403155A (en) * | 2022-01-17 | 2022-04-29 | 山东华辰制药有限公司 | Chlorine-free disinfection granular preparation and preparation method thereof |
| CN115152777A (en) * | 2022-08-01 | 2022-10-11 | 山东利尔康医疗科技股份有限公司 | Chlorine-containing disinfection powder for disinfection and sterilization of endoscope and preparation method thereof |
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Application publication date: 20200619 |